Last updated December 2025 - Gene Therapy
1. Lanton T, Eidelshtein D, Rachmilewitz J, et al. Blockade of Interleukin-6 Trans-signaling in the Presence of Certain Gut Microbiota Induces Mature-onset Obesity in Mice. Gastro Hep Adv. 2026;5(2). doi:10.1016/j.gastha.2025.100819
2. Rosenberg N, Van Haele M, Lanton T, et al. Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling. J Hepatol. 2022;77(6):1631-1641. doi:10.1016/j.jhep.2022.07.029
3. Paldor M, Levkovitch-Siany O, Eidelshtein D, et al. Single-cell transcriptomics reveals a senescence-associated IL-6/CCR6 axis driving radiodermatitis. EMBO Mol Med. 2022;14(8). doi:10.15252/emmm.202115653
4. Shriki A, Lanton T, Sonnenblick A, et al. Multiple roles of il6 in hepatic injury, steatosis, and senescence aggregate to suppress tumorigenesis. Cancer Res. 2021;81(18):4766-4777. doi:10.1158/0008-5472.CAN-21-0321
5. Zuaiter M, Axelrod JH, Pizov G, Gofrit ON. Hyper-Interleukin-6 Protects Against Renal Ischemic-Reperfusion Injury—A Mouse Model. Front Surg. 2021;8. doi:10.3389/fsurg.2021.605675
6. Gamaev L, Mizrahi L, Friehmann T, et al. The pro-oncogenic effect of the lncRNA H19 in the development of chronic inflammation-mediated hepatocellular carcinoma. Oncogene. 2021;40(1):127-139. doi:10.1038/s41388-020-01513-7
7. Grand M, Waqasi M, Demarta-Gatsi C, et al. Hepatic Inflammation Confers Protective Immunity Against Liver Stages of Malaria Parasite. Front Immunol. 2020;11. doi:10.3389/fimmu.2020.585502
8. Chai C, Cox B, Yaish D, et al. Agonist of RORA Attenuates Nonalcoholic Fatty Liver Progression in Mice via Up-regulation of MicroRNA 122. Gastroenterology. 2020;159(3):999-1014.e9. doi:10.1053/j.gastro.2020.05.056
9. Khatib A, Solaimuthu B, Yosef MB, et al. The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype. Proc Natl Acad Sci U S A. 2020;117(35):21420-21431. doi:10.1073/pnas.2010275117
10. Durlacher-Betzer K, Hassan A, Levi R, Axelrod JH, Silver J, Naveh-Many T. Interleukin-6 contributes to the increase in fibroblast growth factor 23 expression in acute and chronic kidney disease. Kidney Int. 2018;94(2):315-325. doi:10.1016/j.kint.2018.02.026
11. Moll JM, Wehmöller M, Frank NC, et al. Split2 Protein-Ligation Generates Active IL-6-Type Hyper-Cytokines from Inactive Precursors. ACS Synth Biol. 2017;6(12):2260-2272. doi:10.1021/acssynbio.7b00208
12. Kleinschmidt D, Giannou A, McGee HM, et al. A protective function of IL-22BP in ischemia reperfusion and acetaminophen-induced liver injury. J Immunol. 2017;199(12):4078-4090. doi:10.4049/jimmunol.1700587
13. Lanton T, Shriki A, Nechemia-Arbely Y, et al. Interleukin 6–dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis. Hepatology. 2017;65(5):1600-1611. doi:10.1002/hep.29004
14. Marmary Y, Adar R, Gaska S, et al. Radiation-induced loss of salivary gland function is driven by cellular senescence and prevented by IL6 modulation. Cancer Res. 2016;76(5):1170-1180. doi:10.1158/0008-5472.CAN-15-1671
15. Zahavi T, Lanton T, Salmon-Divon MS, et al. Sorafenib treatment during partial hepatectomy reduces tumorgenesis in an inflammation-associated liver cancer model. Oncotarget. 2016;7(4):4860-4870. doi:10.18632/oncotarget.6638
16. Khamaisi M, Toukan H, Axelrod JH, et al. Endothelin-converting enzyme is a plausible target gene for hypoxia-inducible factor. Kidney Int. 2015;87(4):761-770. doi:10.1038/ki.2014.362
17. Milman Z, Axelrod JH, Heyman SN, Nachmansson N, Abramovitch R. Assessment with unenhanced MRI techniques of renal morphology and hemodynamic changes during acute kidney injury and chronic kidney disease in mice. Am J Nephrol. 2014;39(3):268-278. doi:10.1159/000360093
18. Abu-Tair L, Axelrod JH, Doron S, et al. Natural killer cell-dependent anti-fibrotic pathway in liver injury via toll-like receptor-9. PLoS One. 2013;8(12). doi:10.1371/journal.pone.0082571
19. Barashi N, Weiss ID, Wald O, et al. Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice. Hepatology. 2013;58(3):1021-1030. doi:10.1002/hep.26403
20. Milman Z, Heyman SN, Corchia N, et al. Hemodynamic response magnetic resonance imaging: Application for renal hemodynamic characterization. Nephrol Dial Transplant. 2013;28(5):1150-1156. doi:10.1093/ndt/gfs541
21. Sonnenblick A, Uziely B, Nechushtan H, et al. Tumor STAT3 tyrosine phosphorylation status, as a predictor of benefit from adjuvant chemotherapy for breast cancer. Breast Cancer Res Treat. 2013;138(2):407-413. doi:10.1007/s10549-013-2453-x
22. Nechemia-Arbely Y, Khamaisi M, Rosenberger C, et al. In vivo evidence suggesting reciprocal renal hypoxia-inducible factor-1 upregulation and signal transducer and activator of transcription 3 activation in response to hypoxic and non-hypoxic stimuli. Clin Exp Pharmacol Physiol. 2013;40(4):262-272. doi:10.1111/1440-1681.12064
23. Sonnenblick A, Shriki A, Galun E, et al. Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis. Clin Transl Oncol. 2012;14(3):232-236. doi:10.1007/s12094-012-0789-z
24. Nechemia-Arbely Y, Shriki A, Denz U, et al. Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation. J Hepatol. 2011;54(5):922-929. doi:10.1016/j.jhep.2010.08.017
25. Drenger B, Ostrovsky IA, Barak M, Nechemia-Arbely Y, Ziv E, Axelrod JH. Diabetes blockade of sevoflurane postconditioning is not restored by insulin in the rat heart: Phosphorylated signal transducer and activator of transcription 3- and phosphatidylinositol 3-kinase-mediated inhibition. In: Anesthesiology. Vol 114. Lippincott Williams and Wilkins kathiest.clai@apta.org; 2011:1364-1372. doi:10.1097/ALN.0b013e31820efafd
26. Nechemia-Arbely Y, Barkan D, Pizov G, et al. IL-6/IL-6R axis plays a critical role in acute kidney injury. J Am Soc Nephrol. 2008;19(6):1106-1115. doi:10.1681/ASN.2007070744
27. Arad U, Axelrod JH, Ben-Nun-Shaul O, Oppenheim A, Galun E. Hepatitis B virus enhances transduction of human hepatocytes by SV40-based vectors. J Hepatol. 2004;40(3):520-526. doi:10.1016/j.jhep.2003.11.028
28. Sonza S, Mutimer HP, O’Brien K, et al. Selectively reduced tat mRNA heralds the decline in productive human immunodeficiency virus type 1 infection in monocyte-derived macrophages. J Virol. 2002;76(24):12611-12621. doi:10.1128/JVI.76.24.12611-12621.2002
29. Galun E, Axelrod JH. The role of cytokines in liver failure and regeneration: Potential new molecular therapies. Biochim Biophys Acta - Mol Cell Res. 2002;1592(3):345-358. doi:10.1016/S0167-4889(02)00326-9
30. Hecht N, Pappo O, Shouval D, Rose-John S, Galun E, Axelrod JH. Hyper-IL-6 gene therapy reverses fulminant hepatic failure. Mol Ther. 2001;3(5):683-687. doi:10.1006/mthe.2001.0313
31. Axelrod JH, Honigman A. A sensitive and versatile bioluminescence bioassay for HIV type 1 based on adenoviral vectors. AIDS Res Hum Retroviruses. 1999;15(8):759-767. doi:10.1089/088922299310845
32. Baru M, Axelrod JH, Nur I. Liposome-encapsulated DNA-mediated gene transfer and synthesis of human factor IX in mice. Gene. 1995;161(2):143-150. doi:10.1016/0378-1119(95)00281-A
33. Roman M, Axelrod JH, Dai Y, Naviaux RK, Friedmann T, Verma IM. Circulating human or canine factor IX from retrovirally transduced primary myoblasts and established myoblast cell lines grafted into murine skeletal muscle. Somat Cell Mol Genet. 1992;18(3):247-258. doi:10.1007/BF01233861
34. Scharfmann R, Axelrod JH, Verma IM. Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants. Proc Natl Acad Sci U S A. 1991;88(11):4626-4630. doi:10.1073/pnas.88.11.4626
35. Axelrod JH, Read MS, Brinkhous KM, Verma IM. Phenotypic correction of factor IX deficiency in skin fibroblasts of hemophilic dogs. Proc Natl Acad Sci U S A. 1990;87(13):5173-5177. https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025374283&partnerID=40&md5=465f19a7b7925f99a2e0495a3b8962a2
36. Miskin R, Axelrod JH, Griep AE, et al. Human and murine urokinase cDNAs linked to the murine αA‐crystallin promoter exhibit lens and non‐lens expression in transgenic mice. Eur J Biochem. 1990;190(1):31-38. doi:10.1111/j.1432-1033.1990.tb15541.x
37. Axelrod JH, Reich R, Miskin R. Expression of human recombinant plasminogen activators enhances invasion and experimental metastasis of H-ras-transformed NIH 3T3 cells. Mol Cell Biol. 1989;9(5):2133-2141. doi:10.1128/MCB.9.5.2133
38. Rotem N, Axelrod JH, Miskin R. Induction of urokinase-type plasminogen activator by UV light in human fetal fibroblasts is mediated through a UV-induced secreted protein. Mol Cell Biol. 1987;7(2):622-631. doi:10.1128/MCB.7.2.622
39. Rajput B, Degen SF, Reich E, et al. Chromosomal locations of human tissue plasminogen activator and urokinase genes. Science (80- ). 1985;230(4726):672-674. doi:10.1126/science.3840278