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School of Pharmacy : Eyal Sara


 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Tetro N, Moushaev S, Shmuel M, Eyal S. Antiseizure medications and fetal nutrients: Effects on choline transporters in a human placental cell line. Epilepsia 2021.

(2) Ekstein D, Noyman I, Fahoum F, Herskovitz M, Under I, Zeev BB, et al. Treating epilepsy patients with investigational anti-COVID-19 Drugs: Recommendations by the Israeli chapter of the ILAE. Isr Med Assoc J 2020;22(11):665-672.

(3) Eyal S. How do the pharmacokinetics of drugs change in astronauts in space? Expert Opin Drug Metab Toxicol 2020;16(5):353-356.

(4) Eyal S, Derendorf H. One Giant Leap for Pharmacology. Pharm Res 2020;37(3).

(5) Eyal S, Derendorf H. Medications in Space: In Search of a Pharmacologist’s Guide to the Galaxy. Pharm Res 2019;36(10).

(6) Berman E, Eyal S. Drug Interactions in Space: a Cause for Concern? Pharm Res 2019;36(8).

(7) Tetro N, Imbar T, Wohl D, Eisenberg I, Yagel S, Shmuel M, et al. The effects of valproic acid on early pregnancy human placentas: Pilot ex vivo analysis in cultured placental villi. Epilepsia 2019;60(5):e47-e51.

(8) Han H, Eyal S, Portnoy E, Mann A, Shmuel M, Benifla M, et al. Monocytes as carriers of magnetic nanoparticles for tracking inflammation in the epileptic rat brain. Curr Drug Deliv 2019;16(7):637-644.

(9) Jabareen A, Leker RR, Eyal S, Ekstein D. Treatment with antiepileptic drugs in patients with stroke. A change in clinical practice may be required. J Neurol Sci 2018;395:4-7.

(10) Eyal S. The fever tree: From malaria to neurological diseases. Toxins 2018;10(12).

(11) Granit A, Tetro N, Shmuel M, Peretz T, Eyal S. Lacosamide at therapeutic concentrations induces histone hyperacetylation in vitro. Epilepsia Open 2018;3(4):535-539.

(12) Aboukaoud M, Israel S, Brautbar C, Eyal S. Genetic Basis of Delayed Hypersensitivity Reactions to Drugs in Jewish and Arab Populations. Pharm Res 2018;35(11).

(13) Brukner AM, Ben-Hur T, Honig A, Ekstein D, Eyal S. Effects of valproic acid on cerebral nutrient carriers' expression in the rat. Front Pharmacol 2018;9(SEP).

(14) Firer M, Bederovsky Y, Maggio N, Zaid H, Eyal S. Stevens-Johnson syndrome/toxic epidermal necrolysis in Jewish and Arab populations. Epilepsia 2018;59(7):1469-1470.

(15) Eyal S. Use of Therapeutics in Pregnancy and Lactation. Pharm Res 2018;35(5).

(16) Rubinchik-Stern M, Shmuel M, Bar J, Kovo M, Eyal S. Adverse placental effects of valproic acid: Studies in perfused human placentas. Epilepsia 2018;59(5):993-1003.

(17) Mann A, Portnoy E, Han H, Inbar D, Blatch D, Shmuel M, et al. Folate homeostasis in epileptic rats. Epilepsy Res 2018;142:64-72.

(18) Tetro N, Moushaev S, Rubinchik-Stern M, Eyal S. The Placental Barrier: the Gate and the Fate in Drug Distribution. Pharm Res 2018;35(4).

(19) Friedman-Levi Y, Larush L, Diana M, Marchegiani F, Marescaux J, Goder N, et al. Optimization of liposomal indocyanine green for imaging of the urinary pathways and a proof of concept in a pig model. Surg Endosc 2018;32(2):963-970.

(20) Berman E, Eyal S, Marom E. Trends in utilization of benzodiazepine and Z-drugs in Israel. Pharmacoepidemiol Drug Saf 2017;26(12):1555-1560.

(21) Andriyanov AV, Portnoy E, Koren E, Inesa S, Eyal S, Goldberg SN, et al. Therapeutic efficacy of combined PEGylated liposomal doxorubicin and radiofrequency ablation: Comparing single and combined therapy in young and old mice. J Control Release 2017;257:2-9.

(22) Han H, Mann A, Ekstein D, Eyal S. Breaking Bad: the Structure and Function of the Blood-Brain Barrier in Epilepsy. AAPS J 2017;19(4):973-988.

(23) Maggio N, Firer M, Zaid H, Bederovsky Y, Aboukaoud M, Gandelman-Marton R, et al. Causative Drugs of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Israel. J Clin Pharmacol 2017;57(7):823-829.

(24) Magdassi S, Bar-David S, Friedman-Levi Y, Zigmond E, Varol C, Lahat G, et al. Intraoperative Localization of Rectal Tumors Using Liposomal Indocyanine Green. Surg Innov 2017;24(2):139-144.

(25) Golenser J, Buchholz V, Bagheri A, Nasereddin A, Dzikowski R, Guo J, et al. Controlled release of artemisone for the treatment of experimental cerebral malaria. Parasites Vectors 2017;10(1).

(26) Semenenko I, Portnoy E, Aboukaoud M, Guzy S, Shmuel M, Itzhak G, et al. Evaluation of near infrared dyes as markers of P-glycoprotein activity in tumors. Front Pharmacol 2016;7(NOV).

(27) Mann A, Han H, Eyal S. Imaging transporters: Transforming diagnostic and therapeutic development. Clin Pharmacol Ther 2016:479-488.

(28) Israel S, Maggio N, Ekstein D, Zaid H, Firer M, Bederovsky Y, et al. Genetic risk factors for antiepileptic drug–induced hypersensitivity reactions in Israeli populations. Epilepsia 2016;57(10):e205-e209.

(29) Berman E, Marom E, Ekstein D, Blatt I, Eyal S. Utilization of antiepileptic drugs in Israel. Epilepsy Behav 2016;61:82-85.

(30) Rubinchik-Stern M, Shmuel M, Bar J, Eyal S, Kovo M. Maternal-fetal transfer of indocyanine green across the perfused human placenta. Reprod Toxicol 2016;62:100-105.

(31) Portnoy E, Polyak B, Inbar D, Kenan G, Rai A, Wehrli SL, et al. Tracking inflammation in the epileptic rat brain by bi-functional fluorescent and magnetic nanoparticles. Nanomed Nanotechnol Biol Med 2016;12(5):1335-1345.

(32) Meir M, Bishara A, Mann A, Udi S, Portnoy E, Shmuel M, et al. Effects of valproic acid on the placental barrier in the pregnant mouse: Optical imaging and transporter expression studies. Epilepsia 2016;57(6):e108-e112.

(33) Ryu RJ, Eyal S, Easterling TR, Caritis SN, Venkataraman R, Hankins G, et al. Pharmacokinetics of metoprolol during pregnancy and lactation. J Clin Pharmacol 2016;56(5):581-589.

(34) Lavi-Blau T, Ekstein D, Neufeld MY, Eyal S. Use of antiepileptic drugs during pregnancy and lactation: Type of information provided by searching Google. Epilepsy Behav 2016;55:113-119.

(35) Roth Y, Neufeld MY, Blatt I, Guy-Alfandary S, Rasaby S, Ekstein D, et al. An evaluation of pharmacist knowledge on treatment with antiepileptic drugs. Seizure 2016;34:60-65.

(36) Portnoy E, Vakruk N, Bishara A, Shmuel M, Magdassi S, Golenser J, et al. Indocyanine green liposomes for diagnosis and therapeutic monitoring of cerebral malaria. Theranostics 2016;6(2):167-176.

