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School of Pharmacy : Kohen Ron


 Last updated December 2021 - School of Pharmacy

List of Publications

(1) Pinchuk I, Kohen R, Stuetz W, Weber D, Franceschi C, Capri M, et al. Do low molecular weight antioxidants contribute to the Protection against oxidative damage? The interrelation between oxidative stress and low molecular weight antioxidants based on data from the MARK-AGE study. Arch Biochem Biophys 2021;713.

(2) Ron-Doitch S, Soroka Y, Frusic-Zlotkin M, Barasch D, Steinberg D, Kohen R. Saturated and aromatic aldehydes originating from skin and cutaneous bacteria activate the Nrf2-keap1 pathway in human keratinocytes. Exp Dermatol 2021;30(10):1381-1387.

(3) Ron-Doitch S, Frušić-Zlotkin M, Soroka Y, Duanis-Assaf D, Amar D, Kohen R, et al. EDNA-mediated cutaneous protection against UVB damage conferred by staphylococcal epidermal colonization. Microorg 2021;9(4).

(4) Ron-Doitch S, Kohen R. The cutaneous physiological redox: Essential to maintain but difficult to define. Antioxidants 2020;9(10):1-12.

(5) Brandwein M, Katz I, Katz A, Kohen R. Beyond the gut: Skin microbiome compositional changes are associated with BMI. Hum Microbiome J 2019;13.

(6) Saidian M, Lakey JRT, Ponticorvo A, Rowland R, Baldado M, Williams J, et al. Characterisation of impaired wound healing in a preclinical model of induced diabetes using wide-field imaging and conventional immunohistochemistry assays. Int Wound J 2019;16(1):144-152.

(7) Lenchner I, Segev G, Ari TB, Kohen R, Sirota R, Bruchim Y. Serial evaluation of serum total reduction power potential by cyclic voltammetry in 30 dogs with gastric dilatation and volvulus- a randomised, controlled (lidocaine vs placebo), clinical trial. Res Vet Sci 2018;117:92-96.

(8) Beiser T, Numa R, Kohen R, Yaka R. Chronic treatment with Tempol during acquisition or withdrawal from CPP abolishes the expression of cocaine reward and diminishes oxidative damage. Sci Rep 2017;7(1).

(9) Sirota R, Gibson D, Kohen R. The timing of caffeic acid treatment with cisplatin determines sensitization or resistance of ovarian carcinoma cell lines. Redox Biol 2017;11:170-175.

(10) Ben-Yehuda Greenwald M, Frušić-Zlotkin M, Soroka Y, Ben-Sasson S, Bianco-Peled H, Kohen R. A novel role of topical iodine in skin: Activation of the Nrf2 pathway. Free Radic Biol Med 2017;104:238-248.

(11) Ben Yehuda Greenwald M, Frušić-Zlotkin M, Soroka Y, Ben Sasson S, Bitton R, Bianco-Peled H, et al. Curcumin Protects Skin against UVB-Induced Cytotoxicity via the Keap1-Nrf2 Pathway: The Use of a Microemulsion Delivery System. Oxidative Med Cell Longevity 2017;2017.

(12) Ginsburg I, Koren E, Varani J, Kohen R. Nuclear histones: major virulence factors or just additional early sepsis markers? A comment. Inflammopharmacology 2016;24(5):287-289.

(13) Goldstein A, Soroka Y, Frušić-Zlotkin M, Lewis A, Kohen R. The bright side of plasmonic gold nanoparticles; Activation of Nrf2, the cellular protective pathway. Nanoscale 2016;8(22):11748-11759.

(14) Greenwald MB-, Ben-Sasson S, Bianco-Peled H, Kohen R. Skin redox balance maintenance: The need for an Nrf2-activator delivery system. Cosmetics 2016;3(1).

(15) Ben Yehuda Greenwald M, Frušić-Zlotkin M, Soroka Y, Sasson SB, Bianco-Peled H, Bitton R, et al. Nitroxide delivery system for Nrf2 activation and skin protection. Eur J Pharm Biopharm 2015;94:123-134.

(16) Sirota R, Gibson D, Kohen R. The role of the catecholic and the electrophilic moieties of caffeic acid in Nrf2/Keap1 pathway activation in ovarian carcinoma cell lines. Redox Biol 2015;4:48-59.

(17) Goldstein A, Soroka Y, Frušić-Zlotkin M, Popov I, Kohen R. High resolution SEM imaging of gold nanoparticles in cells and tissues. J Microsc 2014;256(3):237-247.

