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The Faculty of Medicine - Biochemistry and Molecular Biology: Panet Amos


 Last updated December 2021 - Biochemistry and Molecular Biology 

List of Publications

(1) Alfi O, Yakirevitch A, Wald O, Wandel O, Izhar U, Oiknine-Djian E, et al. Human nasal and lung tissues infected ex vivo with SARS-CoV-2 provide insights into differential tissue-specific and virus-specific innate immune responses in the upper and lower respiratory tract. J Virol 2021;95(14).

(2) Alfi O, From I, Yakirevitch A, Drendel M, Wolf M, Meir K, et al. Human nasal turbinate tissues in organ culture as a model for human cytomegalovirus infection at the mucosal entry site. J Virol 2020;94(19).

(3) Ilan O, Tal Y, Hershko AY, Shamriz O, Bohbot E, Tayeb S, et al. A novel tool for nasal polyp investigation: An Ex vivo Organ Culture System. Isr Med Assoc J 2020;22(1):48-52.

(4) Oiknine-Djian E, Bar-On S, Laskov I, Lantsberg D, Haynes RK, Panet A, et al. Artemisone demonstrates synergistic antiviral activity in combination with approved and experimental drugs active against human cytomegalovirus. Antiviral Res 2019;172.

(5) Weisblum Y, Oiknine-Djian E, Vorontsov OM, Haimov-Kochman R, Zakay-Rones Z, Meir K, et al. Erratum: Correction for Weisblum et al., "zika virus infects early-and midgestation human maternal decidual tissues, inducing distinct innate tissue responses in the maternal-fetal interface(Journal of Virology (2017) 91:4 (e01905-e01916) DOI: 10.1128/JVI.01905-16). J Virol 2019;93(22).

(6) Zafir-Lavie I, Sherbo S, Goltsman H, Badinter F, Yeini E, Ofek P, et al. Successful intracranial delivery of trastuzumab by gene-therapy for treatment of HER2-positive breast cancer brain metastases. J Control Release 2018;291:80-89.

(7) Oiknine-Djian E, Weisblum Y, Panet A, Wong HN, Haynes RK, Wolfa DG. The artemisinin derivative artemisone is a potent inhibitor of human cytomegalovirus replication. Antimicrob Agents Chemother 2018;62(7).

(8) Weisblum Y, Oiknine-Djian E, Zakay-Rones Z, Vorontsov O, Haimov-Kochman R, Nevo Y, et al. APOBEC3A is upregulated by human cytomegalovirus (HCMV) in the maternal-fetal interface, acting as an innate anti-HCMV effector. J Virol 2017;91(23).

(9) Glasner A, Oiknine-Djian E, Weisblum Y, Diab M, Panet A, Wolf DG, et al. Zika virus escapes NK cell detection by upregulating major histocompatibility complex class I molecules. J Virol 2017;91(22).

(10) Zafir-Lavie I, Miari R, Sherbo S, Krispel S, Tal O, Liran A, et al. Sustained secretion of anti-tumor necrosis factor α monoclonal antibody from ex vivo genetically engineered dermal tissue demonstrates therapeutic activity in mouse model of rheumatoid arthritis. J Gene Med 2017;19(8).

(11) Weisblum Y, Oiknine-Djian E, Vorontsov OM, Haimov-Kochman R, Zakay-Rones Z, Meir K, et al. Zika virus infects early- and midgestation human maternal decidual tissues, inducing distinct innate tissue responses in the maternal-fetal interface. J Virol 2017;91(4).

(12) Tsalenchuck Y, Steiner I, Panet A. Innate defense mechanisms against HSV-1 infection in the target tissues, skin and brain. J Neurovirol 2016;22(5):641-649.

(13) Shapir N, Miari R, Blum S, Schwartz D, Chernin G, Neil GA, et al. Preclinical and Preliminary Clinical Evaluation of Genetically Transduced Dermal Tissue Implants for the Sustained Secretion of Erythropoietin and Interferon α. Hum Gene Ther Clin Develop 2015;26(4):216-227.

(14) Weisblum Y, Panet A, Zakay-Rones Z, Vitenshtein A, Haimov-Kochman R, Goldman-Wohl D, et al. Human cytomegalovirus induces a distinct innate immune response in the maternal-fetal interface. Virology 2015;485:289-296.

(15) Berger AA, Gil Y, Panet A, Weisblum Y, Oiknine-Djian E, Gropp M, et al. Transition toward human cytomegalovirus susceptibility in early human embryonic stem cell-derived neural precursors. J Virol 2015;89(21):11159-11164.

(16) Weisblum Y, Panet A, Haimov-Kochman R, Wolf DG. Models of vertical cytomegalovirus (CMV) transmission and pathogenesis. Semin Immunopathol 2014;36(6):615-625.

(17) Hadas Y, Etlin A, Falk H, Avraham O, Kobiler O, Panet A, et al. A 'tool box' for deciphering neuronal circuits in the developing chick spinal cord. Nucleic Acids Res 2014;42(19).

(18) Tsalenchuck Y, Tzur T, Steiner I, Panet A. Different modes of herpes simplex virus type 1 spread in brain and skin tissues. J Neurovirol 2014;20(1):18-27.

(19) Yaacov B, Lazar I, Tayeb S, Frank S, Izhar U, Lotem M, et al. Extracellular matrix constituents interfere with Newcastle disease virus spread in solid tissue and diminish its potential oncolytic activity. J Gen Virol 2012;93(8):1664-1672.

