Skip to Main Content
It looks like you're using Internet Explorer 11 or older. This website works best with modern browsers such as the latest versions of Chrome, Firefox, Safari, and Edge. If you continue with this browser, you may see unexpected results.

The Faculty of Medicine - Biochemistry and Molecular Biology: Wiener Reuven

Researchers

 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Basu P, Elgrably-Weiss M, Hassouna F, Kumar M, Wiener R, Altuvia S. RNA binding of Hfq monomers promotes RelA-mediated hexamerization in a limiting Hfq environment. Nat Commun 2021;12(1).

(2) Banerjee S, Kumar M, Wiener R. Decrypting UFMylation: How proteins are modified with UFM1. Biomolecules 2020;10(10):1-14.

(3) Kumar M, Wiener R. Closing the gap of ubiquitin activation. Proc Natl Acad Sci U S A 2019;116(31):15319-15321.

(4) Babkoff A, Cohen-Kfir E, Aharon H, Ronen D, Rosenberg M, Wiener R, et al. A direct interaction between survivin and myosin II is required for cytokinesis. J Cell Sci 2019;132(14).

(5) Soudah N, Padala P, Hassouna F, Kumar M, Mashahreh B, Lebedev AA, et al. An N-Terminal Extension to UBA5 Adenylation Domain Boosts UFM1 Activation: Isoform-Specific Differences in Ubiquitin-like Protein Activation. J Mol Biol 2019;431(3):463-478.

(6) Mashahreh B, Reiss Y, Wiener R, Ravid T. Assays for dissecting the in vitro enzymatic activity of yeast Ubc7. Methods Enzymol 2019;619:71-95.

(7) Mashahreh B, Hassouna F, Soudah N, Cohen-Kfir E, Strulovich R, Haitin Y, et al. Trans-binding of UFM1 to UBA5 stimulates UBA5 homodimerization and ATP binding. FASEB J 2018;32(5):2794-2802.

(8) Hertzog BB, Kaufman Y, Biswas D, Ravins M, Ambalavanan P, Wiener R, et al. A Sub-population of Group A Streptococcus Elicits a Population-wide Production of Bacteriocins to Establish Dominance in the Host. Cell Host and Microbe 2018;23(3):312-323.e6.

(9) Padala P, Soudah N, Giladi M, Haitin Y, Isupov MN, Wiener R. The Crystal Structure and Conformations of an Unbranched Mixed Tri-Ubiquitin Chain Containing K48 and K63 Linkages. J Mol Biol 2017;429(24):3801-3813.

(10) Padala P, Oweis W, Mashahreh B, Soudah N, Cohen-Kfir E, Todd EA, et al. Novel insights into the interaction of UBA5 with UFM1 via a UFM1-interacting sequence. Sci Rep 2017;7(1).

(11) Wiener R, Vishnivetskiy SA, Gurevich VV, Hirsch JA. Phosphate sensor and construction of phosphorylation-independent arrestins. The Structural Basis of Arrestin Functions; 2017. p. 69-82.

(12) Attali I, Tobelaim WS, Persaud A, Motamedchaboki K, Simpson-Lavy KJ, Mashahreh B, et al. Ubiquitylation-dependent oligomerization regulates activity of Nedd4 ligases. EMBO J 2017;36(4):425-440.

(13) Oweis W, Padala P, Hassouna F, Cohen-Kfir E, Gibbs DR, Todd EA, et al. Trans-Binding Mechanism of Ubiquitin-like Protein Activation Revealed by a UBA5-UFM1 Complex. Cell Rep 2016;16(12):3113-3120.

(14) Baiady N, Padala P, Mashahreh B, Cohen-Kfir E, Todd EA, Du Pont KE, et al. The Vps27/Hrs/STAM (VHS) domain of the signaltransducing adaptor molecule (STAM) directs associated molecule with the SH3 domain of STAM (AMSH) specificity to longer ubiquitin chains and dictates the position of cleavage. J Biol Chem 2016;291(4):2033-2042.

(15) Cohen I, Wiener R, Reiss Y, Ravid T. Distinct activation of an E2 ubiquitin-conjugating enzyme by its cognate E3 ligases. Proc Natl Acad Sci U S A 2015;112(7):E625-E632.

(16) Ganoth A, Tsfadia Y, Wiener R. Ubiquitin: Molecular modeling and simulations. J Mol Graph Model 2013;46:29-40.

(17) Wiener R, Dibello AT, Lombardi PM, Guzzo CM, Zhang X, Matunis MJ, et al. E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1. Nat Struct Mol Biol 2013;20(9):1033-1039.

(18) Wiener R, Wolberger C. XA new DUB makes linear ubiquitin a party to its own destruction. Cell 2013;153(6):1189.

(19) Berndsen CE, Wiener R, Yu IW, Ringel AE, Wolberger C. A conserved asparagine has a structural role in ubiquitin-conjugating enzymes. Nat Chem Biol 2013;9(3):154-156.

(20) Wiener R, Zhang X, Wang T, Wolberger C. The mechanism of OTUB1-mediated inhibition of ubiquitination. Nature 2012;483(7391):618-622.

(21) Haitin Y, Wiener R, Shaham D, Peretz A, Cohen EB-, Shamgar L, et al. Intracellular domains interactions and gated motions of IKS potassium channel subunits. EMBO J 2009;28(14):1994-2005.

(22) Wiener R, Haitin Y, Shamgar L, Fernández-Alonso MC, Martos A, Chomsky-Hecht O, et al. The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interaction. J Biol Chem 2008;283(9):5815-5830.

(23) Shamgar L, Ma L, Schmitt N, Haitin Y, Peretz A, Wiener R, et al. Calmodulin is essential for cardiac IKS channel gating and assembly: Impaired function in long-QT mutations. Circ Res 2006;98(8):1055-1063.