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School of Pharmacy : Shohami Esther


 Last updated February 2023 - School of Pharmacy

List of Publications

(1) Weisinger B, Pandey DP, Saver JL, Hochberg A, Bitton A, Doniger GM, et al. Frequency-tuned electromagnetic field therapy improves post-stroke motor function: A pilot randomized controlled trial. Front Neurol 2022;13.

(2) Liraz-Zaltsman S, Friedman-Levi Y, Shabashov-Stone D, Gincberg G, Atrakcy-Baranes D, Joy MT, et al. Chemokine Receptors CC Chemokine Receptor 5 and C-X-C Motif Chemokine Receptor 4 Are New Therapeutic Targets for Brain Recovery after Traumatic Brain Injury. J Neurotrauma 2021;38(14):2003-2017.

(3) Friedman-Levi Y, Liraz-Zaltsman S, Shemesh C, Rosenblatt K, Kesner EL, Gincberg G, et al. Pharmacological blockers of CCR5 and CXCR4 improve recovery after traumatic brain injury. Exp Neurol 2021;338.

(4) Fleischmann C, Shohami E, Trembovler V, Heled Y, Horowitz M. Cognitive Effects of Astaxanthin Pretreatment on Recovery From Traumatic Brain Injury. Front Neurol 2020;11.

(5) Magid L, Heymann S, Elgali M, Avram L, Cohen Y, Liraz-Zaltsman S, et al. Role of CB2 Receptor in the Recovery of Mice after Traumatic Brain Injury. J Neurotrauma 2019;36(11):1836-1846.

(6) Joy MT, Ben Assayag E, Shabashov-Stone D, Liraz-Zaltsman S, Mazzitelli J, Arenas M, et al. CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury. Cell 2019;176(5):1143-1157.e13.

(7) Liraz-Zaltsman S, Slusher B, Atrakchi-Baranes D, Rosenblatt K, Friedman Levi Y, Kesner E, et al. Enhancement of Brain d-Serine Mediates Recovery of Cognitive Function after Traumatic Brain Injury. J Neurotrauma 2018;35(14):1667-1680.

(8) Gincberg G, Shohami E, Trembovler V, Alexandrovich AG, Lazarovici P, Elchalal U. Nerve growth factor plays a role in the neurotherapeutic effect of a CD45 + pan-hematopoietic subpopulation derived from human umbilical cord blood in a traumatic brain injury model. Cytotherapy 2018;20(2):245-261.

(9) Gincberg G, Shohami E, Lazarovici P, Elchalal U. Human Umbilical Cord Blood CD45+ Pan-Hematopoietic Cells Induced a Neurotherapeutic Effect in Mice with Traumatic Brain Injury: Immunophenotyping, Comparison of Maternal and Neonatal Parameters, and Immunomodulation. J Mol Neurosci 2018;64(2):185-199.

(10) Biegon A, Liraz-Zaltsman S, Shohami E. Stimulation of N-methyl-D-aspartate receptors by exogenous and endogenous ligands improves outcome of brain injury. Curr Opin Neurol 2018;31(6):687-692.

(11) Liraz-Zaltsman S, Yaka R, Shabashov D, Shohami E, Biegon A. Neuroinflammation-Induced Memory Deficits Are Amenable to Treatment with d-Cycloserine. J Mol Neurosci 2016;60(1):46-62.

(12) Mann A, Cohen-Yeshurun A, Trembovler V, Mechoulam R, Shohami E. Are the endocannabinoid-like compounds N-acyl aminoacids neuroprotective after traumatic brain injury? J Basic Clin Physiol Pharmacol 2016;27(3):209-216.

(13) Shohami E, Horowitz M. Cannabinoids in Health and Disease. J Basic Clin Physiol Pharmacol 2016;27(3):175-179.

(14) Umschweif G, Shein NA, Alexandrovich AG, Trembovler V, Horowitz M, Shohami E. Erratum : Heat acclimation provides sustained improvement in functional recovery and attenuates apoptosis after traumatic brain injury (Journal of Cerebral Blood Flow and Metabolism (2010) 30, (616-627)) DOI:10.1038/jcbfm.2009.234). J Cereb Blood Flow Metab 2015;35(11):1301.

(15) Mann A, Smoum R, Trembovler V, Alexandrovich A, Breuer A, Mechoulam R, et al. Palmitoyl Serine: An Endogenous Neuroprotective Endocannabinoid-Like Entity After Traumatic Brain Injury. J Neuroimmune Pharmacol 2015;10(2):356-363.

(16) Horowitz M, Umschweif G, Yacobi A, Shohami E. Molecular programs induced by heat acclimation confer neuroprotection against TBI and hypoxic insults via cross-tolerance mechanisms. Front Neurosci 2015;9(JUL).

(17) Dvela-Levitt M, Ami HC-, Rosen H, Shohami E, Lichtstein D. Ouabain improves functional recovery following traumatic brain injury. J Neurotrauma 2014;31(23):1942-1947.

(18) Arien-Zakay H, Gincberg G, Nagler A, Cohen G, Liraz-Zaltsman S, Trembovler V, et al. Neurotherapeutic effect of cord blood derived CD45+ hematopoietic cells in mice after traumatic brain injury. J Neurotrauma 2014;31(16):1405-1416.

(19) Willner D, Cohen-Yeshurun A, Avidan A, Ozersky V, Shohami E, Leker RR. Short term morphine exposure in vitro alters proliferation and differentiation of neural progenitor cells and promotes apoptosis via Mu receptors. PLoS ONE 2014;9(7).

(20) Dachir S, Shabashov D, Trembovler V, Alexandrovich AG, Benowitz LI, Shohami E. Inosine improves functional recovery after experimental traumatic brain injury. Brain Res 2014;1555:78-88.

(21) Hanuš L, Shohami E, Bab I, Mechoulam R. N-Acyl amino acids and their impact on biological processes. Biofactors 2014;40(4):381-388.

(22) Umschweif G, Liraz-Zaltsman S, Shabashov D, Alexandrovich A, Trembovler V, Horowitz M, et al. Angiotensin Receptor Type 2 Activation Induces Neuroprotection and Neurogenesis After Traumatic Brain Injury. Neurotherapeutics 2014;11(3):665-678.

(23) Umschweif G, Shabashov D, Alexandrovich AG, Trembovler V, Horowitz M, Shohami E. Neuroprotection after traumatic brain injury in heat-acclimated mice involves induced neurogenesis and activation of angiotensin receptor type 2 signaling. J Cereb Blood Flow Metab 2014;34(8):1381-1390.

(24) Shohami E, Biegon A. Novel approach to the role of NMDA receptors in traumatic brain injury. CNS Neurol Disord Drug Targets 2014;13(4):567-573.

(25) Umschweif G, Alexandrovich AG, Trembovler V, Horowitz M, Shohami E. The Role and Dynamics of β-Catenin in Precondition Induced Neuroprotection after Traumatic Brain Injury. PLoS ONE 2013;8(10).

(26) Mechoulam R, Shohami E. HU-211: A cannabinoid neuroprotective agent. Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential; 2013. p. 389-398.

(27) Cohen-Yeshurun A, Willner D, Trembovler V, Alexandrovich A, Mechoulam R, Shohami E, et al. N-arachidonoyl-L-serine (AraS) possesses proneurogenic properties in vitro and in vivo after traumatic brain injury. J Cereb Blood Flow Metab 2013;33(8):1242-1250.

(28) Umschweif G, Alexandrovich AG, Trembovler V, Horowitz M, Shohami E. Hypoxia-inducible factor 1 is essential for spontaneous recovery from traumatic brain injury and is a key mediator of heat acclimation induced neuroprotection. J Cereb Blood Flow Metab 2013;33(4):524-531.

(29) Shohami E, Horowitz M. Intrinsic neuroprotection in traumatic brain injury. Innate Tolerance in the CNS: Translational Neuroprotection by Pre- and Post-Conditioning; 2013. p. 499-519.

(30) Peters M, Trembovler V, Alexandrovich A, Parnas M, Birnbaumer L, Minke B, et al. Carvacrol together with TRPC1 elimination improve functional recovery after traumatic brain injury in mice. J Neurotrauma 2012;29(18):2831-2834.

(31) Shabashov D, Shohami E, Yaka R. Inactivation of PKMζ in the NAc shell abolished cocaine-conditioned reward. J Mol Neurosci 2012;47(3):546-553.

(32) Thau-Zuchman O, Shohami E, Alexandrovich AG, Leker RR. Combination of vascular endothelial and fibroblast growth factor 2 for induction of neurogenesis and angiogenesis after traumatic brain injury. J Mol Neurosci 2012;47(1):166-172.

(33) Moussaieff A, Yu J, Zhu H, Gattoni-Celli S, Shohami E, Kindy MS. Protective effects of incensole acetate on cerebral ischemic injury. Brain Res 2012;1443:89-97.

(34) Thau-Zuchman O, Shohami E, Alexandrovich AG, Leker RR. Subacute treatment with vascular endothelial growth factor after traumatic brain injury increases angiogenesis and gliogenesis. Neuroscience 2012;202:334-341.

(35) Oron A, Oron U, Streeter J, De Taboada L, Alexandrovich A, Trembovler V, et al. Near infrared transcranial laser therapy applied at various modes to mice following traumatic brain injury significantly reduces long-term neurological deficits. J Neurotrauma 2012;29(2):401-407.

(36) Thau-Zuchman O, Shohami E, Alexandrovich AG, Trembovler V, Leker RR. The anti-inflammatory drug carprofen improves long-term outcome and induces gliogenesis after traumatic brain injury. J Neurotrauma 2012;29(2):375-384.

(37) Shohami E, Cohen-Yeshurun A, Magid L, Algali M, Mechoulam R. Endocannabinoids and traumatic brain injury. Br J Pharmacol 2011;163(7):1402-1410.

(38) Liraz-Zaltsman S, Alexandrovich AG, Trembovler V, Fishbein I, Yaka R, Shohami E, et al. Regional sensitivity to neuroinflammation: In vivo and in vitro studies. Synapse 2011;65(7):634-642.

(39) Lourbopoulos A, Grigoriadis N, Lagoudaki R, Touloumi O, Polyzoidou E, Mavromatis I, et al. Administration of 2-arachidonoylglycerol ameliorates both acute and chronic experimental autoimmune encephalomyelitis. Brain Res 2011;1390:126-141.

(40) Shein NA, Shohami E. Histone deacetylase inhibitors as therapeutic agents for acute central nervous system injuries. Mol Med 2011;17(5-6):448-456.

(41) Ofek O, Attar-Namdar M, Kram V, Dvir-Ginzberg M, Mechoulam R, Zimmer A, et al. CB2 cannabinoid receptor targets mitogenic Gi protein-cyclin D1 axis in osteoblasts. J Bone Miner Res 2011;26(2):308-316.

(42) Cohen-Yeshurun A, Trembovler V, Alexandrovich A, Ryberg E, Greasley PJ, Mechoulam R, et al. N-arachidonoyl-L-serine is neuroprotective after traumatic brain injury by reducing apoptosis. J Cereb Blood Flow Metab 2011;31(8):1768-1777.

(43) Thau-Zuchman O, Shohami E, Alexandrovich AG, Leker RR. Vascular endothelial growth factor increases neurogenesis after traumatic brain injury. J Cereb Blood Flow Metab 2010;30(5):1008-1016.

(44) Adeleye A, Shohami E, Nachman D, Alexandrovich A, Trembovler V, Yaka R, et al. d-Cycloserine improves functional outcome after traumatic brain injury with wide therapeutic window. Eur J Pharmacol 2010;629(1-3):25-30.

(45) Umschwief G, Shein NA, Alexandrovich AG, Trembovler V, Horowitz M, Shohami E. Heat acclimation provides sustained improvement in functional recovery and attenuates apoptosis after traumatic brain injury. J Cereb Blood Flow Metab 2010;30(3):616-627.

(46) Horowitz M, Shohami E. Environmental Stress is Not Always Vicious: A Lesson from Heat Acclimation-Mediated Neuroprotection after Traumatic Brain Injury. Stress - From Molecules to Behavior: A Comprehensive Analysis of the Neurobiology of Stress Responses; 2009. p. 349-364.

(47) Shein NA, Grigoriadis N, Alexandrovich AG, Simeonidou C, Lourbopoulos A, Polyzoidou E, et al. Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury. FASEB J 2009;23(12):4266-4275.

(48) Flierl MA, Stahel PF, Beauchamp KM, Morgan SJ, Smith WR, Shohami E. Mouse closed head injury model induced by a weight-drop device. Nat Protoc 2009;4(9):1328-1337.

(49) Levy A, Bercovich-Kinori A, Alexandrovich AG, Tsenter J, Trembovler V, Lund FE, et al. CD38 facilitates recovery from traumatic brain injury. J Neurotrauma 2009;26(9):1521-1533.

(50) Shein NA, Grigoriadis N, Horowitz M, Umschwief G, Alexandrovich AG, Simeonidou C, et al. Microglial involvement in neuroprotection following experimental traumatic brain injury in heat-acclimated mice. Brain Res 2008;1244:132-141.

(51) Beauchamp K, Mutlak H, Smith WR, Shohami E, Stahel PF. Pharmacology of traumatic brain injury: Where is the "golden bullet"? Mol Med 2008;14(11-12):731-740.

(52) Moussaieff A, Rimmerman N, Bregman T, Straiker A, Felder CC, Shoham S, et al. Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain. FASEB J 2008;22(8):3024-3034.

(53) Moussaieff A, Shein NA, Tsenter J, Grigoriadis S, Simeonidou C, Alexandrovich AG, et al. Incensole acetate: A novel neuroprotective agent isolated from Boswellia carterii. J Cereb Blood Flow Metab 2008;28(7):1341-1352.

(54) Reshef A, Shirvan A, Shohami E, Grimberg H, Levin G, Cohen A, et al. Targeting cell death in vivo in experimental traumatic brain injury by a novel molecular probe. J Neurotrauma 2008;25(6):569-580.

(55) Nadler Y, Alexandrovich A, Grigoriadis N, Hartmann T, Jagannatha Rao KS, Shohami E, et al. Increased expression of the γ-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury. Glia 2008;56(5):552-567.

(56) Tsenter J, Beni-Adani L, Assaf Y, Alexandrovich AG, Trembovler V, Shohami E. Dynamic changes in the recovery after traumatic brain injury in mice: Effect of injury severity on T2-weighted MRI abnormalities, and motor and cognitive functions. J Neurotrauma 2008;25(4):324-333.

(57) Shein NA, Grigoriadis N, Alexandrovich AG, Simeonidou C, Spandou E, Tsenter J, et al. Differential neuroprotective properties of endogenous and exogenous erythropoietin in a mouse model of traumatic brain injury. J Neurotrauma 2008;25(2):112-123.

(58) Tam J, Trembovler V, Di Marzo V, Petrosino S, Leo G, Alexandrovich A, et al. The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling. FASEB J 2008;22(1):285-294.

(59) Shein NA, Doron H, Horowitz M, Trembovler V, Alexandrovich AG, Shohami E. Altered cytokine expression and sustained hypothermia following traumatic brain injury in heat acclimated mice. Brain Res 2007;1185(1):313-320.

(60) Moussaieff A, Shohami E, Kashman Y, Fride E, Schmitz ML, Renner F, et al. Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-κB activation. Mol Pharmacol 2007;72(6):1657-1664.

(61) Shein NA, Tsenter J, Alexandrovich AG, Horowitz M, Shohami E. Akt phosphorylation is required for heat acclimation-induced neuroprotection. J Neurochem 2007;103(4):1523-1529.

(62) Marciano D, Shohami E, Kloog Y, Alexandrovitch A, Brandeis R, Goelman G. Neuroprotective effects of the Ras inhibitor s-trans-trans- farnesylthiosalicylic acid, measured by diffusion-weighted imaging after traumatic brain injury in rats. J Neurotrauma 2007;24(8):1378-1386.

(63) Shein NA, Horowitz M, Shohami E. Heat acclimation: a unique model of physiologically mediated global preconditioning against traumatic brain injury. Prog Brain Res 2007;161:353-363.

(64) Yaka R, Biegon A, Grigoriadis N, Simeonidou C, Grigoriadis S, Alexandrovich AG, et al. D-cycloserine improves functional recovery and reinstates long-term potentiation (LTP) in a mouse model of closed head injury. FASEB J 2007;21(9):2033-2041.

(65) Oron A, Oron U, Streeter J, De Taboada L, Alexandrovich A, Trembovler V, et al. Low-level laser therapy applied transcranially to mice following traumatic brain injury significantly reduces long-term neurological deficits. J Neurotrauma 2007;24(4):651-656.

(66) Shapira M, Licht A, Milman A, Pick CG, Shohami E, Eldar-Finkelman H. Role of glycogen synthase kinase-3β  in early depressive behavior induced by mild traumatic brain injury. Mol Cell Neurosci 2007;34(4):571-577.

(67) Erlich S, Alexandrovich A, Shohami E, Pinkas-Kramarski R. Rapamycin is a neuroprotective treatment for traumatic brain injury. Neurobiol Dis 2007;26(1):86-93.

(68) Mechoulam R, Shohami E. Endocannabinoids and traumatic brain injury. Mol Neurobiol 2007;36(1):68-74.

(69) Grosjean MB, Lenzlinger PM, Stahel PF, Yatsiv I, Shohami E, Trentz O, et al. Immunohistochemical characterization of Fas (CD95) and Fas Ligand (FasL/CD95L) expression in the injured brain: Relationship with neuronal cell death and inflammatory mediators. Histol Histopathol 2007;22(1-3):235-250.

(70) Yirmiya R, Goshen I, Bajayo A, Kreisel T, Feldman S, Tam J, et al. Depression induces bone loss through stimulation of the sympathetic nervous system. Proc Natl Acad Sci U S A 2006;103(45):16876-16881.

(71) Mccarron RM, Chen Y, Tomori T, Strasser A, Mechoulam R, Shohami E, et al. Endothelial-mediated regulation of cerebral microcirculation. J Physiol Pharmacol 2006;57(SUPPL. 11):133-144.

(72) Panikashvili D, Shein NA, Mechoulam R, Trembovler V, Kohen R, Alexandrovich A, et al. The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines. Neurobiol Dis 2006;22(2):257-264.

(73) Shohami E, Mechoutam R. Multiple sclerosis may disrupt endocannabinoid brain protection mechanism. Proc Natl Acad Sci U S A 2006;103(16):6087-6088.

(74) Beni SM, Tsenter J, Alexandrovich AG, Galron-Krool N, Barzilai A, Kohen R, et al. CuZn-SOD deficiency, rather than overexpression, is associated with enhanced recovery and attenuated activation of NF-κB after brain trauma in mice. J Cereb Blood Flow Metab 2006;26(4):478-490.

(75) Moor E, Shohami E, Kanevsky E, Grigoriadis N, Symeonidou C, Kohen R. Impairment of the ability of the injured aged brain in elevating urate and ascorbate. Exp Gerontol 2006;41(3):303-311.

(76) Ofek O, Karsak M, Leclerc N, Fogel M, Frenkel B, Wright K, et al. Peripheral cannabinoid receptor, CB2, regulates bone mass. Proc Natl Acad Sci U S A 2006;103(3):696-701.

(77) Tam J, Ofek O, Fride E, Ledent C, Gabet Y, M̈uller R, et al. Involvement of neuronal cannabinoid receptor CB1 in regulation of bone mass and bone remodeling. Mol Pharmacol 2006;70(3):786-792.

(78) Erlich S, Shohami E, Pinkas-Kramarski R. Neurodegeneration induces upregulation of Beclin 1. Autophagy 2006;2(1):49-51.

(79) Shein NA, Horowitz M, Alexandrovich AG, Tsenter J, Shohami E. Heat acclimation increases hypoxia-inducible factor 1α and erythropoietin receptor expression: Implication for neuroprotection after closed head injury in mice. J Cereb Blood Flow Metab 2005;25(11):1456-1465.

(80) Yatsiv I, Grigoriadis N, Simeonidou C, Stahel PF, Schmidt OI, Alexandrovitch AG, et al. Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury. FASEB J 2005;19(12):1701-1703.

(81) Bajayo A, Goshen I, Feldman S, Csernus V, Iverfeldt K, Shohami E, et al. Central IL-1 receptor signaling regulates bone growth and mass. Proc Natl Acad Sci U S A 2005;102(36):12956-12961.

(82) Zaltzman R, Alexandrovich A, Trembovler V, Shohami E, Gozes I. The influence of the peptide NAP on Mac-1-deficient mice following closed head injury. Peptides 2005;26(8):1520-1527.

(83) Diskin T, Tal-Or P, Erlich S, Mizrachy L, Alexandrovich A, Shohami E, et al. Closed head injury induces upregulation of beclin 1 at the cortical site of injury. J Neurotrauma 2005;22(7):750-762.

(84) Gozes I, Zaltzman R, Hauser J, Brenneman DE, Shohami E, Hill JM. The expression of activity-dependent neuroprotective protein (ADNP) is regulated by brain damage and treatment of mice with the ADNP derived peptide, NAP, reduces the severity of traumatic head injury. Curr Alzheimer Res 2005;2(2):149-153.

(85) Panikashvili D, Mechoulam R, Beni SM, Alexandrovich A, Shohami E. CB1 cannabinoid receptors are involved in neuroprotection via NF-κB inhibition. J Cereb Blood Flow Metab 2005;25(4):477-484.

(86) Gopez JJ, Yue H, Vasudevan R, Malik AS, Fogelsanger LN, Lewis S, et al. Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury. Neurosurgery 2005;56(3):590-603.

(87) Glantz L, Avramovich A, Trembovler V, Gurvitz V, Kohen R, Eidelman LA, et al. Ischemic preconditioning increases antioxidants in the brain and peripheral organs after cerebral ischemia. Exp Neurol 2005;192(1):117-124.

(88) Golech SA, McCarron RM, Chen Y, Bembry J, Lenz F, Mechoulam R, et al. Human brain endothelium: Coexpression and function of vanilloid and endocannabinoid receptors. Mol Brain Res 2004;132(1):87-92.

(89) Zaltzman R, Alexandrovich A, Beni SM, Trembovler V, Shohami E, Gozes I. Brain injury-dependent expression of activity-dependent neuroprotective protein. J Mol Neurosci 2004;24(2):181-187.

(90) Schmidt OI, Morganti-Kossmann MC, Heyde CE, Perez D, Yatsiv I, Shohami E, et al. Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: A clinical and experimental study in head-injured patients and in a murine model of closed head injury. J Neuroinflamm 2004;1.

(91) Biegon A, Fry PA, Paden CM, Alexandrovich A, Tsenter J, Shohami E. Dynamic changes in N-methyl-D-aspartate receptors after closed head injury in mice: Implications for treatment of neurological and cognitive deficits. Proc Natl Acad Sci U S A 2004;101(14):5117-5122.

(92) Beni SM, Kohen R, Reiter RJ, Tan DX, Shohami E. Melatonin-induced neuroprotection after closed head injury is associated with increased brain antioxidants and attenuated late-phase activation of NF-kappaB and AP-1. FASEB J 2004;18(1):149-151.

(93) Paschen W, Yatsiv I, Shoham S, Shohami E. Brain trauma induces X-box protein 1 processing indicative of activation of the endoplasmic reticulum unfolded protein response. J Neurochem 2004;88(4):983-992.

(94) Trembovler V, Abu-Raya S, Shohami E. Synergism between tumor necrosis factor-α and H2O 2 enhances cell damage in rat PC12 cells. Neurosci Lett 2003;353(2):115-118.

(95) Ezra Y, Oron L, Moskovich L, Roses AD, Beni SM, Shohami E, et al. Apolipoprotein E4 decreases whereas apolipoprotein E3 increases the level of secreted amyloid precursor protein after closed head injury. Neuroscience 2003;121(2):315-325.

(96) Shohami E, Yatsiv I, Alexandrovich A, Haklai R, Elad-Sfadia G, Grossman R, et al. The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model. J Cereb Blood Flow Metab 2003;23(6):728-738.

(97) Kipnis J, Nevo U, Panikashvili D, Alexandrovich A, Yoles E, Akselrod S, et al. Therapeutic vaccination for closed head injury. J Neurotrauma 2003;20(6):559-569.

(98) Zaltzman R, Beni SM, Giladi E, Pinhasov A, Steingart RA, Romano J, et al. Injections of the neuroprotective peptide NAP to newborn mice attenuate head-injury-related dysfunction in adults. Neuroreport 2003;14(3):481-484.

(99) Spatz M, McCarron RM, Shohami E, Panikashvili D, Chen Y, Golcch S, et al. Antioxidant properties of the vasoactive endocannabinoid, 2-arachidonoyl glycerol (2-AG). Acta Neurochir Suppl 2003(86):271-275.

(100) Grossman R, Shohami E, Alexandrovich A, Yatsiv I, Kloog Y, Biegon A. Increase in peripheral benzodiazepine receptors and loss of glutamate NMDA receptors in a mouse model of closed head injury: A quantitative autoradiographic study. Neuroimage 2003;20(4):1971-1981.

(101) Spielman L, Winger D, Ho L, Aisen PS, Shohami E, Pasinetti GM. Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2. Acta Neuropathol 2002;103(2):157-162.

(102) Fride E, Shohami E. The endocannabinoid system: Function in survival of the embryo, the newborn and the neuron. Neuroreport 2002;13(15):1833-1841.

(103) Leker RR, Shohami E. Cerebral ischemia and trauma - Different etiologies yet similar mechanisms: Neuroprotective opportunities. Brain Res Rev 2002;39(1):55-73.

(104) Ivanova S, Batliwalla F, Mocco J, Kiss S, Huang J, Mack W, et al. Neuroprotection in cerebral ischemia by neutralization of 3-aminopropanal. Proc Natl Acad Sci U S A 2002;99(8):5579-5584.

(105) Mechoulam R, Spatz M, Shohami E. Endocannabinoids and neuroprotection. Sci STKE 2002;2002(129).

(106) Tehranian R, Andell-Jonsson S, Beni SM, Yatsiv I, Shohami E, Bartfai T, et al. Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist. J Neurotrauma 2002;19(8):939-951.

(107) Leker RR, Teichner A, Lavie G, Shohami E, Lamensdorf I, Ovadia H. The nitroxide antioxidant tempol is cerebroprotective against focal cerebral ischemia in spontaneously hypertensive rats. Exp Neurol 2002;176(2):355-363.

(108) Yatsiv I, Morganti-Kossmann MC, Perez D, Dinarello CA, Novick D, Rubinstein M, et al. Elevated intracranial IL-18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL-18-binding protein after experimental closed head injury. J Cereb Blood Flow Metab 2002;22(8):971-978.

(109) Romano J, Beni-Adani L, Nissenbaum OL, Brenneman DE, Shohami E, Gozes I. A single administration of the peptide NAP induces long-term protective changes against the consequences of head injury: Gene Atlas array analysis. J Mol Neurosci 2002;18(1-2):37-45.

(110) Mechoulam R, Panikashvili D, Shohami E. Cannabinoids and brain injury: Therapeutic implications. Trends Mol Med 2002;8(2):58-61.

(111) Leker RR, Shohami E, Constantini S. Experimental models of head trauma. Acta Neurochir Suppl 2002(83):49-54.

(112) Moor E, Kohen R, Reiter RJ, Shohami E. Closed head injury increases extracellular levels of antioxidants in rat hippocampus in vivo: An adaptive mechanism? Neurosci Lett 2001;316(3):169-172.

(113) Stahel PP, Yatsiv I, Morganti-Kossmann MC, Ferez D, Novick D, Rubinstein M, et al. Elevated intracranial il-18 and evidence of neuroprotective effects of IL-18 binding protein (IL-18bp) after experimental closed head injury. Langenbeck's Arch Surg 2001;386(6):474-475.

(114) Panikashvili D, Simeonidou C, Ben-Shabat S, Hanuš L, Breuer A, Mechoulam R, et al. An endogenous cannabinoid (2-AG) is neuroprotective after brain injury. Nature 2001;413(6855):527-531.

(115) Otto VI, Stahel PF, Rancan M, Kariya K, Shohami E, Yatsiv I, et al. Regulation of chemokines and chemokine receptors after experimental closed head injury. Neuroreport 2001;12(9):2059-2064.

(116) Lavie G, Teichner A, Shohami E, Ovadia H, Leker RR. Long term cerebroprotective effects of dexanabinol in a model of focal cerebral ischemia. Brain Res 2001;901(1-2):195-201.

(117) Barzillai R, Shani J, Katzir I, Shohami E, Trembovler V, Hristekieva E, et al. Serum vasoactive prostaglandins; TNFα and magnesium, in hypertensive psoriatics undergoing climatotherapy at the Dead-Sea. Pharmacol Rev Commun 2001;11(2):131-141.

(118) Zhao X, Bausano B, Pike BR, Newcomb-Fernandez JK, Wang KKW, Shohami E, et al. TNF-α stimulates caspase-3 activation and apoptotic cell death in primary septo-hippocampal cultures. J Neurosci Res 2001;64(2):121-131.

(119) Beni-Adani L, Gozes I, Cohen Y, Assaf Y, Steingart RA, Brenneman DE, et al. A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice. J Pharmacol Exp Ther 2001;296(1):57-63.

(120) Tan DX, Manchester LC, Burkhardt S, Sainz RM, Mayo JC, Kohen R, et al. N1-acetyl-N2-formyl-5-methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant. FASEB J 2001;15(12):2294-2296.

(121) Mautes AEM, Thome D, Steudel W-, Nacimiento AC, Yang Y, Shohami E. Changes in regional energy metabolism after closed head injury in the rat. J Mol Neurosci 2001;16(1):33-39.

(122) Sabo T, Lomnitski L, Nyska A, Beni S, Maronpot RR, Shohami E, et al. Susceptibility of transgenic mice expressing human apolipoprotein E to closed head injury: The allele E3 is neuroprotective whereas E4 increases fatalities. Neuroscience 2000;101(4):879-884.

(123) Stahel PF, Kariya K, Shohami E, Barnum SR, Eugster H-, Trentz O, et al. Intracerebral complement C5a receptor (CD88) expression is regulated by TNF and lymphotoxin-α following closed head injury in mice. J Neuroimmunol 2000;109(2):164-172.

(124) Chen Y, McCarron RM, Ohara Y, Bembry J, Azzam N, Lenz FA, et al. Human brain capillary endothelium: 2-Arachidonoglycerol (endocannabinoid) interacts with endothelin-1. Circ Res 2000;87(4):323-327.

(125) Genis L, Chen Y, Shohami E, Michaelson DM. Tau hyperphosphorylation in apolipoprotein E-deficient and control mice after closed head injury. J Neurosci Res 2000;60(4):559-564.

(126) Stahel PF, Shohami E, Younis FM, Kariya K, Otto VI, Lenzlinger PM, et al. Experimental closed head injury: Analysis of neurological outcome, blood-brain barrier dysfunction, intracranial neutrophil infiltration, and neuronal cell death in mice deficient in genes for pro-inflammatory cytokines. J Cereb Blood Flow Metab 2000;20(2):369-380.

(127) Ginis I, Hallenbeck JM, Liu J, Spatz M, Jaiswal R, Shohami E. Tumor necrosis factor and reactive oxygen species cooperative cytotoxicity is mediated via inhibition of NF-kappaB. Mol Med 2000;6(12):1028-1041.

(128) Erlich S, Shohami E, Pinkas-Kramarski R. Closed head injury induces up-regulation of ErbB-4 receptor at the site of injury. Mol Cell Neurosci 2000;16(5):597-608.

(129) Lomnitski L, Nyska A, Shohami E, Chen Y, Michaelson DM. Increased levels of intracellular iron in the brains of ApoE-deficient mice with closed head injury. Exp Toxicol Pathol 2000;52(2):177-183.

(130) Elangovan V, Shohami E, Gati I, Kohen R. Increased hepatic lipid soluble antioxidant capacity as compared to other organs of streptozotocin-induced diabetic rats: A cyclic voltammetry study. Free Radic Res 2000;32(2):125-134.

(131) Morecki S, Yacovlev E, Gelfand Y, Trembovler V, Shohami E, Slavin S. Induction of antitumor immunity by indomethacin. Cancer Immunol Immunother 2000;48(11):613-620.

(132) Shohami E, Kaufer D, Chen Y, Seidman S, Cohen O, Ginzberg D, et al. Antisense prevention of neuronal damages following head injury in mice. J Mol Med 2000;78(4):228-236.

(133) Shohami E, Mechoulam R. Dexanabinol (HU-211): A nonpsychotropic cannabinoid with neuroprotective properties. Drug Dev Res 2000;50(3-4):211-215.

(134) Elangovan V, Kohen R, Shohami E. Neurological recovery from closed head injury is impaired in diabetic rats. J Neurotrauma 2000;17(11):1013-1027.

(135) Barone FC, Ohlstein EH, Hunter AJ, Campbell CA, Hadingham SH, Parsons AA, et al. Selective antagonism of endothelin-A-receptors improves outcome in both head trauma and focal stroke in rat. J Cardiovasc Pharmacol 2000;36(5 SUPPL. 1):S357-S361.

(136) Abu-Raya S, Blaugrund E, Trembovler V, Shilderman-Bloch E, Shohami E, Lazarovici P. Rasagiline, a monoamine oxidase-B inhibitor, protects NGF-differentiated PC12 cells against oxygen-glucose deprivation. J Neurosci Res 1999;58(3):456-463.

(137) Trembovler V, Beit-Vannai E, Younis F, Gallily R, Horowitz M, Shohami E. Antioxidants attenuate acute toxicity of tumor necrosis factor-α induced by brain injury in rat. J Interferon Cytokine Res 1999;19(7):791-795.

(138) Klein BY, Shohami E, Reikhinshtein Y, Ben-Bassat H, Liebergall M. Serum-mediated osteogenic effects of head injury on cultured rat marrow stromal cells. Calcif Tissue Int 1999;65(3):217-222.

(139) Lomnitski L, Chapman S, Hochman A, Kohen R, Shohami E, Chen Y, et al. Antioxidant mechanisms in apolipoprotein E deficient mice prior to and following closed head injury. Biochim Biophys Acta Mol Basis Dis 1999;1453(3):359-368.

(140) Huang W, Chen Y, Shohami E, Weinstock M. Neuroprotective effect of rasagiline, a selective monoamine oxidase-B inhibitor, against closed head injury in the mouse. Eur J Pharmacol 1999;366(2-3):127-135.

(141) Abu-Raya S, Bloch-Shilderman E, Lelkes PI, Trembovler V, Shohami E, Gutman Y, et al. Characterization of pardaxin-induced dopamine release from pheochromocytoma cells: Role of calcium and eicosanoids. J Pharmacol Exp Ther 1999;288(2):399-406.

(142) Leker RR, Shohami E, Abramsky O, Ovadia H. Dexanabinol; a novel neuroprotective drug in experimental focal cerebral ischemia. J Neurol Sci 1999;162(2):114-119.

(143) Assaf Y, Holokovsky A, Berman E, Shapira Y, Shohami E, Cohen Y. Diffusion and perfusion magnetic resonance imaging following closed head injury in rats. J Neurotrauma 1999;16(12):1165-1176.

(144) Shohami E, Gati I, Beit-Yannai E, Trembovler V, Kohen R. Closed head injury in the rat induces whole body oxidative stress: Overall reducing antioxidant profile. J Neurotrauma 1999;16(5):365-376.

(145) Shohami E, Ginis I, Hallenbeck JM. Dual role of tumor necrosis factor alpha in brain injury. Cytokine Growth Factor Rev 1999;10(2):119-130.

(146) Chapman S, Grauer E, Chen Y, Shohami E, Weinstock M, Michaelson DM. The cognitive and neurochemical effects of the acetylcholinesterase inhibitor ENA713 on apolipoprotein E-deficient mice. Int J Geriatr Psychopharmacol 1998;1(3):171-175.

(147) Abu-Raya S, Bloch-Shilderman E, Shohami E, Trembovler V, Shai Y, Weidenfeld J, et al. Pardaxin, a new pharmacological tool to stimulate the arachidonic acid cascade in PC12 cells. J Pharmacol Exp Ther 1998;287(3):889-896.

(148) Beit-Yannai E, Trembovler V, Horowitz M, Lazarovici P, Kohen R, Shohami E. Neuroprotection against oxidative stress by serum from heat acclimated rats. Neurosci Lett 1998;254(2):89-92.

