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The Faculty of Medicine - Microbiology and Molecular Genetics: Adar Sheera

Researchers

Last updated February 2023 - Microbiology and Molecular Genetics

List of Publications

(1) Blessing C, Apelt K, van den Heuvel D, Gonzalez-Leal C, Rother MB, van der Woude M, et al. XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair. Nat Commun 2022;13(1).

(2) Nasereddin A, Berman HG, Wolf DG, Oiknine-Djian E, Adar S. Identification of SARS-CoV-2 Variants of Concern Using Amplicon Next-Generation Sequencing. Microbiol Spectr 2022;10(4).

(3) Alfi O, Hamdan M, Wald O, Yakirevitch A, Wandel O, Oiknine-Djian E, et al. SARS-CoV-2 Omicron Induces Enhanced Mucosal Interferon Response Compared to other Variants of Concern, Associated with Restricted Replication in Human Lung Tissues. Viruses 2022;14(7).

(4) Douki T, Adar S. CHAPTER 7: Ultraviolet-induced Formation of DNA Damage in Cells and their Mutational Consequences. Compr Ser Photochem Photobiol Sci 2022;2022-January(21):133-163.

(5) Wegner F, Roloff T, Huber M, Cordey S, Ramette A, Gerth Y, et al. External Quality Assessment of SARS-CoV-2 Sequencing: an ESGMD-SSM Pilot Trial across 15 European Laboratories. J Clin Microbiol 2022;60(1).

(6) Yaacov A, Vardi O, Blumenfeld B, Greenberg A, Massey DJ, Koren A, et al. Cancer Mutational Processes Vary in Their Association with Replication Timing and Chromatin Accessibility. Cancer Res 2021;81(24):6106-6116.

(7) Berman HG, Chauhan P, Shalev S, Hassanain H, Parnas A, Adar S. Genomic characterization of cisplatin response uncovers priming of cisplatin-induced genes in a resistant cell line. Int J Mol Sci 2021;22(11).

(8) Heilbrun EE, Merav M, Adar S. Exons and introns exhibit transcriptional strand asymmetry of dinucleotide distribution, damage formation and DNA repair. NAR Genom Bioinform 2021;3(1).

(9) van der Weegen Y, Golan-Berman H, Mevissen TET, Apelt K, González-Prieto R, Goedhart J, et al. Publisher Correction: The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II (Nature Communications, (2020), 11, 1, (2104), 10.1038/s41467-020-15903-8). Nat Commun 2020;11(1).

(10) van der Weegen Y, Golan-Berman H, Mevissen TET, Apelt K, González-Prieto R, Goedhart J, et al. The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II. Nat Commun 2020;11(1).

(11) Heilbrun EE, Merav M, Parnas A, Adar S. The hardwired transcriptional response to DNA damage. Curr Opin Syst 2020;19:1-7.

(12) Milo-Cochavi S, Adar S, Covo S. Developmentally regulated oscillations in the expression of uv repair genes in a soilborne plant pathogen dictate UV repair efficiency and survival. mBio 2019;10(6).

(13) Hu J, Selby CP, Adar S, Adebali O, Sancar A. Molecular mechanisms and genomic maps of DNA excision repair in Escherichia coli and humans. J Biol Chem 2017;292(38):15588-15597.

(14) Li W, Hu J, Adebali O, Adar S, Yang Y, Chiou Y-, et al. Human genome-wide repair map of DNA damage caused by the cigarette smoke carcinogen benzo[a]pyrene. Proc Natl Acad Sci U S A 2017;114(26):6752-6757.

(15) Hu J, Adebali O, Adar S, Sancar A. Dynamic maps of UV damage formation and repair for the human genome. Proc Natl Acad Sci U S A 2017;114(26):6758-6763.

(16) Hu J, Adar S. The Cartography of UV-induced DNA Damage Formation and DNA Repair. Photochem Photobiol 2017;93(1):199-206.

(17) Hu J, Lieb JD, Sancar A, Adar S. Cisplatin DNA damage and repair maps of the human genome at single-nucleotide resolution. Proc Natl Acad Sci U S A 2016;113(41):11507-11512.

(18) Adar S, Hu J, Lieb JD, Sancar A. Genome-wide kinetics of DNA excision repair in relation to chromatin state and mutagenesis. Proc Natl Acad Sci U S A 2016;113(15):E2124-E2133.

(19) Hu J, Adar S, Selby CP, Lieb JD, Sancar A. Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution. Genes Dev 2015;29(9):948-960.

(20) Annayev Y, Adar S, Chiou Y-, Lieb JD, Sancar A, Ye R. Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. J Biol Chem 2014;289(8):5013-5024.

(21) Dunham I, Kundaje A, Aldred SF, Collins PJ, Davis CA, Doyle F, et al. An integrated encyclopedia of DNA elements in the human genome. Nature 2012;489(7414):57-74.

(22) Adar S, Izhar L, Hendel A, Geacintov N, Livneh Z. Repair of gaps opposite lesions by homologous recombination in mammalian cells. Nucleic Acids Res 2009;37(17):5737-5748.

(23) Shachar S, Ziv O, Avkin S, Adar S, Wittschieben J, Reiner T, et al. Erratum: Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals (The EMBO Journal (2009) 28 (992) DOI: 10.1038/emboj.2009.72). EMBO J 2009;28(7):992.

(24) Shachar S, Ziv O, Avkin S, Adar S, Wittschieben J, Reißner T, et al. Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals. EMBO J 2009;28(4):383-393.

(25) Adar S, Livneh Z. Translesion DNA synthesis across non-DNA segments in cultured human cells. DNA Repair 2006;5(4):479-490.

(26) Avkin S, Adar S, Blander G, Livneh Z. Quantitative measurement of translesion replication in human cells: Evidence for bypass of abasic sites by a replicative DNA polymerase. Proc Natl Acad Sci U S A 2002;99(6):3764-3769.