(18) Ben Yehuda Greenwald M, Anzi S, Ben Sasson S, Bianco-Peled H, Kohen R. Can nitroxides evoke the Keap1-Nrf2-ARE pathway in skin? Free Radic Biol Med 2014;77:258-269.

(19) Portugal-Cohen M, Kohen R. Non-invasive evaluation of skin cytokines secretion: An innovative complementary method for monitoring skin disorders. Methods 2013;61(1):63-68.

(20) Ginsburg I, Kohen R, Shalish M, Varon D, Shai E, Koren E. The Oxidant-Scavenging Abilities in the Oral Cavity May Be Regulated by a Collaboration among Antioxidants in Saliva, Microorganisms, Blood Cells and Polyphenols: A Chemiluminescence-Based Study. PLoS ONE 2013;8(5).

(21) Sirota R, Gorelik S, Harris R, Kohen R, Kanner J. Coffee polyphenols protect human plasma from postprandial carbonyl modifications. Mol Nutr Food Res 2013;57(5):916-919.

(22) Rosenzweig O, Lavy E, Gati I, Kohen R, Friedman M. Development and in vitro characterization of floating sustained-release drug delivery systems of polyphenols. Drug Deliv 2013;20(3-4):180-189.

(23) Ginsburg I, Kohen R, Koren E. Saliva: A 'solubilizer' of lipophilic antioxidant polyphenols. Oral Dis 2013;19(3):321-322.

(24) Gorelik S, Kanner J, Schurr D, Kohen R. A rational approach to prevent postprandial modification of LDL by dietary polyphenols. J Funct Foods 2013;5(1):163-169.

(25) Gorelik S, Kanner J, Kohen R. Additional ways to diminish the deleterious effects of red meat. Arch Intern Med 2012;172(18):1424-1425.

(26) Ginsburg I, Koren E, Shalish M, Kanner J, Kohen R. Saliva increases the availability of lipophilic polyphenols as antioxidants and enhances their retention in the oral cavity. Arch Oral Biol 2012;57(10):1327-1334.

(27) Kanner J, Gorelik S, Roman S, Kohen R. Protection by polyphenols of postprandial human plasma and low-density lipoprotein modification: The stomach as a bioreactor. J Agric Food Chem 2012;60(36):8790-8796.

(28) Portugal-Cohen M, Horev L, Ruffer C, Schlippe G, Voss W, Ma'or Z, et al. Non-invasive skin biomarkers quantification of psoriasis and atopic dermatitis: Cytokines, antioxidants and psoriatic skin auto-fluorescence. Biomed Pharmacother 2012;66(4):293-299.

(29) Erlank H, Elmann A, Kohen R, Kanner J. Polyphenols activate Nrf2 in astrocytes via H 2O 2, semiquinones, and quinones. Free Radic Biol Med 2011;51(12):2319-2327.

(30) Portugal-Cohen M, Soroka Y, Frušić-Zlotkin M, Verkhovsky L, Brégégère FM, Neuman R, et al. Skin organ culture as a model to study oxidative stress, inflammation and structural alterations associated with UVB-induced photodamage. Exp Dermatol 2011;20(9):749-755.

(31) Portugal-Cohen M, Oron M, Ma'or Z, Boaz M, Shtendik L, Biro A, et al. Noninvasive skin measurements to monitor chronic renal failure pathogenesis. Biomed Pharmacother 2011;65(4):280-285.

(32) Ginsburg I, Kohen R, Koren E. Quantifying oxidant-scavenging ability of blood. New Engl J Med 2011;364(9):883-885.

(33) Ginsburg I, Kohen R, Koren E. Microbial and host cells acquire enhanced oxidant-scavenging abilities by binding polyphenols. Arch Biochem Biophys 2011;506(1):12-23.

(34) Numa R, Baron M, Kohen R, Yaka R. Tempol attenuates cocaine-induced death of PC12 cells through decreased oxidative damage. Eur J Pharmacol 2011;650(1):157-162.

(35) Koren E, Kohen R, Ginsburg I. Polyphenols enhance total oxidant-scavenging capacities of human blood by binding to red blood cells. Exp Biol Med 2010;235(6):689-699.

(36) Portugal-Cohen M, Numa R, Yaka R, Kohen R. Cocaine induces oxidative damage to skin via xanthine oxidase and nitric oxide synthase. J Dermatol Sci 2010;58(2):105-112.

(37) Noyhouzer T, Kohen R, Mandler D. A new approach for measuring the redox state and redox capacity in milk. Anal Methods 2009;1(2):93-99.

(38) Boaz M, Shtendik L, Oron M, Portugal-Cohen M, Kohen R, Biro A, et al. A randomized controlled clinical trial comparing the efficacy of dead sea mineral-enriched body lotion versus two types of placebo in the treatment of cutaneous dryness, itching, peeling and tightness in hemodialysis patients (EDIT). Nephron Clin Pract 2009;113(3):c169-c176.

(39) Koren E, Kohen R, Lipkin J, Klar A, Hershkovitz E, Ginsburg I. Total oxidant-scavenging capacities of plasma from glycogen storage disease type Ia patients as measured by cyclic voltammetry, FRAP and luminescence techniques. J Inherit Metab Dis 2009;32(5):651-659.

(40) Volk J, Gorelik S, Granit R, Kohen R, Kanner J. The dual function of nitrite under stomach conditions is modulated by reducing compounds. Free Radic Biol Med 2009;47(5):496-502.

(41) Portugal-Cohen M, Soroka Y, Ma'or Z, Oron M, Zioni T, Brégégère FM, et al. Protective effects of a cream containing Dead Sea minerals against UVB-induced stress in human skin. Exp Dermatol 2009;18(9):781-788.

(42) Koren E, Kohen R, Ovadia H, Ginsburg I. Bacteria coated by polyphenols acquire potent oxidant-scavenging capacities. Exp Biol Med 2009;234(8):940-951.

(43) Portugal-Cohen M, Kohen R. Exposure of human keratinocytes to ischemia, hyperglycemia and their combination induces oxidative stress via the enzymes inducible nitric oxide synthase and xanthine oxidase. J Dermatol Sci 2009;55(2):82-90.

(44) Arien-Zakay H, Lecht S, Bercu MM, Tabakman R, Kohen R, Galski H, et al. Neuroprotection by cord blood neural progenitors involves antioxidants, neurotrophic and angiogenic factors. Exp Neurol 2009;216(1):83-94.

(45) Portugal M, Kohen R. Peroxynitrite: A key molecule in skin tissue response to different types of stress. Oxidants in Biology: A Question of Balance; 2008. p. 19-36.

(46) Ryu S, Ornoy A, Samuni A, Zangen S, Kohen R. Oxidative stress in Cohen diabetic rat model by high-sucrose, low-copper diet: inducing pancreatic damage and diabetes. Metab Clin Exp 2008;57(9):1253-1261.

(47) Numa R, Kohen R, Poltyrev T, Yaka R. Tempol diminishes cocaine-induced oxidative damage and attenuates the development and expression of behavioral sensitization. Neuroscience 2008;155(3):649-658.

(48) Gorelik S, Ligumsky M, Kohen R, Kanner J. The stomach as a "bioreactor": When red meat meets red wine. J Agric Food Chem 2008;56(13):5002-5007.

(49) Koren E, Zverev I, Ginsburg I, Kohen R. Supplementation with antioxidants fails to increase the total antioxidant capacity of several cell lines in culture. Biomed Pharmacother 2008;62(3):179-188.

(50) Gorelik S, Ligumsky M, Kohen R, Kanner J. A novel function of red wine polyphenols in humans: Prevention of absorption of cytotoxic lipid peroxidation products. FASEB J 2008;22(1):41-46.

(51) Ryu S, Kohen R, Samuni A, Ornoy A. Nitroxide radicals protect cultured rat embryos and yolk sacs from diabetic-induced damage. Birth Defects Res Part A Clin Mol Teratol 2007;79(8):604-611.

(52) Portugal M, Barak V, Ginsburg I, Kohen R. Interplay among oxidants, antioxidants, and cytokines in skin disorders: Present status and future considerations. Biomed Pharmacother 2007;61(7):412-422.

(53) Gorelik S, Kohen R, Ligumsky M, Kanner J. Saliva plays a dual role in oxidation process in stomach medium. Arch Biochem Biophys 2007;458(2):236-243.

(54) Wasserman V, Kizelsztein P, Garbuzenko O, Kohen R, Ovadia H, Tabakman R, et al. The antioxidant tempamine: In vitro antitumor and neuroprotective effects and optimization of liposomal encapsulation and release. Langmuir 2007;23(4):1937-1947.

(55) Tur'yn YI, Mata F, Moyano J, Gorenbein P, Kohen R. Mechanism of the electroreduction of Ni (II) ions on mercury electrodes catalyzed by pyridine and its derivatives: Nicotinamide, N,N-diethylnicotinamide and nicotine: Concept of parallel heterogeneous catalytic reactions. J Solid State Electrochem 2006;11(1):10-20.

(56) Hochberg M, Kohen R, Enk CD. Role of antioxidants in prevention of pyrimidine dimer formation in UVB irradiated human HaCaT keratinocytes. Biomed Pharmacother 2006;60(5):233-237.

(57) Yavlovich A, Kohen R, Ginsburg I, Rottem S. The reducing antioxidant capacity of Mycoplasma fermentans. FEMS Microbiol Lett 2006;259(2):195-200.

(58) Panikashvili D, Shein NA, Mechoulam R, Trembovler V, Kohen R, Alexandrovich A, et al. The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines. Neurobiol Dis 2006;22(2):257-264.

(59) Katzenellenbogen M, Pappo O, Barash H, Klopstock N, Mizrahi L, Olam D, et al. Multiple adaptive mechanisms to chronic liver disease revealed at early stages of liver carcinogenesis in the Mdr2-knockout mice. Cancer Res 2006;66(8):4001-4010.

(60) Beni SM, Tsenter J, Alexandrovich AG, Galron-Krool N, Barzilai A, Kohen R, et al. CuZn-SOD deficiency, rather than overexpression, is associated with enhanced recovery and attenuated activation of NF-κB after brain trauma in mice. J Cereb Blood Flow Metab 2006;26(4):478-490.

(61) Moor E, Shohami E, Kanevsky E, Grigoriadis N, Symeonidou C, Kohen R. Impairment of the ability of the injured aged brain in elevating urate and ascorbate. Exp Gerontol 2006;41(3):303-311.

(62) Ligumsky M, Klar A, Siguencia J, Arnon R, Gati I, Kohen R. Changes in reducing power profile of gastric juice in patients with active duodenal ulcer. Biomed Pharmacother 2005;59(7):345-350.

(63) Gorelik S, Lapidot T, Shaham I, Granit R, Ligumsky M, Kohen R, et al. Lipid peroxidation and coupled vitamin oxidation in simulated and human gastric fluid inhibited by dietary polyphenols: Health implications. J Agric Food Chem 2005;53(9):3397-3402.

(64) Israeli A, Patt M, Oron M, Samuni A, Kohen R, Goldstein S. Kinetics and mechanism of the comproportionation reaction between oxoammonium cation and hydroxylamine derived from cyclic nitroxides. Free Radic Biol Med 2005;38(3):317-324.

(65) Miskin R, Tirosh O, Pardo M, Zusman I, Schwartz B, Yahav S, et al. αMUPA mice: A transgenic model for longevity induced by caloric restriction. Mech Ageing Dev 2005;126(2):255-261.

(66) Glantz L, Avramovich A, Trembovler V, Gurvitz V, Kohen R, Eidelman LA, et al. Ischemic preconditioning increases antioxidants in the brain and peripheral organs after cerebral ischemia. Exp Neurol 2005;192(1):117-124.

(67) Ginsburg I, Sadovnic M, Oron M, Kohen R. Novel chemiluminescence-inducing cocktails, part II: Measurement of the anti-oxidant capacity of vitamins, thiols, body fluids, alcoholic beverages and edible oils. Inflammopharmacology 2004;12(4):305-320.

(68) Ginsburg I, Sadovnic M, Oron M, Kohen R. Novel chemiluminescence-inducing cocktails, part I: The role in light emission of combinations of luminal with SIN-1, selenite, albumin, glucose oxidase and Co2+. Inflammopharmacology 2004;12(4):289-303.

(69) Israeli E, Berenshtein E, Wengrower D, Aptekar L, Kohen R, Zajicek G, et al. Prophylactic administration of topical glutamine enhances the capability of the rat colon to resist inflammatory damage. Dig Dis Sci 2004;49(10):1705-1712.

(70) Tur'yan YI, Gorenbein P, Kohen R. Theory of the oxygen voltammetric electroreduction process in the presence of an antioxidant for estimation of antioxidant activity. J Electroanal Chem 2004;571(2):183-188.

(71) Nyska A, Haseman JK, Kohen R, Maronpot RR. Association of Liver Hemangiosarcoma and Secondary Iron Overload in B6C3F1 Mice - The National Toxicology Program Experience. Toxicol Pathol 2004;32(2):222-228.

(72) Tabakman R, Jiang H, Levine RA, Kohen R, Lazarovici P. Apoptotic Characteristics of Cell Death and the Neuroprotective Effect of Homocarnosine on Pheochromocytoma PC12 Cells Exposed to Ischemia. J Neurosci Res 2004;75(4):499-507.

(73) Beni SM, Kohen R, Reiter RJ, Tan DX, Shohami E. Melatonin-induced neuroprotection after closed head injury is associated with increased brain antioxidants and attenuated late-phase activation of NF-kappaB and AP-1. FASEB J 2004;18(1):149-151.

