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The Faculty of Medicine - Medical Neurobiology: Kupchik Yonatan

Researchers

 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Gendelis S, Inbar D, Inbar K, Mesner S, Kupchik YM. Metaplasticity in the ventral pallidum as a potential marker for the propensity to gain weight in chronic high-calorie diet. J Neurosci 2020;40(50):9725-9735.

(2) Namba MD, Kupchik YM, Spencer SM, Garcia-Keller C, Goenaga JG, Powell GL, et al. Accumbens neuroimmune signaling and dysregulation of astrocytic glutamate transport underlie conditioned nicotine-seeking behavior. Addict Biol 2020;25(5).

(3) Levi LA, Inbar K, Nachshon N, Bernat N, Gatterer A, Inbar D, et al. Projection-specific potentiation of ventral pallidal glutamatergic outputs after abstinence from cocaine. J Neurosci 2020;40(20):1276-1285.

(4) Inbar D, Gendelis S, Mesner S, Menahem S, Kupchik YM. Chronic calorie-dense diet drives differences in motivated food seeking between obesity-prone and resistant mice. Addict Biol 2020;25(3).

(5) Inbar K, Levi LA, Bernat N, Odesser T, Inbar D, Kupchik YM. Cocaine dysregulates dynorphin modulation of inhibitory neurotransmission in the ventral pallidum in a cell-type-specific manner. J Neurosci 2020;40(6):1321-1331.

(6) Brown RM, Kupchik YM, Spencer S, Garcia-Keller C, Spanswick DC, Lawrence AJ, et al. Addiction-like Synaptic Impairments in Diet-Induced Obesity. Biol Psychiatry 2017;81(9):797-806.

(7) Heinsbroek JA, Neuhofer DN, Griffin WC, Siegel GS, Bobadilla A-, Kupchik YM, et al. Loss of plasticity in the D2-accumbens pallidal pathway promotes cocaine seeking. J Neurosci 2017;37(4):757-767.

(8) Kupchik YM, Kalivas PW. The Direct and Indirect Pathways of the Nucleus Accumbens are not What You Think. Neuropsychopharmacology 2017;42(1):369-370.

(9) Garcia-Keller C, Kupchik YM, Gipson CD, Brown RM, Spencer S, Bollati F, et al. Glutamatergic mechanisms of comorbidity between acute stress and cocaine self-administration. Mol Psychiatry 2016;21(8):1063-1069.

(10) Scofield MD, Heinsbroek JA, Gipson CD, Kupchik YM, Spencer S, Smith ACW, et al. The nucleus accumbens: Mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis. Pharmacol Rev 2016;68(3):816-871.

(11) Stefanik MT, Kupchik YM, Kalivas PW. Optogenetic inhibition of cortical afferents in the nucleus accumbens simultaneously prevents cue-induced transient synaptic potentiation and cocaine-seeking behavior. Brain Struct Funct 2016;221(3):1681-1689.

(12) Kupchik YM, Brown RM, Heinsbroek JA, Lobo MK, Schwartz DJ, Kalivas PW. Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections. Nat Neurosci 2015;18(9):1230-1232.

(13) Kupchik YM, Scofield MD, Rice KC, Cheng K, Roques BP, Kalivas PW. Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum. J Neurosci 2014;34(3):1057-1066.

(14) Gipson CD, Kupchik YM, Kalivas PW. Rapid, transient synaptic plasticity in addiction. Neuropharmacology 2014;76(PART B):276-286.

(15) Smith ACW, Kupchik YM, Scofield MD, Gipson CD, Wiggins A, Thomas CA, et al. Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases. Nat Neurosci 2014;17(12):1655-1657.

(16) Spencer S, Brown RM, Quintero GC, Kupchik YM, Thomas CA, Reissner KJ, et al. α2δ-1 signaling in nucleus accumbens is necessary for cocaine-induced relapse. J Neurosci 2014;34(25):8605-8611.

(17) Kupchik YM, Kalivas PW. The rostral subcommissural ventral pallidum is a mix of ventral pallidal neurons and neurons from adjacent areas: An electrophysiological study. Brain Struct Funct 2013;218(6):1487-1500.

(18) Stefanik MT, Kupchik YM, Brown RM, Kalivas PW. Optogenetic evidence that pallidal projections, not nigral projections, from the nucleus accumbens core are necessary for reinstating cocaine seeking. J Neurosci 2013;33(34):13654-13662.

(19) Gipson CD, Reissner KJ, Kupchik YM, Smith ACW, Stankeviciute N, Hensley-Simon ME, et al. Reinstatement of nicotine seeking is mediated by glutamatergic plasticity. Proc Natl Acad Sci U S A 2013;110(22):9124-9129.

(20) Brown RM, Kupchik YM, Kalivas PW. The story of glutamate in drug addiction and of N-acetylcysteine as a potential pharmacotherapy. JAMA Psychiatry 2013;70(9):895-897.

(21) Gipson CD, Kupchik YM, Shen H, Reissner KJ, Thomas CA, Kalivas PW. Relapse induced by cues predicting cocaine depends on rapid, transient synaptic potentiation. Neuron 2013;77(5):867-872.

(22) Stefanik MT, Moussawi K, Kupchik YM, Smith KC, Miller RL, Huff ML, et al. Optogenetic inhibition of cocaine seeking in rats. Addict Biol 2013;18(1):50-53.

(23) Kupchik YM, Moussawi K, Tang X-, Wang X, Kalivas BC, Kolokithas R, et al. The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine. Biol Psychiatry 2012;71(11):978-986.

(24) Kupchik YM, Parnas H, Parnas I. A novel, extremely fast, feedback inhibition of glutamate release in the crayfish neuromuscular junction. Neuroscience 2011;172:44-54.

(25) Kupchik YM, Barchad-Avitzur O, Wess J, Ben-Chaim Y, Parnas I, Parnas H. A novel fast mechanism for GPCR-mediated signal transduction - Control of neurotransmitter release. J Cell Biol 2011;192(1):137-151.

(26) Kupchik YM, Rashkovan G, Ohana L, Keren-Raifman T, Dascal N, Parnas H, et al. Molecular mechanisms that control initiation and termination of physiological depolarization-evoked transmitter release. Proc Natl Acad Sci U S A 2008;105(11):4435-4440.