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Hadassah Medical Center - Gene Therapy: Axelrod Jonathan


Last updated September 2023 - Gene Therapy

List of Publications


Rosenberg N, Van Haele M, Lanton T, Brashi N, Bromberg Z, Adler H, et al. Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling. Journal of Hepatology [Internet]. 2022;77(6):1631–41. Available from:


Paldor M, Levkovitch-Siany O, Eidelshtein D, Adar R, Enk CD, Marmary Y, et al. Single-cell transcriptomics reveals a senescence-associated IL-6/CCR6 axis driving radiodermatitis. EMBO Molecular Medicine [Internet]. 2022;14(8). Available from:


Shriki A, Lanton T, Sonnenblick A, Levkovitch-Siany O, Eidelshtein D, Abramovitch R, et al. Multiple roles of il6 in hepatic injury, steatosis, and senescence aggregate to suppress tumorigenesis. Cancer Research [Internet]. 2021;81(18):4766–77. Available from:


Zuaiter M, Axelrod JH, Pizov G, Gofrit ON. Hyper-Interleukin-6 Protects Against Renal Ischemic-Reperfusion Injury—A Mouse Model. Frontiers in Surgery [Internet]. 2021;8. Available from:


Gamaev L, Mizrahi L, Friehmann T, Rosenberg N, Pappo O, Olam D, et al. The pro-oncogenic effect of the lncRNA H19 in the development of chronic inflammation-mediated hepatocellular carcinoma. Oncogene [Internet]. 2021;40(1):127–39. Available from:


Grand M, Waqasi M, Demarta-Gatsi C, Wei Y, Peronet R, Commere PH, et al. Hepatic Inflammation Confers Protective Immunity Against Liver Stages of Malaria Parasite. Frontiers in Immunology [Internet]. 2020;11. Available from:


Chai C, Cox B, Yaish D, Gross D, Rosenberg N, Amblard F, et al. Agonist of RORA Attenuates Nonalcoholic Fatty Liver Progression in Mice via Up-regulation of MicroRNA 122. Gastroenterology [Internet]. 2020;159(3):999-1014.e9. Available from:


Khatib A, Solaimuthu B, Yosef MB, Rmaileh AA, Tanna M, Oren G, et al. The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2020;117(35):21420–31. Available from:


Durlacher-Betzer K, Hassan A, Levi R, Axelrod J, Silver J, Naveh-Many T. Interleukin-6 contributes to the increase in fibroblast growth factor 23 expression in acute and chronic kidney disease. Kidney International [Internet]. 2018;94(2):315–25. Available from:


Moll JM, Wehmöller M, Frank NC, Homey L, Baran P, Garbers C, et al. Split2 Protein-Ligation Generates Active IL-6-Type Hyper-Cytokines from Inactive Precursors. ACS Synthetic Biology [Internet]. 2017;6(12):2260–72. Available from:


Kleinschmidt D, Giannou AD, McGee HM, Kempski J, Steglich B, Huber FJ, et al. A protective function of IL-22BP in ischemia reperfusion and acetaminophen-induced liver injury. Journal of Immunology [Internet]. 2017;199(12):4078–90. Available from:


Lanton T, Shriki A, Nechemia-Arbely Y, Abramovitch R, Levkovitch O, Adar R, et al. Interleukin 6–dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis. Hepatology [Internet]. 2017;65(5):1600–11. Available from:


Marmary Y, Adar R, Gaska S, Wygoda A, Maly A, Cohen J, et al. Radiation-induced loss of salivary gland function is driven by cellular senescence and prevented by IL6 modulation. Cancer Research [Internet]. 2016;76(5):1170–80. Available from:


Zahavi T, Lanton T, Divon MS, Salmon A, Peretz T, Galun E, et al. Sorafenib treatment during partial hepatectomy reduces tumorgenesis in an inflammation-associated liver cancer model. Oncotarget [Internet]. 2016;7(4):4860–70. Available from:


Khamaisi M, Toukan H, Axelrod JH, Rosenberger C, Skarzinski G, Shina A, et al. Endothelin-converting enzyme is a plausible target gene for hypoxia-inducible factor. Kidney International [Internet]. 2015;87(4):761–70. Available from:


Milman Z, Axelrod JH, Heyman SN, Nachmansson N, Abramovitch R. Assessment with unenhanced MRI techniques of renal morphology and hemodynamic changes during acute kidney injury and chronic kidney disease in mice. American Journal of Nephrology [Internet]. 2014;39(3):268–78. Available from:


Abu-Tair L, Axelrod JH, Doron S, Ovadya Y, Krizhanovsky V, Galun E, et al. Natural killer cell-dependent anti-fibrotic pathway in liver injury via toll-like receptor-9. PLoS ONE [Internet]. 2013;8(12). Available from:


Barashi N, Weiss ID, Wald O, Wald H, Beider K, Abraham M, et al. Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice. Hepatology [Internet]. 2013;58(3):1021–30. Available from:


Milman Z, Heyman SN, Corchia N, Edrei Y, Axelrod JH, Rosenberger C, et al. Hemodynamic response magnetic resonance imaging: Application for renal hemodynamic characterization. Nephrology Dialysis Transplantation [Internet]. 2013;28(5):1150–6. Available from:


Sonnenblick A, Uziely B, Nechushtan H, Kadouri L, Galun E, Axelrod JH, et al. Tumor STAT3 tyrosine phosphorylation status, as a predictor of benefit from adjuvant chemotherapy for breast cancer. Breast Cancer Research and Treatment [Internet]. 2013;138(2):407–13. Available from:


Nechemia-Arbely Y, Khamaisi M, Rosenberger C, Koesters R, Shina A, Geva C, et al. In vivo evidence suggesting reciprocal renal hypoxia-inducible factor-1 upregulation and signal transducer and activator of transcription 3 activation in response to hypoxic and non-hypoxic stimuli. Clinical and Experimental Pharmacology and Physiology [Internet]. 2013;40(4):262–72. Available from:


Sonnenblick A, Shriki A, Galun E, Axelrod JH, Daum H, Rottenberg Y, et al. Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis. Clinical and Translational Oncology [Internet]. 2012;14(3):232–6. Available from:


Nechemia-Arbely Y, Shriki A, Denz U, Drucker C, Scheller J, Raub J, et al. Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation. Journal of Hepatology [Internet]. 2011;54(5):922–9. Available from:


Drenger B, Ostrovsky IA, Barak M, Nechemia-Arbely Y, Ziv E, Axelrod JH. Diabetes blockade of sevoflurane postconditioning is not restored by insulin in the rat heart: Phosphorylated signal transducer and activator of transcription 3- and phosphatidylinositol 3-kinase-mediated inhibition. Anesthesiology [Internet]. 2011;114(6):1364–72. Available from:


Nechemia-Arbely Y, Barkan D, Pizov G, Shriki A, Rose-John S, Galun E, et al. IL-6/IL-6R axis plays a critical role in acute kidney injury. Journal of the American Society of Nephrology [Internet]. 2008;19(6):1106–15. Available from:


Arad U, Axelrod J, Ben-nun Shaul O, Oppenheim A, Galun E. Hepatitis B virus enhances transduction of human hepatocytes by SV40-based vectors. Journal of Hepatology [Internet]. 2004;40(3):520–6. Available from:


Sonza S, Mutimer HP, O’Brien K, Ellery P, Howard JL, Axelrod JH, et al. Selectively reduced tat mRNA heralds the decline in productive human immunodeficiency virus type 1 infection in monocyte-derived macrophages. Journal of Virology [Internet]. 2002;76(24):12611–21. Available from:


Galun E, Axelrod JH. The role of cytokines in liver failure and regeneration: Potential new molecular therapies. Biochimica et Biophysica Acta - Molecular Cell Research [Internet]. 2002;1592(3):345–58. Available from:


Hecht N, Pappo O, Shouval D, Rose-John S, Galun E, Axelrod JH. Hyper-IL-6 gene therapy reverses fulminant hepatic failure. Molecular Therapy [Internet]. 2001;3(5):683–7. Available from:


Axelrod JH, Honigman A. A sensitive and versatile bioluminescence bioassay for HIV type 1 based on adenoviral vectors. AIDS Research and Human Retroviruses [Internet]. 1999;15(8):759–67. Available from:


Baru M, Axelrod JH, Nur I. Liposome-encapsulated DNA-mediated gene transfer and synthesis of human factor IX in mice. Gene [Internet]. 1995;161(2):143–50. Available from:


Roman M, Axelrod JH, Dai Y, Naviaux RK, Friedmann T, Verma IM. Circulating human or canine factor IX from retrovirally transduced primary myoblasts and established myoblast cell lines grafted into murine skeletal muscle. Somatic Cell and Molecular Genetics [Internet]. 1992;18(3):247–58. Available from:


Scharfmann R, Axelrod JH, Verma IM. Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 1991;88(11):4626–30. Available from:


Axelrod JH, Read MS, Brinkhous KM, Verma IM. Phenotypic correction of factor IX deficiency in skin fibroblasts of hemophilic dogs. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 1990;87(13):5173–7. Available from:


MISKIN R, AXELROD JH, GRIEP AE, LEE E, BELIN D, VASSALLI J ‐D., et al. Human and murine urokinase cDNAs linked to the murine αA‐crystallin promoter exhibit lens and non‐lens expression in transgenic mice. European Journal of Biochemistry [Internet]. 1990;190(1):31–8. Available from:


Axelrod JH, Reich R, Miskin R. Expression of human recombinant plasminogen activators enhances invasion and experimental metastasis of H-ras-transformed NIH 3T3 cells. Molecular and Cellular Biology [Internet]. 1989;9(5):2133–41. Available from:


Rotem N, Axelrod JH, Miskin R. Induction of urokinase-type plasminogen activator by UV light in human fetal fibroblasts is mediated through a UV-induced secreted protein. Molecular and Cellular Biology [Internet]. 1987;7(2):622–31. Available from:


Rajput B, Degen SF, Reich E, Waller EK, Axelrod J, Eddy RL, et al. Chromosomal locations of human tissue plasminogen activator and urokinase genes. Science [Internet]. 1985;230(4726):672–4. Available from: