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Hadassah Medical Center - Gene Therapy: Peled Amnon


Last updated September 2023 - Gene Therapy

List of Publications


Stern E, Pines G, Lazar LO, Vainer GW, Beltran N, Dodi O, et al. CDC25C Protein Expression Correlates with Tumor Differentiation and Clinical Outcomes in Lung Adenocarcinoma. Biomedicines [Internet]. 2023;11(2). Available from:


Greenman R, Segal-Salto M, Barashi N, Hay O, Katav A, Levi O, et al. CCL24 regulates biliary inflammation and fibrosis in primary sclerosing cholangitis. JCI Insight [Internet]. 2023;8(12). Available from:


Rosenberg N, Van Haele M, Lanton T, Brashi N, Bromberg Z, Adler H, et al. Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling. Journal of Hepatology [Internet]. 2022;77(6):1631–41. Available from:


Beider K, Voevoda-Dimenshtein V, Zoabi A, Rosenberg E, Magen H, Ostrovsky O, et al. CXCL13 chemokine is a novel player in multiple myeloma osteolytic microenvironment, M2 macrophage polarization, and tumor progression. Journal of Hematology and Oncology [Internet]. 2022;15(1). Available from:


Cendrowicz E, Jacob L, Greenwald S, Tamir A, Pecker I, Tabakman R, et al. DSP107 combines inhibition of CD47/SIRPα axis with activation of 4-1BB to trigger anticancer immunity. Journal of Experimental and Clinical Cancer Research [Internet]. 2022;41(1). Available from:


Paldor M, Levkovitch-Siany O, Eidelshtein D, Adar R, Enk CD, Marmary Y, et al. Single-cell transcriptomics reveals a senescence-associated IL-6/CCR6 axis driving radiodermatitis. EMBO Molecular Medicine [Internet]. 2022;14(8). Available from:


Rodionov G, Rosenzwaig M, Tzadok MS, Kvint M, Gevir E, Zorde-Khvalevsky E, et al. Short treatment of peripheral blood cells product with Fas ligand using closed automated cell processing system significantly reduces immune cell reactivity of the graft in vitro and in vivo. Bone Marrow Transplantation [Internet]. 2022;57(8):1250–9. Available from:


Bockorny B, Macarulla T, Semenisty V, Borazanci E, Feliu J, Ponz-Sarvise M, et al. Motixafortide and pembrolizumab combined to nanoliposomal irinotecan, fluorouracil, and folinic acid in metastatic pancreatic cancer: The COMBAT/ KEYNOTE-202 trial. Clinical Cancer Research [Internet]. 2021;27(18):5020–7. Available from:


Shriki A, Lanton T, Sonnenblick A, Levkovitch-Siany O, Eidelshtein D, Abramovitch R, et al. Multiple roles of il6 in hepatic injury, steatosis, and senescence aggregate to suppress tumorigenesis. Cancer Research [Internet]. 2021;81(18):4766–77. Available from:


Borthakur G, Ofran Y, Tallman MS, Foran J, Uy GL, DiPersio JF, et al. BL-8040 CXCR4 antagonist is safe and demonstrates antileukemic activity in combination with cytarabine for the treatment of relapsed/refractory acute myelogenous leukemia: An open-label safety and efficacy phase 2a study. Cancer [Internet]. 2021;127(8):1246–59. Available from:


Becker-Herman S, Rozenberg M, Hillel-Karniel C, Gil-Yarom N, Kramer M, Barak A, et al. CD74 is a regulator of hematopoietic stem cell maintenance. PLoS Biology [Internet]. 2021;19(3). Available from:


Beider K, Rosenberg E, Dimenshtein-Voevoda V, Sirovsky Y, Vladimirsky J, Magen H, et al. Blocking of Transient Receptor Potential Vanilloid 1 (TRPV1) promotes terminal mitophagy in multiple myeloma, disturbing calcium homeostasis and targeting ubiquitin pathway and bortezomib-induced unfolded protein response. Journal of Hematology and Oncology [Internet]. 2020;13(1). Available from:


Levy-Barazany H, Shachnai-Pinkas L, Rodionov G, Saar A, Rosenzwaig M, Gez L, et al. Brief ex vivo Fas-ligand incubation attenuates GvHD without compromising stem cell graft performance. Bone Marrow Transplantation [Internet]. 2020;55(7):1305–16. Available from:


Bockorny B, Semenisty V, Macarulla T, Borazanci E, Wolpin BM, Stemmer SM, et al. BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial. Nature Medicine [Internet]. 2020;26(6):878–85. Available from:


Beider K, Bitner H, Voevoda-Dimenshtein V, Rosenberg E, Sirovsky Y, Magen H, et al. The mTOR inhibitor everolimus overcomes CXCR4-mediated resistance to histone deacetylase inhibitor panobinostat through inhibition of p21 and mitotic regulators. Biochemical Pharmacology [Internet]. 2019;168:412–28. Available from:


Hagbi-Levi S, Abraham M, Tiosano L, Rinsky B, Grunin M, Eizenberg O, et al. Promiscuous Chemokine Antagonist (BKT130) Suppresses Laser-Induced Choroidal Neovascularization by Inhibition of Monocyte Recruitment. Journal of Immunology Research [Internet]. 2019;2019. Available from:


