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School of Pharmacy : Yaka Rami

Researchers

 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Chiu W-, Kovacheva L, Musgrove RE, Arien-Zakay H, Koprich JB, Brotchie JM, et al. α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms. Sci Adv 2021;7(11).

(2) Thornton C, Grad E, Yaka R. The role of mitochondria in cocaine addiction. Biochem J 2021;478(4):749-764.

(3) Weitz M, Khayat A, Yaka R. GABAergic projections to the ventral tegmental area govern cocaine-conditioned reward. Addict Biol 2021.

(4) Bingor A, Azriel M, Amiad L, Yaka R. Potentiated Response of ERK/MAPK Signaling is Associated with Prolonged Withdrawal from Cocaine Behavioral Sensitization. J Mol Neurosci 2021.

(5) Bingor A, Haham T, Thornton C, Stern-Bach Y, Yaka R. Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors. Nat Commun 2020;11(1).

(6) Bingor A, Yaka R. Using toxins in brain slice recordings. Methods Mol Biol 2020;2068:269-274.

(7) Beiser T, Numa R, Kohen R, Yaka R. Chronic treatment with Tempol during acquisition or withdrawal from CPP abolishes the expression of cocaine reward and diminishes oxidative damage. Sci Rep 2017;7(1).

(8) Liraz-Zaltsman S, Yaka R, Shabashov D, Shohami E, Biegon A. Neuroinflammation-Induced Memory Deficits Are Amenable to Treatment with d-Cycloserine. J Mol Neurosci 2016;60(1):46-62.

(9) Poltyrev T, Yaka R. Influence of abstinence and intervals between extinction trials on the expression of cocaine-conditioned place preference in adolescent rats. Psychopharmacology 2013;226(4):699-706.

(10) Lecht S, Rotfeld E, Arien-Zakay H, Tabakman R, Matzner H, Yaka R, et al. Neuroprotective effects of nimodipine and nifedipine in the NGF-differentiated PC12 cells exposed to oxygen-glucose deprivation or trophic withdrawal. Int J Dev Neurosci 2012;30(6):465-469.

(11) Shabashov D, Shohami E, Yaka R. Inactivation of PKMζ in the NAc shell abolished cocaine-conditioned reward. J Mol Neurosci 2012;47(3):546-553.

(12) Michaeli A, Matzner H, Poltyrev T, Yaka R. Modifications of the input currents on VTA dopamine neurons following acute versus chronic cocaine exposure. Neuropharmacology 2012;62(4):1834-1840.

(13) Barnea-Ygael N, Yadid G, Yaka R, Ben-Shahar O, Zangen A. Cue-induced reinstatement of cocaine seeking in the rat "conflict model": Effect of prolonged home-cage confinement. Psychopharmacology 2012;219(3):875-883.

(14) Michaeli A, Yaka R. Dopamine-related drugs act presynaptically to potentiate GABA A receptor currents in VTA dopamine neurons. Neuropharmacology 2011;61(1-2):234-244.

(15) Liraz-Zaltsman S, Alexandrovich AG, Trembovler V, Fishbein I, Yaka R, Shohami E, et al. Regional sensitivity to neuroinflammation: In vivo and in vitro studies. Synapse 2011;65(7):634-642.

(16) Gibb SL, Jeanblanc J, Barak S, Yowell QV, Yaka R, Ron D. Lyn kinase regulates mesolimbic dopamine release: Implication for alcohol reward. J Neurosci 2011;31(6):2180-2187.

(17) Numa R, Baron M, Kohen R, Yaka R. Tempol attenuates cocaine-induced death of PC12 cells through decreased oxidative damage. Eur J Pharmacol 2011;650(1):157-162.

(18) Friedman A, Lax E, Dikshtein Y, Abraham L, Flaumenhaft Y, Sudai E, et al. Electrical stimulation of the lateral habenula produces enduring inhibitory effect on cocaine seeking behavior. Neuropharmacology 2010;59(6):452-459.

(19) Portugal-Cohen M, Numa R, Yaka R, Kohen R. Cocaine induces oxidative damage to skin via xanthine oxidase and nitric oxide synthase. J Dermatol Sci 2010;58(2):105-112.

(20) Adeleye A, Shohami E, Nachman D, Alexandrovich A, Trembovler V, Yaka R, et al. d-Cycloserine improves functional outcome after traumatic brain injury with wide therapeutic window. Eur J Pharmacol 2010;629(1-3):25-30.

(21) Michaeli A, Yaka R. Dopamine inhibits GABAA currents in ventral tegmental area dopamine neurons via activation of presynaptic G-protein coupled inwardly-rectifying potassium channels. Neuroscience 2010;165(4):1159-1169.

(22) Schumann J, Matzner H, Michaeli A, Yaka R. NR2A/B-containing NMDA receptors mediate cocaine-induced synaptic plasticity in the VTA and cocaine psychomotor sensitization. Neurosci Lett 2009;461(2):159-162.

(23) Schumann J, Yaka R. Prolonged withdrawal from repeated noncontingent cocaine exposure increases NMDA receptor expression and ERK activity in the nucleus accumbens. J Neurosci 2009;29(21):6955-6963.

(24) Parnas M, Katz B, Lev S, Tzarfaty V, Dadon D, Gordon-Shaag A, et al. Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels. J Neurosci 2009;29(8):2371-2383.

(25) Schumann J, Michaeli A, Yaka R. Src-protein tyrosine kinases are required for cocaine-induced increase in the expression and function of the NMDA receptor in the ventral tegmental area. J Neurochem 2009;108(3):697-706.

(26) Numa R, Kohen R, Poltyrev T, Yaka R. Tempol diminishes cocaine-induced oxidative damage and attenuates the development and expression of behavioral sensitization. Neuroscience 2008;155(3):649-658.

(27) Schumann J, Alexandrovich GA, Biegon A, Yaka R. Inhibition of NR2B phosphorylation restores alterations in NMDA receptor expression and improves functional recovery following traumatic brain injury in mice. J Neurotrauma 2008;25(8):945-957.

(28) Yaka R, Biegon A, Grigoriadis N, Simeonidou C, Grigoriadis S, Alexandrovich AG, et al. D-cycloserine improves functional recovery and reinstates long-term potentiation (LTP) in a mouse model of closed head injury. FASEB J 2007;21(9):2033-2041.

(29) Yaka R, Salomon S, Matzner H, Weinstock M. Effect of varied gestational stress on acquisition of spatial memory, hippocampal LTP and synaptic proteins in juvenile male rats. Behav Brain Res 2007;179(1):126-132.

(30) Schilström B, Yaka R, Argilli E, Suvarna N, Schumann J, Chen BT, et al. Erratum: Cocaine enhances NMDA receptor-mediated currents in ventral tegmental area cells via dopamine D5 receptor-dependent redistribution of NMDA receptors (Journal of Neuroscience (August 16, 2006) (8549-8558)). J Neurosci 2006;26(37):9604.

(31) Schilström B, Yaka R, Argilli E, Suvarna N, Schumann J, Chen BT, et al. Cocaine enhances NMDA receptor-mediated currents in ventral tegmental area cells via dopamine D5 receptor-dependent redistribution of NMDA receptors. J Neurosci 2006;26(33):8549-8558.

(32) Ashique AM, Kharazia V, Yaka R, Phamluong K, Peterson AS, Ron D. Localization of the scaffolding protein RACK1 in the developing and adult mouse brain. Brain Res 2006;1069(1):31-38.

(33) Thornton C, Tang K-, Phamluong K, Luong K, Vagts A, Nikanjam D, et al. Spatial and temporal regulation of RACK1 function and N-methyl-D-aspartate receptor activity through WD40 motif-mediated dimerization. J Biol Chem 2004;279(30):31357-31364.

(34) Yaka R, Tang K-, Camarini R, Janak PH, Ron D. Erratum: Fyn Kinase and NRB-Containing NMDA Receptors Regulate Acute Ethanol Sensitivity but not Ethanol Intake or Conditioned Reward (Alcoholism: Clinical and Experiment Research (November 2003)). Alcohol Clin Exp Res 2004;28(1):202.

(35) Yaka R, Tang K-, Camarini R, Janak PH, Ron D. Fyn Kinase and NR2B-Containing NMDA Receptors Regulate Acute Ethanol Sensitivity but Not Ethanol Intake or Conditioned Reward. Alcohol Clin Exp Res 2003;27(11):1736-1742.

(36) Vagts AJ, He D-, Yaka R, Ron D. Cellular Adaptation to Chronic Ethanol Results in Altered Compartmentalization and Function of the Scaffolding Protein RACK1. Alcohol Clin Exp Res 2003;27(10):1599-1605.

(37) Ungless MA, Singh V, Crowder TL, Yaka R, Ron D, Bonci A. Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons. Neuron 2003;39(3):401-407.

(38) Thornton C, Yaka R, Dinh S, Ron D. H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activity. J Biol Chem 2003;278(26):23823-23829.

(39) Yaka R, Phamluong K, Ron D. Scaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol. J Neurosci 2003;23(9):3623-3632.

(40) Yaka R, He D-, Phamluong K, Ron D. Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1. J Biol Chem 2003;278(11):9630-9638.

(41) He D-, Vagts AJ, Yaka R, Ron D. Ethanol induces gene expression via nuclear compartmentalization of receptor for activated C kinase 1. Mol Pharmacol 2002;62(2):272-280.

(42) Yaka R, Thornton C, Vagts AJ, Phamluong K, Bonci A, Ron D. NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1. Proc Natl Acad Sci U S A 2002;99(8):5710-5715.

(43) Yaka R, Notkin N, Yinon U, Wollberg Z. Visual, auditory and bimodal activity in the banks of the lateral suprasylvian sulcus in the cat. Neurosci Behav Physiol 2002;32(1):103-108.

(44) Yaka R, Yinon U, Rosner M, Wollberg Z. Erratum: Pathological and experimentally induced blindness induces auditory activity in the cat primary visual cortex (Experimental Brain Research (2000) 131 (144-148)). Exp Brain Res 2000;132(3):416.

(45) Yaka R, Yinon U, Rosner M, Wollberg Z. Erratum: Pathological and experimentally induced blindness induces auditory activity in the cat primary visual cortex. Exp Brain Res 2000;132(3):416.

(46) Yaka R, Notkin N, Yinon U, Wollberg Z. Visual, auditory, and bimodal activity in the banks of the lateral suprasylvian sulcus in the cat. Ross Fiziol Zh Im I M Sechenova 2000;86(7):877-883.

(47) Yaka R, Yinon U, Rosner M, Wollberg Z. Pathological and experimentally induced blindness induces auditory activity in the cat primary visual cortex. Exp Brain Res 2000;131(1):144-148.

(48) Dorit RON, Vagts AJ, Dohrman DP, Yaka R, Jiang Z, Yao L, et al. Uncoupling of βIIPKC from its targeting protein RACK1 in response to ethanol in cultured cells and mouse brain. FASEB J 2000;14(14):2303-2314.

(49) Yaka R, Yinon U, Wollberg Z. Auditory activation of cortical visual areas in cats after early visual deprivation. Eur J Neurosci 1999;11(4):1301-1312.

(50) Yaka R, Gamliel A, Gurwitz D, Stein R. NGF induces transient but not sustained activation of ERK in PC12 mutant cells incapable of differentiating. J Cell Biochem 1998;70(3):425-432.