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Hadassah Medical Center - Gene Therapy: Abramovitch Rinat


Last updated February 2023 - Gene Therapy

List of Publications

(1) Dahan T, Nassar S, Yajuk O, Steinberg E, Benny O, Abudi N, et al. Chronic Intermittent Hypoxia during Sleep Causes Browning of Interscapular Adipose Tissue Accompanied by Local Insulin Resistance in Mice. Int J Mol Sci 2022;23(24).

(2) Hinden L, Ahmad M, Hamad S, Nemirovski A, Szanda G, Glasmacher S, et al. Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function. Nat Commun 2022;13(1).

(3) Abudi N, Duev O, Asraf T, Blank S, Matot I, Abramovitch R. Premature Macrophage Activation by Stored Red Blood Cell Transfusion Halts Liver Regeneration Post-Partial Hepatectomy in Rats. Cells 2022;11(21).

(4) Shriki A, Lanton T, Sonnenblick A, Levkovitch-Siany O, Eidelshtein D, Abramovitch R, et al. Multiple roles of il6 in hepatic injury, steatosis, and senescence aggregate to suppress tumorigenesis. Cancer Res 2021;81(18):4766-4777.

(5) Grunewald M, Kumar S, Sharife H, Volinsky E, Gileles-Hillel A, Licht T, et al. Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span. Science 2021;373(6554).

(6) Ginosar Y, Bromberg Z, Nachmanson N, Ariel I, Skarzinski G, Hagai L, et al. Chronic hypoxia in pregnant mice impairs the placental and fetal vascular response to acute hypercapnia in BOLD-MRI hemodynamic response imaging. Placenta 2021;110:29-38.

(7) Shapiro J, Ginosar Y, Gielchinsky Y, Elchalal U, Bromberg Z, Corchia-Nachmanson N, et al. BOLD-MRI demonstrates acute placental and fetal organ hypoperfusion with fetal brain sparing in response to phenylephrine but not ephedrine. Placenta 2020;90:52-57.

(8) Klein S, Abraham M, Bulvik B, Dery E, Weiss ID, Barashi N, et al. CXCR4 promotes neuroblastoma growth and therapeutic resistance through miR-15a/ 16-1–mediated ERK and BCL2/Cyclin D1 pathways. Cancer Res 2018;78(6):1471-1483.

(9) Ginosar Y, Gielchinsky Y, Nachmansson N, Hagai L, Shapiro J, Elchalal U, et al. BOLD-MRI demonstrates acute placental and fetal organ hypoperfusion with fetal brain sparing during hypercapnia. Placenta 2018;63:53-60.

(10) Lanton T, Shriki A, Nechemia-Arbely Y, Abramovitch R, Levkovitch O, Adar R, et al. Interleukin 6–dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis. Hepatology 2017;65(5):1600-1611.

(11) Fähling M, Mathia S, Scheidl J, Abramovitch R, Milman Z, Paliege A, et al. Cyclosporin a induces renal episodic hypoxia. Acta Physiol 2017;219(3):625-639.

(12) Matot I, Nachmansson N, Duev O, Schulz S, Schroeder-Stein K, Frede S, et al. Impaired liver regeneration after hepatectomy and bleeding is associated with a shift from hepatocyte proliferation to hypertrophy. FASEB J 2017;31(12):5283-5295.

(13) Ginosar Y, Nachmanson NC, Shapiro J, Weissman C, Abramovitch R. Inhaled carbon dioxide causes dose-dependent paradoxical bradypnea in animals anesthetized with pentobarbital, but not with isoflurane or ketamine. Respir Physiol Neurobiol 2015;217:1-7.

(14) Hijazi N, Fanne RA, Abramovitch R, Yarovoi S, Higazi M, Abdeen S, et al. Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice. Blood 2015;125(16):2558-2567.

(15) Zeira E, Abramovitch R, Meir K, Ram SE, Gil Y, Bulvik B, et al. The knockdown of H19lncRNA reveals its regulatory role in pluripotency and tumorigenesis of human embryonic carcinoma cells. Oncotarget 2015;6(33):34691-34703.

(16) Tempel-Brami C, Schiffenbauer YS, Nyska A, Ezov N, Spector I, Abramovitch R, et al. Practical Applications of in Vivo and ex Vivo MRI in Toxicologic Pathology Using a Novel High-performance Compact MRI System. Toxicol Pathol 2015;43(5):633-650.

(17) Laufer H, Mazuz A, Nachmansson N, Fellig Y, Corn BW, Bokstein F, et al. Monitoring brain tumor vascular heamodynamic following anti-angiogenic therapy with advanced magnetic resonance imaging in mice. PLoS ONE 2014;9(12).

(18) Komar-Stossel C, Gross E, Dery E, Corchia N, Meir K, Fried I, et al. TL-118 and gemcitabine drug combination display therapeutic efficacy in a mycn amplified orthotopic neuroblastoma murine model - Evaluation by MRI. PLoS ONE 2014;9(3).

(19) Ella E, Heim D, Stoyanov E, Harari-Steinfeld R, Steinfeld I, Pappo O, et al. Specific genomic and transcriptomic aberrations in tumors induced by partial hepatectomy of a chronically inflamed murine liver. Oncotarget 2014;5(21):10318-10331.

(20) Edrei Y, Freiman M, Sklair-Levy M, Tsarfaty G, Gross E, Joskowicz L, et al. Quantitative functional MRI biomarkers improved early detection of colorectal liver metastases. J Magn Reson Imaging 2014;39(5):1246-1253.

(21) Milman Z, Axelrod JH, Heyman SN, Nachmansson N, Abramovitch R. Assessment with unenhanced MRI techniques of renal morphology and hemodynamic changes during acute kidney injury and chronic kidney disease in mice. Am J Nephrol 2014;39(3):268-278.

(22) Khvalevsky EZ, Gabai R, Rachmut IH, Horwitz E, Brunschwig Z, Orbach A, et al. Mutant KRAS is a druggable target for pancreatic cancer. Proc Natl Acad Sci U S A 2013;110(51):20723-20728.

(23) Barashi N, Weiss ID, Wald O, Wald H, Beider K, Abraham M, et al. Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice. Hepatology 2013;58(3):1021-1030.

(24) Artzi M, Aizenstein O, Abramovitch R, Bashat DB. MRI multiparametric hemodynamic characterization of the normal brain. Neuroscience 2013;240:269-276.

(25) Milman Z, Heyman SN, Corchia N, Edrei Y, Axelrod JH, Rosenberger C, et al. Hemodynamic response magnetic resonance imaging: Application for renal hemodynamic characterization. Nephrol Dial Transplant 2013;28(5):1150-1156.

(26) Matot I, Katz M, Pappo O, Zelig O, Corchia N, Yedgar S, et al. Resuscitation with aged blood exacerbates liver injury in a hemorrhagic rat model. Crit Care Med 2013;41(3):842-849.

(27) Ben Bashat D, Artzi M, Ben Ami H, Aizenstein O, Blumenthal DT, Bokstein F, et al. Hemodynamic Response Imaging: A Potential Tool for the Assessment of Angiogenesis in Brain Tumors. PLoS ONE 2012;7(11).

(28) Edrei Y, Gross E, Corchia N, Abramovitch R. Improved efficacy of a novel anti-angiogenic drug combination (TL-118) against colorectal-cancer liver metastases; MRI monitoring in mice. Br J Cancer 2012;107(4):658-666.

(29) Sela Y, Freiman M, Dery E, Edrei Y, Safadi R, Pappo O, et al. FMRI-based hierarchical SVM model for the classification and grading of liver fibrosis. IEEE Trans Biomed Eng 2011;58(9):2574-2581.

(30) Edrei Y, Gross E, Corchia N, Tsarfaty G, Galun E, Pappo O, et al. Vascular profile characterization of liver tumors by magnetic resonance imaging using hemodynamic response imaging in mice. Neoplasia 2011;13(3):244-253.

(31) Cohen I, Maoz M, Turm H, Grisaru-Granovsky S, Maly B, Uziely B, et al. Etk/Bmx regulates proteinase-activated-receptor1 (PAR1) in breast cancer invasion: Signaling partners, hierarchy and physiological significance. PLoS ONE 2010;5(6).

(32) Gielchinsky Y, Laufer N, Weitman E, Abramovitch R, Granot Z, Bergman Y, et al. Pregnancy restores the regenerative capacity of the aged liver via activation of an mTORC1-controlled hyperplasia/hypertrophy switch. Genes Dev 2010;24(6):543-548.

(33) Barash H, Gross ER, Edrei Y, Ella E, Israel A, Cohen I, et al. Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks. Proc Natl Acad Sci U S A 2010;107(5):2207-2212.

(34) Multi-class SVM model for fMRI-based classification and grading of liver fibrosis. Progress in Biomedical Optics and Imaging - Proceedings of SPIE; 2010.

(35) Zorde-Khvalevsky E, Abramovitch R, Barash H, Spivak-Pohis I, Rivkin L, Rachmilewitz J, et al. Toll-like receptor 3 signaling attenuates liver regeneration. Hepatology 2009;50(1):198-206.

(36) Beider K, Abraham M, Begin M, Wald H, Weiss ID, Wald O, et al. Interaction between CXCR4 and CCL20 pathways regulates tumor growth. PLoS ONE 2009;4(4).

(37) Freiman M, Edrei Y, Sela Y, Shmidmayer Y, Gross E, Joskowicz L, et al. Classification of suspected liver metastases using fMRI images: A machine learning approach. Lect Notes Comput Sci 2008;5241 LNCS(PART 1):93-100.

(38) Barash H, Gross E, Edrei Y, Pappo O, Spira G, Vlodavsky I, et al. Functional magnetic resonance imaging monitoring of pathological changes in rodent livers during hyperoxia and hypercapnia. Hepatology 2008;48(4):1232-1241.

(39) Liver metastasis early detection using fMRI based statistical model. 2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI; 2008.

(40) Meyuhas R, Pikarsky E, Tavor E, Klar A, Abramovitch R, Hochman J, et al. A key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1(CYR61) in tumor cells. Mol Cancer Res 2008;6(9):1397-1409.

(41) Ben Moshe T, Kang T-, Kovalenko A, Barash H, Abramovitch R, Galun E, et al. Cell-autonomous and non-cell-autonomous functions of caspase-8. Cytokine Growth Factor Rev 2008;19(3-4):209-217.

(42) Matot I, Einav S, Weiniger CF, Pearl RG, Abramovitch R, Joshi BV, et al. Lung injury after in vivo reperfusion: Outcome at 27 hours after reperfusion. Anesthesiology 2008;109(2):269-278.

(43) Matot I, Cohen K, Pappo O, Barash H, Abramovitch R. Liver response to hemorrhagic shock and subsequent resuscitation: MRI analysis. Shock 2008;29(1):16-24.

(44) Barash H, Gross E, Matot I, Edrei Y, Tsarfaty G, Spira G, et al. Functional MR imaging during hypercapnia and hyperoxia: Noninvasive tool for monitoring changes in liver perfusion and hemodynamics in a rat model. Radiology 2007;243(3):727-735.

(45) Ben Moshe T, Barash H, Kang T-, Kim J-, Kovalenko A, Gross E, et al. Role of caspase-8 in hepatocyte response to infection and injury in mice. Hepatology 2007;45(4):1014-1024.

(46) Gafni Y, Zilberman Y, Ophir Z, Abramovitch R, Jaffe M, Gazit Z, et al. Design of a filamentous polymeric scaffold for in vivo guided angiogenesis. Tissue Eng 2006;12(11):3021-3034.

(47) Grunewald M, Avraham I, Dor Y, Bachar-Lustig E, Itin A, Yung S, et al. VEGF-Induced Adult Neovascularization: Recruitment, Retention, and Role of Accessory Cells (DOI:10.1016/j.cell.2005.10.036). Cell 2006;126(4):811.

(48) Cohen I, Pappo O, Elkin M, San T, Bar-Shavit R, Hazan R, et al. Heparanase promotes growth, angiogenesis and survival of primary breast tumors. Int J Cancer 2006;118(7):1609-1617.

(49) Grunewald M, Avraham I, Dor Y, Bachar-Lustig E, Itin A, Yung S, et al. VEGF-induced adult neovascularization: Recruitment, retention, and role of accessory cells. Cell 2006;124(1):175-189.

(50) Zcharia E, Zilka R, Yaar A, Yacoby-Zeevi O, Zetser A, Metzger S, et al. Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models. FASEB J 2005;19(2):211-221.

(51) Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, et al. NF-κB functions as a tumour promoter in inflammation-associated cancer. Nature 2004;431(7007):461-466.

(52) Darash-Yahana M, Pikarsky E, Abramovitch R, Zeira E, Pal B, Karplus R, et al. Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis. FASEB J 2004;18(11):1240-1242.

(53) Shabat S, Nyska A, Long PH, Goelman G, Abramovitch R, Ezov N, et al. Osteonecrosis in a Chemically Induced Rat Model of Human Hemolytic Disorders Associated with Thrombosis - A New Model for Avascular Necrosis of Bone. Calcif Tissue Int 2004;74(3):220-228.

