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School of Pharmacy : Breuer Eli


 Last updated Septmber 2023 - School of Pharmacy

List of Publications


Reich R, Hoffman A, Suresh RR, Shai O, Frant J, Maresca A, et al. Carbamoylphosphonates inhibit autotaxin and metastasis formation in vivo. Journal of Enzyme Inhibition and Medicinal Chemistry [Internet]. 2015;30(5):767–72. Available from:


Veerendhar A, Cohen S, Frant J, Supuran CT, Reich R, Breuer E. Synthesis of Enantiomeric Aminoalkylcarbamoylphosphonates and Their Evaluation as Dual-Action Anticancer MMP and Carbonic Anhydrase Inhibitors. Heteroatom Chemistry [Internet]. 2015;26(4):257–69. Available from:


Reich R, Supuran CT, Breuer E. Tumor microenvironment as target in cancer therapy. Annual Reports in Medicinal Chemistry [Internet]. 2014;49:269–84. Available from:


Reich R, Hoffman A, Veerendhar A, Maresca A, Innocenti A, Supuran CT, et al. Carbamoylphosphonates control tumor cell proliferation and dissemination by simultaneously inhibiting carbonic anhydrase IX and matrix metalloproteinase-2. Toward nontoxic chemotherapy targeting tumor microenvironment(1). Journal of Medicinal Chemistry [Internet]. 2012;55(17):7875–82. Available from:


Frant J, Veerendhar A, Chernilovsky T, Nedvetzki S, Vaksman O, Hoffman A, et al. Orally Active, Antimetastatic, Nontoxic Diphenyl Ether-Derived Carbamoylphosphonate Matrix Metalloproteinase Inhibitors. ChemMedChem [Internet]. 2011;6(8):1471–7. Available from:


Harel E, Rubinstein A, Chen W, Breuer E, Tirosh B. Aminoalkylcarbamoylphosphonates reduce TNFα release from activated immune cells. Bioorganic and Medicinal Chemistry Letters [Internet]. 2010;20(22):6518–23. Available from:


Breuer E. Nitrones and nitronic acid derivatives: Their structure and their roles in synthesis [Internet]. Vol. 1, Supplement F: The Chemistry of Amino, Nitroso and Nitro Compounds and their Derivatives: Part 1. 2010. Available from:


Breuer E. Nitrones and nitronic acid derivatives: Their structure and their roles in synthesis [Internet]. Nitrones, Nitronates and Nitroxides. 2010. Available from:


Breuer E. Nitrones and nitronic acid derivatives: An update [Internet]. Nitrones, Nitronates and Nitroxides. 2010. Available from:


Breuer E, Aurich HU, Nielsen A, Patai S, Rappoport Z. Nitrones, Nitronates and Nitroxides [Internet]. Nitrones, Nitronates and Nitroxides. 2010. Available from:


Veerendhar A, Reich R, Breuer E. Phosphorus based inhibitors of matrix metalloproteinases. Comptes Rendus Chimie [Internet]. 2010;13(8–9):1191–202. Available from:


Breuer E, Chorghade MS, Fischer J, Golomb G. Glossary of terms related to pharmaceutics (IUPAC Recommendations 2009). Pure and Applied Chemistry [Internet]. 2009;81(5):971–99. Available from:


Hoffman A, Qadri B, Frant J, Katz Y, Bhusare SR, Breuer E, et al. Carbamoylphosphonate matrix metalloproteinase inhibitors 6: cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastatic matrix metalloproteinase-2 selective inhibitor - Synthesis and pharmacodynamic and pharmacokinetic analysis (Journal of Medicinal Chemistry (2008) 51, (1408)). Journal of Medicinal Chemistry [Internet]. 2008;51(14):4357–8. Available from:


Beylis I, Frant J, Mussai N, Reich R, Breuer E. Carbamoylphosphonates part 7. An efficient method for the synthesis of hindered carbamoylphosphonates using 4-nitrophenoxycarbonylphosphonate diesters. Tetrahedron Letters [Internet]. 2008;49(18):2875–7. Available from:


Hoffman A, Qadri B, Frant J, Katz Y, Bhusare SR, Breuer E, et al. Carbamoylphosphonate matrix metalloproteinase inhibitors 6: cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastatic matrix metalloproteinase-2 selective inhibitor-synthesis and pharmacodynamic and pharmacokinetic analysis. Journal of Medicinal Chemistry [Internet]. 2008;51(5):1406–14. Available from:


Augner S, Kehler J, Szakács Z, Breuer E, Hägele G. Ring-chain tautomerism and protolytic equilibria of 3-hydroxy-3- phosphonoisobenzofuranone studied by 1H, 13C and 31P NMR-controlled titrations. New Journal of Chemistry [Internet]. 2008;32(9):1608–16. Available from:


Munanairi A, O’Banion SK, Gamble R, Breuer E, Harris AW, Sandwick RK. The multiple Maillard reactions of ribose and deoxyribose sugars and sugar phosphates. Carbohydrate Research [Internet]. 2007;342(17):2575–92. Available from:


Huberman L, Gollop N, Mumcuoglu KY, Breuer E, Bhusare SR, Shai Y, et al. Antibacterial substances of low molecular weight isolated from the blowfly, Lucilia sericata. Medical and Veterinary Entomology [Internet]. 2007;21(2):127–31. Available from:


Breuer E. Fragmentations and rearrangements of α-hydroxyiminoalkylphosphonates. Current Organic Chemistry [Internet]. 2006;10(18):2357–70. Available from:


Skarpos H, Vorob’eva DV, Osipov SN, Odinets IL, Breuer E, Röschenthaler GV. Methyltrifluoropyruvate imines possessing N-oxalyl and N-phosphonoformyl groups - Precursors to a variety of α-CF3-α-amino acid derivatives. Organic and Biomolecular Chemistry [Internet]. 2006;4(19):3669–74. Available from:


Ta-Shma R, Torres A, Chevion M, Breuer E, Quntar AAA, Enk CD, et al. An autoxidation study of C2 substituted pyrimidine amino reductones. Tetrahedron [Internet]. 2006;62(23):5469–73. Available from:


Breuer E. The Development of Bisphosphonates as Drugs [Internet]. Analogue-based Drug Discovery. 2006. Available from:


Cohen S, Katz Y, Reich R, Breuer E. Trans-(4-Methylcyclohexylcarbamoyl)phosphonic acid: A representative matrix metalloproteinase (MMP) inhibitor. Acta Crystallographica Section E: Structure Reports Online [Internet]. 2005;61(9):o3008–10. Available from:


Reich R, Katz Y, Hadar R, Breuer E. Carbamoylphosphonate matrix metalloproteinase inhibitors 3: In vivo evaluation of cyclopentylcarbamoylphosphonic acid in experimental metastasis and angiogenesis. Clinical Cancer Research [Internet]. 2005;11(10):3925–9. Available from:


Breuer E, Frant J, Reich R. Recent non-hydroxamate matrix metalloproteinase inhibitors. Expert Opinion on Therapeutic Patents [Internet]. 2005;15(3):253–69. Available from:


Sandwick R, Johanson M, Breuer E. Maillard reactions of ribose 5-phosphate and amino acids. Annals of the New York Academy of Sciences [Internet]. 2005;1043:85–96. Available from:


Breuer E, Katz Y, Hadar R, Reich R. Carbamoylphosphonate MMP inhibitors. Part 4: The influence of chirality and geometrical isomerism on the potency and selectivity of inhibition. Tetrahedron Asymmetry [Internet]. 2004;15(15):2415–20. Available from:


Breuer E, Salomon CJ, Katz Y, Chen W, Lu S, Röschenthaler GV, et al. Carbamoylphosphonates, a new class of in vivo active matrix metalloproteinase inhibitors. 1. Alkyl- and cycloalkylcarbamoylphosphonic acids. Journal of Medicinal Chemistry [Internet]. 2004;47(11):2826–32. Available from:


Farkas E, Katz Y, Bhusare S, Reich R, Röschenthaler GV, Königsmann M, et al. Carbamoylphosphonate-based matrix metalloproteinase inhibitor metal complexes: Solution studies and stability constants. Towards a zinc-selective binding group. Journal of Biological Inorganic Chemistry [Internet]. 2004;9(3):307–15. Available from:


Sevenard DV, Loop I, Lork E, Breuer E, Röschenthaler GV. Dimer of trifluoropyruvic acid: Synthesis and molecular structure. Journal of Chemical Research - Part S [Internet]. 2003;(12):804–5. Available from:


Chen R, Breuer E. Intramolecular monodealkylation during the attempted synthesis of diethylphosphonoacetohydroxamic acid. Heteroatom Chemistry [Internet]. 2003;14(1):67–71. Available from:


Kadyrov AA, Silaev D, Breuer E, Röschenthaler GV. 1,1,3,3,3-Pentafluoro-2-pentafluorophenyl-1,2-epoxypropane and trimethylphosphite: Unusual 1,4-dioxan-2,5-dione ring formation. Journal of Fluorine Chemistry [Internet]. 2002;114(1):99–101. Available from:


Alferiev IS, Hinson JT, Ogle M, Breuer E, Levy RJ. High reactivity of alkyl sulfides towards epoxides under conditions of collagen fixation - A convenient approach to 2-amino-4-butyrolactones. Biomaterials [Internet]. 2001;22(18):2501–6. Available from:


Ta-Shma R, Schneider H, Mahajna M, Katzhendler J, Breuer E. A kinetic study of competing fragmentation and hydrolyses of phenyl hydrogen α-hydroxyiminobenzylphosphonate - A case of acid mediated inhibition of acid catalysis. Journal of the Chemical Society, Perkin Transactions 2 [Internet]. 2001;(8):1404–7. Available from:


Chen R, Schlossman A, Breuer E, Hagele G, Tillmann C, Van Gelder JM, et al. Long-chain functional bisphosphonates: synthesis, anticalcification, and antiresorption activity. Heteroatom Chemistry [Internet]. 2000;11(7):470–9. Available from:


Ezra A, Hoffman A, Breuer E, Alferiev IS, Mönkkönen J, El Hanany-Rozen N, et al. A peptide prodrug approach for improving bisphosphonate oral absorption. Journal of Medicinal Chemistry [Internet]. 2000;43(20):3641–52. Available from:


Katzhendler J, Schneider H, Ta-Shma R, Breuer E. Fragmentation of methyl hydrogen α-hydroxyiminobenzyl-phosphonates-kinetics, mechanism and the question of metaphosphate formation. Journal of the Chemical Society Perkin Transactions 2 [Internet]. 2000;(9):1961–8. Available from:


Salomon CJ, Breuer E. Facile “one-pot” preparation of phosphonothiolformates. Useful reagents for the synthesis of carbamoylphosphonates. Synlett [Internet]. 2000;(6):815–6. Available from:


Yaffe A, Golomb G, Breuer E, Binderman I. The effect of topical delivery of novel bisacylphosphonates in reducing alveolar bone loss in the rat model. Journal of Periodontology [Internet]. 2000;71(10):1607–12. Available from:


Grossmann G, Grossmann A, Ohms G, Breuer E, Chen R, Golomb G, et al. Solid-state NMR of bisphosphonates adsorbed on hydroxy apatite. Magnetic Resonance in Chemistry [Internet]. 2000;38(1):11–6. Available from:


Cohen H, Alferiev IS, Mönkkönen J, Seibel MJ, Pinto T, Ezra A, et al. Synthesis and preclinical pharmacology of 2-(2-aminopyrimidinio) ethylidene-1,1-bisphosphonic acid betaine (ISA-13-1)-a novel bisphosphonate. Pharmaceutical Research [Internet]. 1999;16(9):1399–406. Available from:


Patlas N, Golomb G, Yaffe P, Pinto T, Breuer E, Ornoy A. Transplacental effects of bisphosphonates on fetal skeletal ossification and mineralization in rats. Teratology [Internet]. 1999;60(2):68–73. Available from:


Yaffe A, Binderman I, Breuer E, Pinto T, Golomb G. Disposition of alendronate following local delivery in a rat jaw. Journal of Periodontology [Internet]. 1999;70(8):893–5. Available from:


Chen R, Breuer E. Direct Approach to α-Hydroxyphosphonic and α,ω-Dihydroxyalkane-α,ω-bisphosphonic Acids by the Reduction of (Bis)acylphosphonic Acids. Journal of Organic Chemistry [Internet]. 1998;63(15):5107–9. Available from:


Cohen H, Solomon V, Alferiev IS, Breuer E, Ornoy A, Patlas N, et al. Bisphosphonates and tetracycline: Experimental models for their evaluation in calcium-related disorders. Pharmaceutical Research [Internet]. 1998;15(4):606–13. Available from:


Klein BY, Ben-Bassat H, Breuer E, Solomon V, Golomb G. Structurally different bisphosphonates exert opposing effects on alkaline phosphatase and mineralization in marrow osteoprogenitors. Journal of Cellular Biochemistry [Internet]. 1998;68(2):186–94. Available from:


Il’Yasov AV, Vafina AA, Breuer E, Hägele G. ESR study of some iminoxy free radicals generated from phosphorylated oximes and dioximes. Applied Magnetic Resonance [Internet]. 1998;14(4):489–96. Available from:


Ezra A, Hoffman A, Breuer E, Weiss G, Golomb G. Proteins: Carrier-mediated absorption of bisphosphonate prodrugs. Proceedings of the Controlled Release Society [Internet]. 1998;(25):473–4. Available from:


Kehler J, Breuer E. 3-Chloro-3-(dimethoxyphosphoryl)isobenzofuran-1(3H)-one - A new reagent for the rapid, convenient phthaloylation of amines and amino acids in high yields. Synthesis [Internet]. 1998;(10):1419–20. Available from:


Mathew M, Fowler BO, Breuer E, Golomb G, Alferiev IS, Eidelman N. Synthesis, Characterization, and Crystal Structure of Dicalcium Glutarylbis(phosphonate) Dihydrate: A Covalently Pillared Layer Structure with the Potential for Epitaxial Growth on Hydroxyapatite. Inorganic Chemistry [Internet]. 1998;37(25):6485–94. Available from:


Van Gelder JM, Breuer E, Schlossman A, Ornoy A, Mönkkönen J, Similä J, et al. In vitro and in vivo effects of tetrakisphosphonates on bone resorption, tumor osteolysis, ectopic calcification, and macrophages. Journal of Pharmaceutical Sciences [Internet]. 1997;86(3):283–9. Available from:


Kehler J, Breuer E. Unusual solvent-dependent behaviour of hydroxyiminophosphonamidates in the Beckmann reactions: Choice between rearrangement or fragmentation to metaphosphonamidate species. Chemical Communications [Internet]. 1997;(18):1751–2. Available from:


Schoth RM, Lork E, Seifert FU, Breuer E, Röschenthaler GV. Preparation of methyl 2-[Bis(trimethylsiloxy)phosphoryl]-3,3,3-trifluoro-2-(trimethylsiloxy)propionate and some derivatives -molecular structure of methyl 2-[bis(trimethylsiloxy)phosphoryl]-3,3,3-trifluoro-2-hydroxypropionate. Chemische Berichte [Internet]. 1997;130(2):279–81. Available from:


Ezra A, Hoffman A, Breuer E, Weiss G, Lipka E, Amidon GL, et al. Peptidyl prodrugs for improved oral absorption. Proceedings of the Controlled Release Society [Internet]. 1997;(24):243–4. Available from:


Salomon CJ, Breuer E. Spontaneous Lossen Rearrangement of (Phosphonoformyl)hydroxamates. The Migratory Aptitude of the Phosphonyl Group. Journal of Organic Chemistry [Internet]. 1997;62(12):3858–61. Available from:


Katzhendler J, Ringel I, Karaman R, Zaher H, Breuer E. Acylphosphonate hemiketals - Formation rate and equilibrium. The electron-withdrawing effect of dimethoxyphosphinyl group. Journal of the Chemical Society Perkin Transactions 2 [Internet]. 1997;(2):341–9. Available from:


Skrtic D, Eidelman N, Golomb G, Breuer E, Eanes ED. In vitro inhibition of membrane-mediated calcification by novel phosphonates. Calcified Tissue International [Internet]. 1996;58(5):347–54. Available from:


Schoth RM, Lork E, Seifert FU, Röschenthaler GV, Cohen H, Golomb G, et al. Routes to F3-Etidronic Acid (1-Hydroxy-2,2,2-Trifluoroethylidene-Bisphosphonic Acid), Molecular Structure of the Tris(trimethylsilyl)ester, Antimineralization, and Antiresorption Effects of the Disodium Salt. Naturwissenschaften [Internet]. 1996;83(12):571–4. Available from:


Golomb G, Van Gelder JM, Alferiev IS, Ornoy A, Hoffman A, Schlossman A, et al. Novel bisphosphonates for calcium-related disorders. Phosphorus, Sulfur and Silicon and Related Elements [Internet]. 1996;109(1–4):221–4. Available from:


Il’yasov A, Breuer E, Hagele G, Vafina A, Liorber B. NMR and ESR study of phosphorylated oximes and iminoxy radicals. Phosphorus, Sulfur and Silicon and Related Elements [Internet]. 1996;109(1–4):437–40. Available from:


Ezra A, Breuer E, Amidon G, Hoffman A, Ornoy A, Patlas N, et al. Peptidyl prodrug of bisphosphonates for improved oral absorption. Proceedings of the Controlled Release Society [Internet]. 1996;(23):83–4. Available from:


Breuer E, Zaher H, Tashma Z, Gibson D. Acylphosphonamidates and α-hydroxyiminophosphonamidates. Synthesis of N-acylphosphordiamidates by Beckmann rearrangement. Crystal structure of (E)-α-hydroxyiminobenzyl-1-pyrrolidinylphosphinate. Heteroatom Chemistry [Internet]. 1996;7(6):515–20. Available from:


Salomon CJ, Breuer E. Efficient and selective dealkylation of phosphonate dilsopropyl esters using Me3SiBr. Tetrahedron Letters [Internet]. 1995;36(37):6759–60. Available from:


Van Gelder JM, Breuer E, Ornoy A, Schlossman A, Patlas N, Golomb G. Anticalcification and antiresorption effects of bisacylphosphonates. Bone [Internet]. 1995;16(5):511–20. Available from:


Mahajna M, Breuer E. 2-Cyanoethyl and p-nitrophenethyl α-hydroxyimino- and α-methoxyimino-phosphonates: Potential precursors of metaphosphate anion. Journal of the Chemical Society, Perkin Transactions 1 [Internet]. 1994;(13):1847–9. Available from:


Breuer E, Karaman R, Zaher H, Katz E. Synthesis of some acylphosphonate thiosemicarbazones and evaluation of their antiviral activity. Drug Design and Discovery [Internet]. 1994;11(1):39–46. Available from:


Breuer E, Golomb G, Hoffman A, Schlossman A, Van Gelder JM, Saadeh H, et al. In Vitro and In Vivo Inhibition of Hydroxyapatite Formation and Dissolution by Bisacylphosphonates and Bishydroxyiminophosphonates. Phosphorus, Sulfur, and Silicon and the Related Elements [Internet]. 1993;76(1–4):167–70. Available from:


Mahajna M, Breuer E. Thermal Fragmentation of Trihaloethyl and Hexafluoro-2-propyl (α-Hydroxyiminobenzyl)phosphonates. Solvent Effects and the Trapping of Metaphosphate. Journal of Organic Chemistry [Internet]. 1993;58(27):7822–6. Available from:


Karle JM, Karle IL, Leader H, Breuer E, Newman AH, Gordon RK, et al. Relationship of the crystal structure of γ-N,N-dimethylaminopropyl 2,2-diphenylpropionate hydrochloride to antimuscarinic activity. Journal of Crystallographic and Spectroscopic Research [Internet]. 1992;22(4):485–91. Available from:


Breuer E, Zaher H, Tashma Z. Beckmann rearrangement of N-(α-hydroxyiminoalkylphosphonyl)amino acids. A convenient synthetic approach to novel peptide-transition-state analogs. Tetrahedron Letters [Internet]. 1992;33(15):2067–8. Available from:


Breuer E, Mahajna M. Synthesis and reactions of 2,2,2‐trihaloethyl α‐hydroxyiminobenzylphosphonates. The influence of the ester group on the chemistry of phosphonates. Heteroatom Chemistry [Internet]. 1992;3(3):251–60. Available from:


Bentolila A, Katzhendler J, Breuer E. The reaction of benzoylphosphonic acid with thionyl chloride. the formation of benzoylphosphonic dichloride and P, P’- dibenzoylpyrophosphonic dichloride. Phosphorus, Sulfur, and Silicon and the Related Elements [Internet]. 1992;70(1–4):109–12. Available from:


Golomb G, Schlossman A, Eitan Y, Saadeh H, Van Gelder JM, Breuer E. In vitro and in vivo anticalcification effects of novel bishydroxyiminophosphonates. Journal of Pharmaceutical Sciences [Internet]. 1992;81(10):1004–7. Available from:


Golomb G, Schlossman A, Saadeh H, Levi M, Van Gelder JM, Breuer E. Bisacylphosphonates Inhibit Hydroxyapatite Formation and Dissolution in Vitro and Dystrophic Calcification in Vivo. Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists [Internet]. 1992;9(1):143–8. Available from:


Breuer E, Safadi M, Chorev M, Gibson D. Evaluation of the n-phthaloyl moiety as protecting group in aminoacylphosphonic derivatives. Phosphorus, Sulfur, and Silicon and the Related Elements [Internet]. 1991;60(3–4):239–46. Available from:


Breuer E, Mahajna M, Quin LD, Quin GS. Photoinduced Phosphorylation by [α-(Hydroxyimino)benzyl]phosphonates through Fragmentation to Monomeric Metaphosphates. Journal of Organic Chemistry [Internet]. 1991;56(15):4791–3. Available from:


Breuer E, Safadi M, Chorev M, Vineze A, Bel P. Synthesis and characterization of amino protected peptides derived from amino-α- hydroxyiminophosphonates. Tetrahedron [Internet]. 1991;47(7):1257–64. Available from:


Safadi M, Chorev M, Breuer E. Aminoacylphosphonates—novel modified amino acid derivatives. Phosphorus, Sulfur, and Silicon and the Related Elements [Internet]. 1990;51(1–4):396. Available from:


Schlossman A, Gibson D, Breuer E. Rearrangement and fragmentation reactions of α-hydroxyiminophoshinates. On the nature of the metaphosphonate intermediate involved in phosphonylations by α-hydroxyiminophosphinate. Phosphorus, Sulfur, and Silicon and the Related Elements [Internet]. 1990;49–50(1–4):81–4. Available from:


Breuer E, Schlossman A, Safadi M, Gibson D, Chorev M, Leader H. Stereoselectivity in fragmentation and rearrangement of α-hydroxyimino-phosphinates and -phosphonates. A synthetic approach to acylphosphon- and phosphor-amidates. Crystal structures of methyl (E)-α-hydroxyimino-benzylphenylphosphinate and methyl benzoylphenylphosphonamidate. Journal of the Chemical Society, Perkin Transactions 1 [Internet]. 1990;(12):3263–9. Available from:


Breuer E, Safadi M, Chorev M, Gibson D. Novel Amino Acid Derivatives. Preparation and Properties of Aminoacylphosphonates and Amino Hydroxyimino Phosphonates. Journal of Organic Chemistry [Internet]. 1990;55(25):6147–53. Available from:


Quin LD, Wu XP, Breuer E, Mahajna M. The mechanism of fragmentation of alkyl α-(oxyimino)benzylphosphonates; use of silica gel as a novel hydroxylic trapping reactant for an intermediate alkyl metaphosphate. Tetrahedron Letters [Internet]. 1990;31(44):6281–2. Available from:


Breuer E, Karaman R, Goldblum A, Gibson D, Leader H, Potter BVL, et al. Erratum: α-Oxyiminophosphonates: Chemical and physical properties. Reactions, theoretical calculations and crystal structures of (E)- And (Z)-dimethyl α-Hydroxyiminobenzylphosphonates (Journal of the Chemical Society, Perkin Transactions 1 (1988) 3047). Journal of the Chemical Society, Perkin Transactions 1 [Internet]. 1989;(7):1367. Available from:


Breuer E, Karaman R, Gibson D, Goldblum A. Structure and reactivity of 2-hydroxyiminobenzyl-2-oxo-4,4,5,5-tetramethyl[1,3,2]dioxaphospholanes. Phosphorus, Sulfur, and Silicon and the Related Elements [Internet]. 1989;41(3–4):433–7. Available from:


Katzhendler J, Karaman R, Gibson D, Breuer E, Leader H. Fragmentation of methyl hydrogen α-hydroxyiminophosphonates to monomeric methyl metaphosphate: Stereochemistry and mechanism. Journal of the Chemical Society, Perkin Transactions 2 [Internet]. 1989;(6):589–94. Available from:


Karaman R, Goldblum A, Breuer E, Leader H. Acylphosphonic acids and methyl hydrogen acylphosphonates: Physical and chemical properties and theoretical calculations. Journal of the Chemical Society, Perkin Transactions 1 [Internet]. 1989;(4):765–74. Available from:


Gordon RK, Smejkal RM, Breuer E, Chiang PK. Design and synthesis of antimuscarinics based on physical and mechanical attributes. Progress in clinical and biological research [Internet]. 1989;289:465–70. Available from:


Gordon RK, Breuer E, Padilla FN, Smejkal RM, Chiang PK. Distance geometry of α-substituted 2,2-diphenylpropionate antimuscarinics. Molecular Pharmacology [Internet]. 1989;36(5):766–72. Available from:


Breuer E, Karaman R, Goldblum A, Gibson D, Leader H, Potter BVL, et al. α-Oxyiminophosphonates: Chemical and physical properties. Reactions, theoretical calculations, and x-ray crystal structures of (E) and (Z)-dimethyl α-hydroxyiminobenzylphosphonates. Journal of the Chemical Society, Perkin Transactions 1 [Internet]. 1988;(11):3047–57. Available from:


Breuer E, Karaman R, Gibson D, Leader H, Goldblum A. α-hydroxyiminophosphonic acids. New types of phosphorylating agents through monomeric metaphosphate. Journal of the Chemical Society, Chemical Communications [Internet]. 1988;(7):504–6. Available from:


Breuer E, Karaman R, Goldblum A, Leader H. Sulphonic acid-induced fragmentation of dialkyl acylphosphonates, formation of alkyl carboxylates and alkyl sulphonates. Journal of the Chemical Society, Perkin Transactions 2 [Internet]. 1988;(12):2029–34. Available from:


Brown ND, Smejkal RM, Breuer E, Doctor BP, Chiang PK. Desethylaprophen: A metabolite of aprophen with antimuscarinic activities. Journal of Pharmaceutical Sciences [Internet]. 1988;77(2):145–8. Available from:


Breuer E, Karaman R, Leader H, Goldblum A. Phosphorylation of alcohols through the acid-catalysed fragmentation of α-oxyiminophosphonates. Journal of the Chemical Society, Chemical Communications [Internet]. 1987;(9):671–2. Available from:


Breuer E, Moshe R. Stereoselectivity in the Wittig‐Horner‐Emmons Synthesis of Vinylphosphonates by the Reaction of Acylphosphonates with Acyclic or Heterocyclic Phosphonoacetates. Israel Journal of Chemistry [Internet]. 1986;27(1):45–7. Available from:


Bottin-Strzalko T, Seyden-Penne J, Breuer E, Pouet MJ, Simonnin MP. Wittig-Horner reagents: Structural and conformational study of five- and six-membered cyclic phosphonates and their carbanions. Evidence of anomeric effect in anionic species. Journal of the Chemical Society, Perkin Transactions 2 [Internet]. 1985;(11):1801–5. Available from:


Breuer E, Melumad D, Sarel S. Antiviral compounds. 2. The preparation and activity of some substituted 3-methyl-1-phenyl-5-pyrazolones. European Journal of Medicinal Chemistry [Internet]. 1983;18(6):481–5. Available from:


Breuer E, Melumad D, So S, Katz E. Antiviral compounds. 3. The preparation of some diketophosphonates derived from sugars. European Journal of Medicinal Chemistry [Internet]. 1983;18(6):487–8. Available from:


Breuer E, Melumad D, Sarel S, Margalith E, Katz E. Antiviral Compounds. 1. Structure-Activity Relationship of Some Antiviral Enediones Derived from Aldehydo Sugars. Journal of Medicinal Chemistry [Internet]. 1983;26(1):30–4. Available from:


Breuer E, Deutsch J, Lazarovici P. A practical synthesis of the aggregation pheromone of Tribolium castaneum and Tribolium confusum. Chemistry and Industry (London) [Internet]. 1982;No. 22:907–8. Available from:


Zbaida S, Breuer E. Nitrones. 6. Reactions of Nitrones with Cyclic Phosphonates. Influence of the Phosphonate Ring Size upon the Course of the Reaction. Journal of Organic Chemistry [Internet]. 1982;47(6):1073–7. Available from:


Noam M, Tamir I, Breuer E, Mechoulam R. Conversion of ruscogenin into 1α- and 1β hydroxycholesterol derivatives. Structure elucidation by computer assisted analysis of their lanthanide-induced nmr shifts. Tetrahedron [Internet]. 1981;37(3):597–604. Available from:


Zbaida S, Breuer E. Observation of pentacoordinated phosphorus intermediate in the reactions of nitrones with phosphonate anions. Experientia [Internet]. 1979;35(7):851–2. Available from:


Golander Y, Breuer E, Sarel S. Syntheses of Some Norcholanylisoquinoline Derivatives. Archiv der Pharmazie [Internet]. 1979;312(4):319–24. Available from:


Golander Y, Breuer E, Sarel S. Synthesis of some 2′‐(3‐Oxopregn‐4‐en‐20‐yl)oxazolidines and ‐thiazolidines. Archiv der Pharmazie [Internet]. 1979;312(3):192–8. Available from:


Zbáida S, Breuer E. Nitrones-V1 1 Part IV: E. Breuer and S. Zbaida, J. Org. Chem. 42, 1904 (1977). Reactions of some nitrones with phosphinoxy ylids. Tetrahedron [Internet]. 1978;34(8):1241–5. Available from:


Zbaida S, Breuer E. Effect of ring size in cyclic phosphonates upon their reaction with nitrones. Journal of the Chemical Society, Chemical Communications [Internet]. 1978;(1):6–7. Available from:


Breuer E, Bannet DM. The preparation of some cyclic phosphonates and their use in olefin synthesis. Tetrahedron [Internet]. 1978;34(7):997–1002. Available from:


Breuer E, Zbaida S. Nitrones. 4. Reactions of Δ1-Pyrroline N-Oxides with Phosphonates. Alternative Formation of Aziridines and Enamines. Journal of Organic Chemistry [Internet]. 1977;42(11):1904–10. Available from:


Golander Y, Breuer E, Sarel S. Synthesis of a Steroidal Dicarbamate Related to Meprobamate from 3‐Ketobisnorcholenal. Israel Journal of Chemistry [Internet]. 1977;16(1):25–7. Available from:


Breuer E, Somekh L, Ringel I. N.m.r. spectra of cyclic amines. II—Factors influencing the chemical shifts of α‐protons in aziridines. Organic Magnetic Resonance [Internet]. 1977;9(6):328–32. Available from:


Breuer E, Zbaida S, Pesso J, Ronen-Braunstein I. Nitrones-III1 1 Part II: E. Breuer, S. Zbaida, J. Pesso and S. Levi, Tetrahedron Letters 3104 (1975). Reaction of 3,4-dihydroisoquinoline n-oxide with phosphonoylids. Tetrahedron [Internet]. 1977;33(10):1145–8. Available from:


Breuer E, Bannet DM. Stereoselectivity of wittig type olefin synthesis using five-membered cyclic phosphonates. preferential formation of cis olefins. Tetrahedron Letters [Internet]. 1977;18(13):1141–4. Available from:


Breuer E, Zbaida S. The synthesis of shihunine and related compounds from ortho-carboxyphenyl cyclopropyl ketone. Tetrahedron [Internet]. 1975;31(6):499–504. Available from:


Breuer E, Zbaida S, Pesso J, Levi S. Nitrones II. Dualistic behaviour in the reaction of phosphonates with nitrones. Alternative formation of aziridines and enamines. Tetrahedron Letters [Internet]. 1975;16(35):3103–4. Available from:


Breuer E, Zbaida S. The Synthesis of Shihunine Via the Cyclopropyl Ketimine + Pyrroline Rearrangement. Synthetic Communications [Internet]. 1974;4(1):21–4. Available from:


Breuer E, Ronen-Braunstein I. Reaction of a nitrone with a phosphono-ylide. A novel approach to aziridines. Journal of the Chemical Society, Chemical Communications [Internet]. 1974;(22):949. Available from:


Breuer E, Melumad D. Nuclear Magnetic Resonance Spectra of Cyclic Amines. Shielding of αProtons Trans to a Lone Pair and Cis to an N-Methyl Group in Pyrrolidines. Journal of Organic Chemistry [Internet]. 1973;38(8):1601–2. Available from:


Breuer E, Segall E, Stein Y, Sarel S. Ring Opening in the Hydroboration of Vinylcyclopropane Systems. a Cyclopropylcarbinyl-Allylcarbinylborane Rearrangement. Journal of Organic Chemistry [Internet]. 1972;37(14):2242–5. Available from:


Breuer E, Brown HC, Breuer E. Organoboranes. VIII. Structure of the Thermally Isomerized Organoborane from the Reaction of Borane and 1,3-Butadiene in a 1:1 Molar Ratio. Evidence for an Exceptionally Stable Transannular Boron-Hydrogen Bridge. Journal of the American Chemical Society [Internet]. 1969;91(15):4164–9. Available from:


Breuer E, Melumad D. A one-step synthesis of nicotine from cyclopropyl 3-pyridyl ketone. Tetrahedron Letters [Internet]. 1969;10(41):3595–6. Available from:


Breuer E, Melumad D. The reaction of o-quinone methides with dimethyl sulfoxonium methylide. A simple synthesis of coumarans. Tetrahedron Letters [Internet]. 1969;10(23):1875–7. Available from:


Breuer E, Berger T, Sarel S. Rearrangement of an α-halogenoamides to carbamates by alkoxides. Chemical Communications (London) [Internet]. 1968;(24):1596–7. Available from:


Breuer E, Sarel S, Taube A, Sharvit J. Structure Determination of Derivatives of α‐Amino‐α, α‐Diphenylacetamide by Mass Spectrometry. Israel Journal of Chemistry [Internet]. 1968;6(5):777–85. Available from:


Breuer E, Stein Y. Reactions of Cyclopropane Derivatives with Nitrogen Compounds, I. The Synthesis of Pyrrolidines by the Leuckart Reaction of Cyclopropyl Ketones. Israel Journal of Chemistry [Internet]. 1968;6(6):901–8. Available from:


Breuer E, Sarel S. Homoallylic rearrangement of cyclopropylcarbinyl borates. A stereospecific synthesis of trans-4-aryl-3-butenols. Tetrahedron [Internet]. 1968;24(21):6339–49. Available from:


Breuer E. The hydrogenolysis of some cyclopropyl ketones and cyclopropyl carbinols with diborane and borontrifluoride. Tetrahedron Letters [Internet]. 1967;8(20):1849–54. Available from:


Sarel S, Breuer E, Klug JT, Fattal Y. Rearrangement and Fragmentation of Pentaphenylazetidinone. Israel Journal of Chemistry [Internet]. 1966;4(5–6):233–7. Available from:


Brown HC, Heydkamp WR, Breuer E, Murphy WS. The Reaction of Organoboranes with Chloramine and with Hydroxylamine-O-sulfonic Acid. A Convenient Synthesis of Amines from Olefins via Hydroboration. Journal of the American Chemical Society [Internet]. 1964;86(17):3565–6. Available from:


Sarel S, Klug JT, Breuer E, D’Angeli F. α-haloamide reactions. III. The reaction of α-chloro-α-α-diphenylacetanilide with sodium hydride. Tetrahedron Letters [Internet]. 1964;5(24):1553–6. Available from:


Sarel S, Breuer E, Ertag Sh, Salamon R. Polar Effects in the Homoallylic Rearrangement of Arylcyclopropylcarbinols. Israel Journal of Chemistry [Internet]. 1963;1(4):451–9. Available from:


Sarel S, Breuer ELI, Menahem JS. A tracer study of the hydrolysis of ethyl ββ-diethoxyacrylate. Journal of the Chemical Society (Resumed) [Internet]. 1963;66–9. Available from:


Sarel S, Breuer E. A Novel Conjugative 1,5-Addition Reaction Involving The Vinylcyclopropane System. Journal of the American Chemical Society [Internet]. 1959;81(24):6522–3. Available from:


Bergmann F, Kalmus A, Breuer E. β-Fluorostyrene. Journal of the American Chemical Society [Internet]. 1958;80(17):4540–3. Available from:


Bergmann F, Kalmus A, Breuer E. ω-Fluoroacetophenone. III. Reaction of Fluoroacetyl Chloride with Halobenzenes. On the Mechanism of Side-chain Chlorination by Sulfuryl Chloride. Journal of the American Chemical Society [Internet]. 1957;79(15):4178–81. Available from: