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The Faculty of Medicine - Developmental Biology and Cancer Research: Paroush Zeev

Researchers

 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Kushnir T, Bar-Cohen S, Mooshayef N, Lange R, Bar-Sinai A, Rozen H, et al. An activating mutation in ERK causes hyperplastic tumors in a scribble mutant tissue in drosophila. Genetics 2020;214(1):109-120.

(2) Papagianni A, Forés M, Shao W, He S, Koenecke N, Andreu MJ, et al. Capicua controls Toll/IL-1 signaling targets independently of RTK regulation. Proc Natl Acad Sci U S A 2018;115(8):1807-1812.

(3) Zahavi T, Maimon A, Kushnir T, Lange R, Berger E, Kornspan D, et al. Ras-Erk signaling induces phosphorylation of human TLE1 and downregulates its repressor function. Oncogene 2017;36(26):3729-3739.

(4) Grossman R, Paroush Z. High-throughput in vitro identification of direct MAPK/Erk substrates. Methods Mol Biol 2017;1487:127-135.

(5) Kushnir T, Mezuman S, Bar-Cohen S, Lange R, Paroush Z, Helman A. Novel interplay between JNK and Egfr signaling in Drosophila dorsal closure. PLoS Genet 2017;13(6).

(6) Johnston MJ, Bar-Cohen S, Paroush Z, Nystul TG. Phosphorylated groucho delays differentiation in the follicle stem cell lineage by providing a molecular memory of EGFR signaling in the niche. Development 2016;143(24):4631-4642.

(7) Cinnamon E, Makki R, Sawala A, Wickenberg LP, Blomquist GJ, Tittiger C, et al. Drosophila Spidey/Kar Regulates Oenocyte Growth via PI3-Kinase Signaling. PLoS Genet 2016;12(8).

(8) Forés M, Ajuria L, Samper N, Astigarraga S, Nieva C, Grossman R, et al. Origins of Context-Dependent Gene Repression by Capicua. PLoS Genet 2015;11(1).

(9) Helman A, Lim B, Andreu MJ, Kim Y, Shestkin T, Lu H, et al. RTK signaling modulates the Dorsal gradient. Development 2012;139(16):3032-3039.

(10) Jiménez G, Shvartsman SY, Paroush Z. The Capicua repressor - A general sensor of RTK signaling in development and disease. J Cell Sci 2012;125(6):1383-1391.

(11) Nir R, Grossman R, Paroush Z, Volk T. Phosphorylation of the drosophila melanogaster rna-binding protein how by MAPK/ERK enhances its dimerization and activity. PLoS Genet 2012;8(3).

(12) Helman A, Cinnamon E, Mezuman S, Hayouka Z, Von Ohlen T, Orian A, et al. Phosphorylation of groucho mediates RTK feedback inhibition and prolonged pathway target gene expression. Curr Biol 2011;21(13):1102-1110.

(13) Ajuria L, Nieva C, Winkler C, Kuo D, Samper N, José Andreu M, et al. Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila. Development (Cambridge) 2011;138(5):915-924.

(14) Moses C, Helman A, Paroush Z, Von Ohlen T. Phosphorylation of Ind by MAP kinase enhances Ind-dependent transcriptional repression. Dev Biol 2011;360(1):208-215.

(15) Kim Y, Paroush Z, Nairz K, Hafen E, Jiménez G, Shvartsman SY. Substrate-dependent control of MAPK phosphorylation in vivo. Mol Syst Biol 2011;7.

(16) Gene regulation by MAPK substrate competition. AIChE Annual Meeting, Conference Proceedings; 2010.

(17) Kim Y, Coppey M, Grossman R, Ajuria L, Jiménez G, Paroush Z, et al. MAPK Substrate Competition Integrates Patterning Signals in the Drosophila Embryo. Curr Biol 2010;20(5):446-451.

(18) Helman A, Paroush Z. Detection of RTK pathway activation in Drosophila using anti-dpERK immunofluorescence staining. Methods Mol Biol 2010;661:401-408.

(19) Cinnamon E, Paroush Z. Context-dependent regulation of Groucho/TLE-mediated repression. Curr Opin Genet Dev 2008;18(5):435-440.

(20) Kahali B, Trott R, Paroush Z, Allada R, Bishop CP, Bidwai AP. Drosophila CK2 phosphorylates Hairy and regulates its activity in vivo. Biochem Biophys Res Commun 2008;373(4):637-642.

(21) Cinnamon E, Helman A, Schyr RB-, Orian A, Jiménez G, Paroush Z. Multiple RTK pathways downregulate Groucho-mediated repression in Drosophila embryogenesis. Development (Cambridge) 2008;135(5):829-837.

(22) Orian A, Delrow JJ, Rosales Nieves AE, Abed M, Metzger D, Paroush Z, et al. A Myc-Groucho complex integrates EGF and Notch signaling to regulate neural development. Proc Natl Acad Sci U S A 2007;104(40):15771-15776.

(23) Astigarraga S, Grossman R, Díaz-Delfín J, Caelles C, Paroush Z, Jiménez G. A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling. EMBO J 2007;26(3):668-677.

(24) Hasson P, Paroush Z. Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE. Br J Cancer 2006;94(6):771-775.

(25) Goldstein RE, Cook O, Dinur T, Pisanté A, Karandikar UC, Bidwai A, et al. An eh1-like motif in Odd-skipped mediates recruitment of Groucho and repression in vivo. Mol Cell Biol 2005;25(24):10711-10720.

(26) Hasson P, Egoz N, Winkler C, Volohonsky G, Jia S, Dinur T, et al. EGFR signaling attenuates Groucho-dependent repression to antagonize Notch transcriptional output. Nat Genet 2005;37(1):101-105.

(27) Cinnamon E, Gur-Wahnon D, Helman A, St. Johnston D, Jiménez G, Paroush Z. Capicua integrates input from two maternal systems in Drosophila terminal patterning. EMBO J 2004;23(23):4571-4582.

(28) Song H, Hasson P, Paroush Z, Courey AJ. Groucho oligomerization is required for repression in vivo. Mol Cell Biol 2004;24(10):4341-4350.

(29) Hasson P, Müller B, Basler K, Paroush Z. Brinker requires two corepressors for maximal and versatile repression in Dpp signalling. EMBO J 2001;20(20):5725-5736.

(30) Kobayashi M, Goldstein RE, Fujioka M, Paroush Z, Jaynes JB. Groucho augments the repression of multiple even skipped target genes in establishing parasegment boundaries. Development (Cambridge) 2001;128(10):1805-1815.

(31) Trott RL, Kalive M, Paroush Z, Bidwai AP. Drosophila melanogaster casein kinase II interacts with and phosphorylates the basic helix-loop-helix proteins m5, m7, and m8 derived from the Enhancer of split complex. J Biol Chem 2001;276(3):2159-2167.

(32) Cook B, Bar-Yaacov M, Cohen Ben-Ami H, Goldstein RE, Paroush Z, Selinger Z, et al. Phospholipase C and termination of G-protein-mediated signalling in vivo. Nature Cell Biol 2000;2(5):296-301.

(33) Goldstein RE, Jiménez G, Cook O, Gur D, Paroush Z. Huckebein repressor activity in Drosophila terminal patterning is mediated by Groucho. Development (Cambridge) 1999;126(17):3747-3755.

(34) Levanon D, Goldstein RE, Bernstein Y, Tang H, Goldenberg D, Stifan S, et al. Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. Proc Natl Acad Sci U S A 1998;95(20):11590-11595.

(35) Paroush Z, Mark Wainwright S, Ish-Horowicz D. Torso signalling regulates terminal patterning in Drosophila by antagonising Groucho-mediated repression. Development 1997;124(19):3827-3834.

(36) Jiménez G, Paroush Z, Ish-Horowicz D. Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed. Genes Dev 1997;11(22):3072-3082.

(37) Dubnicoff T, Valentine SA, Chen G, Shi T, Lengyel JA, Paroush Z, et al. Conversion of Dorsal from an activator to a repressor by the global corepressor Groucho. Genes Dev 1997;11(22):2952-2957.

(38) Paroush Z, Finley Jr. RL, Kidd T, Wainwright SM, Ingham PW, Brent R, et al. Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell 1994;79(5):805-815.

(39) Paroush Z, Keshet I, Yisraeli J, Cedar H. Dynamics of demethylation and activation of the α-actin gene in myoblasts. Cell 1990;63(6):1229-1237.

(40) Frank D, Lichtenstein M, Paroush Z, Bergman Y, Shani M, Razin A, et al. Demethylation of genes in animal cells. Philos Trans R Soc Lond , B, Biol Sci 1990;326(1235):241-251.