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The Faculty of Medicine - Microbiology and Molecular Genetics: Jaffe Charles


 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Ashwin H, Sadlova J, Vojtkova B, Becvar T, Lypaczewski P, Schwartz E, et al. Characterization of a new Leishmania major strain for use in a controlled human infection model. Nat Commun 2021;12(1).

(2) Franssen SU, Durrant C, Stark O, Moser B, Downing T, Imamura H, et al. Global genome diversity of the leishmania donovani complex. eLife 2020;9.

(3) Solomon M, Sahar N, Pavlotzky F, Barzilai A, Jaffe CL, Nasereddin A, et al. Mucosal leishmaniasis in travelers with leishmania braziliensis complex returning to israel. Emerg Infect Dis 2019;25(4):642-648.

(4) Abu Ammar A, Nasereddin A, Ereqat S, Dan-Goor M, Jaffe CL, Zussman E, et al. Amphotericin B-loaded nanoparticles for local treatment of cutaneous leishmaniasis. Drug Deliv Transl Res 2019;9(1):76-84.

(5) Yasur-Landau D, Jaffe CL, David L, Doron-Faigenboim A, Baneth G. Resistance of Leishmania infantum to allopurinol is associated with chromosome and gene copy number variations including decrease in the S-adenosylmethionine synthetase (METK) gene copy number. Int J Parasitol Drugs Drug Resist 2018;8(3):403-410.

(6) Jaber HT, Hailu A, Pratlong F, Lami P, Bastien P, Jaffe CL. Analysis of genetic polymorphisms and tropism in East African Leishmania donovani by Amplified Fragment Length Polymorphism and kDNA minicircle sequencing. Infec Genet Evol 2018;65:80-90.

(7) Hicks KA, Mahaffey KW, Mehran R, Nissen SE, Wiviott SD, Dunn B, et al. 2017 Cardiovascular and Stroke Endpoint Definitions for Clinical Trials. J Am Coll Cardiol 2018;71(9):1021-1034.

(8) Zackay A, Cotton JA, Sanders M, Hailu A, Nasereddin A, Warburg A, et al. Genome wide comparison of Ethiopian Leishmania donovani strains reveals differences potentially related to parasite survival. PLoS Genet 2018;14(1).

(9) Rohousova I, Talmi-Frank D, Vlkova M, Spitzova T, Rishpon K, Jaffe CL, et al. Serological evaluation of cutaneous leishmania tropica infection in Northern Israel. Am J Trop Med Hyg 2018;98(1):139-141.

(10) Shalev-Benami M, Zhang Y, Rozenberg H, Nobe Y, Taoka M, Matzov D, et al. Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin. Nat Commun 2017;8(1).

(11) Yasur-Landau D, Jaffe CL, Doron-Faigenboim A, David L, Baneth G. Induction of allopurinol resistance in Leishmania infantum isolated from dogs. PLoS Negl Trop Dis 2017;11(9).

(12) Kirstein OD, Abbasi I, Horwitz BZ, Skrip L, Hailu A, Jaffe C, et al. Minimally invasive microbiopsies: a novel sampling method for identifying asymptomatic, potentially infectious carriers of Leishmania donovani. Int J Parasitol 2017;47(10-11):609-616.

(13) Karakuş M, Nasereddin A, Onay H, Karaca E, Özkeklikçi A, Jaffe CL, et al. Epidemiological analysis of Leishmania tropica strains and giemsa-stained smears from Syrian and Turkish leishmaniasis patients using multilocus microsatellite typing (MLMT). PLoS Negl Trop Dis 2017;11(4).

(14) Van der Auwera G, Bart A, Chicharro C, Cortes S, Davidsson L, Di Muccio T, et al. Comparison of Leishmania typing results obtained from 16 European clinical laboratories in 2014. Eurosurveillance 2016;21(49).

(15) Shalev-Benami M, Zhang Y, Matzov D, Halfon Y, Zackay A, Rozenberg H, et al. 2.8-Å Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania. Cell Rep 2016;16(2):288-294.

(16) Vahermo M, Krogerus S, Nasereddin A, Kaiser M, Brun R, Jaffe CL, et al. Antiprotozoal activity of dehydroabietic acid derivatives against Leishmania donovani and Trypanosoma cruzi. MedChemComm 2016;7(3):457-463.

(17) Pirttimaa M, Nasereddin A, Kopelyanskiy D, Kaiser M, Yli-Kauhaluoma J, Oksman-Caldentey K-, et al. Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi. J Nat Prod 2016;79(2):362-368.

