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School of Pharmacy : Rubinstein Abraham

Researchers

 Last updated Septmber 2023 - School of Pharmacy

List of Publications

1.

Gabbay RS, Rubinstein A. Synchronizing the release rates of topotecan and paclitaxel from a self-eroding crosslinked chitosan – PLGA platform. International Journal of Pharmaceutics [Internet]. 2022;623. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85132892803&doi=10.1016%252fj.ijpharm.2022.121945&partnerID=40&md5=92c7a769fcf74f509ce5f8ec20f3a1be

2.

Sharon Gabbay R, Rubinstein A. Controlling the release rate of topotecan from PLGA spheres and increasing its cytotoxicity towards glioblastoma cells by co-loading with calcium chloride. International Journal of Pharmaceutics [Internet]. 2021;602. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104925496&doi=10.1016%252fj.ijpharm.2021.120616&partnerID=40&md5=876d42192c029bf0646601415062de07

3.

Kenett RS, Rubinstein A. Generalizing research findings for enhanced reproducibility: an approach based on verbal alternative representations. Scientometrics [Internet]. 2021;126(5):4137–51. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102300712&doi=10.1007%252fs11192-021-03914-1&partnerID=40&md5=7091289454842cc2fea36969973829ae

4.

Gabbay RS, Kenett RS, Scaffaro R, Rubinstein A. Synchronizing the release rates of salicylate and indomethacin from degradable chitosan hydrogel and its optimization by definitive screening design. European Journal of Pharmaceutical Sciences [Internet]. 2018;125:102–9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054181011&doi=10.1016%252fj.ejps.2018.09.020&partnerID=40&md5=7f08b56e4c7da2838f78aded3b9708e4

5.

Tiwari S, Tirosh B, Rubinstein A. Increasing the affinity of cationized polyacrylamide-paclitaxel nanoparticles towards colon cancer cells by a surface recognition peptide. International Journal of Pharmaceutics [Internet]. 2017;531(1):281–91. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028376117&doi=10.1016%252fj.ijpharm.2017.08.092&partnerID=40&md5=033f9d4862de6a199839005ac43b4dd6

6.

Bloch MBD, Yavin E, Nissan A, Ariel I, Kenett R, Brass D, et al. The effect of linker type and recognition peptide conjugation chemistry on tissue affinity and cytotoxicity of charged polyacrylamide. Journal of Controlled Release [Internet]. 2017;257:102–17. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85008423071&doi=10.1016%252fj.jconrel.2016.06.038&partnerID=40&md5=a453bbccb8ca79c28fc5c6d5e761a21c

7.

Abutbul E, Rubinstein A. Colon-targeted delivery systems [Internet]. Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development. 2016. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85051968465&partnerID=40&md5=80cfe3a1c80c0b80dfe9f3d60d62233e

8.

Kolevzon N, Hashoul D, Naik S, Rubinstein A, Yavin E. Single point mutation detection in living cancer cells by far-red emitting PNA-FIT probes. Chemical Communications [Internet]. 2016;52(11):2405–7. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84956625431&doi=10.1039%252fc5cc07502e&partnerID=40&md5=ceefc604e21d959c63d255b2c09b8ad9

9.

Perlstein H, Turovsky T, Gimeson P, Cohen R, Rubinstein A, Danino D, et al. Thermotropic behavior of celecoxib-loaded beta-casein micelles: Relevance to the improved bioavailability. European Journal of Nanomedicine [Internet]. 2015;7(4):303–12. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84947417437&doi=10.1515%252fejnm-2015-0023&partnerID=40&md5=01a468713ca50a62d24bdfd132b04d5e

10.

Bloch M, Kenett R, Jablonowski L, Wheatley M, Yavin E, Rubinstein A. A multifactorial analysis of complex pharmaceutical platforms: An application of design of experiments to targetable polyacrylamide and ultrasound contrast agents. Polymers for Advanced Technologies [Internet]. 2015;26(7):898–905. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84931957972&doi=10.1002%252fpat.3531&partnerID=40&md5=c085651b98765950b7841866464dadb1

11.

Bloch M, Jablonowski L, Yavin E, Moradov D, Djavsarov I, Nyska A, et al. Multi-modal detection of colon malignancy by NIR-tagged recognition polymers and ultrasound contrast agents. International Journal of Pharmaceutics [Internet]. 2015;478(2):504–16. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84916899085&doi=10.1016%252fj.ijpharm.2014.11.066&partnerID=40&md5=e0a380cdb22b9a6317b4ea9bf5c82651

12.

Moradov D, Shifrin H, Harel E, Nadler-Milbauer M, Weinstock M, Srebnik M, et al. The anti-inflammatory activity of a novel fused-cyclopentenone phosphonate and its potential in the local treatment of experimental colitis. Gastroenterology Research and Practice [Internet]. 2015;2015. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84928473623&doi=10.1155%252f2015%252f939483&partnerID=40&md5=c2fc698d2bc7c43330ce143f4f6f244b

13.

Perlstein H, Bavli Y, Turovsky T, Rubinstein A, Danino D, Stepensky D, et al. Beta-casein nanocarriers of celecoxib for improved oral bioavailability. European Journal of Nanomedicine [Internet]. 2014;6(4):217–26. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84917698902&doi=10.1515%252fejnm-2014-0025&partnerID=40&md5=83f441e37c0d9fa7a3b390465890ebfe

14.

Kam Y, Rubinstein A, Naik S, Djavsarov I, Halle D, Ariel I, et al. Detection of a long non-coding RNA (CCAT1) in living cells and human adenocarcinoma of colon tissues using FIT-PNA molecular beacons. Cancer Letters [Internet]. 2014;352(1):90–6. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84906053873&doi=10.1016%252fj.canlet.2013.02.014&partnerID=40&md5=5c6dfc6222bfefd1dedefeeec310e2f7

15.

Cohen S, Pellach M, Kam Y, Grinberg I, Corem-Salkmon E, Rubinstein A, et al. Synthesis and characterization of near IR fluorescent albumin nanoparticles for optical detection of colon cancer. Materials Science and Engineering C [Internet]. 2013;33(2):923–31. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84871370797&doi=10.1016%252fj.msec.2012.11.022&partnerID=40&md5=ad348f401518883549598f0bd5fc999a

16.

Bloch M, Kam Y, Yavin E, Moradov D, Nissan A, Ariel I, et al. The relative roles of charge and a recognition peptide in luminal targeting of colorectal cancer by fluorescent polyacrylamide. European Journal of Pharmaceutical Sciences [Internet]. 2012;47(5):904–13. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84868693403&doi=10.1016%252fj.ejps.2012.09.003&partnerID=40&md5=5a07a35221879f1a9ee8fea880e5dd67

17.

Smoum R, Rubinstein A, Dembitsky VM, Srebnik M. Boron containing compounds as protease inhibitors. Chemical Reviews [Internet]. 2012;112(7):4156–220. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84865088209&doi=10.1021%252fcr608202m&partnerID=40&md5=befe0ba2b42b444fcade9af147a80358

18.

Moradov D, Rubinstein A, Gelman D, Srebnik M. Molybdenum-mediated deconjugation of α,β-unsaturated fused-cyclopentenone phosphonates. Synthesis [Internet]. 2012;44(8):1258–62. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859602926&doi=10.1055%252fs-0031-1289751&partnerID=40&md5=3605d33d412be462f2de3163ae0e194a

19.

Kam Y, Rubinstein A, Nissan A, Halle D, Yavin E. Detection of endogenous K-ras mRNA in living cells at a single base resolution by a PNA molecular beacon. Molecular Pharmaceutics [Internet]. 2012;9(3):685–93. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84858019925&doi=10.1021%252fmp200505k&partnerID=40&md5=ffb3bc451bc69fe821d229d621b008c0

20.

Khazanov E, Yavin E, Pascal A, Nissan A, Kohl Y, Reimann-Zawadzki M, et al. Detecting a secreted gastric cancer biomarker molecule by targeted nanoparticles for real-time diagnostics. Pharmaceutical Research [Internet]. 2012;29(4):983–93. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84862653638&doi=10.1007%252fs11095-011-0638-8&partnerID=40&md5=252c85a8308115a5b105b45037a51267

21.

Nadler-Milbauer M, Apter L, Haupt Y, Haupt S, Barenholz Y, Minko T, et al. Synchronized release of Doxil and Nutlin-3 by remote degradation of polysaccharide matrices and its possible use in the local treatment of colorectal cancer. Journal of Drug Targeting [Internet]. 2011;19(10):859–73. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-81255138300&doi=10.3109%252f1061186X.2011.622401&partnerID=40&md5=8c8e9b4448f88d226a566e330942434b

22.

Harel E, Rubinstein A, Nissan A, Khazanov E, Milbauer M, Barenholz Y, et al. Enhanced transferrin receptor expression by proinflammatory cytokines in enterocytes as a means for local delivery of drugs to inflamed gut mucosa. PLoS ONE [Internet]. 2011;6(9). Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-80052443097&doi=10.1371%252fjournal.pone.0024202&partnerID=40&md5=c5eca426f97b119f16e063cb0ad6fee6

23.

Harel E, Rubinstein A, Chen W, Breuer E, Tirosh B. Aminoalkylcarbamoylphosphonates reduce TNFα release from activated immune cells. Bioorganic and Medicinal Chemistry Letters [Internet]. 2010;20(22):6518–23. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-77958056213&doi=10.1016%252fj.bmcl.2010.09.048&partnerID=40&md5=4a24acf30c63c42e40947b03a65bf0f3

24.

Nadler Milabuer M, Kam Y, Rubinstein A. Orally Administered Drug Delivery Systems to the Colon [Internet]. Oral Controlled Release Formulation Design and Drug Delivery: Theory to Practice. 2010. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885559239&doi=10.1002%252f9780470640487.ch14&partnerID=40&md5=b6e10c597c5ccdb7cfbedd5555c9a6a5

25.

Khazanov E, Emmanuel N, Azab AK, Barenholz Y, Yavin E, Rubinstein A. Specific detection of gastric α-antitrypsin by immobilized trypsin on PolyHEMA films. Molecular Pharmaceutics [Internet]. 2010;7(4):944–52. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-77955248512&doi=10.1021%252fmp100076x&partnerID=40&md5=22ca85c58950e1c623fe8f58aa607cf7

26.

Tirosh B, Khatib N, Barenholz Y, Nissan A, Rubinstein A. Transferrin as a luminal target for negatively charged liposomes in the inflamed colonic mucosa. Molecular Pharmaceutics [Internet]. 2009;6(4):1083–91. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-68249087581&doi=10.1021%252fmp9000926&partnerID=40&md5=ab730b5364313b4f2f5facec3b521196

27.

Sinelnikove Y, Rubinstein A, Srebnik M, Quntar AAAA. Direct formation of cyclobutenylphosphonates from 1-alkynylphosphonates and Cp2ZrCl2/2EtMgCl/2CuCl. Tetrahedron Letters [Internet]. 2009;50(8):867–9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-58149484914&doi=10.1016%252fj.tetlet.2008.11.108&partnerID=40&md5=e7f0080980e361b7dfc75fbb4e1668df

28.

