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The Faculty of Medicine - Developmental Biology and Cancer Research: Glaser Gadi

Researchers

 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Kaspy I, Glaser G. Escherichia coli RelA Regulation via Its C-Terminal Domain. Front Microbiol 2020;11.

(2) Chevion M, Mager J, Glaser G. Naturally occurring food toxicants: Favismproducing agents. CRC Handbook of Naturally Occurring Food Toxicants; 2018. p. 63-80.

(3) Kaspy I, Rotem E, Weiss N, Ronin I, Balaban NQ, Glaser G. HipA-mediated antibiotic persistence via phosphorylation of the glutamyl-tRNA-synthetase. Nat Commun 2013;4.

(4) Wexselblatt E, Kaspy I, Glaser G, Katzhendler J, Yavin E. Design, synthesis and structure-activity relationship of novel Relacin analogs as inhibitors of Rel proteins. Eur J Med Chem 2013;70:497-504.

(5) Wexselblatt E, Oppenheimer-Shaanan Y, Kaspy I, London N, Schueler-Furman O, Yavin E, et al. Relacin, a Novel Antibacterial Agent Targeting the Stringent Response. PLoS Pathog 2012;8(9).

(6) Wexselblatt E, Katzhendler J, Saleem-Batcha R, Hansen G, Hilgenfeld R, Glaser G, et al. ppGpp analogues inhibit synthetase activity of Rel proteins from Gram-negative and Gram-positive bacteria. Bioorg Med Chem 2010;18(12):4485-4497.

(7) Drobnak I, Korenčič A, Loris R, Marianovsky I, Glaser G, Jamnik A, et al. Energetics of MazG Unfolding in Correlation with Its Structural Features. J Mol Biol 2009;392(1):63-74.

(8) Gross M, Marianovsky I, Glaser G. MazG - A regulator of programmed cell death in Escherichia coli. Mol Microbiol 2006;59(2):590-601.

(9) Lah J, Šimić M, Vesnaver G, Marianovsky I, Glaser G, Engelberg-Kulka H, et al. Energetics of structural transitions of the addiction antitoxin MazE: Is a programmed bacterial cell death dependent on the intrinsically flexible nature of the antitoxins. J Biol Chem 2005;280(17):17397-17407.

(10) Rochman M, Blot N, Dyachenko M, Glaser G, Travers A, Muskhelishvili G. Buffering of stable RNA promoter activity against DNA relaxation requires a far upstream sequence. Mol Microbiol 2004;53(1):143-152.

(11) Loris R, Marianovsky I, Lah J, Laeremans T, Engelberg-Kulka H, Glaser G, et al. Crystal structure of the intrinsically flexible addiction antidote MazE. J Biol Chem 2003;278(30):28252-28257.

(12) Lah J, Marianovsky I, Glaser G, Engelberg-Kulka H, Kinne J, Wyns L, et al. Recognition of the intrinsically flexible addiction antidote MazE by a dromedary single domain antibody fragment: Structure, thermodynamics of binding, stability, and influence on interactions with DNA. J Biol Chem 2003;278(16):14101-14111.

(13) Rochman M, Aviv M, Glaser G, Muskhelishvili G. Promoter protection by a transcription factor acting as a local topological homeostat. EMBO Rep 2002;3(4):355-360.

(14) Sat B, Hazan R, Fisher T, Khaner H, Glaser G, Engelberg-Kulka H. Programmed cell death in Escherichia coli: Some antibiotics can trigger mazEF lethality. J Bacteriol 2001;183(6):2041-2045.

(15) Marianovsky I, Aizenman E, Engelberg-Kulka H, Glaser G. The Regulation of the Escherichia coli mazEF Promoter Involves an Unusual Alternating Palindrome. J Biol Chem 2001;276(8):5975-5984.

(16) Gropp M, Strausz Y, Gross M, Glaser G. Regulation of Escherichia coli RelA requires oligomerization of the C-terminal domain. J Bacteriol 2001;183(2):570-579.

(17) Engelberg-Kulka H, Glaser G. Addiction modules and programmed cell death and antideath in bacterial cultures. Annu Rev Microbiol 1999;53:43-70.

(18) Engelberg-Kulka H, Reches M, Narasimhan S, Schoulaker-Schwarz R, Klemes Y, Aizenman E, et al. rexB of bacteriophage λ is an anti-cell death gene. Proc Natl Acad Sci U S A 1998;95(26):15481-15486.

(19) Aviv M, Giladi H, Oppenheim AB, Glaser G. Analysis of the shut-off of ribosomal RNA promoters in Escherichia coli upon entering the stationary phase of growth. FEMS Microbiol Lett 1996;140(1):71-76.

(20) Aizenman E, Engelberg-Kulka H, Glaser G. An Escherichia coli chromosomal "addiction module" regulated by 3′,5′-bispyrophosphate: A model for programmed bacterial cell death. Proc Natl Acad Sci U S A 1996;93(12):6059-6063.

(21) Aizenman E, Engelberg-Kulka H, Glaser G. Erratum: An Escherichia coli chromosomal 'addiction module' regulated by 3',5'-bispyrophosphate: A model for programmed bacterial cell death (Proceedings of the National Academy of Sciences of the United States of America (June 11, 1996) 93:12 (6059-6063)). Proc Natl Acad Sci U S A 1996;93(18):9991.

(22) Schreiber G, Ron EZ, Glaser G. ppGpp-mediated regulation of DNA replication and cell division in Escherichia coli. Curr Microbiol 1995;30(1):27-32.

(23) Gafny R, Cohen S, Nachaliel N, Glaser G. Isolated P2 rRNA promoters of Escherichia coli are strong promoters that are subject to stringent control. J Mol Biol 1994;243(2):152-156.

(24) Gropp M, Eizenman E, Glaser G, Samarrai W, Rudner R. A relAS suppressor mutant allele of Bacillus subtilis which maps to relA and responds only to carbon limitation. Gene 1994;140(1):91-96.

(25) Aviv M, Giladi H, Schreiber G, Oppenheim AB, Glaser G. Expression of the genes coding for the Escherichia coli integration host factor are controlled by growth phase, rpoS, ppGpp and by autoregulation. Mol Microbiol 1994;14(5):1021-1031.

(26) Jones PG, Cashel M, Glaser G, Neidhardt FC. Function of a relaxed-like state following temperature downshifts in Escherichia coli. J Bacteriol 1992;174(12):3903-3914.

(27) Rahav-Manor O, Carmel O, Karpel R, Taglicht D, Glaser G, Schuldiner S, et al. NhaR, a protein homologous to a family of bacterial regulatory proteins (LysR), regulates nhaA, the sodium proton antiporter gene in Escherichia coli. J Biol Chem 1992;267(15):10433-10438.

(28) Xiao H, Kalman M, Ikehara K, Zemel S, Glaser G, Cashel M. Residual guanosine 3',5'-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations. J Biol Chem 1991;266(9):5980-5990.

(29) Schreiber G, Metzger S, Aizenman E, Roza S, Cashel M, Glaser G. Overexpression of the relA gene in Escherichia coli. J Biol Chem 1991;266(6):3760-3767.

(30) Karpel R, Alon T, Glaser G, Schuldiner S, Padan E. Expression of a sodium proton antiporter (NhaA) in Escherichia coli is induced by Na+ and Li+ ions. J Biol Chem 1991;266(32):21753-21759.

(31) Nachaliel N, Melnick J, Gafny R, Glaser G. Ribosome associated protein(s) specifically bind(s) to the upstream activator sequence of the E. coli rrnA P1 promoter. Nucleic Acids Res 1989;17(23):9811-9822.

(32) Metzger S, Schreiber G, Aizenman E, Cashel M, Glaser G. Characterization of the relA1 mutation and a comparison of relA1 with new relA null alleles in Escherichia coli. J Biol Chem 1989;264(35):21146-21152.

(33) Gross SR, Levine PH, Metzger S, Glaser G. Recombination and replication of plasmid-like derivatives of a short section of the mitochondrial chromosome of Neurospora crassa. Genetics 1989;121(4):693-701.

(34) Metzger S, Sarubbi E, Glaser G, Cashel M. Protein sequences encoded by the relA and the spoT genes of Escherichia coli are interrelated. J Biol Chem 1989;264(16):9122-9125.

(35) Gafny R, Hyman HC, Razin S, Glaser G. Promoters of Mycoplasma capricolum ribosomal RNA operons: Identical activities but different regulation in homologous and heterologous cells. Nucleic Acids Res 1988;16(1):61-76.

(36) Hyman HC, Gafny R, Glaser G, Razin S. Promoter of the Mycoplasma pneumoniae rRNA operon. J Bacteriol 1988;170(7):3262-3268.

(37) Hopmeier P, Shenhav A, Glaser G, Rachmilewitz EA, Oppenheim A. A patient of german descent with (δbeta;deg;thalassemia carrying the sicilian type deletion of the δ and β globin genes. Hemoglobin 1988;12(1):39-51.

(38) Metzger S, Dror IB, Aizenman E, Schreiber G, Toone M, Friesen JD, et al. The nucleotide sequence and characterization of the relA gene of Escherichia coli. J Biol Chem 1988;263(30):15699-15704.

(39) Razin S, Nur I, Glaser G. Spiroplasma plasmids. Isr J Med Sci 1987;23(6):678-682.

(40) Hyman HC, Gafny R, Glaser G, Razin S. Transcription control elements of the Mycoplasma pneumoniae rRNA operon. Isr J Med Sci 1987;23(6):585-590.

(41) Nur I, Glaser G, Razin S. Free and integrated plasmid DNA in spiroplasmas. Curr Microbiol 1986;14(3):169-176.

(42) Qppenheim A, Karsai A, Treisman R, Fibach E, Treves A, Goldfarb A, et al. Beta-thalassemia: Analysis of mrna precursors of a mutant human globin gene with defective splicing using peripheral blood nucleated red blood cells. Hemoglobin 1986;10(6):573-586.

(43) Nur I, Szyf M, Razin A, Glaser G, Rottem S. Procaryotic and eucaryotic traits of DNA methylation in spiroplasmas (Mycoplasmas). J Bacteriol 1985;164(1):19-24.

(44) Razin S, Amikam D, Glaser G. Mycoplasmal ribosomal RNA genes and their use as probes for detection and identification of Mollicutes. Isr J Med Sci 1984;20(9):758-761.

(45) Glaser G, Amikam D, Razin S. Physical mapping of the ribosomal RNA genes of Mycoplasma capricolum. Nucleic Acids Res 1984;12(5):2421-2426.

(46) Razin S, Glaser G, Amikam D. Molecular and biological features of mollicutes (mycoplasmas). Ann Inst Pasteur Microbiol 1984;135(1):9-15.

(47) Amikam D, Glaser G, Razin S. Mycoplasmas (Mollicutes) have a low number of rRNA genes. J Bacteriol 1984;158(1):376-378.

(48) Razin S, Gross M, Worer M, Pollack Y, Glaser G. Detection of mycoplasmas infecting cell cultures by DNA hybridization. In Vitro 1984;20(5):404-408.

(49) Glaser G, Sarmientos P, Cashel M. Functional interrelationship between two tandem E. coli ribosomal RNA promoters. Nature 1983;302(5903):74-76.

(50) Razin S, Barile MF, Harasawa R, Amikam D, Glaser G. Characterization of the mycoplasma genome. Yale J Biol Med 1983;56(5-6):357-366.

(51) Glaser G, Rachmilewitz E. Gene therapy. Harefuah 1982;103(11):316-317.

(52) Glaser G, Karsai A, Kerem H, Yarkoni S, Rachmilewitz E. Prenatal diagnosis of β-thalassemia using genetic engineering techniques. Harefuah 1982;103(11):293-294+336.

(53) Amikam D, Razin S, Glaser G. Ribosomal RNA genes in mycoplasma. Nucleic Acids Res 1982;10(14):4215-4222.

(54) CHEVION M, NAVOK T, GLASER G, MAGER J. The Chemistry of Favism‐Inducing Compounds: The Properties of Isouramil and Divicine and Their Reaction with Glutathione. Eur J Biochem 1982;127(2):405-409.

(55) Glaser G, Razin A, Razin S. Stable RNA synthesis and its control in mycoplasma capricolum. Nucleic Acids Res 1981;9(15):3641-3646.

(56) Glaser G, Kobi S, Oppenheim AB. Fusion of the promoter region of rRNA operon rrnB to lac Z gene. Nucleic Acids Res 1980;8(19):4327-4336.

(57) Razin A, Urieli S, Pollack Y, Gruenbaum Y, Glaser G. Studies on the biological role of DNA methylation; IV. Mode of methylation of DNA in E. coli cells. Nucleic Acids Res 1980;8(8):1783-1792.

(58) Faliks D, Cohen H, Glaser G, Reshef L. Cycloheximide and pactamycin inhibit the rapid decrease in translatable mRNA activity of P-enolpyruvate carboxykinase (GTP). FEBS Lett 1980;109(1):112-116.

(59) Glaser G, Giloh H, Kasir J, Gross M, Mager J. On the mechanism of the glucose-induced ATP catabolism in ascites tumour cells and its reversal by pyruvate. Biochem J 1980;192(3):793-800.

(60) Cedar H, Solage A, Glaser G, Razin A. Direct detection of methylated cytosine in DNA by use of the restriction enzyme Mspl. Nucleic Acids Res 1979;6(6):2125-2132.

(61) Glaser G, Cashel M. In vitro transcripts from the rrn B ribosomal RNA cistron originate from two tandem promoters. Cell 1979;16(1):111-121.

(62) Reshef L, Faliks D, Bentor-Getter V, Glaser G. Effect of glucose feeding to fasted rats on the translational efficiency of liver cytosol phosphoenolpyruvate carboxykinase mRNA. FEBS Lett 1979;97(1):96-100.

(63) Glaser G, Enquist L, Cashel M. ColE1 cloning of a ribosomal RNA promoter region from λrifd18 by selection for lambda integration and excision functions. Gene 1977;2(3-4):159-172.

(64) Glaser G, Mager J. Proceedings: Studies on fructose hepatotoxicity in intact rats and in isolated liver cells. Isr J Med Sci 1975;11(11):1176.

(65) Glaser G, Mager J. Biochemical studies on the mechanism of action of liver poisons III. Depletion of liver glutathione in ethionine poisoning. Biochim Biophys Acta Gen Subj 1974;372(1):237-244.

(66) Glaser G, Mager J. Protective effect of adrenalectomy against the selective toxicity of ethionine to female rats. Isr J Med Sci 1972;8(10):1754-1756.

(67) Glaser G, Mager J. Biochemical studies on the mechanism of action of liver poisons II. Induction of fatty livers. Biochim Biophys Acta Gen Subj 1972;261(2):500-507.

(68) Glaser G, Mager J. Biochemical studies on the mechanism of action of liver poisons I. Inhibition of protein synthesis. Biochim Biophys Acta Gen Subj 1972;261(2):487-499.

(69) Razin A, Hershko A, Glaser G, Mager J. The oxidant effect of isouramil on red cell glutathione and its synergistic enhancement by ascorbic acid or 3,4-dihydroxyphenylalanine. Possible relation to the pathogenesis of favism. Isr J Med Sci 1968;4(4):852-857.

(70) Mager J, Glaser G, Razin A, Izak G, Bien S, Noam M. Metabolic effects of pyrimidines derived from fava bean glycosides on human erythrocytes deficient in glucose-6-phosphate dehydrogenase. Biochem Biophys Res Commun 1965;20(2):235-240.

(71) Razin A, Hershko A, Glaser G, Izak G, Mager J. Inhibition of hexokinase in glucose-6-phosphate dehydrogenase deficient erythrocytes by acetylphenylhydrazine. Isr J Med Sci 1965;1(4):843.