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The Faculty of Medicine - Biochemistry and Molecular Biology: Sharon Ronit

Researchers

 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Schechter M, Atias M, Abd Elhadi S, Davidi D, Gitler D, Sharon R. A-synuclein facilitates endocytosis by elevating the steady-state levels of phosphatidylinositol 4,5-bisphosphate. J Biol Chem 2020;295(52):18076-18090.

(2) Schechter M, Grigoletto J, Abd-Elhadi S, Glickstein H, Friedman A, Serrano GE, et al. A role for α-Synuclein in axon growth and its implications in corticostriatal glutamatergic plasticity in Parkinson's disease. Mol Neurodegeneration 2020;15(1).

(3) Davidi D, Schechter M, Elhadi SA, Matatov A, Nathanson L, Sharon R. α-Synuclein Translocates to the Nucleus to Activate Retinoic-Acid-Dependent Gene Transcription. iScience 2020;23(3).

(4) Trudler D, Levy-Barazany H, Nash Y, Samuel L, Sharon R, Frenkel D. Alpha synuclein deficiency increases CD4+ T-cells pro-inflammatory profile in a Nurr1-dependent manner. J Neurochem 2020;152(1):61-71.

(5) Abd Elhadi S, Grigoletto J, Poli M, Arosio P, Arkadir D, Sharon R. α-Synuclein in blood cells differentiates Parkinson’s disease from healthy controls. Ann Clin Transl Neurol 2019;6(12):2426-2436.

(6) Grigoletto J, Pukaß K, Gamliel A, Davidi D, Katz-Brull R, Richter-Landsberg C, et al. Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss. Acta Neuropathol Commun 2017;5(1):37.

(7) De Franceschi G, Fecchio C, Sharon R, Schapira AHV, Proukakis C, Bellotti V, et al. α-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotection. J Biol Chem 2017;292(17):6927-6937.

(8) Lasser-Katz E, Simchovitz A, Chiu W-, Oertel WH, Sharon R, Soreq H, et al. Mutant α -synuclein overexpression induces stressless pacemaking in vagal motoneurons at risk in parkinson’s disease. J Neurosci 2017;37(1):47-57.

(9) Abd-Elhadi S, Basora M, Vilas D, Tolosa E, Sharon R. Total α-synuclein levels in human blood cells, CSF, and saliva determined by a lipid-ELISA. Anal Bioanal Chem 2016;408(27):7669-7677.

(10) Cooper G, Lasser-Katz E, Simchovitz A, Sharon R, Soreq H, James Surmeier D, et al. Functional segregation of voltage-activated calcium channels in motoneurons of the dorsal motor nucleus of the vagus. J Neurophysiol 2015;114(3):1513-1520.

(11) Abd-Elhadi S, Honig A, Simhi-Haham D, Schechter M, Linetsky E, Ben-Hur T, et al. Total and proteinase K-resistant α-synuclein levels in erythrocytes, determined by their ability to bind phospholipids, associate with parkinson's disease. Sci Rep 2015;5.

(12) Yakunin E, Kisos H, Kulik W, Grigoletto J, Wanders RJA, Sharon R. The regulation of catalase activity by PPAR γ is affected by α-synuclein. Ann Clin Transl Neurol 2014;1(3):145-159.

(13) Kisos H, Ben-Gedalya T, Sharon R. The clathrin-dependent localization of dopamine transporter to surface membranes is affected by α-Synuclein. J Mol Neurosci 2014;52(2):167-176.

(14) Zarbiv Y, Simhi-Haham D, Israeli E, Elhadi SA, Grigoletto J, Sharon R. Lysine residues at the first and second KTKEGV repeats mediate α-Synuclein binding to membrane phospholipids. Neurobiol Dis 2014;70:90-98.

(15) Kisos H, Pukaß K, Ben-Hur T, Richter-Landsberg C, Sharon R. Increased Neuronal α-Synuclein Pathology Associates with Its Accumulation in Oligodendrocytes in Mice Modeling α-Synucleinopathies. PLoS ONE 2012;7(10).

(16) Yakunin E, Loeb V, Kisos H, Biala Y, Yehuda S, Yaari Y, et al. α-Synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease. Brain Pathol 2012;22(3):280-294.

(17) Israeli E, Yakunin E, Zarbiv Y, Hacohen-Solovich A, Kisos H, Loeb V, et al. α-Synuclein expression selectively affects tumorigenesis in mice modeling Parkinson's disease. PLoS ONE 2011;6(5).

(18) Loeb V, Yakunin E, Saada A, Sharon R. The transgenic overexpression of α-synuclein and not its related pathology associates with complex I inhibition. J Biol Chem 2010;285(10):7334-7343.

(19) Yakunin E, Moser A, Loeb V, Saada A, Faust P, Crane DI, et al. α-synuclein abnormalities in mouse models of peroxisome biogenesis disorders. J Neurosci Res 2010;88(4):866-876.

(20) Gedalya TB, Loeb V, Israeli E, Altschuler Y, Selkoe DJ, Sharon R. α-Synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling. Traffic 2009;10(2):218-234.

(21) Israeli E, Sharon R. β-synuclein occurs in vivo in lipid-associated oligomers and forms hetero-oligomers with α-synuclein. J Neurochem 2009;108(2):465-474.

(22) Haviv Y, Avrahami D, Ovadia H, Ben-Hur T, Gabizon R, Sharon R. Induced neuroprotection independently from PrPSc accumulation in a mouse model for prion disease treated with simvastatin. Arch Neurol 2008;65(6):762-775.

(23) Assayag K, Yakunin E, Loeb V, Selkoe DJ, Sharon R. Polyunsaturated fatty acids induce α-synuclein-related pathogenic changes in neuronal cells. Am J Pathol 2007;171(6):2000-2011.

(24) Sharon R, Bar-Joseph I, Mirick GE, Serhan CN, Selkoe DJ. Altered Fatty Acid Composition of Dopaminergic Neurons Expressing α-Synuclein and Human Brains with α-Synucleinopathies. J Biol Chem 2003;278(50):49874-49881.

(25) Sharon R, Bar-Joseph I, Frosch MP, Walsh DM, Hamilton JA, Selkoe DJ. The formation of highly soluble oligomers of α-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron 2003;37(4):583-595.

(26) Schlossmacher MG, Frosch MP, Gai WP, Medina M, Sharma N, Forno L, et al. Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am J Pathol 2002;160(5):1655-1667.

(27) Sharon R, Goldberg MS, Bar-Josef I, Betensky RA, Shen J, Selkoe DJ. α-synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins. Proc Natl Acad Sci U S A 2001;98(16):9110-9115.

(28) Vainstein A, Sharon R. Biogenesis of petunia and carnation corolla chloroplasts: changes in the abundance of nuclear and plastid‐encoded photosynthesis‐specific gene products during flower development. Physiol Plant 1993;89(1):192-198.