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School of Pharmacy : Yavin Eylon

Researchers

 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Tepper O, Zheng H, Appella DH, Yavin E. Cyclopentane FIT-PNAs: Bright RNA sensors. Chem Commun 2021;57(4):540-543.

(2) Yavin E. Peptide nucleic acids: Applications in biomedical sciences. Molecules 2020;25(15).

(3) Maximov VV, Akkawi R, Khawaled S, Salah Z, Jaber L, Barhoum A, et al. MiR-16-1-3p and miR-16-2-3p possess strong tumor suppressive and antimetastatic properties in osteosarcoma. Int J Cancer 2019;145(11):3052-3063.

(4) Denichenko P, Mogilevsky M, Cléry A, Welte T, Biran J, Shimshon O, et al. Specific inhibition of splicing factor activity by decoy RNA oligonucleotides. Nat Commun 2019;10(1).

(5) Soudah T, Khawaled S, Aqeilan RI, Yavin E. AntimiR-155 Cyclic Peptide-PNA Conjugate: Synthesis, Cellular Uptake, and Biological Activity. ACS Omega 2019;4(9):13954-13961.

(6) Hashoul D, Shapira R, Falchenko M, Tepper O, Paviov V, Nissan A, et al. Red-emitting FIT-PNAs: “On site” detection of RNA biomarkers in fresh human cancer tissues. Biosens Bioelectron 2019;137:271-278.

(7) Mogilevsky M, Shimshon O, Kumar S, Mogilevsky A, Keshet E, Yavin E, et al. Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment. Nucleic Acids Res 2018;46(21):11396-11404.

(8) Tiram G, Ferber S, Ofek P, Eldar-Boock A, Ben-Shushan D, Yeini E, et al. Reverting the molecular fingerprint of tumor dormancy as a therapeutic strategy for glioblastoma. FASEB J 2018;32(11):5835-5850.

(9) Faust O, Grunhaus D, Shimshon O, Yavin E, Friedler A. Protein Regulation by Intrinsically Disordered Regions: A Role for Subdomains in the IDR of the HIV-1 Rev Protein. ChemBioChem 2018;19(15):1618-1624.

(10) Peled I, Yavin E. Predictive Model for the Sequence-Dependent Fluorogenic Response of Forced-Intercalation Peptide Nucleic Acid. ACS Omega 2018;3(4):3813-3818.

(11) Soudah T, Mogilevsky M, Karni R, Yavin E. CLIP6-PNA-Peptide Conjugates: Non-Endosomal Delivery of Splice Switching Oligonucleotides. Bioconjugate Chem 2017;28(12):3036-3042.

(12) Amsalem O, Nassar T, Benhamron S, Lazarovici P, Benita S, Yavin E. Solid nano-in-nanoparticles for potential delivery of siRNA. J Control Release 2017;257:144-155.

(13) Bloch MBD, Yavin E, Nissan A, Ariel I, Kenett R, Brass D, et al. The effect of linker type and recognition peptide conjugation chemistry on tissue affinity and cytotoxicity of charged polyacrylamide. J Control Release 2017;257:102-117.

(14) Kolevzon N, Hashoul D, Naik S, Rubinstein A, Yavin E. Single point mutation detection in living cancer cells by far-red emitting PNA-FIT probes. Chem Commun 2016;52(11):2405-2407.

(15) Shemesh Y, Yavin E. Postsynthetic Conjugation of RNA to Carboxylate and Dicarboxylate Molecules. Nucleosides Nucleotides Nucleic Acids 2015;34(11):753-762.

(16) Shemesh Y, Yavin E. PNA-rose bengal conjugates as efficient DNA photomodulators. Bioconjugate Chem 2015;26(9):1916-1922.

(17) Amit-Avraham I, Pozner G, Eshar S, Fastman Y, Kolevzon N, Yavin E, et al. Antisense long noncoding RNAs regulate var gene activation in the malaria parasite Plasmodium falciparum. Proc Natl Acad Sci U S A 2015;112(9):E982-E991.

(18) Wexselblatt E, Raveendran R, Salameh S, Friedman-Ezra A, Yavin E, Gibson D. On the stability of PtIV pro-drugs with haloacetato ligands in the axial positions. Chem Eur J 2015;21(7):3108-3114.

(19) Bloch M, Jablonowski L, Yavin E, Moradov D, Djavsarov I, Nyska A, et al. Multi-modal detection of colon malignancy by NIR-tagged recognition polymers and ultrasound contrast agents. Int J Pharm 2015;478(2):504-516.

(20) Bloch M, Kenett R, Jablonowski L, Wheatley M, Yavin E, Rubinstein A. A multifactorial analysis of complex pharmaceutical platforms: An application of design of experiments to targetable polyacrylamide and ultrasound contrast agents. Polym Adv Technol 2015;26(7):898-905.

(21) Kovaliov M, Wachtel C, Yavin E, Fischer B. Synthesis and evaluation of a photoresponsive quencher for fluorescent hybridization probes. Org Biomol Chem 2014;12(39):7844-7858.

(22) Kam Y, Rubinstein A, Naik S, Djavsarov I, Halle D, Ariel I, et al. Detection of a long non-coding RNA (CCAT1) in living cells and human adenocarcinoma of colon tissues using FIT-PNA molecular beacons. Cancer Lett 2014;352(1):90-96.

(23) Zilbershtein-Shklanovsky L, Kafri P, Shav-Tal Y, Yavin E, Fischer B. Development of fluorescent double-strand probes labeled with 8-(p-CF 3-cinnamyl)-adenosine for the detection of cyclin D1 breast cancer marker. Eur J Med Chem 2014;79:77-88.

(24) Kovaliov M, Segal M, Kafri P, Yavin E, Shav-Tal Y, Fischer B. Detection of cyclin D1 mRNA by hybridization sensitive NIC-oligonucleotide probe. Bioorg Med Chem 2014;22(9):2613-2621.

(25) Kolevzon N, Nasereddin A, Naik S, Yavin E, Dzikowski R. Use of peptide nucleic acids to manipulate gene expression in the malaria parasite Plasmodium falciparum. PLoS ONE 2014;9(1).

(26) Shekh-Ahmad T, Mawasi H, McDonough JH, Finnell RH, Wlodarczyk BJ, Yavin E, et al. Enantioselective pharmacodynamic and pharmacokinetic analysis of two chiral CNS-active carbamate derivatives of valproic acid. Epilepsia 2014;55(12):1944-1952.

(27) Khvalevsky EZ, Gabai R, Rachmut IH, Horwitz E, Brunschwig Z, Orbach A, et al. Mutant KRAS is a druggable target for pancreatic cancer. Proc Natl Acad Sci U S A 2013;110(51):20723-20728.

(28) Dahan-Pasternak N, Nasereddin A, Kolevzon N, Pe'er M, Wong W, Shinder V, et al. Pfsec13 is an unusual chromatin-associated nucleoporin of plasmodium falciparum that is essential for parasite proliferation in human erythrocytes. J Cell Sci 2013;126(14):3055-3069.

(29) Segal M, Yavin E, Kafri P, Shav-Tal Y, Fischer B. Detection of mRNA of the cyclin D1 breast cancer marker by a novel duplex-DNA probe. J Med Chem 2013;56(12):4860-4869.

(30) Wexselblatt E, Yavin E, Gibson D. Platinum(IV) prodrugs with haloacetato ligands in the axial positions can undergo hydrolysis under biologically relevant conditions. Angew Chem Int Ed 2013;52(23):6059-6062.

(31) Wexselblatt E, Kaspy I, Glaser G, Katzhendler J, Yavin E. Design, synthesis and structure-activity relationship of novel Relacin analogs as inhibitors of Rel proteins. Eur J Med Chem 2013;70:497-504.

(32) Bloch M, Kam Y, Yavin E, Moradov D, Nissan A, Ariel I, et al. The relative roles of charge and a recognition peptide in luminal targeting of colorectal cancer by fluorescent polyacrylamide. Eur J Pharm Sci 2012;47(5):904-913.

(33) Wexselblatt E, Yavin E, Gibson D. Cellular interactions of platinum drugs. Inorg Chim Acta 2012;393:75-83.

(34) Cohen G, Lecht S, Arien-Zakay H, Ettinger K, Amsalem O, Oron-Herman M, et al. Bio-Imaging of Colorectal Cancer Models Using Near Infrared Labeled Epidermal Growth Factor. PLoS ONE 2012;7(11).

(35) Wexselblatt E, Oppenheimer-Shaanan Y, Kaspy I, London N, Schueler-Furman O, Yavin E, et al. Relacin, a Novel Antibacterial Agent Targeting the Stringent Response. PLoS Pathog 2012;8(9).

(36) Kam Y, Rubinstein A, Nissan A, Halle D, Yavin E. Detection of endogenous K-ras mRNA in living cells at a single base resolution by a PNA molecular beacon. Mol Pharm 2012;9(3):685-693.

