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School of Pharmacy : Breuer Eli


 Last updated December 2021 - School of Pharmacy

List of Publications

(1) Reich R, Hoffman A, Suresh RR, Shai O, Frant J, Maresca A, et al. Carbamoylphosphonates inhibit autotaxin and metastasis formation in vivo. J Enzyme Inhib Med Chem 2015;30(5):767-772.

(2) Veerendhar A, Cohen S, Frant J, Supuran CT, Reich R, Breuer E. Synthesis of Enantiomeric Aminoalkylcarbamoylphosphonates and Their Evaluation as Dual-Action Anticancer MMP and Carbonic Anhydrase Inhibitors. Heteroatom Chem 2015;26(4):257-269.

(3) Reich R, Supuran CT, Breuer E. Tumor microenvironment as target in cancer therapy. Annu Rep Med Chem 2014;49:269-284.

(4) Reich R, Hoffman A, Veerendhar A, Maresca A, Innocenti A, Supuran CT, et al. Carbamoylphosphonates control tumor cell proliferation and dissemination by simultaneously inhibiting carbonic anhydrase IX and matrix metalloproteinase-2. Toward nontoxic chemotherapy targeting tumor microenvironment(1). J Med Chem 2012;55(17):7875-7882.

(5) Frant J, Veerendhar A, Chernilovsky T, Nedvetzki S, Vaksman O, Hoffman A, et al. Orally Active, Antimetastatic, Nontoxic Diphenyl Ether-Derived Carbamoylphosphonate Matrix Metalloproteinase Inhibitors. ChemMedChem 2011;6(8):1471-1477.

(6) Harel E, Rubinstein A, Chen W, Breuer E, Tirosh B. Aminoalkylcarbamoylphosphonates reduce TNFα release from activated immune cells. Bioorg Med Chem Lett 2010;20(22):6518-6523.

(7) Breuer E. Nitrones and nitronic acid derivatives: Their structure and their roles in synthesis. Supplement F: The Chemistry of Amino, Nitroso and Nitro Compounds and their Derivatives: Part 1; 2010. p. 459-564.

(8) Breuer E. Nitrones and nitronic acid derivatives: Their structure and their roles in synthesis. Nitrones, Nitronates and Nitroxides; 2010. p. 139-244.

(9) Breuer E. Nitrones and nitronic acid derivatives: An update. Nitrones, Nitronates and Nitroxides; 2010. p. 245-312.

(10) Breuer E, Aurich HU, Nielsen A, Patai S, Rappoport Z. Nitrones, Nitronates and Nitroxides. Nitrones, Nitronates and Nitroxides; 2010. p. 1-435.

(11) Veerendhar A, Reich R, Breuer E. Phosphorus based inhibitors of matrix metalloproteinases. C R Chim 2010;13(8-9):1191-1202.

(12) Breuer E, Chorghade MS, Fischer J, Golomb G. Glossary of terms related to pharmaceutics (IUPAC Recommendations 2009). Pure Appl Chem 2009;81(5):971-999.

(13) Hoffman A, Qadri B, Frant J, Katz Y, Bhusare SR, Breuer E, et al. Carbamoylphosphonate matrix metalloproteinase inhibitors 6: cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastatic matrix metalloproteinase-2 selective inhibitor - Synthesis and pharmacodynamic and pharmacokinetic analysis (Journal of Medicinal Chemistry (2008) 51, (1408)). J Med Chem 2008;51(14):4357-4358.

(14) Beylis I, Frant J, Mussai N, Reich R, Breuer E. Carbamoylphosphonates part 7. An efficient method for the synthesis of hindered carbamoylphosphonates using 4-nitrophenoxycarbonylphosphonate diesters. Tetrahedron Lett 2008;49(18):2875-2877.

(15) Hoffman A, Qadri B, Frant J, Katz Y, Bhusare SR, Breuer E, et al. Carbamoylphosphonate matrix metalloproteinase inhibitors 6: cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastatic matrix metalloproteinase-2 selective inhibitor-synthesis and pharmacodynamic and pharmacokinetic analysis. J Med Chem 2008;51(5):1406-1414.

(16) Augner S, Kehler J, Szakács Z, Breuer E, Hägele G. Ring-chain tautomerism and protolytic equilibria of 3-hydroxy-3- phosphonoisobenzofuranone studied by 1H, 13C and 31P NMR-controlled titrations. New J Chem 2008;32(9):1608-1616.

