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School of Pharmacy : Benny Ofra


 Last updated February 2023 - School of Pharmacy

List of Publications

(1) Dahan T, Nassar S, Yajuk O, Steinberg E, Benny O, Abudi N, et al. Chronic Intermittent Hypoxia during Sleep Causes Browning of Interscapular Adipose Tissue Accompanied by Local Insulin Resistance in Mice. Int J Mol Sci 2022;23(24).

(2) Brill-Karniely Y, Schwob O, Benny O. The aspect ratio effect on the cytotoxicity of inert nano-particles flips depending on particle thickness, and is one of the reasons for the literature inconsistency. Nanoscale Adv 2022;4(24):5257-5269.

(3) Friedman N, Merims S, Elia J, Benny O. Ex-vivo Skin Permeability Tests of Nanoparticles for Microscopy Imaging. Bio-Protoc 2022;12(7).

(4) Fluksman A, Lafuente A, Li Z, Sort J, Lope-Piedrafita S, Esplandiu MJ, et al. Efficient Tumor Eradication at Ultralow Drug Concentration via Externally Controlled and Boosted Metallic Iron Magnetoplasmonic Nanocapsules. ACS Nano 2022.

(5) Esa R, Steinberg E, Dagan A, Yekhtin Z, Tischenko K, Benny O. Newly synthesized methionine aminopeptidase 2 inhibitor hinders tumor growth. Drug Deliv Transl Res 2022.

(6) Goldstein Y, Tischenko K, Brill‐karniely Y, Benny O. Enhanced biomechanically mediated “phagocytosis” in detached tumor cells. Biomedicines 2021;9(8).

(7) Friedman N, Dagan A, Elia J, Merims S, Benny O. Physical properties of gold nanoparticles affect skin penetration via hair follicles. Nanomed Nanotechnol Biol Med 2021;36.

(8) Minkowicz L, Dagan A, Uvarov V, Benny O. Controlling calcium carbonate particle morphology, size, and molecular order using silicate. Mater 2021;14(13).

(9) Goldstein Y, Spitz S, Turjeman K, Selinger F, Barenholz Y, Ertl P, et al. Breaking the third wall: Implementing 3d-printing technics to expand the complexity and abilities of multi-organ-on-a-chip devices. Micromachines 2021;12(6).

(10) Amoyav B, Goldstein Y, Steinberg E, Benny O. 3D printed microfluidic devices for drug release assays. Pharmaceutics 2021;13(1):1-14.

(11) Steinberg E, Fluksman A, Zemmour C, Tischenko K, Karsch-Bluman A, Brill-Karniely Y, et al. Low dose amiodarone reduces tumor growth and angiogenesis. Sci Rep 2020;10(1).

(12) Steinberg E, Orehov N, Tischenko K, Schwob O, Zamir G, Hubert A, et al. Rapid clearing for high resolution 3D imaging of ex vivo pancreatic cancer spheroids. Int J Mol Sci 2020;21(20):1-18.

(13) Fluksman A, Steinberg E, Orehov N, Shai E, Lahiani A, Katzhendler J, et al. Integrin α2β1-Targeted Self-Assembled Nanocarriers for Tumor Bioimaging. ACS Appl Bio Mater 2020;3(9):6059-6070.

(14) Esa R, Steinberg E, Dror D, Schwob O, Khajavi M, Maoz M, et al. The role of methionine aminopeptidase 2 in lymphangiogenesis. Int J Mol Sci 2020;21(14).

(15) Karsch-Bluman A, Benny O. Necrosis in the Tumor Microenvironment and Its Role in Cancer Recurrence. Adv Exp Med Biol 2020;1225:89-98.

(16) Brill-Karniely Y, Dror D, Duanis-Assaf T, Goldstein Y, Schwob O, Millo T, et al. Triangular correlation (TrC) between cancer aggressiveness, cell uptake capability, and cell deformability. Sci Adv 2020;6(3).

(17) Abramov E, Schwob O, Benny O. Film- and ointment-based delivery systems for the transdermal delivery of TNP-470. Polym Adv Technol 2019;30(10):2586-2595.

(18) Karsch-Bluman A, Avraham S, Assayag M, Schwob O, Benny O. Encapsulated carbenoxolone reduces lung metastases. Cancers 2019;11(9).

