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School of Pharmacy : Deutsch Joseph


 Last updated Septmber 2023 - School of Pharmacy

List of Publications


Kim YM, Lubinska-Szczygeł M, Park YS, Deutsch J, Ezra A, Luksrikul P, et al. Characterization of Bioactivity of Selective Molecules in Fruit Wines by FTIR and NMR Spectroscopies, Fluorescence and Docking Calculations. Molecules [Internet]. 2023;28(16). Available from:


Sampath V, Horesh N, Sasi B, Zannadeh H, Pogodin I, Singh SV, et al. Synthesis and Biological Evaluation of Novel Bufalin Derivatives. International Journal of Molecular Sciences [Internet]. 2022;23(7). Available from:


Shafreen RMB, Lakshmi SA, Pandian SK, Kim YM, Deutsch J, Katrich E, et al. In vitro and in silico interaction studies with red wine polyphenols against different proteins from human serum†. Molecules [Internet]. 2021;26(21). Available from:


Shafreen RMB, Lakshmi SA, Pandian SK, Park YS, Kim YM, Paśko P, et al. Unraveling the Antioxidant, Binding and Health-Protecting Properties of Phenolic Compounds of Beers with Main Human Serum Proteins: In Vitro and In Silico Approaches. Molecules (Basel, Switzerland) [Internet]. 2020;25(21). Available from:


Hodes A, Rosen H, Deutsch J, Lifschytz T, Einat H, Lichtstein D. Endogenous cardiac steroids in animal models of mania. Bipolar Disorders [Internet]. 2016;18(5):451–9. Available from:


Bhattacharjee AK, White L, Chang L, Ma K, Harry GJ, Deutsch J, et al. Bilateral common carotid artery ligation transiently changes brain lipid metabolism in rats. Neurochemical Research [Internet]. 2012;37(7):1490–8. Available from:


Shaltiel G, Deutsch J, Rapoport SI, Basselin M, Belmaker RH, Agam G. Is phosphoadenosine phosphate phosphatase a target of lithium’s therapeutic effect? Journal of Neural Transmission [Internet]. 2009;116(11):1543–9. Available from:


Warburg A, Gelman S, Deutsch J. Xanthine in urine stimulates growth of Leishmania promastigotes in vitro [4]. Journal of Medical Microbiology [Internet]. 2008;57(1):136–8. Available from:


Ma K, Deutsch J, Villacreses NE, Rosenberger TA, Rapoport SI, Shetty HU. Measuring brain uptake and incorporation into brain phosphatidylinositol of plasma myo-[2H6]inositol in unanesthetized rats: An approach to estimate in vivo brain phosphatidylinositol turnover. Neurochemical Research [Internet]. 2006;31(6):759–65. Available from:


Deutsch J, Ma K, Rapoport SI. An accelerated mass spectrometric method for measuring myo-inositol in phosphatidylinositol in rat brain. International Journal of Mass Spectrometry [Internet]. 2006;249–250:392–5. Available from:


Deutsch J, Jang HG, Mansur N, Ilovich O, Shpolansky U, Galili D, et al. 4-(3′α15′β-dihydroxy-5′β-estran- 17′β-yl)furan-2-methyl alcohol: An anti-digoxin agent with a novel mechanism of action. Journal of Medicinal Chemistry [Internet]. 2006;49(2):600–6. Available from:


Maoz D, Lee HJ, Deutsch J, Rapoport SI, Bazinet RP. Immediate no-flow ischemia decreases rat heart nonesterified fatty acid and increases acyl-CoA species concentrations. Lipids [Internet]. 2005;40(11):1149–54. Available from:


Ilovich O, Deutsch J. A selective synthesis of 4-bromo-2-furancarboxaldehyde and its pinacolborane derivative. Journal of Heterocyclic Chemistry [Internet]. 2005;42(7):1409–11. Available from:


Katzir I, Shani J, Goshen G, Sela J, Ninary E, Dogonovski AM, et al. Characterization of nerve growth factors (NGFs) from snake venoms by use of a novel, quantitative bioassay utilizing pheochromocytoma (PC12) cells overexpressing human trkA receptors. Toxicon [Internet]. 2003;42(5):481–90. Available from:


Deutsch J, Rapoport SI, Rosenberger TA. Valproyl-CoA and esterified valproic acid are not found in brains of rats treated with valproic acid, but the brain concentrations of CoA and acetyl-CoA are altered. Neurochemical Research [Internet]. 2003;28(6):861–6. Available from:


Deutsch J, Rapoport SI, Rosenberger TA. Coenzyme A and short-chain Acyl-CoA species in control and ischemic rat brain. Neurochemical Research [Internet]. 2002;27(12):1577–82. Available from:


Reszko AE, Kasumov T, Comte B, Pierce BA, David F, Bederman IR, et al. Assay of the concentration and 13C-isotopic enrichment of malonyl-coenzyme A by gas chromatography-mass spectrometry. Analytical Biochemistry [Internet]. 2001;298(1):69–75. Available from:


Greig NH, De Micheli E, Holloway HW, Yu QS, Utsuki T, Perry TA, et al. The experimental alzheimer drug phenserine: Preclinical pharmacokinetics and pharmacodynamics. Acta Neurologica Scandinavica, Supplement [Internet]. 2000;102(176):74–84. Available from:


Deutsch J, Kalderon B, Purdon AD, Rapoport SI. Evaluation of brain long-chain acylcarnitines during cerebral ischemia. Lipids [Internet]. 2000;35(6):693–6. Available from:


Lichtstein D, Levy T, Deutsch J, Steinitz M, Zigler Jr. JS, Russell P. The effects of digitalis-like compounds on rat lenses. Investigative Ophthalmology and Visual Science [Internet]. 1999;40(2):407–13. Available from:


Lichtstein D, Steinitz M, Gati I, Samuelov S, Deutsch J, Orly J. Biosynthesis of digitalis-like compounds in rat adrenal cells: Hydroxycholesterol as possible precursor. Life Sciences [Internet]. 1998;62(23):2109–26. Available from:


Rabin O, Chang MCJ, Grange E, Bell J, Rapoport SI, Deutsch J, et al. Selective acceleration of arachidonic acid reincorporation into brain membrane phospholipid following transient ischemia in awake gerbil. Journal of Neurochemistry [Internet]. 1998;70(1):325–34. Available from:


Lichtstein D, Steinitz M, Gati I, Samuelov S, Deutsch J, Orly J. Bufodienolides as Endogenous Na+, K+-ATPase Inhibitors: Biosynthesis in Bovine and Rat Adrenals. Clinical and Experimental Hypertension [Internet]. 1998;20(42130):573–9. Available from:


Zähringer U, Wagner F, Rietschel ETh, Ben-Menachem G, Deutsch J, Rottem S. Primary structure of a new phosphocholine-containing glycoglycerolipid of Mycoplasma fermentans. Journal of Biological Chemistry [Internet]. 1997;272(42):26262–70. Available from:


Cohen G, Deutsch J, Fineberg J, Levine A. Covalent attachment of DNA oligonucleotides to glass. Nucleic Acids Research [Internet]. 1997;25(4):911–2. Available from:


Deutsch J, Rapoport SI, Purdon AD. Relation between free fatty acid and acyl-CoA concentrations in rat brain following decapitation. Neurochemical Research [Internet]. 1997;22(7):759–65. Available from:


Di-Capua S, Jang HG, Barasch D, Halperin G, Deutsch J. Mass spectral determination of the configuration of 17β-tetrahydropyranyloxy-19-norandrostan-3β-ol. International Journal of Mass Spectrometry and Ion Processes [Internet]. 1997;167–168:79–85. Available from:


Rabin O, Deutsch J, Grange E, Pettigrew KD, Chang MCJ, Rapoport SI, et al. Changes in cerebral acyl-CoA concentrations following ischemia- reperfusion in awake gerbils. Journal of Neurochemistry [Internet]. 1997;68(5):2111–8. Available from:


Rabin O, Grange E, Deutsch J, Chang M, Rapoport SI, Purdon AD. Brain acyl-coa concentration in gerbil ischemia-reperfusion. FASEB Journal [Internet]. 1996;10(3):A673. Available from:


Deutsch J, Rapoport SI, David Purdon A. Isolation and HPLC separation of polyunsaturated species of rat brain acyl-CoA produced during decapitation - Ischemia. Phosphorus, Sulfur and Silicon and Related Elements [Internet]. 1996;109(1–4):389–92. Available from:


Deutsch J, Salman M, Rottem S. An Unusual Polar Lipid from the Cell Membrane of Mycoplasma fermentans. European Journal of Biochemistry [Internet]. 1995;227(3):897–902. Available from:


Grange E, Deutsch J, Smith QR, Chang M, Rapoport SI, Purdon AD. Specific Activity of Brain Palmitoyl‐CoA Pool Provides Rates of Incorporation of Palmitate in Brain Phospholipids in Awake Rats. Journal of Neurochemistry [Internet]. 1995;65(5):2290–8. Available from:


Deutsch J, Grange E, Rapoport SI, Purdon AD. Isolation and quantitation of long-chain acyl-coenzyme A esters in brain tissue by solid-phase extraction. Analytical Biochemistry [Internet]. 1994;220(2):321–3. Available from:


Touitou E, Deutsch J, Matar S. Iodine-polyurethane matrices: antimicrobial activity vs method of preparation. International Journal of Pharmaceutics [Internet]. 1994;103(2):199–202. Available from:


Gorinstein S, Gorinstein S, Zemser M, Weisz M, Halevy S, Deutsch J, et al. Fluorometric Analysis of Phenolics in Persimmons. Bioscience, Biotechnology, and Biochemistry [Internet]. 1994;58(6):1087–92. Available from:


Genka S, Deutsch J, Shetty UH, Stahle PL, John V, Lieberburg IM, et al. Development of lipophilic anticancer agents for the treatment of brain tumors by the esterification of water-soluble chlorambucil. Clinical & Experimental Metastasis [Internet]. 1993;11(2):131–40. Available from:


LICHTSTEIN D, GATI I, SAMUELOV S, BERSON D, ROZENMAN Y, LANDAU L, et al. Identification of digitalis‐like compounds in human cataractous lenses. European Journal of Biochemistry [Internet]. 1993;216(1):261–8. Available from:


Deutsch J, Hegedus L, Greig NH, Rapoport SI, Soncrant TT. Electron-impact and chemical ionization detection of nicotine and cotinine by gas chromatography-mass spectrometry in rat plasma and brain. Journal of Chromatography B: Biomedical Sciences and Applications [Internet]. 1992;579(1):93–8. Available from:


Gorinstein S, Moshe R, Deutsch J, Wolfed FH, Tilis K, Stiller A, et al. Determination of basic components in white wines by HPLC, FT-IR spectroscopy, and electrophoretic techniques. Journal of Food Composition and Analysis [Internet]. 1992;5(3):236–45. Available from:


Lichtstein D, Samuelov S, Gati I, Felix AM, Gabriel TF, Deutsch J. Identification of 11,13-dihydroxy-14-octadecaenoic acid as a circulating Na+/K+-ATPase inhibitor. Journal of Endocrinology [Internet]. 1991;128(1):71–8. Available from:


Genka S, Deutsch J, Stahle PL, Shetty UH, John V, Robinson C, et al. Brain and plasma pharmacokinetics and anticancer activities of cyclophosphamide and phosphoramide mustard in the rat. Cancer Chemotherapy and Pharmacology [Internet]. 1990;27(1):1–7. Available from:


Deutsch J, Soncrant TT, Greig NH, Rapoport SI. Electron-impact ionization detection of scopolamine by gas chromatography-mass spectrometry in rat plasma and brain. Journal of Chromatography B: Biomedical Sciences and Applications [Internet]. 1990;528(C):325–31. Available from:


Deutsch J, Vatsis KP, Leutz JC, Coon MJ, Gelboin HV. Studies on covalent binding of (-)trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene metabolites to cytochromes p-450 LM2 and LM4 and NADPH-cytochrome p-450 reductase. Xenobiotica [Internet]. 1989;19(12):1421–35. Available from:


Katzhendler J, Cohen S, Rahamim E, Weisz M, Ringel I, Deutsch J. The effect of spacer, linkage and solid support on the synthesis of oligonucleotides. Tetrahedron [Internet]. 1989;45(9):2777–92. Available from:


Oppenheim A, Cohen S, Goldfarb A, Katzhendler J, Deutsch J, Rachmilewitz EA. Detection of specific bglobin mutations in kurdish jews with βthalassmia. Hemoglobin [Internet]. 1988;12(1):31–8. Available from:


Deutsch J, Rachmilewitz D. Investigation of field desorption mass spectral behaviour of prostaglandins for their determination in biological fluids. Biological Mass Spectrometry [Internet]. 1988;16(1–12):427–30. Available from:


Tashma Z, Deutsch J, Cohen S, Weisz M, Katzhendler J, Ringel I. An improved method for the preparation of methyl dichlorophosphite. A key reagent in the phosphite method of oligonucleotide synthesis. Nucleosides and Nucleotides [Internet]. 1987;6(3):589–95. Available from:


Lichtstein D, Samuelov S, Deutsch J, Xu H, Lutz RA, Chernick SS, et al. The ouabain receptor in animal tissues and its endogenous ligand. Klinische Wochenschrift [Internet]. 1987;65(SUPPL. 8):40–8. Available from:


Katzhendler J, Cohen S, Weisz M, Ringel I, Camerini-Oterio RD, Deutsch J. Spacer effect on the synthesis of oligodeoxynucleotides by the phosphite method. Reactive Polymers, Ion Exchangers, Sorbents [Internet]. 1987;6(2–3):175–87. Available from:


Deutsch J, Cohen S, Weisz M, Katzhendler J. A simple and stable silica gel support for the oligodeoxyribonucleotide synthesis. Nucleosides and Nucleotides [Internet]. 1986;5(3):325–30. Available from:


Lichtstein D, Kachalsky S, Deutsch J. Identification of a ouabain-like compound in toad skin and plasma as a bufodienolide derivative. Life Sciences [Internet]. 1986;38(14):1261–70. Available from:


Shimoni Y, Gotsman M, Epstein M, Kachalsky S, Deutsch J, Lichtstein D. Further characterisation of the inotropic effect of a bufodienolide glycoside - an endogenous ouabain like compound. Cardiovascular Research [Internet]. 1986;20(3):229–39. Available from:


Lichstein D, Minc D, Bourrit A, Deutsch J, Karlish SJD, Belmaker H, et al. Evidence for the presence of “Ouabain like” compound in human cerebrospinal fluid. Brain Research [Internet]. 1985;325(1–2):13–9. Available from:


Lichtstein D, Minc D, Shimoni Y, Deutsch J, Mekler J, Ben-Ishay D. Demonstration of a ouabainlike plasma compound in hypertension prone and hypertension resistant rats. Hypertension [Internet]. 1985;7(5):729–33. Available from:


Shimoni Y, Gotsman M, Deutsch J, Kachalsky S, Lichtstein D. Endogenous ouabain-like compound increases heart muscle contractility. Nature [Internet]. 1984;307(5949):369–71. Available from:


GORINSTEIN S, GOLDBLUM A, KITOV S, DEUTSCH J. Fermentation and Post‐Fermentation Changes in Israeli Wines. Journal of Food Science [Internet]. 1984;49(1):251–6. Available from:


Bergmann F, Rahat M, Frank A, Deutsch J. Comparison of the mass spectra of 6‐thiotheophyllines and 6‐sulfinytheophyllines. Organic Mass Spectrometry [Internet]. 1982;17(11):565–8. Available from:


Breuer E, Deutsch J, Lazarovici P. A practical synthesis of the aggregation pheromone of Tribolium castaneum and Tribolium confusum. Chemistry and Industry (London) [Internet]. 1982;No. 22:907–8. Available from:


Deutsch J, Gelboin HV. Benzo[a]pyrene glucuronide and sulfate conjugate characterization by field desorption mass spectrometry. Biological Mass Spectrometry [Internet]. 1982;9(3):99–102. Available from:


Gozukara EM, Belvedere G, Robinson RC, Deutsch J, Coon MJ, Guengerich FP, et al. The effect of epoxide hydratase on benzo[a]pyrene diol epoxide hydrolysis and binding to DNA and mixed-function oxidase proteins. Molecular Pharmacology [Internet]. 1981;19(1):153–61. Available from:


DEUTSCH J, GILON C, CHOREV M. FIELD DESORPTION MASS SPECTROMETRY: II. Potassium Cationization Field Desorption Mass Spectrometry of Some Penta‐ and Hexapeptides Derived from Substance P. International Journal of Peptide and Protein Research [Internet]. 1981;18(2):203–7. Available from:


Deutsch J. Field desorption mass spectral fragmentation of monosaccharide isomers. Organic Mass Spectrometry [Internet]. 1980;15(5):240–3. Available from:


Deutsch J, Vatsis KP, Coon MJ, Leutz JC, Gelboin HV. Catalytic activity and stereoselectivity of purified forms of rabbit liver microsomal cytochrome P-450 in the oxygenation of the (-) and (+) enantiomers of trans-7,8-dihydroxy-7,8-dihydrobenzo[α]pyrene. Molecular Pharmacology [Internet]. 1979;16(3):1011–8. Available from:


Deutsch J, Chriki M. Mass spectral hydrogen rearrangements of 1,1′‐bicycloalkyldiols under electron impact. Organic Mass Spectrometry [Internet]. 1979;14(9):482–4. Available from:


Deutsch J, Leutz JC, Yang SK, Gelboin HV, Chiang YL, Vatsis KP, et al. Regio- and stereoselectivity of various forms of purified cytochrome P-450 in the metabolism of benzo[a]pyrene and (-)trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene as shown by product formation and binding to DNA. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 1978;75(7):3123–7. Available from:


Deutsch J, Leutz JC, Coon MJ. Highly purified cytochrome P-450 LM’s are bound to different extents during the metabolism of (-)trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene. Proceedings of the American Association for Cancer Research [Internet]. 1978;Vol. 19:No. 307. Available from:


Deutsch J, Leutz J, Coon M, Gelboin H. Different catalytic activities of two highly purified cytochrome P-450(LM)S in the metabolism and DNA binding of benzo[a]pyrene and (-) TRANS-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene. Proceedings of the American Association for Cancer Research [Internet]. 1977;VOL.18:No.835. Available from:


Deutsch J, Razin A, Sedat J. Analysis of 5-methylcytosine in DNA. I. Mass spectrometry. Analytical Biochemistry [Internet]. 1976;72(1–2):586–92. Available from:


Tedeschi E, Kamionsky J, Zeider D, Packler S, Sarel S, Usieli V, et al. Isolation, Characterization, and Synthesis of trans-Pilosine Stereoisomers Occurring in Nature. Circular Dichroism and Mass Spectral Studies. Journal of Organic Chemistry [Internet]. 1974;39(13):1864–70. Available from:


Victor R, Deutsch J, Sarel S. Trends in electron-impact fragmentation of substituted styrenebis(tricarbonyliron) complexes induced by the metal and substitution. Journal of Organometallic Chemistry [Internet]. 1974;71(1):65–76. Available from:


Karpati A, Rave A, Deutsch J, Mandelbaum A. Stereospecificity of “Retro-Diels-Alder” Fragmentation under Electron Impact. Journal of the American Chemical Society [Internet]. 1973;95(13):4244–8. Available from:


Tashma Z, Katzhenler J, Deutsch J. Single and double hydrogen rearrangements in the mass spectra of O‐ethyl, S‐alkyl methanephosphonothioates. Organic Mass Spectrometry [Internet]. 1973;7(8):955–61. Available from:


Lesman T, Deutsch J. Stereospecific hydrogen migration in retro‐diels‐alder fragmentation of some polycyclic imides. Organic Mass Spectrometry [Internet]. 1973;7(12):1321–7. Available from:


Deutsch J, Sklarz B. Mass Spectra of Amine Picrates. Israel Journal of Chemistry [Internet]. 1972;10(1):51–4. Available from:


Deutsch J, Neiman Z, Bergmann F. Studies on the mass spectra of 6‐methylthiopurine and its C‐and N‐methyl derivatives. Organic Mass Spectrometry [Internet]. 1971;5(3):279–87. Available from:


Neiman Z, Bergmann F, Lichtenberg D, Deutsch J. Methylation reactions of 6-methylthio-8-phenylpurines. Journal of the Chemical Society C: Organic Chemistry [Internet]. 1971;1822–9. Available from:


Deutsch J, Mandelbaum A. Studies in mass spectrometry. Part XIV. The effect of conformation on the electron impact-induced fragmentation of adducts of p-benzoquinone and 1,1′-bicycloalkenyls. Journal of the Chemical Society B: Physical Organic [Internet]. 1971;886–9. Available from:


Deutsch J, Mandelbaum A. Studies in mass spectrometry—XV: Retro‐diels‐alder fragmentation and double hydrogen migration in some polycyclic diketones. Organic Mass Spectrometry [Internet]. 1971;5(1):53–9. Available from:


Deutsch J, Mandelbaum A. Studies in Mass Spectrometry. XIII.1 Stereospecific Electron Impact Induced Fragmentation Processes in Some Tricyclic Diesters. Journal of the American Chemical Society [Internet]. 1970;92(14):4288–91. Available from:


Deutsch J, Neiman Z, Bergmann F. Mass‐spectrometric studies on alkylated 6‐thiopurines. Organic Mass Spectrometry [Internet]. 1970;3(9):1219–21. Available from:


Deutsch J, Mandelbaum A. The synthesis of 2,2-d2-cyclohexanone and 2,2-d2-cyclopentanone. Tetrahedron Letters [Internet]. 1969;10(17):1351–2. Available from:


Deutsch J, Mandelbaum A. Studies in Mass Spectrometry. Double Hydrogen Migration in Adducts of p-Benzoquinone with Bi-1-cycloalken-1-yls under Electron Impact. Journal of the American Chemical Society [Internet]. 1969;91(17):4809–13. Available from: