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School of Pharmacy : Benhamou Raphael I.

Researchers

 Last updated August 2022 - School of Pharmacy

List of Publications

(1) Benhamou RI, Suresh BM, Tong Y, Cochrane WG, Cavett V, Vezina-Dawod S, et al. DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor. Proc Natl Acad Sci U S A 2022;119(6).

(2) Benhamou RI, Choudhary S, Lekah E, Tong Y, Disney MD. Bioinformatic Searching for Optimal RNA Targets of Dimeric Compounds Informs Design of a MicroRNA-27a Inhibitor. ACS Chem Biol 2022;17(1):5-10.

(3) Bush JA, Aikawa H, Fuerst R, Li Y, Ursu A, Meyer SM, et al. Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models. Sci Transl Med 2021;13(617).

(4) Zhang P, Liu X, Abegg D, Tanaka T, Tong Y, Benhamou RI, et al. Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment. J Am Chem Soc 2021;143(33):13044-13055.

(5) Bibi M, Murphy S, Benhamou RI, Rosenberg A, Ulman A, Bicanic T, et al. Combining Colistin and Fluconazole Synergistically Increases Fungal Membrane Permeability and Antifungal Cidality. ACS Infect Dis 2021;7(2):377-389.

(6) Angelbello AJ, Benhamou RI, Rzuczek SG, Choudhary S, Tang Z, Chen JL, et al. A Small Molecule that Binds an RNA Repeat Expansion Stimulates Its Decay via the Exosome Complex. Cell Chem Biol 2021;28(1):34-45.e6.

(7) Benhamou RI, Vezina-Dawod S, Choudhary S, Won Wang K, Meyer SM, Yildirim I, et al. Macrocyclization of a Ligand Targeting a Toxic RNA Dramatically Improves Potency. ChemBioChem 2020;21(22):3229-3233.

(8) Haniff HS, Tong Y, Liu X, Chen JL, Suresh BM, Andrews RJ, et al. Targeting the SARS-COV-2 RNA genome with small molecule binders and ribonuclease targeting chimera (RiboTAC) degraders. ACS Cent Sci 2020;6(10):1713-1721.

(9) Benhamou RI, Abe M, Choudhary S, Meyer SM, Angelbello AJ, Disney MD. Optimization of the Linker Domain in a Dimeric Compound that Degrades an r(CUG) Repeat Expansion in Cells. J Med Chem 2020;63(14):7827-7839.

(10) Disney MD, Suresh BM, Benhamou RI, Childs-Disney JL. Progress toward the development of the small molecule equivalent of small interfering RNA. Curr Opin Chem Biol 2020;56:63-71.

(11) Benhamou RI, Angelbello AJ, Andrews RJ, Wang ET, Moss WN, Disney MD. Structure-Specific Cleavage of an RNA Repeat Expansion with a Dimeric Small Molecule Is Advantageous over Sequence-Specific Recognition by an Oligonucleotide. ACS Chem Biol 2020;15(2):485-493.

(12) Benhamou RI, Angelbello AJ, Wang ET, Disney MD. A Toxic RNA Catalyzes the Cellular Synthesis of Its Own Inhibitor, Shunting It to Endogenous Decay Pathways. Cell Chem Biol 2020;27(2):223-231.e4.

(13) Elias R, Benhamou RI, Jaber QZ, Dorot O, Zada SL, Oved K, et al. Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. Eur J Med Chem 2019;179:779-790.

(14) Benhamou RI, Jaber QZ, Herzog IM, Roichman Y, Fridman M. Fluorescent Tracking of the Endoplasmic Reticulum in Live Pathogenic Fungal Cells. ACS Chem Biol 2018;13(12):3325-3332.

(15) Jaber QZ, Benhamou RI, Herzog IM, Ben Baruch B, Fridman M. Cationic Amphiphiles Induce Macromolecule Denaturation and Organelle Decomposition in Pathogenic Yeast. Angew Chem Int Ed 2018;57(50):16391-16395.

(16) Kim D, Liu Y, Benhamou RI, Sanchez H, Simon-Soro A, Li Y, et al. Bacterial-derived exopolysaccharides enhance antifungal drug tolerance in a cross-kingdom oral biofilm. ISME J 2018;12(6):1427-1442.

(17) Benhamou RI, Bibi M, Berman J, Fridman M. Localizing Antifungal Drugs to the Correct Organelle Can Markedly Enhance their Efficacy. Angew Chem Int Ed 2018;57(21):6230-6235.

(18) Steinbuch KB, Benhamou RI, Levin L, Stein R, Fridman M. Increased Degree of Unsaturation in the Lipid of Antifungal Cationic Amphiphiles Facilitates Selective Fungal Cell Disruption. ACS Infect Dis 2018;4(5):825-836.

(19) Salta J, Benhamou RI, Herzog IM, Fridman M. Tuning the Effects of Bacterial Membrane Permeability through Photo-Isomerization of Antimicrobial Cationic Amphiphiles. Chem Eur J 2017;23(52):12724-12728.

(20) Matzov D, Eyal Z, Benhamou RI, Shalev-Benami M, Halfon Y, Krupkin M, et al. Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus. Nucleic Acids Res 2017;45(17):10284-10292.

(21) Benhamou RI, Bibi M, Steinbuch KB, Engel H, Levin M, Roichman Y, et al. Real-Time Imaging of the Azole Class of Antifungal Drugs in Live Candida Cells. ACS Chem Biol 2017;12(7):1769-1777.

(22) Benhamou RI, Steinbuch KB, Fridman M. Antifungal Imidazole-Decorated Cationic Amphiphiles with Markedly Low Hemolytic Activity. Chem Eur J 2016;22(32):11148-11151.

(23) Shaul P, Benhamou RI, Herzog IM, Louzoun Zada S, Ebenstein Y, Fridman M. Synthesis and evaluation of membrane permeabilizing properties of cationic amphiphiles derived from the disaccharide trehalose. Org Biomol Chem 2016;14(11):3012-3015.

(24) Benhamou RI, Shaul P, Herzog IM, Fridman M. Di-N-Methylation of Anti-Gram-Positive Aminoglycoside-Derived Membrane Disruptors Improves Antimicrobial Potency and Broadens Spectrum to Gram-Negative Bacteria. Angew Chem Int Ed 2015;54(46):13617-13621.

(25) Berkov-Zrihen Y, Herzog IM, Benhamou RI, Feldman M, Steinbuch KB, Shaul P, et al. Tobramycin and nebramine as pseudo-oligosaccharide scaffolds for the development of antimicrobial cationic amphiphiles. Chem Eur J 2015;21(11):4340-4349.