(74) Granot E, Kohen R. Oxidative stress in abetalipoproteinemia patients receiving long-term vitamin E and vitamin A supplementation. Am J Clin Nutr 2004;79(2):226-230.

(75) Granot E, Kohen R. Oxidative stress in childhood - In health and disease states. Clin Nutr 2004;23(1):3-11.

(76) Kohen R, Oron M, Zelkowicz A, Kanevsky E, Farfouri S, Wormser U. Low molecular weight antioxidants released from the skin's epidermal layers: An age dependent phenomenon in the rat. Exp Gerontol 2004;39(1):67-72.

(77) Butera D, Tesoriere L, Di Gaudio F, Bongiorno A, Allegra M, Pintaudi AM, et al. Antioxidant activities of sicilian prickly pear (Opuntia ficus indica) fruit extracts and reducing properties of its betalains: Betanin and indicaxanthin. J Agric Food Chem 2002;50(23):6895-6901.

(78) Kohen R, Nyska A. Oxidation of biological systems: Oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol Pathol 2002;30(6):620-650.

(79) Tabakman R, Lazarovici P, Kohen R. Neuroprotective effects of carnosine and homocarnosine on pheochromocytoma PC12 cells exposed to ischemia. J Neurosci Res 2002;68(4):463-469.

(80) Ginsburg I, Sadovnic M, Yedgar S, Kohen R, Hrbac J. Hemolysis of human erythrocytes by hypochlorous acid is modulated by amino acids, antioxidants, oxidants, membrane-perforating agents and by divalent metals. Free Radic Res 2002;36(6):607-619.

(81) Tan DX, Reiter RJ, Manchester LC, Yan MT, El-Sawi M, Sainz RM, et al. Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger. Curr Top Med Chem 2002;2(2):181-197.

(82) Nitzan DW, Goldfarb A, Gati I, Kohen R. Changes in the reducing power of synovial fluid from temporomandibular joints with “anchored disc phenomenon”. J Oral Maxillofac Surg 2002;60(7):735-740.

(83) Granot E, Elinav H, Kohen R. Markers of oxidative stress in cyclosporine-treated and tacrolimus-treated children after liver transplantation. Liver Transplant 2002;8(5):469-475.

(84) Moor E, Kohen R, Reiter RJ, Shohami E. Closed head injury increases extracellular levels of antioxidants in rat hippocampus in vivo: An adaptive mechanism? Neurosci Lett 2001;316(3):169-172.

(85) Elinav H, Kohen R, Granot E. Plasma oxidizability and plasma carbonyls, markers of oxidative stress, in liver transplant patients. Transplant Proc 2001;33(6):2918-2919.

(86) Zaken V, Kohen R, Ornoy A. Geometric morphometrics of corpus callosum and subcortical structures in the fetal-alcohol-affected brain. Teratology 2001;64(1):4-32.

(87) Tan DX, Manchester LC, Burkhardt S, Sainz RM, Mayo JC, Kohen R, et al. N1-acetyl-N2-formyl-5-methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant. FASEB J 2001;15(12):2294-2296.

(88) Schlosser-Silverman E, Elgrably-Weiss M, Rosenshine I, Kohen R, Altuvia S. Characterization of Escherichia coli DNA lesions generated within J774 macrophages. J Bacteriol 2000;182(18):5225-5230.

(89) Kohen R, Gati I. Skin low molecular weight antioxidants and their role in aging and in oxidative stress. Toxicology 2000;148(2-3):149-157.

(90) Blau S, Kohen R, Bass P, Rubinstein A. Relation between colonic inflammation severity and total low-molecular- weight antioxidant profiles in experimental colitis. Dig Dis Sci 2000;45(6):1180-1187.

(91) Kohen R, Vellaichamy E, Hrbac J, Gati I, Tirosh O. Quantification of the overall reactive oxygen species scavenging capacity of biological fluids and tissues. Free Radic Biol Med 2000;28(6):871-879.

(92) Dubnov G, Kohen R, Berry EM. Diet restriction in mice causes differential tissue responses in total reducing power and antioxidant compounds. Eur J Nutr 2000;39(1):18-30.

(93) Rubinstein A, Blau S, Bass P, Kohen R. The effect of adhesive antioxidant enzymes on experimental colitis in the rat. ACS Symp Ser 2000;752:78-89.

(94) Zaken V, Kohen R, Ornoy A. The development of antioxidant defense mechanism in young rat embryos in vivo and in vitro. Early Pregnancy 2000;4(2):110-123.

