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School of Pharmacy : Deutsch Joseph

Researchers

 Last updated June 2021 - School of Pharmacy

List of Publications

(1) Shafreen RMB, Lakshmi SA, Pandian SK, Park YS, Kim YM, Paśko P, et al. Unraveling the Antioxidant, Binding and Health-Protecting Properties of Phenolic Compounds of Beers with Main Human Serum Proteins: In Vitro and In Silico Approaches. Molecules 2020;25(21).

(2) Hodes A, Rosen H, Deutsch J, Lifschytz T, Einat H, Lichtstein D. Endogenous cardiac steroids in animal models of mania. Bipolar Disord 2016;18(5):451-459.

(3) Bhattacharjee AK, White L, Chang L, Ma K, Harry GJ, Deutsch J, et al. Bilateral common carotid artery ligation transiently changes brain lipid metabolism in rats. Neurochem Res 2012;37(7):1490-1498.

(4) Shaltiel G, Deutsch J, Rapoport SI, Basselin M, Belmaker RH, Agam G. Is phosphoadenosine phosphate phosphatase a target of lithium's therapeutic effect? J Neural Transm 2009;116(11):1543-1549.

(5) Warburg A, Gelman S, Deutsch J. Xanthine in urine stimulates growth of Leishmania promastigotes in vitro [4]. J Med Microbiol 2008;57(1):136-138.

(6) Ma K, Deutsch J, Villacreses NE, Rosenberger TA, Rapoport SI, Shetty HU. Measuring brain uptake and incorporation into brain phosphatidylinositol of plasma myo-[2H6]inositol in unanesthetized rats: An approach to estimate in vivo brain phosphatidylinositol turnover. Neurochem Res 2006;31(6):759-765.

(7) Deutsch J, Ma K, Rapoport SI. An accelerated mass spectrometric method for measuring myo-inositol in phosphatidylinositol in rat brain. Int J Mass Spectrom 2006;249-250:392-395.

(8) Deutsch J, Jang HG, Mansur N, Ilovich O, Shpolansky U, Galili D, et al. 4-(3′α15′β-dihydroxy-5′β-estran- 17′β-yl)furan-2-methyl alcohol: An anti-digoxin agent with a novel mechanism of action. J Med Chem 2006;49(2):600-606.

(9) Maoz D, Lee H-, Deutsch J, Rapoport SI, Bazinet RP. Immediate no-flow ischemia decreases rat heart nonesterified fatty acid and increases acyl-CoA species concentrations. Lipids 2005;40(11):1149-1154.

(10) Katzir I, Shani J, Goshen G, Sela J, Ninary E, Dogonovski AM, et al. Characterization of nerve growth factors (NGFs) from snake venoms by use of a novel, quantitative bioassay utilizing pheochromocytoma (PC12) cells overexpressing human trkA receptors. Toxicon 2003;42(5):481-490.

(11) Deutsch J, Rapoport SI, Rosenberger TA. Valproyl-CoA and esterified valproic acid are not found in brains of rats treated with valproic acid, but the brain concentrations of CoA and acetyl-CoA are altered. Neurochem Res 2003;28(6):861-866.

(12) Deutsch J, Rapoport SI, Rosenberger TA. Coenzyme A and short-chain Acyl-CoA species in control and ischemic rat brain. Neurochem Res 2002;27(12):1577-1582.

(13) Reszko AE, Kasumov T, Comte B, Pierce BA, David F, Bederman IR, et al. Assay of the concentration and 13C-isotopic enrichment of malonyl-coenzyme A by gas chromatography-mass spectrometry. Anal Biochem 2001;298(1):69-75.

(14) Greig NH, De Micheli E, Holloway HW, Yu Q-, Utsuki T, Perry TA, et al. The experimental alzheimer drug phenserine: Preclinical pharmacokinetics and pharmacodynamics. Acta Neurol Scand Suppl 2000;102(176):74-84.

