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The Faculty of Medicine - Microbiology and Molecular Genetics: Hanski Emanuel


 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Sharma A, Sanduja P, Anand A, Mahajan P, Guzman CA, Yadav P, et al. Advanced strategies for development of vaccines against human bacterial pathogens. World J Microbiol Biotechnol 2021;37(4).

(2) Biswas D, Ambalavanan P, Ravins M, Anand A, Sharma A, Lim KXZ, et al. LL-37-mediated activation of host receptors is critical for defense against group A streptococcal infection. Cell Rep 2021;34(9).

(3) Sanduja P, Gupta M, Somani VK, Yadav V, Dua M, Hanski E, et al. Cross-serotype protection against group A Streptococcal infections induced by immunization with SPy_2191. Nat Commun 2020;11(1).

(4) Vajjala A, Biswas D, Tay WH, Hanski E, Kline KA. Streptolysin-induced endoplasmic reticulum stress promotes group A Streptococcal host-associated biofilm formation and necrotising fasciitis. Cell Microbiol 2019;21(1).

(5) Jobichen C, Tan YC, Prabhakar MT, Nayak D, Biswas D, Pannu NS, et al. Structure of ScpC, a virulence protease from Streptococcus pyogenes, reveals the functional domains and maturation mechanism. Biochem J 2018;475(17):2847-2860.

(6) Hertzog BB, Kaufman Y, Biswas D, Ravins M, Ambalavanan P, Wiener R, et al. A Sub-population of Group A Streptococcus Elicits a Population-wide Production of Bacteriocins to Establish Dominance in the Host. Cell Host and Microbe 2018;23(3):312-323.e6.

(7) Chee JLY, Ravins M, Hanski E, Chen SL. Complete genome sequence of Streptococcus pyogenes emm14 JS95, a necrotizing fasciitis strain isolated in Israel. Genome Announce 2017;5(11).

(8) Baruch M, Belotserkovsky I, Hertzog BB, Ravins M, Dov E, McIver KS, et al. Erratum: An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation (Cell (2014) 156 (97-108)). Cell 2014;156(3):617.

(9) Baruch M, Hertzog BB, Ravins M, Youting CC, Hanski E. Group A streptococcus and host metabolism: Virulence influences and potential treatments. Future Microbiol 2014;9(6):713-716.

(10) Baruch M, Hertzog BB, Ravins M, Anand A, Cheng CY, Biswas D, et al. Induction of endoplasmic reticulum stress and unfolded protein response constitutes a pathogenic strategy of group A streptococcus. Front Cell Infect Microbiol 2014;4(AUG).

(11) Plainvert C, Dinis M, Ravins M, Hanski E, Touak G, Dmytruk N, et al. Molecular epidemiology of sil locus in clinical streptococcus pyogenes strains. J Clin Microbiol 2014;52(6):2003-2010.

(12) Baruch M, Belotserkovsky I, Hertzog BB, Ravins M, Dov E, McIver KS, et al. An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation. Cell 2014;156(1-2):97-108.

(13) Mishalian I, Ordan M, Peled A, Maly A, Eichenbaum MB, Ravins M, et al. Recruited macrophages control dissemination of group A Streptococcus from infected soft tissues. J Immunol 2011;187(11):6022-6031.

(14) Kaur SJ, Nerlich A, Bergmann S, Rohde M, Fulde M, Zähner D, et al. The CXC chemokine-degrading protease SpyCep of Streptococcus pyogenes promotes its uptake into endothelial cells. J Biol Chem 2010;285(36):27798-27805.

(15) Mishalian I, Ravins M, Baruch M, Persky M, Belotserkovsky I, Hanski E. Host-Pathogen Relationship in Skin and Soft Tissue Infections Caused by Group A streptococcus and Staphylococcus aureus. Bacterial Virulence: Basic Principles, Models and Global Approaches; 2010. p. 43-68.

