Skip to Main Content

HUJI logo Hebrew
The Library Authority    רשות הספריות

Library Research Guides    מדריכים לפי תחומים


Hadassah Medical Center - Gene Therapy: Abramovitch Rinat

researchers

Last updated May 2025- Gene Therapy

List of Publications

1.     Cemal SD, Kazimirsky G, Shadkchan Y, et al. Biocompatible narrow size nanohydrogels for drug delivery. Nanomedicine Nanotechnology, Biol Med. 2025;66. doi:10.1016/j.nano.2025.102824
2.     Michaeli TF, Sabag O, Azria B, et al. Hepatocyte regeneration is driven by embryo-like DNA methylation reprogramming. Proc Natl Acad Sci U S A. 2024;121(16). doi:10.1073/pnas.2314885121
3.     Harazi A, Yakovlev L, Ilouz N, et al. Induced Muscle and Liver Absence of Gne in Postnatal Mice Does Not Result in Structural or Functional Muscle Impairment. J Neuromuscul Dis. 2024;11(5):905-917. doi:10.3233/JND-240056
4.     Yehezkel AS, Abudi N, Nevo Y, et al. AN1284 attenuates steatosis, lipogenesis, and fibrosis in mice with pre-existing non-alcoholic steatohepatitis and directly affects aryl hydrocarbon receptor in a hepatic cell line. Front Endocrinol (Lausanne). 2023;14. doi:10.3389/fendo.2023.1226808
5.     Hinden L, Ahmad M, Hamad S, et al. Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function. Nat Commun. 2022;13(1). doi:10.1038/s41467-022-29124-8
6.     Abudi N, Duev O, Asraf T, Blank S, Matot I, Abramovitch R. Premature Macrophage Activation by Stored Red Blood Cell Transfusion Halts Liver Regeneration Post-Partial Hepatectomy in Rats. Cells. 2022;11(21). doi:10.3390/cells11213522
7.     Dahan T, Nassar S, Yajuk O, et al. Chronic Intermittent Hypoxia during Sleep Causes Browning of Interscapular Adipose Tissue Accompanied by Local Insulin Resistance in Mice. Int J Mol Sci. 2022;23(24). doi:10.3390/ijms232415462
8.     Shriki A, Lanton T, Sonnenblick A, et al. Multiple roles of il6 in hepatic injury, steatosis, and senescence aggregate to suppress tumorigenesis. Cancer Res. 2021;81(18):4766-4777. doi:10.1158/0008-5472.CAN-21-0321
9.     Ginosar Y, Bromberg Z, Nachmanson N, et al. Chronic hypoxia in pregnant mice impairs the placental and fetal vascular response to acute hypercapnia in BOLD-MRI hemodynamic response imaging. Placenta. 2021;110:29-38. doi:10.1016/j.placenta.2021.05.006
10.     Grunewald M, Kumar S, Sharife H, et al. Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span. Science. 2021;373(6554). doi:10.1126/science.abc8479
11.     Shapiro J, Ginosar Y, Gielchinsky Y, et al. BOLD-MRI demonstrates acute placental and fetal organ hypoperfusion with fetal brain sparing in response to phenylephrine but not ephedrine. Placenta. 2020;90:52-57. doi:10.1016/j.placenta.2019.11.006
12.     Ginosar Y, Gielchinsky Y, Nachmansson N, et al. BOLD-MRI demonstrates acute placental and fetal organ hypoperfusion with fetal brain sparing during hypercapnia. Placenta. 2018;63:53-60. doi:10.1016/j.placenta.2017.09.005
13.     Klein S, Abraham M, Bulvik B, et al. CXCR4 promotes neuroblastoma growth and therapeutic resistance through miR-15a/ 16-1–mediated ERK and BCL2/Cyclin D1 pathways. Cancer Res. 2018;78(6):1471-1483. doi:10.1158/0008-5472.CAN-17-0454
14.     Fähling M, Mathia S, Scheidl J, et al. Cyclosporin a induces renal episodic hypoxia. Acta Physiol. 2017;219(3):625-639. doi:10.1111/apha.12811
