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The Faculty of Medicine - Developmental Biology and Cancer Research: Tabach Yuval

Researchers

 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Skaliter O, Kitsberg Y, Sharon E, Shklarman E, Shor E, Masci T, et al. Spatial patterning of scent in petunia corolla is discriminated by bees and involves the ABCG1 transporter. Plant J 2021.

(2) Azar S, Udi S, Drori A, Hadar R, Nemirovski A, Vemuri KV, et al. Reversal of diet-induced hepatic steatosis by peripheral CB1 receptor blockade in mice is p53/miRNA-22/SIRT1/PPARα dependent. Mol Metab 2020;42.

(3) Braun M, Sharon E, Unterman I, Miller M, Shtern AM, Benenson S, et al. ACE2 Co-evolutionary Pattern Suggests Targets for Pharmaceutical Intervention in the COVID-19 Pandemic. iScience 2020;23(8).

(4) Miller M, Mellul A, Braun M, Sherill-Rofe D, Cohen E, Shpilt Z, et al. Titanium Tackles the Endoplasmic Reticulum: A First Genomic Study on a Titanium Anticancer Metallodrug. iScience 2020;23(7).

(5) Bloch I, Sherill-Rofe D, Stupp D, Unterman I, Beer H, Sharon E, et al. Optimization of co-evolution analysis through phylogenetic profiling reveals pathway-specific signals. Bioinformatics 2020;36(14):4116-4125.

(6) Wu M-, Nissim L, Stupp D, Pery E, Binder-Nissim A, Weisinger K, et al. A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS). Nat Commun 2019;10(1).

(7) Bauer M, Rahat D, Zisman E, Tabach Y, Lossos A, Meiner V, et al. MYORG Mutations: a Major Cause of Recessive Primary Familial Brain Calcification. Curr Neurol Neurosci Rep 2019;19(10).

(8) Qawasmi L, Braun M, Guberman I, Cohen E, Naddaf L, Mellul A, et al. Expanded CUG Repeats Trigger Disease Phenotype and Expression Changes through the RNAi Machinery in C. elegans. J Mol Biol 2019;431(9):1711-1728.

(9) Sherill-Rofe D, Rahat D, Findlay S, Mellul A, Guberman I, Braun M, et al. Mapping global and local coevolution across 600 species to identify novel homologous recombination repair genes. Genome Res 2019;29(3):439-448.

(10) Arkadir D, Lossos A, Rahat D, Abu Snineh M, Schueler-Furman O, Nitschke S, et al. MYORG is associated with recessive primary familial brain calcification. Ann Clin Transl Neurol 2019;6(1):106-113.

(11) Omar I, Guterman-Ram G, Rahat D, Tabach Y, Berger M, Levaot N. Schlafen2 mutation in mice causes an osteopetrotic phenotype due to a decrease in the number of osteoclast progenitors. Sci Rep 2018;8(1).

(12) Malcov-Brog H, Alpert A, Golan T, Parikh S, Nordlinger A, Netti F, et al. UV-Protection Timer Controls Linkage between Stress and Pigmentation Skin Protection Systems. Mol Cell 2018;72(3):444-456.e7.

(13) Nordlinger A, Dror S, Elkahloun A, Del Rio J, Stubbs E, Golan T, et al. Mutated MITF-E87R in Melanoma Enhances Tumor Progression via S100A4. J Invest Dermatol 2018;138(10):2216-2223.

(14) Findlay S, Heath J, Luo VM, Malina A, Morin T, Coulombe Y, et al. SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice. EMBO J 2018;37(18).

(15) Nissim L, Wu M-, Pery E, Binder-Nissim A, Suzuki HI, Stupp D, et al. Synthetic RNA-Based Immunomodulatory Gene Circuits for Cancer Immunotherapy. Cell 2017;171(5):1138-1150.e15.

(16) Wu E, Vashisht AA, Chapat C, Flamand MN, Cohen E, Sarov M, et al. A continuum of mRNP complexes in embryonic microRNA-mediated silencing. Nucleic Acids Res 2017;45(4):2081-2098.

(17) Hecht M, Tabib A, Kahan T, Orlanski S, Gropp M, Tabach Y, et al. Epigenetic mechanism of FMR1 inactivation in Fragile X syndrome. Int J Dev Biol 2017;61(3-5):285-292.

(18) Golan T, Messer AR, Amitai-Lange A, Melamed Z, Ohana R, Bell RE, et al. Interactions of Melanoma Cells with Distal Keratinocytes Trigger Metastasis via Notch Signaling Inhibition of MITF. Mol Cell 2015;59(4):664-676.

(19) Sadreyev IR, Ji F, Cohen E, Ruvkun G, Tabach Y. PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles. Nucleic Acids Res 2015;43(W1):W154-W159.

(20) Garcia SMDA, Tabach Y, Lourenço GF, Armakola M, Ruvkun G. Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans. Nat Struct Mol Biol 2014;21(8):712-720.

(21) Schwartz S, Agarwala SD, Mumbach MR, Jovanovic M, Mertins P, Shishkin A, et al. XHigh-Resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell 2013;155(6):X1409-1421.

(22) Tabach Y, Billi AC, Hayes GD, Newman MA, Zuk O, Gabel H, et al. Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence. Nature 2013;493(7434):694-698.

(23) Tabach Y, Golan T, Hernández-Hernández A, Messer AR, Fukuda T, Kouznetsova A, et al. Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling. Mol Syst Biol 2013;9.

(24) Tabach Y, Sakin IK, Buganim Y, Solomon H, Goldfinger N, Hovland R, et al. Amplification of the 20q chromosomal arm occurs early in tumorigenic transformation and may initiate cancer. PLoS ONE 2011;6(1).

(25) Kogan-Sakin I, Tabach Y, Buganim Y, Molchadsky A, Solomon H, Madar S, et al. Mutant p53 R175H upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells. Cell Death Differ 2011;18(2):271-281.

(26) Stambolsky P, Tabach Y, Fontemaggi G, Weisz L, Maor-Aloni R, Siegfried Z, et al. Erratum: Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53 (DOI:10.1016/j.ccr.2009.11.025). Cancer Cell 2010;17(5):523.

(27) Stambolsky P, Tabach Y, Fontemaggi G, Weisz L, Maor-Aloni R, Sigfried Z, et al. Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53. Cancer Cell 2010;17(3):273-285.

(28) Peller S, Tabach Y, Rotschild M, Garach-Joshua O, Cohen Y, Goldfinger N, et al. Identification of gene networks associated with erythroid differentiation. Blood Cells Mol Dis 2009;43(1):74-80.

(29) Tabach Y, Brosh R, Buganim Y, Reiner A, Zuk O, Yitzhaky A, et al. Wide-scale analysis of human functional transcription factor binding reveals a strong bias towards the transcription start site. PLoS ONE 2007;2(8).

(30) Einav U, Tabach Y, Getz G, Yitzhaky A, Ozbek U, Amariglio N, et al. Gene expression analysis reveals a strong signature of an interferon-induced pathway in childhood lymphoblastic leukemia as well as in breast and ovarian cancer. Oncogene 2005;24(42):6367-6375.

(31) Milyavsky M, Tabach Y, Shats I, Erez N, Cohen Y, Tang X, et al. Transcriptional programs following genetic alterations in p53, INK4A, and H-Ras genes along defined stages of malignant transformation. Cancer Res 2005;65(11):4530-4543.

(32) Tabach Y, Milyavsky M, Shats I, Brosh R, Zuk O, Yitzhaky A, et al. The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation. Mol Syst Biol 2005;1.

(33) Milyavsky M, Shats I, Erez N, Tang X, Senderovich S, Meerson A, et al. Prolonged Culture of Telomerase-Immortalized Human Fibroblasts Leads to a Premalignant Phenotype. Cancer Res 2003;63(21):7147-7157.