(95) Elangovan V, Shohami E, Gati I, Kohen R. Increased hepatic lipid soluble antioxidant capacity as compared to other organs of streptozotocin-induced diabetic rats: A cyclic voltammetry study. Free Radic Res 2000;32(2):125-134.

(96) Hrbac J, Kohen R. Biological redox activity: Its importance, methods for its quantification and implication for health and disease. Drug Dev Res 2000;50(3-4):516-527.

(97) Blau S, Kohen R, Bass P, Rubinstein A. The effect of local attachment of cationized antioxidant enzymes on experimental colitis in the rat. Pharm Res 2000;17(9):1077-1084.

(98) Elangovan V, Kohen R, Shohami E. Neurological recovery from closed head injury is impaired in diabetic rats. J Neurotrauma 2000;17(11):1013-1027.

(99) Ornoy A, Zaken V, Kohen R. Role of reactive oxygen species (ROS) in the diabetes-induced anomalies in rat embryos in vitro: Reduction in antioxidant enzymes and low-molecular-weight antioxidants (LMWA) may be the causative factor for increased anomalies. Teratology 1999;60(6):376-386.

(100) Ginsburg I, Sadovnic M, Varani J, Tirosh O, Kohen R. Hemolysis of human red blood cells induced by the combination of diethyldithiocarbamate (DDC) and divalent metals: Modulation by anaerobiosis, certain antioxidants and oxidants. Free Radic Res 1999;31(2):79-91.

(101) Blau S, Rubinstein A, Bass P, Singaram C, Kohen R. Differences in the reducing power along the rat GI tract: Lower antioxidant capacity of the colon. Mol Cell Biochem 1999;194(1-2):185-191.

(102) Lomnitski L, Chapman S, Hochman A, Kohen R, Shohami E, Chen Y, et al. Antioxidant mechanisms in apolipoprotein E deficient mice prior to and following closed head injury. Biochim Biophys Acta Mol Basis Dis 1999;1453(3):359-368.

(103) Effect of adhesive antioxidant enzymes on experimental colitis in the rat. American Chemical Society, Polymer Preprints, Division of Polymer Chemistry; 1999.

(104) Tirosh O, Katzhendler J, Barenholz Y, Kohen R. Low-Density Lipoprotein Oxidation and Its Prevention by Amidothionophosphate Antioxidants. Antioxid Redox Signal 1999;1(3):325-338.

(105) Kohen R. Skin antioxidants: Their role in aging and in oxidative stress - New approaches for their evaluation. Biomed Pharmacother 1999;53(4):181-192.

(106) Shohami E, Gati I, Beit-Yannai E, Trembovler V, Kohen R. Closed head injury in the rat induces whole body oxidative stress: Overall reducing antioxidant profile. J Neurotrauma 1999;16(5):365-376.

(107) Berry EM, Kohen R. Is the biological antioxidant system integrated and regulated? Med Hypotheses 1999;53(5):397-401.

(108) Kohen R, Fanberstein D, Zelkowicz A, Tirosh O, Farfouri S. Noninvasive in vivo evaluation of skin antioxidant activity and oxidation status. Methods Enzymol 1999;300:428-437.

(109) Kohen R, Beit-Yannai E, Berry EM, Tirosh O. Overall low molecular weight antioxidant activity of biological fluids and tissues by cyclic voltammetry. Methods Enzymol 1999;300:285-296.

(110) Tirosh O, Katzhendler Y, Barenholz Y, Kohen R. Antioxidant activity of amidothionophosphates. Methods Enzymol 1999;299:293-300.

(111) Granot E, Shemesh P, Rivkin L, Kohen R. Plasma and low-density lipoprotein lipid peroxidation in cyclosporine A- treated children after liver transplant. Transplant Proc 1998;30(8):4057-4059.

(112) Beit-Yannai E, Trembovler V, Horowitz M, Lazarovici P, Kohen R, Shohami E. Neuroprotection against oxidative stress by serum from heat acclimated rats. Neurosci Lett 1998;254(2):89-92.

(113) Wormser U, Brodsky B, Moor EV, Eldad A, Gal R, Nyska A, et al. Skin surface proteolytic activity: Partial characterization and identification. Adv Exp Med Biol 1998;436:207-212.

(114) Blau S, Kohen R, Bass P, Rubinstein A. Local treatment with cationized antioxidant enzymes reduces experimental colitis in the rat. Proc Control Release Soc 1998(25):8-9.

(115) Wormser U, Kohen R, Moor EV, Eldad A, Gal R, Nyska A, et al. Noninvasive procedure for in situ determination of skin surface aspartic proteinase activity in animals; Implications for human skin. Arch Dermatol Res 1997;289(12):686-691.

(116) Tirosh O, Kohen R, Katzhendler J, Alon A, Barenholz Y. Oxidative stress effect on the integrity of lipid bilayers is modulated by cholesterol level of bilayers. Chem Phys Lipids 1997;87(1):17-22.

(117) Tur'yan YI, Kohen R. Mechanism of Dehydro-L-ascorbic Acid Reduction at Mercury Dropping Electrode. Croat Chem Acta 1997;70(2):599-615.

(118) Lomnitski L, Kohen R, Chen Y, Shohami E, Trembovler V, Vogel T, et al. Reduced levels of antioxidants in brains of apolipoprotein E-deficient mice following closed head injury. Pharmacol Biochem Behav 1997;56(4):669-673.

(119) Kohen R, Fanberstein D, Tirosh O. Reducing equivalents in the aging process. Arch Gerontol Geriatr 1997;24(2):103-123.

(120) Chevion S, Berry EM, Kitrossky N, Kohen R. Evaluation of plasma low molecular weight antioxidant capacity by cyclic voltammetry. Free Radic Biol Med 1997;22(3):411-421.

(121) Beit-Yannai E, Kohen R, Horowitz M, Trembovler V, Shohami E. Changes of biological reducing activity in rat brain following closed head injury: A cyclic voltammetry study in normal and heat-acclimated rats. J Cereb Blood Flow Metab 1997;17(3):273-279.

(122) Shohami E, Beit-Yannai E, Horowitz M, Kohen R. Oxidative stress in closed-head injury: Brain antioxidant capacity as an indicator of functional outcome. J Cereb Blood Flow Metab 1997;17(10):1007-1019.

(123) Tirosh O, Kohen R, Katzhendler J, Gorodetsky R, Barenholz Y. Novel synthetic phospholipid protects lipid bilayers against oxidation damage: Role of hydration layer and bound water. J Chem Soc Perkin Trans 2 1997(2):383-389.

(124) Cohen O, Kohen R, Lavon E, Abramsky O, Steiner I. Serum Cu/Zn superoxide dismutase activity is reduced in sporadic amyotrophic lateral sclerosis patients. J Neurol Sci 1996;143(1-2):118-120.

(125) Ornoy A, Kimyagarov D, Yaffee P, Abir R, Raz I, Kohen R. Role of reactive oxygen species in diabetes-induced embryotoxicity: Studies on pre-implantation mouse embryos cultured in serum from diabetic pregnant women. Isr J Med Sci 1996;32(11):1066-1073.

(126) Tirosh O, Katzhendler Y, Barenholz Y, Ginsburg I, Kohen R. Antioxidant properties of amidothionophosphates: Novel antioxidant molecules. Free Radic Biol Med 1996;20(3):421-432.

(127) Ezra R, Benita S, Ginsburg I, Kohen R. Prevention of oxidative damage in fibroblast cell cultures and rat skin by positively-charged submicron emulsion of α-tocopherol. Eur J Pharm Biopharm 1996;42(4):291-298.

(128) Eshhar N, Striem S, Kohen R, Tirosh O, Biegon A. Neuroprotective and antioxidant activities of HU-211, a novel NMDA receptor antagonist. Eur J Pharmacol 1995;283(1-3):19-29.

(129) Ginsburg I, Kohen R. Synergistic effects among oxidants, membrane-damaging agents, fatty acids, proteinases, and xenobiotics: Killing of epithelial cells and release of arachidonic acid. Inflammation 1995;19(1):101-118.

(130) Tur'yan YI, Kohen R. Formal redox potentials of the dehydro-l-ascorbic acid/l-ascorbic acid system. J Electroanal Chem 1995;380(1-2):273-277.

(131) Ginsburg I, Kohen R. Invited review: Cell damage in inflammatory and infectious sites might involve a coordinated "Cross-talk" among oxidants, microbial haemolysins and ampiphiles, cationic proteins, phospholipases, fatty acids, proteinases and cytokines (an overview). Free Radic Res 1995;22(6):489-517.

(132) Ginsburg I, Kohen R, Ligumsky M. Ethanol synergizes with hydrogen peroxide, peroxyl radical, and trypsin to kill epithelial cells in culture. Free Radic Biol Med 1994;16(2):263-269.

(133) Kohen R, Shalhoub R. Prevention and induction of oxidative damage in E. coli cells by cationized proteins. Free Radic Biol Med 1994;16(5):571-580.

(134) Baluom M, Meir R, Kohen R, Rubinstein A. In vitro and in vivo evaluation of the scavenging properties of guar gum with hydroxyl and superoxide radicals. PROC CONTROL RELEASE SOC 1994(21):752-753.

(135) Ginsburg I, Mitra RS, Gibbs DF, Varani J, Kohen R. Killing of endothelial cells and release of arachidonic acid - Synergistic effects among hydrogen peroxide, membrane-damaging agents, cationic substances, and proteinases and their modulation by inhibitors. Inflammation 1993;17(3):295-319.

(136) Ginsburg I, Misgav R, Gibbs DF, Varani J, Kohen R. Chemiluminescence in activated human neutrophils - Role of buffers and scavengers. Inflammation 1993;17(3):227-243.

(137) Kohen R, Misgav R, Ginsburg I. Cimetidine modulates chemiluminescence and superoxide generation by neutrophils. Inflammopharmacology 1993;2(1):15-24.

(138) Rubinstein A, Kakunda A, Kohen R. Protection of the rat jejunal mucosa against oxidative injury by cationized superoxide dismutase. J Pharm Sci 1993;82(12):1285-1287.

(139) Kohen R. The use of cyclic voltammetry for the evaluation of oxidative damage in biological samples. J Pharmacol Toxicol Methods 1993;29(4):185-193.

(140) Kohen R, Shadmi V, Kakunda A, Rubinstein A. Prevention of oxidative damage in the rat jejunal mucosa by pectin. Br J Nutr 1993;69(3):789-800.

(141) Ginsburg I, Misgav R, Samuni A, Gibbs DF, Varani J, Kohen R. Human neutrophils stimulated by cetyltrimethyl ammonium bromide generate luminol-amplified and non-amplified chemiluminescence but no superoxide production: A paradox. Inflammopharmacology 1992;1(4):337-351.

(142) Ginsburg I, Misgav R, Pinson A, Varani J, Ward PA, Kohen R. Synergism among oxidants, proteinases, phospholipases, microbial hemolysins, cationic proteins, and cytokines. Inflammation 1992;16(5):519-538.

(143) Kohen R, Tirosh O, Gorodetsky R. The biological reductive capacity of tissues is decreased following exposure to oxidative stress: A cyclic voltammetry study of irradiated rats. Free Radic Res 1992;17(4):239-248.

(144) Kohen R, Kakunda A, Rubinstein A. The role of cationized catalase and cationized glucose oxidase in mucosal oxidative damage induced in the rat jejunum. J Biol Chem 1992;267(30):21349-21354.

(145) Kohen R, Tirosh O, Kopolovich K. The reductive capacity index of saliva obtained from donors of various ages. Exp Gerontol 1992;27(2):161-168.

(146) Kohen R, Misgav R, Ginsburg I. The sod like activity of copper: Arnosine, copper: Anserine and copper: Homocarnosine complexes. Free Radic Res 1991;12(1):179-185.

(147) Kohen R, Chevion M. Cytoplasmic Membrane Is the Target Organelle for Transition Metal Mediated Damage Induced by Paraquat in Escherichia coli. Biochemistry 1988;27(7):2597-2603.

(148) Kohen R, Yamamoto Y, Cundy KC, Ames BN. Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. Proc Natl Acad Sci U S A 1988;85(9):3175-3179.

(149) Cundy KC, Kohen R, Ames BN. Determination of 8-hydroxydeoxyguanosine in human urine: a possible assay for in vivo oxidative DNA damage. Basic Life Sci 1988;49:479-482.

(150) Higson FK, Kohen R, Chevion M. Iron enhancement of ascorbate toxicity. Free Radic Res 1988;5(2):107-115.

(151) Korbashi P, Kohen R, Katzhendler J, Chevion M. Iron mediates paraquat toxicity in Escherichia coli. J Biol Chem 1986;261(27):12472-12476.

(152) Kohen R, Szyf M, Chevion M. Quantitation of single- and double-strand DNA breaks in vitro and in vivo. Anal Biochem 1986;154(2):485-491.

(153) Kohen R, Chevion M. Involvement of iron and copper in biological damage that is induced by oxygen free radicals. J Free Radic Biol Med 1985;1(5-6):339-340.

(154) Kohen R, Chevion M. Paraquat toxicity is enhanced by iron and reduced by desferrioxamine in laboratory mice. Biochem Pharmacol 1985;34(10):1841-1843.

(155) Kohen R, Chevion M. Letter to the editor. J Free Radic Biol Med 1985;1(5-6):339.

(156) Kohen R, Chevion M, Czapski G. Transition metals potentiate paraquat toxicity. Free Radic Res 1985;1(2):79-88.

(157) Kohen R, Friedman M, Chevion M. Iron-treated hydroxyapatite: Structure and function. Pharm Acta Helv 1984;59(8):228-234.