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Hadassah Medical Center - Gene Therapy: Axelrod Jonathan


Last updated February 2023 - Gene Therapy

List of Publications

(1) Rosenberg N, Van Haele M, Lanton T, Brashi N, Bromberg Z, Adler H, et al. Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling. J Hepatol 2022;77(6):1631-1641.

(2) Paldor M, Levkovitch-Siany O, Eidelshtein D, Adar R, Enk CD, Marmary Y, et al. Single-cell transcriptomics reveals a senescence-associated IL-6/CCR6 axis driving radiodermatitis. EMBO Mol Med 2022;14(8).

(3) Shriki A, Lanton T, Sonnenblick A, Levkovitch-Siany O, Eidelshtein D, Abramovitch R, et al. Multiple roles of il6 in hepatic injury, steatosis, and senescence aggregate to suppress tumorigenesis. Cancer Res 2021;81(18):4766-4777.

(4) Zuaiter M, Axelrod JH, Pizov G, Gofrit ON. Hyper-Interleukin-6 Protects Against Renal Ischemic-Reperfusion Injury—A Mouse Model. Front Surg 2021;8.

(5) Gamaev L, Mizrahi L, Friehmann T, Rosenberg N, Pappo O, Olam D, et al. The pro-oncogenic effect of the lncRNA H19 in the development of chronic inflammation-mediated hepatocellular carcinoma. Oncogene 2021;40(1):127-139.

(6) Grand M, Waqasi M, Demarta-Gatsi C, Wei Y, Peronet R, Commere P-, et al. Hepatic Inflammation Confers Protective Immunity Against Liver Stages of Malaria Parasite. Front Immunol 2020;11.

(7) Chai C, Cox B, Yaish D, Gross D, Rosenberg N, Amblard F, et al. Agonist of RORA Attenuates Nonalcoholic Fatty Liver Progression in Mice via Up-regulation of MicroRNA 122. Gastroenterology 2020;159(3):999-1014.e9.

(8) Khatib A, Solaimuthu B, Yosef MB, Rmaileh AA, Tanna M, Oren G, et al. The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype. Proc Natl Acad Sci U S A 2020;117(35):21420-21431.

(9) Durlacher-Betzer K, Hassan A, Levi R, Axelrod J, Silver J, Naveh-Many T. Interleukin-6 contributes to the increase in fibroblast growth factor 23 expression in acute and chronic kidney disease. Kidney Int 2018;94(2):315-325.

(10) Moll JM, Wehmöller M, Frank NC, Homey L, Baran P, Garbers C, et al. Split2 Protein-Ligation Generates Active IL-6-Type Hyper-Cytokines from Inactive Precursors. ACS Synth Biol 2017;6(12):2260-2272.

(11) Kleinschmidt D, Giannou AD, McGee HM, Kempski J, Steglich B, Huber FJ, et al. A protective function of IL-22BP in ischemia reperfusion and acetaminophen-induced liver injury. J Immunol 2017;199(12):4078-4090.

(12) Lanton T, Shriki A, Nechemia-Arbely Y, Abramovitch R, Levkovitch O, Adar R, et al. Interleukin 6–dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis. Hepatology 2017;65(5):1600-1611.

(13) Marmary Y, Adar R, Gaska S, Wygoda A, Maly A, Cohen J, et al. Radiation-induced loss of salivary gland function is driven by cellular senescence and prevented by IL6 modulation. Cancer Res 2016;76(5):1170-1180.

(14) Zahavi T, Lanton T, Divon MS, Salmon A, Peretz T, Galun E, et al. Sorafenib treatment during partial hepatectomy reduces tumorgenesis in an inflammation-associated liver cancer model. Oncotarget 2016;7(4):4860-4870.

(15) Khamaisi M, Toukan H, Axelrod JH, Rosenberger C, Skarzinski G, Shina A, et al. Endothelin-converting enzyme is a plausible target gene for hypoxia-inducible factor. Kidney Int 2015;87(4):761-770.

(16) Milman Z, Axelrod JH, Heyman SN, Nachmansson N, Abramovitch R. Assessment with unenhanced MRI techniques of renal morphology and hemodynamic changes during acute kidney injury and chronic kidney disease in mice. Am J Nephrol 2014;39(3):268-278.

(17) Abu-Tair L, Axelrod JH, Doron S, Ovadya Y, Krizhanovsky V, Galun E, et al. Natural killer cell-dependent anti-fibrotic pathway in liver injury via toll-like receptor-9. PLoS ONE 2013;8(12).

(18) Barashi N, Weiss ID, Wald O, Wald H, Beider K, Abraham M, et al. Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice. Hepatology 2013;58(3):1021-1030.

(19) Milman Z, Heyman SN, Corchia N, Edrei Y, Axelrod JH, Rosenberger C, et al. Hemodynamic response magnetic resonance imaging: Application for renal hemodynamic characterization. Nephrol Dial Transplant 2013;28(5):1150-1156.

(20) Sonnenblick A, Uziely B, Nechushtan H, Kadouri L, Galun E, Axelrod JH, et al. Tumor STAT3 tyrosine phosphorylation status, as a predictor of benefit from adjuvant chemotherapy for breast cancer. Breast Cancer Res Treat 2013;138(2):407-413.

(21) Nechemia-Arbely Y, Khamaisi M, Rosenberger C, Koesters R, Shina A, Geva C, et al. In vivo evidence suggesting reciprocal renal hypoxia-inducible factor-1 upregulation and signal transducer and activator of transcription 3 activation in response to hypoxic and non-hypoxic stimuli. Clin Exp Pharmacol Physiol 2013;40(4):262-272.

(22) Sonnenblick A, Shriki A, Galun E, Axelrod JH, Daum H, Rottenberg Y, et al. Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis. Clin Transl Oncol 2012;14(3):232-236.

(23) Nechemia-Arbely Y, Shriki A, Denz U, Drucker C, Scheller J, Raub J, et al. Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation. J Hepatol 2011;54(5):922-929.

(24) Drenger B, Ostrovsky IA, Barak M, Nechemia-Arbely Y, Ziv E, Axelrod JH. Diabetes blockade of sevoflurane postconditioning is not restored by insulin in the rat heart: Phosphorylated signal transducer and activator of transcription 3- and phosphatidylinositol 3-kinase-mediated inhibition. Anesthesiology 2011;114(6):1364-1372.

(25) Nechemia-Arbely Y, Barkan D, Pizov G, Shriki A, Rose-John S, Galun E, et al. IL-6/IL-6R axis plays a critical role in acute kidney injury. J Am Soc Nephrol 2008;19(6):1106-1115.

(26) Arad U, Axelrod J, Ben-nun-Shaul O, Oppenheim A, Galun E. Hepatitis B virus enhances transduction of human hepatocytes by SV40-based vectors. J Hepatol 2004;40(3):520-526.

(27) Sonza S, Mutimer HP, O'Brien K, Ellery P, Howard JL, Axelrod JH, et al. Selectively reduced tat mRNA heralds the decline in productive human immunodeficiency virus type 1 infection in monocyte-derived macrophages. J Virol 2002;76(24):12611-12621.

(28) Galun E, Axelrod JH. The role of cytokines in liver failure and regeneration: Potential new molecular therapies. Biochim Biophys Acta Mol Cell Res 2002;1592(3):345-358.

(29) Hecht N, Pappo O, Shouval D, Rose-John S, Galun E, Axelrod JH. Hyper-IL-6 gene therapy reverses fulminant hepatic failure. Mol Ther 2001;3(5):683-687.

(30) Axelrod JH, Honigman A. A sensitive and versatile bioluminescence bioassay for HIV type 1 based on adenoviral vectors. AIDS Res Hum Retroviruses 1999;15(8):759-767.

(31) Baru M, Axelrod JH, Nur I. Liposome-encapsulated DNA-mediated gene transfer and synthesis of human factor IX in mice. Gene 1995;161(2):143-150.

(32) Roman M, Axelrod JH, Dai Y, Naviaux RK, Friedmann T, Verma IM. Circulating human or canine factor IX from retrovirally transduced primary myoblasts and established myoblast cell lines grafted into murine skeletal muscle. Somat Cell Mol Genet 1992;18(3):247-258.

(33) Scharfmann R, Axelrod JH, Verma IM. Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants. Proc Natl Acad Sci U S A 1991;88(11):4626-4630.

(34) Axelrod JH, Read MS, Brinkhous KM, Verma IM. Phenotypic correction of factor IX deficiency in skin fibroblasts of hemophilic dogs. Proc Natl Acad Sci U S A 1990;87(13):5173-5177.

(35) MISKIN R, AXELROD JH, GRIEP AE, LEE E, BELIN D, VASSALLI J‐, et al. Human and murine urokinase cDNAs linked to the murine αA‐crystallin promoter exhibit lens and non‐lens expression in transgenic mice. Eur J Biochem 1990;190(1):31-38.

(36) Axelrod JH, Reich R, Miskin R. Expression of human recombinant plasminogen activators enhances invasion and experimental metastasis of H-ras-transformed NIH 3T3 cells. Mol Cell Biol 1989;9(5):2133-2141.

(37) Rotem N, Axelrod JH, Miskin R. Induction of urokinase-type plasminogen activator by UV light in human fetal fibroblasts is mediated through a UV-induced secreted protein. Mol Cell Biol 1987;7(2):622-631.

(38) Rajput B, Degen SF, Reich E, Waller EK, Axelrod J, Eddy RL, et al. Chromosomal locations of human tissue plasminogen activator and urokinase genes. Science 1985;230(4726):672-674.