(17) Huberman L, Gollop N, Mumcuoglu KY, Breuer E, Bhusare SR, Shai Y, et al. Antibacterial substances of low molecular weight isolated from the blowfly, Lucilia sericata. Med Vet Entomol 2007;21(2):127-131.

(18) Breuer E. Fragmentations and rearrangements of α-hydroxyiminoalkylphosphonates. Curr Org Chem 2006;10(18):2357-2370.

(19) Skarpos H, Vorob'eva DV, Osipov SN, Odinets IL, Breuer E, Röschenthaler G-. Methyltrifluoropyruvate imines possessing N-oxalyl and N-phosphonoformyl groups - Precursors to a variety of α-CF3-α-amino acid derivatives. Org Biomol Chem 2006;4(19):3669-3674.

(20) Ta-Shma R, Torres A, Chevion M, Breuer E, Quntar AAA, Enk CD, et al. An autoxidation study of C2 substituted pyrimidine amino reductones. Tetrahedron 2006;62(23):5469-5473.

(21) Breuer E. The Development of Bisphosphonates as Drugs. Analogue-based Drug Discovery; 2006. p. 371-384.

(22) Cohen S, Katz Y, Reich R, Breuer E. Trans-(4-Methylcyclohexylcarbamoyl)phosphonic acid: A representative matrix metalloproteinase (MMP) inhibitor. Acta Crystallogr Sect E Struct Rep Online 2005;61(9):o3008-o3010.

(23) Reich R, Katz Y, Hadar R, Breuer E. Carbamoylphosphonate matrix metalloproteinase inhibitors 3: In vivo evaluation of cyclopentylcarbamoylphosphonic acid in experimental metastasis and angiogenesis. Clin Cancer Res 2005;11(10):3925-3929.

(24) Breuer E, Frant J, Reich R. Recent non-hydroxamate matrix metalloproteinase inhibitors. Expert Opin Ther Pat 2005;15(3):253-269.

(25) Breuer E, Katz Y, Hadar R, Reich R. Carbamoylphosphonate MMP inhibitors. Part 4: The influence of chirality and geometrical isomerism on the potency and selectivity of inhibition. Tetrahedron Asymmetry 2004;15(15):2415-2420.

(26) Breuer E, Salomon CJ, Katz Y, Chen W, Lu S, Röschenthaler G-, et al. Carbamoylphosphonates, a new class of in vivo active matrix metalloproteinase inhibitors. 1. Alkyl- and cycloalkylcarbamoylphosphonic acids. J Med Chem 2004;47(11):2826-2832.

(27) Farkas E, Katz Y, Bhusare S, Reich R, Röschenthaler G-, Königsmann M, et al. Carbamoylphosphonate-based matrix metalloproteinase inhibitor metal complexes: Solution studies and stability constants. Towards a zinc-selective binding group. J Biol Inorg Chem 2004;9(3):307-315.

(28) Sevenard DV, Loop I, Lork E, Breuer E, Röschenthaler G-. Dimer of trifluoropyruvic acid: Synthesis and molecular structure. J Chem Res Part S 2003(12):804-805.

(29) Chen R, Breuer E. Intramolecular monodealkylation during the attempted synthesis of diethylphosphonoacetohydroxamic acid. Heteroatom Chem 2003;14(1):67-71.

(30) Kadyrov AA, Silaev D, Breuer E, Röschenthaler G-. 1,1,3,3,3-Pentafluoro-2-pentafluorophenyl-1,2-epoxypropane and trimethylphosphite: Unusual 1,4-dioxan-2,5-dione ring formation. J Fluor Chem 2002;114(1):99-101.

(31) Alferiev IS, Hinson JT, Ogle M, Breuer E, Levy RJ. High reactivity of alkyl sulfides towards epoxides under conditions of collagen fixation - A convenient approach to 2-amino-4-butyrolactones. Biomaterials 2001;22(18):2501-2506.

(32) Ta-Shma R, Schneider H, Mahajna M, Katzhendler J, Breuer E. A kinetic study of competing fragmentation and hydrolyses of phenyl hydrogen α-hydroxyiminobenzylphosphonate - A case of acid mediated inhibition of acid catalysis. J Chem Soc Perkin Trans 2 2001(8):1404-1407.

(33) Chen R, Schlossman A, Breuer E, Hagele G, Tillmann C, Van Gelder JM, et al. Long-chain functional bisphosphonates: synthesis, anticalcification, and antiresorption activity. Heteroatom Chem 2000;11(7):470-479.

(34) Ezra A, Hoffman A, Breuer E, Alferiev IS, Mönkkönen J, El Hanany-Rozen N, et al. A peptide prodrug approach for improving bisphosphonate oral absorption. J Med Chem 2000;43(20):3641-3652.

(35) Katzhendler J, Schneider H, Ta-Shma R, Breuer E. Fragmentation of methyl hydrogen α-hydroxyiminobenzyl-phosphonates-kinetics, mechanism and the question of metaphosphate formation. J Chem Soc Perkin Trans 2 2000(9):1961-1968.

(36) Salomon CJ, Breuer E. Facile 'one-pot' preparation of phosphonothiolformates. Useful reagents for the synthesis of carbamoylphosphonates. Synlett 2000(6):815-816.

(37) Yaffe A, Golomb G, Breuer E, Binderman I. The effect of topical delivery of novel bisacylphosphonates in reducing alveolar bone loss in the rat model. J Periodontol 2000;71(10):1607-1612.

(38) Grossmann G, Grossmann A, Ohms G, Breuer E, Chen R, Golomb G, et al. Solid-state NMR of bisphosphonates adsorbed on hydroxy apatite. Magn Reson Chem 2000;38(1):11-16.

(39) Cohen H, Alferiev IS, Mönkkönen J, Seibel MJ, Pinto T, Ezra A, et al. Synthesis and preclinical pharmacology of 2-(2-aminopyrimidinio) ethylidene-1,1-bisphosphonic acid betaine (ISA-13-1)-a novel bisphosphonate. Pharm Res 1999;16(9):1399-1406.

(40) Patlas N, Golomb G, Yaffe P, Pinto T, Breuer E, Ornoy A. Transplacental effects of bisphosphonates on fetal skeletal ossification and mineralization in rats. Teratology 1999;60(2):68-73.

(41) Yaffe A, Binderman I, Breuer E, Pinto T, Golomb G. Disposition of alendronate following local delivery in a rat jaw. J Periodontol 1999;70(8):893-895.

(42) Chen R, Breuer E. Direct Approach to α-Hydroxyphosphonic and α,ω-Dihydroxyalkane-α,ω-bisphosphonic Acids by the Reduction of (Bis)acylphosphonic Acids. J Org Chem 1998;63(15):5107-5109.

(43) Cohen H, Solomon V, Alferiev IS, Breuer E, Ornoy A, Patlas N, et al. Bisphosphonates and tetracycline: Experimental models for their evaluation in calcium-related disorders. Pharm Res 1998;15(4):606-613.

(44) Klein BY, Ben-Bassat H, Breuer E, Solomon V, Golomb G. Structurally different bisphosphonates exert opposing effects on alkaline phosphatase and mineralization in marrow osteoprogenitors. J Cell Biochem 1998;68(2):186-194.

(45) Il'Yasov AV, Vafina AA, Breuer E, Hägele G. ESR study of some iminoxy free radicals generated from phosphorylated oximes and dioximes. Appl Magn Reson 1998;14(4):489-496.

(46) Ezra A, Hoffman A, Breuer E, Weiss G, Golomb G. Proteins: Carrier-mediated absorption of bisphosphonate prodrugs. Proc Control Release Soc 1998(25):473-474.

(47) Kehler J, Breuer E. 3-Chloro-3-(dimethoxyphosphoryl)isobenzofuran-1(3H)-one - A new reagent for the rapid, convenient phthaloylation of amines and amino acids in high yields. Synthesis 1998(10):1419-1420.

(48) Mathew M, Fowler BO, Breuer E, Golomb G, Alferiev IS, Eidelman N. Synthesis, Characterization, and Crystal Structure of Dicalcium Glutarylbis(phosphonate) Dihydrate: A Covalently Pillared Layer Structure with the Potential for Epitaxial Growth on Hydroxyapatite. Inorg Chem 1998;37(25):6485-6494.

(49) Van Gelder JM, Breuer E, Schlossman A, Ornoy A, Mönkkönen J, Similä J, et al. In vitro and in vivo effects of tetrakisphosphonates on bone resorption, tumor osteolysis, ectopic calcification, and macrophages. J Pharm Sci 1997;86(3):283-289.

(50) Kehler J, Breuer E. Unusual solvent-dependent behaviour of hydroxyiminophosphonamidates in the Beckmann reactions: Choice between rearrangement or fragmentation to metaphosphonamidate species. Chem Commun 1997(18):1751-1752.

(51) Schoth R-, Lork E, Seifert FU, Breuer E, Röschenthaler G-. Preparation of methyl 2-[Bis(trimethylsiloxy)phosphoryl]-3,3,3-trifluoro-2-(trimethylsiloxy)propionate and some derivatives -molecular structure of methyl 2-[bis(trimethylsiloxy)phosphoryl]-3,3,3-trifluoro-2-hydroxypropionate. Chem Ber 1997;130(2):279-281.

(52) Ezra A, Hoffman A, Breuer E, Weiss G, Lipka E, Amidon GL, et al. Peptidyl prodrugs for improved oral absorption. PROC CONTROL RELEASE SOC 1997(24):243-244.

(53) Salomon CJ, Breuer E. Spontaneous Lossen Rearrangement of (Phosphonoformyl)hydroxamates. The Migratory Aptitude of the Phosphonyl Group. J Org Chem 1997;62(12):3858-3861.

(54) Katzhendler J, Ringel I, Karaman R, Zaher H, Breuer E. Acylphosphonate hemiketals - Formation rate and equilibrium. The electron-withdrawing effect of dimethoxyphosphinyl group. J Chem Soc Perkin Trans 2 1997(2):341-349.

(55) Skrtic D, Eidelman N, Golomb G, Breuer E, Eanes ED. In vitro inhibition of membrane-mediated calcification by novel phosphonates. Calcif Tissue Int 1996;58(5):347-354.

(56) Schoth R-, Lork E, Seifert FU, Röschenthaler G-, Cohen H, Golomb G, et al. Routes to F3-Etidronic Acid (1-Hydroxy-2,2,2-Trifluoroethylidene-Bisphosphonic Acid), Molecular Structure of the Tris(trimethylsilyl)ester, Antimineralization, and Antiresorption Effects of the Disodium Salt. Naturwissenschaften 1996;83(12):571-574.

(57) Golomb G, Van Gelder JM, Alferiev IS, Ornoy A, Hoffman A, Schlossman A, et al. Novel bisphosphonates for calcium-related disorders. Phosphorus Sulfur Silicon Relat Elem 1996;109(1-4):221-224.

(58) Il'yasov A, Breuer E, Hagele G, Vafina A, Liorber B. NMR and ESR study of phosphorylated oximes and iminoxy radicals. Phosphorus Sulfur Silicon Relat Elem 1996;109(1-4):437-440.

(59) Ezra A, Breuer E, Amidon G, Hoffman A, Ornoy A, Patlas N, et al. Peptidyl prodrug of bisphosphonates for improved oral absorption. PROC CONTROL RELEASE SOC 1996(23):83-84.

(60) Breuer E, Zaher H, Tashma Z, Gibson D. Acylphosphonamidates and α-hydroxyiminophosphonamidates. Synthesis of N-acylphosphordiamidates by Beckmann rearrangement. Crystal structure of (E)-α-hydroxyiminobenzyl-1-pyrrolidinylphosphinate. Heteroatom Chem 1996;7(6):515-520.

(61) Salomon CJ, Breuer E. Efficient and selective dealkylation of phosphonate dilsopropyl esters using Me3SiBr. Tetrahedron Lett 1995;36(37):6759-6760.

(62) Van Gelder JM, Breuer E, Ornoy A, Schlossman A, Patlas N, Golomb G. Anticalcification and antiresorption effects of bisacylphosphonates. Bone 1995;16(5):511-520.

(63) Mahajna M, Breuer E. 2-Cyanoethyl and p-nitrophenethyl α-hydroxyimino- and α-methoxyimino-phosphonates: Potential precursors of metaphosphate anion. Journal of the Chemical Society, Perkin Transactions 1 1994(13):1847-1849.

(64) Breuer E, Karaman R, Zaher H, Katz E. Synthesis of some acylphosphonate thiosemicarbazones and evaluation of their antiviral activity. Drug Des Discov 1994;11(1):39-46.

(65) Breuer E, Golomb G, Hoffman A, Schlossman A, Van Gelder JM, Saadeh H, et al. In Vitro and In Vivo Inhibition of Hydroxyapatite Formation and Dissolution by Bisacylphosphonates and Bishydroxyiminophosphonates. Phosphorus Sulfur Silicon Relat Elem 1993;76(1-4):167-170.

(66) Mahajna M, Breuer E. Thermal Fragmentation of Trihaloethyl and Hexafluoro-2-propyl (α-Hydroxyiminobenzyl)phosphonates. Solvent Effects and the Trapping of Metaphosphate. J Org Chem 1993;58(27):7822-7826.

(67) Karle JM, Karle IL, Leader H, Breuer E, Newman AH, Gordon RK, et al. Relationship of the crystal structure of γ-N,N-dimethylaminopropyl 2,2-diphenylpropionate hydrochloride to antimuscarinic activity. Journal of Crystallographic and Spectroscopic Research 1992;22(4):485-491.

(68) Breuer E, Zaher H, Tashma Z. Beckmann rearrangement of N-(α-hydroxyiminoalkylphosphonyl)amino acids. A convenient synthetic approach to novel peptide-transition-state analogs. Tetrahedron Lett 1992;33(15):2067-2068.

(69) Breuer E, Mahajna M. Synthesis and reactions of 2,2,2‐trihaloethyl α‐hydroxyiminobenzylphosphonates. The influence of the ester group on the chemistry of phosphonates. Heteroatom Chem 1992;3(3):251-260.

(70) Bentolila A, Katzhendler J, Breuer E. The reaction of benzoylphosphonic acid with thionyl chloride. the formation of benzoylphosphonic dichloride and P, P'- dibenzoylpyrophosphonic dichloride. Phosphorus Sulfur Silicon Relat Elem 1992;70(1-4):109-112.

(71) Golomb G, Schlossman A, Eitan Y, Saadeh H, Van Gelder JM, Breuer E. In vitro and in vivo anticalcification effects of novel bishydroxyiminophosphonates. J Pharm Sci 1992;81(10):1004-1007.

(72) Golomb G, Schlossman A, Saadeh H, Levi M, Van Gelder JM, Breuer E. Bisacylphosphonates Inhibit Hydroxyapatite Formation and Dissolution in Vitro and Dystrophic Calcification in Vivo. Pharm Res 1992;9(1):143-148.

(73) Breuer E, Safadi M, Chorev M, Gibson D. Evaluation of the n-phthaloyl moiety as protecting group in aminoacylphosphonic derivatives. Phosphorus Sulfur Silicon Relat Elem 1991;60(3-4):239-246.

(74) Breuer E, Mahajna M, Quin LD, Quin GS. Photoinduced Phosphorylation by [α-(Hydroxyimino)benzyl]phosphonates through Fragmentation to Monomeric Metaphosphates. J Org Chem 1991;56(15):4791-4793.

(75) Breuer E, Safadi M, Chorev M, Vineze A, Bel P. Synthesis and characterization of amino protected peptides derived from amino-α- hydroxyiminophosphonates. Tetrahedron 1991;47(7):1257-1264.

(76) Safadi M, Chorev M, Breuer E. Aminoacylphosphonates—novel modified amino acid derivatives. Phosphorus Sulfur Silicon Relat Elem 1990;51(1-4):396.

(77) Schlossman A, Gibson D, Breuer E. Rearrangement and fragmentation reactions of α-hydroxyiminophoshinates. On the nature of the metaphosphonate intermediate involved in phosphonylations by α-hydroxyiminophosphinate. Phosphorus Sulfur Silicon Relat Elem 1990;49-50(1-4):81-84.

(78) Breuer E, Schlossman A, Safadi M, Gibson D, Chorev M, Leader H. Stereoselectivity in fragmentation and rearrangement of α-hydroxyimino-phosphinates and -phosphonates. A synthetic approach to acylphosphon- and phosphor-amidates. Crystal structures of methyl (E)-α-hydroxyimino-benzylphenylphosphinate and methyl benzoylphenylphosphonamidate. Journal of the Chemical Society, Perkin Transactions 1 1990(12):3263-3269.

(79) Breuer E, Safadi M, Chorev M, Gibson D. Novel Amino Acid Derivatives. Preparation and Properties of Aminoacylphosphonates and Amino Hydroxyimino Phosphonates. J Org Chem 1990;55(25):6147-6153.

(80) Quin LD, Wu X-, Breuer E, Mahajna M. The mechanism of fragmentation of alkyl α-(oxyimino)benzylphosphonates; use of silica gel as a novel hydroxylic trapping reactant for an intermediate alkyl metaphosphate. Tetrahedron Lett 1990;31(44):6281-6282.

(81) Breuer E, Karaman R, Goldblum A, Gibson D, Leader H, Potter BVL, et al. Erratum: α-Oxyiminophosphonates: Chemical and physical properties. Reactions, theoretical calculations and crystal structures of (E)- And (Z)-dimethyl α-Hydroxyiminobenzylphosphonates (Journal of the Chemical Society, Perkin Transactions 1 (1988) 3047). Journal of the Chemical Society, Perkin Transactions 1 1989(7):1367.

(82) Breuer E, Karaman R, Gibson D, Goldblum A. Structure and reactivity of 2-hydroxyiminobenzyl-2-oxo-4,4,5,5-tetramethyl[1,3,2]dioxaphospholanes. Phosphorus Sulfur Silicon Relat Elem 1989;41(3-4):433-437.

(83) Katzhendler J, Karaman R, Gibson D, Breuer E, Leader H. Fragmentation of methyl hydrogen α-hydroxyiminophosphonates to monomeric methyl metaphosphate: Stereochemistry and mechanism. Journal of the Chemical Society, Perkin Transactions 2 1989(6):589-594.

(84) Karaman R, Goldblum A, Breuer E, Leader H. Acylphosphonic acids and methyl hydrogen acylphosphonates: Physical and chemical properties and theoretical calculations. Journal of the Chemical Society, Perkin Transactions 1 1989(4):765-774.

(85) Gordon RK, Smejkal RM, Breuer E, Chiang PK. Design and synthesis of antimuscarinics based on physical and mechanical attributes. Prog Clin Biol Res 1989;289:465-470.

(86) Gordon RK, Breuer E, Padilla FN, Smejkal RM, Chiang PK. Distance geometry of α-substituted 2,2-diphenylpropionate antimuscarinics. Mol Pharmacol 1989;36(5):766-772.

(87) Breuer E, Karaman R, Goldblum A, Gibson D, Leader H, Potter BVL, et al. α-Oxyiminophosphonates: Chemical and physical properties. Reactions, theoretical calculations, and x-ray crystal structures of (E) and (Z)-dimethyl α-hydroxyiminobenzylphosphonates. Journal of the Chemical Society, Perkin Transactions 1 1988(11):3047-3057.

(88) Breuer E, Karaman R, Gibson D, Leader H, Goldblum A. α-hydroxyiminophosphonic acids. New types of phosphorylating agents through monomeric metaphosphate. Journal of the Chemical Society, Chemical Communications 1988(7):504-506.

(89) Breuer E, Karaman R, Goldblum A, Leader H. Sulphonic acid-induced fragmentation of dialkyl acylphosphonates, formation of alkyl carboxylates and alkyl sulphonates. Journal of the Chemical Society, Perkin Transactions 2 1988(12):2029-2034.

(90) Brown ND, Smejkal RM, Breuer E, Doctor BP, Chiang PK. Desethylaprophen: A metabolite of aprophen with antimuscarinic activities. J Pharm Sci 1988;77(2):145-148.

(91) Breuer E, Karaman R, Leader H, Goldblum A. Phosphorylation of alcohols through the acid-catalysed fragmentation of α-oxyiminophosphonates. Journal of the Chemical Society, Chemical Communications 1987(9):671-672.

(92) Breuer E, Moshe R. Stereoselectivity in the Wittig‐Horner‐Emmons Synthesis of Vinylphosphonates by the Reaction of Acylphosphonates with Acyclic or Heterocyclic Phosphonoacetates. Isr J Chem 1986;27(1):45-47.

(93) Bottin-Strzalko T, Seyden-Penne J, Breuer E, Pouet M-, Simonnin M-. Wittig-Horner reagents: Structural and conformational study of five- and six-membered cyclic phosphonates and their carbanions. Evidence of anomeric effect in anionic species. Journal of the Chemical Society, Perkin Transactions 2 1985(11):1801-1805.

(94) Breuer E, Melumad D, Sarel S. Antiviral compounds. 2. The preparation and activity of some substituted 3-methyl-1-phenyl-5-pyrazolones. Eur J Med Chem 1983;18(6):481-485.

(95) Breuer E, Melumad D, Sarel So, Katz E. Antiviral compounds. 3. The preparation of some diketophosphonates derived from sugars. Eur J Med Chem 1983;18(6):487-488.

(96) Breuer E, Melumad D, Sarel S, Margalith E, Katz E. Antiviral Compounds. 1. Structure-Activity Relationship of Some Antiviral Enediones Derived from Aldehydo Sugars. J Med Chem 1983;26(1):30-34.

(97) Breuer E, Deutsch J, Lazarovici P. A practical synthesis of the aggregation pheromone of Tribolium castaneum and Tribolium confusum. Chem Ind 1982;No. 22:907-908.

(98) Zbaida S, Breuer E. Nitrones. 6. Reactions of Nitrones with Cyclic Phosphonates. Influence of the Phosphonate Ring Size upon the Course of the Reaction. J Org Chem 1982;47(6):1073-1077.

(99) Noam M, Tamir I, Breuer E, Mechoulam R. Conversion of ruscogenin into 1α- and 1β hydroxycholesterol derivatives. Structure elucidation by computer assisted analysis of their lanthanide-induced nmr shifts. Tetrahedron 1981;37(3):597-604.

(100) Zbaida S, Breuer E. Observation of pentacoordinated phosphorus intermediate in the reactions of nitrones with phosphonate anions. Experientia 1979;35(7):851-852.

(101) Golander Y, Breuer E, Sarel S. Syntheses of Some Norcholanylisoquinoline Derivatives. Arch Pharm 1979;312(4):319-324.

(102) Golander Y, Breuer E, Sarel S. Synthesis of some 2′‐(3‐Oxopregn‐4‐en‐20‐yl)oxazolidines and ‐thiazolidines. Arch Pharm 1979;312(3):192-198.

(103) Zbáida S, Breuer E. Nitrones-V1 1 Part IV: E. Breuer and S. Zbaida, J. Org. Chem. 42, 1904 (1977). Reactions of some nitrones with phosphinoxy ylids. Tetrahedron 1978;34(8):1241-1245.

(104) Zbaida S, Breuer E. Effect of ring size in cyclic phosphonates upon their reaction with nitrones. Journal of the Chemical Society, Chemical Communications 1978(1):6-7.

(105) Breuer E, Bannet DM. The preparation of some cyclic phosphonates and their use in olefin synthesis. Tetrahedron 1978;34(7):997-1002.

(106) Breuer E, Zbaida S. Nitrones. 4. Reactions of Δ1-Pyrroline N-Oxides with Phosphonates. Alternative Formation of Aziridines and Enamines. J Org Chem 1977;42(11):1904-1910.

(107) Golander Y, Breuer E, Sarel S. Synthesis of a Steroidal Dicarbamate Related to Meprobamate from 3‐Ketobisnorcholenal. Isr J Chem 1977;16(1):25-27.

(108) Breuer E, Somekh L, Ringel I. N.m.r. spectra of cyclic amines. II—Factors influencing the chemical shifts of α‐protons in aziridines. Magn Reson Chem 1977;9(6):328-332.

(109) Breuer E, Zbaida S, Pesso J, Ronen-Braunstein I. Nitrones-III1 1 Part II: E. Breuer, S. Zbaida, J. Pesso and S. Levi, Tetrahedron Letters 3104 (1975). Reaction of 3,4-dihydroisoquinoline n-oxide with phosphonoylids. Tetrahedron 1977;33(10):1145-1148.

(110) Breuer E, Bannet DM. Stereoselectivity of wittig type olefin synthesis using five-membered cyclic phosphonates. preferential formation of cis olefins. Tetrahedron Lett 1977;18(13):1141-1144.

(111) Breuer E, Zbaida S. The synthesis of shihunine and related compounds from ortho-carboxyphenyl cyclopropyl ketone. Tetrahedron 1975;31(6):499-504.

(112) Breuer E, Zbaida S, Pesso J, Levi S. Nitrones II. Dualistic behaviour in the reaction of phosphonates with nitrones. Alternative formation of aziridines and enamines. Tetrahedron Lett 1975;16(35):3103-3104.

(113) Breuer E, Zbaida S. The Synthesis of Shihunine Via the Cyclopropyl Ketimine + Pyrroline Rearrangement. Synth Commun 1974;4(1):21-24.

(114) Breuer E, Ronen-Braunstein I. Reaction of a nitrone with a phosphono-ylide. A novel approach to aziridines. Journal of the Chemical Society, Chemical Communications 1974(22):949.