(18) Yasur-Landau D, Jaffe CL, David L, Baneth G. Allopurinol Resistance in Leishmania infantum from Dogs with Disease Relapse. PLoS Negl Trop Dis 2016;10(1).

(19) Shalev M, Rozenberg H, Smolkin B, Nasereddin A, Kopelyanskiy D, Belakhov V, et al. Structural basis for selective targeting of leishmanial ribosomes: Aminoglycoside derivatives as promising therapeutics. Nucleic Acids Res 2015;43(17):8601-8613.

(20) Keurulainen L, Heiskari M, Nenonen S, Nasereddin A, Kopelyanskiy D, Leino TO, et al. Synthesis of carboxyimidamide-substituted benzo[c][1,2,5]oxadiazoles and their analogs, and evaluation of biological activity against Leishmania donovani. MedChemComm 2015;6(9):1673-1678.

(21) Rohousova I, Talmi-Frank D, Kostalova T, Polanska N, Lestinova T, Kassahun A, et al. Exposure to Leishmania spp. and sand flies in domestic animals in northwestern Ethiopia. Parasites Vectors 2015;8(1).

(22) Talmi-Frank D, Jaffe CL, Baneth G. Quantitative computerized western blotting in detail. Western Blotting: Methods and Protocols; 2015. p. 141-150.

(23) Řezníčková E, Popa A, Gucký T, Zatloukal M, Havlíček L, Bazgier V, et al. 2,6,9-trisubstituted purines as CRK3 kinase inhibitors with antileishmanial activity in vitro. Bioorg Med Chem Lett 2015;25(11):2298-2301.

(24) Keurulainen L, Siiskonen A, Nasereddin A, Kopelyanskiy D, Sacerdoti-Sierra N, Leino TO, et al. Synthesis and biological evaluation of 2-arylbenzimidazoles targeting Leishmania donovani. Bioorg Med Chem Lett 2015;25(9):1933-1937.

(25) Talmi-Frank D, Jaffe CL, Baneth G. Quantitative computerized western blotting in detail. Methods Mol Biol 2015;1312:141-150.

(26) Enk CD, Nasereddin A, Alper R, Dan-Goor M, Jaffe CL, Wulf HC. Cutaneous leishmaniasis responds to daylight-activated photodynamic therapy: Proof of concept for a novel self-administered therapeutic modality. Br J Dermatol 2015;172(5):1364-1370.

(27) Das S, Freier A, Boussoffara T, Das S, Oswald D, Losch FO, et al. Modular multiantigen T cell epitope-enriched DNA vaccine against human leishmaniasis. Sci Transl Med 2014;6(234).

(28) Monroy-Ostria A, Nasereddin A, Monteon VM, Guzmán-Bracho C, Jaffe CL. ITS1 PCR-RFLP diagnosis and characterization of leishmania in clinical samples and strains from cases of human cutaneous leishmaniasis in states of the Mexican Southeast. Interdiscip Perspect Infect Dis 2014;2014.

(29) Montalvo AM, Fraga J, El Safi S, Gramiccia M, Jaffe CL, Dujardin J-, et al. Direct Leishmania species typing in Old World clinical samples: Evaluation of 3 sensitive methods based on the heat-shock protein 70 gene. Diagn Microbiol Infect Dis 2014;80(1):35-39.

(30) Haavikko R, Nasereddin A, Sacerdoti-Sierra N, Kopelyanskiy D, Alakurtti S, Tikka M, et al. Heterocycle-fused lupane triterpenoids inhibit Leishmania donovani amastigotes. MedChemComm 2014;5(4):445-451.

(31) Dan-Goor M, Nasereddin A, Jaber H, Jaffe CL. Identification of a secreted casein kinase 1 in Leishmania donovani: Effect of protein over expression on parasite growth and virulence. PLoS ONE 2013;8(11).

(32) Shalev M, Kondo J, Kopelyanskiy D, Jaffe CL, Adir N, Baasov T. Identification of the molecular attributes required for aminoglycoside activity against Leishmania. Proc Natl Acad Sci U S A 2013;110(33):13333-13338.

(33) Ryczak J, Papini M, Lader A, Nasereddin A, Kopelyanskiy D, Preu L, et al. 2-Arylpaullones are selective antitrypanosomal agents. Eur J Med Chem 2013;64:396-400.

(34) Abbasi I, Aramin S, Hailu A, Shiferaw W, Kassahun A, Belay S, et al. Evaluation of PCR procedures for detecting and quantifying Leishmania donovani DNA in large numbers of dried human blood samples from a visceral leishmaniasis focus in Northern Ethiopia. BMC Infect Dis 2013;13(1).

(35) Yisaschar-Mekuzas Y, Jaffe CL, Pastor J, Cardoso L, Baneth G. Identification of Babesia species infecting dogs using reverse line blot hybridization for six canine piroplasms, and evaluation of co-infection by other vector-borne pathogens. Vet Parasitol 2013;191(3-4):367-373.

(36) Faiman R, Abbasi I, Jaffe C, Motro Y, Nasereddin A, Schnur LF, et al. A Newly Emerged Cutaneous Leishmaniasis Focus in Northern Israel and Two New Reservoir Hosts of Leishmania major. PLoS Negl Trop Dis 2013;7(2).

(37) Zackay A, Nasereddin A, Takele Y, Tadesse D, Hailu W, Hurissa Z, et al. Polymorphism in the HASPB Repeat Region of East African Leishmania donovani Strains. PLoS Negl Trop Dis 2013;7(1).

(38) Talmi-Frank D, Jaffe CL, Nasereddin A, Baneth G. Leishmania tropica experimental infection in the rat using luciferase-transfected parasites. Vet Parasitol 2012;187(1-2):57-62.

(39) Jorda R, Sacerdoti-Sierra N, Voller J, Havlíček L, Kráčalíková K, Nowicki MW, et al. Anti-leishmanial activity of disubstituted purines and related pyrazolo[4,3-d]pyrimidines. Bioorg Med Chem Lett 2011;21(14):4233-4237.

(40) Kovalenko DA, Razakov SA, Ponirovsky EN, Warburg A, Nasyrova RM, Ponomareva VI, et al. Canine leishmaniosis and its relationship to human visceral leishmaniasis in Eastern Uzbekistan. Parasites Vectors 2011;4(1).

(41) Talmi-Frank D, Kedem-Vaanunu N, King R, Bar-Gal GK, Edery N, Jaffe CL, et al. Leishmania tropica infection in golden jackals and red foxes, Israel. Emerg Infect Dis 2010;16(12):1973-1975.

(42) Nasereddin A, Jaffe CL. Rapid diagnosis of old world leishmaniasis by high-resolution melting analysis of the 7sl RNA gene. J Clin Microbiol 2010;48(6):2240-2242.

(43) Talmi-Frank D, Jaffe CL, Nasereddin A, Warburg A, King R, Svobodova M, et al. Leishmania tropica in rock hyraxes (Procavia capensis) in a focus of human cutaneous leishmaniasis. Am J Trop Med Hyg 2010;82(5):814-818.

(44) Alakurtti S, Bergström P, Sacerdoti-Sierra N, Jaffe CL, Yli-Kauhaluoma J. Anti-leishmanial activity of betulin derivatives. J Antibiot 2010;63(3):123-126.

(45) Alakurtti S, Heiska T, Kiriazis A, Sacerdoti-Sierra N, Jaffe CL, Yli-Kauhaluoma J. Synthesis and anti-leishmanial activity of heterocyclic betulin derivatives. Bioorg Med Chem 2010;18(4):1573-1582.

(46) Nasereddin A, Schweynoch C, Schonian G, Jaffe CL. Characterization of Leishmania (Leishmania) tropica axenic amastigotes. Acta Trop 2010;113(1):72-79.

(47) Talmi-Frank D, Nasereddin A, Schnur LF, Schönian G, Töz SÖ, Jaffe CL, et al. Detection and identification of old world leishmania by high resolution melt analysis. PLoS Negl Trop Dis 2010;4(1).

(48) Toz SO, Nasereddin A, Ozbel Y, Ertabaklar H, Culha G, Sevil N, et al. Leishmaniasis in Turkey: Molecular characterization of Leishmania from human and canine clinical samples. Trop Med Int Health 2009;14(11):1401-1406.

(49) Malki-Feldman L, Jaffe CL. Leishmania major: Effect of protein kinase A and phosphodiesterase activity on infectivity and proliferation of promastigotes. Exp Parasitol 2009;123(1):39-44.

(50) Nasereddin A, Azmi K, Jaffe CL, Ereqat S, Amro A, Sawalhah S, et al. Kinetoplast DNA heterogeneity among Leishmania infantum strains in central Israel and Palestine. Vet Parasitol 2009;161(1-2):126-130.

(51) Amro A, Schönian G, Al-Sharabati MB, Azmi K, Nasereddin A, Abdeen Z, et al. Population genetics of Leishmania infantum in Israel and the Palestinian Authority through microsatellite analysis. Microbes Infect 2009;11(4):484-492.

(52) Talmi-Frank D, Jaffe CL, Baneth G. Quantitative computerized western blotting. Methods Mol Biol 2009;536:103-113.

(53) Shimony O, Jaffe CL. Rapid fluorescent assay for screening drugs on Leishmania amastigotes. J Microbiol Methods 2008;75(2):196-200.

(54) Gradoni L, Soteriadou K, Louzir H, Dakkak A, Toz SO, Jaffe C, et al. Drug regimens for visceral leishmaniasis in Mediterranean countries. Trop Med Int Health 2008;13(10):1272-1276.

(55) Nasereddin A, Bensoussan-Hermano E, Schönian G, Baneth G, Jaffe CL. Molecular diagnosis of old world cutaneous leishmaniasis and species identification by use of a reverse line blot hybridization assay. J Clin Microbiol 2008;46(9):2848-2855.

(56) Reichwald C, Shimony O, Sacerdoti-Sierra N, Jaffe CL, Kunick C. A new Heck reaction modification using ketone Mannich bases as enone precursors: Parallel synthesis of anti-leishmanial chalcones. Bioorg Med Chem Lett 2008;18(6):1985-1989.

(57) Reichwald C, Shimony O, Dunkel U, Sacerdoti-Sierra N, Jaffe CL, Kunick C. 2-(3-Aryl-3-oxopropen-1-yl)-9-tert-butyl-paullones: A new antileishmanial chemotype. J Med Chem 2008;51(3):659-665.

(58) Anti-leishmanial activity of betulin derivatives. 2008 Nordic Wood Biorefinery Conference, NWBC 2008 - Proceedings; 2008.

(59) Strauss-Ayali D, Baneth G, Jaffe CL. Splenic immune responses during canine visceral leishmaniasis. Vet Res 2007;38(4):547-564.

(60) Bensoussan E, Nasereddin A, Jonas F, Schnur LF, Jaffe CL. Comparison of PCR assays for diagnosis of cutaneous leishmaniasis. J Clin Microbiol 2006;44(4):1435-1439.

(61) Talmi-Frank D, Strauss-Ayali D, Jaffe CL, Baneth G. Kinetics and diagnostic and prognostic potential of quantitative Western blot analysis and antigen-specific enzyme-linked immunosorbent assay in experimental canine leishmaniasis. Clin Vaccine Immunol 2006;13(2):271-276.

(62) Nasereddin A, Ereqat S, Azmi K, Baneth G, Jaffe CL, Abdeen Z. Serological survey with PCR validation for canine visceral leishmaniasis in northern Palestine. J Parasitol 2006;92(1):178-183.

(63) Schwenkenbecher JM, Wirth T, Schnur LF, Jaffe CL, Schallig H, Al-Jawabreh A, et al. Microsatellite analysis reveals genetic structure of Leishmania tropica. Int J Parasitol 2006;36(2):237-246.

(64) Nasereddin A, Baneth G, Schönian G, Kanaan M, Jaffe CL. Molecular fingerprinting of Leishmania infantum strains following an outbreak of visceral leishmaniasis in central Israel. J Clin Microbiol 2005;43(12):6054-6059.

(65) Ehrenfreund-Kleinman T, Domb AJ, Jaffe CL, Nasereddin A, Leshem B, Golenser J. The effect of amphotericin B derivatives on Leishmania and immune functions. J Parasitol 2005;91(1):158-163.

(66) Strauss-Ayali D, Baneth G, Shor S, Okano F, Jaffe CL. Interleukin-12 augments a Th1-type immune response manifested as lymphocyte proliferation and interferon gamma production in Leishmania infantum-infected dogs. Int J Parasitol 2005;35(1):63-73.

(67) Shani-Adir A, Kamil S, Rozenman D, Schwartz E, Ramon M, Zalman L, et al. Leishmania tropica in northern Israel: A clinical overview of an emerging focus. J Am Acad Dermatol 2005;53(5):810-815.

(68) Nasereddin A, Jaffe CL. Effect of the security fence on zoonotic visceral leishmaniasis in Israel and Palestine. Lancet Infect Dis 2004;4(7):393-394.

(69) Jaffe CL, Baneth G, Abdeen ZA, Schlein Y, Warburg A. Leishmaniasis in Israel and the Palestinian Authority. Trends Parasitol 2004;20(7):328-332.