(19) Fluksman A, Benny O. A robust method for critical micelle concentration determination using coumarin-6 as a fluorescent probe. Anal Methods 2019;11(30):3810-3818.

(20) Karsch-Bluman A, Feiglin A, Arbib E, Stern T, Shoval H, Schwob O, et al. Tissue necrosis and its role in cancer progression. Oncogene 2019;38(11):1920-1935.

(21) Amoyav B, Benny O. Microfluidic based fabrication and characterization of highly porous polymeric microspheres. Polym 2019;11(3).

(22) Ella E, Harel Y, Abraham M, Wald H, Benny O, Karsch-Bluman A, et al. Matrix metalloproteinase 12 promotes tumor propagation in the lung. J Thorac Cardiovasc Surg 2018;155(5):2164-2175.e1.

(23) Amoyav B, Benny O. Controlled and tunable polymer particles’ production using a single microfluidic device. Appl Nanosci (Switzerland) 2018;8(4):905-914.

(24) Ehrenberg M, Benny O. Evolving multidimensional pharmacological approaches to CNV therapy in AMD. Curr Eye Res 2018;43(2):147-154.

(25) Lazarovici P, Lahiani A, Gincberg G, Haham D, Fluksman A, Benny O, et al. Nerve growth factor-induced angiogenesis: 1. Endothelial cell tube formation assay. Methods Mol Biol 2018;1727:239-250.

(26) Shoval H, Karsch-Bluman A, Brill-Karniely Y, Stern T, Zamir G, Hubert A, et al. Tumor cells and their crosstalk with endothelial cells in 3D spheroids. Sci Rep 2017;7(1).

(27) Stern T, Kaner I, Laser Zer N, Shoval H, Dror D, Manevitch Z, et al. Rigidity of polymer micelles affects interactions with tumor cells. J Control Release 2017;257:40-50.

(28) Karsch-Bluman A, Amoyav B, Friedman N, Shoval H, Schwob O, Ella E, et al. High mobility group box 1 antagonist limits metastatic seeding in the lungs via reduction of cell-cell adhesion. Oncotarget 2017;8(20):32706-32721.

(29) Licht T, Rothe G, Kreisel T, Wolf B, Benny O, Rooney AG, et al. VEGF preconditioning leads to stem cell remodeling and attenuates age-related decay of adult hippocampal neurogenesis. Proc Natl Acad Sci U S A 2016;113(48):E7828-E7836.

(30) Ehrenberg M, Ehrenberg S, Schwob O, Benny O. Murine fundus fluorescein angiography: An alternative approach using a handheld camera. Exp Eye Res 2016;148:74-78.

(31) Abramov E, Cassiola F, Schwob O, Karsh-Bluman A, Shapero M, Ellis J, et al. Cellular mechanism of oral absorption of solidified polymer micelles. Nanomed Nanotechnol Biol Med 2015;11(8):1993-2002.

(32) Birsner AE, Benny O, D'Amato RJ. The corneal micropocket assay: A model of angiogenesis in the mouse eye. J Visualized Exp 2014(90).

(33) Adini I, Ghosh K, Adini A, Chi Z-, Yoshimura T, Benny O, et al. Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment. J Clin Invest 2014;124(1):425-436.

(34) Momic T, Katzehendler J, Benny O, Lahiani A, Cohen G, Noy E, et al. Vimocin and vidapin, cyclic KTS peptides, are dual antagonists of α1β1/α2β1 integrins with antiangiogenic activity. J Pharmacol Exp Ther 2014;350(3):506-519.

(35) Panigrahy D, Kalish BT, Huang S, Bielenberg DR, Le HD, Yang J, et al. Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci U S A 2013;110(33):13528-13533.

(36) Yoshimura T, Benny O, Bazinet L, D'Amato RJ. Suppression of Autoimmune Retinal Inflammation by an Antiangiogenic Drug. PLoS ONE 2013;8(6).

(37) Adini A, Adini I, Ghosh K, Benny O, Pravda E, Hu R, et al. The stem cell marker prominin-1/CD133 interacts with vascular endothelial growth factor and potentiates its action. Angiogenesis 2013;16(2):405-416.

(38) Panigrahy D, Edin ML, Lee CR, Huang S, Bielenberg DR, Butterfield CE, et al. Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. J Clin Invest 2012;122(1):178-191.

(39) Shulman M, Cohen M, Soto-Gutierrez A, Yagi H, Wang H, Goldwasser J, et al. Enhancement of naringenin bioavailability by complexation with hydroxypropoyl-β-cyclodextrin. PLoS ONE 2011;6(4).

(40) Becker CM, Beaudry P, Funakoshi T, Benny O, Zaslavsky A, Zurakowski D, et al. Circulating endothelial progenitor cells are up-regulated in a mouse model of endometriosis. Am J Pathol 2011;178(4):1782-1791.

(41) Benny O, Nakai K, Yoshimura T, Bazinet L, Akula JD, Nakao S, et al. Broad spectrum antiangiogenic treatment for ocular neovascular diseases. PLoS ONE 2010;5(9):1-14.

(42) Arai T, Benny O, Joki T, Menon LG, Machluf M, Abe T, et al. Novel local drug delivery system using thermoreversible gel in combination with polymeric microspheres or liposomes. Anticancer Res 2010;30(4):1057-1064.

(43) Baruch L, Benny O, Gilert A, Ukobnik M, Ben Itzhak O, MacHluf M. Alginate-PLL cell encapsulation system Co-entrapping PLGA-microspheres for the continuous release of anti-inflammatory drugs. Biomed Microdevices 2009;11(5):1103-1113.

(44) Benny O, Menon LG, Ariel G, Goren E, Kim S-, Stewman C, et al. Local delivery of poly lactic-co-glycolic acid microspheres containing imatinib mesylate inhibits intracranial xenograft glioma growth. Clin Cancer Res 2009;15(4):1222-1231.

(45) Benny O, Pakneshan P. Novel technologies for antiangiogenic drug delivery in the brain. Cell Adhesion Migr 2009;3(2):224-229.

(46) Fainaru O, Adini I, Benny O, Bazinet L, Pravda E, D'Amato R, et al. Doxycycline induces membrane expression of VE-cadherin on endothelial cells and prevents vascular hyperpermeability. FASEB J 2008;22(10):3728-3735.

(47) Nakai K, Fainaru O, Bazinet L, Pakneshan P, Benny O, Pravda E, et al. Dendritic cells augment choroidal neovascularization. Invest Ophthalmol Vis Sci 2008;49(8):3666-3670.

(48) Benny O, Fainaru O, Adini A, Cassiola F, Bazinet L, Adini I, et al. An orally delivered small-molecule formulation with antiangiogenic and anticancer activity. Nat Biotechnol 2008;26(7):799-807.

(49) Benny O, Kim S-, Gvili K, Radzishevsky IS, Mor A, Verduzco L, et al. In vivo fate and therapeutic efficacy of PF-4/CTF microspheres in an orthotopic human glioblastoma model. FASEB J 2008;22(2):488-499.

(50) Fainaru O, Adini A, Benny O, Adini I, Short S, Bazinet L, et al. Dendritic cells support angiogenesis and promote lesion growth in a murine model of endometriosis. FASEB J 2008;22(2):522-529.

(51) Duvshani-Eshet M, Benny O, Morgenstern A, Machluf M. Therapeutic ultrasound facilitates antiangiogenic gene delivery and inhibits prostate tumor growth. Mol Cancer Ther 2007;6(8):2371-2382.

(52) Gvili K, Benny O, Danino D, Machluf M. Poly(D,L-lactide-co-glycolide acid) nanoparticles for DNA delivery: Waiving preparation complexity and increasing efficiency. Biopolymers 2007;85(5-6):379-391.

(53) Benny O, Duvshani-Eshet M, Cargioli T, Bello L, Bikfalvi A, Carroll RS, et al. Continuous Delivery of Endogenous Inhibitors from Poly (Lactic-Co-Glycolic Acid) Polymeric Microspheres Inhibits Glioma Tumor Growth. Clin Cancer Res 2005;11(2):768-776.

(54) Seagal J, Edry E, Keren Z, Leider N, Benny O, Machluf M, et al. A Fail-safe Mechanism for Negative Selection of Isotype-switched B Cell Precursors Is Regulated by the Fas/FasL Pathway. J Exp Med 2003;198(10):1609-1619.