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School of Pharmacy : Blum Galia


 Last updated December 2021 - School of Pharmacy

List of Publications

(1) Jacob Berger A, Gigi E, Kupershmidt L, Meir Z, Gavert N, Zwang Y, et al. IRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy. Nature Cancer 2021;2(10):1055-1070.

(2) Blum G, Verhelst SHL, Ma X. Editorial: Development and Applications of New Activity-Based Probes. Front Chem 2021;9.

(3) Meka SRK, Younis T, Reich E, Elayyan J, Kumar A, Merquiol E, et al. TNFα expression by Porphyromonas gingivalis-stimulated macrophages relies on Sirt1 cleavage. J Periodontal Res 2021;56(3):535-546.

(4) Gangadevi S, Badavath VN, Thakur A, Yin N, De Jonghe S, Acevedo O, et al. Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19. J Phys Chem Lett 2021;12(7):1793-1802.

(5) Oelschlaegel D, Sadan TW, Salpeter S, Krug S, Blum G, Schmitz W, et al. Cathepsin inhibition modulates metabolism and polarization of tumor-associated macrophages. Cancers 2020;12(9):1-22.

(6) Badavath VN, Kumar A, Samanta PK, Maji S, Das A, Blum G, et al. Determination of potential inhibitors based on isatin derivatives against SARS-CoV-2 main protease (mpro): a molecular docking, molecular dynamics and structure-activity relationship studies. J Biomol Struct Dyn 2020.

(7) Weiss-Sadan T, Maimoun D, Oelschlagel D, Kaschani F, Misiak D, Gaikwad H, et al. Cathepsins drive anti-inflammatory activity by regulating autophagy and mitochondrial dynamics in macrophage foam cells. Cell Physiol Biochem 2019;53(3):550-572.

(8) Weiss-Sadan T, Ben-Nun Y, Maimoun D, Merquiol E, Abd-Elrahman I, Gotsman I, et al. A theranostic cathepsin activity-based probe for noninvasive intervention in cardiovascular diseases. Theranostics 2019;9(20):5731-5738.

(9) Weiss-Sadan T, Itzhak G, Kaschani F, Yu Z, Mahameed M, Anaki A, et al. Cathepsin L regulates metabolic networks controlling rapid cell growth and proliferation. Mol Cell Proteomics 2019;18(7):1330-1344.

(10) Meena NK, Pattanayak SP, Ben-Nun Y, Benhamron S, Kumar S, Merquiol E, et al. mTORC1 activation in B cells confers impairment of marginal zone microarchitecture by exaggerating cathepsin activity. Immunology 2018;155(4):505-518.

(11) Gibori H, Eliyahu S, Krivitsky A, Ben-Shushan D, Epshtein Y, Tiram G, et al. Amphiphilic nanocarrier-induced modulation of PLK1 and MIR-34a leads to improved therapeutic response in pancreatic cancer. Nat Commun 2018;9(1).

(12) Tsvirkun D, Ben-Nun Y, Merquiol E, Zlotver I, Meir K, Weiss-Sadan T, et al. CT Imaging of Enzymatic Activity in Cancer Using Covalent Probes Reveal a Size-Dependent Pattern. J Am Chem Soc 2018;140(38):12010-12020.

(13) Gaikwad HK, Tsvirkun D, Ben-Nun Y, Merquiol E, Popovtzer R, Blum G. Molecular Imaging of Cancer Using X-ray Computed Tomography with Protease Targeted Iodinated Activity-Based Probes. Nano Lett 2018;18(3):1582-1591.

(14) Blau R, Epshtein Y, Pisarevsky E, Tiram G, Dangoor SI, Yeini E, et al. Image-guided surgery using near-infrared Turn-ON fluorescent nanoprobes for precise detection of tumor margins. Theranostics 2018;8(13):3437-3460.

(15) Ben-Nun Y, Fichman G, Adler-Abramovich L, Turk B, Gazit E, Blum G. Cathepsin nanofiber substrates as potential agents for targeted drug delivery. J Control Release 2017;257:60-67.

(16) Amit U, Kain D, Wagner A, Sahu A, Nevo-Caspi Y, Gonen N, et al. New role for interleukin-13 receptor α1 in myocardial homeostasis and heart failure. J Am Heart Assoc 2017;6(5).

