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The Faculty of Medicine - Medical Neurobiology: Klar Avihu


Last updated December 2021 - Medical Neurobiology

List of Publications

(1) Haimson B, Hadas Y, Bernat N, Kania A, Daley M, Cinnamon Y, et al. Spinal lumbar di2 interneurons contribute to stability of bipedal stepping. eLife 2021;10.

(2) Haimson B, Meir O, Sudakevitz-Merzbach R, Elberg G, Friedrich S, Lovell PV, et al. Natural loss of function of ephrin-B3 shapes spinal flight circuitry in birds. Sci Adv 2021;7(24).

(3) Wang X, Kohl A, Yu X, Zorio DAR, Klar A, Sela-Donenfeld D, et al. Temporal-specific roles of fragile X mental retardation protein in the development of the hindbrain auditory circuit. Development 2020;147(21).

(4) Lahaie S, Morales D, Bagci H, Hamoud N, Castonguay C-, Kazan JM, et al. The endosomal sorting adaptor HD-PTP is required for ephrin-B:EphB signalling in cellular collapse and spinal motor axon guidance. Sci Rep 2019;9(1).

(5) Cohen O, Vald L, Yamagata M, Sanes JR, Klar A. Roles of DSCAM in axonal decussation and fasciculation of chick spinal interneurons. Int J Dev Biol 2017;61(3-5):235-244.

(6) Kohl A, Marquardt T, Klar A, Sela-Donenfeld D. Control of axon guidance and neurotransmitter phenotype of dB1 hindbrain interneurons by Lim-HD code. J Neurosci 2015;35(6):2596-2611.

(7) Hadas Y, Etlin A, Falk H, Avraham O, Kobiler O, Panet A, et al. A 'tool box' for deciphering neuronal circuits in the developing chick spinal cord. Nucleic Acids Res 2014;42(19).

(8) Mansour AA, Khazanov-Zisman S, Netser Y, Klar A, Ben-Arie N. Nato3 plays an integral role in dorsoventral patterning of the spinal cord by segregating floor plate/p3 fates via Nkx2.2 suppression and Foxa2 maintenance. Development 2014;141(3):574-584.

(9) Escalante A, Murillo B, Morenilla-Palao C, Klar A, Herrera E. Zic2-dependent axon midline avoidance controls the formation of major ipsilateral tracts in the CNS. Neuron 2013;80(6):1392-1406.

(10) Hadas Y, Nitzan N, Furley AJW, Kozlov SV, Klar A. Distinct Cis Regulatory Elements Govern the Expression of TAG1 in Embryonic Sensory Ganglia and Spinal Cord. PLoS ONE 2013;8(2).

(11) Kohl A, Hadas Y, Klar A, Sela-Donenfeld D. Electroporation of the hindbrain to trace axonal trajectories and synaptic targets in the chick embryo. J Vis Exp 2013(75).

(12) Nitzan E, Krispin S, Pfaltzgraff ER, Klar A, Labosky PA, Kalcheim C. A dynamic code of dorsal neural tube genes regulates the segregation between neurogenic and melanogenic neural crest cells. Development 2012;140(11):2269-2279.

(13) Kohl A, Hadas Y, Klar A, Sela-Donenfeld D. Axonal patterns and targets of dA1 interneurons in the chick hindbrain. J Neurosci 2012;32(17):5757-5771.

(14) Peterziel H, Sackmann T, Strelau J, Kuhn PH, Lichtenthaler SF, Marom K, et al. F-spondin regulates neuronal survival through activation of disabled-1 in the chicken ciliary ganglion. Mol Cell Neurosci 2011;46(2):483-497.

(15) Mansour AA, Nissim-Eliraz E, Zisman S, Golan-Lev T, Schatz O, Klar A, et al. Foxa2 regulates the expression of Nato3 in the floor plate by a novel evolutionarily conserved promoter. Mol Cell Neurosci 2011;46(1):187-199.

(16) Avraham O, Hadas Y, Vald L, Hong S, Song M-, Klar A. Motor and dorsal root ganglion axons serve as choice points for the ipsilateral turning of dI3 axons. J Neurosci 2010;30(46):15546-15557.

(17) Avraham O, Zisman S, Hadas Y, Vald L, Klar A. Deciphering axonal pathways of genetically defined groups of neurons in the chick neural tube utilizing in ovo electroporation. J Visualized Exp 2010(39).

(18) Palmesino E, Rousso DL, Kao T-, Klar A, Laufer E, Uemura O, et al. Foxp1 and Lhx1 coordinate motor neuron migration with axon trajectory choice by gating reelin signalling. PloS Biol 2010;8(8):41-42.

(19) Meyuhas R, Pikarsky E, Tavor E, Klar A, Abramovitch R, Hochman J, et al. A key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1(CYR61) in tumor cells. Mol Cancer Res 2008;6(9):1397-1409.

(20) Zisman S, Marom K, Avraham O, Rinsky-Halivni L, Gai U, Kligun G, et al. Proteolysis and membrane capture of F-spondin generates combinatorial guidance cues from a single molecule. J Cell Biol 2007;178(7):1237-1249.

(21) Schubert D, Klar A, Park M, Dargusch R, Fischer WH. F-spondin promotes nerve precursor differentiation. J Neurochem 2006;96(2):444-453.

(22) Feinstein Y, Klar A. The neuronal class 2 TSR proteins F-spondin and Mindin: A small family with divergent biological activities. Int J Biochem Cell Biol 2004;36(6):975-980.

(23) Jin Z, Zhang J, Klar A, Chédotal A, Rao Y, Cepko CL, et al. Irx4-mediated regulation of Slit1 expression contributes to the definition of early axonal paths inside the retina. Development (Cambridge) 2003;130(6):1037-1048.

(24) Mirski R, Reichert F, Klar A, Rotshenker S. Granulocyte macrophage colony stimulating factor (GM-CSF) activity is regulated by a GM-CSF binding molecule in Wallerian degeneration following injury to peripheral nerve axons. J Neuroimmunol 2003;140(1-2):88-96.

(25) Tzarfaty-Majar V, López-Alemany R, Feinstein Y, Gombau L, Goldshmidt O, Soriano E, et al. Plasmin-mediated Release of the Guidance Molecule F-spondin from the Extracellular Matrix. J Biol Chem 2001;276(30):28233-28241.

(26) Tzarfati-Majar V, Burstyn-Cohen T, Klar A. F-spondin is a contact-repellent molecule for embryonic motor neurons. Proc Natl Acad Sci U S A 2001;98(8):4722-4727.

(27) Burstyn-Cohen T, Tzarfaty V, Frumkin A, Feinstein Y, Stoeckli E, Klar A. F-spondin is required for accurate pathfinding of commissural axons at the floor plate. Neuron 1999;23(2):233-246.

(28) Debby-Brafman A, Burstyn-Cohen T, Klar A, Kalcheim C. F-spondin, expressed in somite regions avoided by neural crest cells, mediates inhibition of distinct somite domains to neural crest migration. Neuron 1999;22(3):475-488.

(29) Feinstein Y, Borrell V, Garcia C, Burstyn-Cohen T, Tzarfaty V, Frumkin A, et al. F-spondin and mindin: Two structurally and functionally related genes expressed in the hippocampus that promote outgrowth of embryonic hippocampal neurons. Development (Cambridge) 1999;126(16):3637-3648.

(30) Burstyn-Cohen T, Frumkin A, Xu Y-, Scherer SS, Klar A. Accumulation of F-spondin in injured peripheral nerve promotes the outgrowth of sensory axons. J Neurosci 1998;18(21):8875-8885.

(31) Ben-Shushan E, Pikarsky E, Klar A, Bergman Y. Extinction of Oct-3/4 gene expression in embryonal carcinoma x fibroblast somatic cell hybrids is accompanied by changes in the methylation status, chromatin structure, and transcriptional activity of the Oct-3/4 upstream region. Mol Cell Biol 1993;13(2):891-901.

(32) Altaba ARI, Cox C, Jessell TM, Klar A. Ectopic neural expression of a floor plate marker in frog embryos injected with the midline transcription factor Pintallavis. Proc Natl Acad Sci U S A 1993;90(17):8268-8272.

(33) Klar A, Baldassare M, Jessell TM. F-spondin: A gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension. Cell 1992;69(1):95-110.

(34) Klar A, Jessell TM, Altaba ARI. Control of floor plate identity and function in the embryonic nervous system. COLD SPRING HARBOR SYMP QUANT BIOL 1992;57:473-482.

(35) Handeli S, Klar A, Meuth M, Cedar H. Mapping replication units in animal cells. Cell 1989;57(6):909-920.