Moradov D, Quntar AAAA, Youssef M, Smoum R, Rubinstein A, Srebnik M. Mo(CO) 6-mediated intramolecular pauson-Khand reaction of substituted Diethyl 3-Allyloxy-1-Propynylphosphonates. Journal of Organic Chemistry [Internet]. 2009;74(3):1029–33. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-64649100098&doi=10.1021%252fjo801988k&partnerID=40&md5=0089e705a25f001b2c3413db656afdf6

29.

Nadler-Milbauer M, Azab AK, Kleinstern J, Barenholz Y, Rubinstein A. In vitro and in vivo analysis of pulsatile biodegradation of mucoadhesive hydrogels. Journal of Drug Delivery Science and Technology [Internet]. 2009;19(4):247–55. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-69249122534&doi=10.1016%2fS1773-2247%2809%2950048-2&partnerID=40&md5=3e2db241052e7410ff4ca6256c3e6d10

30.

Azab AK, Kleinstern J, Srebnik M, Rubinstein A. The metastatic stage-dependent mucosal expression of sialic acid is a potential marker for targeting colon cancer with cationic polymers. Pharmaceutical Research [Internet]. 2008;25(2):379–86. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-39149122202&doi=10.1007%252fs11095-007-9330-4&partnerID=40&md5=ab0196d6147934179270451b05e0bc60

31.

Al Quntar AAA, Botvinik A, Rubinstein A, Srebnik M. Synthesis of 3-hydroxy-1-alkenylboronates via phosphine stabilized borylzirconacyclopropenes. Chemical Communications [Internet]. 2008;(43):5589–91. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-55849087318&doi=10.1039%252fb811287h&partnerID=40&md5=4aa67f76d62871563341a110b5082e25

32.

Azab AK, Kleinstern J, Doviner V, Orkin B, Srebnik M, Nissan A, et al. Prevention of tumor recurrence and distant metastasis formation in a breast cancer mouse model by biodegradable implant of 131I-norcholesterol. Journal of Controlled Release [Internet]. 2007;123(2):116–22. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-35348920801&doi=10.1016%252fj.jconrel.2007.07.014&partnerID=40&md5=d7bcb21b4c15b8d838d945253952b334

33.

Azab AK, Doviner V, Orkin B, Kleinstern J, Srebnik M, Nissan A, et al. Biocompatibility evaluation of crosslinked chitosan hydrogels after subcutaneous and intraperitoneal implantation in the rat. Journal of Biomedical Materials Research - Part A [Internet]. 2007;83(2):414–22. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-35048867035&doi=10.1002%252fjbm.a.31256&partnerID=40&md5=648d2594a6f714200910e445c0804131

34.

Haupt S, Kleinstern J, Haupt Y, Rubinstein A. Celecoxib can induce cell death independently of cyclooxygenase-2, p53, Mdm2, c-Abl and reactive oxygen species. Anti-Cancer Drugs [Internet]. 2006;17(6):609–19. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-33747626285&doi=10.1097%252f01.cad.0000215055.40072.42&partnerID=40&md5=cb0e2f294e8f14571ae4b1cb3964b33b

35.

Shibli A, Smoum R, Goldberg I, Rubinstein A, Srebnik M. α-Amino boronates as cyanoborane complexes: Crystal structure and inhibition properties for the serine proteases: α-chymotrypsin and trypsin. Applied Organometallic Chemistry [Internet]. 2006;20(7):459–62. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-33746338565&doi=10.1002%252faoc.1095&partnerID=40&md5=84db75f61017b6b57ed6b3a25d808fe1

36.

Jabbour A, Smoum R, Takrouri K, Shalom E, Zaks B, Steinberg D, et al. Pharmacologically active boranes. Pure and Applied Chemistry [Internet]. 2006;78(7):1425–53. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-33746265878&doi=10.1351%252fpac200678071425&partnerID=40&md5=da10c2e840b83bd612c6975c968bce40

37.

Haupt S, Zioni T, Gati I, Kleinstern J, Rubinstein A. Luminal delivery and dosing considerations of local celecoxib administration to colorectal cancer. European Journal of Pharmaceutical Sciences [Internet]. 2006;28(3):204–11. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-33646802666&doi=10.1016%252fj.ejps.2006.02.001&partnerID=40&md5=730a7aa148f3b5438370a2412454ec9f

38.

Azab AK, Orkin B, Doviner V, Nissan A, Klein M, Srebnik M, et al. Crosslinked chitosan implants as potential degradable devices for brachytherapy: In vitro and in vivo analysis. Journal of Controlled Release [Internet]. 2006;111(3):281–9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-33645302350&doi=10.1016%252fj.jconrel.2005.12.014&partnerID=40&md5=ffb3abcd2cc05144755f7e32bc0b74c8

39.

Jubeh TT, Nadler-Milbauer M, Barenholz Y, Rubinstein A. Local treatment of experimental colitis in the rat by negatively charged liposomes of catalase, TMN and SOD. Journal of Drug Targeting [Internet]. 2006;14(3):155–63. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-33745069019&doi=10.1080%252f10611860600648429&partnerID=40&md5=37775e299a4c2c07c7e82ad0a7e8c17c

40.

Rubinstein A. Gastrointestinal anatomy, physiology and permeation pathways [Internet]. Enhancement in Drug Delivery. 2006. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-77949414034&partnerID=40&md5=07dd3b3c9cecfe455f1244b0e29a6171

41.

