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The Faculty of Medicine - Developmental Biology and Cancer Research: Behar Oded

Researchers

Last updated June 2021 - Developmental Biology and Cancer Research

List of Publications

(1) Birger A, Ben-Dor I, Ottolenghi M, Turetsky T, Gil Y, Sweetat S, et al. Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity. EBioMedicine 2019;50:274-289.

(2) Casden N, Behar O. An approach for accelerated isolation of genetically manipulated cell clones with reduced clonal variability. J Cell Sci 2019;132(6).

(3) Peretz L, Besser E, Hajbi R, Casden N, Ziv D, Kronenberg N, et al. Combined shRNA over CRISPR/cas9 as a methodology to detect off-target effects and a potential compensatory mechanism. Sci Rep 2018;8(1).

(4) Maimon R, Ionescu A, Bonnie A, Sweetat S, Wald-Altman S, Inbar S, et al. Mir126-5p downregulation facilitates axon degeneration and nmj disruption via a non–cell-autonomous mechanism in ALS. J Neurosci 2018;38(24):5478-5494.

(5) Birger A, Ottolenghi M, Perez L, Reubinoff B, Behar O. ALS-related human cortical and motor neurons survival is differentially affected by Sema3A article. Cell Death Dis 2018;9(3).

(6) Gal-Mark N, Shallev L, Sweetat S, Barak M, Billy Li J, Levanon EY, et al. Abnormalities in A-to-I RNA editing patterns in CNS injuries correlate with dynamic changes in cell type composition. Sci Rep 2017;7.

(7) Chadwick EJ, Yang DP, Filbin MG, Mazzola E, Sun Y, Behar O, et al. A brain tumor/organotypic slice co-culture system for studying tumor microenvironment and targeted drug therapies. J Visualized Exp 2015;2015(105).

(8) Birger A, Besser E, Reubinoff B, Behar O. A new impedance based approach to test the activity of recombinant protein - Semaphorins as a test case. Eur J Cell Biol 2015;94(10):453-457.

(9) Ben-Gigi L, Sweetat S, Besser E, Fellig Y, Wiederhold T, Polakiewicz RD, et al. Astrogliosis induced by brain injury is regulated by sema4B phosphorylation. eNeuro 2015;2(3).

(10) Ben-Zvi A, Sweetat S, Behar O. Elimination of Aberrant DRG Circuitries in Sema3A Mutant Mice Leads to Extensive Neuronal Deficits. PLoS ONE 2013;8(7).

(11) Ben-Zvi A, Manor O, Schachner M, Yaron A, Tessier-Lavigne M, Behar O. The semaphorin receptor PlexinA3 mediates neuronal apoptosis during dorsal root ganglia development. J Neurosci 2008;28(47):12427-12432.

(12) Ben-Zvi A, Ben-Gigi L, Yagil Z, Lerman O, Behar O. Semaphorin3A regulates axon growth independently of growth cone repulsion via modulation of TrkA signaling. Cell Signal 2008;20(3):467-479.

(13) Ben-Zvi A, Ben-Gigi L, Klein H, Behar O. Modulation of semaphorin3A activity by p75 neurotrophin receptor influences peripheral axon patterning. J Neurosci 2007;27(47):13000-13011.

(14) Lerman O, Ben-Zvi A, Yagil Z, Behar O. Semaphorin3A accelerates neuronal polarity in vitro and in its absence the orientation of DRG neuronal polarity in vivo is distorted. Mol Cell Neurosci 2007;36(2):222-234.

(15) Ben-Zvi A, Yagil Z, Hagalili Y, Klein H, Lerman O, Behar O. Semaphorin 3A and neurotrophins: A balance between apoptosis and survival signaling in embryonic DRG neurons. J Neurochem 2006;96(2):585-597.

(16) Kettunen P, Løes S, Furmanek T, Fjeld K, Kvinnsland IH, Behar O, et al. Coordination of trigeminal axon navigation and patterning with tooth organ formation: Epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfβ1 regulate semaphorin 3a expression in the dental mesenchyme. Development (Cambridge) 2005;132(2):323-334.

(17) White FA, Behar O. The development and subsequent elimination of aberrant peripheral axon projections in Semaphorin3A null mutant mice. Dev Biol 2000;225(1):79-86.

(18) Behar O, Mizuno K, Neumann S, Woolf CJ. Putting the spinal cord together again. Neuron 2000;26(2):291-293.

(19) Behar O, Mizuno K, Badminton M, Woolf CJ. Semaphorin 3A growth cone collapse requires a sequence homologous to tarantula hanatoxin. Proc Natl Acad Sci U S A 1999;96(23):13501-13505.

(20) Borsook D, Smirnova O, Behar O, Lewis S, Kobierski LA. PhosphoCREB and CREM/ICER: Positive and negative regulation of proenkephalin gene expression in the paraventricular nucleus of the hypothalamus. J Mol Neurosci 1999;12(1):35-51.

(21) Ulupinar E, Datwani A, Behar O, Fujisawa H, Erzurumlu R. Role of semaphorin III in the developing rodent trigeminal system. Mol Cell Neurosci 1999;13(4):281-292.

(22) Eckhardt F, Behar O, Calautti E, Yonezawa K, Nishimoto I, Fishman MC. A novel transmembrane semaphorin can bind c-src. Mol Cell Neurosci 1997;9(5-6):409-419.

(23) Behar O, Golden JA, Mashimo H, Schoen FJ, Fishman MC. Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Nature 1996;383(6600):525-528.

(24) Ovadia H, Magenheim Y, Behar O, Rosen H. Molecular characterization of immune derived proenkephalin mRNA and the involvement of the adrenergic system in its expression in rat lymphoid cells. J Neuroimmunol 1996;68(1-2):77-83.

(25) Behar O, Ovadia H, Polakiewicz RD, Rosen H. Lipopolysaccharide induces proenkephalin gene expression in rat lymph nodes and adrenal glands. Endocrinology 1994;134(1):475-481.

(26) Polakiewicz RD, Behar OZ, Comb MJ, Rosen H. Regulation of proenkephalin expression in cultured skin mesenchymal cells. Mol Endocrinol 1992;6(3):399-408.

(27) Behar OZ, Ovadia H, Polakiewicz RD, Abramsky O, Rosen H. Regulation of proenkephalin A messenger ribonucleic acid levels in normal B lymphocytes: Specific inhibition by glucocorticoid hormones and superinduction by cycloheximide. Endocrinology 1991;129(2):649-655.

(28) OVADIA H, BEHAR O, ABRAMSKY O, ROSEN H. Regulated Expression of Opioid Genes in Normal Rat Lymphocytes. Ann New York Acad Sci 1990;594(1):485-488.

(29) Rosen H, Behar O, Abramsky O, Ovadia H. Regulated expression of proenkephalin A in normal lymphocytes. J Immunol 1989;143(11):3703-3707.