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The Faculty of Medicine - Biochemistry and Molecular Biology: Shaulian Eitan

Researchers

 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Zahavi T, Maimon A, Kushnir T, Lange R, Berger E, Kornspan D, et al. Ras-Erk signaling induces phosphorylation of human TLE1 and downregulates its repressor function. Oncogene 2017;36(26):3729-3739.

(2) Anzi S, Shaulian E. Jun proteins and AP-1 in tumorigenesis. Molecular Oncology: Causes of Cancer and Targets for Treatment; 2015. p. 319-327.

(3) Blumberg A, Sailaja BS, Kundaje A, Levin L, Dadon S, Shmorak S, et al. Transcription factors bind negatively selected sites within human mtDNA genes. Genome Biolog Evol 2014;6(10):2634-2646.

(4) Sionov RV, Netzer E, Shaulian E. Differential regulation of FBXW7 isoforms by various stress stimuli. Cell Cycle 2013;12(22):3547-3554.

(5) Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012;8(4):445-544.

(6) Baruch K, Gur-Arie L, Nadler C, Koby S, Yerushalmi G, Ben-Neriah Y, et al. Metalloprotease type III effectors that specifically cleave JNK and NF-κB. EMBO J 2011;30(1):221-231.

(7) Galli F, Rossi M, D'Alessandra Y, De Simone M, Lopardo T, Haupt Y, et al. MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation. J Cell Sci 2010;123(14):2423-2433.

(8) Shaulian E. AP-1 - The Jun proteins: Oncogenes or tumor suppressors in disguise? Cell Signal 2010;22(6):894-899.

(9) Yogev O, Shaulian E. Jun proteins inhibit autophagy and induce cell death. Autophagy 2010;6(4):566-567.

(10) Yogev O, Goldberg R, Anzi S, Yogev O, Shaulian E. Jun proteins are starvation-regulated inhibitors of autophagy. Cancer Res 2010;70(6):2318-2327.

(11) Yogev O, Yogev O, Singer E, Shaulian E, Goldberg M, Fox TD, et al. Fumarase: A mitochondrial metabolic enzyme and a cytosolic/nuclear component of the dna damage response. PloS Biol 2010;8(3).

(12) Finkin S, Aylon Y, Anzi S, Oren M, Shaulian E. Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug-induced polyploidy. Oncogene 2008;27(32):4411-4421.

(13) Anzi S, Finkin S, Shaulian E. Transcriptional repression of c-Jun's E3 ubiquitin ligases contributes to c-Jun induction by UV. Cell Signal 2008;20(5):862-871.

(14) Yogev O, Saadon K, Anzi S, Inoue K, Shaulian E. DNA damage-dependent translocation of B23 and p19ARF is regulated by the Jun N-terminal kinase pathway. Cancer Res 2008;68(5):1398-1406.

(15) Yogev O, Anzi S, Inoue K, Shaulian E. Induction of transcriptionally active Jun proteins regulates drug-induced senescence. J Biol Chem 2006;281(45):34475-34483.

(16) Shaulian E. Transcription Factors: AP-1. Encyclopedia of Respiratory Medicine, Four-Volume Set; 2006. p. 251-257.

(17) Lerdrup M, Holmberg C, Dietrich N, Shaulian E, Herdegen T, Jäättelä M, et al. Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis. Biochim Biophys Acta Mol Cell Res 2005;1745(1):29-37.

(18) Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nature Cell Biol 2002;4(5):E131-E136.

(19) Karin M, Shaulian E. AP-1: Linking hydrogen peroxide and oxidative stress to the control of cell proliferation and death. IUBMB Life 2001;52(1-2):17-24.

(20) Shaulian E, Karin M. AP-1 in cell proliferation and survival. Oncogene 2001;20(19 REV. ISS. 2):2390-2400.

(21) Shaulian E, Schreiber M, Piu F, Beeche M, Wagner EF, Karin M. The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest. Cell 2000;103(6):897-908.

(22) Shaulian E, Karin M. Stress-induced JNK activation is independent of Gadd45 induction. J Biol Chem 1999;274(42):29595-29598.

(23) Ratziu V, Lalazar A, Wong L, Dang Q, Collins C, Shaulian E, et al. Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis. Proc Natl Acad Sci U S A 1998;95(16):9500-9505.

(24) Hosokawa K, Aharoni D, Dantes A, Shaulian E, Schere-levy C, Atzmon R, et al. Modulation of Mdm2 expression and p53-induced apoptosis in immortalized human ovarian granulosa cells. Endocrinology 1998;139(11):4688-4700.

(25) Friedman SL, Shaulian E, Littlewood T, Resnitzky D, Oren M. Resistance to p53-mediated growth arrest and apoptosis in Hep 3B hepatoma cells. Oncogene 1997;15(1):63-70.

(26) Shaulian E, Resnitzky D, Shifman O, Blandino G, Amsterdam A, Yayon A, et al. Induction of Mdm2 and enhancement of cell survival by bFGF. Oncogene 1997;15(22):2717-2725.

(27) Haupt Y, Rowan S, Shaulian E, Vousden KH, Oren M. Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev 1995;9(17):2170-2183.

(28) Shaulian E, Haviv I, Shaul Y, Oren M. Transcriptional repression by the C-terminal domain of p53. Oncogene 1995;10(4):671-680.

(29) Telerman A, Tuynder M, Dupressoir T, Robaye B, Sigaux F, Shaulian E, et al. A model for tumor suppression using H-1 parvovirus. Proc Natl Acad Sci U S A 1993;90(18):8702-8706.

(30) Shaulian E, Zauberman A, Milner J, Davies EA, Oren M. Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation. EMBO J 1993;12(7):2789-2797.

(31) Shaulian E, Zauberman A, Ginsberg D, Oren M. Identification of a minimal transforming domain of p53: Negative dominance through abrogation of sequence-specific DNA binding. Mol Cell Biol 1992;12(12):5581-5592.