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The Faculty of Medicine - Microbiology and Molecular Genetics: Rosen Haim

Researchers

 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Shahar M, Szalat A, Rosen H. Pathogenic Stress Induces Human Monocyte to Express an Extracellular Web of Tunneling Nanotubes. Front Immunol 2021;12.

(2) Singh SV, Fedorova OV, Wei W, Rosen H, Horesh N, Ilani A, et al. Na+, k+-atpase α isoforms and endogenous cardiac steroids in prefrontal cortex of bipolar patients and controls. Int J Mol Sci 2020;21(16):1-16.

(3) Hodes A, Rosen H, Cohen-Ben Ami H, Lichtstein D. Na+, K+-ATPase α3 isoform in frontal cortex GABAergic neurons in psychiatric diseases. J Psychiatr Res 2019;115:21-28.

(4) Buzaglo N, Golomb M, Rosen H, Beeri R, Ami HC-, Langane F, et al. Augmentation of Ouabain-Induced Increase in Heart Muscle Contractility by Akt Inhibitor MK-2206. J Cardiovasc Pharmacol Ther 2019;24(1):78-89.

(5) Lichtstein D, Ilani A, Rosen H, Horesh N, Singh SV, Buzaglo N, et al. Na+, K+-ATPase signaling and bipolar disorder. Int J Mol Sci 2018;19(8).

(6) Hodes A, Lifschytz T, Rosen H, Cohen Ben-Ami H, Lichtstein D. Reduction in endogenous cardiac steroids protects the brain from oxidative stress in a mouse model of mania induced by amphetamine. Brain Res Bull 2018;137:356-362.

(7) Hodes A, Rosen H, Deutsch J, Lifschytz T, Einat H, Lichtstein D. Endogenous cardiac steroids in animal models of mania. Bipolar Disord 2016;18(5):451-459.

(8) Buzaglo N, Rosen H, Ami HCB, Inbal A, Lichtstein D. Essential opposite roles of ERK and akt signaling in cardiac steroid-induced increase in heart contractility. J Pharmacol Exp Ther 2016;357(2):345-356.

(9) Szalat A, Shahar M, Shpitzen S, Nachmias B, Munter G, Gillis D, et al. Calcium-sensing receptor sequencing in 21 patients with idiopathic or familial parathyroid disorder: pitfalls and characterization of a novel I32 V loss-of-function mutation. Endocrine 2015;48(2):444-453.

(10) Dvela-Levitt M, Cohen-Ben Ami H, Rosen H, Ornoy A, Hochner-Celnikier D, Granat M, et al. Reduction in maternal circulating ouabain impairs offspring growth and kidney development. J Am Soc Nephrol 2015;26(5):1103-1114.

(11) Dvela-Levitt M, Ami HC-, Rosen H, Shohami E, Lichtstein D. Ouabain improves functional recovery following traumatic brain injury. J Neurotrauma 2014;31(23):1942-1947.

(12) Nesher M, Bai Y, Li D, Rosen H, Lichtstein D, Liu L. Interaction of atrial natriuretic peptide and ouabain in the myocardium. Can J Physiol Pharmacol 2012;90(10):1386-1393.

(13) Lichtstein D, Rosen H, Dvela M. Cardenolides and bufadienolides as hormones: What is missing? Am J Physiol Renal Physiol 2012;302(8):F957-F958.

(14) Fridman E, Lichtstein D, Rosen H. Formation of new high density glycogen-microtubule structures is induced by cardiac steroids. J Biol Chem 2012;287(9):6518-6529.

(15) Dvela M, Rosen H, Ben-Ami HC, Lichtstein D. Endogenous ou0061bain regulates cell viability. Am J Physiol Cell Physiol 2012;302(2):C442-C452.

(16) Goldstein I, Lax E, Gispan-Herman I, Ovadia H, Rosen H, Yadid G, et al. Neutralization of endogenous digitalis-like compounds alters catecholamines metabolism in the brain and elicits anti-depressive behavior. Eur Neuropsychopharmacol 2012;22(1):72-79.

(17) Feldmann T, Shahar M, Baba A, Matsuda T, Lichtstein D, Rosen H. The Na+/Ca2+-exchanger: An essential component in the mechanism governing cardiac steroid-induced slow Ca2+ oscillations. Cell Calcium 2011;50(5):424-432.

(18) Nesher M, Shpolansky U, Viola N, Dvela M, Buzaglo N, Ben-Ami HC, et al. Ouabain attenuates cardiotoxicity induced by other cardiac steroids. Br J Pharmacol 2010;160(2):346-354.

(19) Nesher M, Dvela M, Igbokwe VU, Rosen H, Lichtstein D. Physiological roles of endogenous ouabain in normal rats. Am J Physiol Heart Circ Physiol 2009;297(6):H2026-H2034.

(20) Goldstein I, Lerer E, Laiba E, Mallet J, Mujaheed M, Laurent C, et al. Association Between Sodium- and Potassium-Activated Adenosine Triphosphatase α Isoforms and Bipolar Disorders. Biol Psychiatry 2009;65(11):985-991.

(21) Dvela M, Rosen H, Feldmann T, Nesher M, Lichtstein D. Diverse biological responses to different cardiotonic steroids. Pathophysiology 2007;14(3-4):159-166.

(22) Feldmann T, Glukmann V, Medvenev E, Shpolansky U, Galili D, Lichtstein D, et al. Role of endosomal Na+-K+-ATPase and cardiac steroids in the regulation of endocytosis. Am J Physiol Cell Physiol 2007;293(3):C885-C896.

(23) Nesher M, Shpolansky U, Rosen H, Lichtstein D. The digitalis-like steroid hormones: New mechanisms of action and biological significance. Life Sci 2007;80(23):2093-2107.

(24) Rosen H, Glukmann V, Feldmann T, Fridman E, Lichtstein D. Short-term effects of cardiac steroids on intracellular membrane traffic in neuronal NT2 cells. Cell Mol Biol 2006;52(8):78-86.

(25) Goldstein I, Levy T, Galili D, Ovadia H, Yirmiya R, Rosen H, et al. Involvement of Na+, K+-ATPase and Endogenous Digitalis-Like Compounds in Depressive Disorders. Biol Psychiatry 2006;60(5):491-499.

(26) Deutsch J, Jang HG, Mansur N, Ilovich O, Shpolansky U, Galili D, et al. 4-(3′α15′β-dihydroxy-5′β-estran- 17′β-yl)furan-2-methyl alcohol: An anti-digoxin agent with a novel mechanism of action. J Med Chem 2006;49(2):600-606.

(27) Weidemann H, Salomon N, Avnit-Sagi T, Weidenfield J, Rosen H, Lichtsein D. Diverse effect of stress and additional adrenocorticotropic hormone on digitalis-like compounds in normal and nude mice. J Neuroendocrinol 2004;16(5):458-463.

(28) Rosen H, Glukhman V, Feldmann T, Fridman E, Lichtstein D. Cardiac Steroids Induce Changes in Recycling of the Plasma Membrane in Human NT2 Cells. Mol Biol Cell 2004;15(3):1044-1054.

(29) Meir K, Kitsberg D, Alkalay I, Szafer F, Rosen H, Shpitzen S, et al. Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis. J Biol Chem 2002;277(37):34036-34041.

(30) Lichtstein D, Rosen H. Endogenous digitalis-like Na+, K+-ATPase inhibitors, and brain function. Neurochem Res 2001;26(8-9):971-978.

(31) Segev H, Honigman A, Rosen H, Leitersdorf E. Transcriptional regulation of the human sterol 27-hydroxylase gene (CYP27) and promoter mapping. Atherosclerosis 2001;156(2):339-347.

(32) Krichevsky AM, Metzer E, Rosen H. Translational control of specific genes during differentiation of HL-60 cells. J Biol Chem 1999;274(20):14295-14305.

(33) Rosen H, Krichevsky A, Bar-Shavit Z. The enkephalinergic osteoblast. J Bone Miner Res 1998;13(10):1515-1520.

(34) Rosen H, Reshef A, Maeda N, Lippoldt A, Shpizen S, Triger L, et al. Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27- hydroxylase gene. J Biol Chem 1998;273(24):14805-14812.

(35) Ovadia H, Magenheim Y, Behar O, Rosen H. Molecular characterization of immune derived proenkephalin mRNA and the involvement of the adrenergic system in its expression in rat lymphoid cells. J Neuroimmunol 1996;68(1-2):77-83.

(36) Rosen H, Krichevsky A, Polakiewicz RD, Benzakine S, Bar-Shavit Z. Developmental regulation of proenkephalin gene expression in osteoblasts. Mol Endocrinol 1995;9(11):1621-1631.

(37) Borsook D, Falkowski O, Rosen H, Comb M, Hyman SE. Opioids modulate stress-induced proenkephalin gene expression in the hypothalamus of transgenic mice: A model of endogenous opioid gene regulation by exogenous opioids. Regul Pept 1994;54(1):29-30.

(38) Yirmiya R, Rosen H, Donchin O, Ovadia H. Behavioral effects of lipopolysaccharide in rats: involvement of endogenous opioids. Brain Res 1994;648(1):80-86.

(39) Rosen H, Bar‐Shavit Z. Dual role of osteoblastic proenkephalin derived peptides in skeletal tissues. J Cell Biochem 1994;55(3):334-339.

(40) Behar O, Ovadia H, Polakiewicz RD, Rosen H. Lipopolysaccharide induces proenkephalin gene expression in rat lymph nodes and adrenal glands. Endocrinology 1994;134(1):475-481.

(41) Borsook D, Falkowski O, Rosen H, Comb M, Hyman SE. Opioids modulate stress-induced proenkephalin gene expression in the hypothalamus of transgenic mice: A model of endogenous opioid gene regulation by exogenous opioids. J Neurosci 1994;14(12):7261-7271.

(42) Chemtov D, Rosen H. Epidemiological and cultural factors in the case of hepatitis B virus infection among Ethiopian adolescents in Israel. Int J Adolesc Med Health 1993;6(2):95-112.

(43) Rosen H, Rubinstein A. The demography of the Ethiopian community in Israel. Isr J Med Sci 1993;29(6-7):333-334.

(44) Shtarkshall R, Soskolne V, Chemtov D, Rosen H. A culturally specific educational program to reduce the risk of HIV and HBV transmission among Ethiopian immigrants to Israel. II: Evaluating the effect of the training program on veteran immigrant trainees. Isr J Med Sci 1993;29(10 SUPPL.):48-54.

(45) Chemtov D, Rosen H, Shtarkshall R, Soskolne V. A culturally specific educational program to reduce the risk of HIV and HBV transmission among Ethiopian immigrants to Israel: A preliminary report on training veteran immigrants as health educators. Isr J Med Sci 1993;29(6-7):437-442.

(46) Weinstock M, Matlina E, Maor GI, Rosen H, McEwen BS. Prenatal stress selectively alters the reactivity of the hypothalamic-pituitary adrenal system in the female rat. Brain Res 1992;595(2):195-200.

(47) Polakiewicz RD, Behar OZ, Comb MJ, Rosen H. Regulation of proenkephalin expression in cultured skin mesenchymal cells. Mol Endocrinol 1992;6(3):399-408.

(48) Borsook D, Rosen H, Collard M, Dressler H, Herrup K, Comb MJ, et al. Expression and regulation of a proenkephalin beta-galactosidase fusion gene in the reproductive system of transgenic mice. Mol Endocrinol 1992;6(9):1502-1512.

(49) Rosen H. Ethiopian Jews: An historical sketch. Isr J Med Sci 1991;27(5):242-243.

(50) Rosen H, Polakiewicz RD, Benzakine S, Bar-Shavit Z. Proenkephalin A in bone-derived cells. Proc Natl Acad Sci U S A 1991;88(9):3705-3709.

(51) Rattner A, Korner M, Rosen H, Baeuerle PA, Citri Y. Nuclear Factor κB Activates Proenkephalin Transcription in T Lymphocytes. Mol Cell Biol 1991;11(2):1017-1022.

(52) Behar OZ, Ovadia H, Polakiewicz RD, Abramsky O, Rosen H. Regulation of proenkephalin A messenger ribonucleic acid levels in normal B lymphocytes: Specific inhibition by glucocorticoid hormones and superinduction by cycloheximide. Endocrinology 1991;129(2):649-655.

(53) Rosen H, Polakiewicz RD, Simantov R. Expression of proenkephalin A mRNA and enkephalin-containing peptides in cultured fibroblasts. Biochem Biophys Res Commun 1990;171(2):722-728.

(54) Peles E, Rosen H, Darai G, Rösen-Wolff A, Becker Y. Importance of the HpaI-P sequence for herpes simplex virus-1 replication in the adrenal glands. Arch Virol 1990;113(3-4):151-163.

(55) Polakiewicz RD, Rosen H. Regulated expression of proenkephalin A during ontogenic development of mesenchymal derivative tissues. Mol Cell Biol 1990;10(2):736-742.

(56) Rosen H, Itin A, Schiff R, Keshet E. Local regulation within the female reproductive system and upon embryonic implantation: Identification of cells expressing proenkephalin A. Mol Endocrinol 1990;4(1):146-154.

(57) OVADIA H, BEHAR O, ABRAMSKY O, ROSEN H. Regulated Expression of Opioid Genes in Normal Rat Lymphocytes. Ann New York Acad Sci 1990;594(1):485-488.

(58) Rosen H, Polakiewicz RD. Increase in hypothalamic pro-opiomelanocortin gene expression in response to prolonged low level lead exposure. Brain Res 1989;493(2):380-384.

(59) Rosen H, Polakiewicz R. Postnatal expression of opioid genes in rat brain. Dev Brain Res 1989;46(1):123-129.

(60) Rosen H, Behar O, Abramsky O, Ovadia H. Regulated expression of proenkephalin A in normal lymphocytes. J Immunol 1989;143(11):3703-3707.

(61) Keshet E, Polakiewicz RD, Itin A, Ornoy A, Rosen H. Proenkephalin A is expressed in mesodermal lineages during organogenesis. EMBO J 1989;8(10):2917-2923.

(62) Civelli O, Douglass J, Rosen H. Biosynthesis of opioid peptides. NIDA RES MONOGR SER 1986;No. 70:21-42.

(63) Sagher U, Rosen H, Sarel O, Becker Y. Studies on a pancreatic cardiodepressant factor. Circ Shock 1986;19(3):319-327.

(64) Comb M, Liston D, Martin M, Rosen H, Herbert E. Expression of the human proenkephalin gene in mouse pituitary cells: accurate and efficient mRNA production and proteolytic processing. EMBO J 1985;4(12):3115-3122.

(65) Rosen H, Douglass J, Herbert E. Isolation and characterization of the rat proenkephalin gene. J Biol Chem 1984;259(22):14309-14313.

(66) Comb M, Rosen H, Seeburg P, Adelman J, Herbert E. Primary Structure of the Human Proenkephalin Gene. DNA 1983;2(3):213-229.

(67) Herbert E, Oates E, Martens G, Comb M, Rosen H, Uhler M. Generation of diversity and evolution of opioid peptides. Cold Spring Harb Symp Quant Biol 1983;48 Pt 1:375-384.

(68) Yarom R, Sagher U, Rosen H, Becker Y, More R, Chandler JA. Effect of extracts from ischemic pancreas (myocardial depressant factor?) on platelets. Isr J Med Sci 1982;18(6):689-694.

(69) Rosen H, Di Segni G, Kaempfer R. Translational control by messenger RNA competition for eukaryotic initiation factor 2. J Biol Chem 1982;257(2):946-952.

(70) Rosen H, Knoller S, Kaempfer R. Messenger Ribonucleic Acid Specificity in the Inhibition of Eukaryotic Translation by Double-Stranded Ribonucleic Acid. Biochemistry 1981;20(11):3011-3020.

(71) Rosen H, Kaempfer R. Mutually exclusive binding of messenger RNA and initiator methionyl transfer RNA to eukaryotic initiation factor 2. Biochem Biophys Res Commun 1979;91(2):449-455.

(72) Segni GD, Rosen H, Kaempfer R. Competition between α- and β-Globin Messenger Ribonucleic Acids for Eucaryotic Initiation Factor 2. Biochemistry 1979;18(13):2847-2854.

(73) Kaempfer R, Rosen H, Israeli R. Translational control: Recognition of the methylated 5' end and an internal sequence in eukaryotic mRNA by the initiation factor that binds methionyl-tRNA(f)(met). Proc Natl Acad Sci U S A 1978;75(2):650-654.

(74) Zilkha A, Rosen H, Gertner D. Kinetics of the amine-initiated polymerization of a six-membered N-carboxy anhydride. Eur Polym J 1967;3(1):13-24.

(75) Gertner D, Rosen H, Zilkha A. Syntheses of Some Silicon‐Containing β‐Amino Acids. Isr J Chem 1965;3(6):235-238.