(20) Weisblum Y, Panet A, Zichria Z-, Haimov-Kochman R, Goldman-Wohl D, Ariel I, et al. Modeling of human cytomegalovirus maternal-fetal transmission in a novel decidual organ culture. J Virol 2011;85(24):13204-13213.

(21) Cohen M, Braun E, Tsalenchuck Y, Panet A, Steiner I. Restrictions that control herpes simplex virus type 1 infection in mouse brain ex vivo. J Gen Virol 2011;92(10):2383-2393.

(22) Mitrani E, Pearlman A, Stern B, Miari R, Goltsman H, Kunicher N, et al. Biopump: Autologous skin-derived micro-organ genetically engineered to provide sustained continuous secretion of therapeutic proteins. Dermatol Ther 2011;24(5):489-497.

(23) Kunicher N, Tzur T, Amar D, Chaouat M, Yaacov B, Panet A. Characterization of factors that determine lentiviral vector tropism in skin tissue using an ex vivo model. J Gene Med 2011;13(4):209-220.

(24) Carrondo M, Panet A, Wirth D, Coroadinha AS, Cruz P, Falk H, et al. Integrated strategy for the production of therapeutic retroviral vectors. Hum Gene Ther 2011;22(3):370-379.

(25) Massler A, Kolodkin-Gal D, Meir K, Khalaileh A, Falk H, Izhar U, et al. Infant lungs are preferentially infected by adenovirus and herpes simplex virus type 1 vectors: Role of the tissue mesenchymal cells. J Gene Med 2011;13(2):101-113.

(26) Hochberg M, Kunicher N, Gilead L, Maly A, Falk H, Ingber A, et al. Tropism of herpes simplex virus type 1 to nonmelanoma skin cancers. Br J Dermatol 2011;164(2):273-281.

(27) Cohen-Haguenauer O, Creff N, Cruz P, Tunc C, Aïuti A, Baum C, et al. Relevance of an Academic GMP Pan-European Vector Infra-Structure (PEVI). Curr Gene Ther 2010;10(6):414-422.

(28) Lazar I, Yaacov B, Shiloach T, Eliahoo E, Kadouri L, Lotem M, et al. The oncolytic activity of Newcastle disease virus NDV-HUJ on chemoresistant primary melanoma cells is dependent on the proapoptotic activity of the inhibitor of apoptosis protein livin. J Virol 2010;84(1):639-646.

(29) Kolodkin-Gal D, Edden Y, Hartshtark Z, Ilan L, Khalaileh A, Pikarsky AJ, et al. Herpes simplex virus delivery to orthotopic rectal carcinoma results in an efficient and selective antitumor effect. Gene Ther 2009;16(7):905-915.

(30) Abbadessa G, Accolla R, Aiuti F, Albini A, Aldovini A, Alfano M, et al. Unsung hero Robert C. Gallo. Science 2009;323(5911):206-207.

(31) Carmo M, Dias JD, Panet A, Coroadinha AS, Carrondo MJ, Alves PM, et al. Thermosensitivity of the reverse transcription process as an inactivation mechanism of lentiviral vectors. Hum Gene Ther 2009;20(10):1168-1176.

(32) Yaacov B, Elihaoo E, Lazar I, Ben-Shlomo M, Greenbaum I, Panet A, et al. Selective oncolytic effect of an attenuated Newcastle disease virus (NDV-HUJ) in lung tumors (Cancer Gene Therapy (2008) 15, (795-807) DOI: 10.1038/cgt.2008.31). Cancer Gene Ther 2008;15(12):832.

(33) Carmo M, Panet A, Carrondo MJT, Alves PM, Cruz PE. From retroviral vector production to gene transfer: Spontaneous inactivation is caused by loss of reverse transcription capacity. J Gene Med 2008;10(4):383-391.

(34) Kunicher N, Falk H, Yaacov B, Tzur T, Panet A. Tropism of lentiviral vectors in skin tissue. Hum Gene Ther 2008;19(3):255-266.

(35) Yaacov B, Elihaoo E, Lazar I, Ben-Shlomo M, Greenbaum I, Panet A, et al. Selective oncolytic effect of an attenuated Newcastle disease virus (NDV-HUJ) in lung tumors. Cancer Gene Ther 2008;15(12):795-807.

(36) Kolodkin-Gal D, Zamir G, Edden Y, Pikarsky E, Pikarsky A, Haim H, et al. Herpes simplex virus type 1 preferentially targets human colon carcinoma: Role of extracellular matrix. J Virol 2008;82(2):999-1010.

(37) Aframian DJ, Amit D, David R, Shai E, Deutsch D, Honigman A, et al. Reengineering salivary gland cells to enhance protein secretion for use in developing artificial salivary gland device. Tissue Eng 2007;13(5):995-1001.

(38) Haim H, Steiner I, Panet A. Time frames for neutralization during the human immunodeficiency virus type 1 entry phase, as monitored in synchronously infected cell cultures. J Virol 2007;81(7):3525-3534.

(39) Kolodkin-Gal D, Zamir G, Pikarski E, Pikarski A, Shimony N, Wu H, et al. A novel system to study adenovirus tropism to normal and malignant colon tissues. Virology 2007;357(1):91-101.

(40) Braun E, Zimmerman T, Hur TB, Reinhartz E, Fellig Y, Panet A, et al. Neurotropism of herpes simplex virus type 1 in brain organ cultures. J Gen Virol 2006;87(10):2827-2837.

(41) Yang Z-, Chakrabarti BK, Xu L, Welcher B, Kong W-, Leung K, et al. Erratum: Selective modification of variable loops alters tropism and enhances immunogenicity of human immunodeficiency virus type 1 envelope (Journal of Virology (2004) 78, 8 (4029-4036)). J Virol 2006;80(8):4206.

(42) Hagay Y, Lahav J, Levanon A, Varon D, Brill A, Panet A. Molecular characterization of an human monoclonal antibody that interacts with a sulfated tyrosine-containing epitope of the GPIb receptor and inhibits platelet functions. Mol Immunol 2006;43(5):443-453.

(43) Carmo M, Faria TQ, Falk H, Coroadinha AS, Teixeira M, Merten O-, et al. Relationship between retroviral vector membrane and vector stability. J Gen Virol 2006;87(5):1349-1356.

(44) Freeman AI, Zakay-Rones Z, Gomori JM, Linetsky E, Rasooly L, Greenbaum E, et al. Phase I/II trial of intravenous NDV-HUJ oncolytic virus in recurrent glioblastoma multiforme. Mol Ther 2006;13(1):221-228.

(45) Matza-Porges S, Horresh I, Tavor E, Panet A, Honigman A. Expression of an anti apoptotic recombinant short peptide in mammalian cells. Apoptosis 2005;10(5):987-996.

(46) Panet A, Braun E, Honigman A, Steiner I. Involvement of cellular death signals in the reactivation of herpes simplex virus type 1 and lambda bacteriophage from a latent state. J Theor Biol 2005;236(1):88-94.

(47) Brill-Almon E, Stern B, Afik D, Kaye J, Langer N, Bellomo S, et al. Ex vivo transduction of human dermal tissue structures for autologous implantation production and delivery of therapeutic proteins. Mol Ther 2005;12(2):274-282.

(48) Hasson E, Slovatizky Y, Shimoni Y, Falk H, Panet A, Mitrani E. Solid tissues can be manipulated ex vivo and used as vehicles for gene therapy. J Gene Med 2005;7(7):926-935.

(49) Shai E, Palmon A, Panet A, Marmary Y, Sherman Y, Curran MA, et al. Prolonged transgene expression in murine salivary glands following non-primate lentiviral vector transduction. Mol Ther 2005;12(1):137-143.

(50) Chakrabarti BK, Ling X, Yang Z-, Montefiori DC, Panet A, Kong W-, et al. Expanded breadth of virus neutralization after immunization with a multiclade envelope HIV vaccine candidate. Vaccine 2005;23(26):3434-3445.

(51) Puxeddu I, Alian A, Piliponsky AM, Ribatti D, Panet A, Levi-Schaffer F. Human peripheral blood eosinophils induce angiogenesis. Int J Biochem Cell Biol 2005;37(3):628-636.

(52) Haim H, Steiner I, Panet A. Synchronized infection of cell cultures by magnetically controlled virus. J Virol 2005;79(1):622-625.

(53) Ganesh L, Leung K, Loré K, Levin R, Panet A, Schwartz O, et al. Infection of specific dendritic cells by CCR5-tropic human immunodeficiency virus type 1 promotes cell-mediated transmission of virus resistant to broadly neutralizing antibodies. J Virol 2004;78(21):11980-11987.

(54) Yang Z-, Chakrabarti BK, Xu L, Welcher B, Kong W-, Leung K, et al. Selective Modification of Variable Loops Alters Tropism and Enhances Immunogenicity of Human Immunodeficiency Virus Type 1 Envelope. J Virol 2004;78(8):4029-4036.

(55) Mador N, Braun E, Haim H, Ariel I, Panet A, Steiner I. Transgenic Mouse with the Herpes Simplex Virus Type 1 Latency-Associated Gene: Expression and Function of the Transgene. J Virol 2003;77(23):12421-12429.

(56) Matza-Porges S, Tavor E, Panet A, Honigman A. Intracellular expression of a functional short peptide confers resistance to apoptosis. Exp Cell Res 2003;290(1):60-67.

(57) Hagay Y, Lahav J, Levanon A, Panet A. Function-modulating human monoclonal antibodies against platelet-membrane receptors isolated from a phage-display library. J Thromb Haemost 2003;1(8):1829-1836.

(58) Banin E, Obolensky A, Piontek E, Falk H, Pikarsky E, Pe'er J, et al. Gene delivery by viral vectors in primary cultures of lacrimal gland tissue. Invest Ophthalmol Vis Sci 2003;44(4):1529-1533.

(59) Mador N, Panet A, Steiner I. The latency-associated gene of herpes simplex virus type 1 (HSV-1) interferes with superinfection by HSV-1. J Neurovirol 2002;8(SUPPL. 2):97-102.

(60) Alian A, Eldor A, Falk H, Panet A. Viral mediated gene transfer to sprouting blood vessels during angiogenesis. J Virol Methods 2002;105(1):1-11.

(61) Shapira-Nahor O, Maayan S, Peden KWC, Rabinowitz R, Schlesinger M, Alian A, et al. Replication of HIV-1 deleted Nef mutants in chronically immune activated human T cells. Virology 2002;303(1):138-145.

(62) Shai E, Falk H, Honigman A, Panet A, Palmon A. Gene transfer mediated by different viral vectors following direct cannulation of mouse submandibular salivary glands. Eur J Oral Sci 2002;110(3):254-260.

(63) Chowers I, Banin E, Hemo Y, Porat R, Falk H, Keshet E, et al. Gene transfer by viral vectors into blood vessels in a rat model of retinopathy of prematurity. Br J Ophthalmol 2001;85(8):991-995.

(64) Ashhab Y, Alian A, Polliack A, Panet A, Yehuda DB. Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern. FEBS Lett 2001;495(1-2):56-60.

(65) Van Oosten M, Rensen PCN, Van Amersfoort ES, Van Eck M, Van Dam A-, Brevé JJP, et al. Apolipoprotein E protects against bacterial lipopolysaccharide-induced lethality: A new therapeutic approach to treat Gram-negative sepsis. J Biol Chem 2001;276(12):8820-8824.

(66) Honigman A, Zeira E, Ohana P, Abramovitz R, Tavor E, Bar I, et al. Imaging transgene expression in live animals. Mol Ther 2001;4(3):239-249.

(67) Alian A, Sela-Donenfeld D, Panet A, Eldor A. Avian hemangioma retrovirus induces cell proliferation via the envelope (env) gene. Virology 2000;276(1):161-168.

(68) Shapira-Nahor O, Kalinkovich A, Weisman Z, Greenberg Z, Nahmias J, Shapiro M, et al. Increased susceptibility to HIV-1 infection of peripheral blood mononuclear cells from chronically immune-activated individuals [10]. AIDS 1998;12(13):1731-1733.

(69) Wolf DG, Honigman A, Lazarovits J, Tavor E, Panet A. Characterization of the human cytomegalovirus UL97 gene product as a virion-associated protein kinase. Brief report. Arch Virol 1998;143(6):1223-1232.

(70) Mador N, Goldenberg D, Cohen O, Panet A, Steiner I. Herpes simplex virus type 1 latency-associated transcripts suppress viral replication and reduce immediate-early gene mRNA levels in a neuronal cell line. J Virol 1998;72(6):5067-5075.

(71) Goldenberg D, Mador N, Panet A, Steiner I. Tissue specific distribution of the herpes simplex virus type 1 latency-associated transcripts on polyribosomes during latent infection. J Neurovirol 1998;4(4):426-432.

(72) Mador N, Falk H, Bergel M, Panet A, Hochman J. Variant mouse lymphoma cells modified response to interferon demonstrate enhanced immunogenicity. Cancer Immunol Immunother 1997;44(5):249-256.

(73) Goldenberg D, Mador N, Ball MJ, Panet A, Steiner I. The abundant latency-associated transcripts of herpes simplex virus type 1 are bound to polyribosomes in cultured neuronal cells and during latent infection in mouse trigeminal ganglia. J Virol 1997;71(4):2897-2904.

(74) Shapira-Nahor O, Marcus H, Segall H, Lubin I, Slavin S, Panet A, et al. Human T cells recovered from human/Balb radiation chimeras are hypersensitive to human immunodeficiency virus type 1 infection. J Virol 1997;71(6):4495-4501.

(75) Ezov N, Nimrod A, Parizada B, Werber MM, Goldlust A, Greenstein LA, et al. Recombinant polypeptides derived from the fibrin binding domain of fibronectin are potential agents for the imaging of blood clots. Thromb Haemost 1997;77(4):796-803.

(76) Mumcuoglu KY, Galun R, Kaminchik Y, Panet A, Levanon A. Antihemostatic activity in salivary glands of the human body louse, Pediculus humanus humanus (Anoplura: Pediculidae). J Insect Physiol 1996;42(11-12):1083-1087.

(77) Incardona F, Lawler J, Cataldo D, Panet A, Legrand Y, Foidart JM, et al. Heparin-binding domain, type 1 and type 2 repeats of thrombospondin mediate its interaction with human breast cancer cells. J Cell Biochem 1996;62(4):431-442.

(78) Ben-Artzi H, Shemesh J, Zeelon E, Amit B, Kleiman L, Gorecki M, et al. Molecular analysis of the second template switch during reverse transcription of the HIV RNA template. Biochemistry 1996;35(32):10549-10557.

(79) Sela-Donenfeld D, Korner M, Pick M, Eldor A, Panet A. Programmed endothelial cell death induced by an avian hemangioma retrovirus is density dependent. Virology 1996;223(1):233-237.

(80) Artzi HB, Shemesh J, Zeelon E, Amit B, Kleiman L, Gorecki M, et al. Ribonuclease H activity during initiation of reverse transcription using tRNAlys/RNA primer/template of human immunodeficiency virus. Arch Biochem Biophys 1996;325(2):209-216.

(81) Kornowski R, Eldor A, Werber MM, Ezov N, Zwang E, Nimrod A, et al. Enhancement of recombinant tissue-type plasminogen activator thrombolysis with a selective factor Xa inhibitor derived from the leech Hirudo medicinalis: Comparison with heparin and hirudin in a rabbit thrombosis model. Coron Artery Dis 1996;7(12):903-909.

(82) Wyde PR, Moore DK, Miles Pimentel D, Gilbert BE, Nimrod R, Panet A. Recombinant superoxide dismutase (SOD) administered by aerosol inhibits respiratory syncytial virus infection in cotton rats. Antiviral Res 1996;31(3):173-184.

(83) Ben Artzi H, Panet A. Molecular analysis of the reverse transcription process of the HIV genome. INT ANTIVIRAL NEWS 1996;4(1):11-13.

(84) Eldor A, Sela-Donenfeld D, Korner M, Pick M, Resnick-Roguel N, Panet A. Injury Models Of The Vascular Endothelium: Apoptosis And Loss Of Thromboresistance Induced By A Viral Protein. Pathophysiol Haemost Thromb 1996;26:37-45.

(85) Sidwell RW, Huffman JH, Bailey KW, Wong MH, Nimrod A, Panet A. Inhibitory effects of recombinant manganese superoxide dismutase on influenza virus infections in mice. Antimicrob Agents Chemother 1996;40(11):2626-2631.

(86) Sixma JJ, Ijsseldijk MJW, Hindriks G, Van Henrita Zanten G, Gorecki M, Panet A, et al. Adhesion of Blood Platelets Is Inhibited by VCL, a Recombinant Fragment (Leucine504 to Lysine728) of von Willebrand Factor. Arterioscler Thromb Vasc Biol 1996;16(1):64-71.

(87) Honigman A, Falk H, Mador N, Rosental T, Panet A. Translation efficiency of the human T-cell leukemia virus (HTLV-2) gag gene modulates the frequency of ribosomal frameshifting. Virology 1995;208(1):312-318.

(88) Mador N, Panet A, Latchman D, Steiner I. Expression and splicing of the latency-associated transcripts of herpes simplex virus type 1 in neuronal and non-neuronal cell lines. J Biochem 1995;117(6):1288-1297.

(89) Browning PJ, Roberts DD, Zabrenetzky V, Bryant J, Kaplan M, Washington RH, et al. Apolipoprotein E (ApoE), a Novel Heparin-binding Protein Inhibits the Development of Kaposi's Sarcoma-like Lesions in BALB/c nu/nu Mice. J Exp Med 1994;180(5):1949-1954.

(90) Steiner I, Birmanns B, Panet A. Sun exposure and amyotrophic lateral sclerosis [4]. Ann Intern Med 1994;120(10):893.

(91) Yao S-, Ober JC, Garfinkel LI, Hagay Y, Ezov N, Ferguson JJ, et al. Blockade of platelet membrane glycoprotein Ib receptors delays intracoronary thrombogenesis, enhances thrombolysis, and delays coronary artery reocclusion in dogs. Circulation 1994;89(6):2822-2828.

(92) Vogel T, Guo N‐, Guy R, Drezlich N, Krutzsch HC, Blake DA, et al. Apolipoprotein E: A potent inhibitor of endothelial and tumor cell proliferation. J Cell Biochem 1994;54(3):299-308.

(93) Shouval D, Ilan Y, Adler R, Deepen R, Panet A, Even-Chen Z, et al. Improved immunogenicity in mice of a mammalian cell-derived recombinant hepatitis B vaccine containing pre-S1 and pre-S2 antigens as compared with conventional yeast-derived vaccines. Vaccine 1994;12(15):1453-1459.

(94) Kaminchik J, Margalit R, Yaish S, Drummer H, Amit B, Sarver N, et al. Cellular Distribution of HIV Type 1 Nef Protein: Identification of Domains in Nef Required for Association with Membrane and Detergent-Insoluble Cellular Matrix. AIDS Res Hum Retroviruses 1994;10(8):1003-1010.

(95) Legrand C, Morandi V, Mendelovitz S, Shaked H, Hartman JR, Panet A. Selective inhibition of platelet macroaggregate formation by a recombinant heparin-binding domain of human thrombospondin. Arterioscler Thromb 1994;14(11):1784-1791.

(96) Kollmus H, Honigman A, Panet A, Hauser H. The sequences of and distance between two cis-acting signals determine the efficiency of ribosomal frameshifting in human immunodeficiency virus type 1 and human T-cell leukemia virus type II in vivo. J Virol 1994;68(9):6087-6091.

(97) Vogel T, Guo N‐, Krutzsch HC, Blake DA, Hartman J, Mendelovitz S, et al. Modulation of endothelial cell proliferation, adhesion, and motility by recombinant heparin‐binding domain and synthetic peptides from the type I repeats of thrombospondin. J Cell Biochem 1993;53(1):74-84.

(98) Falk H, Mador N, Udi R, Panet A, Honigman A. Two cis-acting signals control ribosomal frameshift between human T-cell leukemia virus type II gag and pro genes. J Virol 1993;67(10):6273-6277.

(99) Ben-Artzi H, Zeelon E, Amit B, Wortzel A, Gorecki M, Panet A. RNase H activity of reverse transcriptases on substrates derived from the 5' end of retroviral genome. J Biol Chem 1993;268(22):16465-16471.

(100) Vogel T, Werber MM, Guy R, Levanon A, Nimrod A, Legrand C, et al. Studies on fibronectin and its domains: I. Novel recombinant cell-binding domain of fibronectin-a modulator of human platelet functions. Arch Biochem Biophys 1993;300(1):501-509.

(101) Ben-artzi H, Zeelon E, Le-grice SF, Gorecki M, Panet A. Characterization of the double stranded RNA dependent RNase activity associated with recombinant reverse transcriptases. Nucleic Acids Res 1992;20(19):5115-5118.

(102) Ben-Artzi H, Zeelon E, Gorecki M, Panet A. Double-stranded RNA-dependent RNase activity associated with human immunodeficiency virus type 1 reverse transcriptase. Proc Natl Acad Sci U S A 1992;89(3):927-931.

(103) Fischer M, Lifshitz R, Katz T, Liefer I, Ben-Artzi H, Gorecki M, et al. Comparative analysis of native and cysteine-deficient HIV-1 reverse transcriptase. Protein Expr Purif 1992;3(4):301-307.

(104) Kaminchik J, Sarver N, Gorecki M, Panet A. Molecular characterization of HIV1 nef protein. Res Virol 1992;143(C):50-52.

(105) Kaminchik J, Bashan N, Itach A, Sarver N, Gorecki M, Panet A. Genetic characterization of human immunodeficiency virus type 1 nef gene products translated in vitro and expressed in mammalian cells. J Virol 1991;65(2):583-588.

(106) Bar-Shira A, Panet A, Honigman A. An RNA secondary structure juxtaposes two remote genetic signals for human T-cell leukemia virus type I RNA 3'-end processing. J Virol 1991;65(10):5165-5173.

(107) Honigman A, Wolf D, Yaish S, Falk H, Panet A. cis acting RNA sequences control the gag-pol translation readthrough in murine leukemia virus. Virology 1991;183(1):313-319.

(108) Yedgar S, Vlodavsky I, Panet A, Reisfeld N, Eldor A. Interferon enhances phospholipase A2 activity in bovine aortic endothelial cells. Eicosanoids 1990;3(4):225-229.

(109) Kaminchik J, Bashan N, Pinchasi D, Amit B, Sarver N, Johnston MI, et al. Expression and biochemical characterization of human immunodeficiency virus type 1 nef gene product. J Virol 1990;64(7):3447-3454.

(110) Unge T, Ahola H, Bhikhabhai R, Bäckbro K, Lövgren S, Strandberg B, et al. Expression, Purification, and Crystallization of the HIV-1 Reverse Transcriptase (RT). AIDS Res Hum Retroviruses 1990;6(11):1297-1303.

(111) Oberman F, Panet A. Characterization of the Early Steps of Herpes Simplex Virus Replication in Interferon-Treated Human Cells. J Interferon Res 1989;9(5):563-571.

(112) Mador N, Panet A, Honigman A. Translation of gag, pro, and pol gene products of human T-cell leukemia virus type 2. J Virol 1989;63(5):2400-2404.

(113) Resnick-Roguel N, Burstein H, Hamburger J, Panet A, Eldor A, Vlodavsky I, et al. Cytocidal effect caused by the envelope glycoprotein of a newly isolated avian hemangioma-inducing retrovirus. J Virol 1989;63(10):4325-4330.

(114) Panet R, Amir I, Snyder D, Zonenshein L, Atlan H, Laskov R, et al. Effect of Na+ flux inhibitors on induction of c‐fos, c‐myc, and ODC genes during cell cycle. J Cell Physiol 1989;140(1):161-168.

(115) Oberman F, Panet A. Inhibition of transcription of herpes simplex virus immediate early genes in interferon-treated human cells. J Gen Virol 1988;69(6):1167-1177.

(116) Hochman J, Mador N, Gloger I, Falk H, Panet A. Isolation and characterization of interferon-resistant variants from S49 mouse lymphoma. Exp Cell Res 1988;177(1):37-46.

(117) Panet A, Baltimore D. Characterization of endonuclease activities in Moloney murine leukemia virus and its replication-defective mutants. J Virol 1987;61(5):1756-1760.

(118) Eldor A, Vlodavsky I, Heyns AD, Panet A. The effect and interactions of interferon and arachidonate products with vessel wall cells. Prog Clin Biol Res 1987;242:323-328.

(119) Arad G, Hershkovitz M, Panet A, Loyter A. Use of reconstituted Sendai virus envelopes for fusion-mediated microinjection of double-stranded RNA: inhibition of protein synthesis in interferon-treated cells. Biochim Biophys Acta Biomembr 1986;859(1):88-94.

(120) Straub P, Domke I, Kirchner H, Jacobsen H, Panet A. Synthesis of herpes simplex virus proteins and nucleic acids in interferon-treated macrophages. Virology 1986;150(2):411-418.

(121) Gloger I, Panet A. Glutamine starvation of murine leukaemia virus-infected cells inhibits the readthrough of the gag-pol genes and proteolytic processing of the gag polyprotein. J Gen Virol 1986;67(10):2207-2213.

(122) Krause D, Panet A, Arad G, Dieffenbach CW, Silverman RH. Independent regulation of ppp(A2'p)(n)A-dependent RNase in NIH 3T3, clone 1 cells by growth arrest and interferon treatment. J Biol Chem 1985;260(16):9501-9507.

(123) Panet R, Amir I, Atlan H, Panet A. Control of K+ influx in 3T3 cells transformed by a conditional mutant of Rous sarcoma virus. J Biol Chem 1985;260(29):15752-15761.

(124) Panet A, Arad G, Rappoport S, Hochman Y. Analysis of the (2'-5') oligoadenylate system by characterization of cells deficient in their response to interferon. Prog Clin Biol Res 1985;202:345-350.

(125) Hochman J, Mador N, Panet A. Tubular structures in S49 mouse lymphoma are regulated through in vivo host-cell interaction and in vitro interferon treatment. J Cell Biol 1985;100(5):1351-1356.

(126) Rachmilewitz D, Karmeli F, Panet A. Interferon inhibits prostaglandin E2 synthesis and stimulates (2'-5')oligoadenylate synthetase activity in peripehral blood mononuclear cells of inflammatory bowel disease patients. J Interferon Res 1985;5(4):629-635.

(127) Heyns AdP, Eldor A, Vlodavsky I, Kaiser N, Fridman R, Panet A. The antiproliferative effect of interferon and the mitogenic activity of growth factors are independent cell cycle events. Studies with vascular smooth muscle cells and endothelial cells. Exp Cell Res 1985;161(2):297-306.

(128) Domke I, Straub P, Jacobsen H, Kirchner H, Panet A. Inhibition of replication of herpes simplex virus in mouse macrophages by interferons. J Gen Virol 1985;66(10):2231-2236.

(129) Honigman A, Bar-Shira A, Silberberg H, Panet A. Generation of a uniform 3' end RNA of murine leukemia virus. J Virol 1985;53(1):330-334.

(130) Einhorn S, Vlodavsky I, Fuks Z, Eldor A, Panet A. Production and characterization of interferon from endothelial cells. J Cell Physiol 1985;122(2):200-204.

(131) Gloger I, Arad G, Panet A. Regulation of Moloney murine leukemia virus replication in chronically infected cells arrested at the G0/G1 phase. J Virol 1985;54(3):844-850.

(132) Zusman I, Engelhard D, Yaffe P, Ron A, Panet A, Ornoy A. Effects of interferon and encephalomyocarditis virus on in vitro development of preimplantation mouse embryos with and without the zona pellucida. Teratology 1984;29(3):405-409.

(133) Gloger I, Panet A. Synthesis of herpes simplex virus proteins in interferon-treated human cells. J Gen Virol 1984;65(6):1107-1111.

(134) Panet A. Regulation of the antiviral and anticellular activities of interferon by exogenous double-stranded RNA. Mol Cell Biochem 1983;52(2):153-160.

(135) Honigman A, Panet A. A unique sequence in murine leukemia virus long terminal repeat functions as a termination signal for transcription in Escherichia coli. J Virol 1983;45(1):456-461.

(136) Panet A, Falk H. Inhibition by interferon of herpes simplex virus thymidine kinase and DNA polymerase in infected and biochemically transformed cells. J Gen Virol 1983;64(9):1999-2006.

(137) Rappoport S, Arad G, Lapidot Y, Panet A. Activation of ribonuclease F by the two isomers (2'-5') oligoadenylate and (3'-5') oligoadenylate. FEBS Lett 1982;149(1):47-50.

(138) Margalith M, Falk H, Panet A. Differential inhibition of DNA polymerase and RNase H activities of the reverse transcriptase by phosphonoformate. Mol Cell Biochem 1982;43(2):97-103.

(139) Kimchi A, Shure H, Lapidot Y, Rapoport S, Panet A, Revel M. Antimitogenic effects of interferon and (2′-5′)-oligoadenylate in synchronized 3T3 fibroblasts. FEBS Lett 1981;134(2):212-216.

(140) Panet A, Czarniecki CW, Falk H, Friedman RM. Effect of 2′5′-oligoadenylic acid on a mouse cell line partially resistant to interferon. Virology 1981;114(2):567-572.

(141) EPSTEIN DA, CZARNIECKI CW, JACOBSEN H, FRIEDMAN RM, PANET A. A Mouse Cell Line, which Is Unprotected by Interferon against Lytic Virus Infection, Lacks Ribonuclease F Activity. Eur J Biochem 1981;118(1):9-15.

(142) Czarniecki CW, Sreevalsan T, Friedman RM, Panet A. Dissociation of interferon effects on murine leukemia virus and encephalomyocarditis virus replication in mouse cells. J Virol 1981;37(2):827-831.

(143) Guttman-Bass N, Cedar H, Panet A. Quantification of newly synthesized virus RNA in Moloney murine leukaemia virus-infected cells. J Gen Virol 1980;48(2):341-350.

(144) Czarniecki CW, Panet A, Friedman RM. Variability of interferon effect on murine leukemia virus. J Supramol Struct Cell Biochem 1980;12(SUPPL. 4).

(145) Panet A, Falk H, Fenyö EM, Klein G. Restriction of murine leukemia proviral gene expression in somatic mouse cell hybrids. Virology 1980;106(2):197-206.

(146) Gazit B, Panet A, Cedar H. Reconstitution of a deoxyribonuclease I-sensitive structure on active genes. Proc Natl Acad Sci U S A 1980;77(4 I):1787-1790.

(147) Cedar H, Panet A. Activation of the endogenous proviral genes in mouse cells is not followed by increased sensitivity to deoxyribonuclease I digestion. J Gen Virol 1979;45(3):765-770.

(148) Panet A, Gorecki M, Bratosin S, Aloni Y. Electron microscopic evidence for splicing of moloney murine leukemia virus RNAs. Nucleic Acids Res 1978;5(9):3219-3230.

(149) Panet A, Berliner H. Binding of tRNA to reverse transcriptase of RNA tumor viruses. J Virol 1978;26(2):214-220.

(150) Panet A, Kra-oz Z. A competition immunoassay for characterizing the reverse transcriptase of mammalian RNA tumor viruses. Virology 1978;89(1):95-101.

(151) Panet A, Weil G, Friis RR. Binding of tryptophanyl-tRNA to the reverse transcriptase of replication-defective avian sarcoma viruses. J Virol 1978;28(2):434-443.

(152) Gorecki M, Panet A. Discrimination of DNA Polymerase and RNase H Activities in Reverse Transcriptase of Avian Myeloblastosis Virus. Biochemistry 1978;17(12):2438-2442.

(153) Panet A. Studies on the intracellular reverse transcriptase of RNA tumor viruses. Isr J Med Sci 1977;13(7):731-739.

(154) Haseltine WA, Panet A, Smoler D, Baltimore D, Peters G, Harada F, et al. Interaction of Tryptophan tRNA and Avian Myeloblastosis Virus Reverse Transcriptase: Further Characterization of the Binding Reaction. Biochemistry 1977;16(16):3625-3632.

(155) Panet A, Cedar H. Selective degradation of integrated murine leukemia proviral DNA by deoxyribonucleases. Cell 1977;11(4):933-940.

(156) Peters G, Harada F, Dahlberg JE, Panet A, Haseltine WA, Baltimore D. Low molecular weight RNAs of Moloney murine leukemia virus: identification of the primer for RNA directed DNA synthesis. J Virol 1977;21(3):1031-1041.

(157) Kleppe R, Sekiya T, Loewen PC, Kleppe K, Agarwal KL, Büchi H, et al. Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. XI. Enzymatic joining to form the total DNA duplex. J Biol Chem 1976;251(3):667-675.

(158) Loewen PC, Miller RC, Panet A, Sekiya T, Khorana HG. Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. VIII. Enzymatic joining of the chemically synthesized segments to form DNA duplexes corresponding to nucleotide sequences 23-60 and 23-66. J Biol Chem 1976;251(3):642-650.

(159) Panet A, Kleppe R, Kleppe K, Khorana HG. Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. IX. Enzymatic joining of chemically synthesized deoxyribopolynucleotide segments corresponding to nucleotide sequence 57-94. J Biol Chem 1976;251(3):651-657.

(160) Khorana HG, Agarwal KL, Besmer P, Büchi H, Caruthers MH, Cashion PJ, et al. Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. I. General introduction. J Biol Chem 1976;251(3):565-570.

(161) Haseltine WA, Kleid DG, Panet A, Rothenberg E, Baltimore D. Ordered transcription of RNA tumor virus genomes. J Mol Biol 1976;106(1):109-131.

(162) Panet A, Haseltine WA, Baltimore D, Peters G, Harada F, Dahlberg JE. Specific binding of tryptophan transfer RNA to avian myeloblastosis virus RNA dependent DNA polymerase (reverse transcriptase). Proc Natl Acad Sci U S A 1975;72(7):2535-2539.

(163) Panet A, Baltimore D, Hanafusa T. Quantitation of avian RNA tumor virus reverse transcriptase by radioimmunoassay. J Virol 1975;16(1):146-152.

(164) Panet A, Khorana HG. Studies on polynucleotides. The linkage of deoxyribopolynucleotide templates to cellulose and its use in their replication. J Biol Chem 1974;249(16):5213-5221.

(165) Panet A, Verma IM, Baltimore D. Role of the subunits of the avian RNA tumor virus reverse transcriptase. SYMP QUANT BIOL 1974;39(2):919-923.

(166) Panet A, van de Sande JH, Loewen PC, Khorana HG, Raae AJ, Lillehaug JR, et al. Physical Characterization and Simultaneous Purification of Bacteriophage T4 Induced Polynucleotide Kinase, Polynucleotide Ligase, and Deoxyribonucleic Acid Polymerase. Biochemistry 1973;12(25):5045-5050.

(167) Degroot N, Panet A, Lapidot Y. Studies on the Specificity of the Interaction Between Peptidyl‐tRNA and E. Coli Ribosomes, Initiation and Elongation Factors. Isr J Chem 1972;10(4):775-785.

(168) DE Groot N, Panet A, Lapidot Y. The Binding of Purified Phe‐tRNA and Peptidyl‐tRNAPhe to Escherichia coli Ribosomes. Eur J Biochem 1971;23(3):523-527.

(169) DE Groot N, Panet A, Lapidot Y. Reaction of Puromycin with Chemically Prepared Peptidyl Transfer RNA. Eur J Biochem 1970;15(2):215-221.

(170) Panet A, de Groot N, Lapidot Y. Substrate Specificity of Escherichia coli Peptidyl‐Transferase. Eur J Biochem 1970;15(2):222-225.

(171) De Groot N, Panet A, Fry-Shafrir I, Lapidot Y. Modified aminoacyl-tRNA. IV. The behaviour of acyl[14C]phenylalanyl-tRNA in a ribosomal system from wheat germ. BBA Section Nucleic Acids And Protein Synthesis 1968;161(1):137-146.

(172) Lapidot Y, De Groot N, Rappoport S, Panet A. A chemical synthesis of glycylglycyl[14C]phenylalanyl-tRNA and glycylglycylglycyl[14C]phenylalanyl-tRNA. BBA Section Nucleic Acids And Protein Synthesis 1968;157(2):433-435.

(173) de Groot N, Panet A, Lapidot Y. Enzymatic hydrolysis of peptidyl-tRNA. Biochem Biophys Res Commun 1968;31(1):37-42.

(174) de Groot N, Panet A, Lapidot Y. Some biological properties of acetyl- and formylphenylalanyl-sRNA. Biochem Biophys Res Commun 1967;26(4):447-453.

(175) de Groot N, Lapidot Y, Panet A, Wolman Y. The synthesis of N-acetylphenylalanyl-sRNA. Biochem Biophys Res Commun 1966;25(1):17-22.