Smoum R, Rubinstein A, Srebnik M. Chitosan-pentaglycine-phenylboronic acid conjugate: A potential colon-specific platform for calcitonin. Bioconjugate Chemistry [Internet]. 2006;17(4):1000–7. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-33746671262&doi=10.1021%252fbc050357y&partnerID=40&md5=1d47947c5d007479415dd4be4587b383

42.

Azab AK, Srebnik M, Doviner V, Rubinstein A. Targeting normal and neoplastic tissues in the rat jejunum and colon with boronated, cationic acrylamide copolymers. Journal of Controlled Release [Internet]. 2005;106(1–2):14–25. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-23744513109&doi=10.1016%252fj.jconrel.2005.03.015&partnerID=40&md5=e225f6fc39bb7e011f847081a15f4449

43.

Smoum R, Rubinstein A, Srebnik M. Noncovalent inhibition of the serine proteases, α-chymotrypsin and trypsin by trifluoro(organo)borates. Organic and Biomolecular Chemistry [Internet]. 2005;3(5):941–4. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-15244358939&doi=10.1039%252fb415957h&partnerID=40&md5=8aafcd9879bec45758f6604899583aee

44.

Rubinstein A. Colonic drug delivery. Drug Discovery Today: Technologies [Internet]. 2005;2(1):33–7. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-21744443432&doi=10.1016%252fj.ddtec.2005.05.021&partnerID=40&md5=70ddfb08ca4917ebb563162a9e0b853e

45.

Jubeh TT, Antler S, Haupt S, Barenholz Y, Rubinstein A. Local prevention of oxidative stress in the intestinal epithelium of the rat by adhesive liposomes of superoxide dismutase and tempamine. Molecular Pharmaceutics [Internet]. 2005;2(1):2–11. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-14644433050&doi=10.1021%252fmp0499095&partnerID=40&md5=b03bf9157c3227c15c9dc4fb73b44986

46.

Jubeh TT, Barenholz Y, Rubinstein A. Differential adhesion of normal and inflamed rat colonic mucosa by charged liposomes. Pharmaceutical Research [Internet]. 2004;21(3):447–53. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-1542406587&doi=10.1023%252fB%253aPHAM.0000019298.29561.cd&partnerID=40&md5=195f400cb7e6837c98e35636aef1d684

47.

David A, Kopečková P, Minko T, Rubinstein A, Kopeček J. Design of a multivalent galactoside ligand for selective targeting of HPMA copolymer-doxorubicin conjugates to human colon cancer cells. European Journal of Cancer [Internet]. 2004;40(1):148–57. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0346996532&doi=10.1016%252fj.ejca.2003.07.001&partnerID=40&md5=dc580fac87e0ca70ccc88828acce5f45

48.

Smoum R, Rubinstein A, Srebnik M. Combined 1H, 13C and 11B NMR and mass spectral assignments of boronate complexes of D-(+)-glucose, D-(+)-mannose, methyl-α-D-glucopyranoside, methyl-β-D-galactopyranoside and methyl-α-D-mannopyranoside. Magnetic Resonance in Chemistry [Internet]. 2003;41(12):1015–20. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0348014895&doi=10.1002%252fmrc.1301&partnerID=40&md5=669e03c54cb7d36a318b2f2ee82552a4

49.

Smoum R, Rubinstein A, Srebnik M. A study of the effect on nucleophilic hydrolytic activity of pancreatic elastase, trypsin, chymotrypsin, and leucine aminopeptidase by boronic acids in the presence of arabinogalactan: A subsequent study on the hydrolytic activity of chymotrypsin by boronic acids in the presence of mono-, di-, and trisaccharides. Bioorganic Chemistry [Internet]. 2003;31(6):464–74. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0242552301&doi=10.1016%252fj.bioorg.2003.08.004&partnerID=40&md5=bea568354205810f09d89656d0e20792

50.

Haupt S, Rubinstein A. The colon as a possible target for orally administered peptide and protein drugs. Critical Reviews in Therapeutic Drug Carrier Systems [Internet]. 2002;19(6):499–551. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0038546904&doi=10.1615%252fCritRevTherDrugCarrierSyst.v19.i6.10&partnerID=40&md5=a2add4ca0f1128032beed3b5af9dfda8

51.

David A, Kopecková P, Kopeček J, Rubinstein A. The role of galactose, lactose, and galactose valency in the biorecognition of N-(2-hydroxypropyl)methacrylamide copolymers by human colon adenocarcinoma cells. Pharmaceutical Research [Internet]. 2002;19(8):1114–22. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036690721&doi=10.1023%252fA%253a1019885807067&partnerID=40&md5=2a6c94fb2709810187c9270c73f078b9

52.

Haupt S, Gil E, Tirosh R, Klinger E, Gad A, Rubinstein A. Regional peptide uptake study in the rat intestinal mucosa: Glatiramer acetate as a model drug. Pharmaceutical Research [Internet]. 2002;19(6):832–7. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036291905&doi=10.1023%252fA%253a1016109016942&partnerID=40&md5=6f0500d07e3b9c8eea8a79bf2a258b97

53.

Baluom M, Friedman M, Rubinstein A. Improved intestinal absorption of sulpiride in rats with synchronized oral delivery systems. Journal of Controlled Release [Internet]. 2001;70(1–2):139–47. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035966544&doi=10.1016%2fS0168-3659%2800%2900337-0&partnerID=40&md5=48a4482b070e9d6c925950c61cadc93e

54.

David A, Kopečková P, Rubinstein A, Kopeček J. Enhanced biorecognition and internalization of HPMA copolymers containing multiple or multivalent carbohydrate side-chains by human hepatocarcinoma cells. Bioconjugate Chemistry [Internet]. 2001;12(6):890–9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035206993&doi=10.1021%252fbc010026v&partnerID=40&md5=c8ca59cf7338f7ac41bcf07d90d7e5b7

55.

Blau S, Levin N, Schwartz B, Rubinstin EA. Adsorption of cationized bovine serum albumin onto epithelial crypt fractions of the rat colon. Journal of Pharmaceutical Sciences [Internet]. 2001;90(10):1516–22. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034768651&doi=10.1002%252fjps.1102&partnerID=40&md5=56e4093b80cb6ae7268e5186cef3b02d

56.

Blau S, Kohen R, Bass P, Rubinstein A. Relation between colonic inflammation severity and total low-molecular- weight antioxidant profiles in experimental colitis. Digestive Diseases and Sciences [Internet]. 2000;45(6):1180–7. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034049804&doi=10.1023%252fA%253a1005510321278&partnerID=40&md5=e1ecd2e2b48c09417073b1f6b5857c52

57.

Gliko-Kabir I, Yagen B, Baluom M, Rubinstein A. Phosphated crosslinked guar for colon-specific drug delivery - II. In vitro and in vivo evaluation in the rat. Journal of Controlled Release [Internet]. 2000;63(1–2):129–34. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033977611&doi=10.1016%2fS0168-3659%2899%2900180-7&partnerID=40&md5=10e368b3296d8a033d249bba42c9eab9

58.

Gliko-Kabir I, Yagen B, Penhasi A, Rubinstein A. Phosphated crosslinked guar for colon-specific drug delivery - I. Preparation and physicochemical characterization. Journal of Controlled Release [Internet]. 2000;63(1–2):121–7. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033972597&doi=10.1016%2fS0168-3659%2899%2900179-0&partnerID=40&md5=2075412c5ebdc9a23b46997dd52c8e18

59.

Rubinstein A, Blau S, Bass P, Kohen R. The effect of adhesive antioxidant enzymes on experimental colitis in the rat. ACS Symposium Series [Internet]. 2000;752:78–89. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0041779985&doi=10.1021%252fbk-2000-0752.ch009&partnerID=40&md5=89bc9a55b0dd5e61e39f9a429cc5ec9e

60.

Baluom M, Friedman M, Rubinstein A. Erratum: The importance of intestinal residence time of absorption enhancer on drug absorption and implication on formulative considerations (International Journal of Pharmaceutics (1998) 176 (21-30) PII: S0378517398002889). International Journal of Pharmaceutics [Internet]. 2000;193(2):265–6. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033989629&doi=10.1016%2fS0378-5173%2899%2900396-8&partnerID=40&md5=9a1ec77e9c868929885bd99c7fa7206b

61.

Rubinstein A. Natural polysaccharides as targeting tools of drugs to the human colon. Drug Development Research [Internet]. 2000;50(3–4):435–9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033819356&doi=10.1002%2f1098-2299%28200007%2f08%2950%3a3%2f4%3c435%3a%3aAID-DDR26%3e3.0.CO%3b2-5&partnerID=40&md5=67588d4a4c9700f1014723ebc671ca02

62.

Blau S, Jubeh TT, Haupt SM, Rubinstein A. Drug targeting by surface cationization. Critical Reviews in Therapeutic Drug Carrier Systems [Internet]. 2000;17(5):425–65. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033778347&doi=10.1615%252fcritrevtherdrugcarriersyst.v17.i5.10&partnerID=40&md5=9541ff862e896e874c2097aa76f52204

63.

Baluom M, Friedman M, Assaf P, Haj-Yehia AI, Rubinstein A. Synchronized release of sulpiride and sodium decanoate from HPMC matrices: A rational approach to enhance sulpiride absorption in the rat intestine. Pharmaceutical Research [Internet]. 2000;17(9):1071–6. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033762244&doi=10.1023%252fA%253a1026449527891&partnerID=40&md5=920604dfabb83a02c2077ad3821be292

64.

Blau S, Kohen R, Bass P, Rubinstein A. The effect of local attachment of cationized antioxidant enzymes on experimental colitis in the rat. Pharmaceutical Research [Internet]. 2000;17(9):1077–84. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033761876&doi=10.1023%252fA%253a1026401611961&partnerID=40&md5=69d1c7a7362f1a82653cb9e87decb84a

65.

Blau S, Rubinstein A, Bass P, Singaram C, Kohen R. Differences in the reducing power along the rat GI tract: Lower antioxidant capacity of the colon. Molecular and Cellular Biochemistry [Internet]. 1999;194(1–2):185–91. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033053890&doi=10.1023%252fA%253a1006994800272&partnerID=40&md5=600c540abf06f499e9daf738dbd5b019

66.

Gliko-Kabir I, Penhasi A, Rubinstein A. Characterization of crosslinked guar by thermal analysis. Carbohydrate Research [Internet]. 1999;316(1–4):6–13. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033041060&doi=10.1016%2fS0008-6215%2899%2900025-7&partnerID=40&md5=356e503f882c99a38e266f955a13119c

67.

Rubinstein A, Baluom M, Friedman M. Role of synchronous release of sodium decanoate on sulpiride absorption in the intestine of the rat. In: American Chemical Society, Polymer Preprints, Division of Polymer Chemistry [Internet]. 1999. p. 263–4. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033095155&partnerID=40&md5=e059d63adb16a3e6ad70a39fd015e7ee

68.

Rubinstein A, Blau S, Bass P, Kohen R. Effect of adhesive antioxidant enzymes on experimental colitis in the rat. In: American Chemical Society, Polymer Preprints, Division of Polymer Chemistry [Internet]. 1999. p. 316–7. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033092659&partnerID=40&md5=80551f200de2cc883879d95c4f7a78e9

69.

Baluom M, Friedman M, Rubinstein A. Erratum: The importance of intestinal residence time of absorption enhancer on drug absorption and implication on formulative considerations (International Journal of Pharmaceutics 176 (1998) (21-30) PII: S0378517398002889). International Journal of Pharmaceutics [Internet]. 1999;185(1):123–4. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032774996&doi=10.1016%2fS0378-5173%2899%2900199-4&partnerID=40&md5=5fbc01e8254a016df03dbba3c9356b31

70.

Baluom M, Friedman M, Rubinstein A. The involvement of P-glycoprotein in intestinal absorption and its implication on the design of oral delivery systems of sulpiride. Proceedings of the Controlled Release Society [Internet]. 1999;(26):329–30. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032713022&partnerID=40&md5=41dfcaf6e513fc6dc8a6993138c5062c

71.

Baluom M, Friedman M, Rubinstein A. The importance of intestinal residence time of absorption enhancer on drug absorption and implication on formulative considerations. International Journal of Pharmaceutics [Internet]. 1998;176(1):21–30. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031757846&doi=10.1016%2fS0378-5173%2898%2900288-9&partnerID=40&md5=5761150ee1717e2440b11a6901758293

72.

Gliko-Kabir I, Yagen B, Penhasi A, Rubinstein A. Low swelling, crosslinked guar and its potential use as colon-specific drug carrier. Pharmaceutical Research [Internet]. 1998;15(7):1019–25. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031870290&doi=10.1023%252fA%253a1011921925745&partnerID=40&md5=a64408e62ff805333d7af8500cc54a9c

73.

Tirosh B, Rubinstein A. Migration of adhesive and nonadhesive particles in the rat intestine under altered mucus secretion conditions. Journal of Pharmaceutical Sciences [Internet]. 1998;87(4):453–6. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031897818&doi=10.1021%252fjs9703380&partnerID=40&md5=95e7bee62cbfbaf08b93b2e69d7cbc4a

74.

Blau S, Kohen R, Bass P, Rubinstein A. Local treatment with cationized antioxidant enzymes reduces experimental colitis in the rat. Proceedings of the Controlled Release Society [Internet]. 1998;(25):8–9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031844022&partnerID=40&md5=48a98bf5b6c506fc5c7ba7988680ebbf

75.

David A, Yagen B, Sintov A, Rubinstein A. Acrylic polymers for colonspecific drug delivery. STP Pharma Sciences [Internet]. 1997;7(6):546–54. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031544302&partnerID=40&md5=11a39ca358dea2b3831357ae8b7139d3

76.

Baluom M, Friedman DI, Rubinstein A. Absorption enhancement of calcitonin in the rat intestine by carbopol-containing submicron emulsions. International Journal of Pharmaceutics [Internet]. 1997;154(2):235–43. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030877143&doi=10.1016%2fS0378-5173%2897%2900140-3&partnerID=40&md5=562d2f1863675e83ad56f633efaff89e

77.

Rubinstein A, Radai R, Friedman M, Fischer P, Rokem JS. The effect of intestinal bacteria adherence on drug diffusion through solid films under stationary conditions. Pharmaceutical Research [Internet]. 1997;14(4):503–7. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030981483&doi=10.1023%252fA%253a1012159818727&partnerID=40&md5=3b212b08e18136d021f1410517efe056

78.

Rubinstein A, Tirosh B, Baluom M, Nassar T, David A, Radai R, et al. The rationale for peptide drug delivery to the colon and the potential of polymeric carriers as effective tools. Journal of Controlled Release [Internet]. 1997;46(1–2):59–73. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031046957&doi=10.1016%2fS0168-3659%2896%2901582-9&partnerID=40&md5=2343833d24883400f9d15d13d1919ca3

79.

Adkin DA, Kenyon CJ, Lerner EI, Landau I, Strauss E, Caron D, et al. The use of scintigraphy to provide “proof of concept” for novel polysaccharide preparations designed for colonic drug delivery. Pharmaceutical Research [Internet]. 1997;14(1):103–7. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031042162&doi=10.1023%252fA%253a1012019820603&partnerID=40&md5=b49bbd17ea8bcc472787c01f26a122ef

80.

Tirosh B, Baluom M, Nassar T, Friedman M, Rubinstein A. The effect of Eudragit RL-100 on the mechanical and mucoadhesion properties of polycarbophil dosage forms. Journal of Controlled Release [Internet]. 1997;45(1):57–64. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031016099&doi=10.1016%2fS0168-3659%2896%2901545-3&partnerID=40&md5=c41463fbc937912bfb0e0ffd25342699

81.

Rubinstein A, Gliko-Kabir I, Penhasi A, Yagen B. Enzyme dependent release of budesonide from crosslinked guar hydrogels. Proceedings of the Controlled Release Society [Internet]. 1997;(24):839–40. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030849089&partnerID=40&md5=54ceacf283c4fe7b4bdb38a0f62cd94e

82.

Sintov A, Simberg M, Rubinstein A. Absorption enhancement of captopril in the rat colon as a putative method for captopril delivery by extended release formulations. International Journal of Pharmaceutics [Internet]. 1996;143(1):101–6. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030601863&doi=10.1016%2fS0378-5173%2896%2904682-0&partnerID=40&md5=26bdd2415fd205ed00d5ac64f26f89cc

83.

Sintov A, Di-Capua N, Rubinstein A. Cross-linked chondroitin sulphate: characterization for drug delivery purposes. Biomaterials [Internet]. 1995;16(6):473–8. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029278168&doi=10.1016%2f0142-9612%2895%2998820-5&partnerID=40&md5=2084c6bdfa2a5aa94d71021be302c926

84.

Tirosh B, Nasser T, Friedman M, Rubinstein A. Eudragit RL-100 as a physical stabilizer of polycarbophil hydrogels. Proceedings of the Controlled Release Society [Internet]. 1995;(22):358–9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029088482&partnerID=40&md5=63885f7dec26321a22152afbc8370de3

85.

Rubinstein A, Radai R. In vitro and in vivo analysis of colon specificity of calcium pectinate formulations. European Journal of Pharmaceutics and Biopharmaceutics [Internet]. 1995;41(5):291–5. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028892564&partnerID=40&md5=63f2396c37040e907fc1a173ed11bba7

86.

Rubinstein A, Gliko-Kabir I. Synthesis and swelling-dependent enzymatic degradation of borax-modified guar gum for colonic delivery purposes. STP Pharma Sciences [Internet]. 1995;5(1):41–6. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028857279&partnerID=40&md5=77b50d9e70c105735f0b60129dbbf7f9

87.

Rubinstein A. Approaches and opportunities in colon-specific drug delivery. Critical Reviews in Therapeutic Drug Carrier Systems [Internet]. 1995;12(2–3):101–49. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028832474&doi=10.1615%252fCritRevTherDrugCarrierSyst.v12.i2-3.10&partnerID=40&md5=cf6dda7be567439afab5d253924bafb6

88.

Rubinstein A, Tirosh B. Mucus Gel Thickness and Turnover in the Gastrointestinal Tract of the Rat: Response to Cholinergic Stimulus and Implication for Mucoadhesion. Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists [Internet]. 1994;11(6):794–9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028366107&doi=10.1023%252fA%253a1018961204325&partnerID=40&md5=d70343de712724874b9d4723530fde9a

89.

Baluom M, Meir R, Kohen R, Rubinstein A. In vitro and in vivo evaluation of the scavenging properties of guar gum with hydroxyl and superoxide radicals. Proceedings of the Controlled Release Society [Internet]. 1994;(21):752–3. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027996672&partnerID=40&md5=271b4bbd003ccf1ba3cb3d2fce43fc6f

90.

Sintov A, Ankol S, Levy DP, Rubinstein A. Enzymatic cleavage of disaccharide side groups in insoluble synthetic polymers: A new method for specific delivery of drugs to the colon. Biomaterials [Internet]. 1993;14(7):483–90. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027610345&doi=10.1016%2f0142-9612%2893%2990233-R&partnerID=40&md5=b35ef488ef5f743cfd6fefab54226436

91.

Rubinstein A, Kakunda A, Kohen R. Protection of the rat jejunal mucosa against oxidative injury by cationized superoxide dismutase. Journal of Pharmaceutical Sciences [Internet]. 1993;82(12):1285–7. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027515021&doi=10.1002%252fjps.2600821222&partnerID=40&md5=86a9bfb433cb528b08ee8e97c25bc222

92.

Rubinstein A, Radai R, Ezra M, Pathak S, Rokem JS. In Vitro Evaluation of Calcium Pectinate: A Potential Colon-Specific Drug Delivery Carrier. Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists [Internet]. 1993;10(2):258–63. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027476168&doi=10.1023%252fA%253a1018995029167&partnerID=40&md5=16012b19fc082f5e44b58eb7ff3bd4a4

93.

Kohen R, Shadmi V, Kakunda A, Rubinstein A. Prevention of oxidative damage in the rat jejunal mucosa by pectin. British Journal of Nutrition [Internet]. 1993;69(3):789–800. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027289687&doi=10.1079%252fBJN19930079&partnerID=40&md5=85cdf9fefbc4f7150089da6d6cf81092

94.

Tirosh B, Rubinstein A. The varied mucus secretory response of the rat GI tract to cholinergic stimulus. Proceedings of the Controlled Release Society [Internet]. 1993;(20):186–7. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027268090&partnerID=40&md5=525b81eebe15684bc0161014508a51fb

95.

Radai R, Rubinstein A. In vitro and in vivo analysis of colon specificity of calcium pectinate formulations. Proceedings of the Controlled Release Society [Internet]. 1993;(20):330–1. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027201994&partnerID=40&md5=1dea9fdae48a3b5e63aec85355cbefde

96.

Rubinstein A, Nakar D, Sintov A. Chondroitin sulfate: A potential biodegradable carrier for colon-specific drug delivery. International Journal of Pharmaceutics [Internet]. 1992;84(2):141–50. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026744322&doi=10.1016%2f0378-5173%2892%2990054-6&partnerID=40&md5=7fcc80423134ea5ed4127bda97200dae

97.

Kohen R, Kakunda A, Rubinstein A. The role of cationized catalase and cationized glucose oxidase in mucosal oxidative damage induced in the rat jejunum. Journal of Biological Chemistry [Internet]. 1992;267(30):21349–54. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026785654&partnerID=40&md5=1b27fc477c9cba50c159f700ae750e5b

98.

Rubinstein A, Nakar D, Sintov A. Colonic drug delivery: Enhanced release of indomethacin from cross-linked chondroitin matrix in rat cecal content. Pharmaceutical Research [Internet]. 1992;9(2):276–8. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026501131&doi=10.1023%252fa%253a1018910128452&partnerID=40&md5=d50fe4983654c34c17d75b1ec19146b5

99.

Rubinstein A, Ezra M, Rokem JS. Adhesion of bacteria on pectin casted films. Microbios [Internet]. 1992;70(284–285):163–70. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026466367&partnerID=40&md5=f6e6fdc0411917c9c07e19efa8eb8fb0

100.

Rubinstein A, Pathak YV, Kleinstern J, Reches A, Benita S. In vitro release and intestinal absorption of physostigmine salicylate from submicron emulsions. Journal of Pharmaceutical Sciences [Internet]. 1991;80(7):643–7. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025743979&doi=10.1002%252fjps.2600800706&partnerID=40&md5=6d5f919f146dd48bdab4269b22a27502

101.

Pathak YV, Rubinstein A, Benita S. Enhanced stability of physostigmine salicylate in submicron o/w emulsion. International Journal of Pharmaceutics [Internet]. 1990;65(3):169–75. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025674387&doi=10.1016%2f0378-5173%2890%2990140-Y&partnerID=40&md5=db996409d505def01b2bc0373515686e

102.

Rubinstein A. Microbially controlled drug delivery to the colon. Biopharmaceutics & Drug Disposition [Internet]. 1990;11(6):465–75. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025050623&doi=10.1002%252fbdd.2510110602&partnerID=40&md5=c4be0ffab0e031a5cd8bdd306a21e66a

103.

Rubinstein A, Li VHK, Gruber P, Bass P, Robinson JR. Improved intestinal cannula for drug delivery studies in the dog. Journal of Pharmacological Methods [Internet]. 1988;19(3):213–7. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023880449&doi=10.1016%2f0160-5402%2888%2990023-X&partnerID=40&md5=946972e64fb82012ce9b4d1916d0455d

104.

Gruber P, Rubinstein A, Li VHK, Bass P, Robinson JR. Gastric emptying of nondigestible solids in the fasted dog. Journal of Pharmaceutical Sciences [Internet]. 1987;76(2):117–22. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023283990&doi=10.1002%252fjps.2600760207&partnerID=40&md5=f224991e743d8b48e605f9bc436f885c

105.

Rubinstein A, Gonen A, Friedman M. Computerized model for evaluating the kinetics of in vitro release of valpromide from controlled‐release tablets under nonsink conditions. Journal of Pharmaceutical Sciences [Internet]. 1986;75(10):959–61. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022975261&doi=10.1002%252fjps.2600751010&partnerID=40&md5=99f8ce86ea1cfbf78517c1d352e507aa

106.

Rubinstein A, Bialer M, Friedman M, Raz I, Abramsky O. A combined approach to control valproic acid release via novel delivery system of valpromide: A kinetic and pharmacokinetic study. Journal of Controlled Release [Internet]. 1986;4(1):33–8. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022919305&doi=10.1016%2f0168-3659%2886%2990031-3&partnerID=40&md5=21254980aa13ff758edf191b7c24afbe

107.

Bialer M, Rubinstein A, Dubrovsky J, Raz I, Abramsky O. A comparative pharmacokinetic study of valpromide and valproic acid after intravenous administration in humans. International Journal of Pharmaceutics [Internet]. 1985;23(1):25–33. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021948924&doi=10.1016%2f0378-5173%2885%2990219-4&partnerID=40&md5=85a7d16acc8f3c1650bd38383d217eb4

108.

Bialer M, Rubinstein A, Raz I, Abramsky O. Pharmacokinetics of valpromide after oral administration of a solution and a tablet to healthy volunteers. European Journal of Clinical Pharmacology [Internet]. 1984;27(4):501–3. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021677679&doi=10.1007%252fBF00549603&partnerID=40&md5=a19fbd0c93bbc7434738c2b07e428d2a

109.

Bialer M, Friedman M, Rubinstein A. Rapid gas chromatographic assay for monitoring valproic acid and valpromide in plasma. Journal of Pharmaceutical Sciences [Internet]. 1984;73(7):991–3. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021270970&doi=10.1002%252fjps.2600730734&partnerID=40&md5=54b9b43e246d537b78d672e7021e5825

110.

Bialer M, Rubinstein A. Pharmacokinetics of valpromide in dogs after various modes of administration. Biopharmaceutics & Drug Disposition [Internet]. 1984;5(2):177–83. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021260414&doi=10.1002%252fbdd.2510050211&partnerID=40&md5=1c1b7bce9aaffe67b8266621831e7add

111.

Bialer M, Rubinstein A. A comparative study on the pharmacokinetics of valpramide after intravenous administration in dogs. Journal of Pharmacy and Pharmacology [Internet]. 1983;35(9):607–9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0020604494&doi=10.1111%252fj.2042-7158.1983.tb04347.x&partnerID=40&md5=a126f23712d1178a13763d08f3fd22b7

112.

Garti N, Magdassi S, Rubinstein A. A novel method for rapid non destructive determination of o/w creams stability. Drug Development and Industrial Pharmacy [Internet]. 1982;8(4):475–85. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0007327614&doi=10.3109%252f03639048209022115&partnerID=40&md5=fac979efddb941b0044dbc58e45de9d2

113.

Garti N, Magdasi S, Rubinstein A. A new method for stability determination of semi-solid emulsions, using conductivity measurements. Colloids and Surfaces [Internet]. 1981;3(3):221–31. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0019637252&doi=10.1016%2f0166-6622%2881%2980039-X&partnerID=40&md5=e122e85c4ba11f41f64333d394793258