(16) Belotserkovsky L, Baruch M, Peer A, Dov E, Ravins M, Mishalian I, et al. Functional analysis of the quorum-sensing streptococcal invasion locus ( sil). PLoS Pathog 2009;5(11).

(17) Zinkernagel AS, Timmer AM, Pence MA, Locke JB, Buchanan JT, Turner CE, et al. The IL-8 Protease SpyCEP/ScpC of Group A Streptococcus Promotes Resistance to Neutrophil Killing. Cell Host and Microbe 2008;4(2):170-178.

(18) Eran Y, Getter Y, Baruch M, Belotserkovsky I, Padalon G, Mishalian I, et al. Transcriptional regulation of the sil locus by the SilCR signalling peptide and its implications on group A streptococcus virulence. Mol Microbiol 2007;63(4):1209-1222.

(19) Hidalgo-Grass C, Mishalian I, Dan-Goor M, Belotserkovsky I, Eran Y, Nizet V, et al. A streptococcal protease that degrades CXC chemokines and impairs bacterial clearance from infected tissues. EMBO J 2006;25(19):4628-4637.

(20) Lembke C, Podbielski A, Hidalgo-Grass C, Jonas L, Hanski E, Kreikemeyer B. Characterization of biofilm formation by clinically relevant serotypes of group A streptococci. Appl Environ Microbiol 2006;72(4):2864-2875.

(21) Hidalgo-Grass C, Dan-Goor M, Maly A, Eran Y, Kwinn LA, Nizet V, et al. Effect of a bacterial pheromone peptide on host chemokine degradation in group A streptococcal necrotising soft-tissue infections. Lancet 2004;363(9410):696-703.

(22) Tu X, Nisan I, Yona C, Hanski E, Rosenshine I. EspH, a new cytoskeleton-modulating effector of enterohaemorrhagic and enteropathogenic Escherichia coli. Mol Microbiol 2003;47(3):595-606.

(23) Hidalgo-Grass C, Ravins M, Dan-Goor M, Jaffe J, Moses AE, Hanski E. A locus of group A streptococcus involved in invasive disease and DNA transfer. Mol Microbiol 2002;46(1):87-99.

(24) Valinsky L, Nisan I, Tu X, Nisan G, Rosenshine I, Hanski E, et al. A host-specific virulence protein of Erwinia herbicola pv. gypsophilae is translocated into human epithelial cells by the type III secretion system of enteropathogenic Escherichia coli. Mol Plant Pathol 2002;3(2):97-101.

(25) Moses AE, Goldberg S, Korenman Z, Ravins M, Hanski E, Shapiro M. Invasive group A streptococcal infections, Israel. Emerg Infect Dis 2002;8(4):421-426.

(26) Tu X, Nisan I, Miller JF, Hanski E, Rosenshine I. Construction of mini-Tn5cyaA′ and its utilization for the identification of genes encoding surface-exposed and secreted proteins in Bordetella bronchiseptica. FEMS Microbiol Lett 2001;205(1):119-123.

(27) Ensenberger MG, Tomasini-Johansson BR, Sottile J, Ozeri V, Hanski E, Mosher DF. Specific Interactions between F1 Adhesin of Streptococcus pyogenes and N-terminal Modules of Fibronectin. J Biol Chem 2001;276(38):35606-35613.

(28) Ozeri V, Rosenshine I, Ben-Ze'Ev A, Bokoch GM, Jou T-, Hanski E. De novo formation of focal complex-like structures in host cells by invading streptococci. Mol Microbiol 2001;41(3):561-573.

(29) Tomasini-Johansson BR, Kaufman NR, Ensenberger MG, Ozeri V, Hanski E, Mosher DF. A 49-Residue Peptide from Adhesin F1 of Streptococcus pyogenes Inhibits Fibronectin Matrix Assembly. J Biol Chem 2001;276(26):23430-23439.

(30) Ravins M, Jaffe J, Hanski E, Shetzigovski I, Natanson-Yaron S, Moses AE. Characterization of a mouse-passaged, highly encapsulated variant of group A streptococcus in in vitro and in vivo studies. J Infect Dis 2000;182(6):1702-1711.

