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School of Pharmacy : Touitou Elka


 Last updated December 2021 - School of Pharmacy

List of Publications

(1) Touitou E, Natsheh H. Topical administration of drugs incorporated in carriers containing phospholipid soft vesicles for the treatment of skin medical conditions. Pharmaceutics 2021;13(12).

(2) Touitou E, Natsheh H, Boukeileh S, Awad R. Short onset and enhanced analgesia following nasal administration of non-controlled drugs in nanovesicular systems. Pharmaceutics 2021;13(7).

(3) Zoabi A, Touitou E, Margulis K. Recent advances in nanomaterials for dermal and transdermal applications. Colloids Interfaces 2021;5(1).

(4) Natsheh H, Touitou E. Phospholipid vesicles for dermal/transdermal and nasal administration of active molecules: The effect of surfactants and alcohols on the fluidity of their lipid bilayers and penetration enhancement properties. Molecules 2020;25(13).

(5) Touitou E, Duchi S, Natsheh H. A new nanovesicular system for nasal drug administration. Int J Pharm 2020;580.

(6) Natsheh H, Vettorato E, Touitou E. Ethosomes for dermal administration of natural active molecules. Curr Pharm Des 2019;25(21):2338-2348.

(7) Touitou E, Natsheh H, Duchi S. Buspirone nanovesicular nasal system for non-hormonal hot flushes treatment. Pharmaceutics 2018;10(3).

(8) Natsheh H, Touitou E. Phospholipid magnesome—A nasal vesicular carrier for delivery of drugs to brain. Drug Deliv Transl Res 2018;8(3):806-819.

(9) Allon I, Touitou E. Scrolls: novel microparticulate systems for enhanced delivery to/across the skin. Drug Deliv Transl Res 2016;6(1):24-37.

(10) Ainbinder D, Godin B, Touitou E. Ethosomes: Enhanced delivery of drugs to and across the skin. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Nanocarriers; 2016. p. 61-75.

(11) Cohen G, Natsheh H, Sunny Y, Bawiec CR, Touitou E, Lerman MA, et al. Enhanced Therapeutic Anti-Inflammatory Effect of Betamethasone on Topical Administration with Low-Frequency, Low-Intensity (20 kHz, 100 mW/cm2) Ultrasound Exposure on Carrageenan-Induced Arthritis in a Mouse Model. Ultrasound Med Biol 2015;41(9):2449-2457.

(12) Zailer J, Touitou E. Pouch drug delivery systems for dermal and transdermal administration. Drug Deliv Transl Res 2014;4(5-6):416-428.

(13) Peppas NA, Duncan R, Wnek GE, Hoffman AS, Gao GH, Kim SW, et al. Highly cited research articles in Journal of Controlled Release: Commentaries and perspectives by authors. J Control Release 2014;190:29-74.

(14) Touitou E, Ainbinde D. 7. Ethosomes - An innovative carrier for enhanced delivery into and across the skin: Original Research Article: Ethosomes - Novel vesicular carriers for enhanced delivery: Characterization skin penetration properties, 2000 References. J Control Release 2014;190:44-46.

(15) Duchi S, Ovadia H, Touitou E. Nasal administration of drugs as a new non-invasive strategy for efficient treatment of multiple sclerosis. J Neuroimmunol 2013;258(1-2):32-40.

(16) Touitou E, Illum L. Nasal drug delivery. Drug Deliv Transl Res 2013;3(1):1-3.

(17) Duchi S, Touitou E, Pradella L, Marchini F, Ainbinder D. Nasal Tramadol delivery system: A new approach for improved pain therapy. Eur J Pain Suppl 2011;5(2):449-452.

(18) Ainbinder D, Touitou E. A new approach for skin tumor treatment: From delivery system characterization to in vivo evaluation. Drug Deliv Transl Res 2011;1(1):53-65.

(19) Ainbinder D, Touitou E. Skin photodamage prevention: State of the art and new prospects. Textbook of Aging Skin; 2010. p. 429-440.

