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The Faculty of Medicine - Immunology and Cancer Research: Pikarsky Eli


Last updated December 2021 -  Immunology and Cancer Research

List of Publications

(1) Venkatachalam A, Pikarsky E, Ben-Neriah Y. Putative homeostatic role of cancer driver mutations. Trends Cell Biol 2022;32(1):8-17.

(2) Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S, et al. Hepatocellular carcinoma. Nat Rev Disease Prim 2021;7(1).

(3) Zhang P, Fischer A, Ouyang Y, Wang J, Sohn YS, Nechushtai R, et al. Aptamer-modified DNA tetrahedra-gated metal-organic framework nanoparticle carriers for enhanced chemotherapy or photodynamic therapy. Chem Sci 2021;12(43):14473-14483.

(4) Alfi O, Yakirevitch A, Wald O, Wandel O, Izhar U, Oiknine-Djian E, et al. Human nasal and lung tissues infected ex vivo with SARS-CoV-2 provide insights into differential tissue-specific and virus-specific innate immune responses in the upper and lower respiratory tract. J Virol 2021;95(14).

(5) Zhang P, Ouyang Y, Sohn YS, Nechushtai R, Pikarsky E, Fan C, et al. PH- And miRNA-Responsive DNA-Tetrahedra/Metal-Organic Framework Conjugates: Functional Sense-and-Treat Carriers. ACS Nano 2021;15(4):6645-6657.

(6) Llovet JM, Castet F, Heikenwalder M, Maini MK, Mazzaferro V, Pinato DJ, et al. Immunotherapies for hepatocellular carcinoma. Nat Rev Clin Oncol 2021.

(7) Kolodkin-Gal D, Roitman L, Ovadya Y, Azazmeh N, Assouline B, Schlesinger Y, et al. Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions. Gut 2021.

(8) Massalha H, Bahar Halpern K, Abu-Gazala S, Jana T, Massasa EE, Moor AE, et al. A single cell atlas of the human liver tumor microenvironment. Mol Syst Biol 2020;16(12).

(9) Ben-Hamo R, Jacob Berger A, Gavert N, Miller M, Pines G, Oren R, et al. Predicting and affecting response to cancer therapy based on pathway-level biomarkers. Nat Commun 2020;11(1).

(10) Azazmeh N, Assouline B, Winter E, Ruppo S, Nevo Y, Maly A, et al. Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation. Nat Commun 2020;11(1).

(11) Kravtsova-Ivantsiv Y, Goldhirsh G, Ivantsiv A, Itzhak OB, Kwon YT, Pikarsky E, et al. Excess of the NF-κB p50 subunit generated by the ubiquitin ligase KPC1 suppresses tumors via PD-L1-and chemokines-mediated mechanisms. Proc Natl Acad Sci U S A 2020;117(47):29823-29831.

(12) Kadosh E, Snir-Alkalay I, Venkatachalam A, May S, Lasry A, Elyada E, et al. The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic. Nature 2020;586(7827):133-138.

(13) Romaniello D, Marrocco I, Nataraj NB, Ferrer I, Drago-Garcia D, Vaknin I, et al. Targeting her3, a catalytically defective receptor tyrosine kinase, prevents resistance of lung cancer to a third-generation egfr kinase inhibitor. Cancers 2020;12(9):1-20.

(14) Golubicki M, Bonjoch L, Acuña-Ochoa JG, Díaz-Gay M, Muñoz J, Cuatrecasas M, et al. Germline biallelic Mcm8 variants are associated with early-onset Lynch-like syndrome. JCI Insight 2020;5(18).

(15) Landolina N, Zaffran I, Smiljkovic D, Serrano-Candelas E, Schmiedel D, Friedman S, et al. Activation of Siglec-7 results in inhibition of in vitro and in vivo growth of human mast cell leukemia cells. Pharmacol Res 2020;158.

(16) Salaymeh Y, Farago M, Sebban S, Shalom B, Pikarsky E, Katzav S. Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice. Life Sci Alliance 2020;3(5).

(17) Ansari I, Raddatz G, Gutekunst J, Ridnik M, Cohen D, Abu-Remaileh M, et al. The microbiota programs DNA methylation to control intestinal homeostasis and inflammation. Nat Microbiol 2020;5(4):610-619.

