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The Faculty of Medicine - Medical Neurobiology: Treinin Millet


Last updated December 2021 - Medical Neurobiology

List of Publications

(1) Mizrachi T, Marsha O, Brusin K, Ben-David Y, Thakur GA, Vaknin-Dembinsky A, et al. Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107. J Neuroinflamm 2021;18(1).

(2) Mizrachi T, Vaknin-Dembinsky A, Brenner T, Treinin M. Neuroinflammation modulation via α7 nicotinic acetylcholine receptor and its chaperone, ric-3. Molecules 2021;26(20).

(3) Treinin M, Jin Y. Cholinergic transmission in C. elegans: Functions, diversity, and maturation of ACh-activated ion channels. J Neurochem 2021;158(6):1274-1291.

(4) Nourse JB, Harshefi G, Marom A, Karmi A, Cohen Ben-Ami H, Caldwell KA, et al. Conserved nicotine-activated neuroprotective pathways involve mitochondrial stress. iScience 2021;24(3).

(5) Ben-David Y, Kagan S, Cohen Ben-Ami H, Rostami J, Mizrahi T, Kulkarni AR, et al. RIC3, the cholinergic anti-inflammatory pathway, and neuroinflammation. Int Immunopharmacol 2020;83.

(6) Cohen E, Kumar R, Zinger T, Priel A, Treinin M. GTL-1, a calcium activated TRPM channel, enhances nociception. Front Pharmacol 2020;10.

(7) Papke RL, Stokes C, Damaj MI, Thakur GA, Manther K, Treinin M, et al. Persistent activation of α7 nicotinic ACh receptors associated with stable induction of different desensitized states. Br J Pharmacol 2018;175(11):1838-1854.

(8) Ben-David Y, Treinin M. Regulation of RIC-3 and of nAChR expression. Oncotarget 2017;8(4):5662-5663.

(9) Safdie G, Liewald JF, Kagan S, Battat E, Gottschalk A, Treinin M. RIC-3 phosphorylation enables dual regulation of excitation and inhibition of Caenorhabditis elegans muscle. Mol Biol Cell 2016;27(19):2994-3003.

(10) Ben-David Y, Mizrachi T, Kagan S, Krisher T, Cohen E, Brenner T, et al. RIC-3 expression and splicing regulate nAChR functional expression. Mol Brain 2016;9(1).

(11) Rabinowitch I, Laurent P, Zhao B, Walker D, Beets I, Schoofs L, et al. Neuropeptide-Driven Cross-Modal Plasticity following Sensory Loss in Caenorhabditis elegans. PloS Biol 2016;14(1).

(12) Stokes C, Treinin M, Papke RL. Looking below the surface of nicotinic acetylcholine receptors. Trends Pharmacol Sci 2015;36(8):514-523.

(13) Rabinowitch I, Chatzigeorgiou M, Zhao B, Treinin M, Schafer WR. Rewiring neural circuits by the insertion of ectopic electrical synapses in transgenic C. elegans. Nat Commun 2014;5.

(14) Cohen E, Chatzigeorgiou M, Husson SJ, Steuer-Costa W, Gottschalk A, Schafer WR, et al. Caenorhabditis elegans nicotinic acetylcholine receptors are required for nociception. Mol Cell Neurosci 2014;59:85-96.

(15) Sanders J, Nagy S, Fetterman G, Wright C, Treinin M, Biron D. The Caenorhabditis elegans interneuron ALA is (also) a high-threshold mechanosensor. BMC Neurosci 2013;14.

(16) Cohen E, Yemini E, Schafer W, Feitelson DG, Treinin M. Locomotion analysis identifies roles of mechanosensory neurons in governing locomotion dynamics of C. elegans. J Exp Biol 2012;215(20):3639-3648.

(17) Husson SJ, Costa WS, Wabnig S, Stirman JN, Watson JD, Spencer WC, et al. Optogenetic analysis of a nociceptor neuron and network reveals ion channels acting downstream of primary sensors. Curr Biol 2012;22(9):743-752.

(18) Hall DH, Treinin M. How does morphology relate to function in sensory arbors? Trends Neurosci 2011;34(9):443-451.

(19) Albeg A, Smith CJ, Chatzigeorgiou M, Feitelson DG, Hall DH, Schafer WR, et al. C. elegans multi-dendritic sensory neurons: Morphology and function. Mol Cell Neurosci 2011;46(1):308-317.

(20) Smith CJ, Watson JD, Spencer WC, O'Brien T, Cha B, Albeg A, et al. Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans. Dev Biol 2010;345(1):18-33.

(21) Chatzigeorgiou M, Yoo S, Watson JD, Lee W-, Spencer WC, Kindt KS, et al. Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors. Nat Neurosci 2010;13(7):861-868.

(22) Oren-Suissa M, Hall DH, Treinin M, Shemer G, Podbilewicz B. The fusogen EFF-I controls sculpting of mechanosensory dendrites. Science 2010;328(5983):1285-1288.

(23) Ben-Ami HC, Biala Y, Farah H, Elishevitz E, Battat E, Treinin M. Receptor and subunit specific interactions of RIC-3 with nicotinic acetylcholine receptors. Biochemistry 2009;48(51):12329-12336.

(24) Shteingauz A, Cohen E, Biala Y, Treinin M. The BTB-MATH protein BATH-42 interacts with RIC-3 to regulate maturation of nicotinic acetylcholine receptors. J Cell Sci 2009;122(6):807-812.

(25) Biala Y, Liewald JF, Ben-Ami HC, Gottschalk A, Treinin M. The conserved RIC-3 coiled-coil domain mediates receptor-specific interactions with nicotinic acetylcholine receptors. Mol Biol Cell 2009;20(5):1419-1427.

(26) Treinin M. RIC-3 and nicotinic acetylcholine receptors: Biogenesis, properties, and diversity. Biotechnol J 2008;3(12):1539-1547.

(27) Von Stetina SE, Treinin M, Miller III DM. The Motor Circuit. Int Rev Neurobiol 2005;69:125-167.

(28) Ben-Ami HC, Yassin L, Farah H, Michaeli A, Eshel M, Treinin M. RIC-3 affects properties and quantity of nicotinic acetylcholine receptors via a mechanism that does not require the coiled-coil domains. J Biol Chem 2005;280(30):28053-28060.

(29) Halevi S, Yassin L, Eshel M, Sala F, Sala S, Criado M, et al. Conservation within the RIC-3 gene family: Effectors of mammalian nicotinic acetylcholine receptor expression. J Biol Chem 2003;278(36):34411-34417.

(30) Treinin M, Shliar J, Jiang H, Powell-Coffman JA, Bromberg Z, Horowitz M. HIF-1 is required for heat acclimation in the nematode Caenorhabditis elegans. Physiol Genomics 2003;14:17-24.

(31) Yassin L, Samson AO, Halevi S, Eshel M, Treinin M. Mutations in the extracellular domain and in the membrane-spanning domains interfere with nicotinic acetylcholine receptor maturation. Biochemistry 2002;41(41):12329-12335.

(32) Feitelson DG, Treinin M. The blueprint for life. Computer 2002;35(7):34-40+9.

(33) Yassin L, Gillo B, Kahan T, Halevi S, Eshel M, Treinin M. Characterization of the DEG-3/DES-2 receptor: A nicotinic acetylcholine receptor that mutates to cause neuronal degeneration. Mol Cell Neurosci 2001;17(3):589-599.

(34) Liu J, Ben-Shahar TR, Riemer D, Treinin M, Spann P, Weber K, et al. Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes. Mol Biol Cell 2000;11(11):3937-3947.

(35) Khatchatouriants A, Lewis A, Rothman Z, Loew L, Treinin M. GFP is a selective non-linear optical sensor of electrophysiological processes in Caenorhabditis elegans. Biophys J 2000;79(5):2345-2352.

(36) Near-field optical and atomic force constraints for super-resolution 3D deconvolution in far-field optical microscopy. Proceedings of SPIE - The International Society for Optical Engineering; 2000.

(37) Lewis A, Khatchatouriants A, Treinin M, Chen Z, Peleg G, Friedman N, et al. Second-harmonic generation of biological interfaces: Probing the membrane protein bacteriorhodopsin and imaging membrane potential around GFP molecules at specific sites in neuronal cells of C. elegans. Chem Phys 1999;245(1-3):133-144.

(38) Treinin M, Gillo B, Liebman L, Chalfie M. Two functionally dependent acetylcholine subunits are encoded in a single Caenorhabditis elegans operon. Proc Natl Acad Sci U S A 1998;95(26):15492-15495.

(39) Treinin M, Chalfie M. A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans. Neuron 1995;14(4):871-877.

(40) Treinin M, Simchen G. Mitochondrial activity is required for the expression of IME1, a regulator of meiosis in yeast. Curr Genet 1993;23(3):223-227.

(41) Treinin M, Feitelson DG. Unequal cell division as a driving force during differentiation. J Theor Biol 1993;160(1):85-95.

(42) Matsuura A, Treinin M, Mitsuzawa H, Kassir Y, Uno I, Simchen G. The adenylate cyclase/protein kinase cascade regulates entry into meiosis in Saccharomyces cerevisiae through the gene IME1. EMBO J 1990;9(10):3225-3232.

(43) Treinin M, Laub O. Identification of a promoter element located upstream from the hepatitis B virus X gene. Mol Cell Biol 1987;7(1):545-548.