(15) Deutsch J, Kalderon B, Purdon AD, Rapoport SI. Evaluation of brain long-chain acylcarnitines during cerebral ischemia. Lipids 2000;35(6):693-696.

(16) Lichtstein D, Levy T, Deutsch J, Steinitz M, Zigler Jr. JS, Russell P. The effects of digitalis-like compounds on rat lenses. Invest Ophthalmol Vis Sci 1999;40(2):407-413.

(17) Lichtstein D, Steinitz M, Gati I, Samuelov S, Deutsch J, Orly J. Biosynthesis of digitalis-like compounds in rat adrenal cells: Hydroxycholesterol as possible precursor. Life Sci 1998;62(23):2109-2126.

(18) Lichtstein D, Steinitz M, Gati I, Samuelov S, Deutsch J, Orly J. Bufodienolides as Endogenous Na+, K+-ATPase Inhibitors: Biosynthesis in Bovine and Rat Adrenals. Clin Exp Hypertens 1998;20(42130):573-579.

(19) Rabin O, Chang MCJ, Grange E, Bell J, Rapoport SI, Deutsch J, et al. Selective acceleration of arachidonic acid reincorporation into brain membrane phospholipid following transient ischemia in awake gerbil. J Neurochem 1998;70(1):325-334.

(20) Zähringer U, Wagner F, Rietschel ET, Ben-Menachem G, Deutsch J, Rottem S. Primary structure of a new phosphocholine-containing glycoglycerolipid of Mycoplasma fermentans. J Biol Chem 1997;272(42):26262-26270.

(21) Deutsch J, Rapoport SI, Purdon AD. Relation between free fatty acid and acyl-CoA concentrations in rat brain following decapitation. Neurochem Res 1997;22(7):759-765.

(22) Cohen G, Deutsch J, Fineberg J, Levine A. Covalent attachment of DNA oligonucleotides to glass. Nucleic Acids Res 1997;25(4):911-912.

(23) Di-Capua S, Jang HG, Barasch D, Halperin G, Deutsch J. Mass spectral determination of the configuration of 17β-tetrahydropyranyloxy-19-norandrostan-3β-ol. Int J Mass Spectrom Ion Proces 1997;167-168:79-85.

(24) Rabin O, Deutsch J, Grange E, Pettigrew KD, Chang MCJ, Rapoport SI, et al. Changes in cerebral acyl-CoA concentrations following ischemia- reperfusion in awake gerbils. J Neurochem 1997;68(5):2111-2118.

(25) Rabin O, Grange E, Deutsch J, Chang M, Rapoport SI, Purdon AD. Brain acyl-coa concentration in gerbil ischemia-reperfusion. FASEB J 1996;10(3).

(26) Deutsch J, Rapoport SI, David Purdon A. Isolation and HPLC separation of polyunsaturated species of rat brain acyl-CoA produced during decapitation - Ischemia. Phosphorus Sulfur Silicon Relat Elem 1996;109(1-4):389-392.

(27) Deutsch J, Salman M, Rottem S. An Unusual Polar Lipid from the Cell Membrane of Mycoplasma fermentans. Eur J Biochem 1995;227(3):897-902.

(28) Grange E, Deutsch J, Smith QR, Chang M, Rapoport SI, Purdon AD. Specific Activity of Brain Palmitoyl‐CoA Pool Provides Rates of Incorporation of Palmitate in Brain Phospholipids in Awake Rats. J Neurochem 1995;65(5):2290-2298.

(29) Deutsch J, Grange E, Rapoport SI, Purdon AD. Isolation and quantitation of long-chain acyl-coenzyme A esters in brain tissue by solid-phase extraction. Anal Biochem 1994;220(2):321-323.

(30) Touitou E, Deutsch J, Matar S. Iodine-polyurethane matrices: antimicrobial activity vs method of preparation. Int J Pharm 1994;103(2):199-202.

(31) Gorinstein S, Gorinstein S, Zemser M, Weisz M, Halevy S, Deutsch J, et al. Fluorometric Analysis of Phenolics in Persimmons. Biosci Biotechnol Biochem 1994;58(6):1087-1092.

