Skip to Main Content
It looks like you're using Internet Explorer 11 or older. This website works best with modern browsers such as the latest versions of Chrome, Firefox, Safari, and Edge. If you continue with this browser, you may see unexpected results.

The Faculty of Medicine - Developmental Biology and Cancer Research: Dor Yuval


Last updated December 2021 - Developmental Biology and Cancer Research

List of Publications

(1) Fox-Fisher I, Piyanzin S, Ochana B-, Klochendler A, Magenheim J, Peretz A, et al. Remote immune processes revealed by immune-derived circulating cell-free dna. eLife 2021;10.

(2) Kaestner KH, Campbell-Thompson M, Dor Y, Gill RG, Glaser B, Kim SK, et al. What is a β cell? – Chapter I in the Human Islet Research Network (HIRN) review series. Mol Metab 2021;53.

(3) Li B, Wang Y, Pelz C, Moss J, Shemer R, Dor Y, et al. In vitro expansion of cirrhosis derived liver epithelial cells with defined small molecules. Stem Cell Res 2021;56.

(4) Tornovsky-Babeay S, Weinberg-Corem N, Ben-Haroush Schyr R, Avrahami D, Lavi J, Feleke E, et al. Biphasic dynamics of beta cell mass in a mouse model of congenital hyperinsulinism: implications for type 2 diabetes. Diabetologia 2021;64(5):1133-1143.

(5) Sadeh R, Sharkia I, Fialkoff G, Rahat A, Gutin J, Chappleboim A, et al. Author Correction: ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin (Nature Biotechnology, (2021), 39, 5, (586-598), 10.1038/s41587-020-00775-6). Nat Biotechnol 2021;39(5):642.

(6) Sadeh R, Sharkia I, Fialkoff G, Rahat A, Gutin J, Chappleboim A, et al. ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin. Nat Biotechnol 2021;39(5):586-598.

(7) Barak N, Ami RB, Sido T, Perri A, Shtoyer A, Rivkin M, et al. Lessons from applied large-scale pooling of 133,816 SARS-CoV-2 RT-PCR tests. Sci Transl Med 2021;13(589).

(8) Bronkhorst AJ, Ungerer V, Diehl F, Anker P, Dor Y, Fleischhacker M, et al. Towards systematic nomenclature for cell-free DNA. Hum Genet 2021;140(4):565-578.

(9) Kolodkin-Gal D, Roitman L, Ovadya Y, Azazmeh N, Assouline B, Schlesinger Y, et al. Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions. Gut 2021.

(10) Petrenko V, Stolovich-Rain M, Vandereycken B, Giovannoni L, Storch K-, Dor Y, et al. The core clock transcription factor BMAL1 drives circadian β-cell proliferation during compensatory regeneration of the endocrine pancreas. Genes Dev 2020;34(23-24):1650-1665.

(11) Ben-Ami R, Klochendler A, Seidel M, Sido T, Gurel-Gurevich O, Yassour M, et al. Large-scale implementation of pooled RNA extraction and RT-PCR for SARS-CoV-2 detection. Clin Microbiol Infect 2020;26(9):1248-1253.

(12) Segal E, Zhang F, Lin X, King G, Shalem O, Shilo S, et al. Publisher Correction: Building an international consortium for tracking coronavirus health status (Nature Medicine, (2020), 26, 8, (1161-1165), 10.1038/s41591-020-0929-x). Nat Med 2020;26(8):1309.

(13) Segal E, Zhang F, Lin X, King G, Shalem O, Shilo S, et al. Building an international consortium for tracking coronavirus health status. Nat Med 2020;26(8):1161-1165.

(14) Neiman D, Gillis D, Piyanzin S, Cohen D, Fridlich O, Moss J, et al. Multiplexing DNA methylation markers to detect circulating cell-free DNA derived from human pancreatic β cells. JCI Insight 2020;5(14).

(15) Rossman H, Keshet A, Shilo S, Gavrieli A, Bauman T, Cohen O, et al. A framework for identifying regional outbreak and spread of COVID-19 from one-minute population-wide surveys. Nat Med 2020;26(5):634-638.

(16) Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, et al. Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice (Nature Biotechnology, (2014), 32, 1, (76-83), 10.1038/nbt.2747). Nat Biotechnol 2020;38(3):374.

(17) Moss J, Zick A, Grinshpun A, Carmon E, Maoz M, Ochana BL, et al. Circulating breast-derived DNA allows universal detection and monitoring of localized breast cancer. Ann Oncol 2020;31(3):395-403.

(18) Speake C, Ylescupidez A, Neiman D, Shemer R, Glaser B, Tersey SA, et al. Circulating Unmethylated Insulin DNA As a Biomarker of Human Beta Cell Death: A Multi-laboratory Assay Comparison. J Clin Endocrinol Metab 2020;105(3).

(19) Jaafar R, Tran S, Shah AN, Sun G, Valdearcos M, Marchetti P, et al. MTORC1-to-AMPK switching underlies βcell metabolic plasticity during maturation and diabetes. J Clin Invest 2019;129(10):4124-4137.

(20) Mandelbaum AD, Kredo-Russo S, Aronowitz D, Myers N, Yanowski E, Klochendler A, et al. miR-17-92 and miR-106b-25 clusters regulate beta cell mitotic checkpoint and insulin secretion in mice. Diabetologia 2019;62(9):1653-1666.

(21) Borghesan M, Fafián-Labora J, Eleftheriadou O, Carpintero-Fernández P, Paez-Ribes M, Vizcay-Barrena G, et al. Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3. Cell Rep 2019;27(13):3956-3971.e6.

(22) Shemer R, Magenheim J, Dor Y. Digital Droplet PCR for Monitoring Tissue-Specific Cell Death Using DNA Methylation Patterns of Circulating Cell-Free DNA. Curr Protoc Mol Biol 2019;127(1).

(23) Moss J, Magenheim J, Neiman D, Zemmour H, Loyfer N, Korach A, et al. Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease. Nat Commun 2018;9(1).

(24) Sakikubo M, Furuyama K, Horiguchi M, Hosokawa S, Aoyama Y, Tsuboi K, et al. Ptf1a inactivation in adult pancreatic acinar cells causes apoptosis through activation of the endoplasmic reticulum stress pathway. Sci Rep 2018;8(1).

(25) Zemmour H, Planer D, Magenheim J, Moss J, Neiman D, Gilon D, et al. Non-invasive detection of human cardiomyocyte death using methylation patterns of circulating DNA. Nat Commun 2018;9(1).

(26) Riahi Y, Israeli T, Yeroslaviz R, Chimenez S, Avrahami D, Stolovich-Rain M, et al. Inhibition of mTORC1 by ER stress impairs neonatal β-cell expansion and predisposes to diabetes in the Akita mouse. eLife 2018;7.

(27) Horwitz E, Krogvold L, Zhitomirsky S, Swisa A, Fischman M, Lax T, et al. B-cell DNA damage response promotes islet inflammation in type 1 diabetes. Diabetes 2018;67(11):2305-2318.

(28) Dor Y, Cedar H. Principles of DNA methylation and their implications for biology and medicine. Lancet 2018;392(10149):777-786.

(29) Lehmann-Werman R, Magenheim J, Moss J, Neiman D, Abraham O, Piyanzin S, et al. Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA. JCI Insight 2018;3(12).

(30) Anzi S, Stolovich-Rain M, Klochendler A, Fridlich O, Helman A, Paz-Sonnenfeld A, et al. Postnatal Exocrine Pancreas Growth by Cellular Hypertrophy Correlates with a Shorter Lifespan in Mammals. Dev Cell 2018;45(6):726-737.e3.

(31) Gala-Lopez BL, Neiman D, Kin T, O'Gorman D, Pepper AR, Malcolm AJ, et al. Beta Cell Death by Cell-free DNA and Outcome after Clinical Islet Transplantation. Transplantation 2018;102(6):978-985.

(32) Abu-Gazala S, Horwitz E, Schyr RB-, Bardugo A, Israeli H, Hija A, et al. Sleeve gastrectomy improves glycemia independent of weight loss by restoring hepatic insulin sensitivity. Diabetes 2018;67(6):1079-1085.

(33) Neiman D, Moss J, Hecht M, Magenheim J, Piyanzin S, Shapiro AMJ, et al. Islet cells share promoter hypomethylation independently of expression, but exhibit cell-type-specific methylation in enhancers. Proc Natl Acad Sci U S A 2017;114(51):13525-13530.

(34) Swisa A, Kaestner KH, Dor Y. Transcriptional Noise and Somatic Mutations in the Aging Pancreas. Cell Metab 2017;26(6):809-811.

(35) Jäkel C, Bergmann F, Toth R, Assenov Y, Van Der Duin D, Strobel O, et al. Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability. Nat Commun 2017;8(1).

(36) Avrahami D, Wang YJ, Klochendler A, Dor Y, Glaser B, Kaestner KH. β-Cells are not uniform after all—Novel insights into molecular heterogeneity of insulin-secreting cells. Diabetes Obes Metab 2017;19:147-152.

(37) Avrahami D, Klochendler A, Dor Y, Glaser B. Beta cell heterogeneity: an evolving concept. Diabetologia 2017;60(8):1363-1369.

(38) Staels W, Heremans Y, Leuckx G, Van Gassen N, Salinno C, De Groef S, et al. Conditional islet hypovascularisation does not preclude beta cell expansion during pregnancy in mice. Diabetologia 2017;60(6):1051-1056.

(39) Swisa A, Glaser B, Dor Y. Metabolic stress and compromised identity of pancreatic beta cells. Front Genet 2017;8(FEB).

(40) Dahan T, Ziv O, Horwitz E, Zemmour H, Lavi J, Swisa A, et al. Pancreatic β-Cells express the fetal islet hormone gastrin in rodent and human diabetes. Diabetes 2017;66(2):426-436.

(41) Swisa A, Avrahami D, Eden N, Zhang J, Feleke E, Dahan T, et al. PAX6 maintains β cell identity by repressing genes of alternative islet cell types. J Clin Invest 2017;127(1):230-243.

(42) Azizoglu DB, Chong DC, Villasenor A, Magenheim J, Barry DM, Lee S, et al. Vascular development in the vertebrate pancreas. Dev Biol 2016;420(1):67-78.

(43) Brereton MF, Rohm M, Shimomura K, Holland C, Tornovsky-Babeay S, Dadon D, et al. Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells. Nat Commun 2016;7.

(44) He Z, Grunewald M, Dor Y, Keshet E. VEGF regulates relative allocation of Isl1+ cardiac progenitors to myocardial and endocardial lineages. Mech Dev 2016;142:40-49.

(45) Karin O, Swisa A, Glaser B, Dor Y, Alon U. Dynamical compensation in physiological circuits. Mol Syst Biol 2016;12(11).

(46) Helman A, Avrahami D, Klochendler A, Glaser B, Kaestner KH, Ben-Porath I, et al. Effects of ageing and senescence on pancreatic β-cell function. Diabetes Obes Metab 2016;18:58-62.

(47) Malakar P, Chartarifsky L, Hija A, Leibowitz G, Glaser B, Dor Y, et al. Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival. Sci Rep 2016;6.

(48) Klochendler A, Caspi I, Corem N, Moran M, Friedlich O, Elgavish S, et al. The genetic program of pancreatic β-cell replication in vivo. Diabetes 2016;65(7):2081-2093.

(49) Hashimshony T, Senderovich N, Avital G, Klochendler A, de Leeuw Y, Anavy L, et al. CEL-Seq2: Sensitive highly-multiplexed single-cell RNA-Seq. Genome Biol 2016;17(1).

(50) Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, et al. p16 Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion. Nat Med 2016;22(4):412-420.

(51) Lehmann-Werman R, Neiman D, Zemmour H, Moss J, Magenheim J, Vaknin-Dembinsky A, et al. Identification of tissue-specific cell death using methylation patterns of circulating DNA. Proc Natl Acad Sci U S A 2016;113(13):E1826-E1834.

(52) Wittenberg AD, Azar S, Klochendler A, Stolovich-Rain M, Avraham S, Birnbaum L, et al. Phosphorylated ribosomal protein S6 is required for Akt-driven hyperplasia and malignant transformation, but not for hypertrophy, aneuploidy and hyperfunction of pancreatic β-cells. PLoS ONE 2016;11(2).

(53) Swisa A, Granot Z, Tamarina N, Sayers S, Bardeesy N, Philipson L, et al. Loss of liver kinase B1 (LKB1) in beta cells enhances glucose-stimulated insulin secretion despite profound mitochondrial defects. J Biol Chem 2015;290(34):20934-20946.

(54) Stolovich-Rain M, Enk J, Vikesa J, Nielsen FC, Saada A, Glaser B, et al. Erratum to Weaning Triggers a Maturation Step of Pancreatic β Cells [Developmental Cell 32 (2015) 535-545] DOI: 10.1016/j.devcel.2015.04.003. Dev Cell 2015;33(2):238-239.

(55) Stolovich-Rain M, Enk J, Vikesa J, Nielsen F, Saada A, Glaser B, et al. Weaning Triggers a Maturation Step of Pancreatic β Cells. Dev Cell 2015;32(5):535-545.

(56) Kone M, Pullen TJ, Sun G, Ibberson M, Martinez-Sanchez A, Sayers S, et al. LKB1 and AMPK differentially regulate pancreatic β-cell identity. FASEB J 2014;28(11):4972-4985.

(57) Chen Y-, Finkbeiner SR, Weinblatt D, Emmett MJ, Tameire F, Yousefi M, et al. De Novo Formation of Insulin-Producing "Neo-β Cell Islets" from Intestinal Crypts. Cell Rep 2014;6(6):1046-1058.

(58) Hija A, Salpeter S, Klochendler A, Grimsby J, Brandeis M, Glaser B, et al. G0-G1 transition and the restriction point in pancreatic β-cells in vivo. Diabetes 2014;63(2):578-584.

(59) Tornovsky-Babeay S, Dadon D, Ziv O, Tzipilevich E, Kadosh T, Schyr-Ben Haroush R, et al. Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells. Cell Metab 2014;19(1):109-121.

(60) Dor Y, Melton DA. Pancreatic Stem Cells. Essentials of Stem Cell Biology: Third Edition; 2014. p. 329-342.

(61) Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, et al. Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Nat Biotechnol 2014;32(1):76-83.

(62) De Leu N, Heremans Y, Coppens V, Van Gassen N, Cai Y, D'Hoker J, et al. Short-term overexpression of VEGF-A in mouse beta cells indirectly stimulates their proliferation and protects against diabetes. Diabetologia 2014;57(1):140-147.

(63) D'Hoker J, De Leu N, Heremans Y, Baeyens L, Minami K, Ying C, et al. Conditional hypovascularization and hypoxia in islets do not overtly influence adult b-cell mass or function. Diabetes 2013;62(12):4165-4173.

(64) Wikstrom JD, Israeli T, Bachar-Wikstrom E, Swisa A, Ariav Y, Waiss M, et al. AMPK regulates ER morphology and function in stressed pancreatic β-cells via phosphorylation of DRP1. Mol Endocrinol 2013;27(10):1706-1723.

(65) Salpeter SJ, Khalaileh A, Weinberg-Corem N, Ziv O, Glaser B, Dor Y. Erratum: Systemic regulation of the age-related decline of pancreatic β-cell replication (Diabetes (2013) 62 (2843-2848). Diabetes 2013;62(9):3300.

(66) Gur C, Enk J, Weitman E, Bachar E, Suissa Y, Cohen G, et al. The Expression of the Beta Cell-Derived Autoimmune Ligand for the Killer Receptor Nkp46 Is Attenuated in Type 2 Diabetes. PLoS ONE 2013;8(8).

(67) Dor Y, Melton DA. Pancreatic Stem Cells. Handbook of Stem Cells; 2013. p. 819-826.

(68) Suissa Y, Magenheim J, Stolovich-Rain M, Hija A, Collombat P, Mansouri A, et al. Gastrin: A Distinct Fate of Neurogenin3 Positive Progenitor Cells in the Embryonic Pancreas. PLoS ONE 2013;8(8).

(69) Salpeter SJ, Khalaileh A, Weinberg-Corem N, Ziv O, Glaser B, Dor Y. Systemic regulation of the age-Related decline of pancreatic β-Cell replication. Diabetes 2013;62(8):2843-2848.

(70) Ziv O, Glaser B, Dor Y. The plastic pancreas. Dev Cell 2013;26(1):3-7.

(71) Khalaileh A, Dreazen A, Khatib A, Apel R, Swisa A, Kidess-Bassir N, et al. Phosphorylation of ribosomal protein S6 attenuates DNA damage and tumor suppression during development of pancreatic cancer. Cancer Res 2013;73(6):1811-1820.

(72) Van De Casteele M, Leuckx G, Baeyens L, Cai Y, Yuchi Y, Coppens V, et al. Neurogenin 3+ cells contribute to b-cell neogenesis and proliferation in injured adult mouse pancreas. Cell Death Dis 2013;4(3).

(73) Dor Y, Glaser B. Beta-cell dedifferentiation and type 2 diabetes. New Engl J Med 2013;368(6):572-573.

(74) Boj SF, Van Es JH, Huch M, Li VSW, José A, Hatzis P, et al. Diabetes risk gene and wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell 2012;151(7):1595-1607.

(75) Prévot P-, Simion A, Grimont A, Colletti M, Khalaileh A, Van Den Steen G, et al. Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia. Gut 2012;61(12):1723-1732.

(76) Klochendler A, Weinberg-Corem N, Moran M, Swisa A, Pochet N, Savova V, et al. A Transgenic Mouse Marking Live Replicating Cells Reveals In Vivo Transcriptional Program of Proliferation. Dev Cell 2012;23(4):681-690.

(77) Mandelbaum AD, Melkman-Zehavi T, Oren R, Kredo-Russo S, Nir T, Dor Y, et al. Dysregulation of Dicer1 in beta cells impairs islet architecture and glucose metabolism. Exp Dia Res 2012;2012.

(78) Cleaver O, Dor Y. Vascular instruction of pancreas development. Development 2012;139(16):2833-2843.

(79) Stolovich-Rain M, Hija A, Grimsby J, Glaser B, Dor Y. Pancreatic beta cells in very old mice retain capacity for compensatory proliferation. J Biol Chem 2012;287(33):27407-27414.

(80) Kaufman-Francis K, Koffler J, Weinberg N, Dor Y, Levenberg S. Engineered vascular beds provide key signals to pancreatic hormone-producing cells. PLoS ONE 2012;7(7).

(81) Dadon D, Tornovsky-Babaey S, Furth-Lavi J, Ben-Zvi D, Ziv O, Schyr-Ben-Haroush R, et al. Glucose metabolism: Key endogenous regulator of β-cell replication and survival. Diabetes Obes Metab 2012;14(SUPPL.3):101-108.

(82) Magenheim J, Ilovich O, Lazarus A, Klochendler A, Ziv O, Werman R, et al. Blood vessels restrain pancreas branching, differentiation and growth. Development (Cambridge) 2011;138(21):4743-4752.

(83) Gur C, Enk J, Kassem SA, Suissa Y, Magenheim J, Stolovich-Rain M, et al. Recognition and killing of human and murine pancreatic β cells by the NK receptor NKp46. J Immunol 2011;187(6):3096-3103.

(84) Salpeter SJ, Klochendler A, Weinberg-Corem N, Porat S, Granot Z, Shapiro AMJ, et al. Glucose regulates cyclin D2 expression in quiescent and replicating pancreatic β-cells through glycolysis and calcium channels. Endocrinology 2011;152(7):2589-2598.

(85) Porat S, Weinberg-Corem N, Tornovsky-Babaey S, Schyr-Ben-Haroush R, Hija A, Stolovich-Rain M, et al. Control of pancreatic β cell regeneration by glucose metabolism. Cell Metab 2011;13(4):440-449.

(86) Melkman-Zehavi T, Oren R, Kredo-Russo S, Shapira T, Mandelbaum AD, Rivkin N, et al. MiRNAs control insulin content in pancreatic β 2-cells via downregulation of transcriptional repressors. EMBO J 2011;30(5):835-845.

(87) Magenheim J, Klein AM, Stanger BZ, Ashery-Padan R, Sosa-Pineda B, Gu G, et al. Ngn3+ endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium. Dev Biol 2011;359(1):26-36.

(88) Sand FW, Hörnblad A, Johansson JK, Lorén C, Edsbagge J, Ståhlberg A, et al. Growth-limiting role of endothelial cells in endoderm development. Dev Biol 2011;352(2):267-277.

(89) Schlager A, Khalaileh A, Mintz Y, Gazala MA, Globerman A, Ilani N, et al. A mouse model for sleeve gastrectomy: Applications for diabetes research. Microsurgery 2011;31(1):66-71.

(90) Salpeter SJ, Klein AM, Huangfu D, Grimsby J, Dor Y. Glucose and aging control the quiescence period that follows pancreatic beta cell replication. Development (Cambridge) 2010;137(19):3205-3213.

(91) Gur C, Porgador A, Elboim M, Gazit R, Mizrahi S, Stern-Ginossar N, et al. The activating receptor NKp46 is essential for the development of type 1 diabetes. Nat Immunol 2010;11(2):121-128.

(92) Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, et al. The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α. Cell 2010;140(2):280-293.

(93) Dor Y, Melton DA. Pancreatic Stem Cells. Essentials of Stem Cell Biology; 2009. p. 299-305.

(94) Granot Z, Swisa A, Magenheim J, Stolovich-Rain M, Fujimoto W, Manduchi E, et al. LKB1 Regulates Pancreatic β Cell Size, Polarity, and Function. Cell Metab 2009;10(4):296-308.

(95) Wang S, Jensen JN, Seymour PA, Hsu W, Dor Y, Sander M, et al. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A 2009;106(24):9715-9720.

(96) Setty Y, Cohen IR, Dor Y, Harel D. Four-dimensional realistic modeling of pancreatic organogenesis. Proc Natl Acad Sci U S A 2008;105(51):20374-20379.

(97) Salpeter SJ, Dor Y. Beta-cell replication. Pancreatic Beta Cell in Health and Disease; 2008. p. 245-263.

(98) Wang S, Hecksher-Sorensen J, Xu Y, Zhao A, Dor Y, Rosenberg L, et al. Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation. Dev Biol 2008;317(2):531-540.

(99) Wasserstrom A, Frumkin D, Adar R, Itzkovitz S, Stern T, Kaplan S, et al. Estimating cell depth from somatic mutations. PLoS Comput Biol 2008;4(5).

(100) Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, et al. Pancreatic Lkb1 deletion leads to acinar polarity defects and cystic neoplasms. Mol Cell Biol 2008;28(7):2414-2425.

(101) Dor Y, Melton DA. Facultative Endocrine Progenitor Cells in the Adult Pancreas. Cell 2008;132(2):183-184.

(102) Khalaileh A, Gonen-gross T, Magenheim J, Nir T, Porat S, Salpeter S, et al. Determinants of pancreatic β-cell regeneration. Diabetes Obes Metab 2008;10(SUPPL. 4):128-135.

(103) Fendrich V, Esni F, Garay MVR, Feldmann G, Habbe N, Jensen JN, et al. Hedgehog Signaling Is Required for Effective Regeneration of Exocrine Pancreas. Gastroenterology 2008;135(2):621-631.e8.

(104) Nir T, Melton DA, Dor Y. Recovery from diabetes in mice by β cell regeneration. J Clin Invest 2007;117(9):2553-2561.

(105) Porat S, Dor Y. New sources of pancreatic beta cells. Curr Diabetes Rep 2007;7(4):304-308.

(106) Weinberg N, Ouziel-Yahalom L, Knoller S, Efrat S, Dor Y. Lineage tracing evidence for in vitro dedifferentiation but rare proliferation of mouse pancreatic β-cells. Diabetes 2007;56(5):1299-1304.

(107) Strobel O, Dor Y, Stirman A, Trainor A, Fernández-del Castillo C, Warshaw AL, et al. β cell transdifferentiation does not contribute to preneoplastic/metaplastic ductal lesions of the pancreas by genetic lineage tracing in vivo. Proc Natl Acad Sci U S A 2007;104(11):4419-4424.

(108) Dor Y, Stanger BZ. Regeneration in liver and pancreas: time to cut the umbilical cord? Sci STKE 2007;2007(414).

(109) Strobel O, Dor Y, Alsina J, Stirman A, Lauwers G, Trainor A, et al. In Vivo Lineage Tracing Defines the Role of Acinar-to-Ductal Transdifferentiation in Inflammatory Ductal Metaplasia. Gastroenterology 2007;133(6):1999-2009.

(110) Grunewald M, Avraham I, Dor Y, Bachar-Lustig E, Itin A, Yung S, et al. VEGF-Induced Adult Neovascularization: Recruitment, Retention, and Role of Accessory Cells (DOI:10.1016/j.cell.2005.10.036). Cell 2006;126(4):811.

(111) Dor Y. β-cell proliferation is the major source of new pancreatic β cells. Nat Clin Pract Endocrinol Metab 2006;2(5):242-243.

(112) Grunewald M, Avraham I, Dor Y, Bachar-Lustig E, Itin A, Yung S, et al. VEGF-induced adult neovascularization: Recruitment, retention, and role of accessory cells. Cell 2006;124(1):175-189.

(113) Salpeter SJ, Dor Y. Pancreatic Cells and Their Progenitors. Methods Enzymol 2006;419:322-337.

(114) Stanger BZ, Dor Y. Dissecting the cellular origins of pancreatic cancer. Cell Cycle 2006;5(1):43-46.

(115) Murtaugh LC, Law AC, Dor Y, Melton DA. β-Catenin is essential for pancreatic acinar but not islet development. Development (Cambridge) 2005;132(21):4663-4674.

(116) Nir T, Dor Y. How to make pancreatic β cells - Prospects for cell therapy in diabetes. Curr Opin Biotechnol 2005;16(5):524-529.

(117) Ruvinsky I, Sharon N, Lerer T, Cohen H, Stolovich-Rain M, Nir T, et al. Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev 2005;19(18):2199-2211.

(118) Karni R, Gus Y, Dor Y, Meyuhas O, Levitzki A. Active Src elevates the expression of β-catenin by enhancement of cap-dependent translation. Mol Cell Biol 2005;25(12):5031-5039.

(119) Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, et al. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell 2005;8(3):185-195.

(120) Dor Y, Melton DA. Pancreatic Stem Cells. Handbook of Stem Cells; 2004. p. 513-520.

(121) Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004;429(6987):41-46.

(122) Dor Y, Melton DA. How important are adult stem cells for tissue maintenance? Cell Cycle 2004;3(9):1102-1104.

(123) Dor Y, Klewer SE, McDonald JA, Keshet E, Camenisch TD. VEGF modulates early heart valve formation. Anat Rec Part A Discov Mol Cell Evol Biol 2003;271(1):202-208.

(124) Dor Y, Djonov V, Keshet E. Making vascular networks in the adult: Branching morphogenesis without a roadmap. Trends Cell Biol 2003;13(3):131-136.

(125) Dor Y, Djonov V, Keshet E. Induction of vascular networks in adult organs: Implications to proangiogenic therapy. Ann New York Acad Sci 2003;995:208-216.

(126) Karni R, Dor Y, Keshet E, Meyuhas O, Levitzki A. Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1α expression under normoxia. J Biol Chem 2002;277(45):42919-42925.

(127) Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, et al. Erratum: Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice (Nature Medicine (2002) 8 (702-710)). Nat Med 2002;8(11):1329.

(128) Dor Y, Djonov V, Abramovitch R, Itin A, Fishman GI, Carmeliet P, et al. Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy. EMBO J 2002;21(8):1939-1947.

(129) Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, et al. Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med 2002;8(7):702-710.

(130) Brusselmans K, Bono F, Maxwell P, Dor Y, Dewerchin M, Collen D, et al. Hypoxia-inducible Factor-2α (HIF-2α) Is Involved in the Apoptotic Response to Hypoglycemia but Not to Hypoxia. J Biol Chem 2001;276(42):39192-39196.

(131) Dor Y, Camenisch TD, Itin A, Fishman GI, McDonald JA, Carmeliet P, et al. A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects. Development (Cambridge) 2001;128(9):1531-1538.

(132) Dor Y, Porat R, Keshet E. Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis. Am J Physiol Cell Physiol 2001;280(6 49-6):C1367-C1374.

(133) Raboy B, Marom A, Dor Y, Kulka RG. Heat-induced cell cycle arrest of Saccharomyces cerevisiae: Involvement of the RAD6/UBC2 and WSC2 genes in its reversal. Mol Microbiol 1999;32(4):729-739.

(134) Carmeliet P, Dor Y, Herbert J-, Fukumura D, Brusselmans K, Dewerchin M, et al. Erratum: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (Nature (1998) 394 (485-490)). Nature 1998;395(6701):525.

(135) Carmeliet P, Dor Y, Herber J-, Fukumura D, Brusselmans K, Dewerchin M, et al. Role of HIF-1α in hypoxiamediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998;394(6692):485-490.

(136) Dor Y, Keshet E. Ischemia-driven angiogenesis. Trends Cardiovasc Med 1997;7(8):289-294.

(137) Dor Y, Raboy B, Kulka RG. Role of the conserved carboxy-terminal α-helix of Rad6p in ubiquitination and DNA repair. Mol Microbiol 1996;21(6):1197-1206.