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The Faculty of Medicine - Biochemistry and Molecular Biology: Cohen Ehud


 Last updated December 2021 - Biochemistry and Molecular Biology 

List of Publications

(1) Grushko D, Boocholez H, Levine A, Cohen E. Temporal requirements of SKN-1/NRF as a regulator of lifespan and proteostasis in Caenorhabditis elegans. PLoS ONE 2021;16(7 July).

(2) Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy 2021;17(1):1-382.

(3) Hoppe T, Cohen E. Organismal protein homeostasis mechanisms. Genetics 2020;215(4):889-901.

(4) Dagan H, Flashner-Abramson E, Vasudevan S, Jubran MR, Cohen E, Kravchenko-Balasha N. Exploring alzheimer’s disease molecular variability via calculation of personalized transcriptional signatures. Biomolecules 2020;10(4).

(5) Roitenberg N, Cohen E. Lipid Assemblies at the Crossroads of Aging, Proteostasis, and Neurodegeneration. Trends Cell Biol 2019;29(12):954-963.

(6) Levine A, Grushko D, Cohen E. Gene expression modulation by the linker of nucleoskeleton and cytoskeleton complex contributes to proteostasis. Aging Cell 2019;18(6).

(7) Qawasmi L, Braun M, Guberman I, Cohen E, Naddaf L, Mellul A, et al. Expanded CUG Repeats Trigger Disease Phenotype and Expression Changes through the RNAi Machinery in C. elegans. J Mol Biol 2019;431(9):1711-1728.

(8) Moll L, Roitenberg N, Bejerano-Sagie M, Boocholez H, Marques FC, Volovik Y, et al. The insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis in caenorhabditis elegans. eLife 2018;7.

(9) Roitenberg N, Bejerano-Sagie M, Boocholez H, Moll L, Marques FC, Golodetzki L, et al. Modulation of caveolae by insulin/IGF-1 signaling regulates aging of Caenorhabditis elegans. EMBO Rep 2018;19(8).

(10) Pan I, Roitenberg N, Cohen E. Vesicle-mediated secretion of misfolded prion protein molecules from cyclosporin A-treated cells. FASEB J 2018;32(3):1479-1492.

(11) Das P, Pan I, Cohen E, Reches M. Self-assembly of a metallo-peptide into a drug delivery system using a "switch on" displacement strategy. J Mater Chem B 2018;6(48):8228-8237.

(12) Itskovits E, Levine A, Cohen E, Zaslaver A. A multi-animal tracker for studying complex behaviors. BMC Biol 2017;15(1).

(13) Dubnikov T, Ben-Gedalya T, Cohen E. Protein quality control in health and disease. Cold Spring Harbor Perspect Biol 2017;9(3).

(14) Dubnikov T, Cohen E. The emerging roles of early protein folding events in the secretory pathway in the development of neurodegenerative maladies. Front Neurosci 2017;11(FEB).

(15) Ben-Gedalya T, Cohen E. From mutated genes to familial Alzheimer's disease. Cell Cycle 2016;15(7):877-878.

(16) Moll L, Ben-Gedalya T, Reuveni H, Cohen E. The inhibition of IGF-1 signaling promotes proteostasis by enhancing protein aggregation and deposition. FASEB J 2016;30(4):1659-1669.

(17) Dubnikov T, Ben-Gedalya T, Reiner R, Hoepfner D, Cabral WA, Marini JC, et al. PrP-containing aggresomes are cytosolic components of an ER quality control mechanism. J Cell Sci 2016;129(19):3635-3647.

(18) Ben-Gedalya T, Moll L, Bejerano-Sagie M, Frere S, Cabral WA, Friedmann-Morvinski D, et al. Alzheimer's disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction. EMBO J 2015;34(22):2820-2839.

(19) Dubnikov T, Cohen E. Proteostasis collapse, inter-tissue communication and the regulation of aging at the organismal level. Front Genet 2015;5(FEB).

(20) Marques FC, Volovik Y, Cohen E. The roles of cellular and organismal aging in the development of late-onset maladies. Annu Rev Pathol Mech Dis 2015;10:1-23.

(21) Volovik Y, Moll L, Marques FC, Maman M, Bejerano-Sagie M, Cohen E. Differential Regulation of the Heat Shock Factor 1 and DAF-16 by Neuronal nhl-1 in the Nematode C.elegans. Cell Rep 2014;9(6):2192-2205.

(22) Volovik Y, Marques FC, Cohen E. The nematode Caenorhabditis elegans: A versatile model for the study of proteotoxicity and aging. Methods 2014;68(3):458-464.

(23) Moll L, El-Ami T, Cohen E. Selective manipulation of aging: A novel strategy for the treatment of neurodegenerative disorders. Swiss Med Wkly 2014;144.

(24) El-Ami T, Moll L, Carvalhal Marques F, Volovik Y, Reuveni H, Cohen E. A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity. Aging Cell 2014;13(1):165-174.

(25) Bieschke J, Cohen E, Murray A, Dillin A, Kelly JW. Erratum: A kinetic assessment of the C. Elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis (Protein Science (2009) 18 (2231-2241) DOI: 10.1002/pro.234). Protein Sci 2013;22(11):1688.

(26) Maman M, Marques FC, Volovik Y, Dubnikov T, Bejerano-Sagie M, Cohen E. A neuronal GPCR is critical for the induction of the heat shock response in the Nematode C. elegans. J Neurosci 2013;33(14):6102-6111.

(27) Volovik Y, Maman M, Dubnikov T, Bejerano-Sagie M, Joyce D, Kapernick EA, et al. Temporal requirements of heat shock factor-1 for longevity assurance. Aging Cell 2012;11(3):491-499.

(28) Ben-Gedalya T, Cohen E. Quality Control Compartments Coming of Age. Traffic 2012;13(5):635-642.

(29) Ben-Gedalya T, Lyakhovetsky R, Yedidia Y, Bejerano-Sagie M, Kogan NM, Karpuj MV, et al. Cyclosporin-A-induced prion protein aggresomes are dynamic quality-control cellular compartments. J Cell Sci 2011;124(11):1891-1902.

(30) Du D, Murray AN, Cohen E, Kim H-, Simkovsky R, Dillin A, et al. A kinetic aggregation assay allowing selective and sensitive amyloid-β quantification in cells and tissues. Biochemistry 2011;50(10):1607-1617.

(31) Cohen E. Countering neurodegeneration by reducing the activity of the insulin/IGF signaling pathway: Current knowledge and future prospects. Exp Gerontol 2011;46(2-3):124-128.

(32) Dillin A, Cohen E. Ageing and protein aggregation-mediated disorders: From invertebrates to mammals. Philos Trans R Soc B Biol Sci 2011;366(1561):94-98.

(33) Cohen E, Dillin A. Aging and Aggregation-Mediated Proteotoxicity. Protein Misfolding Diseases: Current and Emerging Principles and Therapies; 2010. p. 631-644.

(34) Cohen E, Du D, Joyce D, Kapernick EA, Volovik Y, Kelly JW, et al. Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection. Aging Cell 2010;9(2):126-134.

(35) Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, et al. Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice. Cell 2009;139(6):1157-1169.

(36) Bieschke J, Cohen E, Murray A, Dillin A, Kelly JW. A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis. Protein Sci 2009;18(11):2231-2241.

(37) Cohen E, Dillin A. The insulin paradox: Aging, proteotoxicity and neurodegeneration. Nat Rev Neurosci 2008;9(10):759-767.

(38) Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A. Opposing activities protect against age-onset proteotoxicity. Science 2006;313(5793):1604-1610.

(39) Cohen E, Taraboulos A. Scrapie-like prion protein accumulates in aggresomes of cyclosporin A-treated cells. EMBO J 2003;22(3):404-417.