(20) Perumal O, Michniak-Kohn B, Touitou E, Roberts MS. A special issue on skin nanotechnology. J Biomed Nanotechnol 2010;6(5):405-407.

(21) Shumilov M, Bercovich R, Duchi S, Ainbinder D, Touitou E. Ibuprofen transdermal ethosomal gel: Characterization and efficiency in animal models. J Biomed Nanotechnol 2010;6(5):569-576.

(22) Ainbinder D, Paolino D, Fresta M, Touitou E. Drug delivery applications with ethosomes. J Biomed Nanotechnol 2010;6(5):558-568.

(23) Shumilov M, Touitou E. Buspirone transdermal administration for menopausal syndromes, in vitro and in animal model studies. Int J Pharm 2010;387(1-2):26-33.

(24) Ainbinder D, Protokin R, Chaouat M, Touitou E. Effect of honokiol and 5-FU on non-melanoma skin cancer cells. J Drug Deliv Sci Technol 2009;19(4):283-287.

(25) Shumilov M, Touitou E, Godin B, Ainbinder D, Yosha I, Tsahor-Ohayon H. Evaluation of a polysiloxane-collagen biphasic membrane: A model for in vitro skin permeation studies. J Drug Deliv Sci Technol 2009;19(4):289-294.

(26) Touitou E, Godin B. Skin nonpenetrating sunscreens for cosmetic and pharmaceutical formulations. Clin Dermatol 2008;26(4):375-379.

(27) Touitou E, Godin B, Shumilov M, Bishouty N, Ainbinder D, Shouval R, et al. Efficacy and tolerability of clindamycin phosphate and salicylic acid gel in the treatment of mild to moderate acne vulgaris. J Eur Acad Dermatol Venereol 2008;22(5):629-631.

(28) Godin B, Touitou E. Transdermal skin delivery: Predictions for humans from in vivo, ex vivo and animal models. Adv Drug Deliv Rev 2007;59(11):1152-1161.

(29) Touitou E, Godin B. Dermal drug delivery with ethosomes: Therapeutic potential. Therapy 2007;4(4):465-472.

(30) Klingemann H, Rainov NG, Smythe JA, Touitou E. Editorial Board Focus – May 2007. Expert Opin Biol Ther 2007;7(5):573-575.

(31) Touitou E, Godin B. Ethosomes for skin delivery. J Drug Deliv Sci Technol 2007;17(5):303-308.

(32) Touitou E, Godin B, Klein H, Ron A. In vitro estimation of effective NSAIDs plasma concentrations in humans by measuring morphometric changes in Tetrahymena. J Drug Deliv Sci Technol 2007;17(3):163-167.

(33) Touitou E, Waknine JH, Godin B, Golenser J. Treatment of malaria in a mouse model by intranasal drug administration. Int J Parasitol 2006;36(14):1493-1498.

(34) Touitou E, Godin B. New approaches for UV-induced photodamage protection. J Appl Cosmetol 2006;24(4):139-147.

(35) Touitou E, Barry BW. Preface. Enhancement in Drug Delivery 2006:iv-v.

(36) Touitou E, Barry BW. Enhancement in drug delivery. Enhancement in Drug Delivery; 2006. p. 1-631.

(37) Touitou E, Godin B. Vesicular Carriers for Enhanced delivery through the skin. Enhancement in Drug Delivery; 2006. p. 255-278.

(38) Godin B, Touitou E. Enhancers for enteral delivery of macromolecules with emphasis on surfactants. Enhancement in Drug Delivery; 2006. p. 36-56.

(39) Ainbinder D, Touitou E. Testosterone ethosomes for enhanced transdermal delivery. Drug Deliv J Deliv Targeting Ther Agents 2005;12(5):297-303.

(40) Godin B, Touitou E. Erythromycin ethosomal systems: Physicochemical characterization and enhanced antibacterial activity. Curr Drug Deliv 2005;2(3):269-275.

(41) Godin B, Touitou E, Rubinstein E, Athamna A, Athamna M. A new approach for treatment of deep skin infections by an ethosomal antibiotic preparation: An in vivo study. J Antimicrob Chemother 2005;55(6):989-994.

(42) Touitou E, Godin B. Enhanced skin permeation using ethosomes. Percutaneous Penetration Enhancers, Second Edition; 2005. p. 95-108.

(43) Godin B, Touitou E. Mechanism of bacitracin permeation enhancement through the skin and cellular membranes from an ethosomal carrier. J Control Release 2004;94(2-3):365-379.

(44) Lodzki M, Godin B, Rakou L, Mechoulam R, Gallily R, Touitou E. Cannabidiol - Transdermal delivery and anti-inflammatory effect in a murine model. J Control Release 2003;93(3):377-387.

(45) Godin B, Touitou E. Ethosomes: New prospects in transdermal delivery. Crit Rev Ther Drug Carrier Syst 2003;20(1):63-102.

(46) Touitou E. Drug delivery across the skin. Expert Opin Biol Ther 2002;2(7):723-733.

(47) Touitou E, Godin B, Karl Y, Bujanover S, Becker Y. Oleic acid, a skin penetration enhancer, affects Langerhans cells and corneocytes. J Control Release 2002;80(1-3):1-7.

(48) Touitou E, Godin B, Dayan N, Weiss C, Piliponsky A, Levi-Schaffer F. Intracellular delivery mediated by an ethosomal carrier. Biomaterials 2001;22(22):3053-3059.

(49) Evrard D, Touitou E, Kolusheva S, Fishov Y, Jelinek R. A new colorimetric assay for studying and rapid screening of membrane penetration enhancers. Pharm Res 2001;18(7):943-949.

(50) Meidan VM, Touitou E. Treatments for androgenetic alopecia and alopecia areata: Current options and future prospects. Drugs 2001;61(1):53-69.

(51) Dayan N, Touitou E. Carriers for skin delivery of trihexyphenidyl HCl: Ethosomes vs. liposomes. Biomaterials 2000;21(18):1879-1885.

(52) Levi-Schaffer F, Slovik D, Armetti L, Pickholtz D, Touitou E. Activation and inhibition of mast cells degranulation affect their morphometric parameters. Life Sci 2000;66(21):PL283-PL290.

(53) Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M. Ethosomes - Novel vesicular carriers for enhanced delivery: Characterization and skin penetration properties. J Control Release 2000;65(3):403-418.

(54) Touitou E, Godin B, Weiss C. Enhanced delivery of drugs into and across the skin by ethosomal carriers. Drug Dev Res 2000;50(3-4):406-415.

(55) Horwitz E, Pisanty S, Czerninski R, Heiser M, Eliav E, Touitou E. A clinical evaluation of a novel liposomal carrier for acyclovir in the topical treatment of recurrent herpes labialis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;87(6):700-705.

(56) Dayan N, Touitou E. Carriers for skin delivery of trihexyphenidyl HCl: Liposomes vs. ethosomes. Proc Control Release Soc 1999(26):443-444.

(57) Touitou E, Meidan VM, Horwitz E. Methods for quantitative determination of drug localized in the skin. J Control Release 1998;56(1-3):7-21.

(58) Meidan V, Alhaique F, Touitou E. Vesicular carriers for topical delivery. Acta Technol Legis Medicam 1998;9(1):1-6.

(59) Kaplun-Frischoff Y, Touitou E. Testosterone skin permeation enhancement by menthol through formation of eutectic with drug and interaction with skin lipids. J Pharm Sci 1997;86(12):1394-1399.

(60) Touitou E, Alkabes M, Memoli A, Alhaique F. Glutathione stabilizes ascorbic acid in aqueous solution. Int J Pharm 1996;133(1-2):85-88.

(61) Levi-Schaffer F, Dayan N, Touitou E. Diethylene glycol monoethyl ether (Transcutol®) displays antiproliferative properties alone and in combination with xanthines. Skin Pharmacol Physiol 1996;9(1):53-59.

(62) Touitou E, Chow DD, Lawter JR. Chiral β-blockers for transdermal delivery. Int J Pharm 1994;104(1):19-28.

(63) Touitou E, Deutsch J, Matar S. Iodine-polyurethane matrices: antimicrobial activity vs method of preparation. Int J Pharm 1994;103(2):199-202.

(64) Touitou E, Levi-Schaffer F, Dayan N, Alhaique F, Riccieri F. Modulation of caffeine skin delivery by carrier design: liposomes versus permeation enhancers. Int J Pharm 1994;103(2):131-136.

(65) Touitou E, Alkabes M, Fabin B, Katz D, Horwitz E, Touitou D. Quantitative skin autoradiography: An efficient tool in measuring drug localized in skin layers, hair follicles and glands. PROC CONTROL RELEASE SOC 1994(21):431-432.

(66) Touitou E, Junginger HE, Weiner ND, Nagai T, Mezei M. Liposomes as carriers for topical and transdermal delivery. J Pharm Sci 1994;83(9):1189-1203.

(67) Alhaique F, Carafa M, Riccieri FM, Santucci E, Touitou E. Studies on the release behaviour of a polysaccharide matrix. Pharmazie 1993;48(6):432-436.

(68) Touitou E, Gilhar D, Alhaique F, Memoli A, Riccieri FM, Santucci E. Ascorbic acid in aqueous solution: Bathochromic shift in dilution and degradation. Int J Pharm 1992;78(1-3):85-87.

(69) Touitou E. Enhancement of intestinal peptide absorption. J Control Release 1992;21(1-3):139-144.

(70) Touitou E, Shaco‐Ezra N, Dayan N, Jushynski M, Rafaeloff R, Azoury R. Dyphylline liposomes for delivery to the skin. J Pharm Sci 1992;81(2):131-134.

(71) Fabin B, Touitou E. Localization of lipophilic molecules penetrating rat skin in vivo by quantitative autoradiography. Int J Pharm 1991;74(1):59-65.

(72) Touitou E, Levi-Schaffer F, Shaco-Ezra N, Ben-Yossef R, Fabin B. Enhanced permeation of theophylline through the skin and its effect on fibroblast proliferation. Int J Pharm 1991;70(1-2):159-166.

(73) Levi-Schaffer F, Touitou E. Xanthines inhibit 3T3 fibroblast proliferation. Skin Pharmacol 1991;4(4):286-290.

(74) Alhaique F, Beltrami E, Riccieri FM, Santucci E, Touitou E. Scleroglucan sustained release oral preparations. Part II. Effects of additives. Drug Des Deliv 1990;5(3):249-257.

(75) Touitou E. Buoyant sustained release granules based on chitosan: Comments on the article by Inouye et al. Drug Des Deliv 1989;5(2):167.

(76) Touitou E, Alhaique F, Riccieri FM, Riccioni G, Santucci E. Scleroglucan sustained-release oral preparations. Part I. In vitro experiments. Drug Des Deliv 1989;5(2):141-148.

(77) Sechter I, Touitou E, Donbrow M. The influence of a non-ionic surfactant on rectal absorption of virus particles. Arch Virol 1989;106(1-2):141-143.

(78) Borchardt RT, Mazer NA, Rytting JH, Shek E, Ziv E, Touitou E, et al. The delivery of peptides. J Pharm Sci 1989;78(11):883-892.

(79) Touitou E, Fabin B, Dany S, Almog S. Transdermal delivery of tetrahydrocannabinol. Int J Pharm 1988;43(1-2):9-15.

(80) Touitou E, Fabin B. Altered skin permeation of a highly lipophilic molecule: tetrahydrocannabinol. Int J Pharm 1988;43(1-2):17-22.

(81) Touitou E. Skin permeation enhancement by n-decyl methyl sulfoxide: effect of solvent systems and insights on mechanism of action. Int J Pharm 1988;43(1-2):1-7.

(82) Zbaida S, Touitou E. Skin permeation of chlorpheniramine maleate and detection of demethylated metabolites by high‐performance liquid chromatography. J Pharm Sci 1988;77(2):188-190.

(83) Touitou E. Permeability of young versus old skin. BIOENG SKIN 1988;4(1):67-74.

(84) Hemo I, Touitou E, Zauberman H. Promoting effect of n‐decylmethyl sulfoxide on the penetrability of the optic nerve for lidocaine HCI in cats. J Pharm Sci 1987;76(9):692-694.

(85) Touitou E, Alhaique F, Fisher P, Memoli A, Riccieri FM, Santucci E. Prevention of molecular self‐association by sodium salicylate: Effect on insulin and 6‐carboxyfluorescein. J Pharm Sci 1987;76(10):791-793.

(86) Touitou E, Menczel E. Transdermal therapeutics. Harefuah 1986;110(7):356-359.

(87) Touitou E. Transdermal delivery of anxiolytics: in vitro skin permeation of midazolam maleate and diazepam. Int J Pharm 1986;33(1-3):37-43.

(88) Touitou E, Fisher P. Prevention of molecular self‐association by sodium salicylate: Effect on methylene blue. J Pharm Sci 1986;75(4):384-386.

(89) Touitou E, Rubinstein A. Targeted enteral delivery of insulin to rats. Int J Pharm 1986;30(2-3):95-99.

(90) Touitou E, Abed L. Effect of propylene glycol, Azone and n-decylmethyl sulphoxide on skin permeation kinetics of 5-fluorouracil. Int J Pharm 1985;27(1):89-98.

(91) Touitou E, Abed L. The permeation behavior of several membranes with potential use in the design of transdermal devices. Pharm Acta Helv 1985;60(7):193-198.

(92) Touitou E, Yosselson‐Superstine S. THEOPHYLLINE VERSUS AMINOPHYLLINE IN RECTAL ADMINISTRATION. J Clin Pharm Ther 1985;10(2):211-217.

(93) Touitou E, Friedman D. The release mechanism of drags from polyurethane transdermal delivery systems. Int J Pharm 1984;19(3):323-332.

(94) Touitou E, Donbrow M. Promoted rectal absorption of insulin: formulative parameters involved in the absorption from hydrophilic bases. Int J Pharm 1983;15(1):13-24.

(95) Touitou E, Donbrow M. Drug release from non-disintegrating hydrophilic matrices: sodium salicylate as a model drug. Int J Pharm 1982;11(4):355-364.

(96) Touitou E, Donbrow M. Influence of additives on (hydroxyethyl) methylcellulose properties: relation between gelation temperature change, compressed matrix integrity and drug release profile. Int J Pharm 1982;11(2):131-148.

(97) Touitou E, Donbrow M. Deviation of dissolution behaviour of benzoic acid from theoretical predictions with lowering of temperature: limitations as a model dissolution substance. Int J Pharm 1981;9(2):97-106.

(98) TOUITOU E, DONBROW M, RUBINSTEIN A. Effective intestinal absorption of insulin in diabetic rats using a new formulation approach. J Pharm Pharmacol 1980;32(1):108-110.

(99) Kidron M, Eldor A, Lichtenberg D, Touitou E, Ziv E, Bar-On H. Enteral administration of heparin. Thromb Res 1979;16(5-6):833-835.

(100) Donbrow M, Touitou E. Estimation of dissolution rate of salicylamide in complexing media using a theoretical diffusion model. J Pharm Sci 1978;67(1):95-98.

(101) Donbrow M, Touítou E. NON‐DIFFUSIONAL DISSOLUTION BEHAVIOUR OF BENZOIC ACID. J Pharm Pharmacol 1977;29(1 S):3P-3P.

(102) DONBROW M, TOUITOU E. The dissolution mechanism in a system undergoing complexation: salicylamide in caffeine solution. J Pharm Pharmacol 1977;29(1):524-528.

(103) Donbrow M, Touitou E. Change of dissolution rate profile of salicylamide in caffeine complexing medium. J Pharm Pharmacol 1976;28(SUP.).

(104) Donbrow M, Touitou E, Shalom HB. Stability of salicylamide‐caffeine complex at different temperatures and its thermodynamic parameters. J Pharm Pharmacol 1976;28(10):766-769.