Skip to Main Content
It looks like you're using Internet Explorer 11 or older. This website works best with modern browsers such as the latest versions of Chrome, Firefox, Safari, and Edge. If you continue with this browser, you may see unexpected results.

The Faculty of Medicine - Medical Neurobiology: Kupchik Yonatan


Last updated December 2021 - Medical Neurobiology

List of Publications

(1) Gendelis S, Inbar D, Kupchik YM. The role of the nucleus accumbens and ventral pallidum in feeding and obesity. Prog Neuro-Psychopharmacol Biol Psychiatry 2021;111.

(2) Kupchik YM, Prasad AA. Ventral pallidum cellular and pathway specificity in drug seeking. Neurosci Biobehav Rev 2021;131:373-386.

(3) Gendelis S, Inbar D, Inbar K, Mesner S, Kupchik YM. Metaplasticity in the ventral pallidum as a potential marker for the propensity to gain weight in chronic high-calorie diet. J Neurosci 2020;40(50):9725-9735.

(4) Namba MD, Kupchik YM, Spencer SM, Garcia-Keller C, Goenaga JG, Powell GL, et al. Accumbens neuroimmune signaling and dysregulation of astrocytic glutamate transport underlie conditioned nicotine-seeking behavior. Addict Biol 2020;25(5).

(5) Levi LA, Inbar K, Nachshon N, Bernat N, Gatterer A, Inbar D, et al. Projection-specific potentiation of ventral pallidal glutamatergic outputs after abstinence from cocaine. J Neurosci 2020;40(20):1276-1285.

(6) Inbar D, Gendelis S, Mesner S, Menahem S, Kupchik YM. Chronic calorie-dense diet drives differences in motivated food seeking between obesity-prone and resistant mice. Addict Biol 2020;25(3).

(7) Inbar K, Levi LA, Bernat N, Odesser T, Inbar D, Kupchik YM. Cocaine dysregulates dynorphin modulation of inhibitory neurotransmission in the ventral pallidum in a cell-type-specific manner. J Neurosci 2020;40(6):1321-1331.

(8) Brown RM, Kupchik YM, Spencer S, Garcia-Keller C, Spanswick DC, Lawrence AJ, et al. Addiction-like Synaptic Impairments in Diet-Induced Obesity. Biol Psychiatry 2017;81(9):797-806.

(9) Heinsbroek JA, Neuhofer DN, Griffin WC, Siegel GS, Bobadilla A-, Kupchik YM, et al. Loss of plasticity in the D2-accumbens pallidal pathway promotes cocaine seeking. J Neurosci 2017;37(4):757-767.

(10) Kupchik YM, Kalivas PW. The Direct and Indirect Pathways of the Nucleus Accumbens are not What You Think. Neuropsychopharmacology 2017;42(1):369-370.

(11) Garcia-Keller C, Kupchik YM, Gipson CD, Brown RM, Spencer S, Bollati F, et al. Glutamatergic mechanisms of comorbidity between acute stress and cocaine self-administration. Mol Psychiatry 2016;21(8):1063-1069.

(12) Scofield MD, Heinsbroek JA, Gipson CD, Kupchik YM, Spencer S, Smith ACW, et al. The nucleus accumbens: Mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis. Pharmacol Rev 2016;68(3):816-871.

(13) Stefanik MT, Kupchik YM, Kalivas PW. Optogenetic inhibition of cortical afferents in the nucleus accumbens simultaneously prevents cue-induced transient synaptic potentiation and cocaine-seeking behavior. Brain Struct Funct 2016;221(3):1681-1689.

(14) Kupchik YM, Brown RM, Heinsbroek JA, Lobo MK, Schwartz DJ, Kalivas PW. Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections. Nat Neurosci 2015;18(9):1230-1232.

(15) Kupchik YM, Scofield MD, Rice KC, Cheng K, Roques BP, Kalivas PW. Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum. J Neurosci 2014;34(3):1057-1066.

(16) Smith ACW, Kupchik YM, Scofield MD, Gipson CD, Wiggins A, Thomas CA, et al. Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases. Nat Neurosci 2014;17(12):1655-1657.

(17) Spencer S, Brown RM, Quintero GC, Kupchik YM, Thomas CA, Reissner KJ, et al. α2δ-1 signaling in nucleus accumbens is necessary for cocaine-induced relapse. J Neurosci 2014;34(25):8605-8611.

(18) Gipson CD, Kupchik YM, Kalivas PW. Rapid, transient synaptic plasticity in addiction. Neuropharmacology 2014;76(PART B):276-286.

(19) Kupchik YM, Kalivas PW. The rostral subcommissural ventral pallidum is a mix of ventral pallidal neurons and neurons from adjacent areas: An electrophysiological study. Brain Struct Funct 2013;218(6):1487-1500.

(20) Stefanik MT, Kupchik YM, Brown RM, Kalivas PW. Optogenetic evidence that pallidal projections, not nigral projections, from the nucleus accumbens core are necessary for reinstating cocaine seeking. J Neurosci 2013;33(34):13654-13662.

(21) Gipson CD, Reissner KJ, Kupchik YM, Smith ACW, Stankeviciute N, Hensley-Simon ME, et al. Reinstatement of nicotine seeking is mediated by glutamatergic plasticity. Proc Natl Acad Sci U S A 2013;110(22):9124-9129.

(22) Brown RM, Kupchik YM, Kalivas PW. The story of glutamate in drug addiction and of N-acetylcysteine as a potential pharmacotherapy. JAMA Psychiatry 2013;70(9):895-897.

(23) Gipson CD, Kupchik YM, Shen H, Reissner KJ, Thomas CA, Kalivas PW. Relapse induced by cues predicting cocaine depends on rapid, transient synaptic potentiation. Neuron 2013;77(5):867-872.

(24) Stefanik MT, Moussawi K, Kupchik YM, Smith KC, Miller RL, Huff ML, et al. Optogenetic inhibition of cocaine seeking in rats. Addict Biol 2013;18(1):50-53.

(25) Kupchik YM, Moussawi K, Tang X-, Wang X, Kalivas BC, Kolokithas R, et al. The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine. Biol Psychiatry 2012;71(11):978-986.

(26) Kupchik YM, Parnas H, Parnas I. A novel, extremely fast, feedback inhibition of glutamate release in the crayfish neuromuscular junction. Neuroscience 2011;172:44-54.

(27) Kupchik YM, Barchad-Avitzur O, Wess J, Ben-Chaim Y, Parnas I, Parnas H. A novel fast mechanism for GPCR-mediated signal transduction - Control of neurotransmitter release. J Cell Biol 2011;192(1):137-151.

(28) Kupchik YM, Rashkovan G, Ohana L, Keren-Raifman T, Dascal N, Parnas H, et al. Molecular mechanisms that control initiation and termination of physiological depolarization-evoked transmitter release. Proc Natl Acad Sci U S A 2008;105(11):4435-4440.