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The Faculty of Medicine - Medical Neurobiology: Goldberg Josh


Last updated February 2023 - Medical Neurobiology

List of Publications

(1) Osnat O, Matityahu L, Mizrahi-Kliger A, Kaplan A, Berkowitz N, Tiroshi L, et al. Non-uniform distribution of dendritic nonlinearities differentially engages thalamostriatal and corticostriatal inputs onto cholinergic interneurons. eLife 2022;11.

(2) Matityahu L, Malgady JM, Schirelman M, Johansson Y, Wilking JA, Silberberg G, et al. A tonic nicotinic brake controls spike timing in striatal spiny projection neurons. eLife 2022;11.

(3) Chiu W-, Kovacheva L, Musgrove RE, Arien-Zakay H, Koprich JB, Brotchie JM, et al. α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms. Sci Adv 2021;7(11).

(4) Thakur P, Chiu WH, Roeper J, Goldberg JA. α-Synuclein 2.0 — Moving towards Cell Type Specific Pathophysiology. Neuroscience 2019;412:248-256.

(5) Plotkin JL, Goldberg JA. Thinking Outside the Box (and Arrow): Current Themes in Striatal Dysfunction in Movement Disorders. Neuroscientist 2019;25(4):359-379.

(6) Aceves Buendia JJ, Tiroshi L, Chiu W-, Goldberg JA. Selective remodeling of glutamatergic transmission to striatal cholinergic interneurons after dopamine depletion. Eur J Neurosci 2019;49(6):824-833.

(7) Tiroshi L, Goldberg JA. Population dynamics and entrainment of basal ganglia pacemakers are shaped by their dendritic arbors. PLoS Comput Biol 2019;15(2).

(8) Rehani R, Atamna Y, Tiroshi L, Chiu W-, Aceves Buendía JJ, Martins GJ, et al. Activity patterns in the neuropil of striatal cholinergic interneurons in freely moving mice represent their collective spiking dynamics. eNeuro 2019;6(1).

(9) Lasser-Katz E, Simchovitz A, Chiu W-, Oertel WH, Sharon R, Soreq H, et al. Mutant α -synuclein overexpression induces stressless pacemaking in vagal motoneurons at risk in parkinson’s disease. J Neurosci 2017;37(1):47-57.

(10) Tanimura A, Lim SAO, Buendia JJA, Goldberg JA, Surmeier DJ. Cholinergic interneurons amplify corticostriatal synaptic responses in the Q175 model of huntington’s disease. Front Syst Neurosci 2016;10(DEC).

(11) Estep CM, Galtieri DJ, Zampese E, Goldberg JA, Brichta L, Greengard P, et al. Transient activation of GABAB receptors suppresses SK channel currents in substantia nigra pars compacta dopaminergic neurons. PLoS ONE 2016;11(12).

(12) Deffains M, Adler A, Joshua M, Goldberg JA, Morris G, Bergman H. Basal ganglia: Acetylcholine interactions and behavior. The Curated Reference Collection in Neuroscience and Biobehavioral Psychology; 2016.

(13) Goldberg JA, Wilson CJ. The Cholinergic Interneuron of the Striatum. Handb Behav Neurosci 2016;24:137-155.

(14) Cooper G, Lasser-Katz E, Simchovitz A, Sharon R, Soreq H, James Surmeier D, et al. Functional segregation of voltage-activated calcium channels in motoneurons of the dorsal motor nucleus of the vagus. J Neurophysiol 2015;114(3):1513-1520.

(15) Goldberg JA, Atherton JF, James Surmeier D. Spectral reconstruction of phase response curves reveals the synchronization properties of mouse globus pallidus neurons. J Neurophysiol 2013;110(10):2497-2506.

(16) Goldberg JA, Guzman JN, Estep CM, Ilijic E, Kondapalli J, Sanchez-Padilla J, et al. Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson's disease. Nat Neurosci 2012;15(10):1414-1421.

(17) Goldberg JA, Ding JB, Surmeier DJ. Muscarinic modulation of striatal function and circuitry. Handb Exp Pharmacol 2012;208:223-241.

(18) Peterson JD, Goldberg JA, Surmeier DJ. Adenosine A2a receptor antagonists attenuate striatal adaptations following dopamine depletion. Neurobiol Dis 2012;45(1):409-416.

(19) Goldberg JA, Bergman H. Computational physiology of the neural networks of the primate globus pallidus: Function and dysfunction. Neuroscience 2011;198:171-192.

(20) Goldberg JA, Reynolds JNJ. Spontaneous firing and evoked pauses in the tonically active cholinergic interneurons of the striatum. Neuroscience 2011;198:27-43.

(21) Anholt TA, Ayal S, Goldberg JA. Recruitment and blocking properties of the CardioFit stimulation lead. J Neural Eng 2011;8(3).

(22) Surmeier DJ, Guzman JN, Sanchez-Padilla J, Goldberg JA. The origins of oxidant stress in parkinson's disease and therapeutic strategies. Antioxid Redox Signal 2011;14(7):1289-1301.

(23) Ding JB, Guzman JN, Peterson JD, Goldberg JA, Surmeier DJ. Thalamic gating of corticostriatal signaling by cholinergic interneurons. Neuron 2010;67(2):294-307.

(24) Rowland NC, Goldberg JA, Jaeger D. Cortico-cerebellar coherence and causal connectivity during slow-wave activity. Neuroscience 2010;166(2):698-711.

(25) Goldberg JA, Wilson CJ. The Cholinergic Interneurons of the Striatum: Intrinsic Properties Underlie Multiple Discharge Patterns. Handb Behav Neurosci 2010;20(C):133-149.

(26) Surmeier DJ, Guzman JN, Sanchez-Padilla J, Goldberg JA. What causes the death of dopaminergic neurons in Parkinson's disease? Prog Brain Res 2010;183(C):59-77.

(27) Goldberg JA, Teagarden MA, Foehring RC, Wilson CJ. Nonequilibrium calcium dynamics regulate the autonomous firing pattern of rat striatal cholinergic interneurons. J Neurosci 2009;29(26):8396-8407.

(28) Adler A, Joshoua M, Bergman H, Goldberg JA, Morris G. Basal Ganglia: Acetylcholine Interactions and Behavior. Encyclopedia of Neuroscience; 2009. p. 63-66.

(29) Li S, Arbuthnott GW, Jutras MJ, Goldberg JA, Jaeger D. Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation. J Neurophysiol 2007;98(6):3525-3537.

(30) Elias S, Joshua M, Goldberg JA, Heimer G, Arkadir D, Morris G, et al. Statistical properties of pauses of the high-frequency discharge neurons in the external segment of the globus pallidus. J Neurosci 2007;27(10):2525-2538.

(31) Goldberg JA, Deister CA, Wilson CJ. Response properties and synchronization of rhythmically firing dendritic neurons. J Neurophysiol 2007;97(1):208-219.

(32) Heimer G, Rivlin-Etzion M, Bar-Gad I, Goldberg JA, Haber SN, Bergman H. Dopamine replacement therapy does not restore the full spectrum of normal pallidal activity in the 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine primate model of Parkinsonism. J Neurosci 2006;26(31):8101-8114.

(33) Ding J, Guzman JN, Tkatch T, Chen S, Goldberg JA, Ebert PJ, et al. RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion. Nat Neurosci 2006;9(6):832-842.

(34) Wilson CJ, Goldberg JA. Origin of the slow afterhyperpolarization and slow rhythmic bursting in striatal cholinergic interneurons. J Neurophysiol 2006;95(1):196-204.

(35) Goldberg JA, Wilson CJ. Control of spontaneous firing patterns by the selective coupling of calcium currents to calcium-activated potassium currents in striatal cholinergic interneurons. J Neurosci 2005;25(44):10230-10238.

(36) Hutchison WD, Dostrovsky JO, Walters JR, Courtemanche R, Boraud T, Goldberg J, et al. Neuronal oscillations in the basal ganglia and movement disorders: Evidence from whole animal and human recordings. J Neurosci 2004;24(42):9240-9243.

(37) Goldberg JA, Rokni U, Boraud T, Vaadia E, Bergman H. Spike synchronization in the cortex-basal ganglia networks of parkinsonian primates reflects global dynamics of the local field potentials. J Neurosci 2004;24(26):6003-6010.

(38) Goldberg JA, Rokni U, Sompolinsky H. Patterns of ongoing activity and the functional architecture of the primary visual cortex. Neuron 2004;42(3):489-500.

(39) Goldberg JA, Kats SS, Jaeger D. Globus Pallidus Discharge is Coincident with Striatal Activity during Global Slow Wave Activity in the Rat. J Neurosci 2003;23(31):10058-10063.

(40) Heimer G, Bar-Gad I, Goldberg JA, Bergman H. Dopamine replacement therapy reverses abnormal synchronization of pallidal neurons in the 1-methyl-4-phenyll-1,2,3,6-tetrahydropyridine primate model of parkinsonism. J Neurosci 2002;22(18):7850-7855.

(41) Goldberg JA, Boraud T, Maraton S, Haber SN, Vaadia E, Bergman H. Enhanced Synchrony among Primary Motor Cortex Neurons in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Primate Model of Parkinson's Disease. J Neurosci 2002;22(11):4639-4653.

(42) Ben-Pazi H, Bergman H, Goldberg JA, Giladi N, Hansel D, Reches A, et al. Synchrony of rest tremor in multiple limbs in Parkinson's disease: Evidence for multiple oscillators. J Neural Transm 2001;108(3):287-296.

(43) Bar-Gad I, Goldberg JA, Bergman H, Havazelet-Heimer G, Ruppin E. Reinforcement-Driven Dimensionality Reduction- A Model For Information Processing In The Basal Ganglia. J Basic Clin Physiol Pharmacol 2000;11(4):305-320.