(31) Berkower C, Ravins M, Moses AE, Hanski E. Expression of different group A streptococcal M proteins in an isogenic background demonstrates diversity in adherence to and invasion of eukaryotic cells. Mol Microbiol 1999;31(5):1463-1475.

(32) Bejerano M, Nisan I, Ludwig A, Goebel W, Hanski E. Characterization of the C-terminal domain essential for toxic activity of adenylate cyclase toxin. Mol Microbiol 1999;31(1):381-392.

(33) Ozeri V, Rosenshine I, Mosher DF, Fässler R, Hanski E. Roles of integrins and fibronectin in the entry of Streptococcus pyogenes into cells via protein F1. Mol Microbiol 1998;30(3):625-637.

(34) Wolff C, Nisan I, Hanski E, Frankel G, Rosenshine I. Protein translocation into host epithelial cells by infecting enteropathogenic Escherichia coli. Mol Microbiol 1998;28(1):143-155.

(35) Nisan I, Wolff C, Hanski E, Rosenshine I. Interaction of Enteropathogenic Escherichia coli with Host Epithelial Cells. Folia Microbiol 1998;43(3):247-252.

(36) Okada N, Tatsuno I, Hanski E, Caparon M, Sasakawa C. Streptococcus pyogenes protein F promotes invasion of HeLa cells. Microbiology 1998;144(11):3079-3086.

(37) Jadoun J, Ozeri V, Burstein E, Skutelsky E, Hanski E, Sela S. Protein F1 is required for efficient entry of Streptococcus pyogenes into epithelial cells. J Infect Dis 1998;178(1):147-148.

(38) Ben-Ami G, Ozeri V, Hanski E, Hofmann F, Aktories K, Hahn KM, et al. Agents that inhibit Rho, Rac, and Cdc42 do not block formation of actin pedestals in HeLa cells infected with enteropathogenic Escherichia coli. Infect Immun 1998;66(4):1755-1758.

(39) Okada N, Watarai M, Ozeri V, Hanski E, Caparon M, Sasakawa C. A matrix form of fibronectin mediates enhanced binding of Streptococcus pyogenes to host tissue. J Biol Chem 1997;272(43):26978-26984.

(40) Jadoun J, Burstein E, Hanski E, Sela S. Proteins M6 and F1 are required for efficient invasion of Group A streptococci into cultured epithelial cells. ADV EXP MED BIOL 1997;418:511-515.

(41) Moses AE, Wessels MR, Zalcman K, Albertí S, Natanson-Yaron S, Menes T, et al. Relative contributions of hyaluronic acid capsule and M protein to virulence in a mucoid strain of the group A Streptococcus. Infect Immun 1997;65(1):64-71.

(42) Ozeri V, Tovi A, Burstein I, Natanson-Yaron S, Caparon MG, Yamada KM, et al. A two-domain mechanism for group A streptococcal adherence through protein F to the extracellular matrix. EMBO J 1996;15(5):989-998.

(43) Hanski E, Jaffe J, Ozeri V. Proteins F1 and F2 of Streptococcus pyogenes. Properties of fibronectin binding. ADV EXP MED BIOL 1996;408:141-150.

(44) Jaffe J, Natanson-Yaron S, Caparon MG, Hanski E. Protein F2, a novel fibronectin-binding protein from Streptococcus pyogenes, possesses two binding domains. Mol Microbiol 1996;21(2):373-384.

(45) Gibson C, Fogg G, Okada N, Geist RT, Hanski E, Caparon M. Regulation of host cell recognition in Streptococcus pyogenes. Dev Biol Stand 1995;85:137-144.

(46) Hanski E, Fogg G, Tovi A, Okada N, Burstein I, Caparon M. Molecular analysis of Streptococcus pyogenes adhesion. Methods Enzymol 1995;253(C):269-305.

(47) Natanson S, Sela S, Moses AE, Musser JM, Caparon MG, Hanski E. Distribution of fibronectin-binding proteins among group a streptococci of different m types. J Infect Dis 1995;171(4):871-878.

(48) Hanski E. Mechanism of penetration of bordetella pertussis adenylate cyclase toxin into target cells. Toxin Rev 1994;13(1):111-113.

(49) Olsén AN, Hanski E, Normakr S, Caparon MG. Molecular characterization of fibronectin binding proteins in bacteria. J Microbiol Methods 1993;18(3):213-226.

(50) VanHeyningen T, Fogg G, Yates D, Hanski E, Caparon M. Adherence and fibronectin binding are environmentally regulated in the group A streptococci. Mol Microbiol 1993;9(6):1213-1222.

(51) Sela S, Aviv A, Tovi A, Burstein I, Caparon MG, Hanski E. Protein F: an adhesin of Streptococcus pyogenes binds fibronectin via two distinct domains. Mol Microbiol 1993;10(5):1049-1055.

(52) Hanski E, Horwitz PA, Caparon MG. Expression of protein F, the fibronectin-binding protein of Streptococcus pyogenes JRS4, in heterologous streptococcal and enterococcal strains promotes their adherence to respiratory epithelial cells. Infect Immun 1992;60(12):5119-5125.

(53) Hanski E, Caparon M. Protein F, a fibronectin-binding protein, is an adhesin of the group A streptococcus Streptococcus pyogenes. Proc Natl Acad Sci U S A 1992;89(13):6172-6176.

(54) Rogel A, Hanski E. Distinct steps in the penetration of adenylate cyclase toxin of Bordetella pertussis into sheep erythrocytes. Translocation of the toxin across the membrane. J Biol Chem 1992;267(31):22599-22605.

(55) Rogel A, Meller R, Hanski E. Adenylate cyclase toxin from Bordetella pertussis: The relationship between induction of cAMP and hemolysis. J Biol Chem 1991;266(5):3154-3161.

(56) Mouallem M, Farfel Z, Hanski E. Bordetella pertussis adenylate cyclase toxin: Intoxication of host cells by bacterial invasion. Infect Immun 1990;58(11):3759-3764.

(57) Farfel Z, Konen S, Wiertz E, Klapmuts R, Addy PA-, Hanski E. Antibodies to Bordetella pertussis adenylate cyclase are produced in man during pertussis infection and after vaccination. J Med Microbiol 1990;32(3):173-177.

(58) Hanski E. Invasive adenylate cyclase toxin of Bordetella pertussis. Trends Biochem Sci 1989;14(11):459-463.

(59) Gilboa-Ron A, Rogel A, Hanski E. Bordetella pertussis adenylate cyclase inactivation by the host cell. Biochem J 1989;262(1):25-31.

(60) Rogel A, Schultz JE, Brownlie RM, Coote JG, Parton R, Hanski E. Bordetella pertussis adenylate cyclase: purification and characterization of the toxic form of the enzyme. EMBO J 1989;8(9):2755-2760.

(61) Rogel A, Farfel Z, Goldschmidt S, Shiloach J, Hanski E. Bordetella pertussis adenylate cyclase. Identification of multiple forms of the enzyme by antibodies. J Biol Chem 1988;263(26):13310-13316.

(62) Brownlie RM, Coote JG, Parton R, Schultz JE, Rogel A, Hanski E. Cloning of the adenylate cyclase genetic determinant of Bordetella pertussis and its expression in Escherichia coli and B. pertussis. Microb Pathog 1988;4(5):335-344.

(63) Aberdam E, Hanski E, Dekel N. Maintenance of meiotic arrest in isolated rat oocytes by the invasive adenylate cyclase of Bordetella pertussis. Biol Reprod 1987;36(3):530-535.

(64) Friedman E, Farfel Z, Hanski E. The invasive adenylate cyclase of Bordetella pertussis. Properties and penetration kinetics. Biochem J 1987;243(1):145-151.

