Skip to Main Content
It looks like you're using Internet Explorer 11 or older. This website works best with modern browsers such as the latest versions of Chrome, Firefox, Safari, and Edge. If you continue with this browser, you may see unexpected results.

Hadassah Medical Center: Naveh Tally

Last updated June 2021 - Hadassah Medical Center

List of Publications

(1) Egstrand S, Nordholm A, Morevati M, Mace ML, Hassan A, Naveh-Many T, et al. A molecular circadian clock operates in the parathyroid gland and is disturbed in chronic kidney disease associated bone and mineral disorder. Kidney Int 2020;98(6):1461-1475.

(2) Kilav-Levin R, Hassan A, Nechama M, Shilo V, Silver J, Ben-Dov IZ, et al. Post-transcriptional mechanisms regulating parathyroid hormone gene expression in secondary hyperparathyroidism. FEBS J 2020;287(14):2903-2913.

(3) Naveh-Many T, Volovelsky O. Parathyroid cell proliferation in secondary hyperparathyroidism of chronic kidney disease. Int J Mol Sci 2020;21(12):1-17.

(4) Naveh-Many T, Silver J, Kronenberg HM. Parathyroid hormone molecular biology. Principles of Bone Biology; 2019. p. 575-594.

(5) Durlacher-Betzer K, Hassan A, Levi R, Axelrod J, Silver J, Naveh-Many T. Interleukin-6 contributes to the increase in fibroblast growth factor 23 expression in acute and chronic kidney disease. Kidney Int 2018;94(2):315-325.

(6) Silver J, Naveh-Many T. Vitamin D and the Parathyroids. Vitamin D: Fourth Edition; 2018. p. 461-475.

(7) Naveh-Many T, Silver J. Transcription factors that determine parathyroid development power PTH expression. Kidney Int 2018;93(1):7-9.

(8) Shilo V, Levi IM-, Abel R, Mihailović A, Wasserman G, Naveh-Many T, et al. Let-7 and MicroRNA-148 regulate parathyroid hormone levels in secondary hyperparathyroidism. J Am Soc Nephrol 2017;28(8):2353-2363.

(9) Naveh-Many T, Silver J. The pas de trois of Vitamin D, FGF23, and PTH. J Am Soc Nephrol 2017;28(2):393-395.

(10) Shilo V, Silver J, Naveh-Many T. Micro-RNAs in the parathyroid: A new portal in understanding secondary hyperparathyroidism. Curr Opin Nephrol Hypertens 2016;25(4):271-277.

(11) Hassan A, Durlacher K, Silver J, Naveh-Many T, Levi R. The fibroblast growth factor receptor mediates the increased FGF23 expression in acute and chronic uremia. Am J Physiol Renal Physiol 2016;310(3):F217-F221.

(12) Volovelsky O, Cohen G, Kenig A, Wasserman G, Dreazen A, Meyuhas O, et al. Phosphorylation of ribosomal protein S6 mediates mammalian target of rapamycin complex 1-induced parathyroid cell proliferation in secondary hyperparathyroidism. J Am Soc Nephrol 2016;27(4):1091-1101.

(13) Naveh-Many T. Post-transcriptional regulation of parathyroid hormone gene expression in health and disease. Post-Transcriptional Mechanisms in Endocrine Regulation; 2015. p. 235-251.

(14) Shilo V, Ben-Dov IZ, Nechama M, Silver J, Naveh-Many T. Parathyroid-specific deletion of dicer-dependent microRNAs abrogates the response of the parathyroid to acute and chronic hypocalcemia and uremia. FASEB J 2015;29(9):3964-3976.

(15) Meir T, Durlacher K, Pan Z, Amir G, Richards WG, Silver J, et al. Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription. Kidney Int 2014;86(6):1106-1115.

(16) Silver J, Naveh-Many T. FGF-23 and secondary hyperparathyroidism in chronic kidney disease. Nat Rev Nephrol 2013;9(11):641-649.

(17) Tzour A, Sosial E, Meir T, Canello T, Naveh-Many T, Gabizon R, et al. Multiple Pathways for High Voltage-Activated Ca2+ Influx in Anterior Pituitary Lactotrophs and Somatotrophs. J Neuroendocrinol 2013;25(1):76-86.

(18) Silver J, Naveh-Many T. FGF23 and the parathyroid. Adv Exp Med Biol 2012;728:92-99.

