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The Faculty of Medicine - Microbiology and Molecular Genetics: Altuvia Shoshy


 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Basu P, Elgrably-Weiss M, Hassouna F, Kumar M, Wiener R, Altuvia S. RNA binding of Hfq monomers promotes RelA-mediated hexamerization in a limiting Hfq environment. Nat Commun 2021;12(1).

(2) Ben-Zvi T, Pushkarev A, Seri H, Elgrably-Weiss M, Papenfort K, Altuvia S. mRNA dynamics and alternative conformations adopted under low and high arginine concentrations control polyamine biosynthesis in Salmonella. PLoS Genet 2019;15(2).

(3) Altuvia S, Storz G, Papenfort K. Cross-regulation between bacteria and phages at a posttranscriptional level. Microbiol Spectr 2018;6(4):1-14.

(4) Barshishat S, Elgrably-Weiss M, Edelstein J, Georg J, Govindarajan S, Haviv M, et al. OxyS small RNA induces cell cycle arrest to allow DNA damage repair. EMBO J 2018;37(3):413-426.

(5) Hershko-Shalev T, Odenheimer-Bergman A, Elgrably-Weiss M, Ben-Zvi T, Govindarajan S, Seri H, et al. Gifsy-1 Prophage IsrK with Dual Function as Small and Messenger RNA Modulates Vital Bacterial Machineries. PLoS Genet 2016;12(4).

(6) Nechooshtan G, Elgrably-Weiss M, Altuvia S. Changes in transcriptional pausing modify the folding dynamics of the pH-responsive RNA element. Nucleic Acids Res 2014;42(1):622-630.

(7) Argaman L, Elgrably-Weiss M, Hershko T, Vogel J, Altuvia S. RelA protein stimulates the activity of RyhB small RNA by acting on RNA-binding protein Hfq. Proc Natl Acad Sci U S A 2012;109(12):4621-4626.

(8) Nechooshtan G, Elgrably-Weiss M, Sheaffer A, Westhof E, Altuvia S. A pH-responsive riboregulator. Genes Dev 2009;23(22):2650-2662.

(9) Shimoni Y, Altuvia S, Margalit H, Biham O. Stochastic analysis of the SOS response in Escherichia coli. PLoS ONE 2009;4(5).

(10) Shifrin Y, Peleg A, Ilan O, Nadler C, Kobi S, Baruch K, et al. Transient shielding of intimin and the type III secretion system of enterohemorrhagic and enteropathogenic Escherichia coli by a group 4 capsule. J Bacteriol 2008;190(14):5063-5074.

(11) Padalon-Brauch G, Hershberg R, Elgrably-Weiss M, Baruch K, Rosenshine I, Margalit H, et al. Small RNAs encoded within genetic islands of Salmonella typhimurium show host-induced expression and role in virulence. Nucleic Acids Res 2008;36(6):1913-1927.

(12) Shimoni Y, Friedlander G, Hetzroni G, Niv G, Altuvia S, Biham O, et al. Regulation of gene expression by small non-coding RNAs: A quantitative view. Mol Syst Biol 2007;3.

(13) Altuvia S. Identification of bacterial small non-coding RNAs: experimental approaches. Curr Opin Microbiol 2007;10(3):257-261.

(14) Weinstein-Fischer D, Altuvia S. Differential regulation of Escherichia coli topoisomerase I by Fis. Mol Microbiol 2007;63(4):1131-1144.

(15) Elgrably-Weiss M, Schlosser-Silverman E, Rosenshine I, Altuvia S. DeoT, a DeoR-type transcriptional regulator of multiple target genes. FEMS Microbiol Lett 2006;254(1):141-148.

(16) Peleg A, Shifrin Y, Ilan O, Nadler-Yona C, Nov S, Koby S, et al. Identification of an Escherichia coli operon required for formation of the O-antigen capsule. J Bacteriol 2005;187(15):5259-5266.

(17) Storz G, Altuvia S, Wassarman KM. An abundance of RNA regulators. Annu Rev Biochem 2005;74:199-217.

(18) Vogel J, Argaman L, Wagner EGH, Altuvia S. The small RNA istR inhibits synthesis of an SOS-induced toxic peptide. Curr Biol 2004;14(24):2271-2276.

(19) Altuvia S. Regulatory small RNAs: The key to coordinating global regulatory circuits. J Bacteriol 2004;186(20):6679-6680.

(20) Qimron U, Madar N, Ascarelli-Goell R, Elgrably-Weiss M, Altuvia S, Porgador A. Reliable determination of transposon insertion site in prokaryotes by direct sequencing. J Microbiol Methods 2003;54(1):137-140.

(21) Hershberg R, Altuvia S, Margalit H. A survey of small RNA-encoding genes in Escherichia coli. Nucleic Acids Res 2003;31(7):1813-1820.

(22) Elgrably-Weiss M, Park S, Schlosser-Silverman E, Rosenshine I, Imlay J, Altuvia S. A Salmonella enterica serovar Typhimurium hemA mutant is highly susceptible to oxidative DNA damage. J Bacteriol 2002;184(14):3774-3784.

(23) Wagner EGH, Altuvia S, Romby P. 12 Antisense RNAs in bacteria and their genetic elements. Adv Genet 2002;46:361-398.

(24) Argaman L, Hershberg R, Vogel J, Bejerano G, Wagner EGH, Margalit H, et al. Novel small RNA-encoding genes in the intergenic regions of Escherichia coli. Curr Biol 2001;11(12):941-950.

(25) Schlosser-Silverman E, Elgrably-Weiss M, Rosenshine I, Kohen R, Altuvia S. Characterization of Escherichia coli DNA lesions generated within J774 macrophages. J Bacteriol 2000;182(18):5225-5230.

