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The Faculty of Medicine - Developmental Biology and Cancer Research: Ben-Porath Ittai


 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Kolodkin-Gal D, Roitman L, Ovadya Y, Azazmeh N, Assouline B, Schlesinger Y, et al. Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions. Gut 2021.

(2) Azazmeh N, Assouline B, Winter E, Ruppo S, Nevo Y, Maly A, et al. Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation. Nat Commun 2020;11(1).

(3) Azazmeh N, Ben-Porath I. Stimulation of epidermal hyperplasia and tumorigenesis by resident p16INK4a-expressing cells. Mol Cell Oncol 2020;7(6).

(4) Borghesan M, Fafián-Labora J, Eleftheriadou O, Carpintero-Fernández P, Paez-Ribes M, Vizcay-Barrena G, et al. Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3. Cell Rep 2019;27(13):3956-3971.e6.

(5) Granit RZ, Masury H, Condiotti R, Fixler Y, Gabai Y, Glikman T, et al. Regulation of Cellular Heterogeneity and Rates of Symmetric and Asymmetric Divisions in Triple-Negative Breast Cancer. Cell Rep 2018;24(12):3237-3250.

(6) Grinshpun A, Gavert N, Granit RZ, Masuri H, Ben-Porath I, Breuer S, et al. Ev vivo organ culture as potential prioritization tool for breast cancer targeted therapy. Cancer Biol Ther 2018;19(8):645-648.

(7) Tarcic O, Granit RZ, Pateras IS, Masury H, Maly B, Zwang Y, et al. RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer. Cell Death Differ 2017;24(4):694-704.

(8) Helman A, Avrahami D, Klochendler A, Glaser B, Kaestner KH, Ben-Porath I, et al. Effects of ageing and senescence on pancreatic β-cell function. Diabetes Obes Metab 2016;18:58-62.

(9) Yosef R, Pilpel N, Tokarsky-Amiel R, Biran A, Ovadya Y, Cohen S, et al. Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL. Nat Commun 2016;7.

(10) Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, et al. p16 Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion. Nat Med 2016;22(4):412-420.

(11) Ben-Porath I. Active, dormant, or on the path to elimination: What does a senescent cell do? Tumor Dormancy, Quiescence, and Senescence: Aging, Cancer, and Noncancer Pathologies; 2014. p. 3-12.

(12) Ben-Porath I. Preface: stem cells and oncogenesis. Crit Rev Oncog 2014;19(5):v-vi.

(13) Condiotti R, Guo W, Ben-Porath I. Evolving views of breast cancer stem cells and their differentiation states. Crit Rev Oncog 2014;19(5):337-348.

(14) Granit RZ, Slyper M, Ben-Porath I. Axes of differentiation in breast cancer: Untangling stemness, lineage identity, and the epithelial to mesenchymal transition. Wiley Interdiscip Rev Syst Biol Med 2014;6(1):93-106.

(15) Strauss C, Kornowski M, Benvenisty A, Shahar A, Masury H, Ben-Porath I, et al. The DNA2 nuclease/helicase is an estrogen-dependent gene mutated in breast and ovarian cancers. Oncotarget 2014;5(19):9396-9409.

(16) Granit RZ, Gabai Y, Hadar T, Karamansha Y, Liberman L, Waldhorn I, et al. EZH2 promotes a bi-lineage identity in basal-like breast cancer cells. Oncogene 2013;32(33):3886-3895.

(17) Tokarsky-Amiel R, Azazmeh N, Helman A, Stein Y, Hassan A, Maly A, et al. Dynamics of senescent cell formation and retention revealed by p14 ARF induction in the epidermis. Cancer Res 2013;73(9):2829-2839.

(18) Sebban S, Farago M, Gashai D, Ilan L, Pikarsky E, Ben-Porath I, et al. Vav1 Fine Tunes p53 Control of Apoptosis versus Proliferation in Breast Cancer. PLoS ONE 2013;8(1).

(19) Grinshpun A, Ben-Porath I, Peretz T, Salmon A. [Tumor, metastasis and what's in between]. Harefuah 2013;152(1):30-"33, 59, 58".

(20) Slyper M, Shahar A, Bar-Ziv A, Granit RZ, Hamburger T, Maly B, et al. Control of breast cancer growth and initiation by the stem cell-associated transcription factor TCF3. Cancer Res 2012;72(21):5613-5624.

(21) Pradeep C-, Köstler WJ, Lauriola M, Granit RZ, Zhang F, Jacob-Hirsch J, et al. Modeling ductal carcinoma in situ: A HER2-Notch3 collaboration enables luminal filling. Oncogene 2012;31(7):907-917.

(22) Kojima Y, Acar A, Eaton EN, Mellody KT, Scheel C, Ben-Porath I, et al. Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci U S A 2010;107(46):20009-20014.

(23) Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A, et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008;40(5):499-507.

(24) Lande-Diner L, Zhang J, Ben-Porath I, Amariglio N, Keshet I, Hecht M, et al. Role of DNA methylation in stable gene repression. J Biol Chem 2007;282(16):12194-12200.

(25) Ben-Porath I, Weinberg RA. The signals and pathways activating cellular senescence. Int J Biochem Cell Biol 2005;37(5 SPEC. ISS.):961-976.

(26) Rand E, Ben-Porath I, Keshet I, Cedar H. CTCF elements direct allele-specific undermethylation at the imprinted H19 locus. Curr Biol 2004;14(11):1007-1012.

(27) Jørgensen HF, Ben-Porath I, Bird AP. Mbd1 Is Recruited to both Methylated and Nonmethylated CpGs via Distinct DNA Binding Domains. Mol Cell Biol 2004;24(8):3387-3395.

(28) Ben-Porath I, Weinberg RA. When cells get stressed: An integrative view of cellular senescence. J Clin Invest 2004;113(1):8-13.

(29) Masutomi K, Yu EY, Khurts S, Ben-Porath I, Currier JL, Metz GB, et al. Telomerase maintains telomere structure in normal human cells. Cell 2003;114(2):241-253.

(30) Stewart SA, Ben-Porath I, Carey VJ, O'Connor BF, Hahn WC, Weinberg RA. Erosion of the telomeric single-strand overhang at replicative senescence. Nat Genet 2003;33(4):492-496.

(31) Ben-Porath I, Cedar H. Epigenetic crosstalk. Mol Cell 2001;8(5):933-935.

(32) Ben-Porath I, Cedar H. Imprinting: Focusing on the center. Curr Opin Genet Dev 2000;10(5):550-554.

(33) Ben-Porath I, Yanuka O, Benvenisty N. The Tmp gene, encoding a membrane protein, is a c-Myc target with a tumorigenic activity. Mol Cell Biol 1999;19(5):3529-3539.

(34) Ben-Porath I, Kozak CA, Benvenisty N. Chromosomal mapping of Tmp (Emp 1), Xmp (Emp2), and Ymp (Emp3), genes encoding membrane proteins related to Pmp22. Genomics 1998;49(3):443-447.

(35) Ben-Porath I, Benvenisty N. Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins. Gene 1996;183(1-2):69-75.