Peled A, Klein S, Beider K, Burger JA, Abraham M. Role of CXCL12 and CXCR4 in the pathogenesis of hematological malignancies. Cytokine [Internet]. 2018;109:11–6. Available from:


Ella E, Harel Y, Abraham M, Wald H, Benny O, Karsch-Bluman A, et al. Matrix metalloproteinase 12 promotes tumor propagation in the lung. Journal of Thoracic and Cardiovascular Surgery [Internet]. 2018;155(5):2164-2175.e1. Available from:


Klein S, Abraham M, Bulvik B, Dery E, Weiss ID, Barashi N, et al. CXCR4 promotes neuroblastoma growth and therapeutic resistance through miR-15a/ 16-1–mediated ERK and BCL2/Cyclin D1 pathways. Cancer Research [Internet]. 2018;78(6):1471–83. Available from:


Peled A, Nagler A. NK cell destiny after haploSCT with PT-Cy. Blood [Internet]. 2018;131(2):161–2. Available from:


Abraham M, Wald H, Vaizel-Ohayon D, Grabovsky V, Oren Z, Karni A, et al. Development of novel promiscuous anti-chemokine peptibodies for treating autoimmunity and inflammation. Frontiers in Immunology [Internet]. 2017;8(NOV). Available from:


Abraham M, Pereg Y, Bulvik B, Klein S, Mishalian I, Wald H, et al. Single dose of the CXCR4 antagonist BL-8040 induces rapid mobilization for the collection of human CD34 + cells in healthy volunteers. Clinical Cancer Research [Internet]. 2017;23(22):6790–801. Available from:


Abraham M, Klein S, Bulvik B, Wald H, Weiss ID, Olam D, et al. The CXCR4 inhibitor BL-8040 induces the apoptosis of AML blasts by downregulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression. Leukemia [Internet]. 2017;31(11):2336–46. Available from:


Abraham M, Karni A, Mausner-Fainberg K, Weiss ID, Peled A. Natural and induced immunization against CCL20 ameliorate experimental autoimmune encephalitis and may confer protection against multiple sclerosis. Clinical Immunology [Internet]. 2017;183:316–24. Available from:


Lanton T, Shriki A, Nechemia-Arbely Y, Abramovitch R, Levkovitch O, Adar R, et al. Interleukin 6–dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis. Hepatology [Internet]. 2017;65(5):1600–11. Available from:


Beider K, Rosenberg E, Bitner H, Shimoni A, Leiba M, Koren-Michowitz M, et al. The sphingosine-1-phosphate modulator FTY720 targets multiple myeloma via the CXCR4/CXCL12 pathway. Clinical Cancer Research [Internet]. 2017;23(7):1733–47. Available from:


Hagbi-Levi S, Grunin M, Jaouni T, Tiosano L, Rinsky B, Elbaz-Hayoun S, et al. Proangiogenic characteristics of activated macrophages from patients with age-related macular degeneration. Neurobiology of Aging [Internet]. 2017;51:71–82. Available from:


Randhawa S, Cho BS, Ghosh D, Sivina M, Koehrer S, Müschen M, et al. Effects of pharmacological and genetic disruption of CXCR4 chemokine receptor function in B-cell acute lymphoblastic leukaemia. British Journal of Haematology [Internet]. 2016;174(3):425–36. Available from:


Matza D, Badou A, Klemic KG, Stein J, Govindarajulu U, Nadler MJ, et al. T cell receptor mediated calcium entry requires alternatively spliced Cav1.1 channels. PLoS ONE [Internet]. 2016;11(1). Available from:


Weiss ID, Ella E, Dominsky O, Smith Y, Abraham M, Wald H, et al. In the hunt for therapeutic targets: Mimicking the growth, metastasis, and stromal associations of early-stage lung cancer using a novel orthotopic animal model. Journal of Thoracic Oncology [Internet]. 2015;10(1):46–58. Available from:


Horwitz ME, Chao NJ, Rizzieri DA, Long GD, Sullivan KM, Gasparetto C, et al. Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment. Journal of Clinical Investigation [Internet]. 2014;124(7):3121–8. Available from:


Peled A, Abraham M, Avivi I, Rowe JM, Beider K, Wald H, et al. The high-affinity CXCR4 antagonist BKT140 is safe and induces a robust mobilization of human CD34+ cells in patients with multiple myeloma. Clinical Cancer Research [Internet]. 2014;20(2):469–79. Available from:


Beider K, Bitner H, Leiba M, Gutwein O, Koren-Michowitz M, Ostrovsky O, et al. Multiple myeloma cells recruit tumor-supportive macrophages through the CXCR4/CXCL12 axis and promote their polarization toward the M2 phenotype. Oncotarget [Internet]. 2014;5(22):11283–96. Available from:


Beider K, Darash-Yahana M, Blaier O, Koren-Michowitz M, Abraham M, Wald H, et al. Combination of imatinib with CXCR4 Antagonist BKT140 overcomes the protective effect of stroma and targets CML in vitro and in vivo. Molecular Cancer Therapeutics [Internet]. 2014;13(5):1155–69. Available from:


Abraham M, Weiss ID, Wald H, Wald O, Nagler A, Beider K, et al. Sequential administration of the high affinity CXCR4 antagonist BKT140 promotes megakaryopoiesis and platelet production. British Journal of Haematology [Internet]. 2013;163(2):248–59. Available from:


Peled A, Tavor S. Role of CXCR4 in the pathogenesis of acute myeloid leukemia. Theranostics [Internet]. 2013;3(1):34–9. Available from:


Barashi N, Weiss ID, Wald O, Wald H, Beider K, Abraham M, et al. Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice. Hepatology [Internet]. 2013;58(3):1021–30. Available from:


Beider K, Ribakovsky E, Abraham M, Wald H, Weiss L, Rosenberg E, et al. Targeting the CD20 and CXCR4 pathways in non-hodgkin lymphoma with rituximab and high-affinity CXCR4 antagonist BKT140. Clinical Cancer Research [Internet]. 2013;19(13):3495–507. Available from:


Potikha T, Stoyanov E, Pappo O, Frolov A, Mizrahi L, Olam D, et al. Interstrain differences in chronic hepatitis and tumor development in a murine model of inflammation-mediated hepatocarcinogenesis. Hepatology [Internet]. 2013;58(1):192–204. Available from:


Eldor R, Abel R, Sever D, Sadoun G, Peled A, Sionov R, et al. Inhibition of Nuclear Factor-κB Activation in Pancreatic β-Cells Has a Protective Effect on Allogeneic Pancreatic Islet Graft Survival. PLoS ONE [Internet]. 2013;8(2). Available from:


Peled A. Microenvironmental mediators as therapeutic targets in malignancy [Internet]. The Inflammatory Milieu of Tumors: Cytokines and Chemokines that Affect Tumor Growth and Metastasis. 2012. Available from:


Fahham D, Weiss ID, Abraham M, Beider K, Hanna W, Shlomai Z, et al. In vitro and in vivo therapeutic efficacy of CXCR4 antagonist BKT140 against human non–small cell lung cancer. Journal of Thoracic and Cardiovascular Surgery [Internet]. 2012;144(5):1167-1175.e1. Available from:


Grunin M, Burstyn-Cohen T, Hagbi-Levi S, Peled A, Chowers I. Chemokine receptor expression in peripheral blood monocytes from patients with neovascular age-related macular degeneration. Investigative Ophthalmology and Visual Science [Internet]. 2012;53(9):5292–300. Available from:


Peled A, Wald O, Burger J. Development of novel CXCR4-based therapeutics. Expert Opinion on Investigational Drugs [Internet]. 2012;21(3):341–53. Available from:


Jacobson O, Weiss ID, Szajek LP, Niu G, Ma Y, Kiesewetter DO, et al. Improvement of CXCR4 tracer specificity for PET imaging. Journal of Controlled Release [Internet]. 2012;157(2):216–23. Available from:


Peled A, Nagler A. Role of the CXCR4/CXCL12 axis in hematopoietic stem cell trafficking [Internet]. Novel Developments in Stem Cell Mobilization: Focus on CXCR4. 2012. Available from:


Josefsberg Ben-Yehoshua L, Beider K, Shimoni A, Ostrovsky O, Samookh M, Peled A, et al. Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death. PloS one [Internet]. 2012;7(4). Available from:


Peled T, Shoham H, Aschengrau D, Yackoubov D, Frei G, Rosenheimer G N, et al. Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment. Experimental Hematology [Internet]. 2012;40(4):342-355.e1. Available from:


Mishalian I, Ordan M, Peled A, Maly A, Eichenbaum MB, Ravins M, et al. Recruited macrophages control dissemination of group A Streptococcus from infected soft tissues. Journal of Immunology [Internet]. 2011;187(11):6022–31. Available from:


Kirshberg S, Izhar U, Amir G, Demma J, Vernea F, Beider K, et al. Involvement of CCR6/CCL20/IL-17 axis in NSCLC disease progression. PLoS ONE [Internet]. 2011;6(9). Available from:


Wald O, Izhar U, Amir G, Kirshberg S, Shlomai Z, Zamir G, et al. Interaction between neoplastic cells and cancer-associated fibroblasts through the CXCL12/CXCR4 axis: Role in non-small cell lung cancer tumor proliferation. Journal of Thoracic and Cardiovascular Surgery [Internet]. 2011;141(6):1503–12. Available from:


Weiss ID, Shoham H, Wald O, Wald H, Beider K, Abraham M, et al. Ccr5 deficiency regulates the proliferation and trafficking of natural killer cells under physiological conditions. Cytokine [Internet]. 2011;54(3):249–57. Available from:


Burger JA, Stewart DJ, Wald O, Peled A. Potential of CXCR4 antagonists for the treatment of metastatic lung cancer. Expert Review of Anticancer Therapy [Internet]. 2011;11(4):621–30. Available from:


Beider K, Begin M, Abraham M, Wald H, Weiss ID, Wald O, et al. CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth. Experimental Hematology [Internet]. 2011;39(3):282–92. Available from:


Weiss ID, Wald O, Wald H, Beider K, Abraham M, Galun E, et al. IFN-γ treatment at early stages of influenza virus infection protects mice from death in a NK cell-dependent manner. Journal of Interferon and Cytokine Research [Internet]. 2010;30(6):439–49. Available from:


Rudich N, Zamir G, Pappo O, Shlomai Z, Faroja M, Weiss ID, et al. Focal liver necrosis appears early after partial hepatectomy and is dependent on T cells and antigen delivery from the gut. Liver International [Internet]. 2009;29(8):1273–84. Available from:


Darash-Yahana M, Gillespie JW, Hewitt SM, Chen YYK, Maeda S, Stein I, et al. The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers. PLoS ONE [Internet]. 2009;4(8). Available from:


Hayun M, Saida H, Albeck M, Peled A, Haran-Ghera N, Sredni B. Induction therapy in a multiple myeloma mouse model using a combination of AS101 and melphalan, and the activity of AS101 in a tumor microenvironment model. Experimental Hematology [Internet]. 2009;37(5):593–603. Available from:


Beider K, Abraham M, Begin M, Wald H, Weiss ID, Wald O, et al. Interaction between CXCR4 and CCL20 pathways regulates tumor growth. PLoS ONE [Internet]. 2009;4(4). Available from:


Abraham M, Beider K, Wald H, Weiss ID, Zipori D, Galun E, et al. The CXCR4 antagonist 4F-benzoyl-TN14003 stimulates the recovery of the bone marrow after transplantation. Leukemia [Internet]. 2009;23(8):1378–88. Available from:


Burger JA, Peled A. CXCR4 antagonists: Targeting the microenvironment in leukemia and other cancers. Leukemia [Internet]. 2009;23(1):43–52. Available from:


Lapidot A, Peled A, Berchanski A, Pal B, Kollet O, Lapidot T, et al. NeoR6 inhibits HIV-1-CXCR4 interaction without affecting CXCL12 chemotaxis activity. Biochimica et Biophysica Acta - General Subjects [Internet]. 2008;1780(6):914–20. Available from:


Beider K, Abraham M, Peled A. Chemokines and chemokine receptors in stem cell circulation. Frontiers in Bioscience [Internet]. 2008;13(17):6820–33. Available from:


Abraham M, Biyder K, Begin M, Wald H, Weiss ID, Galun E, et al. Enhanced unique pattern of hematopoietic cell mobilization induced by the CXCR4 antagonist 4f-benzoyl-TN14003. Stem Cells [Internet]. 2007;25(9):2158–66. Available from:


Wald O, Weiss ID, Galun E, Peled A. Chemokines in hepatitis C virus infection: Pathogenesis, prognosis and therapeutics. Cytokine [Internet]. 2007;39(1):50–62. Available from:


Gavish M, Peled A, Chor B. Genetic code symmetry and efficient design of GC-constrained coding sequences. Bioinformatics [Internet]. 2007;23(2):e57–63. Available from:


Hayun M, Naor Y, Weil M, Albeck M, Peled A, Don J, et al. The immunomodulator AS101 induces growth arrest and apoptosis in Multiple Myeloma: Association with the Akt/Survivin pathway. Biochemical Pharmacology [Internet]. 2006;72(11):1423–31. Available from:


Wald O, Izhar U, Amir G, Avniel S, Bar-Shavit Y, Wald H, et al. CD4+CXCR4highCD69+ T cells accumulate in lung adenocarcinoma. Journal of immunology (Baltimore, Md : 1950) [Internet]. 2006;177(10):6983–90. Available from:


Hidalgo-Grass C, Mishalian I, Dan-Goor M, Belotserkovsky I, Eran Y, Nizet V, et al. A streptococcal protease that degrades CXC chemokines and impairs bacterial clearance from infected tissues. EMBO Journal [Internet]. 2006;25(19):4628–37. Available from:


Dagan-Berger M, Feniger-Barish R, Avniel S, Wald H, Galun E, Grabovsky V, et al. Role of CXCR3 carboxyl terminus and third intracellular loop in receptor-mediated migration, adhesion and internalization in response to CXCL11. Blood [Internet]. 2006;107(10):3821–31. Available from:


Wald O, Weiss ID, Wald H, Shoham H, Bar-Shavit Y, Beider K, et al. IFN-γ acts on T cells to induce NK cell mobilization and accumulation in target organs. Journal of Immunology [Internet]. 2006;176(8):4716–29. Available from:


Eldor R, Yeffet A, Baum K, Doviner V, Amar D, Ben-Neriah Y, et al. Conditional and specific NF-κB blockade protects pancreatic beta cells from diabetogenic agents. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2006;103(13):5072–7. Available from:


Avniel S, Arik Z, Maly A, Sagie A, Basst HB, Yahana MD, et al. Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burns. Journal of Investigative Dermatology [Internet]. 2006;126(2):468–76. Available from:


Ahlenstiel G, Iwan A, Nattermann J, Bueren K, Rockstroh JK, Brackman HH, et al. Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study. World Journal of Gastroenterology [Internet]. 2005;11(48):7631–8. Available from:


Byk T, Kahn J, Kollet O, Petit I, Samira S, Shivtiel S, et al. Cycling G1 CD34+/CD38+ cells potentiate the motility and engraftment of quiescent G0 CD34+/CD38-/low severe combined immunodeficiency repopulating cells. Stem Cells [Internet]. 2005;23(4):561–74. Available from:


Petit I, Goichberg P, Spiegel A, Peled A, Brodie C, Seger R, et al. Atypical PKC-ζ regulates SDF-1-mediated migration and development of human CD34+ progenitor cells. Journal of Clinical Investigation [Internet]. 2005;115(1):168–76. Available from:


Wald O, Pappo O, Ari ZB, Azzaria E, Wiess ID, Gafnovitch I, et al. The CCR5Δ32 allele is associated with reduced liver inflammation in hepatitis C virus infection. European Journal of Immunogenetics [Internet]. 2004;31(6):249–52. Available from:


Darash-Yahana M, Pikarsky E, Abramovitch R, Zeira E, Pal B, Karplus R, et al. Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis. FASEB Journal [Internet]. 2004;18(11):1240–2. Available from:


Franitza S, Grabovsky V, Wald O, Weiss I, Beider K, Dagan M, et al. Differential usage of VLA-4 and CXCR4 by CD3+CD56+ NKT cells and CD56+CD16+ NK cells regulates their interaction with endothelial cells. European Journal of Immunology [Internet]. 2004;34(5):1333–41. Available from:


Spiegel A, Kollet O, Peled A, Abel L, Nagler A, Bielorai B, et al. Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling. Blood [Internet]. 2004;103(8):2900–7. Available from:


Avigdor A, Goichberg P, Shivtiel S, Dar A, Peled A, Samira S, et al. CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow. Blood [Internet]. 2004;103(8):2981–9. Available from:


Wald O, Pappo O, Safadi R, Dagan-Berger M, Beider K, Wald H, et al. Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus. European Journal of Immunology [Internet]. 2004;34(4):1164–74. Available from:


Samira S, Ferrand C, Peled A, Nagler A, Tovbin Y, Ben-Hur H, et al. Tumor necrosis factor promotes human T-cell development in nonobese diabetic/severe combined immunodeficient mice. Stem Cells [Internet]. 2004;22(6):1085–100. Available from:


Beider K, Nagler A, Wald O, Franitza S, Dagan-Berger M, Wald H, et al. Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T cells to the bone marrow and spleen of NOD/SCID mice. Blood [Internet]. 2003;102(6):1951–8. Available from:


Hanna J, Wald O, Goldman-Wohl D, Prus D, Markel G, Gazit R, et al. CXCL12 expression by invasive trophoblasts induces the specific migration of CD16- human natural killer cells. Blood [Internet]. 2003;102(5):1569–77. Available from:


Kollet O, Petit I, Kahn J, Samira S, Dar A, Peled A, et al. Human CD34+CXCR4- sorted cells harbor intracellular CXCR4, which can be functionally expressed and provide NOD/SCID repopulation. Blood [Internet]. 2002;100(8):2778–86. Available from:


Peled A, Hardan I, Trakhtenbrot L, Gur E, Magid M, Darash-Yahana M, et al. Immature leukemic CD34+CXCR4+ cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1. Stem Cells [Internet]. 2002;20(3):259–66. Available from:


Yam D, Peled A, Shinitzky M. Suppression of tumor growth and metastasis by dietary fish oil combined with vitamins E and C and cisplatin. Cancer Chemotherapy and Pharmacology [Internet]. 2001;47(1):34–40. Available from:


Kollet O, Spiegel A, Peled A, Petit I, Byk T, Hershkoviz R, et al. Rapid and efficient homing of human CD34+CD38-/lowCXCR4+ stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2mnull mice. Blood [Internet]. 2001;97(10):3283–91. Available from:


Mittelman M, Neumann D, Peled A, Kanter P, Haran-Ghera N. Erythropoietin induces tumor regression and antitumor immune responses in murine myeloma models. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2001;98(9):5181–6. Available from:


Grabovsky V, Feigelson S, Chen C, Bleijs DA, Peled A, Cinamon G, et al. Subsecond induction of α4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions. Journal of Experimental Medicine [Internet]. 2000;192(4):495–505. Available from:


Gonzalo JA, Lloyd CM, Peled A, Delaney T, Coyle AJ, Gutierrez-Ramos JC. Critical involvement of the chemotactic axis CXCR4/stromal cell-derived factor-1α in the inflammatory component of allergic airway disease. Journal of Immunology [Internet]. 2000;165(1):499–508. Available from:


Peled A, Kollet O, Ponomaryov T, Petit I, Franitza S, Grabovsky V, et al. The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34+ cells: Role in transendothelial/stromal migration and engraftment of NOD/SCID mice. Blood [Internet]. 2000;95(11):3289–96. Available from:


Kollet O, Peled A, Byk T, Ben-Hur H, Greiner D, Shultz L, et al. β2 microglobulin-deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function. Blood [Internet]. 2000;95(10):3102–5. Available from:


Goldman Y, Peled A, Shinitzky M. Effective elimination of lung metastases induced by tumor cells treated with hydrostatic pressure and N-acetyl-L-cysteine. Cancer Research [Internet]. 2000;60(2):350–8. Available from:


Ponomaryov T, Peled A, Petit I, Taichman RS, Habler L, Sandbank J, et al. Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function. Journal of Clinical Investigation [Internet]. 2000;106(11):1331–9. Available from:


Peled A, Petit I, Kollet O, Magid M, Ponomaryov T, Byk T, et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science [Internet]. 1999;283(5403):845–8. Available from:


Peled A, Leykin I, Deckmann M, Shinitzky M. Evaluation of immune memory of human lymphocytes engrafted in SCID mice. Immunobiology [Internet]. 1999;201(1):145–50. Available from:


Peled A, Grabovsky V, Habler L, Sandbank J, Arenzana-Seisdedos F, Petit I, et al. The chemokine SDF-1 stimulates integrin-mediated arrest of CD34+ cells on vascular endothelium under shear flow. Journal of Clinical Investigation [Internet]. 1999;104(9):1199–211. Available from:


Peled A, Gonzalo JA, Lloyd C, Gutierrez-Ramos JC. The chemotactic cytokine Eotaxin acts as a granulocyte-macrophage colony-stimulating factor during lung inflammation. Blood [Internet]. 1998;91(6):1909–16. Available from:


Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, et al. Erratum: SA-1, a nuclear protein encoded by one member of a novel gene family: Molecular cloning and detection in hemopoietic organs (Gene (1997) 195 (151-159)). Gene [Internet]. 1998;206(2):283–5. Available from:


Wolkowicz R, Peled A, Elkind NB, Rotter V. DNA-binding activity of wild-type p53 protein is mediated by the central part of the molecule and controlled by its C terminus. Cancer Detection and Prevention [Internet]. 1998;22(1):1–13. Available from:


Daniel Y, Peled A, Huszar M, Shinitzky M. Dietary fish oil suppresses tumor growth and metastasis of Lewis lung carcinoma in mice. Journal of Nutritional Biochemistry [Internet]. 1997;8(11):619–22. Available from:


Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, et al. SA-1, a nuclear protein encoded by one member of a novel gene family: Molecular cloning and detection in hemopoietic organs. Gene [Internet]. 1997;195(2):151–9. Available from:


Haran-Ghera N, Krautghamer R, Lapidot T, Peled A, Dominguez MG, Stanley ER. Increased circulating colony-stimulating factor-1 (CSF-1) in SJL/J mice with radiation-induced acute myeloid leukemia (AML) is associated with autocrine regulation of AML cells by CSF-1. Blood [Internet]. 1997;89(7):2537–45. Available from:


Almog N, Li R, Peled A, Schwartz D, Wolkowicz R, Goldfinger N, et al. The murine C’-terminally alternatively spliced form of p53 induces attenuated apoptosis in myeloid cells. Molecular and Cellular Biology [Internet]. 1997;17(2):713–22. Available from:


Peled A, Shezen E, Schwartz D, Shav-Tal Y, Kushtai G, Lee BC, et al. Nuclear antigen expressed by proliferating cells. Hybridoma [Internet]. 1997;16(4):325–34. Available from:


Schwartz D, Almog N, Peled A, Goldfinger N, Rotter V. Role of wild type p53 in the G2 phase: Regulation of the γ-irradiation-induced delay and DNA repair. Oncogene [Internet]. 1997;15(21):2597–607. Available from:


Aparicio J, Bilbao D, Aracil M, Peled A, Zipori D, Jochems G. The murine stromal cell line 14F1.1 secretes A putative novel growth factor for progenitor cells. Experimental Hematology [Internet]. 1996;24(9):1118. Available from:


Peled A, Schwartz D, Elkind NB, Wolkowicz R, Li R, Rotter V. The role of p53 in the induction of polyploidity of myelomonocytic leukemic M1/2 cells. Oncogene [Internet]. 1996;13(8):1677–85. Available from:


Peled A, Zipori D, Rotter V. Cooperation between p53-dependent and p53-independent apoptotic pathways in myeloid cells. Cancer Research [Internet]. 1996;56(9):2148–56. Available from:


Sternberg D, Peled A, Shezen E, Abramsky O, Jiang W, Bertolero F, et al. Control of stroma-dependent hematopoiesis by basic fibroblast growth factor: Stromal phenotypic plasticity and modified myelopoietic functions. Cytokines and Molecular Therapy [Internet]. 1996;2(1):29–38. Available from:


Lee BC, Shav-Tal Y, Peled A, Gothelf Y, Jiang W, Toledo J, et al. A hematopoietic organ-specific 49-kD nuclear antigen: Predominance in immature normal and tumor granulocytes and detection in hematopoietic precursor cells. Blood [Internet]. 1996;87(6):2283–91. Available from:


Peled A, Lee BC, Sternberg D, Toledo J, Aracil M, Zipori D. Interaction between leukemia cells and bone marrow stromal cellss: Stroma-supported growth vs. serum dependence and the roles of TGF-β and M-CSF. Experimental Hematology [Internet]. 1996;24(6):728–37. Available from:


Wolkowicz R, Peled A, Elkind NB, Rotter V. Augmented DNA-binding activity of p53 protein encoded by a carboxyl-terminal alternatively spliced mRNA is blocked by p53 protein encoded by the regularly spliced form. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 1995;92(15):6842–6. Available from:


Haran-Ghera N, Peled A, Wu L, Shortman K, Brightman BK, Fan H. The effects of passive antiviral immunotherapy in AKR mice: I. The susceptibility of AKR mice to spontaneous and induced t cell lymphomagenesis. Leukemia [Internet]. 1995;9(7):1199–206. Available from:


Peled A, Tzehoval E, Haran-Ghera N. Role of cytokines in termination of the B cell lymphoma dormant state in AKR mice. Leukemia [Internet]. 1995;9(6):1095–101. Available from:


Haran-Ghera N, Peled A, Canaani E, Caspi Y, Haimovich J, Shaft D, et al. The effects of passive anti-viral immunotherapy in AKR mice: II susceptibility to B cell lymphomagenesis. Leukemia [Internet]. 1995;9(11):1940–7. Available from:


Benayahu D, Peled A, Zipori D. Myeloblastic cell line expresses osteoclastic properties following coculture with marrow stromal adipocytes. Journal of Cellular Biochemistry [Internet]. 1994;56(3):374–84. Available from:


Rosner A, Peled A, Haran-Ghera N, Canaani E. Analysis of Ly-1+ B-Cell Populations and IgH Rearrangements in “Normal” Spleens and in Lymphomas of AKR/J and AKR Fv-1b Mice. Cancer Research [Internet]. 1993;53(9):2147–53. Available from:


Haran-Ghera N, Peled A, Kay Brightman B, Fan H. Lymphomagenesis in AKRJ?v-lb Congenic Mice. Cancer Research [Internet]. 1993;53(14):3433–8. Available from:


Defresne MP, Borremans B, Verhofstede C, Peled A, Thiry A, Greimers R, et al. Mixed phenotype murine leukemias. Leukemia [Internet]. 1993;7(8):1253–60. Available from:


Resnitzky P, Goren T, Shaft D, Trakhtenbrot L, Peled A, Resnitzky D, et al. Absence of negative growth regulation in three new murine radiation-induced myeloid leukemia cell lines with deletion of chromosome 2. Leukemia [Internet]. 1992;6(12):1288–95. Available from:


Haran-Ghera N, Peled A, Krautghamer R, Resnitzky P. Initiation and promotion in radiation-induced myeloid leukemia. Leukemia [Internet]. 1992;6(7):689–95. Available from:


Irlin Y, Peled A. Thy-1 antigen-mediated adhesion of mouse lymphoid cells to stromal cells of haemopoetic origin. Immunology Letters [Internet]. 1992;33(3):233–7. Available from:


Haran-Ghera N, Peled A, Brightman BK, Fan H. Termination of the B cell lymphoma dormant state in thymectomized AKR mice. Journal of Immunology [Internet]. 1992;148(9):2947–52. Available from:


Halevy O, Rodel J, Peled A, Oren M. Frequent p53 mutations in chemically induced murine fibrosarcoma. Oncogene [Internet]. 1991;6(9):1593–600. Available from:


Peled A, Kalai M, Toledo J, Zipori D. Stroma-cell dependent hematopoiesis. Seminars in Hematology [Internet]. 1991;28(2):132–7. Available from:


Shaulsky G, Goldfinger N, Peled A, Rotter V. Involvement of wild-type p53 protein in the cell cycle requires nuclear localization. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research [Internet]. 1991;2(12):661–7. Available from:


Shaulsky G, Goldfinger N, Peled A, Rotter V. Involvement of wild-type p53 in pre-B-cell differentiation in vitro. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 1991;88(20):8982–6. Available from:


Haran-Ghera N, Peled A. II. Prevention of spontaneous AKR T cell lymphomagenesis by elimination of potential lymphoma cells with antibody to specific gp 71 determinants. Virology [Internet]. 1991;181(2):536–40. Available from:


Peled A, Haran-Ghera N. I. Prevention of spontaneous AKR T cell lymphomagenesis by 24-666, a virus isolated from an AKR B cell lymphoma. Virology [Internet]. 1991;181(2):528–35. Available from:


Haran-Ghera N, Peled A. Validity of the in vitro system as a correlate of the in vivo model of RadLV lymphomagenesis. Leukemia [Internet]. 1991;5(6):500–3. Available from:


Peled A, Zipori D, Abramsky O, Ovadia H, Shezen E. Expression of α-smooth muscle actin in murine bone marrow stromal cells. Blood [Internet]. 1991;78(2):304–9. Available from:


Gokhman I, Peled A, Haran-Ghera N. Characteristics of Potential Lymphoma-inducing Cells in Mice Sensitive or Resistant to Lymphomagenesis by Radiation Leukemia Virus Variants. Cancer Research [Internet]. 1990;50(9):2554–61. Available from:


Haran-Ghera N, Trakhtenbrot L, Resnitzky P, Peled A. Preleukemia in experimental leukemogenesis. Haematology and blood transfusion [Internet]. 1989;32:243–9. Available from:


Peled A, Haran-Ghera N. Intervention in potential leukemic cell migration pathway affects leukemogenesis. Haematology and blood transfusion [Internet]. 1989;32:237–42. Available from:


Peled A, Haran-Ghera N. Prevention of T-cell lymphoma in AKR/J mcie. Leukemia [Internet]. 1988;2(12 SUPPL.):125s–31s. Available from:


Resnitzky P, Bustan A, Peled A, Marikovsky Y. Variations in surface charge distribution of leukemic and non-leukemic transformed cells. Leukemia Research [Internet]. 1988;12(4):315–20. Available from:


Haran-Ghera N, Peled A, Leef F, Hoffman AD, Levy JA. Enhanced AKR leukemogenesis by the dual tropic viruses. I. The time and site of origin of potential leukemic cells. Leukemia [Internet]. 1987;1(5):442–9. Available from:


Peled A, Hoffman AD, Levy JA, Haran-Ghera N. Enhanced AKR leukemogenesis by the dual tropic viruses. II. Effect on cell-mediated immune responses. Leukemia [Internet]. 1987;1(5):450–6. Available from:


Trakhtenbrot L, Peled A, Haran‐Ghera N. Cytogenetic studies on B‐cell leukemias of akr origin. International Journal of Cancer [Internet]. 1987;39(3):380–4. Available from:


Peled A, Haran-Ghera N. High incidence of b cell lymphomas derived from thymectomized akr mice expressing TL.4 antigen. Journal of Experimental Medicine [Internet]. 1985;162(3):1081–6. Available from:


Katz E, Peled A, Haran-Ghera N. Changes of H-2 antigen expression on thymocytes during leukemia development by radiation leukemia virus. Leukemia Research [Internet]. 1985;9(10):1219–25. Available from:


Peled A, Haran‐Ghera N. Age‐related expression of TL antigen in AKR/J mice. International Journal of Cancer [Internet]. 1984;34(1):121–6. Available from:


Weinberger A, Peled A, Haran-Ghera N, Hazaz B, Joshua H, Pinkhas J. Infiltration of leukemic cells into muscles adjacent to joints of mice with leukemia. Israel Journal of Medical Sciences [Internet]. 1982;18(10):1057–9. Available from:


Peled A, Perk K, Haran-Ghera N, Chirigos MA. The oncostatic effect of methyl-CCNU on various experimental lymphoreticular neoplasms. Leukemia Research [Internet]. 1982;6(1):89–95. Available from:


Lonai P, Katz E, Peled A, Haran-Ghera N. H-2I-linked control of immunological resistance to viral leukemogenesis as a response to preleukemic cells. Immunogenetics [Internet]. 1981;12(1):423–32. Available from:


Haran-Ghera N, Krauthgamer R, Peled A. Malignant cell arrest in thymus and spleen of mice bearing transplanted tumors. Journal of Immunology [Internet]. 1981;126(4):1241–4. Available from:


Geltner D, Peled A. Absorption of serum antinuclear antibodies. Clinical Immunology and Immunopathology [Internet]. 1979;13(3):237–45. Available from:


Haran-Ghera N, Peled A. Induction of leukemia in mice by irradiation and radiation leukemia virus variants. Advances in Cancer Research [Internet]. 1979;30(C):45–87. Available from:


Peled A, Ben-Yaakov M, Brami S. The effect of lymphoreticular neoplasms on the age dependent increase of antinuclear antibodies. Journal of Clinical and Laboratory Immunology [Internet]. 1979;2(3):255–60. Available from:


Peled A, Haran-ghera N. Lack of transformation of murine thymocytes by thymic epithelium [24]. Nature [Internet]. 1978;274(5668):266–9. Available from:


Peled A. Cellular immune response induced by the radiation leukemia virus (RadLV). Leukemia Research [Internet]. 1977;1(4):333–43. Available from:


Haran Ghera N, Ben Yaakov M, Peled A. Immunologic characteristics in relation to high and low leukemogenic activity of radiation leukemia virus variants. I. Cellular analysis of immunosuppression. Journal of Immunology [Internet]. 1977;118(2):600–6. Available from:


Haran Ghera N, Ben Yaakov M, Chazan R, Peled A. Pathways in thymus and bone marrow derived lymphatic leukemia in mice. Bibliotheca Haematologica [Internet]. 1975;no.40:133–41. Available from:


Peled A, Berke G. Proceedings: Cell-mediated anti-leukemic cell immunity in C57BL/6 mice injected with the radiation leukemic virus. Israel Journal of Medical Sciences [Internet]. 1975;11(12):1396. Available from:


Peled A, Haran Ghera N. The cellular basis of immunosuppression caused by the radiation leukaemia virus. Immunology [Internet]. 1974;26(2):323–9. Available from:


Haran-Ghera N, Peled A. Thymus and bone marrow derived lymphatic leukaemia in mice [7]. Nature [Internet]. 1973;241(5389):396–8. Available from:


Haran-Ghera N, Ben-Yaakov M, Peled A, Bentwich Z. Immune status of sjl/j mice in relation to age and spontaneous tumor development. Journal of the National Cancer Institute [Internet]. 1973;50(5):1227–35. Available from:


Peled A, Haran-Ghera N. Immunological studies on the radiation leukaemia virus in C57BL mice. Nature New Biology [Internet]. 1971;232(34):244–5. Available from:


Peled A, Haran‐Ghera N. Immunosuppression by the radiation leukemia virus and its relation to lymphatic leukemia development. International Journal of Cancer [Internet]. 1971;8(1):97–106. Available from:


Haran-Ghera N, Peled A. The mechanism of radiation action in leukemogenesis. IV. Immune impairment as a coleukemogenic factor. Israel Journal of Medical Sciences [Internet]. 1968;4(6):1181–7. Available from:


Haran-Ghera N, Peled A. The mechanism of radiation action in leukaemogenesis. Isolation of a leukaemogenic filtrable agent from tissues of irradiated and normal c57bl mice. British Journal of Cancer [Internet]. 1967;21(4):730. Available from: