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The Faculty of Medicine - Medical Neurobiology: Binshtok Alex

Researchers

Last updated December 2021 - Medical Neurobiology

List of Publications

(1) Aleixandre-Carrera F, Engelmayer N, Ares-Suárez D, Acosta MC, Belmonte C, Gallar J, et al. Optical assessment of nociceptive TRP channel function at the peripheral nerve terminal. Int J Mol Sci 2021;22(2):1-20.

(2) Barkai O, Butterman R, Katz B, Lev S, Binshtok AM. The Input-Output Relation of Primary Nociceptive Neurons is Determined by the Morphology of the Peripheral Nociceptive Terminals. J Neurosci 2020;40(49):9346-9363.

(3) Leibovich H, Buzaglo N, Tsuriel S, Peretz L, Caspi Y, Katz B, et al. Abnormal Reinnervation of Denervated Areas Following Nerve Injury Facilitates Neuropathic Pain. Cells 2020;9(4).

(4) Barkai O, Puig S, Lev S, Title B, Katz B, Eli-Berchoer L, et al. Platelet-derived growth factor activates nociceptive neurons by inhibiting M-current and contributes to inflammatory pain. Pain 2019;160(6):1281-1296.

(5) Goldstein RH, Barkai O, Íñigo-Portugués A, Katz B, Lev S, Binshtok AM. Location and Plasticity of the Sodium Spike Initiation Zone in Nociceptive Terminals In Vivo. Neuron 2019;102(4):801-812.e5.

(6) Neumann-Raizel H, Shilo A, Lev S, Mogilevsky M, Katz B, Shneor D, et al. 2-APB and CBD-mediated targeting of charged cytotoxic compounds into tumor cells suggests the involvement of TRPV2 channels. Front Pharmacol 2019;10.

(7) Gershkovitz M, Caspi Y, Fainsod-Levi T, Katz B, Michaeli J, Khawaled S, et al. TRPM2 mediates neutrophil killing of disseminated tumor cells. Cancer Res 2018;78(10):2680-2690.

(8) Stueber T, Eberhardt MJ, Caspi Y, Lev S, Binshtok A, Leffler A. Differential cytotoxicity and intracellular calcium-signalling following activation of the calcium-permeable ion channels TRPV1 and TRPA1. Cell Calcium 2017;68:34-44.

(9) Goldstein RH, Katz B, Lev S, Binshtok AM. Ultrafast optical recording reveals distinct capsaicin-induced ion dynamics along single nociceptive neurite terminals in vitro. J Biomed Opt 2017;22(7).

(10) Barkai O, Goldstein RH, Caspi Y, Katz B, Lev S, Binshtok AM. The role of Kv7/M potassium channels in controlling ectopic firing in nociceptors. Front Mol Neurosci 2017;10.

(11) Cohn Yakubovich D, Eliav U, Yalon E, Schary Y, Sheyn D, Cook-Wiens G, et al. Teriparatide attenuates scarring around murine cranial bone allograft via modulation of angiogenesis. Bone 2017;97:192-200.

(12) Tzour A, Leibovich H, Barkai O, Biala Y, Lev S, Yaari Y, et al. KV7/M channels as targets for lipopolysaccharide-induced inflammatory neuronal hyperexcitability. J Physiol 2017;595(3):713-738.

(13) Nita II, Caspi Y, Gudes S, Fishman D, Lev S, Hersfinkel M, et al. Privileged crosstalk between TRPV1 channels and mitochondrial calcium shuttling machinery controls nociception. Biochim Biophys Acta Mol Cell Res 2016;1863(12):2868-2880.

(14) Stueber T, Eberhardt MJ, Hadamitzky C, Jangra A, Schenk S, Dick F, et al. Quaternary lidocaine derivative QX-314 activates and permeates human TRPV1 and TRPA1 to produce inhibition of sodium channels and cytotoxicity. Anesthesiology 2016;124(5):1153-1165.

(15) Tsuriel S, Gudes S, Draft RW, Binshtok AM, Lichtman JW. Multispectral labeling technique to map many neighboring axonal projections in the same tissue. Nat Methods 2015;12(6):547-552.

(16) Gudes S, Barkai O, Caspi Y, Katz B, Lev S, Binshtok AM. The role of slow and persistent ttx-resistant sodium currents in acute tumor necrosis factor- α-mediated increase in nociceptors excitability. J Neurophysiol 2015;113(2):601-619.

(17) Puopolo M, Binshtok AM, Yao G-, Oh SB, Woolf CJ, Bean BP. Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314. J Neurophysiol 2013;109(7):1704-1712.

(18) Ginosar Y, Binshtok AM. In reply. Anesthesiology 2013;118(4):985-986.

(19) Roberson DP, Gudes S, Sprague JM, Patoski HAW, Robson VK, Blasl F, et al. Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons. Nat Neurosci 2013;16(7):910-918.

(20) Zakir HM, Mostafeezur RM, Suzuki A, Hitomi S, Suzuki I, Maeda T, et al. Expression of TRPV1 Channels after Nerve Injury Provides an Essential Delivery Tool for Neuropathic Pain Attenuation. PLoS ONE 2012;7(9).

(21) Ginosar Y, Binshtok AM. Mechanisms in anesthesia and analgesia: Convention, crisis, and the shoulders of giants. Anesthesiology 2012;117(3):451-453.

(22) Roberson DP, Binshtok AM, Blasl F, Bean BP, Woolf CJ. Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: A systematic study and review. Br J Pharmacol 2011;164(1):48-58.

(23) Binshtok AM. Mechanisms of Nociceptive Transduction and Transmission: A Machinery for Pain Sensation and Tools for Selective Analgesia. Int Rev Neurobiol 2011;97:143-177.

(24) Kim HY, Kim K, Li HY, Chung G, Park C-, Kim JS, et al. Selectively targeting pain in the trigeminal system. Pain 2010;150(1):29-40.

(25) Dib-Hajj SD, Binshtok AM, Cummins TR, Jarvis MF, Samad T, Zimmermann K. Voltage-gated sodium channels in pain states: Role in pathophysiology and targets for treatment. Brain Res Rev 2009;60(1):65-83.

(26) Binshtok AM, Gerner P, Oh SB, Puopolo M, Suzuki S, Roberson DP, et al. Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents. Anesthesiology 2009;111(1):127-137.

(27) Binshtok AM, Wang H, Zimmermann K, Amaya F, Vardeh D, Shi L, et al. Nociceptors are interleukin-1β sensors. J Neurosci 2008;28(52):14062-14073.

(28) Gerner P, Binshtok AM, Wang C-, Hevelone ND, Bean BP, Woolf CJ, et al. Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve. Anesthesiology 2008;109(5):872-878.

(29) Binshtok AM, Bean BP, Woolf CJ. Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Nature 2007;449(7162):607-610.

(30) Kim DY, Carey BW, Wang H, Ingano LAM, Binshtok AM, Wertz MH, et al. BACE1 regulates voltage-gated sodium channels and neuronal activity. Nature Cell Biol 2007;9(7):755-764.

(31) Tegeder I, Costigan M, Griffin RS, Abele A, Belfer I, Schmidt H, et al. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med 2006;12(11):1269-1277.

(32) Binshtok AM, Fleidervish IA, Sprengel R, Gutnick MJ. NMDA receptors in layer 4 spiny stellate cells of the mouse barrel cortex contain the NR2C subunit. J Neurosci 2006;26(2):708-715.

(33) Fleidervish IA, Binshtok AM, Gutnick MJ. Functionally distinct NMDA receptors mediate horizontal connectivity within Layer 4 of mouse barrel cortex. Neuron 1998;21(5):1055-1065.