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The Faculty of Medicine - Immunology and Cancer Research: Drier Yotam


Last updated December 2021 -  Immunology and Cancer Research

List of Publications

(1) Anand P, Guillaumet-Adkins A, Dimitrova V, Yun H, Drier Y, Sotudeh N, et al. Single-cell RNA-seq reveals developmental plasticity with coexisting oncogenic states and immune evasion programs in ETP-ALL. Blood 2021;137(18):2463-2480.

(2) Johnstone SE, Reyes A, Qi Y, Adriaens C, Hegazi E, Pelka K, et al. Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer. Cell 2020;182(6):1474-1489.e23.

(3) Ben-Ami R, Klochendler A, Seidel M, Sido T, Gurel-Gurevich O, Yassour M, et al. Large-scale implementation of pooled RNA extraction and RT-PCR for SARS-CoV-2 detection. Clin Microbiol Infect 2020;26(9):1248-1253.

(4) Abascal F, Acosta R, Addleman NJ, Adrian J, Afzal V, Aken B, et al. Perspectives on ENCODE. Nature 2020;583(7818):693-698.

(5) Abascal F, Acosta R, Addleman NJ, Adrian J, Afzal V, Aken B, et al. Expanded encyclopaedias of DNA elements in the human and mouse genomes. Nature 2020;583(7818):699-710.

(6) Kato S, Weng QY, Insco ML, Chen KY, Muralidhar S, Pozniak J, et al. Gain-of-function genetic alterations of g9a drive oncogenesis. Cancer Discov 2020;10(7):980-997.

(7) Drier Y. Enhancer and superenhancer regulation and its disruption in cancer. Curr Opin Syst 2020;19:24-30.

(8) Flavahan WA, Drier Y, Johnstone SE, Hemming ML, Tarjan DR, Hegazi E, et al. Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs. Nature 2019;575(7781):229-233.

(9) Cejas P, Drier Y, Dreijerink KMA, Brosens LAA, Deshpande V, Epstein CB, et al. Publisher Correction: Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors (Nature Medicine, (2019), 25, 8, (1260-1265), 10.1038/s41591-019-0493-4). Nat Med 2019;25(10):1627.

(10) Raoof S, Mulford IJ, Frisco-Cabanos H, Nangia V, Timonina D, Labrot E, et al. Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer. Oncogene 2019;38(37):6399-6413.

(11) Cejas P, Drier Y, Dreijerink KMA, Brosens LAA, Deshpande V, Epstein CB, et al. Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors. Nat Med 2019;25(8):1264-1269.

(12) Song K-, Niederst MJ, Lochmann TL, Hata AN, Kitai H, Ham J, et al. Epithelial-to-mesenchymal transition antagonizes response to targeted therapies in lung cancer by suppressing BIM. Clin Cancer Res 2018;24(1):197-208.

(13) Shah N, Wang P, Wongvipat J, Karthaus WR, Abida W, Armenia J, et al. Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer. eLife 2017;6.

(14) Wang X, Lee RS, Alver BH, Haswell JR, Wang S, Mieczkowski J, et al. SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation. Nat Genet 2017;49(2):289-295.

(15) Lohr JG, Kim S, Gould J, Knoechel B, Drier Y, Cotton MJ, et al. Genetic interrogation of circulating multiple myeloma cells at single-cell resolution. Sci Transl Med 2016;8(363).

(16) Drier Y, Cotton MJ, Williamson KE, Gillespie SM, Ryan RJH, Kluk MJ, et al. An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma. Nat Genet 2016;48(3):265-272.

(17) Flavahan WA, Drier Y, Liau BB, Gillespie SM, Venteicher AS, Stemmer-Rachamimov AO, et al. Insulator dysfunction and oncogene activation in IDH mutant gliomas. Nature 2016;529(7584):110-114.

(18) van Galen P, Viny AD, Ram O, Ryan RJH, Cotton MJ, Donohue L, et al. A Multiplexed System for Quantitative Comparisons of Chromatin Landscapes. Mol Cell 2016;61(1):170-180.

(19) Ryan RJH, Drier Y, Whitton H, Cotton MJ, Kaur J, Issner R, et al. Detection of enhancer-associated rearrangements reveals mechanisms of oncogene dysregulation in B-cell lymphoma. Cancer Discov 2015;5(10):1058-1071.

(20) Gagliani N, Amezcua Vesely MC, Iseppon A, Brockmann L, Xu H, Palm NW, et al. TH17 cells transdifferentiate into regulatory T cells uring resolution of inflammation. Nature 2015;523(7559):221-225.

(21) Lawrence MS, Stojanov P, Polak P, Kryukov GV, Cibulskis K, Sivachenko A, et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature 2013;499(7457):214-218.

(22) Baca SC, Prandi D, Lawrence MS, Mosquera JM, Romanel A, Drier Y, et al. Punctuated evolution of prostate cancer genomes. Cell 2013;153(3):666-677.

(23) Drier Y, Sheffer M, Domany E. Pathway-based personalized analysis of cancer. Proc Natl Acad Sci U S A 2013;110(16):6388-6393.

(24) Drier Y, Lawrence MS, Carter SL, Stewart C, Gabriel SB, Lander ES, et al. Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability. Genome Res 2013;23(2):228-235.

(25) Williams LJS, Tabbaa DG, Li N, Berlin AM, Shea TP, MacCallum I, et al. Paired-end sequencing of Fosmid libraries by Illumina. Genome Res 2012;22(11):2241-2249.

(26) Berger MF, Hodis E, Heffernan TP, Deribe YL, Lawrence MS, Protopopov A, et al. Melanoma genome sequencing reveals frequent PREX2 mutations. Nature 2012;485(7399):502-506.

(27) Bass AJ, Lawrence MS, Brace LE, Ramos AH, Drier Y, Cibulskis K, et al. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nat Genet 2011;43(10):964-970.

(28) Zwang Y, Sas-Chen A, Drier Y, Shay T, Avraham R, Lauriola M, et al. Two Phases of Mitogenic Signaling Unveil Roles for p53 and EGR1 in Elimination of Inconsistent Growth Signals. Mol Cell 2011;42(4):524-535.

(29) Chapman MA, Lawrence MS, Keats JJ, Cibulskis K, Sougnez C, Schinzel AC, et al. Initial genome sequencing and analysis of multiple myeloma. Nature 2011;471(7339):467-472.

(30) Drier Y, Domany E. Do two machine-learning based prognostic signatures for breast cancer capture the same biological processes? PLoS ONE 2011;6(3).

(31) Berger MF, Lawrence MS, Demichelis F, Drier Y, Cibulskis K, Sivachenko AY, et al. The genomic complexity of primary human prostate cancer. Nature 2011;470(7333):214-220.

(32) Drier Y, Linial N. Minors in lifts of graphs. Random Struct Algorithms 2006;29(2):208-225.