(17) Weiss-Sadan T, Gotsman I, Blum G. Cysteine proteases in atherosclerosis. FEBS J 2017;284(10):1455-1472.

(18) Barkan Y, Levinman M, Veprinsky-Zuzuliya I, Tsach T, Merqioul E, Blum G, et al. Comparative evaluation of polycyanoacrylates. Acta Biomater 2017;48:390-400.

(19) Alishekevitz D, Gingis-Velitski S, Kaidar-Person O, Gutter-Kapon L, Scherer SD, Raviv Z, et al. Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3. Cell Rep 2016;17(5):1344-1356.

(20) Abd-Elrahman I, Kosuge H, Sadan TW, Ben-Nun Y, Meir K, Rubinstein C, et al. Cathepsin activity-based probes and inhibitor for preclinical atherosclerosis imaging and macrophage depletion. PLoS ONE 2016;11(8).

(21) Abu-Fanne R, Maraga E, Abd-Elrahman I, Hankin A, Blum G, Abdeen S, et al. αDefensins induce a post-translational modification of low density lipoprotein (LDL) that promotes atherosclerosis at normal levels of plasma cholesterol. J Biol Chem 2016;291(6):2777-2786.

(22) Shaulov-Rotem Y, Merquiol E, Weiss-Sadan T, Moshel O, Salpeter S, Shabat D, et al. A novel quenched fluorescent activity-based probe reveals caspase-3 activity in the endoplasmic reticulum during apoptosis. Chem Sci 2016;7(2):1322-1337.

(23) Abd-Elrahman I, Meir K, Kosuge H, Ben-Nun Y, Sadan TW, Rubinstein C, et al. Characterizing cathepsin activity and macrophage subtypes in excised human carotid plaques. Stroke 2016;47(4):1101-1108.

(24) Salpeter SJ, Pozniak Y, Merquiol E, Ben-Nun Y, Geiger T, Blum G. A novel cysteine cathepsin inhibitor yields macrophage cell death and mammary tumor regression. Oncogene 2015;34(50):6066-6078.

(25) Riahi Y, Kaiser N, Cohen G, Abd-Elrahman I, Blum G, Shapira OM, et al. Foam cell-derived 4-hydroxynonenal induces endothelial cell senescence in a TXNIP-dependent manner. J Cell Mol Med 2015;19(8):1887-1899.

(26) Fahham D, Merquiol E, Gilon T, Marx G, Blum G. Insoluble fibrinogen particles for harvesting and expanding attachment-dependent cells and for trapping suspended cancer cells in the presence of blood. Biomed Mater 2015;10(2).

(27) Ben-Aderet L, Merquiol E, Fahham D, Kumar A, Reich E, Ben-Nun Y, et al. Detecting cathepsin activity in human osteoarthritis via activity-based probes. Arthritis Res Ther 2015;17(1).

(28) Ben-Nun Y, Merquiol E, Brandis A, Turk B, Scherz A, Blum G. Photodynamic quenched cathepsin activity based probes for cancer detection and macrophage targeted therapy. Theranostics 2015;5(8):847-862.

(29) Ben-Mordechai T, Holbova R, Landa-Rouben N, Harel-Adar T, Feinberg MS, Abd Elrahman I, et al. Macrophage subpopulations are essential for infarct repair with and without stem cell therapy. J Am Coll Cardiol 2013;62(20):1890-1901.

(30) Salpeter SJ, Blum G. Ready, set, cleave: Proteases in action. Chem Biol 2013;20(2):137-138.

(31) Edgington LE, Verdoes M, Ortega A, Withana NP, Lee J, Syed S, et al. Functional imaging of legumain in cancer using a new quenched activity-based probe. J Am Chem Soc 2013;135(1):174-182.

(32) Rothberg JM, Bailey KM, Wojtkowiak JW, Ben-Nun Y, Bogyo M, Weber E, et al. Acid-mediated tumor proteolysis: Contribution of cysteine cathepsins. Neoplasia 2013;15(10):1125-1137.