(37) Bishara A, Meir M, Portnoy E, Shmuel M, Eyal S. Near Infrared Imaging of Indocyanine Green Distribution in Pregnant Mice and Effects of Concomitant Medications. Mol Pharm 2015;12(9):3351-3357.

(38) Mann A, Semenenko I, Meir M, Eyal S. Molecular Imaging of Membrane Transporters’ Activity in Cancer: a Picture is Worth a Thousand Tubes. AAPS J 2015;17(4):788-801.

(39) Ekstein D, Tirosh M, Eyal Y, Eyal S. Drug interactions involving antiepileptic drugs: Assessment of the consistency among three drug compendia and FDA-approved labels. Epilepsy Behav 2015;44:218-224.

(40) Rubinchik-Stern M, Shmuel M, Eyal S. Antiepileptic drugs alter the expression of placental carriers: An in vitro study in a human placental cell line. Epilepsia 2015;56(7):1023-1032.

(41) Portnoy E, Nizri E, Golenser J, Shmuel M, Magdassi S, Eyal S. Imaging the urinary pathways in mice by liposomal indocyanine green. Nanomed Nanotechnol Biol Med 2015;11(5):1057-1064.

(42) Deo AK, Borson S, Link JM, Domino K, Eary JF, Ke B, et al. Activity of P-glycoprotein, a β-amyloid transporter at the blood-brain barrier, is compromised in patients with mild Alzheimer disease. J Nucl Med 2014;55(7):1106-1111.

(43) Eyal S, Rasaby S, Ekstein D. Concomitant therapy in people with epilepsy: Potential drug-drug interactions and patient awareness. Epilepsy Behav 2014;31:369-376.

(44) Abdelrahman I, Shmuel M, Eyal S. Interactions of ABCG2 (BCRP) with epidermal growth factor receptor kinase inhibitors developed for molecular imaging. Front Pharmacol 2014;5(NOV).

(45) Ryu RJ, Eyal S, Kaplan HG, Akbarzadeh A, Hays K, Puhl K, et al. Pharmacokinetics of doxorubicin in pregnant women. Cancer Chemother Pharmacol 2014;73(4):789-797.

(46) Stiebel-Kalish H, Eyal S, Steiner I. The role of aquaporin-1 in idiopathic and drug-induced intracranial hypertension. Med Hypotheses 2013;81(6):1059-1062.

(47) Ke AB, Eyal S, Chung FS, Link JM, Mankoff DA, Muzi M, et al. Modeling cyclosporine a inhibition of the distribution of a P-glycoprotein PET ligand, 11-Cverapamil, into the maternal brain and fetal liver of the pregnant nonhuman primate: Impact of tissue blood flow and site of inhibition. J Nucl Med 2013;54(3):437-446.

(48) Portnoy E, Gurina M, Magdassi S, Eyal S. Evaluation of the near infrared compound indocyanine green as a probe substrate of P-glycoprotein. Mol Pharm 2012;9(12):3595-3601.

(49) Rubinchik-Stern M, Eyal S. Drug interactions at the human placenta: What is the evidence? Front Pharmacol 2012;3 JUL.

(50) Unadkat JD, Ke B, Eyal S. The impact of the BBB on the pharmacokinetics of drugs: Investigations by PET. Trends on the Role of PET in Drug Development; 2012. p. 575-614.

(51) Eyal S, Kim JD, Anderson GD, Buchanan ML, Brateng DA, Carr D, et al. Atenolol pharmacokinetics and excretion in breast milk during the first 6 to 8 months postpartum. J Clin Pharmacol 2010;50(11):1301-1309.

(52) Claessens AJ, Risler LJ, Eyal S, Shen DD, Easterling TR, Hebert MF. CYP2D6 mediates 4-hydroxylation of clonidine in vitro: Implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos 2010;38(9):1393-1396.