(26) Altuvia S, Wagner EGH. Switching on and off with RNA. Proc Natl Acad Sci U S A 2000;97(18):9824-9826.

(27) Argaman L, Altuvia S. fhlA repression by OxyS RNA: Kissing complex formation at two sites results in a stable antisense-target RNA complex. J Mol Biol 2000;300(5):1101-1112.

(28) Weinstein-Fischer D, Elgrably-Weiss M, Altuvia S. Escherichia coli response to hydrogen peroxide: A role for DNA supercoiling, Topoisomerase I and Fis. Mol Microbiol 2000;35(6):1413-1420.

(29) Altuvia S, Zhang A, Argaman L, Tiwari A, Storz G. The Escherichia coli OxyS regulatory RNA represses fhlA translation by blocking ribosome binding. EMBO J 1998;17(20):6069-6075.

(30) Zhang A, Altuvia S, Tiwari A, Argaman L, Hengge-Aronis R, Storz G. The OxyS regulatory RNA represses rpoS translation and binds the Hfq (HF-I) protein. EMBO J 1998;17(20):6061-6068.

(31) Altuvia S, Weinstein-Fischer D, Zhang A, Postow L, Storz G. A small, stable RNA induced by oxidative stress: Role as a pleiotropic regulator and antimutator. Cell 1997;90(1):43-53.

(32) Zhang A, Altuvia S, Storz G. The novel oxyS RNA regulates expression of the sigma s subunit of Escherichia coli RNA polymerase. Nucleic Acids Symp Ser 1997(36):27-28.

(33) Muffler A, Fischer D, Altuvia S, Storz G, Hengge-Aronis R. The response regulator RssB controls stability of the σS subunit of RNA polymerase in Escherichia coli. EMBO J 1996;15(6):1333-1339.

(34) Storz G, Zheng M, Zhang A, Kullik I, Toledano M, Altuvia S. The bacterial response to oxidative stress: regulation by a redox sensitive transcription factor and a regulatory RNA. Biochem Soc Trans 1996;24(4).

(35) Storz G, Altuvia S. OxyR regulon. Methods Enzymol 1994;234(C):217-223.

(36) Altuvia S, Almiron M, Huisman G, Kolter R, Storz G. The dps promoter is activated by OxyR during growth and by IHF and σs in stationary phase. Mol Microbiol 1994;13(2):265-272.

(37) Altuvia S, Stein WD, Goldenberg S, Kane SE, Pastan I, Gottesman MM. Targeted disruption of the mouse mdr1b gene reveals that steroid hormones enhance mdr gene expression. J Biol Chem 1993;268(36):27127-27132.

(38) Oppenheim AB, Kornitzer D, Altuvia S, Court DL. Posttranscriptional Control of the Lysogenic Pathway in Bacteriophage Lambda. Prog Nucleic Acid Res Mol Biol 1993;46(C):37-49.

(39) Kornitzer D, Altuvia S, Oppenheim AB. The activity of the CIII regulator of lambdoid bacteriophages resides within a 24-amino acid protein domain. Proc Natl Acad Sci U S A 1991;88(12):5217-5221.

(40) Altuvia S, Kornitzer D, Kobi S, Oppenheim AB. Functional and structural elements of the mRNA of the cIII gene of bacteriophage lambda. J Mol Biol 1991;218(4):723-733.

(41) Kornitzer D, Altuvia S, Oppenheim AB. Genetic analysis of the cIII gene of bacteriophage HK022. J Bacteriol 1991;173(2):810-815.

(42) Kornitzer D, Teff D, Altuvia S, Oppenheim AB. Isolation, characterization, and sequence of an Escherichia coli heat shock gene, htpX. J Bacteriol 1991;173(9):2944-2953.

(43) Oppenheim A, Altuvia S, Kornitzer D, Teff D, Koby S. Translation control of gene expression. J Basic Clin Physiol Pharmacol 1991;2(3):223-232.

(44) Altuvia S, Kornitzer D, Teff D, Oppenheim AB. Alternative mRNA structures of the cIII gene of bacteriophage λ determine the rate of its translation initiation. J Mol Biol 1989;210(2):265-280.

(45) Kornitzer D, Teff D, Altuvia S, Oppenheim AB. Genetic analysis of bacteriophage lambda cIII gene: mRNA structural requirements for translation initiation. J Bacteriol 1989;171(5):2563-2572.

(46) Suissa M, Altuvia S, Koby S, Giladi H, Oppenheim AB. Translational signals of a major head protein gene of bacteriophage lambda. Mol Gen Genet 1988;214(3):570-573.

(47) Altuvia S, Locker-Giladi H, Koby S, Ben-Nun O, Oppenheim AB. RNase III stimulates the translation of the cIII gene of bacteriophage lambda. Proc Natl Acad Sci U S A 1987;84(18):6511-6515.

(48) Altuvia S, Oppenheim AB. Translational regulatory signals within the coding region of the bacteriophage λ cIII gene. J Bacteriol 1986;167(1):415-419.

(49) Honigman A, Mahajna J, Altuvia S, Koby S, Teff D, Locker-Giladi H, et al. Plasmid vectors designed for the analysis of transcription termination signals. Gene 1985;36(1-2):131-141.

(50) Rattray A, Altuvia S, Mahajna G, Oppenheim AB, Gottesman M. Control of bacteriophage lambda cII activity by bacteriophage and host functions. J Bacteriol 1984;159(1):238-242.

(51) Oppenheim AB, Mahajna G, Koby S, Altuvia S. Regulation of the establishment of repressor synthesis in bacteriophage λ. J Mol Biol 1982;155(2):121-132.