(32) Genka S, Deutsch J, Shetty UH, Stahle PL, John V, Lieberburg IM, et al. Development of lipophilic anticancer agents for the treatment of brain tumors by the esterification of water-soluble chlorambucil. Clin Exp Metast 1993;11(2):131-140.

(33) LICHTSTEIN D, GATI I, SAMUELOV S, BERSON D, ROZENMAN Y, LANDAU L, et al. Identification of digitalis‐like compounds in human cataractous lenses. Eur J Biochem 1993;216(1):261-268.

(34) Deutsch J, Hegedus L, Greig NH, Rapoport SI, Soncrant TT. Electron-impact and chemical ionization detection of nicotine and cotinine by gas chromatography-mass spectrometry in rat plasma and brain. J Chromatogr B Biomed Sci Appl 1992;579(1):93-98.

(35) Gorinstein S, Moshe R, Deutsch J, Wolfed FH, Tilis K, Stiller A, et al. Determination of basic components in white wines by HPLC, FT-IR spectroscopy, and electrophoretic techniques. J Food Compos Anal 1992;5(3):236-245.

(36) Lichtstein D, Samuelov S, Gati I, Felix AM, Gabriel TF, Deutsch J. Identification of 11,13-dihydroxy-14-octadecaenoic acid as a circulating Na+/K+-ATPase inhibitor. J Endocrinol 1991;128(1):71-78.

(37) Deutsch J, Soncrant TT, Greig NH, Rapoport SI. Electron-impact ionization detection of scopolamine by gas chromatography-mass spectrometry in rat plasma and brain. J Chromatogr B Biomed Sci Appl 1990;528(C):325-331.

(38) Genka S, Deutsch J, Stahle PL, Shetty UH, John V, Robinson C, et al. Brain and plasma pharmacokinetics and anticancer activities of cyclophosphamide and phosphoramide mustard in the rat. Cancer Chemother Pharmacol 1990;27(1):1-7.

(39) Deutsch J, Vatsis KP, Leutz JC, Coon MJ, Gelboin HV. Studies on covalent binding of (-)trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene metabolites to cytochromes p-450 LM2 and LM4 and NADPH-cytochrome p-450 reductase. Xenobiotica 1989;19(12):1421-1435.

(40) Katzhendler J, Cohen S, Rahamim E, Weisz M, Ringel I, Deutsch J. The effect of spacer, linkage and solid support on the synthesis of oligonucleotides. Tetrahedron 1989;45(9):2777-2792.

(41) Deutsch J, Rachmilewitz D. Investigation of field desorption mass spectral behaviour of prostaglandins for their determination in biological fluids. Biol Mass Spectrom 1988;16(1-12):427-430.

(42) Oppenheim A, Cohen S, Goldfarb A, Katzhendler J, Deutsch J, Rachmilewitz EA. Detection of specific bglobin mutations in kurdish jews with βthalassmia. Hemoglobin 1988;12(1):31-38.

(43) Tashma Z, Deutsch J, Cohen S, Weisz M, Katzhendler J, Ringel I. An improved method for the preparation of methyl dichlorophosphite. A key reagent in the phosphite method of oligonucleotide synthesis. Nucleosides Nucleotides 1987;6(3):589-595.

(44) Katzhendler J, Cohen S, Weisz M, Ringel I, Camerini-Oterio RD, Deutsch J. Spacer effect on the synthesis of oligodeoxynucleotides by the phosphite method. Reactive Polymers, Ion Exchangers, Sorbents 1987;6(2-3):175-187.

(45) Lichtstein D, Samuelov S, Deutsch J, Xu H, Lutz RA, Chernick SS, et al. The ouabain receptor in animal tissues and its endogenous ligand. Klin Wochenschr 1987;65(SUPPL. 8):40-48.

(46) Deutsch J, Cohen S, Weisz M, Katzhendler J. A simple and stable silica gel support for the oligodeoxyribonucleotide synthesis. Nucleosides Nucleotides 1986;5(3):325-330.

(47) Lichtstein D, Kachalsky S, Deutsch J. Identification of a ouabain-like compound in toad skin and plasma as a bufodienolide derivative. Life Sci 1986;38(14):1261-1270.

(48) Shimoni Y, Gotsman M, Epstein M, Kachalsky S, Deutsch J, Lichtstein D. Further characterisation of the inotropic effect of a bufodienolide glycoside - an endogenous ouabain like compound. Cardiovasc Res 1986;20(3):229-239.

(49) Lichstein D, Minc D, Bourrit A, Deutsch J, Karlish SJD, Belmaker H, et al. Evidence for the presence of 'Ouabain like' compound in human cerebrospinal fluid. Brain Res 1985;325(1-2):13-19.

(50) Lichtstein D, Minc D, Shimoni Y, Deutsch J, Mekler J, Ben-Ishay D. Demonstration of a ouabainlike plasma compound in hypertension prone and hypertension resistant rats. Hypertension 1985;7(5):729-733.

(51) Shimoni Y, Gotsman M, Deutsch J, Kachalsky S, Lichtstein D. Endogenous ouabain-like compound increases heart muscle contractility. Nature 1984;307(5949):369-371.

(52) GORINSTEIN S, GOLDBLUM A, KITOV S, DEUTSCH J. Fermentation and Post‐Fermentation Changes in Israeli Wines. J Food Sci 1984;49(1):251-256.

(53) Deutsch J, Gelboin HV. Benzo[a]pyrene glucuronide and sulfate conjugate characterization by field desorption mass spectrometry. Biomed Mass Spectrom 1982;9(3):99-102.

(54) Breuer E, Deutsch J, Lazarovici P. A practical synthesis of the aggregation pheromone of Tribolium castaneum and Tribolium confusum. Chem Ind 1982;No. 22:907-908.

(55) Bergmann F, Rahat M, Frank A, Deutsch J. Comparison of the mass spectra of 6‐thiotheophyllines and 6‐sulfinytheophyllines. Org Mass Spectrosc 1982;17(11):565-568.

(56) Gozukara EM, Belvedere G, Robinson RC, Deutsch J, Coon MJ, Guengerich FP, et al. The effect of epoxide hydratase on benzo[a]pyrene diol epoxide hydrolysis and binding to DNA and mixed-function oxidase proteins. Mol Pharmacol 1981;19(1):153-161.

(57) DEUTSCH J, GILON C, CHOREV M. FIELD DESORPTION MASS SPECTROMETRY: II. Potassium Cationization Field Desorption Mass Spectrometry of Some Penta‐ and Hexapeptides Derived from Substance P. Int J Pept Protein Res 1981;18(2):203-207.

(58) Deutsch J. Field desorption mass spectral fragmentation of monosaccharide isomers. Org Mass Spectrosc 1980;15(5):240-243.

(59) Deutsch J, Vatsis KP, Coon MJ, Leutz JC, Gelboin HV. Catalytic activity and stereoselectivity of purified forms of rabbit liver microsomal cytochrome P-450 in the oxygenation of the (-) and (+) enantiomers of trans-7,8-dihydroxy-7,8-dihydrobenzo[α]pyrene. Mol Pharmacol 1979;16(3):1011-1018.

(60) Deutsch J, Chriki M. Mass spectral hydrogen rearrangements of 1,1′‐bicycloalkyldiols under electron impact. Org Mass Spectrosc 1979;14(9):482-484.

(61) Deutsch J, Leutz JC, Coon MJ. Highly purified cytochrome P-450 LM's are bound to different extents during the metabolism of (-)trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene. PROC AM ASSOC CANCER RES 1978;Vol. 19.

