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School of Pharmacy : Benita Simon


 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Rebibo L, Tam C, Sun Y, Shoshani E, Badihi A, Nassar T, et al. Topical tacrolimus nanocapsules eye drops for therapeutic effect enhancement in both anterior and posterior ocular inflammation models. J Control Release 2021;333:283-297.

(2) Abd-Elrahman I, Nassar T, Khairi N, Perlman R, Benita S, Ben Yehuda D. Novel targeted mtLivin nanoparticles treatment for disseminated diffuse large B-cell lymphoma. Oncogene 2021;40(2):334-344.

(3) Badihi A, Frušić-Zlotkin M, Soroka Y, Benhamron S, Tzur T, Nassar T, et al. Topical nano-encapsulated cyclosporine formulation for atopic dermatitis treatment: Topical cyclosporine NCs for AD. Nanomed Nanotechnol Biol Med 2020;24.

(4) Nassar T, Rohald A, Naraykin N, Barasch D, Amsalem O, Prabhu P, et al. Nanocapsules embedded in microparticles for enhanced oral bioavailability and efficacy of Lopinavir as an anti-AIDS drug. J Drug Targeting 2019;27(5-6):590-600.

(5) Soudry-Kochavi L, Naraykin N, Di Paola R, Gugliandolo E, Peritore A, Cuzzocrea S, et al. Pharmacodynamical effects of orally administered exenatide nanoparticles embedded in gastro-resistant microparticles. Eur J Pharm Biopharm 2018;133:214-223.

(6) Lallemand F, Schmitt M, Bourges J-, Gurny R, Benita S, Garrigue J-. Cyclosporine A delivery to the eye: A comprehensive review of academic and industrial efforts. Eur J Pharm Biopharm 2017;117:14-28.

(7) Amsalem O, Nassar T, Benhamron S, Lazarovici P, Benita S, Yavin E. Solid nano-in-nanoparticles for potential delivery of siRNA. J Control Release 2017;257:144-155.

(8) Debotton N, Badihi A, Robinpour M, Enk CD, Benita S. Dermal absorption behavior of fluorescent molecules in nanoparticles on human and porcine skin models. Int J Pharm 2017;524(1-2):290-303.

(9) Abu Ammar A, Raveendran R, Gibson D, Nassar T, Benita S. A Lipophilic Pt(IV) Oxaliplatin Derivative Enhances Antitumor Activity. J Med Chem 2016;59(19):9035-9046.

(10) Hamdi Y, Lallemand F, Benita S. Drug-loaded nanocarriers for back-of-the-eye diseases- formulation limitations. J Drug Deliv Sci Technol 2015;30:331-341.

(11) Soudry-Kochavi L, Naraykin N, Nassar T, Benita S. Improved oral absorption of exenatide using an original nanoencapsulation and microencapsulation approach. J Control Release 2015;217:202-210.

(12) Badihi A, Debotton N, Frušić-Zlotkin M, Soroka Y, Neuman R, Benita S. Enhanced cutaneous bioavailability of dehydroepiandrosterone mediated by nano-encapsulation. J Control Release 2014;189:65-71.

(13) Karra N, Nassar T, Ripin AN, Schwob O, Borlak J, Benita S. Antibody conjugated PLGA nanoparticles for targeted delivery of paclitaxel palmitate: Efficacy and biofate in a lung cancer mouse model. Small 2013;9(24):4221-4236.

(14) Attili-Qadri S, Karra N, Nemirovski A, Schwob O, Talmon Y, Nassar T, et al. Oral delivery system prolongs blood circulation of docetaxel nanocapsules via lymphatic absorption. Proc Natl Acad Sci U S A 2013;110(43):17498-17503.

(15) Karra N, Nassar T, Laenger F, Benita S, Borlak J. Safety and proof-of-concept efficacy of inhaled drug loaded nano- and immunonanoparticles in a c-Raf transgenic lung cancer model. Curr Cancer Drug Targets 2013;13(1):11-29.

(16) Cohen G, Lecht S, Arien-Zakay H, Ettinger K, Amsalem O, Oron-Herman M, et al. Bio-Imaging of Colorectal Cancer Models Using Near Infrared Labeled Epidermal Growth Factor. PLoS ONE 2012;7(11).

(17) Hagigit T, Abdulrazik M, Valamanesh F, Behar-Cohen F, Benita S. Ocular antisense oligonucleotide delivery by cationic nanoemulsion for improved treatment of ocular neovascularization: An in-vivo study in rats and mice. J Control Release 2012;160(2):225-231.

(18) Pathak Y, Benita S. Antibody-Mediated Drug Delivery Systems: Concepts, Technology, and Applications. Antibody-Mediated Drug Delivery Systems: Concepts, Technology, and Applications; 2012.

(19) Pathak Y, Benita S. Preface. Antibody-Mediated Drug Delivery Syst : Concepts, Technol , and Appl 2012:xix-xxii.

(20) Giladi O, Benita S. Immunonanoparticles for Nuclear Imaging and Radiotherapy. Antibody-Mediated Drug Delivery Systems: Concepts, Technology, and Applications; 2012. p. 427-456.

(21) Karra N, Benita S. The ligand nanoparticle conjugation approach for targeted cancer therapy. Curr Drug Metab 2012;13(1):22-41.

(22) Hagigit T, Abdulrazik M, Orucov F, Valamanesh F, Lambert M, Lambert G, et al. Erratum: Topical and intravitreous administration of cationic nanoemulsions to deliver antisense oligonucleotides directed towards VEGF KDR receptors to the eye (Journal of Controlled Release (2010) 145: 3 (297-305)). J Control Release 2011;152(2):325.

(23) Nassar T, Attili-Qadri S, Harush-Frenkel O, Farber S, Lecht S, Lazarovici P, et al. High plasma levels and effective lymphatic uptake of docetaxel in an orally available nanotransporter formulation. Cancer Res 2011;71(8):3018-3028.

(24) Rozentur E, Nassar T, Benita S. Materials for nanoemulsions and their influence on the biofate. Handbook of Materials for Nanomedicine; 2010. p. 515-554.

(25) Hagigit T, Abdulrazik M, Orucov F, Valamanesh F, Lambert M, Lambert G, et al. Topical and intravitreous administration of cationic nanoemulsions to deliver antisense oligonucleotides directed towards VEGF KDR receptors to the eye. J Control Release 2010;145(3):297-305.

(26) Harush-Frenkel O, Bivas-Benita M, Nassar T, Springer C, Sherman Y, Avital A, et al. A safety and tolerability study of differently-charged nanoparticles for local pulmonary drug delivery. Toxicol Appl Pharmacol 2010;246(1-2):83-90.

(27) Debotton N, Zer H, Parnes M, Harush-Frenkel O, Kadouche J, Benita S. A quantitative evaluation of the molecular binding affinity between a monoclonal antibody conjugated to a nanoparticle and an antigen by surface plasmon resonance. Eur J Pharm Biopharm 2010;74(2):148-156.

(28) Nassar T, Rom A, Nyska A, Benita S. Novel double coated nanocapsules for intestinal delivery and enhanced oral bioavailability of tacrolimus, a P-gp substrate drug. J Control Release 2009;133(1):77-84.

(29) Goldstein D, Benita S. Paclitaxel palmitate-loaded anti-HER2 cationic immunoemulsion: Pharmacokinetic and biodistribution study in healthy mice. J Drug Deliv Sci Technol 2009;19(4):269-274.

(30) Debotton N, Giladi O, Parnes M, Benita S. Novel high-content paclitaxel palmitate nanospheres for improved cancer treatment. J Drug Deliv Sci Technol 2009;19(4):275-282.

(31) Nassar T, Rom A, Nyska A, Benita S. A novel nanocapsule delivery system to overcome intestinal degradation and drug transport limited absorption of P-glycoprotein substrate drugs. Pharm Res 2008;25(9):2019-2029.

(32) Hagigit T, Nassar T, Behar-Cohen F, Lambert G, Benita S. The influence of cationic lipid type on in-vitro release kinetic profiles of antisense oligonucleotide from cationic nanoemulsions. Eur J Pharm Biopharm 2008;70(1):248-259.

(33) Debotton N, Parnes M, Kadouche J, Benita S. Overcoming the formulation obstacles towards targeted chemotherapy: In vitro and in vivo evaluation of cytotoxic drug loaded immunonanoparticles. J Control Release 2008;127(3):219-230.

(34) Harush-Frenkel O, Rozentur E, Benita S, Altschuler Y. Surface charge of nanoparticles determines their endocytic and transcytotic pathway in polarized MDCK cells. Biomacromolecules 2008;9(2):435-443.

(35) Tamilvanan S, Klang S, Benita S. Safety assessments of stearylamine-based cationic emulsion as ocular drug vehicle. Indian Drugs 2008;45(8):635-642.

(36) Harush-Frenkel O, Altschuler Y, Benita S. Nanoparticle-cell interactions: Drug delivery implications. Crit Rev Ther Drug Carrier Syst 2008;25(6):485-544.

(37) Harush-Frenkel O, Debotton N, Benita S, Altschuler Y. Targeting of nanoparticles to the clathrin-mediated endocytic pathway. Biochem Biophys Res Commun 2007;353(1):26-32.

(38) Goldstein D, Sader O, Benita S. Influence of oil droplet surface charge on the performance of antibody-emulsion conjugates. Biomed Pharmacother 2007;61(1):97-103.

(39) Goldstein D, Gofrit O, Nyska A, Benita S. Anti-HER2 cationic immunoemulsion as a potential targeted drug delivery system for the treatment of prostate cancer. Cancer Res 2007;67(1):269-275.

(40) Tamilvanan S, Abdulrazik M, Benita S. Non-systemic delivery of topical brimonidine to the brain: A neuro-ocular tissue distribution study. J Drug Targeting 2006;14(10):670-679.

(41) Abdulrazik M, Behar-Cohen F, Benita S. Drug delivery systems for enhanced ocular absorption. Enhancement in Drug Delivery; 2006. p. 490-525.

(42) Goldstein D, Nassar T, Lambert G, Kadouche J, Benita S. The design and evaluation of a novel targeted drug delivery system using cationic emulsion - Antibody conjugates. J Control Release 2005;108(2-3):418-432.

(43) Springer C, Benita S, Sherman Y, Gursoy N, Gilhar D, Avital A. Poly-lactic-glycolic acid microspheres: A biodegradable marker for the diagnosis of aspiration in hamsters. Pediatr Res 2005;58(3):537-541.

(44) Tamilvanan S, Schmidt S, Müller RH, Benita S. In vitro adsorption of plasma proteins onto the surface (charges) modified-submicron emulsions for intravenous administration. Eur J Pharm Biopharm 2005;59(1):1-7.

(45) Goldstein D, Lambert G, Puisieux F, Benita S. Colloid drug delivery systems: A response to therapeutic expectations arising from biotechnological advances? Ann Pharm Fr 2005;63(1):90-104.

(46) Bivas-Benita M, Oudshoorn M, Romeijn S, Van Meijgaarden K, Koerten H, Van Der Meulen H, et al. Cationic submicron emulsions for pulmonary DNA immunization. J Control Release 2004;100(1):145-155.

(47) Tamilvanan S, Benita S. The potential of lipid emulsion for ocular delivery of lipophilic drugs. Eur J Pharm Biopharm 2004;58(2):357-368.

(48) Yang S, Gursoy RN, Lambert G, Benita S. Enhanced Oral Absorption of Paclitaxel in a Novel Self-Microemulsifying Drug Delivery System with or without Concomitant Use of P-Glycoprotein Inhibitors. Pharm Res 2004;21(2):261-270.

(49) Gursoy RN, Benita S. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother 2004;58(3):173-182.

(50) Brzezinski A, Stern T, Arbel R, Rahav G, Benita S. Efficacy of a novel pH-buffering tampon in preserving the acidic vaginal pH during menstruation. Int J Gynecol Obstet 2004;85(3):298-300.

(51) Rabinovich-Guilatt L, Couvreur P, Lambert G, Goldstein D, Benita S, Dubernet C. Extensive surface studies help to analyse zeta potential data: The case of cationic emulsions. Chem Phys Lipids 2004;131(1):1-13.

(52) Teixeira H, Dubernet C, Chacun H, Rabinovich L, Boutet V, Deverre JR, et al. Cationic emulsions improves the delivery of oligonucleotides to leukemic P388/ADR cells in ascite. J Control Release 2003;89(3):473-482.

(53) Gursoy N, Garrigue J-, Razafindratsita A, Lambert G, Benita S. Excipient Effects on in Vitro Cytotoxicity of a Novel Paclitaxel Self-Emulsifying Drug Delivery System. J Pharm Sci 2003;92(12):2411-2418.

(54) Stern T, Lamas MC, Benita S. Design and characterization of protein-based microcapsules as a novel catamenial absorbent system. Int J Pharm 2002;242(1-2):185-190.

(55) Abdulrazik M, Tamilvanan S, Khoury K, Benita S. Ocular delivery of cyclosporin A II. Effect of submicron emulsion's surface charge on ocular distribution of topical cyclosporin A. STP Pharma Sci 2001;11(6):427-432.

(56) Tamilvanan S, Khoury K, Gilhar D, Benita S. Ocular delivery of cyclosporin A I. Design and characterization of cyclosporin A-loaded positively-charged submicron emulsion. STP Pharma Sci 2001;11(6):421-426.

(57) Teixeira H, Rosilio V, Laigle A, Lepault J, Erk I, Scherman D, et al. Characterization of oligonucleotide/lipid interactions in submicron cationic emulsions: Influence of the cationic lipid structure and the presence of PEG-lipids. Biophys Chem 2001;92(3):169-181.

(58) Teixeira H, Dubernet C, Rosilio V, Laigle A, Deverre JR, Scherman D, et al. Factors influencing the oligonucleotides release from O-W submicron cationic emulsions. J Control Release 2001;70(1-2):243-255.

(59) Gershanik T, Haltner E, Lehr C-, Benita S. Charge-dependent interaction of self-emulsifying oil formulations with Caco-2 cells monolayers: Binding, effects on barrier function and cytotoxicity. Int J Pharm 2000;211(1-2):29-36.

(60) Klang S, Abdulrazik M, Benita S. Influence of emulsion droplet surface charge on indomethacin ocular tissue distribution. Pharm Dev Technol 2000;5(4):521-532.

(61) Soma CE, Dubernet C, Barratt G, Benita S, Couvreur P. Investigation of the role of macrophages on the cytotoxicity of doxorubicin and doxorubicin-loaded nanoparticles on M5076 cells in vitro. J Control Release 2000;68(2):283-289.

(62) Gershanik T, Benita S. Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur J Pharm Biopharm 2000;50(1):179-188.

(63) Yang SC, Benita S. Enhanced absorption and drug targeting by positively charged submicron emulsions. Drug Dev Res 2000;50(3-4):476-486.

(64) Emilienne Soma C, Dubernet C, Bentolila D, Benita S, Couvreur P. Reversion of multidrug resistance by co-encapsulation of doxorubicin and cyclosporin A in polyalkylcyanoacrylate nanoparticles. Biomaterials 2000;21(1):1-7.

(65) Naveh N, Weissman C, Muchtar S, Benita S, Mechoulam R. A submicron emulsion of HU-211, a synthetic cannabinoid, reduces intraocular pressure in rabbits. Graefe's Arch Clin Exp Ophthalmol 2000;238(4):334-338.

(66) Teixeira H, Dubernet C, Rosilio V, Benita S, Lepault J, Erk I, et al. New bicompartmental structures are observed when stearylamine is mixed with triglyceride emulsions. Pharm Res 2000;17(10):1329-1332.

(67) Youenang Piemi MP, Korner D, Benita S, Marty J-. Positively and negatively charged submicron emulsions for enhanced topical delivery of antifungal drugs. J Control Release 1999;58(2):177-187.

(68) Teixeira H, Dubernet C, Puisieux F, Benita S, Couvreur P. Submicron cationic emulsions as a new delivery system for oligonucleotides. Pharm Res 1999;16(1):30-36.

(69) Cruaud O, Benita S, Benoit JP. The characterization and release kinetics evaluation of baclofen microspheres designed for intrathecal injection. Int J Pharm 1999;177(2):247-257.

(70) Benita S. Prevention of topical and ocular oxidative stress by positively charged submicron emulsion. Biomed Pharmacother 1999;53(4):193-206.

(71) Gershanik T, Benita S. Cyclosporine A absorption enhancement in perfused rat intestine by positively charged self-emulsifying oil formulations. Proc Control Release Soc 1999(26):913-914.

(72) Klang SH, Siganos CS, Benita S, Frucht-Pery J. Evaluation of a positively charged submicron emulsion of piroxicam on the rabbit corneum healing process following alkali burn. J Control Release 1999;57(1):19-27.

(73) Soma CE, Dubernet C, Barratt G, Nemati F, Appel M, Benita S, et al. Ability of doxorubicin-loaded nanoparticles to overcome multidrug resistance of tumor cells after their capture by macrophages. Pharm Res 1999;16(11):1710-1716.

(74) Gershanik T, Benzeno S, Benita S. Interaction of a self-emulsifying lipid drug delivery system with the everted rat intestinal mucosa as a function of droplet size and surface charge. Pharm Res 1998;15(6):863-869.

(75) Muchtar S, Abdulrazik M, Frucht-Pery J, Benita S. Ex-vivo permeation study of indomethacin from a submicron emulsion through albino rabbit cornea. J Control Release 1997;44(1):55-64.

(76) Gershanik T, Benzeno S, Benita S. Charge dependent interaction of self-emulsifying lipid drug delivery system with mucosa of everted rat intestine. PROC CONTROL RELEASE SOC 1997(24):321-322.

(77) Dubernet C, Teixeira H, Benita S, Couvreur P. Cationic emulsions as a novel antisense oligonucleotides delivery system. PROC CONTROL RELEASE SOC 1997(24):661-662.

(78) Pierre M, Piemi Y, Korner D, Benita S, Marty J-. Comparison of transdermal delivery profiles of miconazole in submicron emulsions by radioactivity or HPLC technique. PROC CONTROL RELEASE SOC 1997(24):1035-1036.

(79) Klang SH, Baszkin A, Benita S. The stability of piroxicam incorporated in a positively-charged submicron emulsion for ocular administration. Int J Pharm 1996;132(1-2):33-44.

(80) Klang SH, Siganos CS, Benita S, Frucht-Pery J. Piroxicam positively-charged emulsion protects against corneal alkali burn in a rabbit model. Invest Ophthalmol Vis Sci 1996;37(3).

(81) Gershanik T, Benita S. Positively charged self-emulsifying oil formulation for improving oral bioavailability of progesterone. Pharm Dev Technol 1996;1(2):147-157.

(82) Wehrle P, Korner D, Benita S. Sequential statistical optimization of a positively-charged submicron emulsion of miconazole. Pharm Dev Technol 1996;1(1):97-111.

(83) Domb AJ, Linden G, Polacheck I, Benita S. Nystatin-dextran conjugates: Synthesis and characterization. J Polym Sci Part A 1996;34(7):1229-1236.

(84) Ezra R, Benita S, Ginsburg I, Kohen R. Prevention of oxidative damage in fibroblast cell cultures and rat skin by positively-charged submicron emulsion of α-tocopherol. Eur J Pharm Biopharm 1996;42(4):291-298.

(85) Wehrle P, Magenheim B, Benita S. The influence of process parameters on the PLA nanoparticle size distribution, evaluated by means of factorial design. Eur J Pharm Biopharm 1995;41(1):19-26.

(86) Donbrow M, Hoffman A, Benita S. Gradation of microcapsule wall porosity by deposition of polymer mixtures (eudragit RL and eudragit RS). Phase separation of polymer mixtures and effects of external media and conditions on release. J Microencapsulation 1995;12(3):273-285.

(87) Domb AJ, Linden G, Polacheck I, Benita S. Synthesis and biological activity of nystatin-dextran conjugates. PROC CONTROL RELEASE SOC 1995(22):744-745.

(88) Levy MY, Polacheck I, Barenholz Y, Benita S. Efficacy Evaluation of a Novel Submicron Miconazole Emulsion in a Murine Cryptococcosis Model. Pharm Res 1995;12(2):223-230.

(89) Magalhaes NSS, Fessi H, Puisieux F, Benita S, Seiller M. An in vitro release kinetic examination and comparative evaluation between submicron emulsion and polylactic acid nanocapsules of clofibride. J Microencapsulation 1995;12(2):195-205.

(90) Muchtar S, Benita S. Emulsions as drug carriers for ophthalmic use. Colloids Surf A Physicochem Eng Asp 1994;91(C):181-190.

(91) Korner D, Benita S, Albrecht G, Baszkin A. Surface properties of mixed phospholipid-stearylamine monolayers and their interaction with a non-ionic surfactant (poloxamer). Colloids Surf B Biointerfaces 1994;3(1-2):101-109.

(92) Zeevi A, Klang S, Alard V, Brossard F, Benita S. The design and characterization of a positively charged submicron emulsion containing a sunscreen agent. Int J Pharm 1994;108(1):57-68.

(93) Naveh N, Muchtar S, Benita S. Pilocarpine Incorporated into a Submicron Emulsion Vehicle Causes an Unexpectedly Prolonged Ocular Hypotensive Effect in Rabbits. J Ocul Pharmacol 1994;10(3):509-520.

(94) KLANG SH, FRUCHT‐PERY J, HOFFMAN A, BENITA S. Physicochemical Characterization and Acute Toxicity Evaluation of a Positively‐charged Submicron Emulsion Vehicle. J Pharm Pharmacol 1994;46(12):986-993.

(95) Langerman L, Golomb E, Grant GJ, Benita S. Duration of spinal anaesthesia is determined by the partition coefficient of local anaesthetic. Br J Anaesth 1994;72(4):456-459.

(96) Levy MY, Schutze W, Fuhrer C, Benita S. Characterization of diazepam submicron emulsion interface: Role of oleic acid. J Microencapsulation 1994;11(1):79-92.

(97) Muchtar S, Levy MY, Benita S, Baszkin A. Penetration of amphoteric surfactants into phospholipid monolayers spread at the air-water interface. Colloids Surf B Biointerfaces 1993;1(3):149-155.

(98) Elbaz E, Zeevi A, Klang S, Benita S. Positively charged submicron emulsions - a new type of colloidal drug carrier. Int J Pharm 1993;96(1-3):R1-R6.

(99) Magenheim B, Levy MY, Benita S. A new in vitro technique for the evaluation of drug release profile from colloidal carriers - ultrafiltration technique at low pressure. Int J Pharm 1993;94(1-3):115-123.

(100) Benita S, Levy MY. Submicron emulsions as colloidal drug carriers for intravenous administration: Comprehensive physicochemical characterization. J Pharm Sci 1993;82(11):1069-1079.

(101) Golomb E, Langerman L, Benita S. Discrepancy between the development of tolerance to bupivacaine in extradural and spinal anaesthesia in rabbits. Br J Anaesth 1993;71(3):450-452.

(102) Kleinstern J, Markowitz E, Benita S. The effect of oil nature in o/w submicron emulsion on the oral absorption profile of physostigmine salicylate in rats. STP PHARMA SCI 1993;3(2):163-169.

(103) Santos Magalhaes NS, Benita S, Seiller M. Oral emulsions: Preparation and bioavailability. J Pharm Belg 1993;48(3):211-226.

(104) Levy MY, Polacheck I, Barenholz Y, Benita S. Efficacy evaluation of a novel submicron amphotericin b emulsion in murine candidiasis. Med Mycol 1993;31(3):207-218.

(105) Ammoury N, Dubrasquet M, Fessi H, Devissaguet J-, Puisieux F, Benita S. Indomethacin-loaded poly (d,l-lactide) nanocapsules protection from gastrointestinal ulcerations and anti-inflammatory activity evaluation in rats. Clin Mater 1993;13(1-4):121-130.

(106) Muchtar S, Almog S, Torracca MT, Saettone MF, Benita S. A submicron emulsion as ocular vehicle for delta-8-tetrahydro-cannabinol: Effect on intraocular pressure in rabbits. Ophthalmic Res 1992;24(3):142-149.

(107) Levy MY, Benita S, Baszkin A. Interactions of a non-ionic surfactant with mixed phospholipid-oleic acid monolayers. Studies under dynamic conditions. Colloids and Surfaces 1991;59(C):225-241.

(108) Magalhaes NSS, Cave G, Seiller M, Benita S. The stability and in vitro release kinetics of a clofibride emulsion. Int J Pharm 1991;76(3):225-237.

(109) Weingarten C, Santos Magalhaes NS, Baszkin A, Benita S, Seiller M. Interactions of a non-ionic ABA copolymer surfactant with phospholipid monolayers: Possible relevance to emulsion stabilization. Int J Pharm 1991;75(2-3):171-179.

(110) Langerman L, Golomb E, Benita S. Prolongation of the pharmacoligic effect of intrathecal meperidine by the use of a lipid solution of it. Anesth Analg 1991;72(5):635-638.

(111) Levy MY, Benita S. Short- and long-term stability assessment of a new injectable diazepam submicron emulsion. J PARENT SCI TECHNOL 1991;45(2):101-107.

(112) Magenheim B, Benita S. Nanoparticle characterization: A comprehensive physicochemical approach. STP PHARMA SCI 1991;1(4):221-241.

(113) Langerman L, Golomb E, Benita S. Spinal anesthesia: Significant prolongation of the pharmacologic effect of tetracaine with lipid solution of the agent. Anesthesiology 1991;74(1):105-107.

(114) Magalhaes NSS, Benita S, Baszkin A. Penetration of poly(oxyethylene)-poly (oxypropylene) block copolymer surfactant into soya phospholipid monolayers. Colloids and Surfaces 1991;52(C):195-206.

(115) Muchtar S, Levy MY, Sarig S, Benita S. Stability assessment of a fat emulsion prepared with an original mixture of purified phospholipids. STP PHARMA SCI 1991;1(2):130-136.

(116) Ammoury N, Fessi H, Devissaguet J-, Dubrasquet M, Benita S. Jejunal Absorption, Pharmacological Activity, and Pharmacokinetic Evaluation of Indomethacin-Loaded Poly(d,l-Lactide) and Poly(Isobutyl-Cyanoacrylate) Nanocapsules in Rats. Pharm Res 1991;8(1):101-105.

(117) Rubinstein A, Pathak YV, Kleinstern J, Reches A, Benita S. In vitro release and intestinal absorption of physostigmine salicylate from submicron emulsions. J Pharm Sci 1991;80(7):643-647.

(118) Levy MY, Benita S. Drug release from submicronized o/w emulsion: a new in vitro kinetic evaluation model. Int J Pharm 1990;66(1-3):29-37.

(119) Pathak YV, Rubinstein A, Benita S. Enhanced stability of physostigmine salicylate in submicron o/w emulsion. Int J Pharm 1990;65(3):169-175.

(120) Benita S. From university applied research to hightech industry-policy and philosophy. The Hebrew University of Jerusalem model. SCI TECH PRAT PHARM 1990;6(7):520-521.

(121) Benita S, Barkai A, Pathak YV. Effect of drug loading extent on the in vitro release kinetic behaviour of nifedipine from polyacrylate microspheres. J Control Release 1990;12(3):213-222.

(122) Donbrow M, Hoffman A, Benita S. Phase separation modulation and aggregation prevention: Mechanism of the non-solvent addition method in the presence and absence of polyisobutylene as an additive. J Microencapsulation 1990;7(1):1-15.

(123) Barkai A, Pathak YV, Benita S. Polyacrylate (eudragit retard) microspheres for oral controlled release of nifedipine. I. Formulation design and process optimization. Drug Dev Ind Pharm 1990;16(13):2057-2075.

(124) Ammoury N, Fessi H, Devissaguet JP, Puisieux F, Benita S. In vitro release kinetic pattern of indomethacin from Poly(D, L‐Lactide) nanocapsules. J Pharm Sci 1990;79(9):763-767.

(125) Langerman L, Chaimsky G, Golomb E, Tverskoy M, Kook AI, Benita S. A rabbit model for evaluation of spinal anesthesia: Chronic cannulation of the subarachnoid space. Anesth Analg 1990;71(5):529-535.

(126) Fessi H, Puisieux F, Devissaguet JP, Ammoury N, Benita S. Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int J Pharm 1989;55(1):R1-R4.

(127) Levy MY, Benita S. Design and characterization of a submicronized o/w emulsion of diazepam for parenteral use. Int J Pharm 1989;54(2):103-112.

(128) Schutz M, Benita S. The design and in vitro release characterization of human cross-linked haemoglobin microcapsules containing doxorubicin for potential chemoembolization use. J Dispersion Sci Technol 1989;10(3):219-239.

(129) Friedman D, Pathak YV, Benita S. Micronized emulsion for controlled release of physostigmine after oral administration. Part I. Formulation design. Drug Des Deliv 1989;4(2):135-142.

(130) Benita S, Friedman D, Pathak YV, Kleinstern J. Micronized emulsion for controlled release of physostigmine after oral administration. Part II. Release characteristics and pharmacological evaluation. Drug Des Deliv 1989;4(2):143-153.

(131) Levy MY, Langerman L, Gottschalk-Sabag S, Benita S. Side-Effect Evaluation of a New Diazepam Formulation: Venous Sequela Reduction Following Intravenous (iv) Injection of a Diazepam Emulsion in Rabbits. Pharm Res 1989;6(6):510-516.

(132) Andrieu V, Fessi H, Dubrasquet M, Devissaguet J-, Puisieux F, Benita S. Pharmacokinetic evaluation of indomethacin nanocapsules. Drug Des Deliv 1989;4(4):295-302.

(133) Babay D, Hoffman A, Benita S. Design and release kinetic pattern evaluation of indomethacin microspheres intended for oral administration. Biomaterials 1988;9(6):482-488.

(134) Donbrow M, Hoffman A, Benita S. Variation of Population Release Kinetics in Polydisperse Multiparticulate Systems (Microcapsules, Microspheres, Droplets, Cells) with Heterogeneity of One, Two or Three Parameters in the Population of Individuals. J Pharm Pharmacol 1988;40(2):93-96.

(135) Benita S, Babay D, Hoffman A, Donbrow M. Relation Between Individual and Ensemble Release Kinetics of Indomethacin from Microspheres. Pharm Res 1988;5(3):178-182.

(136) Sawaya A, Fickat R, Benoit JP, Puisieux F, Benita S. Ion-exchange albumin microcapsules of doxorubicin: An in vitro release kinetic evaluation. J Microencapsulation 1988;5(3):255-267.

(137) Dor P, Benita S, Levesque G. Cellulose hydrogen phthalate. A coating polymer in controlled release dosage forms. Pharm Acta Helv 1987;62(9):255-261.

(138) Shani J, Benita S, Abdulrazik M, Yerushalmi A. Efficacy of sustained-release radioprotective drugs in vivo. Z Naturforsch Sect C J Biosci 1987;42(11-12):1323-1327.

(139) Friedman D, Benita S. A mathematical morel for drug release from 0/w emulsions: Application to controlled release morphine emulsions. Drug Dev Ind Pharm 1987;13(9-11):2067-2085.

(140) Sawaya A, Benoit J‐, Benita S. Binding mechanism of doxorubicin in lon‐exchange albumin microcapsules. J Pharm Sci 1987;76(6):475-480.

(141) Benita S, Friedman D, Wienstock M. Evaluation of the reversal of flunitrazepam intoxication by a controlled-release physostigmine emulsion. SCI TECH PRAT PHARM 1986;2(20-21):923-926.

(142) Benita S, Friedman D, Weinstock M. Physostigmine emulsion: a new injectable controlled release delivery system. Int J Pharm 1986;30(1):47-55.

(143) Hoffman A, Donbrow M, Benita S. Direct measurements on individual microcapsule dissolution as a tool for determination of release mechanism. J Pharm Pharmacol 1986;38(10):764-766.

(144) Benita S, Friedman D, Weinstock M. Pharmacological evaluation of an injectable prolonged release emulsion of physostigmine in rabbits. J Pharm Pharmacol 1986;38(9):653-658.

(145) Benita S, Zouai O, Benoit J‐. 5‐fluorouracil: Carnauba wax microspheres for chemoembolization: An in vitro evaluation. J Pharm Sci 1986;75(9):847-851.

(146) Benita S, Dor P, Aronhime M, Marom G. Permeability and mechanical properties of a new polymer: cellulose hydrogen phthalate. Int J Pharm 1986;33(1-3):71-80.

(147) Gross ST, Hoffman A, Donbrow M, Benita S. Fundamentals of release mechanism interpretation in multiparticulate systems: the prediction of the commonly observed release equations from statistical population models for particle ensembles. Int J Pharm 1986;29(2-3):213-222.

(148) Hoffman A, Donbrow M, Gross ST, Benita S, Bahat R. Fundamentals of release mechanism interpretation in multiparticulate systems: determination of substrate release from single microcapsules and relation between individual and ensemble release kinetics. Int J Pharm 1986;29(2-3):195-211.

(149) Benita S, Hoffman A, Donbrow M. Polyacrylate resin (eudragit retard) microcapsules as a controlled release drug delivery system improved non-solvent addition phase separation process. J Microencapsulation 1985;2(3):207-222.

(150) BENITA S, HOFFMAN A, DONBROW M. Microencapsulation of paracetamol using polyacrylate resins (Eudragit Retard), kinetics of drug release and evaluation of kinetic model. J Pharm Pharmacol 1985;37(6):391-395.

(151) Benita S. Kinetic model identification of drug release from microcapsules using the nonlinear regression search procedure. Appl Biochem Biotechnol 1984;10(1-3):255-258.

(152) Donbrow M, Benita S, Hoffman A. Microencapsulation of dichromate and paracetamol with Eudragit Retard polymers using phase separation by nonsolvent addition. Appl Biochem Biotechnol 1984;10(1-3):245-249.

(153) Benita S, Benoit JP, Puisieux F, Thies C. Characterization of drug‐loaded poly(d,l‐lactide) microspheres. J Pharm Sci 1984;73(12):1721-1724.

(154) Benita S, Poly PA, Puisieux F, Delattre J. Radiopaque liposomes: Effect of formulation conditions on encapsulation efficiency. J Pharm Sci 1984;73(12):1751-1755.

(155) Benita S, Shani J, Abdulrazik M, Samuni A. Controlled release of radioprotective agents from matrix tablets—effect of preparative conditions on release rates. J Pharm Pharmacol 1984;36(4):222-228.

(156) Benita S, Fickat R, Benoǐt JP, Bonnemain B, Samaille JP, Madoulé P. Biodegradable Cross-linked albumin microcapsules for embolization. J Microencapsulation 1984;1(4):317-327.

(157) Benita S, Plenecassagne JD, Cavé G, Drouin D, Hao Dong PL, Sincholle D. Pilocarpine hydrochloride liposomes: Characterization in vitro and preliminary evaluation in vivo in rabbit Eye. J Microencapsulation 1984;1(3):203-216.

(158) Abdulrazik M, Shani J, Benita S, Samuni A, Donbrow M, Yerushalmi A. Formulation for slow release of oral radiation-protection drugs. Int J Nucl Med Biol 1984;11(1):53-54.

(159) DONBROW M, BENITA S. Release kinetics of sparingly soluble drugs from ethyl cellulose‐walled microcapsules: salicylamide microcapsules. J Pharm Pharmacol 1982;34(9):547-551.

(160) BENITA S, DONBROW M. Release kinetics of sparingly soluble drugs from ethyl cellulose‐walled microcapsules: theophylline microcapsules. J Pharm Pharmacol 1982;34(2):77-82.

(161) Benita S, Donbrow M. Effect of polyisobutylene on ethylcellulose‐walled microcapsules: Wall structure and thickness of salicylamide and theophylline microcapsules. J Pharm Sci 1982;71(2):205-210.

(162) Benita S, Donbrow M. Dissolution rate control of the release kinetics of water-soluble compounds from ethyl cellulose film-type microcapsules. Int J Pharm 1982;12(2-3):251-264.

(163) Puisieux F, Benita S. Towards a new galenic dosage form, the liposomes? Biomed Pharmacother 1982;36(1):4-13.

(164) Benita S, Donbrow M. Coacervation of ethyl cellulose: The role of polyisobutylene and the effect of its concentration. J Colloid Interface Sci 1980;77(1):102-109.