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The Faculty of Medicine - Developmental Biology and Cancer Research: Bergman Yehudit


Last updated December 2021 - Developmental Biology and Cancer Research

List of Publications

(1) Blumenfeld B, Masika H, Farago M, Yehuda Y, Halaseh L, Vardi O, et al. Chromosomal coordination and differential structure of asynchronous replicating regions. Nat Commun 2021;12(1).

(2) Bergman Y, Simon I, Cedar H. Asynchronous Replication Timing: A Mechanism for Monoallelic Choice During Development. Front Cell Dev Biol 2021;9.

(3) Ansari I, Raddatz G, Gutekunst J, Ridnik M, Cohen D, Abu-Remaileh M, et al. The microbiota programs DNA methylation to control intestinal homeostasis and inflammation. Nat Microbiol 2020;5(4):610-619.

(4) Falick Michaeli T, Spiro A, Sabag O, Karavani G, Yagel S, Eventov-Friedman S, et al. Determining gestational age using genome methylation profile: A novel approach for fetal medicine. Prenat Diagn 2019;39(11):1005-1010.

(5) Bormann F, Rodríguez-Paredes M, Lasitschka F, Edelmann D, Musch T, Benner A, et al. Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis. Cell Rep 2018;23(11):3407-3418.

(6) Levin-Klein R, Fraenkel S, Lichtenstein M, Matheson LS, Bartok O, Nevo Y, et al. Clonally stable Vκ allelic choice instructs Igκ repertoire. Nat Commun 2017;8.

(7) Masika H, Farago M, Hecht M, Condiotti R, Makedonski K, Buganim Y, et al. Programming asynchronous replication in stem cells. Nat Struct Mol Biol 2017;24(12):1132-1138.

(8) Orlanski S, Labi V, Reizel Y, Spiro A, Lichtenstein M, Levin-Klein R, et al. Tissue-specific DNA demethylation is required for proper B-cell differentiation and function. Proc Natl Acad Sci U S A 2016;113(18):5018-5023.

(9) Levin-Klein R, Bergman Y. Regulation of IgL Chain Recombination. Encyclopedia of Immunobiology; 2016. p. 71-77.

(10) Aran D, Abu-Remaileh M, Levy R, Meron N, Toperoff G, Edrei Y, et al. Embryonic Stem Cell (ES)-Specific Enhancers Specify the Expression Potential of ES Genes in Cancer. PLoS Genet 2016;12(2).

(11) Michaeli TF, Laufer N, Sagiv JY, Dreazen A, Granot Z, Pikarsky E, et al. The rejuvenating effect of pregnancy on muscle regeneration. Aging Cell 2015;14(4):698-700.

(12) Abu-Remaileh M, Bender S, Raddatz G, Ansari I, Cohen D, Gutekunst J, et al. Chronic inflammation induces a novel epigenetic program that is conserved in intestinal adenomas and in colorectal cancer. Cancer Res 2015;75(10):2120-2130.

(13) Falick Michaeli T, Bergman Y, Gielchinsky Y. Rejuvenating effect of pregnancy on the mother. Fertil Steril 2015;103(5):1125-1128.

(14) Ludwig G, Nejman D, Hecht M, Orlanski S, Abu-Remaileh M, Yanuka O, et al. Aberrant DNA methylation in ES cells. PLoS ONE 2014;9(5).

(15) Popowski M, Templeton TD, Lee B-, Rhee C, Li H, Miner C, et al. Bright/Arid3A acts as a barrier to somatic cell reprogramming through direct regulation of Oct4, Sox2, and Nanog. Stem Cell Rep 2014;2(1):26-35.

(16) Levin-Klein R, Bergman Y. Epigenetic regulation of monoallelic rearrangement (allelic exclusion) of antigen receptor genes. Front Immunol 2014;5(DEC).

(17) Levin-Klein R, Kirillov A, Rosenbluh C, Cedar H, Bergman Y. A novel Pax5-binding regulatory element in the Igk locus. Front Immunol 2014;5(MAY).

(18) Bergman Y, Cedar H. DNA methylation dynamics in health and disease. Nat Struct Mol Biol 2013;20(3):274-281.

(19) Farago M, Rosenbluh C, Tevlin M, Fraenkel S, Schlesinger S, Masika H, et al. Clonal allelic predetermination of immunoglobulin-κ rearrangement. Nature 2012;490(7421):561-565.

(20) Cedar H, Bergman Y. Programming of DNA methylation patterns. Annu Rev Biochem 2012;81:97-117.

(21) Orlanski S, Bergman Y. MicroRNAs in embryonic stem cells. Epigenomics: From Chromatin Biology to Therapeutics; 2012. p. 163-178.

(22) Cedar H, Bergman Y. Epigenetics of haematopoietic cell development. Nat Rev Immunol 2011;11(7):478-488.

(23) Bergman Y, Cedar H. Epigenetic control of recombination in the immune system. Semin Immunol 2010;22(6):323-329.

(24) Abu-Remaileh M, Gerson A, Farago M, Nathan G, Alkalay I, Zins Rousso S, et al. Oct-3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/β-catenin signalling. EMBO J 2010;29(19):3236-3248.

(25) Gielchinsky Y, Laufer N, Weitman E, Abramovitch R, Granot Z, Bergman Y, et al. Pregnancy restores the regenerative capacity of the aged liver via activation of an mTORC1-controlled hyperplasia/hypertrophy switch. Genes Dev 2010;24(6):543-548.

(26) Schlesinger S, Selig S, Bergman Y, Cedar H. Allelic inactivation of rDNA loci. Genes Dev 2009;23(20):2437-2447.

(27) Cedar H, Bergman Y. Linking DNA methylation and histone modification: Patterns and paradigms. Nat Rev Gen 2009;10(5):295-304.

(28) Epsztejn-Litman S, Feldman N, Abu-Remaileh M, Shufaro Y, Gerson A, Ueda J, et al. De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes. Nat Struct Mol Biol 2008;15(11):1176-1183.

(29) Cedar H, Bergman Y. Choreography of Ig allelic exclusion. Curr Opin Immunol 2008;20(3):308-317.

(30) Fraenkel S, Mostoslavsky R, Novobrantseva TI, Pelanda R, Chaudhuri J, Esposito G, et al. Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin κ-chain locus. Nat Immunol 2007;8(7):715-722.

(31) Schlesinger Y, Straussman R, Keshet I, Farkash S, Hecht M, Zimmerman J, et al. Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat Genet 2007;39(2):232-236.

(32) Fraenkel S, Bergman Y. Variability and exclusion in host and parasite: Epigenetic regulation of Ig and var expression. J Immunol 2006;177(9):5767-5774.

(33) Feldman N, Gerson A, Fang J, Li E, Zhang Y, Shinkai Y, et al. G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Nature Cell Biol 2006;8(2):188-194.

(34) Goldmit M, Ji Y, Skok J, Roldan E, Jung S, Cedar H, et al. Epigenetic ontogeny of the Igk locus during B cell development. Nat Immunol 2005;6(2):198-203.

(35) Bergman Y, Cedar H. A stepwise epigenetic process controls immunoglobulin allelic exclusion. Nat Rev Immunol 2004;4(10):753-761.

(36) Goldmit M, Bergman Y. Monoallelic gene expression: A repertoire of recurrent themes. Immunol Rev 2004;200:197-214.

(37) Ji Y, Zhang J, Lee AI, Cedar H, Bergman Y. A multistep mechanism for the activation of rearrangement in the immune system. Proc Natl Acad Sci U S A 2003;100(13):7557-7562.

(38) Singh N, Bergman Y, Cedar H, Chess A. Biallelic germline transcription at the κ immunoglobulin locus. J Exp Med 2003;197(6):743-750.

(39) Gidekel S, Pizov G, Bergman Y, Pikarsky E. Oct-3/4 is a dose-dependent oncogenic fate determinant. Cancer Cell 2003;4(5):361-370.

(40) Bergman Y, Fisher A, Cedar H. Epigenetic mechanisms that regulate antigen receptor gene expression. Curr Opin Immunol 2003;15(2):176-181.

(41) Goldmit M, Schlissel M, Cedar H, Bergman Y. Differential accessibility at the κ chain locus plays a role in allelic exclusion. EMBO J 2002;21(19):5255-5261.

(42) Gidekel S, Bergman Y. A unique developmental pattern of Oct-3/4 DNA methylation is controlled by a cis-demodification element. J Biol Chem 2002;277(37):34521-34530.

(43) Mostoslavsky R, Singh N, Tenzen T, Goldmit M, Gabay C, Elizur S, et al. Asynchronous replication and allelic exclusion in the immune system. Nature 2001;414(6860):221-225.

(44) Barnea E, Bergman Y. Synergy of SF1 and RAR in activation of Oct-3/4 promoter. J Biol Chem 2000;275(9):6608-6619.

(45) Cedar H, Bergman Y. Developmental regulation of immune system gene rearrangement. Curr Opin Immunol 1999;11(1):64-69.

(46) Mostoslavsky R, Kirillov A, Ji Y-, Goldmit M, Holzmann M, Wirth T, et al. Demethylation and the establishment of κ allelic exclusion. Cold Spring Harbor Symp Quant Biol 1999;64:197-206.

(47) Bergman Y. Allelic exclusion in B and T lymphopoiesis. Semin Immunol 1999;11(5):319-328.

(48) Mostoslavsky R, Singh N, Kirillov A, Pelanda R, Cedar H, Chess A, et al. κ chain monoallelic demethylation and the establishment of allelic exclusion. Genes Dev 1998;12(12):1801-1811.

(49) Baumann B, Kistler B, Kirillov A, Bergman Y, Wirth T. The mutant plasmacytoma cell line S107 allows the identification of distinct pathways leading to NF-κB activation. J Biol Chem 1998;273(19):11448-11455.

(50) Ben-Shushan E, Thompson JR, Gudas LJ, Bergman Y. Rex-1, a gene encoding a transcription factor expressed in the early embryo, is regulated via Oct-3/4 and Oct-6 binding to an octamer site and a novel protein, Rox-1, binding to an adjacent site. Mol Cell Biol 1998;18(4):1866-1878.

(51) Bergman Y, Mostoslavsky R. DNA Déméthylation: Turning Genes On. Biol Chem Hoppe-Seyler 1998;379(4-5):401-408.

(52) Mostoslavsky R, Bergman Y. DNA methylation: Regulation of gene expression and role in the immune system. BIOCHIM BIOPHYS ACTA REV CANCER 1997;1333(1):F29-F50.

(53) Kistler B, Baumann B, Bergman Y, Wirth T. RelB is a key player for both κB-dependent transcription and demethylation in B cells. Immunobiology 1997;198(1-3):24-34.

(54) Bergman Y, Kirillov A, Kistler B, Mostoslavsky R, Cedar H, Wirth T. Nuclear nf-κb is essential for b-cell specific demethylation of the igκ locus. FASEB J 1996;10(6).

(55) Shurman L, Laskov R, Bergman Y. Identification of two novel negative regulatory elements in the tcrα gene. FASEB J 1996;10(6).

(56) Kirillov A, Kistler B, Mostoslavsky R, Cedar H, Wirth T, Bergman Y. A role for nuclear NF-κB in B-cell-specific demethylation of the Igκ locus. Nat Genet 1996;13(4):435-441.

(57) Shurman L, Laskov R, Bergman Y. Direct and indirect mechanisms of repression participate in suppression of T-cell-specific gene expression in T x L-cell hybrids. Gene Expr 1996;5(6):285-300.

(58) Reich L, Sharir H, Ber R, Wirth T, Bergman Y, Laskov R. Coordinate suppression of myeloma-specific genes and expression of fibroblast-specific genes in myeloma X fibroblast somatic cell hybrids. SOMATIC CELL MOL GENET 1996;22(1):1-20.

(59) Ben-Shushan E, Sharir H, Pikarsky E, Bergman Y. A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells. Mol Cell Biol 1995;15(2):1034-1048.

(60) Lichtenstein M, Keini G, Cedar H, Bergman Y. B cell-specific demethylation: A novel role for the intronic κ chain enhancer sequence. Cell 1994;76(5):913-923.

(61) Pikarsky E, Sharir H, Ben-Shushan E, Bergman Y. Retinoic acid represses Oct-3/4 gene expression through several retinoic acid-responsive elements located in the promoter-enhancer region. Mol Cell Biol 1994;14(2):1026-1038.

(62) Ben-Shushan E, Pikarsky E, Klar A, Bergman Y. Extinction of Oct-3/4 gene expression in embryonal carcinoma x fibroblast somatic cell hybrids is accompanied by changes in the methylation status, chromatin structure, and transcriptional activity of the Oct-3/4 upstream region. Mol Cell Biol 1993;13(2):891-901.

(63) Frank D, Lichtenstein M, Paroush Z, Bergman Y, Shani M, Razin A, et al. Demethylation of genes in animal cells. Philos Trans R Soc Lond , B, Biol Sci 1990;326(1235):241-251.

(64) Bergman Y, Strich B, Sharir H, Ber R, Laskov R. Extinction of Ig genes expression in myeloma x fibroblast somatic cell hybrids is accompanied by repression of the oct-2 gene encoding a B-cell specific transcription factor. EMBO J 1990;9(3):849-855.

(65) Greenberg A, Huazzi M, Sharir H, Cohen L, Bergman Y, Ber R, et al. Extinction of expression of the translocated myc gene in somatic cell hybrids between mouse myeloma and l‐cells. Int J Cancer 1989;43(1):87-92.

(66) Schwarzbaum S, Nissim A, Alkalay I, Ghozi MC, Schindler DG, Bergman Y, et al. Mapping of murine IgE epitopes involved in IgE‐Fcε receptor interactions. Eur J Immunol 1989;19(6):1015-1023.

(67) Shurman L, Sen R, Bergman Y. Adenovirus E1A products activate the Ig k-chain enhancer in fibroblasts. A possible involvement of the NF-kB binding site. J Immunol 1989;143(11):3806-3812.

(68) Liu JK, Bergman Y, Zaret KS. The mouse albumin promoter and a distal upstream site are simultaneously DNase I hypersensitive in liver chromatin and bind similar liver-abundant factors in vitro. Genes Dev 1988;2(5):528-541.

(69) Bergman Y, Shavit D. Regulation of the Ig κ-chain enhancer by the adenovirus E1A gene products. Repression in lymphoid cells, activation in fibroblasts. J Immunol 1988;140(6):2073-2080.

(70) Einat P, Bergman Y, Yaffe D, Shani M. Expression in transgenic mice of two genes of different tissue specificity integrated into a single chromosomal site. Genes Dev 1987;1(10):1075-1084.

(71) Bergman Y, Rice D, Grosschedl R, Baltimore D. Two regulatory elements for immunoglobulin κ light chain gene expression. Proc Natl Acad Sci U S A 1984;81(22 I):7041-7045.

(72) Bergman Y, Stewart SJ, Levy S, Levy R. Biosynthesis, glycosylation, and in vitro translation of the human T cell antigen Leu-4. J Immunol 1983;131(4):1876-1881.

(73) Bergman Y, Levy R. Biosynthesis and processing of a human T lymphocyte antigen. J Immunol 1982;128(3):1334-1340.

(74) Levy R, Bergman Y, Finn O. Hybridoma monoclonal antibodies in the analysis fo human cell surface antigens. In Vitro 1981;17(12):1051-1057.

(75) Eshhar Z, Blatt C, Bergman Y, Haimovich J. Induction of secretion of IgM from cells of the B cell line 38C-13 by somatic cell hybridization. J Immunol 1979;122(6):2430-2434.

(76) Bergman Y, Haimovich J. B lymphocytes contain three species of μ chains. Eur J Immunol 1978;8(12):876-880.

(77) Gabison D, Bergman Y, Haimovich J, Berke G. Immunoglobulins detected in cell populations involved in graft rejection. Transplant Proc 1977;9(1):741-745.

(78) Bergman Y, Haimovich J. Characterization of a carcinogen‐induced murine B lymphocyte cell line of C3H/eB origin. Eur J Immunol 1977;7(7):413-417.

(79) Bergman Y, Haimovich J, Melchers F. An IgM‐producing tumor with biochemical characteristics of a small B lymphocyte. Eur J Immunol 1977;7(8):574-579.

(80) Haimovich J, Bergman Y, Linker‐Israeli M, Haran‐Ghera N. Cell surface components of carcinogen‐induced lymphoid tumors in SJL/J mice. Eur J Immunol 1977;7(4):226-230.