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The Faculty of Medicine - Microbiology and Molecular Genetics: Jarrous Nayef

Researchers

 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Jarrous N, Rouvinski A. RNA polymerase III and antiviral innate immune response. Transcription 2021.

(2) Jarrous N, Mani D, Ramanathan A. Coordination of transcription and processing of tRNA. FEBS J 2021.

(3) Ramanathan A, Weintraub M, Orlovetskie N, Serruya R, Mani D, Marcu O, et al. A mutation in POLR3E impairs antiviral immune response and RNA polymerase III. Proc Natl Acad Sci U S A 2020;117(36):22113-22121.

(4) Zhou B, Semanjski M, Orlovetskie N, Bhattacharya S, Alon S, Argaman L, et al. Arginine dephosphorylation propels spore germination in bacteria. Proc Natl Acad Sci U S A 2019;116(28):14228-14237.

(5) Gopalan V, Jarrous N, Krasilnikov AS. Chance and necessity in the evolution of RNase P. RNA 2018;24(1):1-5.

(6) Abu-Zhayia ER, Khoury-Haddad H, Guttmann-Raviv N, Serruya R, Jarrous N, Ayoub N. A role of human RNase P subunits, Rpp29 and Rpp21, in homology directed-repair of double-strand breaks. Sci Rep 2017;7(1).

(7) Jarrous N. Roles of RNase P and Its Subunits. Trends Genet 2017;33(9):594-603.

(8) Orlovetskie N, Serruya R, Abboud-Jarrous G, Jarrous N. Targeted inhibition of WRN helicase, replication stress and cancer. Biochim Biophys Acta Rev Cancer 2017;1867(1):42-48.

(9) Hitrik A, Abboud-Jarrous G, Orlovetskie N, Serruya R, Jarrous N. Targeted inhibition of WRN helicase by external guide sequence and RNase P RNA. Biochim Biophys Acta Gene Regul Mech 2016;1859(4):572-580.

(10) Serruya R, Orlovetskie N, Reiner R, Dehtiar-Zilber Y, Wesolowski D, Altman S, et al. Human RNase P ribonucleoprotein is required for formation of initiation complexes of RNA polymerase III. Nucleic Acids Res 2015;43(11):5442-5450.

(11) Reiner R, Alfiya-Mor N, Berrebi-Demma M, Wesolowski D, Altman S, Jarrous N. RNA binding properties of conserved protein subunits of human RNase P. Nucleic Acids Res 2011;39(13):5704-5714.

(12) Jarrous N, Gopalan V. Archaeal/Eukaryal RNase P: Subunits, functions and RNA diversification. Nucleic Acids Res 2010;38(22):7885-7894.

(13) Jarrous N, Reiner R, Dehtiar Y. Human RNase P and transcription. Protein Rev 2010;10:223-234.

(14) Reiner R, Krasnov-Yoeli N, Dehtiar Y, Jarrous N. Function and assembly of a chromatin-associated RNase P that is required for efficient transcription by RNA polymerase I. PLoS ONE 2008;3(12).

(15) Jarrous N, Reiner R. Human RNase P: A tRNA-processing enzyme and transcription factor. Nucleic Acids Res 2007;35(11):3519-3524.

(16) Reiner R, Ben-Asouli Y, Krilovetzky I, Jarrous N. A role for the catalytic ribonucleoprotein RNase P in RNA polymerase III transcription. Genes Dev 2006;20(12):1621-1635.

(17) Sharin E, Schein A, Mann H, Ben-Asouli Y, Jarrous N. RNase P: Role of distinct protein cofactors in tRNA substrate recognition and RNA-based catalysis. Nucleic Acids Res 2005;33(16):5120-5132.

(18) Cohen A, Reiner R, Jarrous N. Alterations in the intracellular level of a protein subunit of human RNase P affect processing of tRNA precursors. Nucleic Acids Res 2003;31(16):4836-4846.

(19) Mann H, Ben-Asouli Y, Schein A, Moussa S, Jarrous N. Eukaryotic RNase P: Role of RNA and protein subunits of a primordial catalytic ribonucleoprotein in RNA-based catalysis. Mol Cell 2003;12(4):925-935.

(20) Jarrous N. Human ribonuclease P: Subunits, function, and intranuclear localization. RNA 2002;8(1):1-7.

(21) Jarrous N, Reiner R, Wesolowski D, Mann H, Guerrier-Takada C, Altman S. Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P. RNA 2001;7(8):1153-1164.

(22) Jarrous N, Altman S. Human ribonuclease P. Methods Enzymol 2001;342:93-100.

(23) Van Eenennaam H, Jarrous N, Van Venrooij WJ, Pruijn GJM. Architecture and function of the human endonucleases RNase P and RNase MRP. IUBMB Life 2000;49(4):265-272.

(24) Osman F, Jarrous N, Ben-Asouli Y, Kaempfer R. A cis-acting element in the 3'-untranslated region of human TNF-α mRNA renders splicing dependent on the activation of protein kinase PKR. Genes Dev 1999;13(24):3280-3293.

(25) Jarrous N, Wolenski JS, Wesolowski D, Lee C, Altman S. Localization in the nucleolus and coiled bodies of protein subunits of the ribonucleoprotein ribonuclease P. J Cell Biol 1999;146(3):559-571.

(26) Jarrous N, Eder PS, Wesolowski D, Altman S. Rpp14 and Rpp29, two protein subunits of human ribonuclease P. RNA 1999;5(2):153-157.

(27) Jarrous N, Eder PS, Guerrier-Takada C, Hoog C, Altman S. Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P. RNA 1998;4(4):407-417.

(28) Jarrous N, Osman F, Kaempfer R. 2-Aminopurine selectively inhibits splicing of tumor necrosis factor alpha mRNA. Mol Cell Biol 1996;16(6):2814-2822.

(29) Jarrous N, Kaempfer R. Induction of human interleukin-1 gene expression by retinoic acid and its regulation at processing of precursor transcripts. J Biol Chem 1994;269(37):23141-23149.