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The Faculty of Medicine - Biochemistry and Molecular Biology: Cohen Ehud

Researchers

 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 2021.

(2) Hoppe T, Cohen E. Organismal protein homeostasis mechanisms. Genetics 2020;215(4):889-901.

(3) Dagan H, Flashner-Abramson E, Vasudevan S, Jubran MR, Cohen E, Kravchenko-Balasha N. Exploring alzheimer’s disease molecular variability via calculation of personalized transcriptional signatures. Biomolecules 2020;10(4).

(4) Roitenberg N, Cohen E. Lipid Assemblies at the Crossroads of Aging, Proteostasis, and Neurodegeneration. Trends Cell Biol 2019;29(12):954-963.

(5) Levine A, Grushko D, Cohen E. Gene expression modulation by the linker of nucleoskeleton and cytoskeleton complex contributes to proteostasis. Aging Cell 2019;18(6).

(6) Qawasmi L, Braun M, Guberman I, Cohen E, Naddaf L, Mellul A, et al. Expanded CUG Repeats Trigger Disease Phenotype and Expression Changes through the RNAi Machinery in C. elegans. J Mol Biol 2019;431(9):1711-1728.

(7) Moll L, Roitenberg N, Bejerano-Sagie M, Boocholez H, Marques FC, Volovik Y, et al. The insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis in caenorhabditis elegans. eLife 2018;7.

(8) Roitenberg N, Bejerano-Sagie M, Boocholez H, Moll L, Marques FC, Golodetzki L, et al. Modulation of caveolae by insulin/IGF-1 signaling regulates aging of Caenorhabditis elegans. EMBO Rep 2018;19(8).

(9) Pan I, Roitenberg N, Cohen E. Vesicle-mediated secretion of misfolded prion protein molecules from cyclosporin A-treated cells. FASEB J 2018;32(3):1479-1492.

(10) Das P, Pan I, Cohen E, Reches M. Self-assembly of a metallo-peptide into a drug delivery system using a "switch on" displacement strategy. J Mater Chem B 2018;6(48):8228-8237.

(11) Itskovits E, Levine A, Cohen E, Zaslaver A. A multi-animal tracker for studying complex behaviors. BMC Biol 2017;15(1).

(12) Dubnikov T, Ben-Gedalya T, Cohen E. Protein quality control in health and disease. Cold Spring Harbor Perspect Biol 2017;9(3).

(13) Dubnikov T, Cohen E. The emerging roles of early protein folding events in the secretory pathway in the development of neurodegenerative maladies. Front Neurosci 2017;11(FEB).

(14) Ben-Gedalya T, Cohen E. From mutated genes to familial Alzheimer's disease. Cell Cycle 2016;15(7):877-878.

(15) Moll L, Ben-Gedalya T, Reuveni H, Cohen E. The inhibition of IGF-1 signaling promotes proteostasis by enhancing protein aggregation and deposition. FASEB J 2016;30(4):1659-1669.

(16) Dubnikov T, Ben-Gedalya T, Reiner R, Hoepfner D, Cabral WA, Marini JC, et al. PrP-containing aggresomes are cytosolic components of an ER quality control mechanism. J Cell Sci 2016;129(19):3635-3647.

(17) Ben-Gedalya T, Moll L, Bejerano-Sagie M, Frere S, Cabral WA, Friedmann-Morvinski D, et al. Alzheimer's disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction. EMBO J 2015;34(22):2820-2839.

(18) Dubnikov T, Cohen E. Proteostasis collapse, inter-tissue communication and the regulation of aging at the organismal level. Front Genet 2015;5(FEB).

(19) Marques FC, Volovik Y, Cohen E. The roles of cellular and organismal aging in the development of late-onset maladies. Annu Rev Pathol Mech Dis 2015;10:1-23.

(20) Volovik Y, Marques FC, Cohen E. The nematode Caenorhabditis elegans: A versatile model for the study of proteotoxicity and aging. Methods 2014;68(3):458-464.

(21) Moll L, El-Ami T, Cohen E. Selective manipulation of aging: A novel strategy for the treatment of neurodegenerative disorders. Swiss Med Wkly 2014;144.

(22) El-Ami T, Moll L, Carvalhal Marques F, Volovik Y, Reuveni H, Cohen E. A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity. Aging Cell 2014;13(1):165-174.

(23) Volovik Y, Moll L, Marques FC, Maman M, Bejerano-Sagie M, Cohen E. Differential Regulation of the Heat Shock Factor 1 and DAF-16 by Neuronal nhl-1 in the Nematode C.elegans. Cell Rep 2014;9(6):2192-2205.

(24) Bieschke J, Cohen E, Murray A, Dillin A, Kelly JW. Erratum: A kinetic assessment of the C. Elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis (Protein Science (2009) 18 (2231-2241) DOI: 10.1002/pro.234). Protein Sci 2013;22(11):1688.

(25) Maman M, Marques FC, Volovik Y, Dubnikov T, Bejerano-Sagie M, Cohen E. A neuronal GPCR is critical for the induction of the heat shock response in the Nematode C. elegans. J Neurosci 2013;33(14):6102-6111.

(26) Volovik Y, Maman M, Dubnikov T, Bejerano-Sagie M, Joyce D, Kapernick EA, et al. Temporal requirements of heat shock factor-1 for longevity assurance. Aging Cell 2012;11(3):491-499.

(27) Ben-Gedalya T, Cohen E. Quality Control Compartments Coming of Age. Traffic 2012;13(5):635-642.

(28) Ben-Gedalya T, Lyakhovetsky R, Yedidia Y, Bejerano-Sagie M, Kogan NM, Karpuj MV, et al. Cyclosporin-A-induced prion protein aggresomes are dynamic quality-control cellular compartments. J Cell Sci 2011;124(11):1891-1902.

(29) Du D, Murray AN, Cohen E, Kim H-, Simkovsky R, Dillin A, et al. A kinetic aggregation assay allowing selective and sensitive amyloid-β quantification in cells and tissues. Biochemistry 2011;50(10):1607-1617.

(30) Cohen E. Countering neurodegeneration by reducing the activity of the insulin/IGF signaling pathway: Current knowledge and future prospects. Exp Gerontol 2011;46(2-3):124-128.

(31) Dillin A, Cohen E. Ageing and protein aggregation-mediated disorders: From invertebrates to mammals. Philos Trans R Soc B Biol Sci 2011;366(1561):94-98.

(32) Cohen E, Dillin A. Aging and Aggregation-Mediated Proteotoxicity. Protein Misfolding Diseases: Current and Emerging Principles and Therapies; 2010. p. 631-644.

(33) Cohen E, Du D, Joyce D, Kapernick EA, Volovik Y, Kelly JW, et al. Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection. Aging Cell 2010;9(2):126-134.

(34) Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, et al. Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice. Cell 2009;139(6):1157-1169.

(35) Bieschke J, Cohen E, Murray A, Dillin A, Kelly JW. A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis. Protein Sci 2009;18(11):2231-2241.

(36) Cohen E, Dillin A. The insulin paradox: Aging, proteotoxicity and neurodegeneration. Nat Rev Neurosci 2008;9(10):759-767.

(37) Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A. Opposing activities protect against age-onset proteotoxicity. Science 2006;313(5793):1604-1610.

(38) Cohen E, Taraboulos A. Scrapie-like prion protein accumulates in aggresomes of cyclosporin A-treated cells. EMBO J 2003;22(3):404-417.