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Hadassah Medical Center - Gene Therapy: Axelrod Jonathan

researchers

Last updated September 2023 - Gene Therapy

List of Publications

1.

Rosenberg N, Van Haele M, Lanton T, Brashi N, Bromberg Z, Adler H, et al. Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling. Journal of Hepatology [Internet]. 2022;77(6):1631–41. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85139606967&doi=10.1016%252fj.jhep.2022.07.029&partnerID=40&md5=f489c281205d830dc0f0f24b27016c75

2.

Paldor M, Levkovitch-Siany O, Eidelshtein D, Adar R, Enk CD, Marmary Y, et al. Single-cell transcriptomics reveals a senescence-associated IL-6/CCR6 axis driving radiodermatitis. EMBO Molecular Medicine [Internet]. 2022;14(8). Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85133390135&doi=10.15252%252femmm.202115653&partnerID=40&md5=c6919b2ced1cb3afb1537030fb5bffa5

3.

Shriki A, Lanton T, Sonnenblick A, Levkovitch-Siany O, Eidelshtein D, Abramovitch R, et al. Multiple roles of il6 in hepatic injury, steatosis, and senescence aggregate to suppress tumorigenesis. Cancer Research [Internet]. 2021;81(18):4766–77. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114989627&doi=10.1158%252f0008-5472.CAN-21-0321&partnerID=40&md5=1c1a969991ac20520189327aea98bde2

4.

Zuaiter M, Axelrod JH, Pizov G, Gofrit ON. Hyper-Interleukin-6 Protects Against Renal Ischemic-Reperfusion Injury—A Mouse Model. Frontiers in Surgery [Internet]. 2021;8. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107050827&doi=10.3389%252ffsurg.2021.605675&partnerID=40&md5=e16536633c28377ebbfa0c2972346d19

5.

Gamaev L, Mizrahi L, Friehmann T, Rosenberg N, Pappo O, Olam D, et al. The pro-oncogenic effect of the lncRNA H19 in the development of chronic inflammation-mediated hepatocellular carcinoma. Oncogene [Internet]. 2021;40(1):127–39. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85093510378&doi=10.1038%252fs41388-020-01513-7&partnerID=40&md5=5c0a505331a8469fca8ef5b699f49bf8

6.

Grand M, Waqasi M, Demarta-Gatsi C, Wei Y, Peronet R, Commere PH, et al. Hepatic Inflammation Confers Protective Immunity Against Liver Stages of Malaria Parasite. Frontiers in Immunology [Internet]. 2020;11. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097240269&doi=10.3389%252ffimmu.2020.585502&partnerID=40&md5=fc7f70118f1fb79a74fdd99944d3b04a

7.

Chai C, Cox B, Yaish D, Gross D, Rosenberg N, Amblard F, et al. Agonist of RORA Attenuates Nonalcoholic Fatty Liver Progression in Mice via Up-regulation of MicroRNA 122. Gastroenterology [Internet]. 2020;159(3):999-1014.e9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090877754&doi=10.1053%252fj.gastro.2020.05.056&partnerID=40&md5=eb027460d3d6248584c9927ba888d755

8.

Khatib A, Solaimuthu B, Yosef MB, Rmaileh AA, Tanna M, Oren G, et al. The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2020;117(35):21420–31. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090508263&doi=10.1073%252fpnas.2010275117&partnerID=40&md5=023db829caf37a6652d07579abe7fec1

9.

Durlacher-Betzer K, Hassan A, Levi R, Axelrod J, Silver J, Naveh-Many T. Interleukin-6 contributes to the increase in fibroblast growth factor 23 expression in acute and chronic kidney disease. Kidney International [Internet]. 2018;94(2):315–25. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047762467&doi=10.1016%252fj.kint.2018.02.026&partnerID=40&md5=6f2e33102c9b4a1a7de7a9a21af3478e

10.

Moll JM, Wehmöller M, Frank NC, Homey L, Baran P, Garbers C, et al. Split2 Protein-Ligation Generates Active IL-6-Type Hyper-Cytokines from Inactive Precursors. ACS Synthetic Biology [Internet]. 2017;6(12):2260–72. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038632476&doi=10.1021%252facssynbio.7b00208&partnerID=40&md5=3374856732db5570c71dcae823b7e00f

11.

Kleinschmidt D, Giannou AD, McGee HM, Kempski J, Steglich B, Huber FJ, et al. A protective function of IL-22BP in ischemia reperfusion and acetaminophen-induced liver injury. Journal of Immunology [Internet]. 2017;199(12):4078–90. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038572939&doi=10.4049%252fjimmunol.1700587&partnerID=40&md5=cbade5ad32b7273313fe6eabc60033d7

12.

Lanton T, Shriki A, Nechemia-Arbely Y, Abramovitch R, Levkovitch O, Adar R, et al. Interleukin 6–dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis. Hepatology [Internet]. 2017;65(5):1600–11. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85016405625&doi=10.1002%252fhep.29004&partnerID=40&md5=a649f901e6d6357da10b4b921aa41934

13.

Marmary Y, Adar R, Gaska S, Wygoda A, Maly A, Cohen J, et al. Radiation-induced loss of salivary gland function is driven by cellular senescence and prevented by IL6 modulation. Cancer Research [Internet]. 2016;76(5):1170–80. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961721990&doi=10.1158%252f0008-5472.CAN-15-1671&partnerID=40&md5=fd4cf99040bdea9aecbf492ec1c15d50

14.

Zahavi T, Lanton T, Divon MS, Salmon A, Peretz T, Galun E, et al. Sorafenib treatment during partial hepatectomy reduces tumorgenesis in an inflammation-associated liver cancer model. Oncotarget [Internet]. 2016;7(4):4860–70. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84957989883&doi=10.18632%252foncotarget.6638&partnerID=40&md5=3a2ef4cc632b9b40fbae1a2ace132b6d

15.

Khamaisi M, Toukan H, Axelrod JH, Rosenberger C, Skarzinski G, Shina A, et al. Endothelin-converting enzyme is a plausible target gene for hypoxia-inducible factor. Kidney International [Internet]. 2015;87(4):761–70. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84926518100&doi=10.1038%252fki.2014.362&partnerID=40&md5=8f792b1a3b86debd18025e6dc70967df

16.

Milman Z, Axelrod JH, Heyman SN, Nachmansson N, Abramovitch R. Assessment with unenhanced MRI techniques of renal morphology and hemodynamic changes during acute kidney injury and chronic kidney disease in mice. American Journal of Nephrology [Internet]. 2014;39(3):268–78. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84896427048&doi=10.1159%252f000360093&partnerID=40&md5=19f1f704979056ddc956dbc61019bfe4

17.

Abu-Tair L, Axelrod JH, Doron S, Ovadya Y, Krizhanovsky V, Galun E, et al. Natural killer cell-dependent anti-fibrotic pathway in liver injury via toll-like receptor-9. PLoS ONE [Internet]. 2013;8(12). Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84892394789&doi=10.1371%252fjournal.pone.0082571&partnerID=40&md5=cff7d83412232ea39180d095b134767c

18.

Barashi N, Weiss ID, Wald O, Wald H, Beider K, Abraham M, et al. Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice. Hepatology [Internet]. 2013;58(3):1021–30. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84883238925&doi=10.1002%252fhep.26403&partnerID=40&md5=a8b94726dcd37d8387f2e9e14aed4c67

19.

Milman Z, Heyman SN, Corchia N, Edrei Y, Axelrod JH, Rosenberger C, et al. Hemodynamic response magnetic resonance imaging: Application for renal hemodynamic characterization. Nephrology Dialysis Transplantation [Internet]. 2013;28(5):1150–6. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84877951805&doi=10.1093%252fndt%252fgfs541&partnerID=40&md5=011daf3996c301cc1c91c47e156a69bf

20.

Sonnenblick A, Uziely B, Nechushtan H, Kadouri L, Galun E, Axelrod JH, et al. Tumor STAT3 tyrosine phosphorylation status, as a predictor of benefit from adjuvant chemotherapy for breast cancer. Breast Cancer Research and Treatment [Internet]. 2013;138(2):407–13. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84879414816&doi=10.1007%252fs10549-013-2453-x&partnerID=40&md5=9257c7e780a0965b52628509efc2e002

21.

Nechemia-Arbely Y, Khamaisi M, Rosenberger C, Koesters R, Shina A, Geva C, et al. In vivo evidence suggesting reciprocal renal hypoxia-inducible factor-1 upregulation and signal transducer and activator of transcription 3 activation in response to hypoxic and non-hypoxic stimuli. Clinical and Experimental Pharmacology and Physiology [Internet]. 2013;40(4):262–72. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84875645849&doi=10.1111%252f1440-1681.12064&partnerID=40&md5=9cdd9178ddc7dec9325e573f9cc1699c

22.

Sonnenblick A, Shriki A, Galun E, Axelrod JH, Daum H, Rottenberg Y, et al. Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis. Clinical and Translational Oncology [Internet]. 2012;14(3):232–6. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84860760469&doi=10.1007%252fs12094-012-0789-z&partnerID=40&md5=4bfbce22aab3661934e5d970c51d4f3f

23.

Nechemia-Arbely Y, Shriki A, Denz U, Drucker C, Scheller J, Raub J, et al. Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation. Journal of Hepatology [Internet]. 2011;54(5):922–9. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-79954895368&doi=10.1016%252fj.jhep.2010.08.017&partnerID=40&md5=5b8f180844ca078c3f86edf548c1a6b7

24.

Drenger B, Ostrovsky IA, Barak M, Nechemia-Arbely Y, Ziv E, Axelrod JH. Diabetes blockade of sevoflurane postconditioning is not restored by insulin in the rat heart: Phosphorylated signal transducer and activator of transcription 3- and phosphatidylinositol 3-kinase-mediated inhibition. Anesthesiology [Internet]. 2011;114(6):1364–72. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-79958108043&doi=10.1097%252fALN.0b013e31820efafd&partnerID=40&md5=eb9d1516a1145bdd1b1f29ecfefb8631

25.

Nechemia-Arbely Y, Barkan D, Pizov G, Shriki A, Rose-John S, Galun E, et al. IL-6/IL-6R axis plays a critical role in acute kidney injury. Journal of the American Society of Nephrology [Internet]. 2008;19(6):1106–15. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-48049096638&doi=10.1681%252fASN.2007070744&partnerID=40&md5=4ecb93119869bfa29467c19bf5513d64

26.

Arad U, Axelrod J, Ben-nun Shaul O, Oppenheim A, Galun E. Hepatitis B virus enhances transduction of human hepatocytes by SV40-based vectors. Journal of Hepatology [Internet]. 2004;40(3):520–6. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-1242269867&doi=10.1016%252fj.jhep.2003.11.028&partnerID=40&md5=eddd5342d124a624236d2e0a68f7f9ee

27.

Sonza S, Mutimer HP, O’Brien K, Ellery P, Howard JL, Axelrod JH, et al. Selectively reduced tat mRNA heralds the decline in productive human immunodeficiency virus type 1 infection in monocyte-derived macrophages. Journal of Virology [Internet]. 2002;76(24):12611–21. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036893346&doi=10.1128%252fJVI.76.24.12611-12621.2002&partnerID=40&md5=258d78df4c15c73bcff89c0c49378e2c

28.

Galun E, Axelrod JH. The role of cytokines in liver failure and regeneration: Potential new molecular therapies. Biochimica et Biophysica Acta - Molecular Cell Research [Internet]. 2002;1592(3):345–58. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037064538&doi=10.1016%2fS0167-4889%2802%2900326-9&partnerID=40&md5=54e07b50a4d2cbf61471df3a490179e9

29.

Hecht N, Pappo O, Shouval D, Rose-John S, Galun E, Axelrod JH. Hyper-IL-6 gene therapy reverses fulminant hepatic failure. Molecular Therapy [Internet]. 2001;3(5):683–7. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034985726&doi=10.1006%252fmthe.2001.0313&partnerID=40&md5=42debe8a633491ff007fc37712c90ac7

30.

Axelrod JH, Honigman A. A sensitive and versatile bioluminescence bioassay for HIV type 1 based on adenoviral vectors. AIDS Research and Human Retroviruses [Internet]. 1999;15(8):759–67. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033586983&doi=10.1089%252f088922299310845&partnerID=40&md5=acc64b38ddba6644c4fc254a11bccd71

31.

Baru M, Axelrod JH, Nur I. Liposome-encapsulated DNA-mediated gene transfer and synthesis of human factor IX in mice. Gene [Internet]. 1995;161(2):143–50. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029166862&doi=10.1016%2f0378-1119%2895%2900281-A&partnerID=40&md5=da25defadf9dcaca430742789d3be07e

32.

Roman M, Axelrod JH, Dai Y, Naviaux RK, Friedmann T, Verma IM. Circulating human or canine factor IX from retrovirally transduced primary myoblasts and established myoblast cell lines grafted into murine skeletal muscle. Somatic Cell and Molecular Genetics [Internet]. 1992;18(3):247–58. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026730993&doi=10.1007%252fBF01233861&partnerID=40&md5=738d33db26094af8f47e5e17f98b4266

33.

Scharfmann R, Axelrod JH, Verma IM. Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 1991;88(11):4626–30. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025753128&doi=10.1073%252fpnas.88.11.4626&partnerID=40&md5=e833ef235989566c25db18234e8dde60

34.

Axelrod JH, Read MS, Brinkhous KM, Verma IM. Phenotypic correction of factor IX deficiency in skin fibroblasts of hemophilic dogs. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 1990;87(13):5173–7. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025374283&doi=10.1073%252fpnas.87.13.5173&partnerID=40&md5=2ebe75e2d3438ba16b3ae8a49fb540af

35.

MISKIN R, AXELROD JH, GRIEP AE, LEE E, BELIN D, VASSALLI J ‐D., et al. Human and murine urokinase cDNAs linked to the murine αA‐crystallin promoter exhibit lens and non‐lens expression in transgenic mice. European Journal of Biochemistry [Internet]. 1990;190(1):31–8. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025297143&doi=10.1111%252fj.1432-1033.1990.tb15541.x&partnerID=40&md5=e3d0962a9eaf96f47441f9f3cd5ece75

36.

Axelrod JH, Reich R, Miskin R. Expression of human recombinant plasminogen activators enhances invasion and experimental metastasis of H-ras-transformed NIH 3T3 cells. Molecular and Cellular Biology [Internet]. 1989;9(5):2133–41. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024556819&doi=10.1128%252fMCB.9.5.2133&partnerID=40&md5=75b81738400237f6259462c92aa38f8b

37.

Rotem N, Axelrod JH, Miskin R. Induction of urokinase-type plasminogen activator by UV light in human fetal fibroblasts is mediated through a UV-induced secreted protein. Molecular and Cellular Biology [Internet]. 1987;7(2):622–31. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023153938&doi=10.1128%252fMCB.7.2.622&partnerID=40&md5=d2933ca8a4f66f12bac15dd7fbaff3ab

38.

Rajput B, Degen SF, Reich E, Waller EK, Axelrod J, Eddy RL, et al. Chromosomal locations of human tissue plasminogen activator and urokinase genes. Science [Internet]. 1985;230(4726):672–4. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022367361&doi=10.1126%252fscience.3840278&partnerID=40&md5=97fcc2374a7cbfb3c96c81ff923f614f