(18) Cinnamon E, Pikarsky E. Are we ready for targeted therapy combinations in HCC? Gut 2020;69(4):613-614.

(19) Wolf Y, Bartok O, Patkar S, Eli GB, Cohen S, Litchfield K, et al. UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma. Cell 2019;179(1):219-235.e21.

(20) Rosenfeld YB-, Krumbein M, Yeffet A, Schiffmann N, Mishalian I, Pikarsky E, et al. VICKZ1 enhances tumor progression and metastasis in lung adenocarcinomas in mice. Oncogene 2019;38(21):4169-4181.

(21) Malakar P, Stein I, Saragovi A, Winkler R, Stern-Ginossar N, Berger M, et al. Long noncoding RNA MALAT1 regulates cancer glucose metabolism by enhancing mTOR-Mediated Translation of TCF7L2. Cancer Res 2019;79(10):2480-2493.

(22) Roy S, Hooiveld GJ, Seehawer M, Caruso S, Heinzmann F, Schneider AT, et al. microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis. Gastroenterology 2018;155(6):1951-1966.e26.

(23) Abu-Remaileh M, Khalaileh A, Pikarsky E, Aqeilan RI. Correction to: WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia (Cell Death & Disease, (2018), 9, 5, (511), 10.1038/s41419-018-0510-4). Cell Death Dis 2018;9(12).

(24) Reizel Y, Sabag O, Skversky Y, Spiro A, Steinberg B, Bernstein D, et al. Postnatal DNA demethylation and its role in tissue maturation. Nat Commun 2018;9(1).

(25) Pikarsky E. Neighbourhood deaths cause a switch in cancer subtype. Nature 2018;562(7725):45-46.

(26) Shalom B, Farago M, Pikarsky E, Katzav S. Vav1 mutations identified in human cancers give rise to different oncogenic phenotypes. Oncogenesis 2018;7(10).

(27) Minzel W, Venkatachalam A, Fink A, Hung E, Brachya G, Burstain I, et al. Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell 2018;175(1):171-185.e25.

(28) Hanin G, Yayon N, Tzur Y, Haviv R, Bennett ER, Udi S, et al. miRNA-132 induces hepatic steatosis and hyperlipidaemia by synergistic multitarget suppression. Gut 2018;67(6):1124-1134.

(29) Abu-Remaileh M, Khalaileh A, Pikarsky E, Aqeilan RI. WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia article. Cell Death Dis 2018;9(5).

(30) Ringelhan M, Pfister D, O'Connor T, Pikarsky E, Heikenwalder M. The immunology of hepatocellular carcinoma review-article. Nat Immunol 2018;19(3):222-232.

(31) Grinshpun A, Gavert N, Granit RZ, Masuri H, Ben-Porath I, Breuer S, et al. Ev vivo organ culture as potential prioritization tool for breast cancer targeted therapy. Cancer Biol Ther 2018;19(8):645-648.

(32) Heikenwälder M, Pikarsky E. Learning the Roles of the Hepatic Adaptive Immune System in Hepatocellular Carcinoma--Nature's Guide for Successful Cancer Immunotherapy. Semin Liver Dis 2017;37(3):210-218.

(33) Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, et al. Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS. Cancer Cell 2017;31(6):771-789.e6.

(34) Zick A, Peretz T, Lotem M, Hubert A, Katz D, Temper M, et al. Treatment inferred from mutations identified using massive parallel sequencing leads to clinical benefit in some heavily pretreated cancer patients. Medicine 2017;96(20).

(35) Tarcic O, Granit RZ, Pateras IS, Masury H, Maly B, Zwang Y, et al. RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer. Cell Death Differ 2017;24(4):694-704.

(36) Etzioni A, Ciechanover A, Pikarsky E. Immune defects caused by mutations in the ubiquitin system. J Allergy Clin Immunol 2017;139(3):743-753.

(37) Malakar P, Shilo A, Mogilevsky A, Stein I, Pikarsky E, Nevo Y, et al. Long noncoding RNA MALAT1 promotes hepatocellular carcinoma development by SRSF1 upregulation and mTOR activation. Cancer Res 2017;77(5):1155-1167.

(38) Roichman A, Kanfi Y, Glazz R, Naiman S, Amit U, Landa N, et al. SIRT6 overexpression improves various aspects of mouse healthspan. J Gerontol Ser A Biol Sci Med Sci 2017;72(5):603-615.

(39) Pikarsky E, Heikenwalder M. Focal and Local: Ectopic Lymphoid Structures and Aggregates of Myeloid and Other Immune Cells in Liver. Gastroenterology 2016;151(5):780-783.

(40) Li D, Fu J, Du M, Zhang H, Li L, Cen J, et al. Hepatocellular carcinoma repression by TNFα-mediated synergistic lethal effect of mitosis defect-induced senescence and cell death sensitization. Hepatology 2016;64(4):1105-1120.

(41) Darash-Yahana M, Pozniak Y, Lu M, Sohn Y-, Karmi O, Tamir S, et al. Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters. Proc Natl Acad Sci U S A 2016;113(39):10890-10895.

(42) Abed J, Emgård JEM, Zamir G, Faroja M, Almogy G, Grenov A, et al. Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc. Cell Host and Microbe 2016;20(2):215-225.

(43) Aran D, Lasry A, Zinger A, Biton M, Pikarsky E, Hellman A, et al. Widespread parainflammation in human cancer. Genome Biol 2016;17(1).

(44) Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M, et al. Hepatocellular carcinoma. Nat Rev Disease Prim 2016;2.

(45) Katlinskaya YV, Katlinski KV, Lasri A, Li N, Beiting DP, Durham AC, et al. Type I interferons control proliferation and function of the intestinal epithelium. Mol Cell Biol 2016;36(7):1124-1135.

(46) Samarin J, Laketa V, Malz M, Roessler S, Stein I, Horwitz E, et al. PI3K/AKT/mTOR-dependent stabilization of oncogenic far-upstream element binding proteins in hepatocellular carcinoma cells. Hepatology 2016;63(3):813-826.

(47) Tarcic O, Pateras IS, Cooks T, Shema E, Kanterman J, Ashkenazi H, et al. RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer. Cell Rep 2016;14(6):1462-1476.

(48) Holt SH, Darash-Yahana M, Sohn YS, Song L, Karmi O, Tamir S, et al. Activation of apoptosis in NAF-1-deficient human epithelial breast cancer cells. J Cell Sci 2016;129(1):155-165.

(49) Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, et al. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol 2015;16(12):1235-1244.

(50) Hefetz-Sela S, Stein I, Pikarsky E. Restoring inflammatory balance as a potential preventive strategy for inflammation induced cancer. OncoImmunology 2015;4(11).

(51) Lazar CH, Kimchi A, Namburi P, Mutsuddi M, Zelinger L, Beryozkin A, et al. Nonsyndromic Early-Onset Cone-Rod Dystrophy and Limb-Girdle Muscular Dystrophy in a Consanguineous Israeli Family are Caused by Two Independent yet Linked Mutations in ALMS1 and DYSF. Hum Mutat 2015;36(9):836-841.

(52) Michaeli TF, Laufer N, Sagiv JY, Dreazen A, Granot Z, Pikarsky E, et al. The rejuvenating effect of pregnancy on muscle regeneration. Aging Cell 2015;14(4):698-700.

(53) Pribluda A, Elyada E, Wiener Z, Hamza H, Goldstein RE, Biton M, et al. Erratum to A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism [Cancer Cell 24, (2013) 242-256]. Cancer Cell 2015;27(6):877-878.

(54) Abu-Remaileh M, Bender S, Raddatz G, Ansari I, Cohen D, Gutekunst J, et al. Chronic inflammation induces a novel epigenetic program that is conserved in intestinal adenomas and in colorectal cancer. Cancer Res 2015;75(10):2120-2130.

(55) Gilad R, Meir K, Stein I, German L, Pikarsky E, Mabjeesh NJ. High SEPT9-i1 protein expression is associated with high-grade prostate cancers. PLoS ONE 2015;10(4).

(56) Kravtsova-Ivantsiv Y, Shomer I, Cohen-Kaplan V, Snijder B, Superti-Furga G, Gonen H, et al. KPC1-mediated ubiquitination and proteasomal processing of nf-κb1 p105 to p50 restricts tumor growth. Cell 2015;161(2):333-347.

(57) Horwitz E, Stein I, Ben-Neriah Y, Pikarsky E. Animal model studies indicate a candidate biomarker for sorafenib treatment of hepatocellular carcinoma. Mol Cell Oncol 2015;2(1).

(58) Hefetz-Sela S, Stein I, Klieger Y, Porat R, Sade-Feldman M, Zreik F, et al. Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation. Proc Natl Acad Sci U S A 2014;111(49):17582-17587.

(59) Gluschnaider U, Hertz R, Ohayon S, Smeir E, Smets M, Pikarsky E, et al. Long-chain fatty acid analogues suppress breast tumorigenesis and progression. Cancer Res 2014;74(23):6991-7002.

(60) Kanarek N, Grivennikov SI, Leshets M, Lasry A, Alkalay I, Horwitz E, et al. Critical role for IL-1β in DNA damageinduced mucositis. Proc Natl Acad Sci U S A 2014;111(6):E702-E711.

(61) Yanger K, Knigin D, Zong Y, Maggs L, Gu G, Akiyama H, et al. Adult hepatocytes are generated by self-duplication rather than stem cell differentiation. Cell Stem Cell 2014;15(3):340-349.

(62) Sebban S, Farago M, Rabinovich S, Lazer G, Idelchuck Y, Ilan L, et al. Vav1 promotes lung cancer growth by instigating tumor-microenvironment cross-talk via growth factor secretion. Oncotarget 2014;5(19):9214-9226.

(63) Horwitz E, Stein I, Andreozzi M, Nemeth J, Shoham A, Pappo O, et al. Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to Sorafenib treatment. Cancer Discov 2014;4(6):730-743.

(64) Shilo A, Hur VB, Denichenko P, Stein I, Pikarsky E, Rauch J, et al. Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development. RNA 2014;20(4):505-515.

(65) Barashi N, Weiss ID, Wald O, Wald H, Beider K, Abraham M, et al. Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice. Hepatology 2013;58(3):1021-1030.

(66) Cooks T, Pateras I, Tarcic O, Solomon H, Schetter A, Wilder S, et al. Mutant p53 Prolongs NF-kB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cancer Cell 2013;24(2):272.

(67) Pribluda A, Elyada E, Wiener Z, Hamza H, Goldstein R, Biton M, et al. A Senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. Cancer Cell 2013;24(2):242-256.

(68) Pusterla T, Nèmeth J, Stein I, Wiechert L, Knigin D, Marhenke S, et al. Receptor for advanced glycation endproducts (RAGE) is a key regulator of oval cell activation and inflammation-associated liver carcinogenesis in mice. Hepatology 2013;58(1):363-373.

(69) Cooks T, Pateras I, Tarcic O, Solomon H, Schetter A, Wilder S, et al. Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer. Cancer Cell 2013;23(5):634-646.

(70) Sebban S, Farago M, Gashai D, Ilan L, Pikarsky E, Ben-Porath I, et al. Vav1 Fine Tunes p53 Control of Apoptosis versus Proliferation in Breast Cancer. PLoS ONE 2013;8(1).

(71) Perets R, Kaplan T, Stein I, Hidas G, Tayeb S, Avraham E, et al. Genome-Wide Analysis of Androgen Receptor Targets Reveals COUP-TF1 as a Novel Player in Human Prostate Cancer. PLoS ONE 2012;7(10).

(72) Finkin S, Pikarsky E. NF-κB in liver cancer: The plot thickens. Curr Top Microbiol Immunol 2011;349:185-196.

(73) Israeli E, Yakunin E, Zarbiv Y, Hacohen-Solovich A, Kisos H, Loeb V, et al. α-Synuclein expression selectively affects tumorigenesis in mice modeling Parkinson's disease. PLoS ONE 2011;6(5).

(74) Beider K, Begin M, Abraham M, Wald H, Weiss ID, Wald O, et al. CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth. Exp Hematol 2011;39(3):282-292.

(75) Biton M, Levin A, Slyper M, Alkalay I, Horwitz E, Mor H, et al. Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk. Nat Immunol 2011;12(3):239-246.

(76) Elyada E, Pribluda A, Goldstein RE, Morgenstern Y, Brachya G, Cojocaru G, et al. CKIα ablation highlights a critical role for p53 in invasiveness control. Nature 2011;470(7334):409-413.

(77) Goldberg Y, Porat R, Kedar I, Shochat C, Galinsky D, Hamburger T, et al. An Ashkenazi founder mutation in the MSH6 gene leading to HNPCC. Fam Cancer 2010;9(2):141-150.

(78) Demaria S, Pikarsky E, Karin M, Coussens LM, Chen Y-, El-Omar EM, et al. Cancer and inflammation: Promise for biologic therapy. J Immunother 2010;33(4):335-351.

(79) Zaaroor-Regev D, De Bie P, Scheffner M, Noy T, Shemer R, Heled M, et al. Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome. Proc Natl Acad Sci U S A 2010;107(15):6788-6793.

(80) Resnick I, Stepensky P, Elkin G, Barkatz C, Gurevich O, Prigozhina T, et al. MSC for the improvement of hematopoietic engraftment. Bone Marrow Transplant 2010;45(3):605-606.

(81) Gielchinsky Y, Laufer N, Weitman E, Abramovitch R, Granot Z, Bergman Y, et al. Pregnancy restores the regenerative capacity of the aged liver via activation of an mTORC1-controlled hyperplasia/hypertrophy switch. Genes Dev 2010;24(6):543-548.

(82) Bitton-Worms K, Pikarsky E, Aronheim A. The AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in mice. Mol Cancer 2010;9.

(83) Kanarek N, Horwitz E, Mayan I, Leshets M, Cojocaru G, Davis M, et al. Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCFβ-TrCP by single substrate depletion. Genes Dev 2010;24(5):470-477.

(84) Gluschnaider U, Hidas G, Cojocaru G, Yutkin V, Ben-Neriah Y, Pikarsky E. β-TrCP inhibition reduces prostate cancer cell growth via upregulation of the aryl hydrocarbon receptor. PLoS ONE 2010;5(2).

(85) Barash H, Gross ER, Edrei Y, Ella E, Israel A, Cohen I, et al. Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks. Proc Natl Acad Sci U S A 2010;107(5):2207-2212.

(86) Németh J, Stein I, Haag D, Riehl A, Longerich T, Horwitz E, et al. S100A8 and S100A9 are novel nuclear factor kappa b target genes during malignant progression of murine and human liver carcinogenesis. Hepatology 2009;50(4):1251-1262.

(87) Lazer G, Idelchuk Y, Schapira V, Pikarsky E, Katzav S. The haematopoietic specific signal transducer Vav1 is aberrantly expressed in lung cancer and plays a role in tumourigenesis. J Pathol 2009;219(1):25-34.

(88) Toledano H, Goldberg Y, Kedar-Barnes I, Baris H, Porat RM, Shochat C, et al. Homozygosity of MSH2 c.1906G→C germline mutation is associated with childhood colon cancer, astrocytoma and signs of Neurofibromatosis type i. Fam Cancer 2009;8(3):187-194.

(89) Darash-Yahana M, Gillespie JW, Hewitt SM, Chen Y-K, Maeda S, Stein I, et al. The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers. PLoS ONE 2009;4(8).

(90) Kolodkin-Gal D, Edden Y, Hartshtark Z, Ilan L, Khalaileh A, Pikarsky AJ, et al. Herpes simplex virus delivery to orthotopic rectal carcinoma results in an efficient and selective antitumor effect. Gene Ther 2009;16(7):905-915.

(91) Beider K, Abraham M, Begin M, Wald H, Weiss ID, Wald O, et al. Interaction between CXCR4 and CCL20 pathways regulates tumor growth. PLoS ONE 2009;4(4).

(92) Nechushtan H, Hamburger T, Mendelson S, Kadouri L, Sharon N, Pikarsky E, et al. Effects of the single nucleotide polymorphism at MDM2 309 on breast cancer patients with/without BRCA1/2 mutations. BMC Cancer 2009;9.

(93) Meyuhas R, Pikarsky E, Tavor E, Klar A, Abramovitch R, Hochman J, et al. A key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1(CYR61) in tumor cells. Mol Cancer Res 2008;6(9):1397-1409.

(94) Vainer GW, Pikarsky E, Ben-Neriah Y. Contradictory functions of NF-κB in liver physiology and cancer. Cancer Lett 2008;267(2):182-188.

(95) Vainer G, Vainer-Mossel E, Pikarsky A, Shenoy SM, Oberman F, Yeffet A, et al. A role for VICKZ proteins in the progression of colorectal carcinomas: Regulating lamellipodia formation. J Pathol 2008;215(4):445-456.

(96) Lerner I, Baraz L, Pikarsky E, Meirovitz A, Edovitsky E, Peretz T, et al. Function of heparanase in prostate tumorigenesis: Potential for therapy. Clin Cancer Res 2008;14(3):668-676.

(97) Vaknin I, Blinder L, Wang L, Gazit R, Shapira E, Genina O, et al. A common pathway mediated through Toll-like receptors leads to T- and natural killer-cell immunosuppression. Blood 2008;111(3):1437-1447.

(98) Kolodkin-Gal D, Zamir G, Edden Y, Pikarsky E, Pikarsky A, Haim H, et al. Herpes simplex virus type 1 preferentially targets human colon carcinoma: Role of extracellular matrix. J Virol 2008;82(2):999-1010.

(99) Yutkin V, Pode D, Pikarsky E, Mandelboim O. The Expression Level of Ligands for Natural Killer Cell Receptors Predicts Response to Bacillus Calmette-Guerin Therapy: A Pilot Study. J Urol 2007;178(6):2660-2664.

(100) Cohen I, Maly B, Simon I, Meirovitz A, Pikarsky E, Zcharia E, et al. Tamoxifen induces heparanase expression in estrogen receptor - Positive breast cancer. Clin Cancer Res 2007;13(14):4069-4077.

(101) Bala M, Lebenthal A, Pikarsky E, Faroja M, Rivkind AI, Mintz Y. Intestinal stenosis causing small bowel obstruction after nonoperative management of blunt abdominal trauma. J Trauma Inj Infect Crit Care 2007;62(6):1511-1513.

(102) De Marzo AM, Platz EA, Epstein JI, Ali T, Billis A, Chan TY, et al. Erratum: A working group classification of focal prostate atrophy lesions (American Journal of Surgical Pathology (2006) 30, (1281-1291)). Am J Surg Pathol 2007;31(4):652.

(103) Natkunam Y, Vainer G, Chen J, Zhao S, Marinelli RJ, Hammer AS, et al. Expression of the RNA-binding protein VICKZ in normal hematopoietic tissues and neoplasms. Haematologica 2007;92(2):176-183+II.

(104) De Marzo AM, Platz EA, Epstein JI, Ali T, Billis A, Chan TY, et al. Erratum: A working group classification of focal prostate atrophy lesions (American Journal of Surgical Pathology (2006) 30 (1281-1291)). Am J Surg Pathol 2006;30(11):1489.

(105) Tshori S, Gilon D, Beeri R, Nechushtan H, Kaluzhny D, Pikarsky E, et al. Transcription factor MITF regulates cardiac growth and hypertrophy. J Clin Invest 2006;116(10):2673-2681.

(106) Ezernitchi AV, Vaknin I, Cohen-Daniel L, Levy O, Manaster E, Halabi A, et al. TCR ζ down-regulation under chronic inflammation is mediated by myeloid suppressor cells differentially distributed between various lymphatic organs. J Immunol 2006;177(7):4763-4772.

(107) De Marzo AM, Platz EA, Epstein JI, Ali T, Billis A, Chan TY, et al. A working group classification of focal prostate atrophy lesions. Am J Surg Pathol 2006;30(10):1281-1291.

(108) Pikarsky E, Ben-Neriah Y. NF-κB inhibition: A double-edged sword in cancer? Eur J Cancer 2006;42(6):779-784.

(109) Banin E, Obolensky A, Idelson M, Hemo I, Reinhardtz E, Pikarsky E, et al. Retinal incorporation and differentiation of neural precursors derived from human embryonic stem cells. Stem Cells 2006;24(2):246-257.

(110) Daum H, Sagi M, Pikarsky E, Pruss D, Hamburger T, Peretz T. Prophylactic oophorectomy among carriers of BRCA1/2 mutations - Demographic and pathologic data. Harefuah 2006;145(1 SPEC. ISS.):13-17.

(111) Kochupurakkal BS, Harari D, Di-Segni A, Maik-Rachline G, Lyass L, Gur G, et al. Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity. J Biol Chem 2005;280(9):8503-8512.

(112) Nickoloff BJ, Ben-Neriah Y, Pikarsky E. Inflammation and cancer: Is the link as simple as we think? J Invest Dermatol 2005;124(6):x-xiv.

(113) Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, et al. NF-κB functions as a tumour promoter in inflammation-associated cancer. Nature 2004;431(7007):461-466.

(114) Pikarsky E, Ronen A, Abramowitz J, Levavi-Sivan B, Hutoran M, Shapira Y, et al. Pathogenesis of acute viral disease induced in fish by carp interstitial nephritis and gill necrosis virus. J Virol 2004;78(17):9544-9551.

(115) Darash-Yahana M, Pikarsky E, Abramovitch R, Zeira E, Pal B, Karplus R, et al. Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis. FASEB J 2004;18(11):1240-1242.

(116) Goldenberg-Furmanov M, Stein I, Pikarsky E, Rubin H, Kasem S, Wygoda M, et al. Lyn Is a Target Gene for Prostate Cancer: Sequence-Based Inhibition Induces Regression of Human Tumor Xenografts. Cancer Res 2004;64(3):1058-1066.

(117) Hornstein I, Pikarsky E, Groysman M, Amir G, Peylan-Ramu N, Katzav S. The haematopoietic specific signal transducer Vav1 is expressed in a subset of human neuroblastomas. J Pathol 2003;199(4):526-533.

(118) Banin E, Obolensky A, Piontek E, Falk H, Pikarsky E, Pe'er J, et al. Gene delivery by viral vectors in primary cultures of lacrimal gland tissue. Invest Ophthalmol Vis Sci 2003;44(4):1529-1533.

(119) Gidekel S, Pizov G, Bergman Y, Pikarsky E. Oct-3/4 is a dose-dependent oncogenic fate determinant. Cancer Cell 2003;4(5):361-370.

(120) Lavon I, Pikarsky E, Gutkovich E, Goldberg I, Bar J, Oren M, et al. Nuclear factor-κB protects the liver against genotoxic stress and functions independently of p53. Cancer Res 2003;63(1):25-30.

(121) Pikarsky E, Maly B, Maly A. Ceroid granuloma of the uterine cervix. Int J Gynecol Pathol 2002;21(2):191-193.

(122) Nir-Paz R, Ben-Chetrit E, Pikarsky E, Hassin D, Hasin Y, Chajek-Shaul T. Unusual presentation of familial Mediterranean fever: Role of genetic diagnosis. Ann Rheum Dis 2000;59(10):836-838.

(123) Diaz-Cano SJ, Funke I, Schraut W, Pikarsky E, Peretz T, Braun S, et al. Bone marrow metastases in breast cancer [1] (multiple letters). New Engl J Med 2000;343(8):577-578.

(124) Ben-Shushan E, Sharir H, Pikarsky E, Bergman Y. A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells. Mol Cell Biol 1995;15(2):1034-1048.

(125) Pikarsky E, Sharir H, Ben-Shushan E, Bergman Y. Retinoic acid represses Oct-3/4 gene expression through several retinoic acid-responsive elements located in the promoter-enhancer region. Mol Cell Biol 1994;14(2):1026-1038.

(126) Ben-Shushan E, Pikarsky E, Klar A, Bergman Y. Extinction of Oct-3/4 gene expression in embryonal carcinoma x fibroblast somatic cell hybrids is accompanied by changes in the methylation status, chromatin structure, and transcriptional activity of the Oct-3/4 upstream region. Mol Cell Biol 1993;13(2):891-901.

(127) Michowiz SD, Melamed E, Pikarsky E, Rappaport ZH. Effect of ischemia induced by middle cerebral artery occlusion on superoxide dismutase activity in rat brain. Stroke 1990;21(11):1613-1617.

(128) Melamed E, Soffer D, Rosenthal J, Pikarsky E, Reches A. Effect of intrastriatal and intranigral administration of synthetic neuromelanin on the dopaminergic neurotoxicity of MPTP in rodents. Neurosci Lett 1987;83(1-2):41-46.

(129) Pikarsky E, Melamed E, Rosenthal J, Uzzan A, Michowiz SD. The neurotoxin MPTP does not affect striatal superoxide dismutase activity in mice. Neurosci Lett 1987;82(3):327-331.

(130) Melamed E, Martinovits G, Pikarsky E, Rosenthal J, Uzzan A. Diphenylhydantoin and phenobarbital suppress the dopaminergic neurotoxicity of MPTP in mice. Eur J Pharmacol 1986;128(3):255-257.