15.     Lanton T, Shriki A, Nechemia-Arbely Y, et al. Interleukin 6–dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis. Hepatology. 2017;65(5):1600-1611. doi:10.1002/hep.29004
16.     Matot I, Nachmansson N, Duev O, et al. Impaired liver regeneration after hepatectomy and bleeding is associated with a shift from hepatocyte proliferation to hypertrophy. FASEB J. 2017;31(12):5283-5295. doi:10.1096/fj.201700153R
17.     Hijazi N, Fanne RA, Abramovitch R, et al. Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice. Blood. 2015;125(16):2558-2567. doi:10.1182/blood-2014-08-588442
18.     Tempel-Brami C, Schiffenbauer YS, Nyska A, et al. Practical Applications of in Vivo and ex Vivo MRI in Toxicologic Pathology Using a Novel High-performance Compact MRI System. Toxicol Pathol. 2015;43(5):633-650. doi:10.1177/0192623314568390
19.     Ginosar Y, Nachmanson NC, Shapiro J, Weissman C, Abramovitch R. Inhaled carbon dioxide causes dose-dependent paradoxical bradypnea in animals anesthetized with pentobarbital, but not with isoflurane or ketamine. Respir Physiol Neurobiol. 2015;217:1-7. doi:10.1016/j.resp.2015.06.003
20.     Zeira E, Abramovitch R, Meir K, et al. The knockdown of H19lncRNA reveals its regulatory role in pluripotency and tumorigenesis of human embryonic carcinoma cells. Oncotarget. 2015;6(33):34691-34703. doi:10.18632/oncotarget.5787
21.     Edrei Y, Freiman M, Sklair-Levy M, et al. Quantitative functional MRI biomarkers improved early detection of colorectal liver metastases. J Magn Reson Imaging. 2014;39(5):1246-1253. doi:10.1002/jmri.24270
22.     Ella E, Heim D, Stoyanov E, et al. Specific genomic and transcriptomic aberrations in tumors induced by partial hepatectomy of a chronically inflamed murine liver. Oncotarget. 2014;5(21):10318-10331. doi:10.18632/oncotarget.2515
23.     Komar-Stossel C, Gross E, Dery E, et al. TL-118 and gemcitabine drug combination display therapeutic efficacy in a mycn amplified orthotopic neuroblastoma murine model - Evaluation by MRI. PLoS One. 2014;9(3). doi:10.1371/journal.pone.0090224
24.     Milman Z, Axelrod JH, Heyman SN, Nachmansson N, Abramovitch R. Assessment with unenhanced MRI techniques of renal morphology and hemodynamic changes during acute kidney injury and chronic kidney disease in mice. Am J Nephrol. 2014;39(3):268-278. doi:10.1159/000360093
25.     Laufer H, Mazuz A, Nachmansson N, et al. Monitoring brain tumor vascular heamodynamic following anti-angiogenic therapy with advanced magnetic resonance imaging in mice. PLoS One. 2014;9(12). doi:10.1371/journal.pone.0115093
26.     Khvalevsky EZ, Gabai R, Rachmut IH, et al. Mutant KRAS is a druggable target for pancreatic cancer. Proc Natl Acad Sci U S A. 2013;110(51):20723-20728. doi:10.1073/pnas.1314307110
27.     Artzi M, Aizenstein O, Abramovitch R, Bashat DB. MRI multiparametric hemodynamic characterization of the normal brain. Neuroscience. 2013;240:269-276. doi:10.1016/j.neuroscience.2013.03.004
28.     Matot I, Katz M, Pappo O, et al. Resuscitation with aged blood exacerbates liver injury in a hemorrhagic rat model. Crit Care Med. 2013;41(3):842-849. doi:10.1097/CCM.0b013e3182711b38
29.     Milman Z, Heyman SN, Corchia N, et al. Hemodynamic response magnetic resonance imaging: Application for renal hemodynamic characterization. Nephrol Dial Transplant. 2013;28(5):1150-1156. doi:10.1093/ndt/gfs541
30.     Barashi N, Weiss ID, Wald O, et al. Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice. Hepatology. 2013;58(3):1021-1030. doi:10.1002/hep.26403
31.     Edrei Y, Gross E, Corchia N, Abramovitch R. Improved efficacy of a novel anti-angiogenic drug combination (TL-118) against colorectal-cancer liver metastases; MRI monitoring in mice. Br J Cancer. 2012;107(4):658-666. doi:10.1038/bjc.2012.322
32.     Ben Bashat D, Artzi M, Ben Ami H, et al. Hemodynamic Response Imaging: A Potential Tool for the Assessment of Angiogenesis in Brain Tumors. PLoS One. 2012;7(11). doi:10.1371/journal.pone.0049416
33.     Edrei Y, Gross E, Corchia N, et al. Vascular profile characterization of liver tumors by magnetic resonance imaging using hemodynamic response imaging in mice. Neoplasia. 2011;13(3):244-253. doi:10.1593/neo.101354
34.     Sela Y, Freiman M, Dery E, et al. FMRI-based hierarchical SVM model for the classification and grading of liver fibrosis. IEEE Trans Biomed Eng. 2011;58(9):2574-2581. doi:10.1109/TBME.2011.2159501
35.     Gielchinsky Y, Laufer N, Weitman E, et al. Pregnancy restores the regenerative capacity of the aged liver via activation of an mTORC1-controlled hyperplasia/hypertrophy switch. Genes Dev. 2010;24(6):543-548. doi:10.1101/gad.563110
36.     Freiman M, Sela Y, Edrei Y, Pappo O, Joskowicz L, Abramovitch R. Multi-class SVM model for fMRI-based classification and grading of liver fibrosis. In: R.M. S, N. K, eds. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol 7624. SPIE; 2010. doi:10.1117/12.841242
37.     Barash H, Gross ER, Edrei Y, et al. Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks. Proc Natl Acad Sci U S A. 2010;107(5):2207-2212. doi:10.1073/pnas.0908867107
38.     Cohen I, Maoz M, Turm H, et al. Etk/Bmx regulates proteinase-activated-receptor1 (PAR1) in breast cancer invasion: Signaling partners, hierarchy and physiological significance. PLoS One. 2010;5(6). doi:10.1371/journal.pone.0011135
39.     Beider K, Abraham M, Begin M, et al. Interaction between CXCR4 and CCL20 pathways regulates tumor growth. PLoS One. 2009;4(4). doi:10.1371/journal.pone.0005125
40.     Zorde-Khvalevsky E, Abramovitch R, Barash H, et al. Toll-like receptor 3 signaling attenuates liver regeneration. Hepatology. 2009;50(1):198-206. doi:10.1002/hep.22973
41.     Freiman M, Edrei Y, Gross E, Joskowicz L, Abramovitch R. Liver metastasis early detection using fMRI based statistical model. In: 2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI. ; 2008:584-587. doi:10.1109/ISBI.2008.4541063
42.     Ben Moshe T, Kang T-B, Kovalenko A, et al. Cell-autonomous and non-cell-autonomous functions of caspase-8. Cytokine Growth Factor Rev. 2008;19(3-4):209-217. doi:10.1016/j.cytogfr.2008.04.012
43.     Freiman M, Edrei Y, Sela Y, et al. Classification of suspected liver metastases using fMRI images: A machine learning approach. In: Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol 5241 LNCS. ; 2008:93-100. doi:10.1007/978-3-540-85988-8_12
44.     Matot I, Einav S, Weiniger CF, et al. Lung injury after in vivo reperfusion: Outcome at 27 hours after reperfusion. Anesthesiology. 2008;109(2):269-278. doi:10.1097/ALN.0b013e31817f5b90
45.     Matot I, Cohen K, Pappo O, Barash H, Abramovitch R. Liver response to hemorrhagic shock and subsequent resuscitation: MRI analysis. Shock. 2008;29(1):16-24. doi:10.1097/shk.0b013e3180556964
46.     Barash H, Gross E, Edrei Y, et al. Functional magnetic resonance imaging monitoring of pathological changes in rodent livers during hyperoxia and hypercapnia. Hepatology. 2008;48(4):1232-1241. doi:10.1002/hep.22394
47.     Meyuhas R, Pikarsky E, Tavor E, et al. A key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1(CYR61) in tumor cells. Mol Cancer Res. 2008;6(9):1397-1409. doi:10.1158/1541-7786.MCR-07-2086
48.     Ben Moshe T, Barash H, Kang T-B, et al. Role of caspase-8 in hepatocyte response to infection and injury in mice. Hepatology. 2007;45(4):1014-1024. doi:10.1002/hep.21495
49.     Barash H, Gross E, Matot I, et al. Functional MR imaging during hypercapnia and hyperoxia: Noninvasive tool for monitoring changes in liver perfusion and hemodynamics in a rat model. Radiology. 2007;243(3):727-735. doi:10.1148/radiol.2433060433
50.     Grunewald M, Avraham I, Dor Y, et al. VEGF-induced adult neovascularization: Recruitment, retention, and role of accessory cells. Cell. 2006;124(1):175-189. doi:10.1016/j.cell.2005.10.036
51.     Gafni Y, Zilberman Y, Ophir Z, et al. Design of a filamentous polymeric scaffold for in vivo guided angiogenesis. Tissue Eng. 2006;12(11):3021-3034. doi:10.1089/ten.2006.12.3021
52.     Grunewald M, Avraham I, Dor Y, et al. VEGF-Induced Adult Neovascularization: Recruitment, Retention, and Role of Accessory Cells (DOI:10.1016/j.cell.2005.10.036). Cell. 2006;126(4):811. doi:10.1016/j.cell.2006.08.015
53.     Cohen I, Pappo O, Elkin M, et al. Heparanase promotes growth, angiogenesis and survival of primary breast tumors. Int J Cancer. 2006;118(7):1609-1617. doi:10.1002/ijc.21552
54.     Zcharia E, Zilka R, Yaar A, et al. Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models. FASEB J. 2005;19(2):211-221. doi:10.1096/fj.04-1970com
55.     Darash-Yahana M, Pikarsky E, Abramovitch R, et al. Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis. FASEB J. 2004;18(11):1240-1242. doi:10.1096/fj.03-0935fje
56.     Pikarsky E, Porat RM, Stein I, et al. NF-κB functions as a tumour promoter in inflammation-associated cancer. Nature. 2004;431(7007):461-466. doi:10.1038/nature02924
57.     Abramovitch R, Tavor E, Jacob-Hirsch J, et al. A Pivotal Role of Cyclic AMP-Responsive Element Binding Protein in Tumor Progression. Cancer Res. 2004;64(4):1338-1346. doi:10.1158/0008-5472.CAN-03-2089
58.     Abramovitch R, Itzik A, Harel H, Nagler A, Vlodavsky I, Siegal T. Halofuginone inhibits angiogenesis and growth in implanted metastatic rat brain tumor model - An MRI study. Neoplasia. 2004;6(5):480-489. doi:10.1593/neo.03520
59.     Shabat S, Nyska A, Long PH, et al. Osteonecrosis in a Chemically Induced Rat Model of Human Hemolytic Disorders Associated with Thrombosis - A New Model for Avascular Necrosis of Bone. In: Calcified Tissue International. Vol 74. ; 2004:220-228. doi:10.1007/s00223-003-0068-7
60.     Goldshmidt O, Zcharia E, Abramovitch R, et al. Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis. Proc Natl Acad Sci U S A. 2002;99(15):10031-10036. doi:10.1073/pnas.152070599
61.     Dor Y, Djonov V, Abramovitch R, et al. Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy. EMBO J. 2002;21(8):1939-1947. doi:10.1093/emboj/21.8.1939
62.     Shaharabany M, Abramovitch R, Kushnir T, et al. In vivo molecular imaging of met tyrosine kinase growth factor receptor activity in normal organs and breast tumors. Cancer Res. 2001;61(12):4873-4878. https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035875024&partnerID=40&md5=7e679cedd7e9f7eda7780b06c17c7f7a
63.     Abramovitch R, Marikovsky M, Meir G, Neeman M. Stimulation of tumour growth by wound-derived growth factors. Br J Cancer. 1999;79(9-10):1392-1398. doi:10.1038/sj.bjc.6690223
64.     Gross DJ, Reibstein I, Weiss L, et al. The antiangiogenic agent linomide inhibits the growth rate of von Hippel-Lindau paraganglioma xenografts to mice. Clin Cancer Res. 1999;5(11):3669-3675. https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032711528&partnerID=40&md5=2cf07115672520aa36268bf7f03def8d
65.     Abramovitch R, Dafni H, Smouha E, Benjamin LE, Neeman M. In vivo prediction of vascular susceptibility to vascular endothelial growth factor withdrawal: Magnetic resonance imaging of C6 rat glioma in nude mice. Cancer Res. 1999;59(19):5012-5016. https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033214065&partnerID=40&md5=4400d69abbf29222fced17f3e3bf971a
66.     Abramovitch R, Dafni H, Neeman M, Nagler A, Pines M. Inhibition of Neovascularization and Tumor Growth, and Facilitation of Wound Repair, by Halofuginone, an Inhibitor of Collagen Type I Synthesis. Neoplasia. 1999;1(4):321-329. doi:10.1038/sj.neo.7900043
67.     Abramovitch R, Marikovsky M, Meir G, Neeman M. Stimulation of tumour angiogenesis by proximal wounds: Spatial and temporal analysis by MRI. Br J Cancer. 1998;77(3):440-447. doi:10.1038/bjc.1998.70
68.     Abramovitch R, Frenkiel D, Neeman M. Analysis of subcutaneous angiogenesis by gradient echo magnetic resonance imaging. Magn Reson Med. 1998;39(5):813-824. doi:10.1002/mrm.1910390519
69.     Carmeliet P, Dor Y, Herbert J-M, et al. Erratum: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (Nature (1998) 394 (485-490)). Nature. 1998;395(6701):525. doi:10.1038/26791
70.     Abramovitch R, Neeman M, Reich R, et al. Intercellular communication between vascular smooth muscle and endothelial cells mediated by heparin-binding epidermal growth factor-like growth factor and vascular endothelial growth factor. FEBS Lett. 1998;425(3):441-447. doi:10.1016/S0014-5793(98)00283-X
71.     Carmeliet P, Dor Y, Herber J-M, et al. Role of HIF-1α in hypoxiamediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 1998;394(6692):485-490. doi:10.1038/28867
72.     Neeman M, Abramovitch R, Schiffenbauer YS, Tempel C. Regulation of angiogenesis by hypoxic stress: From solid tumours to the ovarian follicle. Int J Exp Pathol. 1997;78(2):57-70. doi:10.1046/j.1365-2613.1997.d01-247.x
73.     Schiffenbauer YS, Abramovitch R, Meir G, et al. Loss of ovarian function promotes angiogenesis in human ovarian carcinoma. Proc Natl Acad Sci U S A. 1997;94(24):13203-13208. doi:10.1073/pnas.94.24.13203
74.     Abramovitch R, Meir G, Neeman M. Neovascularization Induced Growth of Implanted C6 Glioma Multicellular Spheroids: Magnetic Resonance Microimaging. Cancer Res. 1995;55(9):1956-1962. https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028968176&partnerID=40&md5=d2e24c2e57a5b46cd5cf625f26202c8a
75.     Schiffenbauer YS, Tempel C, Abramovitch R, Meir G, Neeman M. Cyclocreatine Accumulation Leads to Cellular Swelling in C6 Glioma Multicellular Spheroids: Diffusion and One-Dimensional Chemical Shift Nuclear Magnetic Resonance Microscopy. Cancer Res. 1995;55(1):153-158. https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028963228&partnerID=40&md5=dadf3da9e76366a896db8d76cb948d88