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School of Pharmacy : Arien-Zakay Hadar


 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Chiu W-, Kovacheva L, Musgrove RE, Arien-Zakay H, Koprich JB, Brotchie JM, et al. α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms. Sci Adv 2021;7(11).

(2) Lahiani A, Zahavi E, Netzer N, Ofir R, Pinzur L, Raveh S, et al. Human PLacental eXpanded (PLX) mesenchymal-like adherent stromal cells confer neuroprotection to nerve growth factor (NGF)-differentiated PC12 cells exposed to ischemia by secretion of IL-6 and VEGF. Biochim Biophys Acta Mol Cell Res 2015;1853(2):422-430.

(3) Arien-Zakay H, Gincberg G, Nagler A, Cohen G, Liraz-Zaltsman S, Trembovler V, et al. Neurotherapeutic effect of cord blood derived CD45+ hematopoietic cells in mice after traumatic brain injury. J Neurotrauma 2014;31(16):1405-1416.

(4) Bercu MM, Arien-Zakay H, Stoler D, Lecht S, Lelkes PI, Samuel S, et al. Enhanced survival and neurite network formation of human umbilical cord blood neuronal progenitors in three-dimensional collagen constructs. J Mol Neurosci 2013;51(2):249-261.

(5) Gincberg G, Arien-Zakay H, Lazarovici P, Lelkes PI. Neural stem cells: Therapeutic potential for neurodegenerative diseases. Br Med Bull 2012;104(1):7-19.

(6) Ettinger K, Lecht S, Arien-Zakay H, Cohen G, Aga-Mizrachi S, Yanay N, et al. Nerve growth factor stimulation of ERK1/2 phosphorylation requires both p75NTR and α9β1 integrin and confers myoprotection towards ischemia in C2C12 skeletal muscle cell model. Cell Signal 2012;24(12):2378-2388.

(7) Cohen G, Lecht S, Arien-Zakay H, Ettinger K, Amsalem O, Oron-Herman M, et al. Bio-Imaging of Colorectal Cancer Models Using Near Infrared Labeled Epidermal Growth Factor. PLoS ONE 2012;7(11).

(8) Lazarovici P, Cohen G, Arien-Zakay H, Chen J, Zhang C, Chopp M, et al. Multimodal neuroprotection induced by PACAP38 in Oxygen-glucose deprivation and middle cerebral artery occlusion stroke models. J Mol Neurosci 2012;48(3):526-540.

(9) Lecht S, Rotfeld E, Arien-Zakay H, Tabakman R, Matzner H, Yaka R, et al. Neuroprotective effects of nimodipine and nifedipine in the NGF-differentiated PC12 cells exposed to oxygen-glucose deprivation or trophic withdrawal. Int J Dev Neurosci 2012;30(6):465-469.

(10) Momic T, Arlinghaus FT, Arien-Zakay H, Katzhendler J, Eble JA, Marcinkiewicz C, et al. Pharmacological aspects of Vipera xantina palestinae venom. Toxins 2011;3(11):1420-1432.

(11) Arien-Zakay H, Lecht S, Nagler A, Lazarovici P. Neuroprotection by human umbilical cord blood-derived progenitors in ischemic brain injuries. Arch Ital Biol 2011;149(2):233-245.

(12) Arien-Zakay H, Lecht S, Nagler A, Lazarovici P. Human umbilical cord blood stem cells: Rational for use as a neuroprotectant in ischemic brain disease. Int J Mol Sci 2010;11(9):3513-3528.

(13) Lecht S, Arien-Zakay H, Wagenstein Y, Inoue S, Marcinkiewicz C, Lelkes PI, et al. Transient signaling of Erk1/2, Akt and PLCγ induced by nerve growth factor in brain capillary endothelial cells. Vasc Pharmacol 2010;53(3-4):107-114.

(14) Arien-Zakay H, Lazarovici P, Nagler A. Tissue regeneration potential in human umbilical cord blood. Best Pract Res Clin Haematol 2010;23(2):291-303.

(15) Lecht S, Arien-Zakay H, Kohan M, Lelkes PI, Lazarovici P. Angiostatic effects of K252a, a Trk inhibitor, in murine brain capillary endothelial cells. Mol Cell Biochem 2010;339(1-2):201-213.

(16) Lecht S, Arien-Zakay H, Marcinkiewicz C, Lelkes PI, Lazarovici P. Nerve growth factor-induced protection of brain capillary endothelial cells exposed to oxygen-glucose deprivation involves attenuation of erk phosphorylation. J Mol Neurosci 2010;41(1):183-192.

(17) Lecht S, Foerster C, Arien-Zakay H, Marcinkiewicz C, Lazarovici P, Lelkes PI. Cardiac microvascular endothelial cells express and release nerve growth factor but not fibroblast growth factor-2. In Vitro Cell Dev Biol Anim 2010;46(5):469-476.

(18) Arien-Zakay H, Lecht S, Perets A, Roszell B, Lelkes PI, Lazarovici P. Quantitative assessment of neuronal differentiation in three-dimensional collagen gels using enhanced green fluorescence protein expressing PC12 pheochromocytoma cells. J Mol Neurosci 2009;37(3):225-237.

(19) Arien-Zakay H, Lecht S, Bercu MM, Tabakman R, Kohen R, Galski H, et al. Neuroprotection by cord blood neural progenitors involves antioxidants, neurotrophic and angiogenic factors. Exp Neurol 2009;216(1):83-94.

(20) Arien-Zakay H, Lecht S, Bercu MM, Amariglio N, Rechavi G, Galski H, et al. Interferon-γ-induced neuronal differentiation of human umbilical cord blood-derived progenitors. Leukemia 2009;23(10):1790-1800.

(21) Arien-Zakay H, Nagler A, Galski H, Lazarovici P. Neuronal conditioning medium and nerve growth factor induce neuronal differentiation of collagen-adherent progenitors derived from human umbilical cord blood. J Mol Neurosci 2007;32(3):179-191.

(22) Tabakman R, Jiang H, Shahar I, Arien-Zakay H, Levine RA, Lazarovici P. Neuroprotection by NGF in the PC12 in vitro OGD model: Involvement of mitogen-activated protein kinases and gene expression. Ann New York Acad Sci 2005;1053:84-96.

(23) Tabakman R, Lecht S, Sephanova S, Arien-Zakay H, Lazarovici P. Interactions between the cells of the immune and nervous system: Neurotrophins as neuroprotection mediators in CNS injury. Prog Brain Res 2004;146:385-401.

(24) Arien H, Wiser O, Arkin IT, Leonov H, Atlas D. Syntaxin 1A modulates the voltage-gated L-type calcium channel (Cavl.2) in a cooperative manner. J Biol Chem 2003;278(31):29231-29239.