(65) Farfel Z, Friedman E, Hanski E. The invasive adenylate cyclase of Bordetella pertussis. Intracellular localization and kinetics of penetration into various cells. Biochem J 1987;243(1):153-158.

(66) Heyworth CM, Grey A-, Wilson SR, Hanski E, Houslay MD. The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes. Biochem J 1986;235(1):145-149.

(67) Hanski E, Farfel Z. Bordetella pertussis invasive adenylate cyclase. Partial resolution and properties of its cellular penetration. J Biol Chem 1985;260(9):5526-5532.

(68) Goldman S, Hanski E, Fish F. Studies on phase variation in Bordetella pertussis. Dev Biol Stand 1985;61:255-264.

(69) Pace U, Hanski E, Salomon Y, Lancet D. Odorant-sensitive adenylate cyclase may mediate olfactory reception. Nature 1985;316(6025):255-258.

(70) Farfel Z, Hanski E. Bacterial toxins that affect host cAMP metabolism. Harefuah 1985;108(10):499-501.

(71) Goldman S, Hanski E, Fish F. Spontaneous phase variation in Bordetella pertussis is a multistep non-random process. EMBO J 1984;3(6):1353-1356.

(72) Heyworth CM, Hanski E, Houslay MD. Islet-activating protein blocks glucagon desensitization in intact hepatocytes. Biochem J 1984;222(1):189-194.

(73) Hanski E, Garty NB. Activation of adenylate cyclase by sperm membranes. The role of guanine nucleotide binding proteins. FEBS Lett 1983;162(2):447-452.

(74) Hanski E, Gilman AG. The guanine nucleotide-binding regulatory component of adenylate cyclase in human erythrocytes. J Cyclic Nucleotide Res 1982;8(5):323-336.

(75) Schleifer LS, Kahn RA, Hanski E, Northup JK, Sternweis PC, Gilman AG. Requirements for cholera toxin-dependent ADP-ribosylation of the purified regulatory component of adenylate cyclase. J Biol Chem 1982;257(1):20-23.

(76) Hanski E, Sternweis PC, Northup JK, Dromerick AW, Gilman AG. The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte protein. J Biol Chem 1981;256(24):12911-12919.

(77) Sternweis PC, Northup JK, Hanski E, Schleifer LS, Smigel MD, Gilman AG. Purification and properties of the regulatory component (G/F) of adenylate cyclase. Adv Cyclic Nucleotide Res 1981;14:23-36.

(78) Rimon G, Hanski E, Levitzki A. Temperature Dependence of β Receptor, Adenosine Receptor, and Sodium Fluoride Stimulated Adenylate Cyclase from Turkey Erythrocytes. Biochemistry 1980;19(19):4451-4460.

(79) Atlas D, Hanski E, Levitzki A. Re-evaluation of the number of specific β-Adrenergic receptors on muscle cells (reply) [14]. Nature 1979;277(5691):59-60.

(80) Hanski E, Rimon G, Levitzki A. Adenylate Cyclase Activation by the β-Adrenergic Receptors as a Diffusion-Controlled Process. Biochemistry 1979;18(5):846-853.

(81) Rimon G, Hanski E, Braun S, Levitzki A. Mode of coupling between hormone receptors and adenylate cyclase elucidated by modulation of membrane fluidity [14]. Nature 1978;276(5686):394-396.

(82) Hanski E, Levitzki A. The absence of desensitization in the beta adrenergic receptors of turkey reticulocytes and erythrocytes and its possible origin. Life Sci 1978;22(1):53-60.

(83) Atlas D, Hanski E, Levitzki A. Eighty thousand β-adrenoreceptors in a single cell. Nature 1977;268(5616):144-146.

(84) HANSKI E, SEVILLA N, LEVITZKI A. The Allosteric Inhibition by Calcium of Soluble and Partially Purified Adenylate Cyclase from Turkey Erythrocytes. Eur J Biochem 1977;76(2):513-520.