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The Faculty of Medicine - Biochemistry and Molecular Biology: Shaul Yoav

Researchers

 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Khatib A, Solaimuthu B, Yosef MB, Rmaileh AA, Tanna M, Oren G, et al. The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype. Proc Natl Acad Sci U S A 2020;117(35):21420-21431.

(2) Rmaileh AA, Solaimuthu B, Tanna M, Khatib A, Yosef MB, Hayashi A, et al. Large-scale differential gene expression transcriptomic analysis identifies a metabolic signature shared by all cancer cells. Biomolecules 2020;10(5).

(3) Luu M, Pautz S, Kohl V, Singh R, Romero R, Lucas S, et al. The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes. Nat Commun 2019;10(1).

(4) Neumann-Raizel H, Shilo A, Lev S, Mogilevsky M, Katz B, Shneor D, et al. 2-APB and CBD-mediated targeting of charged cytotoxic compounds into tumor cells suggests the involvement of TRPV2 channels. Front Pharmacol 2019;10.

(5) Gershkovitz M, Fainsod-Levi T, Khawaled S, Shaul ME, Sionov RV, Cohen-Daniel L, et al. Microenvironmental cues determine tumor cell susceptibility to neutrophil cytotoxicity. Cancer Res 2018;78(17):5050-5059.

(6) Gershkovitz M, Caspi Y, Fainsod-Levi T, Katz B, Michaeli J, Khawaled S, et al. TRPM2 mediates neutrophil killing of disseminated tumor cells. Cancer Res 2018;78(10):2680-2690.

(7) Aebersold DM, Shaul YD, Yung Y, Yarom N, Yao Z, Hanoch T, et al. Correction: "Extracellular signal-regulated kinase 1c (ERK1c), a novel 42- kilodalton ERK, demonstrates unique modes of regulation, localization, and function." [Molecular and Cellular Biology, 24, 22, (2004) (10000-10015)] doi 10.1128/MCB.24.22.10000. Mol Cell Biol 2017;37(18).

(8) Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJYM, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol 2016;12(6):452-458.

(9) Patterson HC, Gerbeth C, Thiru P, Vögtle NF, Knoll M, Shahsafaei A, et al. Erratum: A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling (Proceedings of the National Academy of Sciences of the United States of America (2015) 112 (E5679-E5688) (DOI:10.1073/pnas.1517932112)). Proc Natl Acad Sci U S A 2016;113(14):E2094.

(10) Shaul YD, Yuan B, Thiru P, Nutter-Upham A, McCallum S, Lanzkron C, et al. MERAV: A tool for comparing gene expression across human tissues and cell types. Nucleic Acids Res 2016;44(D1):D560-D566.

(11) Patterson HC, Gerbeth C, Thiru P, Vögtle NF, Knoll M, Shahsafaei A, et al. A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling. Proc Natl Acad Sci U S A 2015;112(42):E5679-E5688.

(12) Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, et al. Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell 2014;158(5):1094-1109.

(13) Kanarek N, Grivennikov SI, Leshets M, Lasry A, Alkalay I, Horwitz E, et al. Critical role for IL-1β in DNA damageinduced mucositis. Proc Natl Acad Sci U S A 2014;111(6):E702-E711.

(14) Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 2011;476(7360):346-350.

(15) Lindquist RA, Ottina KA, Wheeler DB, Hsu PP, Thoreen CC, Guertin DA, et al. Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. Genome Res 2011;21(3):433-446.

(16) Shaul YD, Gibor G, Plotnikov A, Seger R. Specific phosphorylation and activation of ERK1c by MEK1b: A unique route in the ERK cascade. Genes Dev 2009;23(15):1779-1790.

(17) Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, et al. The rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 2008;320(5882):1496-1501.

(18) Shaul YD, Seger R. The MEK/ERK cascade: From signaling specificity to diverse functions. Biochim Biophys Acta Mol Cell Res 2007;1773(8):1213-1226.

(19) Shaul YD, Seger R. ERK1c regulates Golgi fragmentation during mitosis. J Cell Biol 2006;172(6):885-897.

(20) Shaul Y, Seger R. The detection of MAPK signaling. Curr Protoc Mol Biol 2006;Chapter 18.

(21) Shaul Y, Seger R. The detection of MAPK signaling. Curr Protoc Cell Biol 2005;Chapter 14.

(22) Aebersold DM, Shaul YD, Yung Y, Yarom N, Yao Z, Hanoch T, et al. Extracellular Signal-Regulated Kinase 1c (ERK1c), a novel 42-kilodalton ERK, demonstrates unique modes of regulation, localization, and function. Mol Cell Biol 2004;24(22):10000-10015.

(23) Shaul YD, Seger R. Use of inhibitors in the study of MAPK signaling. Methods Mol Biol 2004;250:113-126.

(24) Litvak V, Shaul YD, Shulewitz M, Amarilio R, Carmon S, Lev S. Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain. Curr Biol 2002;12(17):1513-1518.

(25) Litvak V, Tian D, Shaul YD, Lev S. Targeting of PYK2 to focal adhesions as a cellular mechanism for convergence between integrins and G protein-coupled receptor signaling cascades. J Biol Chem 2000;275(42):32736-32746.