(149) Chen Y, Shohami E, Bass R, Weinstock M. Cerebro-protective effects of ENA713, a novel acetylcholinesterase inhibitor, in closed head injury in the rat. Brain Res 1998;784(1-2):18-24.

(150) Zhang R, Shohami E, Beit-Yannai E, Bass R, Trembovler V, Samuni A. Mechanism of brain protection by nitroxide radicals in experimental model of closed-head injury. Free Radic Biol Med 1998;24(2):332-340.

(151) Chen Y, Shohami E, Constantini S, Weinstock M. Rivastigmine, a Brain-Selective Acetylcholinesterase Inhibitor, Ameliorates Cognitive and Motor Deficits Induced by Closed-Head Injury in the Mouse. J Neurotrauma 1998;15(4):231-237.

(152) Chapman S, Fisher A, Weinstock M, Brandies R, Shohami E, Michaelson DM. The effects of the acetylcholinesterase inhibitor ENA713 and the M1 agonist AF150(S) on apolipoprotein E deficient mice. J Physiol Paris 1998;92(3-4):299-303.

(153) Zhang R, Shohami E, Beit-Yannai E, Bass R, Trembovler V, Samuni A. Erratum: Mechanism of brain protection by nitroxide radicals in experimental model of closed-head injury (Free Radical and Biology Medicine (1998) 24 (332-3410)). Free Radic Biol Med 1998;25(6):753.

(154) Gallily R, Yamin A, Waksmann Y, Ovadia H, Weidenfeld J, Bar-Joseph A, et al. Protection against septic shock and suppression of tumor necrosis factor α and nitric oxide production by dexanabinol (HU-211), a nonpsychotropic cannabinoid. J Pharmacol Exp Ther 1997;283(2):918-924.

(155) Ellren-Kashi O, Trembovler V, Abu-Raya S, Lazarovici P, Shohami E. Neuroprotective effects of gangliosides on pardaxin-induced toxicity in PC12 cells. J Nat Toxins 1997;6(3):285-292.

(156) Chen Y, Lomnitski L, Michaelson DM, Shohami E. Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury. Neuroscience 1997;80(4):1255-1262.

(157) Lomnitski L, Kohen R, Chen Y, Shohami E, Trembovler V, Vogel T, et al. Reduced levels of antioxidants in brains of apolipoprotein E-deficient mice following closed head injury. Pharmacol Biochem Behav 1997;56(4):669-673.

(158) Shohami E, Gallily R, Mechoulam R, Bass R, Ben-Hur T. Cytokine production in the brain following closed head injury: Dexanabinol (HU-211) is a novel TNF-α inhibitor and an effective neuroprotectant. J Neuroimmunol 1997;72(2):169-177.

(159) Beit-Yannai E, Kohen R, Horowitz M, Trembovler V, Shohami E. Changes of biological reducing activity in rat brain following closed head injury: A cyclic voltammetry study in normal and heat-acclimated rats. J Cereb Blood Flow Metab 1997;17(3):273-279.

(160) Shohami E, Beit-Yannai E, Horowitz M, Kohen R. Oxidative stress in closed-head injury: Brain antioxidant capacity as an indicator of functional outcome. J Cereb Blood Flow Metab 1997;17(10):1007-1019.

(161) Assaf Y, Beit-Yannai E, Shohami E, Berman E, Cohen Y. Diffusion- and T2-weighted MRI of closed-head injury in rats: A time course study and correlation with histology. Magn Reson Imaging 1997;15(1):77-85.

(162) Kozlovsky N, Shohami E, Bashan N. Increased PLA2 activity is not related to increased GLUT1 expression in L6 myotubes under hypoxic conditions. PROSTAGLANDINS LEUKOTRIENES ESSENT FATTY ACIDS 1997;56(1):17-22.

(163) Shohami E, Weidenfeld J, Ovadia H, Vogel Z, Hanuš L, Fride E, et al. Endogenous and synthetic cannabinoids: Recent advances. CNS Drug Rev 1996;2(4):429-451.

(164) Beit-Yannai E, Zhang R, Trembovler V, Samuni A, Shohami E. Cerebroprotective effect of stable nitroxide radicals in closed head injury in the rat. Brain Res 1996;717(1-2):22-28.

(165) Bass R, Engelhard D, Trembovler V, Shohami E. A novel nonpsychotropic cannabinoid, HU-211, in the treatment of experimental pneumococcal meningitis. J Infect Dis 1996;173(3):735-738.

(166) Glantz L, Nates JL, Trembovler V, Bass R, Shohami E. Irradiation Induced Blood Flow Changes in the Breast During Radiotherapy - A Pilot Study. J Basic Clin Physiol Pharmacol 1996;7(1):1-10.

(167) Chen Y, Constantini S, Trembovler V, Weinstock M, Shohami E. An experimental model of closed head injury in mice: Pathophysiology, histopathology, and cognitive deficits. J Neurotrauma 1996;13(10):557-568.

(168) Feldman Z, Gurevitch B, Artru AA, Oppenheim A, Shohami E, Reichenthal E, et al. Effect of magnesium given 1 hour after head trauma on brain edema and neurological outcome. J Neurosurg 1996;85(1):131-137.

(169) Shohami E, Bass R, Wallach D, Yamin A, Gallily R. Inhibition of tumor necrosis factor alpha (TNFα) activity in rat brain is associated with cerebroprotection after closed head injury. J Cereb Blood Flow Metab 1996;16(3):378-384.

(170) Pinson A, Tirosh R, Tremblover V, Shohami E. Oxygen deprivation and reoxygenation augment prostacyclin synthesis in cultured ventricular myocytes. PROSTAGLANDINS LEUKOTRIENES ESSENT FATTY ACIDS 1996;54(3):211-215.

(171) Nadler V, Biegon A, Beit-Yannai E, Adamchik J, Shohami E. 45Ca accumulation in rat brain after closed head injury; attenuation by the novel neuroprotective agent HU-211. Brain Res 1995;685(1-2):1-11.

(172) Shohami E, Novikov M, Bass R. Long-term effect of HU-211, a novel non-competitive NMDA antagonist, on motor and memory functions after closed head injury in the rat. Brain Res 1995;674(1):55-62.

(173) Shohami E, Bass R, Trembovler V, Weidenfeld J. The Effect of the Adrenocortical Axis upon Recovery from Closed Head Injury. J Neurotrauma 1995;12(6):1069-1077.

(174) Pinson A, Zilberman Y, Tirosh R, Trembovler V, Shohami E. High oligomycin concentrations augment 6-keto-PGF1α production in ventricular cardiomyocytes. Biochim Biophys Acta Lipids Lipid Metab 1994;1211(3):283-288.

(175) Shohami E, Novikov M, Bass R, Yamin A, Gallily R. Closed head injury triggers early production of TNFα and IL-6 by brain tissue. J Cereb Blood Flow Metab 1994;14(4):615-619.

(176) Shohami E, Novikov M, Horowitz M. Long term exposure to heat protects against brain damage induced by closed head injury in the rat. Restor Neurol Neurosci 1994;6(2):107-112.

(177) Shohami E, Novikov M, Horowitz M. Long term exposure to heat reduces edema formation after closed head injury in the rat. Acta Neurochir Suppl (Wien) 1994;60:443-445.

(178) Shalit M, Brenner T, Shohami E, Levi-Schaffer F. Interaction between mast cells and glial cells: an in vitro study. J Neuroimmunol 1993;43(1-2):195-199.

(179) Weidenfeld J, Amir I, Shohami E. Role of glucocorticoids in the regulation of brain prostaglandin biosynthesis under basal conditions and in response to endotoxin. Endocrinology 1993;132(3):941-945.

(180) Boneh A, Shohami E, Brenner T. Differential effects of phorbol myristate acetate and dexamethasone on protein kinase C activity and eicosanoids production in cultured rat astrocytes. J Neurosci Res 1993;34(6):629-634.

(181) Raya SA, Trembovler V, Shohami E, Lazarovici P. Cytolysins increase intracellular calcium and induce eicosanoids release by pheochromocytoma PC12 cell cultures. Nat Toxins 1993;1(5):263-270.

(182) Constantini S, Tamir J, Gomori MJ, Shohami E. Tumor prostaglandin levels correlate with edema around supratentorial meningiomas. Neurosurgery 1993;33(2):204-211.

(183) Shapira Y, Shohami E. Experimental studies on brain oedema after blunt head injury: Experimental approaches from animal experimentation to actual or possible clinical application. Eur J Anaesthesiol 1993;10(3):155-173.

(184) Shohami E, Novikov M, Mechoulam R. A Nonpsychotropic Cannabinoid, HU-211, Has Cerebroprotective Effects After Closed Head Injury in the Rat. J Neurotrauma 1993;10(2):109-119.

(185) Shapira Y, Setton D, Artru AA, Shohami E. Blood-brain barrier permeability, cerebral edema, and neurologic function after closed head injury in rats. Anesth Analg 1993;77(1):141-148.

(186) Raya SA, Trembovler V, Shohami E, Lazarovici P. A tissue culture ischemic device to study eicosanoid release by pheochromocytoma PC12 cultures. J Neurosci Methods 1993;50(2):197-203.

(187) Shohami E, Glantz L, Nates J, Feuerstein G. The mixed lipoxygenase/cyclooxygenase inhibitor sk&f 105809 reduces cerebral edema after closed head injury in rat. J Basic Clin Physiol Pharmacol 1992;3(2):99-108.

(188) Shapira Y, Artru AA, Yadid G, Shohami E. Methylprednisolone does not decrease eicosanoid concentrations or edema in brain tissue or improve neurologic outcome after head trauma in rats. Anesth Analg 1992;75(2):238-244.

(189) Brenner T, Boneh A, Shohami E, Abramsky O, Weidenfeld J. Glucocorticoid regulation of eicosanoid production by glial cells under basal and stimulated conditions. J Neuroimmunol 1992;40(2-3):273-279.

(190) Shohami E, Nates JL, Glantz L, Trembovler V, Shapira Y, Bachrach U. Changes in brain polyamine levels following head injury. Exp Neurol 1992;117(2):189-195.

(191) Shapira Y, Lam AM, Artru AA, Shohami E. Hypothermia but not nmda receptor antagonist mk-801 attenuates neuron damage: Are the results conclusive? J Neurosurg Anesthesiol 1992;4(3):221-222.

(192) Pinson A, Halabi A, Shohami E. Mechanical injury increases eicosanoid production in cultured cardiomyocytes. Prostaglandins Leukotrienes Essent Fatty Acids 1992;46(1):9-13.

(193) Weidenfeld J, Kahbha K, Reches A, Shohami E. Role of the Central Adrenergic System in the Regulation of Prostaglandin Biosynthesis in Rat Brain. J Neurochem 1992;58(2):694-699.

(194) Shapira Y, Artru A, Shohami E, Cotev S. Neurological improvement despite gradual increase in brain edema at 1-48 h after head trauma. J Neurosurg Anesthesiol 1991;3(3):210.

(195) Shohami E, Shapira Y, Rosenthal J, Reches A. Superoxide dismutase activity is not affected by closed head injury in rats. J Basic Clin Physiol Pharmacol 1991;2(1-2):103-110.

(196) Shohami E, Cotev S, Shapira Y. The role of eicosanoids in the development of delayed brain damage. J Basic Clin Physiol Pharmacol 1990;1(1-4):203-206.

(197) Siegal T, Siegal T, Shohami E, Lossos F. Experimental neoplastic spinal cord compression: Effect of ketamine and MK-801 on edema and prostaglandins. Neurosurgery 1990;26(6):963-966.

(198) Chajek-Shaul T, Barash V, Weidenfeld J, Friedman G, Ziv E, Shohami E, et al. Lethal hypoglycemia and hypothermia induced by administration of low doses of tumor necrosis factor to adrenalectomized rats. Metab Clin Exp 1990;39(3):242-250.

(199) Shapira Y, Cotev S, Yadid G, Shohami E, Niska A. Protective Effect of MK801 in Experimental Brain Injury. J Neurotrauma 1990;7(3):131-139.

(200) Weinberger A, Fadilah R, Lev A, Shohami E, Pinkhas J. Treatment of articular effusions with local deep microwave hyperthermia. Clin Rheumatol 1989;8(4):461-466.

(201) Weidenfeld J, Aburia S, Lysy J, Shohami E. Opposite effect of adrenalectomy on rat brain prostaglandin synthesis in basal conditions and in response to insulin or 2-deoxy-glucose. Prostaglandins Leukotrienes Essent Fatty Acids 1989;38(3):173-176.

(202) Shapira Y, Yadid G, Cotev S, Shohami E. OKY-046 inhibits thromboxane synthesis with no effect on brain edema and neurological status in head traumatized rats. Prostaglandins Leukotrienes Essent Fatty Acids 1989;36(1):49-55.

(203) Shohami E, Shapira Y, Yadid G, Reisfeld N, Yedgar S. Brain Phospholipase A2 Is Activated After Experimental Closed Head Injury in the Rat. J Neurochem 1989;53(5):1541-1546.

(204) SIEGAL T, SIEGAL T, SHAPIRA Y, SHOHAMI E. The Early Effect of Steroidal and Nonsteroidal Antiinflammatory Agents on Neoplastic Epidural Cord Compression. Ann New York Acad Sci 1989;559(1):488-490.

(205) SHOHAMI E, SHAPIRA Y, YADID G, COTEV S, FEUERSTEIN G. Increased 5‐HETE Production in the Brain following Head Injury. Ann New York Acad Sci 1989;559(1):485-487.

(206) Shapira Y, Yadid G, Cotev S, Shohami E. Accumulation of calcium in the brain following head trauma. Neurol Res 1989;11(3):169-172.

(207) Shapira Y, Shapira SC, Cotev S, Shohami E. The role of calcium in brain trauma and ischemia. Harefuah 1988;114(12):606-609.

(208) Weidenfeld J, Abu-Amer Y, Shohami E. Inhibition of prostaglandin synthesis in brain of rat by dexamethasone: Lack of effect of dexamethasone phosphate ester and various hormonal steroids. Neuropharmacology 1988;27(12):1295-1299.

(209) Shapira Y, Shohami E, Sidi A, Soffer D, Freeman S, Cotev S. Experimental closed head injury in rats: Mechanical, pathophysiologic, and neurologic properties. Crit Care Med 1988;16(3):258-265.

(210) Shapira Y, Davidson E, Weidenfeld Y, Cotev S, Shohami E. Dexamethasone and indomethacin do not affect brain edema following head injury in rats. J Cereb Blood Flow Metab 1988;8(3):395-402.

