Skip to Main Content
It looks like you're using Internet Explorer 11 or older. This website works best with modern browsers such as the latest versions of Chrome, Firefox, Safari, and Edge. If you continue with this browser, you may see unexpected results.

The Faculty of Medicine - Biochemistry and Molecular Biology: Sharon Ronit


 Last updated December 2021 - Biochemistry and Molecular Biology 

List of Publications

(1) Schechter M, Sharon R. An Emerging Role for Phosphoinositides in the Pathophysiology of Parkinson's Disease. J Parkinson's Dis 2021;11(4):1725-1750.

(2) Schechter M, Atias M, Abd Elhadi S, Davidi D, Gitler D, Sharon R. A-synuclein facilitates endocytosis by elevating the steady-state levels of phosphatidylinositol 4,5-bisphosphate. J Biol Chem 2020;295(52):18076-18090.

(3) Schechter M, Grigoletto J, Abd-Elhadi S, Glickstein H, Friedman A, Serrano GE, et al. A role for α-Synuclein in axon growth and its implications in corticostriatal glutamatergic plasticity in Parkinson's disease. Mol Neurodegeneration 2020;15(1).

(4) Davidi D, Schechter M, Elhadi SA, Matatov A, Nathanson L, Sharon R. α-Synuclein Translocates to the Nucleus to Activate Retinoic-Acid-Dependent Gene Transcription. iScience 2020;23(3).

(5) Trudler D, Levy-Barazany H, Nash Y, Samuel L, Sharon R, Frenkel D. Alpha synuclein deficiency increases CD4+ T-cells pro-inflammatory profile in a Nurr1-dependent manner. J Neurochem 2020;152(1):61-71.

(6) Abd Elhadi S, Grigoletto J, Poli M, Arosio P, Arkadir D, Sharon R. α-Synuclein in blood cells differentiates Parkinson’s disease from healthy controls. Ann Clin Transl Neurol 2019;6(12):2426-2436.

(7) Grigoletto J, Pukaß K, Gamliel A, Davidi D, Katz-Brull R, Richter-Landsberg C, et al. Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss. Acta Neuropathol Commun 2017;5(1):37.

(8) De Franceschi G, Fecchio C, Sharon R, Schapira AHV, Proukakis C, Bellotti V, et al. α-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotection. J Biol Chem 2017;292(17):6927-6937.

(9) Lasser-Katz E, Simchovitz A, Chiu W-, Oertel WH, Sharon R, Soreq H, et al. Mutant α -synuclein overexpression induces stressless pacemaking in vagal motoneurons at risk in parkinson’s disease. J Neurosci 2017;37(1):47-57.

(10) Abd-Elhadi S, Basora M, Vilas D, Tolosa E, Sharon R. Total α-synuclein levels in human blood cells, CSF, and saliva determined by a lipid-ELISA. Anal Bioanal Chem 2016;408(27):7669-7677.

(11) Cooper G, Lasser-Katz E, Simchovitz A, Sharon R, Soreq H, James Surmeier D, et al. Functional segregation of voltage-activated calcium channels in motoneurons of the dorsal motor nucleus of the vagus. J Neurophysiol 2015;114(3):1513-1520.

(12) Abd-Elhadi S, Honig A, Simhi-Haham D, Schechter M, Linetsky E, Ben-Hur T, et al. Total and proteinase K-resistant α-synuclein levels in erythrocytes, determined by their ability to bind phospholipids, associate with parkinson's disease. Sci Rep 2015;5.

(13) Yakunin E, Kisos H, Kulik W, Grigoletto J, Wanders RJA, Sharon R. The regulation of catalase activity by PPAR γ is affected by α-synuclein. Ann Clin Transl Neurol 2014;1(3):145-159.

(14) Kisos H, Ben-Gedalya T, Sharon R. The clathrin-dependent localization of dopamine transporter to surface membranes is affected by α-Synuclein. J Mol Neurosci 2014;52(2):167-176.

(15) Zarbiv Y, Simhi-Haham D, Israeli E, Elhadi SA, Grigoletto J, Sharon R. Lysine residues at the first and second KTKEGV repeats mediate α-Synuclein binding to membrane phospholipids. Neurobiol Dis 2014;70:90-98.

(16) Kisos H, Pukaß K, Ben-Hur T, Richter-Landsberg C, Sharon R. Increased Neuronal α-Synuclein Pathology Associates with Its Accumulation in Oligodendrocytes in Mice Modeling α-Synucleinopathies. PLoS ONE 2012;7(10).

(17) Yakunin E, Loeb V, Kisos H, Biala Y, Yehuda S, Yaari Y, et al. α-Synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease. Brain Pathol 2012;22(3):280-294.

(18) Israeli E, Yakunin E, Zarbiv Y, Hacohen-Solovich A, Kisos H, Loeb V, et al. α-Synuclein expression selectively affects tumorigenesis in mice modeling Parkinson's disease. PLoS ONE 2011;6(5).

(19) Loeb V, Yakunin E, Saada A, Sharon R. The transgenic overexpression of α-synuclein and not its related pathology associates with complex I inhibition. J Biol Chem 2010;285(10):7334-7343.

(20) Yakunin E, Moser A, Loeb V, Saada A, Faust P, Crane DI, et al. α-synuclein abnormalities in mouse models of peroxisome biogenesis disorders. J Neurosci Res 2010;88(4):866-876.

(21) Gedalya TB, Loeb V, Israeli E, Altschuler Y, Selkoe DJ, Sharon R. α-Synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling. Traffic 2009;10(2):218-234.

(22) Israeli E, Sharon R. β-synuclein occurs in vivo in lipid-associated oligomers and forms hetero-oligomers with α-synuclein. J Neurochem 2009;108(2):465-474.

(23) Haviv Y, Avrahami D, Ovadia H, Ben-Hur T, Gabizon R, Sharon R. Induced neuroprotection independently from PrPSc accumulation in a mouse model for prion disease treated with simvastatin. Arch Neurol 2008;65(6):762-775.

(24) Assayag K, Yakunin E, Loeb V, Selkoe DJ, Sharon R. Polyunsaturated fatty acids induce α-synuclein-related pathogenic changes in neuronal cells. Am J Pathol 2007;171(6):2000-2011.

(25) Sharon R, Bar-Joseph I, Mirick GE, Serhan CN, Selkoe DJ. Altered Fatty Acid Composition of Dopaminergic Neurons Expressing α-Synuclein and Human Brains with α-Synucleinopathies. J Biol Chem 2003;278(50):49874-49881.

(26) Sharon R, Bar-Joseph I, Frosch MP, Walsh DM, Hamilton JA, Selkoe DJ. The formation of highly soluble oligomers of α-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron 2003;37(4):583-595.

(27) Schlossmacher MG, Frosch MP, Gai WP, Medina M, Sharma N, Forno L, et al. Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am J Pathol 2002;160(5):1655-1667.

(28) Sharon R, Goldberg MS, Bar-Josef I, Betensky RA, Shen J, Selkoe DJ. α-synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins. Proc Natl Acad Sci U S A 2001;98(16):9110-9115.

(29) Vainstein A, Sharon R. Biogenesis of petunia and carnation corolla chloroplasts: changes in the abundance of nuclear and plastid‐encoded photosynthesis‐specific gene products during flower development. Physiol Plant 1993;89(1):192-198.