(54) Abramovitch R, Tavor E, Jacob-Hirsch J, Zeira E, Amariglio N, Pappo O, et al. A Pivotal Role of Cyclic AMP-Responsive Element Binding Protein in Tumor Progression. Cancer Res 2004;64(4):1338-1346.

(55) Abramovitch R, Itzik A, Harel H, Nagler A, Vlodavsky I, Siegal T. Halofuginone inhibits angiogenesis and growth in implanted metastatic rat brain tumor model - An MRI study. Neoplasia 2004;6(5):480-489.

(56) Goldshmidt O, Zcharia E, Abramovitch R, Metzger S, Aingorn H, Friedmann Y, et al. Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis. Proc Natl Acad Sci U S A 2002;99(15):10031-10036.

(57) Dor Y, Djonov V, Abramovitch R, Itin A, Fishman GI, Carmeliet P, et al. Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy. EMBO J 2002;21(8):1939-1947.

(58) Shaharabany M, Abramovitch R, Kushnir T, Tsarfaty G, Ravid-Megido M, Horev J, et al. In vivo molecular imaging of met tyrosine kinase growth factor receptor activity in normal organs and breast tumors. Cancer Res 2001;61(12):4873-4878.

(59) Gross DJ, Reibstein I, Weiss L, Slavin S, Stein I, Neeman M, et al. The antiangiogenic agent linomide inhibits the growth rate of von Hippel-Lindau paraganglioma xenografts to mice. Clin Canc Res 1999;5(11):3669-3675.

(60) Abramovitch R, Dafni H, Smouha E, Benjamin LE, Neeman M. In vivo prediction of vascular susceptibility to vascular endothelial growth factor withdrawal: Magnetic resonance imaging of C6 rat glioma in nude mice. Cancer Res 1999;59(19):5012-5016.

(61) Abramovitch R, Dafni H, Neeman M, Nagler A, Pines M. Inhibition of Neovascularization and Tumor Growth, and Facilitation of Wound Repair, by Halofuginone, an Inhibitor of Collagen Type I Synthesis. Neoplasia 1999;1(4):321-329.

(62) Abramovitch R, Marikovsky M, Meir G, Neeman M. Stimulation of tumour growth by wound-derived growth factors. Br J Cancer 1999;79(9-10):1392-1398.

(63) Carmeliet P, Dor Y, Herbert J-, Fukumura D, Brusselmans K, Dewerchin M, et al. Erratum: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (Nature (1998) 394 (485-490)). Nature 1998;395(6701):525.

(64) Carmeliet P, Dor Y, Herber J-, Fukumura D, Brusselmans K, Dewerchin M, et al. Role of HIF-1α in hypoxiamediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998;394(6692):485-490.

(65) Abramovitch R, Neeman M, Reich R, Stein I, Keshet E, Abraham J, et al. Intercellular communication between vascular smooth muscle and endothelial cells mediated by heparin-binding epidermal growth factor-like growth factor and vascular endothelial growth factor. FEBS Lett 1998;425(3):441-447.

(66) Abramovitch R, Frenkiel D, Neeman M. Analysis of subcutaneous angiogenesis by gradient echo magnetic resonance imaging. Magn Reson Med 1998;39(5):813-824.

(67) Abramovitch R, Marikovsky M, Meir G, Neeman M. Stimulation of tumour angiogenesis by proximal wounds: Spatial and temporal analysis by MRI. Br J Cancer 1998;77(3):440-447.

(68) Schiffenbauer YS, Abramovitch R, Meir G, Nevo N, Holzinger M, Itin A, et al. Loss of ovarian function promotes angiogenesis in human ovarian carcinoma. Proc Natl Acad Sci U S A 1997;94(24):13203-13208.

(69) Neeman M, Abramovitch R, Schiffenbauer YS, Tempel C. Regulation of angiogenesis by hypoxic stress: From solid tumours to the ovarian follicle. Int J Exp Pathol 1997;78(2):57-70.

(70) Abramovitch R, Meir G, Neeman M. Neovascularization Induced Growth of Implanted C6 Glioma Multicellular Spheroids: Magnetic Resonance Microimaging. Cancer Res 1995;55(9):1956-1962.

(71) Schiffenbauer YS, Tempel C, Abramovitch R, Meir G, Neeman M. Cyclocreatine Accumulation Leads to Cellular Swelling in C6 Glioma Multicellular Spheroids: Diffusion and One-Dimensional Chemical Shift Nuclear Magnetic Resonance Microscopy. Cancer Res 1995;55(1):153-158.