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School of Pharmacy : Tirosh Boaz


 Last updated December 2021 - School of Pharmacy

List of Publications

(1) Seidel E, Dassa L, Kahlon S, Tirosh B, Halenius A, Seidel Malkinson T, et al. A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain. Nat Commun 2021;12(1).

(2) Anand A, Sharma A, Ravins M, Biswas D, Ambalavanan P, Lim KXZ, et al. Unfolded protein response inhibitors cure group A streptococcal necrotizing fasciitis by modulating host asparagine. Sci Transl Med 2021;13(605).

(3) Sarsenbayeva A, Dipta P, Lundqvist M, Almby KE, Tirosh B, Di Nunzio G, et al. Human macrophages stimulate expression of inflammatory mediators in adipocytes; effects of second-generation antipsychotics and glucocorticoids on cellular cross-talk. Psychoneuroendocrinology 2021;125.

(4) Mahameed M, Boukeileh S, Obiedat A, Darawshi O, Dipta P, Rimon A, et al. Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy. Nat Commun 2020;11(1).

(5) Tabachnick-Cherny S, Pinto S, Berko D, Curato C, Wolf Y, Porat Z, et al. Polyglutamine-related aggregates can serve as a potent antigen source for cross-presentation by dendritic cells. J Immunol 2020;205(10):2583-2594.

(6) Drori A, Gammal A, Azar S, Hinden L, Hadar R, Wesley D, et al. Cb1r regulates soluble leptin receptor levels via chop, contributing to hepatic leptin resistance. eLife 2020;9:1-26.

(7) Forno F, Maatuf Y, Boukeileh S, Dipta P, Mahameed M, Darawshi O, et al. Erratum: Aripiprazole Cytotoxicity Coincides with Activation of the Unfolded Protein Response in Human Hepatic Cells (Journal of Pharmacology and Experimental Therapeutics (2020) 374 (452-461) DOI: 10.1124/jpet.119.264481). J Pharmacol Exp Ther 2020;374(3):529.

(8) Forno F, Maatuf Y, Boukeileh S, Dipta P, Mahameed M, Darawshi O, et al. Aripiprazole cytotoxicity coincides with activation of the unfolded protein response in human hepatic cells. J Pharmacol Exp Ther 2020;374(3):452-461.

(9) Kogot-Levin A, Hinden L, Riahi Y, Israeli T, Tirosh B, Cerasi E, et al. Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors. Cell Rep 2020;32(4).

(10) Hinte F, Van Anken E, Tirosh B, Brune W. Repression of viral gene expression and replication by the unfolded protein response effector XBP1U. eLife 2020;9.

(11) Obiedat A, Charpak-Amikam Y, Tai-Schmiedel J, Seidel E, Mahameed M, Avril T, et al. The integrated stress response promotes B7H6 expression. J Mol Med 2020;98(1):135-148.

(12) Mahameed M, Wilhelm T, Darawshi O, Obiedat A, Tommy W-, Chintha C, et al. The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors. Cell Death Dis 2019;10(4).

(13) Obiedat A, Seidel E, Mahameed M, Bernani O, Tsukerman P, Voutetakis K, et al. Transcription of the NKG2D ligand MICA is suppressed by the IRE1/XBP1 pathway of the unfolded protein response through the regulation of E2F1. FASEB J 2019;33(3):3481-3495.

(14) Mahameed M, Obiedat A, Beck G, Johnson JC, Tirosh B. Low concentrations of cadmium chloride promotes protein translation and improve cell line productivity. Biotechnol Bioeng 2019;116(3):569-580.

(15) Mahameed M, Sulieman A, Alkam D, Tirosh B. Towards enhancing therapeutic glycoprotein bioproduction: Interventions in the PI3K/AKT/mTOR pathway. Cell Struct Funct 2019;44(2):75-83.

(16) Weiss-Sadan T, Itzhak G, Kaschani F, Yu Z, Mahameed M, Anaki A, et al. Cathepsin L regulates metabolic networks controlling rapid cell growth and proliferation. Mol Cell Proteomics 2019;18(7):1330-1344.

(17) Meena NK, Pattanayak SP, Ben-Nun Y, Benhamron S, Kumar S, Merquiol E, et al. mTORC1 activation in B cells confers impairment of marginal zone microarchitecture by exaggerating cathepsin activity. Immunology 2018;155(4):505-518.

(18) Israeli T, Riahi Y, Saada A, Yefet D, Cerasi E, Tirosh B, et al. Opposing effects of intracellular versus extracellular adenine nucleotides on autophagy: Implications for β-cell function. J Cell Sci 2018;131(15).

(19) Wilhelm T, Bick F, Peters K, Mohta V, Tirosh B, Patterson JB, et al. Infliction of proteotoxic stresses by impairment of the unfolded protein response or proteasomal inhibition as a therapeutic strategy for mast cell leukemia. Oncotarget 2018;9(3):2984-3000.

(20) Mahameed M, Tirosh B. Engineering CHO cells with an oncogenic KIT improves cells growth, resilience to stress, and productivity. Biotechnol Bioeng 2017;114(11):2560-2570.

(21) Tiwari S, Tirosh B, Rubinstein A. Increasing the affinity of cationized polyacrylamide-paclitaxel nanoparticles towards colon cancer cells by a surface recognition peptide. Int J Pharm 2017;531(1):281-291.

(22) Demishtein A, Fraiberg M, Berko D, Tirosh B, Elazar Z, Navon A. SQSTM1/p62-mediated autophagy compensates for loss of proteasome polyubiquitin recruiting capacity. Autophagy 2017;13(10):1697-1708.

(23) Erez N, Hubel E, Avraham R, Cohen R, Fishman S, Bantel H, et al. Hepatic amiodarone lipotoxicity is ameliorated by genetic and pharmacological inhibition of endoplasmatic reticulum stress. Toxicol Sci 2017;159(2):402-412.

(24) McVey D, Aronov M, Rizzi G, Cowan A, Scott C, Megill J, et al. CHO cells knocked out for TSC2 display an improved productivity of antibodies under fed batch conditions. Biotechnol Bioeng 2016;113(9):1942-1952.

(25) Aronov M, Tirosh B. Metabolic Control of Plasma Cell Differentiation- What We Know and What We Don't Know. J Clin Immunol 2016;36:12-17.

(26) Omar I, Lapenna A, Cohen-Daniel L, Tirosh B, Berger M. Schlafen2 mutation unravels a role for chronic ER stress in the loss of T cell quiescence. Oncotarget 2016;7(26):39396-39407.

(27) Seidel E, Le VTK, Bar-On Y, Tsukerman P, Enk J, Yamin R, et al. Dynamic Co-evolution of Host and Pathogen: HCMV Downregulates the Prevalent Allele MICA*008 to Escape Elimination by NK Cells. Cell Rep 2015;10(6):968-982.

(28) Benhamron S, Pattanayak SP, Berger M, Tirosh B. mTOR activation promotes plasma cell differentiation and bypasses XBP-1 for immunoglobulin secretion. Mol Cell Biol 2015;35(1):153-166.

(29) Drori A, Messerle M, Brune W, Tirosh B. Lack of XBP-1 impedes murine cytomegalovirus gene expression. PLoS ONE 2014;9(10).

(30) Baruch M, Hertzog BB, Ravins M, Anand A, Cheng CY, Biswas D, et al. Induction of endoplasmic reticulum stress and unfolded protein response constitutes a pathogenic strategy of group A streptococcus. Front Cell Infect Microbiol 2014;4(AUG).

(31) Benhamron S, Hadar R, Iwawaky T, So J-, Lee A-, Tirosh B. Regulated IRE1-dependent decay participates in curtailing immunoglobulin secretion from plasma cells. Eur J Immunol 2014;44(3):867-876.

(32) Scaiewicz V, Nahmias A, Chung RT, Mueller T, Tirosh B, Shibolet O. CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model. PLoS ONE 2013;8(12).

(33) Park W-, Park J-, Erez-Roman R, Kogot-Levin A, Bame JR, Tirosh B, et al. Protection of a ceramide synthase 2 null mouse from drug-induced liver injury role of gap junction dysfunction and connexin 32 mislocalization. J Biol Chem 2013;288(43):30904-30916.

(34) Uzi D, Barda L, Scaiewicz V, Mills M, Mueller T, Gonzalez-Rodriguez A, et al. CHOP is a critical regulator of acetaminophen-induced hepatotoxicity. J Hepatol 2013;59(3):495-503.

(35) Stahl S, Burkhart JM, Hinte F, Tirosh B, Mohr H, Zahedi RP, et al. Cytomegalovirus Downregulates IRE1 to Repress the Unfolded Protein Response. PLoS Pathog 2013;9(8).

(36) Alfassy OS, Cohen I, Reiss Y, Tirosh B, Ravid T. Placing a disrupted degradation motif at the C terminus of proteasome substrates attenuates degradation without impairing ubiquitylation. J Biol Chem 2013;288(18):12645-12653.

(37) Bachar-Wikstrom E, Wikstrom JD, Ariav Y, Tirosh B, Kaiser N, Cerasi E, et al. Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes. Diabetes 2013;62(4):1227-1237.

(38) Berko D, Tabachnick-Cherny S, Shental-Bechor D, Cascio P, Mioletti S, Levy Y, et al. The Direction of Protein Entry into the Proteasome Determines the Variety of Products and Depends on the Force Needed to Unfold Its Two Termini. Mol Cell 2012;48(4):601-611.

(39) Shteingart S, Hadar R, Cohen I, Ravid T, Tirosh B. Endoplasmic reticulum stress induces a caspase-dependent N-terminal cleavage of RBX1 protein in B cells. J Biol Chem 2012;287(37):31223-31232.

(40) Merquiol E, Uzi D, Mueller T, Goldenberg D, Nahmias Y, Xavier RJ, et al. HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response. PLoS ONE 2011;6(9).

(41) Harel E, Rubinstein A, Nissan A, Khazanov E, Milbauer M, Barenholz Y, et al. Enhanced transferrin receptor expression by proinflammatory cytokines in enterocytes as a means for local delivery of drugs to inflamed gut mucosa. PLoS ONE 2011;6(9).

(42) Shimshon L, Michaeli A, Hadar R, Nutt SL, David Y, Navon A, et al. SUMOylation of blimp-1 promotes its proteasomal degradation. FEBS Lett 2011;585(15):2405-2409.

(43) Benhamron S, Tirosh B. Direct activation of mTOR in B lymphocytes confers impairment in B-cell maturation andloss of marginal zone B cells. Eur J Immunol 2011;41(8):2390-2396.

(44) Hu F, Yu X, Wang H, Zuo D, Guo C, Yi H, et al. ER stress and its regulator X-box-binding protein-1 enhance polyIC-induced innate immune response in dendritic cells. Eur J Immunol 2011;41(4):1086-1097.

(45) Goldfinger M, Shmuel M, Benhamron S, Tirosh B. Protein synthesis in plasma cells is regulated by crosstalk between endoplasmic reticulum stress and mTOR signaling. Eur J Immunol 2011;41(2):491-502.

(46) Drori A, Tirosh B. Regulation of immunoglobulin synthesis, modification, and trafficking by the unfolded protein response: A quantitative approach. Methods Enzymol 2011;491:309-325.

(47) Harel E, Rubinstein A, Chen W, Breuer E, Tirosh B. Aminoalkylcarbamoylphosphonates reduce TNFα release from activated immune cells. Bioorg Med Chem Lett 2010;20(22):6518-6523.

(48) Drori A, Misaghi S, Haimovich J, Messerle M, Tirosh B. Prolonged endoplasmic reticulum stress promotes mislocalization of immunoglobulins to the cytoplasm. Mol Immunol 2010;47(9):1719-1727.

(49) Navon A, Gatushkin A, Zelcbuch L, Shteingart S, Farago M, Hadar R, et al. Direct proteasome binding and subsequent degradation of unspliced XBP-1 prevent its intracellular aggregation. FEBS Lett 2010;584(1):67-73.

(50) Abu-Gosh SE, Kolvazon N, Tirosh B, Ringel I, Yavin E. Multiple triphenylphosphonium cations shuttle a hydrophilic peptide into mitochondria. Mol Pharm 2009;6(4):1138-1144.

(51) Tirosh B, Khatib N, Barenholz Y, Nissan A, Rubinstein A. Transferrin as a luminal target for negatively charged liposomes in the inflamed colonic mucosa. Mol Pharm 2009;6(4):1083-1091.

(52) Goldfinger M, Laviad EL, Hadar R, Shmuel M, Dagan A, Park H, et al. De novo ceramide synthesis is required for n-linked glycosylation in plasma cells. J Immunol 2009;182(11):7038-7047.

(53) Pardo M, Budick-Harmelin N, Tirosh B, Tirosh O. Antioxidant defense in hepatic ischemia-reperfusion injury is regulated by damage-associated molecular pattern signal molecules. Free Radic Biol Med 2008;45(8):1073-1083.

(54) Kario E, Tirosh B, Ploegh HL, Navon A. N-linked glycosylation does not impair proteasomal degradation but affects class I major histocompatibility complex presentation. J Biol Chem 2008;283(1):244-254.

(55) Tirosh B, Daniel-Carmi V, Carmon L, Paz A, Lugassy G, Vadai E, et al. '1-8 Interferon inducible gene family': Putative colon carcinoma-associated antigens. Br J Cancer 2007;97(12):1655-1663.

(56) Gruda R, Achdout H, Stern-Ginossar N, Gazit R, Betser-Cohen G, Manaster I, et al. Intracellular cysteine residues in the tail of MHC class I proteins are crucial for extracellular recognition by leukocyte Ig-like receptor. J Immunol 2007;179(6):3655-3661.

(57) Kumazaki K, Tirosh B, Maehr R, Boes M, Honjo T, Ploegh HL. AID-/-μs-/- mice are agammaglobulinemic and fail to maintain B220-CD138+ plasma cells. J Immunol 2007;178(4):2192-2203.

(58) Tirosh B, Iwakoshi NN, Glimcher LH, Ploegh HL. Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response. J Biol Chem 2006;281(9):5852-5860.

(59) Tirosh B, Iwakoshi NN, Glimcher LH, Ploegh HL. XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells. J Exp Med 2005;202(4):505-516.

(60) Machlenkin A, Paz A, Haim EB, Goldberger O, Finkel E, Tirosh B, et al. Human CTL epitopes prostatic acid phosphatase-3 and six-transmembrane epithelial antigen of prostate-3 as candidates for prostate cancer immunotherapy. Cancer Res 2005;65(14):6435-6442.

(61) Machlenkin A, Goldberger O, Tirosh B, Paz A, Volovitz I, Bar-Haim E, et al. Combined dendritic cell cryotherapy of tumor induces systemic antimetastatic immunity. Clin Cancer Res 2005;11(13):4955-4961.

(62) Tirosh B, Iwakoshi NN, Lilley BN, Lee A-, Glimcher LH, Ploegh HL. Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex products. J Virol 2005;79(5):2768-2779.

(63) Bar-Haim E, Paz A, Machlenkin A, Hazzan D, Tirosh B, Carmon L, et al. MAGE-A8 overexpression in transitional cell carcinoma of the bladder: Identification of two tumour-associated antigen peptides. Br J Cancer 2004;91(2):398-407.

(64) Tirosh B, Furman MH, Tortorella D, Ploegh HL. Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation. J Biol Chem 2003;278(9):6664-6672.

(65) Carmon L, Bobilev-Priel I, Brenner B, Bobilev D, Paz A, Bar-Haim E, et al. Characterization of novel breast carcinoma-associated BA46-derived peptides in HLA-A2.1/Db-β2m transgenic mice. J Clin Invest 2002;110(4):453-462.

(66) Tirosh B, Fridkin M, Tzehoval E, Vadai E, Lemonnier FA, Eisenbach L. Antigenicity and immunogenicity of an intracellular delivery system of major histocompatibility complex class I epitopes that bypasses proteasome processing. J Immunother 2000;23(6):622-630.

(67) Vaisman N, Nissim A, Klapper LN, Tirosh B, Yarden Y, Sela M. Specific inhibition of the reaction between a tumor-inhibitory antibody and the ErbB-2 receptor by a mimotope derived from a phage display library. Immunol Lett 2000;75(1):61-67.

(68) Carmon L, Tzehoval E, Tirosh B, El-Shami KM, Bar-Haim E, Vadai E, et al. Anti-tumor vaccination in heterozygous congenic F1 mice: Presentation of tumor-associated antigen by the two parental class I alleles. J Immunother 2000;23(3):344-352.

(69) Carmon L, El-Shami KM, Paz A, Pascolo S, Tzehoval E, Tirosh B, et al. Novel breast-tumor-associated MUC1-derived peptides: Characterization in D(b-)/- x β2 microglobulin (β2m) null mice transgenic for a chimeric HLA- A2.1/D(b)-β2 microglobulin single chain. Int J Cancer 2000;85(3):391-397.

(70) El-Shami KM, Tirosh B, Popovic D, Carmon L, Tzehoval E, Vadai E, et al. Induction of antitumor immunity by proteasome-inhibited syngeneic fibroblasts pulsed with a modified TAA peptide. Int J Cancer 2000;85(2):236-242.

(71) Tzehoval E, Vadai E, Eisenbach L, Tirosh B, Fridkin M, Lemonnier F. Antigenicity and immunogenicity of an intracellular delivery system of major histocompatibility complex class i epitopes that bypasses proteasome processing. J Immunother 2000;23(6):260.

(72) El-Shami K, Tirosh B, Bar-Haîm E, Carmon L, Vadai E, Fridkin M, et al. MHC class I-restricted epitope spreading in the context of tumor rejection following vaccination with a single immunodominant CTL epitope. Eur J Immunol 1999;29(10):3295-3301.

(73) Tirosh B, El-Shami K, Vaisman N, Carmon L, Bar-Haim E, Vadai E, et al. Immunogenicity of H-2Kb-low affinity, high affinity, and covalently-bound peptides in anti-tumor vaccination. Immunol Lett 1999;70(1):21-28.

(74) Tirosh B, Rubinstein A. Migration of adhesive and nonadhesive particles in the rat intestine under altered mucus secretion conditions. J Pharm Sci 1998;87(4):453-456.

(75) Rubinstein A, Tirosh B, Baluom M, Nassar T, David A, Radai R, et al. The rationale for peptide drug delivery to the colon and the potential of polymeric carriers as effective tools. J Control Release 1997;46(1-2):59-73.

(76) Tirosh B, Baluom M, Nassar T, Friedman M, Rubinstein A. The effect of Eudragit RL-100 on the mechanical and mucoadhesion properties of polycarbophil dosage forms. J Control Release 1997;45(1):57-64.

(77) Tirosh B, Nasser T, Friedman M, Rubinstein A. Eudragit RL-100 as a physical stabilizer of polycarbophil hydrogels. PROC CONTROL RELEASE SOC 1995(22):358-359.

(78) Rubinstein A, Tirosh B. Mucus Gel Thickness and Turnover in the Gastrointestinal Tract of the Rat: Response to Cholinergic Stimulus and Implication for Mucoadhesion. Pharm Res 1994;11(6):794-799.

(79) Tirosh B, Rubinstein A. The varied mucus secretory response of the rat GI tract to cholinergic stimulus. PROC CONTROL RELEASE SOC 1993(20):186-187.