(53) Eyal S, Ke B, Muzi M, Link JM, Mankoff DA, Collier AC, et al. Regional P-glycoprotein activity and inhibition at the human blood-brain barrier as imaged by positron emission tomography. Clin Pharmacol Ther 2010;87(5):579-585.

(54) Eyal S, Easterling TR, Carr D, Umans JG, Miodovnik M, Hankins GDV, et al. Pharmacokinetics of metformin during pregnancy. Drug Metab Dispos 2010;38(5):833-840.

(55) Chung FS, Eyal S, Muzi M, Link JM, Mankoff DA, Kaddoumi A, et al. Positron emission tomography imaging of tissue P-glycoprotein activity during pregnancy in the non-human primate. Br J Pharmacol 2010;159(2):394-404.

(56) Swed A, Eyal S, Madar I, Zohar-Kontante H, Weiss L, Hoffman A. The role of P-glycoprotein in intestinal transport versus the BBB transport of tetraphenylphosphonium. Mol Pharm 2009;6(6):1883-1890.

(57) Eyal S, Hsiao P, Unadkat JD. Drug interactions at the blood-brain barrier: Fact or fantasy? Pharmacol Ther 2009;123(1):80-104.

(58) Eyal S, Chung FS, Muzi M, Link JM, Mankoff DA, Kaddoumi A, et al. Simultaneous PET imaging of P-glycoprotein inhibition in multiple tissues in the pregnant nonhuman primate. J Nucl Med 2009;50(5):798-806.

(59) Unadkat JD, Chung F, Sasongko L, Whittington D, Eyal S, Mankoff D, et al. Rapid solid-phase extraction method to quantify [11C]-verapamil, and its [11C]-metabolites, in human and macaque plasma. Nucl Med Biol 2008;35(8):911-917.

(60) Shimshoni JA, Dalton EC, Jenkins A, Eyal S, Ewan K, Williams RSB, et al. The effects of central nervous system-active valproic acid constitutional isomers, cyclopropyl analogs, and amide derivatives on neuronal growth cone behavior. Mol Pharmacol 2007;71(3):884-892.

(61) Eyal S, Lamb JG, Smith-Yockman M, Yagen B, Fibach E, Altschuler Y, et al. The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver. Br J Pharmacol 2006;149(3):250-260.

(62) Eyal S, Yagen B, Shimshoni J, Bialer M. Histone deacetylases inhibition and tumor cells cytotoxicity by CNS-active VPA constitutional isomers and derivatives. Biochem Pharmacol 2005;69(10):1501-1508.

(63) Eyal S, Yagen B, Sobol E, Altschuler Y, Shmuel M, Bialer M. The activity of antiepileptic drugs as histone deacetylase inhibitors. Epilepsia 2004;45(7):737-744.

(64) Hoffman A, Stepensky D, Lavy E, Eyal S, Klausner E, Friedman M. Pharmacokinetic and pharmacodynamic aspects of gastroretentive dosage forms. Int J Pharm 2004;277(1-2):141-153.

(65) Klausner EA, Eyal S, Lavy E, Friedman M, Hoffman A. Novel levodopa gastroretentive dosage form: In-vivo evaluation in dogs. J Control Release 2003;88(1):117-126.

(66) Zaidenstein R, Eyal S, Efrati S, Akivison L, Michowitz MK, Nagornov V, et al. Adverse drug events in hospitalized patients treated with cardiovascular drugs and anticoagulants. Pharmacoepidemiol Drug Saf 2002;11(3):235-238.

(67) Zaidenstein R, Golik A, Eyal S, Efrati S, Akivision L, Koren M, et al. Adverse drug events in patients treated with cardiovascular drugs and anticoa gulants. Clin Pharmacol Ther 2001;69(2).

(68) Eyal S, Weizman A, Toren P, Dor Y, Mester R, Rehavi M. Chronic GnRH agonist administration down-regulates platelet serotonin transporter in women undergoing assisted reproductive treatment. PSYCHOPHARMACOLOGY 1996;125(2):141-145.