(115) Breuer E, Melumad D. Nuclear Magnetic Resonance Spectra of Cyclic Amines. Shielding of αProtons Trans to a Lone Pair and Cis to an N-Methyl Group in Pyrrolidines. J Org Chem 1973;38(8):1601-1602.

(116) Breuer E, Segall E, Stein Y, Sarel S. Ring Opening in the Hydroboration of Vinylcyclopropane Systems. a Cyclopropylcarbinyl-Allylcarbinylborane Rearrangement. J Org Chem 1972;37(14):2242-2245.

(117) Breuer E, Brown HC, Breuer E. Organoboranes. VIII. Structure of the Thermally Isomerized Organoborane from the Reaction of Borane and 1,3-Butadiene in a 1:1 Molar Ratio. Evidence for an Exceptionally Stable Transannular Boron-Hydrogen Bridge. J Am Chem Soc 1969;91(15):4164-4169.

(118) Breuer E, Melumad D. A one-step synthesis of nicotine from cyclopropyl 3-pyridyl ketone. Tetrahedron Lett 1969;10(41):3595-3596.

(119) Breuer E, Melumad D. The reaction of o-quinone methides with dimethyl sulfoxonium methylide. A simple synthesis of coumarans. Tetrahedron Lett 1969;10(23):1875-1877.

(120) Breuer E, Berger T, Sarel S. Rearrangement of an α-halogenoamides to carbamates by alkoxides. Chemical Communications (London) 1968(24):1596-1597.

(121) Breuer E, Sarel S, Taube A, Sharvit J. Structure Determination of Derivatives of α‐Amino‐α, α‐Diphenylacetamide by Mass Spectrometry. Isr J Chem 1968;6(5):777-785.

(122) Breuer E, Stein Y. Reactions of Cyclopropane Derivatives with Nitrogen Compounds, I. The Synthesis of Pyrrolidines by the Leuckart Reaction of Cyclopropyl Ketones. Isr J Chem 1968;6(6):901-908.

(123) Breuer E, Sarel S. Homoallylic rearrangement of cyclopropylcarbinyl borates. A stereospecific synthesis of trans-4-aryl-3-butenols. Tetrahedron 1968;24(21):6339-6349.

(124) Braedel HU, Breuer E. Scintigraphic examinations in kidney injuries. Fortschr Geb Rontgenstr Nuklearmed 1967;107(2):213-223.

(125) Breuer E. The hydrogenolysis of some cyclopropyl ketones and cyclopropyl carbinols with diborane and borontrifluoride. Tetrahedron Lett 1967;8(20):1849-1854.

(126) Breuer E, Stahler O. Hemolytic jaundice in mushroom poisoning. Med Welt 1966;18:1013-1016.

(127) Sarel S, Breuer E, Klug JT, Fattal Y. Rearrangement and Fragmentation of Pentaphenylazetidinone. Isr J Chem 1966;4(5-6):233-237.

(128) Brown HC, Heydkamp WR, Breuer E, Murphy WS. The Reaction of Organoboranes with Chloramine and with Hydroxylamine-O-sulfonic Acid. A Convenient Synthesis of Amines from Olefins via Hydroboration. J Am Chem Soc 1964;86(17):3565-3566.

(129) Sarel S, Klug JT, Breuer E, D'Angeli F. α-haloamide reactions. III. The reaction of α-chloro-α-α-diphenylacetanilide with sodium hydride. Tetrahedron Lett 1964;5(24):1553-1556.

(130) Sarel S, Breuer E, Ertag S, Salamon R. Polar Effects in the Homoallylic Rearrangement of Arylcyclopropylcarbinols. Isr J Chem 1963;1(4):451-459.

(131) Sarel S, Breuer ELI, Menahem JS. A tracer study of the hydrolysis of ethyl ββ-diethoxyacrylate. Journal of the Chemical Society (Resumed) 1963:66-69.

(132) Sarel S, Breuer E. A Novel Conjugative 1,5-Addition Reaction Involving The Vinylcyclopropane System. J Am Chem Soc 1959;81(24):6522-6523.

(133) Bergmann F, Kalmus A, Breuer E. β-Fluorostyrene. J Am Chem Soc 1958;80(17):4540-4543.

(134) Bergmann F, Kalmus A, Breuer E. ω-Fluoroacetophenone. III. Reaction of Fluoroacetyl Chloride with Halobenzenes. On the Mechanism of Side-chain Chlorination by Sulfuryl Chloride. J Am Chem Soc 1957;79(15):4178-4181.