(70) Strauss-Ayali D, Jaffe CL, Burshtain O, Gonen L, Baneth G. Polymerase chain reaction using noninvasively obtained samples, for the detection of Leishmania infantum DNA in dogs. J Infect Dis 2004;189(9):1729-1733.

(71) Ya'ari A, Jaffe CL, Garty B-. Visceral leishmaniasis in Israel, 1960-2000. Isr Med Assoc J 2004;6(4):205-208.

(72) Schnur LF, Nasereddin A, Eisenberger CL, Jaffe CL, El Fari M, Azmi K, et al. Multifarious characterization of Leishmania tropica from a Judean desert focus, exposing intraspecific diversity and incriminating Phlebotomus sergenti as its vector. Am J Trop Med Hyg 2004;70(4):364-372.

(73) Jaffe CL, Dwyer DM. Extracellular release of the surface metalloprotease, gp63, from Leishmania and insect trypanosomatids. Parasitol Res 2003;91(3):229-237.

(74) Jacobson RL, Eisenberger CL, Svobodova M, Baneth G, Sztern J, Carvalho J, et al. Outbreak of Cutaneous Leishmaniasis in Northern Israel. J Infect Dis 2003;188(7):1065-1073.

(75) Schönian G, Nasereddin A, Dinse N, Schweynoch C, Schallig HDFH, Presber W, et al. PCR diagnosis and characterization of Leishmania in local and imported clinical samples. Diagn Microbiol Infect Dis 2003;47(1):349-358.

(76) Marfurt J, Nasereddin A, Niederwieser I, Jaffe CL, Beck H-, Felger I. Identification and differentiation of Leishmania species in clinical samples by PCR amplification of the miniexon sequence and subsequent restriction fragment length polymorphism analysis. J Clin Microbiol 2003;41(7):3147-3153.

(77) Enk CD, Fritsch C, Jonas F, Nasereddin A, Ingber A, Jaffe CL, et al. Treatment of cutaneous Leishmaniasis with photodynamic therapy. Arch Dermatol 2003;139(4):432-434.

(78) Adini I, Ephros M, Chen J, Jaffe CL. Asymptomatic visceral leishmaniasis, Northern Israel. Emerg Infect Dis 2003;9(3):397-398.

(79) Bulle B, Millon L, Bart J-, Gállego M, Gambarelli F, Portús M, et al. Practical approach for typing strains of Leishmania infantum by microsatellite analysis. J Clin Microbiol 2002;40(9):3391-3397.

(80) Siman-Tov MM, Ivens AC, Jaffe CL. Molecular cloning and characterization of two new isoforms of the protein kinase A catalytic subunit from the human parasite Leishmania. Gene 2002;288(1-2):65-75.

(81) Vieira LL, Sacerdoti-Sierra N, Jaffe CL. Effect of pH and temperature on protein kinase release by Leishmania donovani. Int J Parasitol 2002;32(9):1085-1093.

(82) Ben-Ami R, Schnur LF, Golan Y, Jaffe CL, Mardi T, Zeltser D. Cutaneous involvement in a rare case of adult visceral leishmaniasis acquired in Israel. J Infect 2002;44(3):181-184.

(83) Abdeen ZA, Sawalha SS, Eisenberger CL, Khanfar HM, Greenblatt CL, Yousef O, et al. Epidemiology of visceral leishmaniasis in the Jenin district, West Bank: 1989-1998. Am J Trop Med Hyg 2002;66(4):329-333.

(84) Siman-Tov MM, Ivens AC, Jaffe CL. Identification and cloning of Lmairk, a member of the Aurora/Ipl1p protein kinase family, from the human protozoan parasite Leishmania. Biochim Biophys Acta Gene Struct Expr 2001;1519(3):241-245.

(85) Marom D, Offer I, Tamary H, Jaffe CL, Garty BZ. Hemophagocytic lymphohistiocytosis associated with visceral leishmaniasis. Pediatr Hematol Oncol 2001;18(1):65-70.

(86) Duncan R, Alvarez R, Jaffe CL, Wiese M, Klutch M, Shakarian A, et al. Early response gene expression during differentiation of cultured Leishmania donovani. Parasitol Res 2001;87(11):897-906.

(87) Ozbel Y, Oskam L, Ozensoy S, Turgay N, Alkan MZ, Jaffe CL, et al. A survey on canine leishmaniasis in western Turkey by parasite, DNA and antibody detection assays. Acta Trop 2000;74(1):1-6.

(88) Baneth G, Shkap V, Samish M, Jaffe CL. Antigenic analysis of gamonts of Hepatozoon canis purified from leukocytes. J Parasitol 2000;86(2):289-294.

(89) Rhalem A, Sahibi H, Lasri S, Jaffe CL. Analysis of immune responses in dogs with canine visceral leishmaniasis before, and after, drug treatment. Vet Immunol Immunopathol 1999;71(1):69-76.

(90) Chatterjee M, Baneth G, Jaffe CL, Sharma V, Mandal C. Diagnostic and prognostic potential of antibodies against O-acetylated sialic acids in canine visceral leishmaniasis. Vet Immunol Immunopathol 1999;70(1-2):55-65.

(91) Jaffe CL. Recent trends in vaccine development and immunization. Clin Dermatol 1999;17(3):339-344.

(92) Eisenberger CL, Jaffe CL. Leishmania: Identification of old world species using a permissively primed intergenic polymorphic-polymerase chain reaction. Exp Parasitol 1999;91(1):70-77.

(93) Eisenberger CL, Jaffe CL. Erratum: Leishmania: Identification of old world species using a permissively primed intergenic polymorphic-polymerase chain reaction (Experimental Parasitology (1999) 91:1 (70-77)). Exp Parasitol 1999;92(2):159-160.

(94) Lasri S, Sahibi H, Sadak A, Jaffe CL, Rhalem A. Immune responses in vaccinated dogs with autoclaved Leishmania major promastigotes. Vet Res 1999;30(5-6):441-449.

(95) Chatterjee M, Jaffe CL, Sundar S, Basu D, Sen S, Mandal C. Diagnostic and prognostic potential of a competitive enzyme-linked immunosorbent assay for leishmaniasis in India. Clin Diagn Lab Immunol 1999;6(4):550-554.

(96) Adini I, Jacobson RL, Kasap M, Schlein Y, Jaffe CL. Species-specific detection of Leishmania in sandflies using an enzyme-linked immunosorbent assay. Trans R Soc Trop Med Hyg 1998;92(1):35-37.

(97) Lira R, Méndez S, Carrera L, Jaffe C, Neva F, Sacks D. Leishmania tropica: The identification and purification of metacyclic promastigotes and use in establishing mouse and hamster models of cutaneous and visceral disease. Exp Parasitol 1998;89(3):331-342.

(98) Baneth G, Dank G, Keren-Kornblatt E, Sekeles E, Adini I, Eisenberger CL, et al. Emergence of visceral leishmaniasis in central Israel. Am J Trop Med Hyg 1998;59(5):722-725.

(99) Sacerdoti-Sierra N, Jaffe CL. Release of ecto-protein kinases by the protozoan parasite Leishmania major. J Biol Chem 1997;272(49):30760-30765.

(100) Becker S, Jaffe CL. Effect of protein kinase inhibitors on the growth, morphology, and infectivity of Leishmania promastigotes. Parasitol Res 1997;83(3):273-280.

(101) Baneth G, Jaffe CL, Zur G, Schnur LF. Visceral leishmaniasis--an emerging zoonosis in the Jerusalem area. Isr J Med Sci 1996;32(5):337.

(102) Siman-Tov MM, Radi A, Shapira M, Jaffe CL. Cloning from Leishmania major of a developmentally regulated gene, c-lpk2, for the catalytic subunit of the cAMP-dependent protein kinase. Mol Biochem Parasitol 1996;77(2):201-215.

(103) Sacks DL, Kenney RT, Neva FA, Kreutzer RD, Jaffe CL, Gupta AK, et al. Indian kala-azar caused by Leishmania tropica. Lancet 1995;345(8955):959-961.

(104) Hommel M, Jaffe CL, Travi B, Milon G. Experimental models for leishmaniasis and for testing anti-leishmanial vaccines. Ann Trop Med Parasitol 1995;89(SUPPL. 1):55-73.

(105) McConville MJ, Schnur LF, Jaffe C, Schneider P. Structure of Leishmania lipophosphoglycan: Inter- and intra-specific polymorphism in Old World species. Biochem J 1995;310(3):807-818.

(106) Ozbel Y, Turgay N, Ozensoy S, Ozbilgin A, Alkan MZ, Ozcel MA, et al. Epidemiology, diagnosis and control of leishmaniasis in the Mediterranean region. Ann Trop Med Parasitol 1995;89(SUPPL. 1):89-93.

(107) Passwell JH, Shor R, Smolen J, Jaffe CL. Infection of human monocytes by Leishmania results in a defective oxidative burst. Int J Exp Pathol 1994;75(4):277-284.

(108) Schneider P, Schnur LF, Jaffe CL, Ferguson MAJ, McConville MJ. Glycoinositol-phospholipid profiles of four serotypically distinct old world Leishmania strains. Biochem J 1994;304(2):603-609.

(109) Hermoso T, Jaffe CL. Phosphorylation of proteins in virulent promastigotes from Leishmania major. Biol Res 1993;26(1-2):267-271.

(110) Rachamim N, Jaffe CL. Pure protein from Leishmania donovani protects mice against both cutaneous and visceral leishmaniasis. J Immunol 1993;150(6):2322-2331.

(111) LYTTON SD, MOZES E, JAFFE CL. Effect of macrophage infection by Leishmania on the proliferation of an antigen‐specific T‐cell line, TPB1, to a non‐parasite antigen. Parasite Immunol 1993;15(8):489-492.

(112) Padeh S, Jaffe CL, Passwell JH. Activation of human monocytes via their sIgA receptors. Immunology 1991;72(2):188-193.

(113) GOLDMAN R, JAFFE CL. Administration of β‐glucan following Leishmania major infection suppresses disease progression in mice. Parasite Immunol 1991;13(2):137-145.

(114) Lester DS, Hermoso T, Jaffe CL. Extracellular dephosphorylation in the parasite, Leishmania major. Acta Cient Venez 1991;42(6):326-329.

(115) Zilberstein D, Blumenfeld N, Liveanu V, Gepstein A, Jaffe CL. Growth at acidic pH induces an amastigote stage-specific protein in Leishmania promastigotes. Mol Biochem Parasitol 1991;45(1):175-178.

(116) Hermoso T, Fishelson Z, Becker SI, Hirschberg K, Jaffe CL. Leishmanial protein kinases phosphorylate components of the complement system. EMBO J 1991;10(13):4061-4067.

(117) Rachamim N, Jaffe CL, Abranches P, Silva-Pereira MCD, Schnur LF, Jacobson RL. Serodiagnosis of canine visceral leishmaniasis in Portugal: Comparison of three methods. Ann Trop Med Parasitol 1991;85(5):503-508.

(118) ABRANCHES P, SANTOS‐GOMES G, RACHAMIM N, CAMPINO L, SCHNUR LF, JAFFE CL. An experimental model for canine visceral leishmaniasis. Parasite Immunol 1991;13(5):537-550.

(119) Lester DS, Hermoso T, Jaffe CL. Extracellular phosphorylation in the parasite, Leishmania major. Biochim Biophys Acta Mol Cell Res 1990;1052(2):293-298.

(120) Jaffe CL, Leonor Perez M, Schnur LF. Lipophosphoglycan and secreted acid phosphatase of Leishmania tropica share species-specific epitopes. Mol Biochem Parasitol 1990;41(2):233-240.

(121) Jaffe CL, Pérez ML, Sarfstein R. Leishmania tropica: Characterization of a lipophosphoglycan-like antigen recognized by species-specific monoclonal antibodies. Exp Parasitol 1990;70(1):12-24.

(122) Schnur LF, Sarfstein R, Jaffe CL. Monoclonal antibodies against leishmanial membranes react with specific excreted factors (EF). Ann Trop Med Parasitol 1990;84(5):447-456.

(123) Jaffe CL, Rachamim N, Sarfstein R. Characterization of two proteins from Leishmania donovani and their use for vaccination against visceral leishmaniasis. J Immunol 1990;144(2):699-706.

(124) Jaffe CL, Shor R, Trau H, Passwell JH. Parasite antigens recognized by patients with cutaneous leishmaniasis. Clin Exp Immunol 1990;80(1):77-82.

(125) Jaffe CL. Leishmaniasis after Adler and beyond. Isr J Med Sci 1989;25(4):181-183.

(126) Jaffe CL, Rachamim N. Amastigote stage-specific monoclonal antibodies against Leishmania major. Infect Immun 1989;57(12):3770-3777.

(127) Argov S, Jaffe CL, Krupp M, Slor H, Shoenfeld Y. Autoantibody production by patients infected with Leishmania. Clin Exp Immunol 1989;76(2):190-197.

(128) Jaffe CL, Keren E, Nahary O, Rachamim N, Schnur L. Canine visceral Leishmaniasis at Wadi Hamam, in Israel. Trans R Soc Trop Med Hyg 1988;82(6):852-853.

(129) Jaffe CL, Zalis M, Jaffe CL. Use of purified parasite proteins from leishmartia donovani for the rapid serodiagnosis of visceral leishmaniasis. J Infect Dis 1988;157(6):1212-1220.

(130) Jaffe CL, McMahon-Pratt D. The identification of membrane glycoconjugates in Leishmania species. J Parasitol 1988;74(4):548-561.

(131) Jaffe CL, Zalis M. Purification of two Leishmania donovani membrane proteins recognized by sera from patients with visceral leishmaniasis. Mol Biochem Parasitol 1988;27(1):53-62.

(132) Shapira M, McEwen JG, Jaffe CL. Temperature effects on molecular processes which lead to stage differentiation in Leishmania. EMBO J 1988;7(9):2895-2901.

(133) Passwell JH, Shor R, Trau H, Shoham J, Jaffe CL. Antigen-stimulated lymphokines from patients with cutaneous leishmaniasis induce monocyte killing of Leishmania major intracellular amastigotes. J Immunol 1987;139(12):4208-4212.

(134) Zalis M, Jaffe CL. Routine dot-blot assay of multiple serum samples using a simple apparatus. J Immunol Methods 1987;101(2):261-264.

(135) Jaffe CL, McMahon-Pratt D. Serodiagnostic assay for visceral leishmaniasis employing monoclonal antibodies. Trans R Soc Trop Med Hyg 1987;81(4):587-594.

(136) Jaffe CL, Sarfstein R. Species-specific antibodies to Leishmania tropica (minor) recognize somatic antigens and exometabolites. J Immunol 1987;139(4):1310-1319.

(137) McMahon Pratt D, Bennett E, Grimaldi G, Jaffe CL. Subspecies- and species-specific antigens of Leishmania mexicana characterized by monoclonal antibodies. J Immunol 1985;134(3):1935-1940.

(138) Momen H, Grimaldi Jr. G, Pacheco RS, Jaffe CL, McMahon-Pratt D, Marzochi MC. Brazilian Leishmania stocks phenotypically similar to Leishmania major. Am J Trop Med Hyg 1985;34(6):1076-1084.

(139) Boyer MH, Jaffe CL. Increased susceptibility to Leishmania tropica infection in autoimmune MRL/MpJ-Ipr mice. J Parasitol 1984;70(1):145-146.

(140) Gardiner PR, Jaffe CL, Dwyer DM. Identification of cross-reactive promastigote cell surface antigens of some leishmanial stocks by 125I labeling and immunoprecipiation. Infect Immun 1984;43(2):637-643.

(141) McMahon Pratt D, Bennett E, Jaffe CL. Stage specific antigens of Leishmania. Fed Proc 1984;43(6).

(142) Jaffe CL, Bennett E, Grimaldi Jr. G, McMahon-Pratt D. Production and characterization of species-specific monoclonal antibodies against Leishmania donovani for immunodiagnosis. J Immunol 1984;133(1):440-447.

(143) Grimaldi G, Jaffe CL, McMahon-Pratt D, Falqueto A. A simple procedure for the isolation of leishmanial parasites and for the recovery of parasite virulence in avirulent stocks. Trans R Soc Trop Med Hyg 1984;78(4):560.

(144) Jaffe CL, McMahon Pratt D. Monoclonal antibodies specific for Leishmania tropica. I. Characterization of antigens associated with stage- and species-specific determinants. J Immunol 1983;131(4):1987-1993.

(145) Lis H, Jaffe CL, Sharon N. Variations in the susceptibility of erythrocyte membrane glycolipids to galactose oxidase. FEBS Lett 1982;147(1):59-63.

(146) Aplin JD, Hughes RC, Jaffe CL, Sharon N. Reversible cross-linking of cellular components of adherent fibroblasts to fibronectin and lectin-coated substrata. Exp Cell Res 1981;134(2):488-494.

(147) Jaffe CL, Lis H, Sharon N. New Cleavable Photoreactive Heterobifunctional Cross-Linking Reagents for Studying Membrane Organization. Biochemistry 1980;19(19):4423-4429.

(148) Jaffe CL, Lis H, Sharon N. Identification of peanut agglutinin receptors on human erythrocyte ghosts by affinity crosslinking using a new cleavable heterobifunctional reagent. Biochem Biophys Res Commun 1979;91(2):402-409.

(149) Jaffe CL, Ehrlich-Rogozinski S, Lis H, Sharon N. Transition metal requirements of soybean agglutinin. FEBS Lett 1977;82(2):191-196.