(33) Mullins SR, Sameni M, Blum G, Bogyo M, Sloane BF, Moin K. Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: Role of cysteine cathepsins. Biol Chem 2012;393(12):1405-1416.

(34) Verdoes M, Edgington LE, Scheeren FA, Leyva M, Blum G, Weiskopf K, et al. A nonpeptidic cathepsin s activity-based probe for noninvasive optical imaging of tumor-associated macrophages. Chem Biol 2012;19(5):619-628.

(35) Cutter JL, Cohen NT, Wang J, Sloan AE, Cohen AR, Panneerselvam A, et al. Topical application of activity-based probes for visualization of brain tumor tissue. PLoS ONE 2012;7(3).

(36) Withana NP, Blum G, Sameni M, Slaney C, Anbalagan A, Olive MB, et al. Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res 2012;72(5):1199-1209.

(37) Ren G, Blum G, Verdoes M, Liu H, Syed S, Edgington LE, et al. Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe. PLoS ONE 2011;6(11).

(38) Tedelind S, Jordans S, Resemann H, Blum G, Bogyo M, Führer D, et al. Cathepsin B trafficking in thyroid carcinoma cells. Thyroid Res 2011;4(SUPPL. 1).

(39) Edgington LE, Berger AB, Blum G, Albrow VE, Paulick MG, Lineberry N, et al. Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes. Nat Med 2009;15(8):967-973.

(40) Blum G, Weimer RM, Edgington LE, Adams W, Bogyo M. Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity. PLoS ONE 2009;4(7).

(41) Chang S-, Kanasaki K, Gocheva V, Blum G, Harper J, Moses MA, et al. VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation. Cancer Res 2009;69(10):4537-4544.

(42) Cavallo-Medved D, Rudy D, Blum G, Bogyo M, Caglic D, Sloane BF. Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation. Exp Cell Res 2009;315(7):1234-1246.

(43) Yang Z, Fonović M, Verhelst SHL, Blum G, Bogyo M. Evaluation of α,β-unsaturated ketone-based probes for papain-family cysteine proteases. Bioorg Med Chem 2009;17(3):1071-1078.

(44) Blum G. Use of fluorescent imaging to investigate pathological protease activity. Curr Opin Drug Discov Dev 2008;11(5):708-716.

(45) Qvit N, Reuveni H, Gazal S, Zundelevich A, Blum G, Niv MY, et al. Synthesis of a novel macrocyclic library: Discovery of an IGF-1R inhibitor. J Comb Chem 2008;10(2):256-266.

(46) Blum G, Von Degenfeld G, Merchant MJ, Blau HM, Bogyo M. Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes. Nat Chem Biol 2007;3(10):668-677.

(47) Steiner L, Blum G, Friedmann Y, Levitzki A. ATP non-competitive IGF-1 receptor kinase inhibitors as lead anti-neoplastic and anti-papilloma agents. Eur J Pharmacol 2007;562(1-2):1-11.

(48) Sexton KB, Witte MD, Blum G, Bogyo M. Design of cell-permeable, fluorescent activity-based probes for the lysosomal cysteine protease asparaginyl endopeptidase (AEP)/legumain. Bioorg Med Chem Lett 2007;17(3):649-653.

(49) Yuan F, Verhelst SHL, Blum G, Coussens LM, Bogyo M. A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C. J Am Chem Soc 2006;128(17):5616-5617.

(50) Blum G, Mullins SR, Keren K, Fonovič M, Jedeszko C, Rice MJ, et al. Dynamic Imaging of Protease Activity With Fluorescently Quenched Activity-Based Probes. Nat Chem Biol 2005;1(4):203-209.

(51) Kato D, Boatright KM, Berger AB, Nazif T, Blum G, Ryan C, et al. Activity-Based Probes that Target Diverse Cysteine Protease Families. Nat Chem Biol 2005;1(1):33-38.

(52) Blum G, Gazit A, Levitzki A. Development of New Insulin-like Growth Factor-1 Receptor Kinase Inhibitors Using Catechol Mimics. J Biol Chem 2003;278(42):40442-40454.

(53) Blum G, Gazit A, Levitzki A. Substrate competitive inhibitors of IGF-1 receptor kinase. Biochemistry 2000;39(51):15705-15712.