(19) Naveh-Many T, Nechama M. Molecular mechanisms of parathyroid hormone synthesis. Diseases of the Parathyroid Glands; 2012. p. 1-12.

(20) Silver J, Naveh-Many T. Vitamin D and the parathyroids. Vitamin D; 2011. p. 493-506.

(21) Silver J, Naveh-Many T. FGF23 and the parathyroid glands. Pediatr Nephrol 2010;25(11):2241-2245.

(22) Lavi-Moshayoff V, Wasserman G, Meir T, Silver J, Naveh-Many T. PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: A bone parathyroid feedback loop. Am J Physiol Renal Physiol 2010;299(4):F882-F889.

(23) Naveh-Many T. Minireview: The play of proteins on the parathyroid hormone messenger ribonucleic acid regulates its expression. Endocrinology 2010;151(4):1398-1402.

(24) Galitzer H, Ben-Dov IZ, Silver J, Naveh-Many T. Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease. Kidney Int 2010;77(3):211-218.

(25) Meir T, Levi R, Lieben L, Libutti S, Carmeliet G, Bouillon R, et al. Deletion of the vitamin D receptor specifically in the parathyroid demonstrates a limited role for the receptor in parathyroid physiology. Am J Physiol Renal Physiol 2009;297(5):F1192-F1198.

(26) Nechama M, Uchida T, Yosef-Levi IM, Silver J, Naveh-Many T. The peptidyl-prolyl isomerase Pin1 determines parathyroid hormone mRNA levels and stability in rat models of secondary hyperparathyroidism. J Clin Invest 2009;119(10):3102-3114.

(27) Nechama M, Peng Y, Bell O, Briata P, Gherzi R, Schoenberg DR, et al. KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cells. BMC Cell Biol 2009;10:70.

(28) Lavi-Moshayoff V, Silver J, Naveh-Many T. Human PTH gene regulation in vivo using transgenic mice. Am J Physiol Renal Physiol 2009;297(3):F713-F719.

(29) Reiss-Sklan E, Levitzki A, Naveh-Many T. The complex regulation of HIC (Human I-mfa domain containing protein) expression. PLoS ONE 2009;4(7).

(30) Silver J, Naveh-Many T. Phosphate and the parathyroid. Kidney Int 2009;75(9):898-905.

(31) Galitzer H, Lavi-Moshayoff V, Nechama M, Meir T, Silver J, Naveh-Many T. The calcium-sensing receptor regulates parathyroid hormone gene expression in transfected HEK293 cells. BMC Biol 2009;7.

(32) Nechama M, Ben-Dov IZ, Silver J, Naveh-Many T. Regulation of PTH mRNA stability by the calcimimetic R568 and the phosphorus binder lanthanum carbonate in CKD. Am J Physiol Renal Physiol 2009;296(4):F795-F800.

(33) Naveh-Many T, Silver J, Kronenberg HM. Parathyroid Hormone. Molecular Biology. Principles of Bone Biology, Two-Volume Set; 2008. p. 577-593.

(34) Nechama M, Ben-Dov IZ, Briata P, Gherzi R, Naveh-Many T. The mRNA decay promoting factor K-homology splicing regulator protein post-transcriptionally determines parathyroid hormone mRNA levels. FASEB J 2008;22(10):3458-3468.

(35) Galitzer H, Ben-Dov I, Lavi-Moshayoff V, Naveh-Many T, Silver J. Fibroblast growth factor 23 acts on the parathyroid to decrease parathyroid hormone secretion. Curr Opin Nephrol Hypertens 2008;17(4):363-367.

(36) Ben-Dov IZ, Galitzer H, Lavi-Moshayoff V, Goetz R, Kuro-o M, Mohammadi M, et al. The parathyroid is a target organ for FGF23 in rats. J Clin Invest 2007;117(12):4003-4008.

(37) Naveh-Many T, Nechama M. Regulation of parathyroid hormone mRNA stability by calcium, phosphate and uremia. Curr Opin Nephrol Hypertens 2007;16(4):305-310.

(38) Ben-Dov IZ, Pappo O, Sklair-Levy M, Galitzer H, Ilan Y, Naveh-Many T, et al. Lanthanum carbonate decreases PTH gene expression with no hepatotoxicity in uraemic rats. Nephrol Dial Transplant 2007;22(2):362-368.

(39) Costa-Guda J, Lauter K, Naveh-Many T, Silver J, Arnold A. Mutational analysis of the PTH 3′-untranslated region in parathyroid disorders. Clin Endocrinol 2006;65(6):806-809.

(40) Dinur M, Kilav R, Sela-Brown A, Jacquemin-Sablon H, Naveh-Many T. In vitro evidence that upstream of N-ras participates in the regulation of parathyroid hormone messenger ribonucleic acid stability. Mol Endocrinol 2006;20(7):1652-1660.

(41) Levi R, Ben-Dov IZ, Lavi-Moshayoff V, Dinur M, Martin D, Naveh-Many T, et al. Increased parathyroid hormone gene expression in secondary hyperparathyroidism of experimental uremia is reversed by calcimimetics: Correlation with posttranslational modification of the trans acting factor AUF1. J Am Soc Nephrol 2006;17(1):107-112.

(42) Silver J, Naveh-Many T. Vitamin D and the Parathyroids. Vitamin D; 2005. p. 537-549.

(43) Totary-Jain H, Naveh-Many T, Riahi Y, Kaiser N, Eckel J, Sasson S. Calreticulin destabilizes glucose transporter-1 mRNA in vascular endothelial and smooth muscle cells under high-glucose conditions. Circ Res 2005;97(10):1001-1008.

(44) Bell O, Silver J, Naveh-Many T. Identification and characterization of cis-acting elements in the human and bovine PTH mRNA 3′-untranslated region. J Bone Miner Res 2005;20(5):858-866.

(45) Bell O, Gaberman E, Kilav R, Levi R, Cox KB, Molkentin JD, et al. The protein phosphatase calcineurin determines basal parathyroid hormone gene expression. Mol Endocrinol 2005;19(2):516-526.

(46) Moz Y, Levi R, Lavi-Moshayoff V, Cox KB, Molkentin JD, Silver J, et al. Calcineurin Aβ is central to the expression of the renal type II Na/Pi Co-transporter gene and to the regulation of renal phosphate transport. J Am Soc Nephrol 2004;15(12):2972-2980.

(47) Kilav R, Bell O, Le S-, Silver J, Naveh-Many T. The Parathyroid Hormone mRNA 3′-Untranslated Region AU-rich Element Is an Unstructured Functional Element. J Biol Chem 2004;279(3):2109-2116.

(48) Moz Y, Silver J, Naveh-Many T. Characterization of cis-acting element in renal NaPi-2 cotransporter mRNA that determines mRNA stability. Am J Physiol Renal Physiol 2003;284(4 53-4):F663-F670.

(49) Naveh-Many T, Bell O, Silver J, Kilav R. Cis and trans acting factors in the regulation of parathyroid hormone (PTH) mRNA stability by calcium and phosphate. FEBS Lett 2002;529(1):60-64.

(50) Silver J, Kilav R, Naveh-Many T. Mechanisms of secondary hyperparathyroidism. Am J Physiol Renal Physiol 2002;283(3 52-3):F367-F376.

(51) Kilav R, Silver J, Naveh-Many T. A Conserved cis-Acting Element in the Parathyroid Hormone 3′-Untranslated Region is Sufficient for Regulation of RNA Stability by Calcium and Phosphate. J Biol Chem 2001;276(12):8727-8733.

(52) Sela-Brown A, Silver J, Brewer G, Naveh-Many T. Identification of AUF1 as a parathyroid hormone mRNA 3'-untranslated region-binding protein that determines parathyroid hormone mRNA stability. J Biol Chem 2000;275(10):7424-7429.

(53) Silver J, Kilav R, Sela-Brown A, Naveh-Many T. Molecular mechanisms of secondary hyperparathyroidism. Pediatr Nephrol 2000;14(7):626-628.

(54) Epstein E, Sela-Brown A, Ringel I, Kilav R, King SM, Benashski SE, et al. Dynein light chain binding to a 3'-untranslated sequence mediates parathyroid hormone mRNA association with microtubules. J Clin Invest 2000;105(4):505-512.

(55) Naveh-Many T. Post-transcriptional regulation of the parathyroid hormone gene by calcium and phosphate. Curr Opin Nephrol Hypertens 1999;8(4):415-419.

(56) Yalcindag C, Silver J, Naveh-Many T. Mechanism of increased parathyroid hormone mRNA in experimental uremia: Roles of protein RNA binding and RNA degradation. J Am Soc Nephrol 1999;10(12):2562-2568.

(57) Moz Y, Silver J, Naveh-Many T. Protein-RNA interactions determine the stability of the renal NaPi-2 cotransporter mRNA and its translation in hypophosphatemic rats. J Biol Chem 1999;274(36):25266-25272.

(58) Sela-Brown A, Naveh-Many T, Silver J. Transcriptional and post-transcriptional regulation of PTH gene expression by vitamin D, calcium and phosphate. Miner Electrolyte Metab 1999;25(4-6):342-344.

(59) Naveh-Many T, Sela-Brown A, Silver J. Protein-RNA interactions in the regulation of PTH gene expression by calcium and phosphate. Nephrol Dial Transplant 1999;14(4):811-813.

(60) Silver J, Yalcindag C, Sela-Brown A, Kilav R, Naveh-Many T. Regulation of the parathyroid hormone gene by vitamin D, calcium and phosphate. Kidney Int Suppl 1999;56(73):S2-S7.

(61) Moallem E, Kilav R, Silver J, Naveh-Many T. RNA-protein binding and post-transcriptional regulation of parathyroid hormone gene expression by calcium and phosphate. J Biol Chem 1998;273(9):5253-5259.

(62) Silver J, Moallem E, Kilav R, Sela A, Naveh-Many T. Regulation of the parathyroid hormone gene by calcium, phosphate and 1,25-dihydroxyvitamin D. Nephrol Dial Transplant 1998;13(SUPPL. 1):40-44.

(63) Sela-Brown A, Russell J, Koszewski NJ, Michalak M, Naveh-Many T, Silver J. Calreticulin inhibits vitamin D's action on the PTH gene in vitro and may prevent vitamin D's effect in vivo in hypocalcemic rats. Mol Endocrinol 1998;12(8):1193-1200.

(64) Cohen Y, Rahamimov R, Naveh-Many T, Silver J, Rahamimoff R. Where is the "inverting factor" in hormone secretion from parathyroid cells? Am J Physiol 1997;273(3 PART 1):E584-E592.

(65) Marks KH, Kilav R, Berman E, Naveh-Many T, Silver J. Parathyroid hormone gene expression in Hyp mice fed a low-phosphate diet. Nephrol Dial Transplant 1997;12(8):1581-1585.

(66) Silver J, Sela SB, Naveh-Many T. Regulation of parathyroid cell proliferation. Curr Opin Nephrol Hypertens 1997;6(4):321-326.

(67) Cohen Y, Rahamimov R, Naveh-Many T, Silver J, Rahamimoff R. Where is the 'inverting factor' in hormone secretion from parathyroid cells? Am J Physiol Endocrinol Metab 1997;273(3 36-3):E630-E637.

(68) Silver J, Epstein E, Naveh-Many T. Oestrogen deficiency - Does it have a role in the genesis of skeletal problems in dialysed women? Nephrol Dial Transplant 1996;11(4):565-566.

(69) Marks KH, Kilav R, Naveh-Many T, Silver J. Calcium, phosphate, vitamin D, and the parathyroid. Pediatr Nephrol 1996;10(3):364-367.

(70) Epstein E, Silver J, Almogi G, Livni N, Naveh-Many T. Parathyroid hormone mRNA levels are increased by progestins and vary during rat estrous cycle. Am J Physiol Endocrinol Metab 1996;270(1 33-1):E158-E163.

(71) Silver J, Moallem E, Kilav R, Epstein E, Sela A, Naveh-Many T. New insights into the regulation of parathayroid hormone synthesis and secretion in chronic renal failure. Nephrol Dial Transplant 1996;11(SUPPL. 3):2-5.

(72) Lytton J, Lee S-, Lee W-, Van Baal J, Bindels RJM, Kilav R, et al. The kidney sodium-calcium exchanger. ANN NEW YORK ACAD SCI 1996;779:58-72.

(73) Kilav R, Silver J, Naveh-Many T. Parathyroid hormone gene expression in hypophosphatemic rats. J Clin Invest 1995;96(1):327-333.

(74) Naveh-Many T, Epstein E, Silver J. Oestrogens and calcium regulatory hormones: Potential implications for bone. Curr Opin Nephrol Hypertens 1995;4(4):319-323.

(75) Moallem E, Silver J, Naveh‐Many T. Regulation of parathyroid hormone messenger RNA levels by protein kinase A and C in bovine parathyroid cells. J Bone Miner Res 1995;10(3):447-452.

(76) Naveh-Many T, Rahamimov R, Livni N, Silver J. Parathyroid cell proliferation in normal and chronic renal failure rats. The effects of calcium, phosphate, and vitamin D. J Clin Invest 1995;96(4):1786-1793.

(77) Kilav R, Silver J, Biber J, Murer H, Naveh-Many T. Coordinate regulation of rat renal parathyroid hormone receptor mRNA and Na-P(i) cotransporter mRNA and protein. AM J PHYSIOL RENAL FLUID ELECTROLYTE PHYSIOL 1995;268(6 37-6):F1017-F1022.

(78) Silver J, Naveh-Many T. Regulation of parathyroid hormone synthesis and secretion. Semin Nephrol 1994;14(2):175-194.

(79) Silver J, Moallem E, Epstein E, Kilav R, Naveh-Many T. New aspects in the control of parathyroid hormone secretion. Curr Opin Nephrol Hypertens 1994;3(4):379-385.

(80) Silver J, Naveh-Many T. Calcitonin gene regulation in vivo. Horm Metab Res 1993;25(9):470-472.

(81) Naveh-Many T, Silver J. Effects of calcitriol, 22-oxacalcitriol, and calcipotriol on serum calcium and parathyroid hormone gene expression. Endocrinology 1993;133(6):2724-2728.

(82) Grauer A, Klein P, Naveh-Many T, Silver J, Ziegler R, Raue F. Diminished calcitonin secretion after ovariectomy without apparent reduction in calcitonin content in the rat. Horm Metab Res 1993;25(7):389-390.

(83) Naveh-Many T, Almogi G, Livni N, Silver J. Estrogen receptors and biologic response in rat parathyroid tissue and C cells. J Clin Invest 1992;90(6):2434-2438.

(84) Naveh‐Many T, Raue F, Grauer A, Silver J. Regulation of calcitonin gene expression by hypocalcemia, hypercalcemia, and vitamin D in the rat. J Bone Miner Res 1992;7(10):1233-1237.

(85) Shvil Y, Naveh-Many T, Barach P, Silver J. Regulation of parathyroid cell gene expression in experimental uremia. J Am Soc Nephrol 1990;1(1):99-104.

(86) Naveh-Many T, Silver J. Regulation of parathyroid hormone gene expression by hypocalcemia, hypercalcemia and vitamin D in the rat. J Clin Invest 1990;86(4):1313-1319.

(87) Regulation of parathyroid hormone and calcitonin gene expression by 1,25-dihydroxy vitamin D3 and calcium. Calcium regulation and bone metabolism. Basic and clinical aspects: proceedings of the 10th International Conference on calcium regulating hormones and bone metabolism. ICS886; 1990.

(88) Naveh-Many T, Marx R, Keshet E, Pike JW, Silver J. Regulation of 1,25-dihydroxyvitamin D3 receptor gene expression by 1,25-dihydroxyvitamin D3 in the parathyroid in vivo. J Clin Invest 1990;86(6):1968-1975.

(89) Naveh-Many T, Silver J. Regulation of calcitonin gene transcription by vitamin D metabolites in vivo in the rat. J Clin Invest 1988;81(1):270-273.

(90) Silver J, Naveh-Many T, Mayer H, Schmelzer HJ, Popovtzer MM. Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat. J Clin Invest 1986;78(5):1296-1301.

(91) Razin A, Webb C, Szyf M, Yisraeli J, Rosenthal A, Naveh-Many T, et al. Variations in DNA methylation during mouse cell differentiation in vivo and in vitro. Proc Natl Acad Sci U S A 1984;81(8 I):2275-2279.

(92) Naveh-Many T, Cedar H. Topographical distribution of 5-methylcytosine in animal and plant DNA. Mol Cell Biol 1982;2(7):758-762.

(93) Cedar H, Stein R, Gruenbaum Y, Naveh-Many T, Sciaky-Gallili N, Razin A. Effect of DNA methylation on gene expression. COLD SPRING HARBOR SYMP QUANT BIOL 1982;47(2):605-609.

(94) Gruenbaum Y, Naveh-many T, Cedar H, Razin A. Sequence specificity of methylation in higher plant DNA. Nature 1981;292(5826):860-862.

(95) Naveh-Many T, Cedar H. Active gene sequences are undermethylated. Proc Natl Acad Sci U S A 1981;78(7 I):4246-4250.