(37) Shekh-Ahmad T, Bialer M, Yavin E. Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue. Epilepsy Res 2012;98(2-3):238-246.

(38) Khazanov E, Yavin E, Pascal A, Nissan A, Kohl Y, Reimann-Zawadzki M, et al. Detecting a secreted gastric cancer biomarker molecule by targeted nanoparticles for real-time diagnostics. Pharm Res 2012;29(4):983-993.

(39) Kolevzon N, Kuflik U, Shmuel M, Benhamron S, Ringel I, Yavin E. Multiple triphenylphosphonium cations as a platform for the delivery of a pro-apoptotic peptide. Pharm Res 2011;28(11):2780-2789.

(40) Oppenheimer-Shaanan Y, Wexselblatt E, Katzhendler J, Yavin E, Ben-Yehuda S. C-di-AMP reports DNA integrity during sporulation in Bacillus subtilis. EMBO Rep 2011;12(6):594-601.

(41) Kolevzon N, Yavin E. Site-specific DNA photocleavage and photomodulation by oligonucleotide conjugates. Oligonucleotides 2010;20(6):263-275.

(42) Alkhader S, Ezra A, Kasparkova J, Brabec V, Yavin E. A metal-free DNA nuclease based on a cyclic peptide scaffold. Bioconjugate Chem 2010;21(8):1425-1431.

(43) Khazanov E, Emmanuel N, Azab AK, Barenholz Y, Yavin E, Rubinstein A. Specific detection of gastric α-antitrypsin by immobilized trypsin on PolyHEMA films. Mol Pharm 2010;7(4):944-952.

(44) Zobel E, Yavin E, Gottlieb HE, Segal M, Fischer B. Oligonucleotides are potent antioxidants acting primarily through metal ion chelation. J Biol Inorg Chem 2010;15(4):601-620.

(45) Biton A, Ezra A, Kasparkova J, Brabec V, Yavin E. DNA photocleavage by DNA and DNA-LNA amino acid-dye conjugates. Bioconjugate Chem 2010;21(4):616-621.

(46) Abu-Gosh SE, Kolvazon N, Tirosh B, Ringel I, Yavin E. Multiple triphenylphosphonium cations shuttle a hydrophilic peptide into mitochondria. Mol Pharm 2009;6(4):1138-1144.

(47) Boal AK, Yavin E, Barton JK. DNA repair glycosylases with a [4Fe-4S] cluster: A redox cofactor for DNA-mediated charge transport? J Inorg Biochem 2007;101(11-12):1913-1921.

(48) Gorodetsky AA, Green O, Yavin E, Barton JK. Coupling into the base pair stack is necessary for DNA-mediated electrochemistry. Bioconjugate Chem 2007;18(5):1434-1441.

(49) Yavin E, Stemp EDA, O'Shea VL, David SS, Barton JK. Electron trap for DNA-bound repair enzymes: A strategy for DNA-mediated signaling. Proc Natl Acad Sci U S A 2006;103(10):3610-3614.

(50) Yavin E, Kikkiri R, Gil S, Arad-Yellin R, Yavin E, Shanzer A. Synthesis and biological evaluation of lipophilic iron chelators as protective agents from oxidative stress. Org Biomol Chem 2005;3(15):2685-2687.

(51) Boal AK, Yavin E, Lukianova OA, O'Shea VL, David SS, Barton JK. DNA-bound redox activity of DNA repair glycosylases containing [4Fe-4S] clusters. Biochemistry 2005;44(23):8397-8407.

(52) Yavin E, Boal AK, Stemp EDA, Boon EM, Livingston AL, O'Shea VL, et al. Protein-DNA charge transport: Redox activation of a DNA repair protein by guanine radical. Proc Natl Acad Sci U S A 2005;102(10):3546-3551.

(53) Yavin E, Stemp EDA, Weiner L, Sagi I, Arad-Yellin R, Shanzer A. Direct photo-induced DNA strand scission by a ruthenium bipyridyl complex. J Inorg Biochem 2004;98(11):1750-1756.

(54) Yavin E, Weiner L, Arad-Yellin R, Shanzer A. Photoinduced electron transfer in Ruthenium bipyridyl complexes: Evidence for the existence of a cage with molecular oxygen. J Phys Chem A 2004;108(42):9274-9282.

(55) Yavin E, Weiner L, Arad-Yellin R, Shanzer A. Controlling the energy and electron transfer in a novel ruthenium bipyridyl complex: An ESR study. J Phys Chem A 2001;105(34):8018-8024.