(211) Shohami E, Shapira Y, Cotev S. Experimental closed head injury in rats: Prostaglandin production in a noninjured zone. Neurosurgery 1988;22(5):859-863.

(212) Siegal T, Shohami E, Shapira Y, Siegal T. Indomethacin and dexamethasone treatment in experimental neoplastic spinal cord compression: Part 2. Effect on edema and prostaglandin synthesis. Neurosurgery 1988;22(2):334-339.

(213) Siegal T, Siegal T, Shohami E, Shapira Y. Comparison of soluble dexamethasone sodium phosphate with free dexamethasone and indomethacin in treatment of experimental neoplastic spinal cord compression. Spine 1988;13(10):1171-1176.

(214) Shohami E, Wisotsky B, Kempski O, Feuerstein G. Therapeutic Effect of Dexamethasone in T-2 Toxicosis. Pharm Res 1987;4(6):527-530.

(215) Jacobs TP, Shohami E, Baze W, Burgard E, Gunderson C, Hallenbeck J, et al. Thromboxane and 5-Hete Increase After Experimental Spinal Cord Injury in Rabbits. Cent Nerv Syst Trauma 1987;4(2):95-118.

(216) Forsberg EJ, Feuerstein G, Shohami E, Pollard HB. Adenosine triphosphate stimulates inositol phospholipid metabolism and prostacyclin formation in adrenal medullary endothelial cells by means of P2-purinergic receptors. Proc Natl Acad Sci U S A 1987;84(16):5630-5634.

(217) Segal T, Siegal T, Sandbank HU, Shohami E, Shapira J, Gomori JM, et al. Experimental neoplastic spinal cord compression: Evoked potentials, edema, prostaglandins, and light and electron microscopy. Spine 1987;12(5):440-448.

(218) Jacobs TP, Shohami E, Baze W, Burgard E, Gunderson C, Hallenbeck JM, et al. Deteriorating stroke model: Histopathology, edema, and eicosanoid changes following spinal cord ischemia in rabbits. Stroke 1987;18(4):741-750.

(219) Weidenfeld J, Lysy J, Shohami E. Effect of Dexamethasone on Prostaglandin Synthesis in Various Areas of the Rat Brain. J Neurochem 1987;48(5):1351-1354.

(220) Shohami E, Jacobs TP, Hallenbeck JM, Feuerstein G. Increased thromboxane A2 and 5-HETE production following spinal cord ischemia in the rabbit. Prostaglandins Leukotrienes Med 1987;28(2):169-181.

(221) Shohami E, Shapira Y, Sidi A, Cotev S. Head injury induces increased prostaglandin synthesis in rat brain. J Cereb Blood Flow Metab 1987;7(1):58-63.

(222) Kempski O, Shohami E, Von Lubitz D, Hallenbeck JM, Feuerstein G. Postischemic production of eicosanoids in gerbil brain. Stroke 1987;18(1):111-119.

(223) Koren R, Ravid A, Rotem C, Shohami E, Liberman UA, Novogrodsky A. 1,25-Dihydroxyvitamin D3 enhances prostaglandin E2 production by monocytes. A mechanism which partially accounts for the antiproliferative effect of 1,25(OH)2D3 on lymphocytes. FEBS Lett 1986;205(1):113-116.

(224) Shohami E, Gross J. Effects of Hypoxia and Anoxia on the Ex Vivo Release of Prostaglandins from Mouse Cortical Slices. J Neurochem 1986;47(6):1678-1681.

(225) Shohami E, Feuerstein G. T-2 toxemia and brain prostaglandins. Prostaglandins 1986;31(2):307-319.

(226) Shohami E, Evron S, Weinstock M, Soffer D, Carmon A. A new animal model for action myoclonus. Adv Neurol 1986;43:545-552.

(227) Shohami E, Globus M, Weidenfeld J. Regional distribution of prostanoids in rat brain: effect of insulin and 2-deoxyglucose. Exp Brain Res 1985;61(1):87-90.

(228) Arad I, Sidi A, Shohami E. Effect of Acute Hypoxia on Ascorbate Content of Plasma, Cerebral Cortex, and Adrenal Gland. J Neurochem 1985;45(3):766-769.

(229) Shohami E, Evron S. Intrathecal Morphine Induces Myoclonic Seizures in the Rat. Acta Pharmacol Toxicol 1985;56(1):50-54.

(230) Shohami E, Gross J. An Ex Vivo Method for Evaluating Prostaglandin Synthetase Activity in Cortical Slices of Mouse Brain. J Neurochem 1985;45(1):132-136.

(231) Segal M, Shohami E, Jacobowitz DM. Phenylethylamine, norepinephrine and mounting behavior in the male rat. Pharmacol Biochem Behav 1984;20(1):133-135.

(232) Shohami E, Sidi A. Accumulation of prostacyclin in rat brain during haemorrhagic hypotension - Possible role of PGI2 in autoregulation. J Cereb Blood Flow Metab 1984;4(1):107-109.

(233) Goitein KJ, Shohami E. Intracranial pressure during prolonged experimental convulsions in cats. J Neurol 1983;230(4):259-266.

(234) Shohami E, Segal M, Jacobowitz DM. Application of high-performance liquid chromatography with electrochemical detection to the determination of catecholamines in microdissected regions of the rat brain. J Neurosci Methods 1983;8(3):275-281.

(235) Weinstock M, Dalith M, Shohami E. Hypersensitivity of morphine-tolerant rabbits to the respiratory stimulant effect of a cholinergic agonist. J Pharmacol Exp Ther 1983;226(1):232-237.

(236) Shohami E, Rosenthal J, Lavy S. Thromboxane in rat brain following incomplete ischemia. Harefuah 1982;103(10):229-231+292.

(237) Gardiner M, Smith ML, Kagstrom E, Shohami E, Siesjö BK. Influence of blood glucose concentration on brain lactate accumulation during severe hypoxia and subsequent recovery of brain energy metabolism. J Cereb Blood Flow Metab 1982;2(4):429-438.

(238) Shohami E, Rosenthal J, Lavy S. The effect of incomplete cerebral ischemia on prostaglandin levels in rat brain. Stroke 1982;13(4):494-499.

(239) Shohami E, Kanner N, Koren R. S-substituted derivatives of 6-mercaptopurine ribosides interact both with the transport and metabolic phosphorylation of uridine by virus-transformed hamster fibroblasts. Biochim Biophys Acta Biomembr 1980;601(C):206-219.

(240) Koren R, Shohami E. The interaction of ionophore A23187 with the uridine uptake system of quiescent and serum-activated hamster fibroblasts. Exp Cell Res 1980;127(1):55-61.

(241) KOREN R, SHOHAMI E, YEROUSHALMI S. A Kinetic Analysis of the Uptake of Cytosine‐β‐d‐Arabinoside by Rat‐B77 Cells: Differentiation between Transport and Phosphorylation. Eur J Biochem 1979;95(2):333-339.

(242) Shohami E, Koren R. S-(N-Dansylaminoethyl)-6-mercaptoguanosine as a fluorescent probe for the uridine transport system in human erythrocytes. Biochem J 1979;178(2):271-277.

(243) Bibi O, Schwartz J, Eilam Y, Shohami E, Cabantchik ZI. Nucleoside transport in mammalian cell membranes - IV. Organomercurials and organomercurial-mercaptonucleoside complexes as probes for nucleoside transport systems in hamster cells. J Membrain Biol 1978;39(2-3):159-183.

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