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The Faculty of Medicine - Immunology and Cancer Research: Parnas Oren

Researchers

Last updated December 2021 -  Immunology and Cancer Research

List of Publications

(1) Haddad CO, Kalt I, Shovman Y, Xia L, Schlesinger Y, Sarid R, et al. Targeting the Kaposi’s sarcoma-associated herpesvirus genome with the CRISPR-Cas9 platform in latently infected cells. Virol J 2021;18(1).

(2) Kolodkin-Gal D, Roitman L, Ovadya Y, Azazmeh N, Assouline B, Schlesinger Y, et al. Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions. Gut 2021.

(3) Schlesinger Y, Yosefov-Levi O, Kolodkin-Gal D, Granit RZ, Peters L, Kalifa R, et al. Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity. Nat Commun 2020;11(1).

(4) Feregrino C, Sacher F, Parnas O, Tschopp P. A single-cell transcriptomic atlas of the developing chicken limb. BMC Genomics 2019;20(1).

(5) Shemesh K, Sebesta M, Pacesa M, Sau S, Bronstein A, Parnas O, et al. A structure-function analysis of the yeast Elg1 protein reveals the importance of PCNA unloading in genome stability maintenance. Nucleic Acids Res 2017;45(6):3189-3203.

(6) Dixit A, Parnas O, Li B, Chen J, Fulco CP, Jerby-Arnon L, et al. Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens. Cell 2016;167(7):1853-1866.e17.

(7) Adamson B, Norman TM, Jost M, Cho MY, Nuñez JK, Chen Y, et al. A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response. Cell 2016;167(7):1867-1882.e21.

(8) Lee J, Moraes-Vieira PM, Castoldi A, Aryal P, Yee EU, Vickers C, et al. Branched fatty acid esters of hydroxy fatty acids (FAHFAs) protect against colitis by regulating gut innate and adaptive immune responses. J Biol Chem 2016;291(42):22207-22217.

(9) Parnas O, Jovanovic M, Eisenhaure TM, Herbst RH, Dixit A, Ye CJ, et al. A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks. Cell 2015;162(3):675-686.

(10) Gazy I, Liefshitz B, Parnas O, Kupiec M. Elg1, a central player in genome stability. Mutat Res Rev Mutat Res 2015;763:267-279.

(11) Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, et al. CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell 2014;159(2):440-455.

(12) Parnas O, Corcoran DL, Cullen BR. Analysis of the mRNA targetome of microRNAs expressed by Marek's disease virus. mBio 2014;5(1).

(13) Gazy I, Liefshitz B, Bronstein A, Parnas O, Atias N, Sharan R, et al. A genetic screen for high copy number suppressors of the synthetic lethality between elg1Δ and srs2Δ in yeast. G3 Genes Genome Genet 2013;3(5):917-926.

(14) Parnas O, Amishay R, Liefshitz B, Zipin-Roitman A, Kupiec M. Elg1, the major subunit of an alternative RFC complex, interacts with SUMO-processing proteins. Cell Cycle 2011;10(17):2894-2903.

(15) Parnas O, Kupiec M. Establishment of sister chromatid cohesion: The role of the clamp loaders. Cell Cycle 2010;9(23):4615.

(16) Parnas O, Zipin-Roitman A, Pfander B, Liefshitz B, Mazor Y, Ben-Aroya S, et al. Elg1, an alternative subunit of the RFC clamp loader, preferentially interacts with SUMOylated PCNA. EMBO J 2010;29(15):2611-2622.

(17) Parnas O, Zipin-Roitman A, Mazor Y, Liefshitz B, Ben-Aroya S, Kupiec M. The Elg1 clamp loader plays a role in sister chromatid cohesion. PLoS ONE 2009;4(5).