(62) Deutsch J, Leutz JC, Yang SK, Gelboin HV, Chiang YL, Vatsis KP, et al. Regio- and stereoselectivity of various forms of purified cytochrome P-450 in the metabolism of benzo[a]pyrene and (-)trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene as shown by product formation and binding to DNA. Proc Natl Acad Sci U S A 1978;75(7):3123-3127.

(63) Deutsch J, Leutz J, Coon M, Gelboin H. Different catalytic activities of two highly purified cytochrome P-450(LM)S in the metabolism and DNA binding of benzo[a]pyrene and (-) TRANS-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene. PROC AM ASSOC CANCER RES 1977;VOL.18.

(64) Deutsch J, Razin A, Sedat J. Analysis of 5-methylcytosine in DNA. I. Mass spectrometry. Anal Biochem 1976;72(1-2):586-592.

(65) Tedeschi E, Kamionsky J, Zeider D, Packler S, Sarel S, Usieli V, et al. Isolation, Characterization, and Synthesis of trans-Pilosine Stereoisomers Occurring in Nature. Circular Dichroism and Mass Spectral Studies. J Org Chem 1974;39(13):1864-1870.

(66) Victor R, Deutsch J, Sarel S. Trends in electron-impact fragmentation of substituted styrenebis(tricarbonyliron) complexes induced by the metal and substitution. J Organomet Chem 1974;71(1):65-76.

(67) Karpati A, Rave A, Deutsch J, Mandelbaum A. Stereospecificity of “Retro-Diels-Alder” Fragmentation under Electron Impact. J Am Chem Soc 1973;95(13):4244-4248.

(68) Lesman T, Deutsch J. Stereospecific hydrogen migration in retro‐diels‐alder fragmentation of some polycyclic imides. Org Mass Spectrosc 1973;7(12):1321-1327.

(69) Tashma Z, Katzhenler J, Deutsch J. Single and double hydrogen rearrangements in the mass spectra of O‐ethyl, S‐alkyl methanephosphonothioates. Org Mass Spectrosc 1973;7(8):955-961.

(70) Deutsch J, Sklarz B. Mass Spectra of Amine Picrates. Isr J Chem 1972;10(1):51-54.

(71) Deutsch J, Mandelbaum A. Studies in mass spectrometry. Part XIV. The effect of conformation on the electron impact-induced fragmentation of adducts of p-benzoquinone and 1,1′-bicycloalkenyls. Journal of the Chemical Society B: Physical Organic 1971:886-889.

(72) Deutsch J, Mandelbaum A. Studies in mass spectrometry—XV: Retro‐diels‐alder fragmentation and double hydrogen migration in some polycyclic diketones. Org Mass Spectrosc 1971;5(1):53-59.

(73) Deutsch J, Neiman Z, Bergmann F. Studies on the mass spectra of 6‐methylthiopurine and its C‐and N‐methyl derivatives. Org Mass Spectrosc 1971;5(3):279-287.

(74) Neiman Z, Bergmann F, Lichtenberg D, Deutsch J. Methylation reactions of 6-methylthio-8-phenylpurines. Journal of the Chemical Society C: Organic Chemistry 1971:1822-1829.

(75) Deutsch J, Mandelbaum A. Studies in Mass Spectrometry. XIII.1 Stereospecific Electron Impact Induced Fragmentation Processes in Some Tricyclic Diesters. J Am Chem Soc 1970;92(14):4288-4291.

(76) Deutsch J, Neiman Z, Bergmann F. Mass‐spectrometric studies on alkylated 6‐thiopurines. Org Mass Spectrosc 1970;3(9):1219-1221.

(77) Deutsch J, Mandelbaum A. The synthesis of 2,2-d2-cyclohexanone and 2,2-d2-cyclopentanone. Tetrahedron Lett 1969;10(17):1351-1352.

(78) Deutsch J, Mandelbaum A. Studies in Mass Spectrometry. Double Hydrogen Migration in Adducts of p-Benzoquinone with Bi-1-cycloalken-1-yls under Electron Impact. J Am Chem Soc 1969;91(17):4809-4813.