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The Faculty of Medicine - Developmental Biology and Cancer Research: Fainsod Abraham


 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Leibovich A, Edri T, Klein SL, Moody SA, Fainsod A. Natural size variation among embryos leads to the corresponding scaling in gene expression. Dev Biol 2020;462(2):165-179.

(2) Fainsod A, Bendelac-Kapon L, Shabtai Y. Fetal Alcohol Spectrum Disorder: Embryogenesis Under Reduced Retinoic Acid Signaling Conditions. Sub-Cell Biochem 2020;95:197-225.

(3) Shukrun N, Shabtai Y, Pillemer G, Fainsod A. Retinoic acid signaling reduction recapitulates the effects of alcohol on embryo size. Genesis 2019;57(7).

(4) Petrelli B, Bendelac L, Hicks GG, Fainsod A. Insights into retinoic acid deficiency and the induction of craniofacial malformations and microcephaly in fetal alcohol spectrum disorder. Genesis 2019;57(1).

(5) Shabtai Y, Bendelac L, Jubran H, Hirschberg J, Fainsod A. Acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity. Sci Rep 2018;8(1).

(6) Leibovich A, Kot-Leibovich H, Ben-Zvi D, Fainsod A. ADMP controls the size of Spemann's organizer through a network of self-regulating expansion-restriction signals. BMC Biol 2018;16(1).

(7) Fainsod A, Kot-Leibovich H. Xenopus embryos to study fetal alcohol syndrome, a model for environmental teratogenesis. Biochem Cell Biol 2018;96(2):77-87.

(8) Fainsod A, Hicks G. Special issue on fetal alcohol spectrum disorder. Biochem Cell Biol 2018;96(2):v-vi.

(9) Shabtai Y, Fainsod A. Competition between ethanol clearance and retinoic acid biosynthesis in the induction of fetal alcohol syndrome. Biochem Cell Biol 2018;96(2):148-160.

(10) Ulmer B, Tingler M, Kurz S, Maerker M, Andre P, Mönch D, et al. A novel role of the organizer gene Goosecoid as an inhibitor of Wnt/PCP-mediated convergent extension in Xenopus and mouse. Sci Rep 2017;7.

(11) Leibovich A, Steinbeißer H, Fainsod A. Expression of the ALK1 family of type I BMP/ADMP receptors during gastrula stages in Xenopus embryos. Int J Dev Biol 2017;61(6-7):465-470.

(12) Shabtai Y, Shukrun N, Fainsod A. ADHFe1: A novel enzyme involved in retinoic acid-dependent Hox activation. Int J Dev Biol 2017;61(3-5):303-310.

(13) Gur M, Cohen EB-, Genin O, Fainsod A, Perles Z, Cinnamon Y. Roles of the cilium-associated gene CCDC11 in left–right patterning and in laterality disorders in humans. Int J Dev Biol 2017;61(3-5):267-276.

(14) Shabtai Y, Jubran H, Nassar T, Hirschberg J, Fainsod A. Kinetic characterization and regulation of the human retinaldehyde dehydrogenase 2 enzyme during production of retinoic acid. Biochem J 2016;473(10):1423-1431.

(15) Vitorino M, Silva AC, Inácio JM, Ramalho JS, Gur M, Fainsod A, et al. Xenopus Pkdcc1 and Pkdcc2 are two new tyrosine kinases involved in the regulation of JNK dependent Wnt/PCP signaling pathway. PLoS ONE 2015;10(8).

(16) Feine O, Hukasova E, Bruinsma W, Freire R, Fainsod A, Gannon J, et al. Phosphorylation-mediated stabilization of bora in mitosis coordinates Plx1/Plk1 and Cdk1 oscillations. Cell Cycle 2014;13(11):1727-1736.

(17) Ben-Zvi D, Fainsod A, Shilo B-, Barkai N. Scaling of dorsal-ventral patterning in the Xenopus laevis embryo. Bioessays 2014;36(2):151-156.

(18) Schyr RB-, Shabtai Y, Shashikant CS, Fainsod A. Cdx1 is essential for the initiation of HoxC8 expression during early embryogenesis. FASEB J 2012;26(6):2674-2684.

(19) Sharon N, Mor I, Golan-Lev T, Fainsod A, Benvenisty N. Molecular and functional characterizations of gastrula organizer cells derived from human embryonic stem cells. Stem Cells 2011;29(4):600-608.

(20) Rousso SZ, Schyr RB-, Gur M, Zouela N, Kot-Leibovich H, Shabtai Y, et al. Negative autoregulation of Oct3/4 through Cdx1 promotes the onset of gastrulation. Dev Dyn 2011;240(4):796-807.

(21) Abu-Remaileh M, Gerson A, Farago M, Nathan G, Alkalay I, Zins Rousso S, et al. Oct-3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/β-catenin signalling. EMBO J 2010;29(19):3236-3248.

(22) Ben-Zvi D, Shilo B-, Fainsod A, Barkai N. Reply to Francois et al. Nature 2009;461(7260):E2-E3.

(23) Kot-Leibovich H, Fainsod A. Ethanol induces embryonic malformations by competing for retinaldehyde dehydrogenase activity during vertebrate gastrulation. DNM Dis Models Mech 2009;2(5-6):295-305.

(24) Ben-Zvi D, Shilo B-, Fainsod A, Barkai N. Scaling of the BMP activation gradient in Xenopus embryos. Nature 2008;453(7199):1205-1211.

(25) Yelin R, Kot H, Yelin D, Fainsod A. Early molecular effects of ethanol during vertebrate embryogenesis. Differentiation 2007;75(5):393-403.

(26) Marom K, Levy V, Pillemer G, Fainsod A. Temporal analysis of the early BMP functions identifies distinct anti-organizer and mesoderm patterning phases. Dev Biol 2005;282(2):442-454.

(27) Yelin R, Schyr RB-, Kot H, Zins S, Frumkin A, Pillemer G, et al. Ethanol exposure affects gene expression in the embryonic organizer and reduces retinoic acid levels. Dev Biol 2005;279(1):193-204.

(28) Traister A, Abashidze S, Gold V, Yairi R, Michael E, Plachta N, et al. BMP controls nitric oxide-mediated regulation of cell numbers in the developing neural tube. Cell Death Differ 2004;11(8):832-841.

(29) Yaniv K, Fainsod A, Kalcheim C, Yisraeli JK. The RNA-binding protein Vg1 RBP is required for cell migration during early neural development. Development (Cambridge) 2003;130(23):5649-5661.

(30) Hershko AY, Kafri T, Fainsod A, Razin A. Methylation of HoxA5 and HoxB5 and its relevance to expression during mouse development. Gene 2003;302(1-2):65-72.

(31) Tour E, Pillemer G, Gruenbaum Y, Fainsod A. Gbx2 interacts with Otx2 and patterns the anterior-posterior axis during gastrulation in Xenopus. Mech Dev 2002;112(1-2):141-151.

(32) Tour E, Pillemer G, Gruenbaum Y, Fainsod A. Otx2 can activate the isthmic organizer genetic network in the Xenopus embryo. Mech Dev 2002;110(1-2):3-13.

(33) Levy V, Marom K, Zins S, Koutsia N, Yelin R, Fainsod A. The competence of marginal zone cells to become Spemann’s organizer is controlled by Xcad2. Dev Biol 2002;248(1):40-51.

(34) Tour E, Pillemer G, Gruenbaum Y, Fainsod A. The two Xenopus Gbx2 genes exhibit similar, but not identical expression patterns and can affect head formation. FEBS Lett 2001;507(2):205-209.

(35) Shapira E, Marom K, Levy V, Yelin R, Fainsod A. The Xvex-1 antimorph reveals the temporal competence for organizer formation and an early role for ventral homeobox genes. Mech Dev 2000;90(1):77-87.

(36) Marom K, Fainsod A, Steinbeisser H. Patterning of the mesoderm involves several threshold responses to BMP-4 and Xwnt-8. Mech Dev 1999;87(1-2):33-44.

(37) Shapira E, Marom K, Yelin R, Levy A, Fainsod A. A role for the homeobox gene Xvex-1 as part of the BMP-4 ventral signaling pathway. Mech Dev 1999;86(1-2):99-111.

(38) Pillemer G, Yelin R, Epstein M, Gont L, Frumkin Y, Yisraeli JK, et al. The Xcad-2 gene can provide a ventral signal independent of BMP-4. Mech Dev 1998;74(1-2):133-143.

(39) Pillemer G, Epstein M, Blumberg B, Yisraeli JK, De Robertis EM, Steinbeisser H, et al. Nested expression and sequential downregulation of the Xenopus caudal genes along the anterior-posterior axis. Mech Dev 1998;71(1-2):193-196.

(40) Epstein M, Pillemer G, Yelin R, Yisraeli JK, Fainsod A. Patterning of the embryo along the anterior-posterior axis: The role of the caudal genes. Development 1997;124(19):3805-3814.

(41) Marom K, Shapira E, Fainsod A. The chicken caudal genes establish an anterior-posterior gradient by partially overlapping temporal and spatial patterns of expression. Mech Dev 1997;64(1-2):41-52.

(42) Fainsod A, Deißler K, Yelin R, Marom K, Epstein M, Pillemer G, et al. The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4. Mech Dev 1997;63(1):39-50.

(43) Gont LK, Fainsod A, Kim S-, De Robertis EM. Overexpression of the homeobox gene Xnot-2 leads to notochord formation in Xenopus. Dev Biol 1996;174(1):174-178.

(44) Schubert FR, Fainsod A, Gruenbaum Y, Gruss P. Expression of the novel murine homeobox gene Sax-1 in the developing nervous system. Mech Dev 1995;51(1):99-114.

(45) Steinbeisser H, Fainsod A, Niehrs C, Sasai Y, De Robertis EM. The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: a loss-of-function study using antisense RNA. EMBO J 1995;14(21):5230-5243.

(46) Khatib H, Berkovitz D, Ratz T, Plotzki Y, Fainsod A, Gruenbaum Y. Mapping the CdxA gene to a new linkage group in chicken. Anim Genet 1995;26(3):211-211.

(47) DeRobertis EM, Fainsod A, Gont LK, Steinbeisser H. The evolution of vertebrate gastrulation. Development 1994;120(SUPPL.):117-124.

(48) Frumkin A, Pillemer G, Haffner R, Tarcic N, Gruenbaum Y, Fainsod A. A role for CdxA in gut closure and intestinal epithelia differentiation. Development 1994;120(2):253-263.

(49) Fainsod A, Steinbeisser H, De Robertis EM. On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo. EMBO J 1994;13(21):5015-5025.

(50) Spann P, Ginsburg M, Rangini Z, Fainsod A, Eyal-Giladi H, Gruenbaum Y. The spatial and temporal-dynanamics of Sax1 (CHox3) homeobox gene expression in the chick's spinal cord. Development 1994;120(7):1817-1828.

(51) Margalit Y, Yarus S, Shapira E, Gruenbaum Y, Fainsod A. Isolation and characterization of target sequences of the chicken CdxA homeobox gene. Nucleic Acids Res 1993;21(21):4915-4922.

(52) Frumkin A, Haffner R, Shapira E, Tarcic N, Gruenbaum Y, Fainsod A. The chicken CdxA homeobox gene and axial positioning during gastrulation. Development 1993;118(2):553-562.

(53) Iraqi F, Khatib H, Shani G, Davarsi A, Frumkin A, Zeitlin G, et al. CHox‐cad locus may influence quantitative traits in chickens. J Exp Zool 1992;263(3):303-308.

(54) Fainsod A, Margalit Y, Haffner R, Gruenbaum Y. Non-immunological precipitation of protein-DNA complexes using glutathione-S-transferase fusion proteins. Nucleic Acids Res 1991;19(14):4005.

(55) Frumkin A, Rangini Z, Ben-Yehuda A, Gruenbaum Y, Fainsod A. A chicken caudal homologue, CHox-cad, expressed in the epiblast with posterior localization and in the early endodermal lineage. Development 1991;112(1):207-219.

(56) Shapira E, Yarus S, Fainsod A. Genomic organization and expression during embryogenesis of the chicken CR1 repeat. Genomics 1991;10(4):931-939.

(57) Rangini Z, Ben-Yehuda A, Shapira E, Gruenbaum Y, Fainsod A. CHox E, a chicken homeogene of the H2.0 type exhibits dorso-ventral restriction in the proliferating region of the spinal cord. Mech Dev 1991;35(1):13-24.

(58) Padan R, Nainudal-Epszteyn S, Goitein R, Fainsod A, Gruenbaum Y. Isolation and characterization of the Drosophila nuclear envelope otefin cDNA. J Biol Chem 1990;265(14):7808-7813.

(59) Renbaum P, Abrahamove D, Fainsod A, Wilson GG, Rottem S, Razin A. Cloning, characterization, and expression in Escherichia coli of the gene coding for the CpG DNA methylase from Spiroplasma sp. strain MQ1(M Sssl). Nucleic Acids Res 1990;18(5):1145-1152.

(60) Osman M, Paz M, Landesman Y, Fainsod A, Gruenbaum Y. Molecular analysis of the Drosophila nuclear lamin gene. Genomics 1990;8(2):217-224.

(61) Fainsod A, Gruenbaum Y. A chicken homeo box gene with developmentally regulated expression. FEBS Lett 1989;250(2):381-385.

(62) Rangini Z, Frumkin A, Shani G, Guttmann M, Eyal-Giladi H, Gruenbaum Y, et al. The chicken homeo box genes CHox1 and CHox3: cloning, sequencing and expression during embryogenesis. Gene 1989;76(1):61-74.

(63) Hart CP, Bogarad LD, Fainsod A, Ruddle FH. Polypurine/polypyrimidine sequence elements of the murine homeo box loci, Hox-1, -2 and -3. Nucleic Acids Res 1987;15(13):5495.

(64) Fainsod A, Awgulewitsch A, Ruddle FH. Expression of the murine homeo box gene Hox 1.5 during embryogenesis. Dev Biol 1987;124(1):125-133.

(65) Hart CP, Fainsod A, Ruddle FH. Sequence analysis of the murine Hox-2.2, -2.3, and -2.4 homeo boxes: Evolutionary and structural comparisons. Genomics 1987;1(2):182-195.

(66) Fainsod A, Diamond G, Marcus M, Ruddle FH. Cloning of a human S-phase cell cycle gene: Use of transient expression for screening. Mol Cell Biol 1987;7(2):775-779.

(67) Fienberg AA, Utset MF, Ruddle FH, Bogarad LD, Hart CP, Awgulewitsch A, et al. Homeo box genes in murine development. Curr Top Dev Biol 1987;23(C):233-256.

(68) Fainsod A, Bogarad LD, Ruusala T, Lubin M, Crothers DM, Ruddle FH. The homeo domain of a murine protein binds 5' to its own homeo box. Proc Natl Acad Sci U S A 1986;83(24):9532-9536.

(69) Marcus M, Fainsod A, Diamond G. The genetic analysis of mammalian cell-cycle mutants. Annu Rev Genet 1985;19:389-421.

(70) Hart CP, Awgulewitsch A, Fainsod A, McGinnis W, Ruddle FH. Homeo box gene complex on mouse chromosome 11: Molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell 1985;43(1):9-18.

(71) Ruddle FH, Hart CP, Awgulewitsch A, Fainsod A, Utset M, Dalton D, et al. Mammalian homeo box genes. COLD SPRING HARBOR SYMP QUANT BIOL 1985;VOL. 50:277-284.

(72) Fainsod A, Goitein R, Marcus M. Analysis of a Chinese hamster temperature-sensitive cell cycle mutant arrested in early S phase. Exp Cell Res 1984;152(1):77-90.

(73) Fainsod A, Marcus M, Lin PF, Ruddle FH. Partial purification and characterization of the mRNA complementing a temperature-sensitive S-phase cell cycle mutation. Proc Natl Acad Sci U S A 1984;81(8 I):2393-2395.

(74) Fainsod A, Voss R, Spann P, Goitein R, Marcus M. A temperature sensitive mutant of a Chinese hamster cell line exhibiting high chromosomal breakage. Cytogenet Genome Res 1983;35(2):104-109.