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Hadassah Medical Center - Gene Therapy: Rachmilewitz Jacob


Last updated September 2023 - Gene Therapy

List of Publications


Ghantous L, Volman Y, Hefez R, Wald O, Stern E, Friehmann T, et al. The DNA damage response pathway regulates the expression of the immune checkpoint CD47. Communications Biology [Internet]. 2023;6(1). Available from:


Volman Y, Hefetz R, Galun E, Rachmilewitz J. DNA damage alters EGFR signaling and reprograms cellular response via Mre-11. Scientific Reports [Internet]. 2022;12(1). Available from:


Guedj A, Volman Y, Geiger-Maor A, Bolik J, Schumacher N, Künzel S, et al. Gut microbiota shape “inflamm-ageing” cytokines and account for age-dependent decline in DNA damage repair. Gut [Internet]. 2020;69(6):1064–75. Available from:


Kirmayer D, Grin A, Gefter J, Friedman M, Rachmilewitz J, Mosheiff R, et al. Guided Bone Regeneration with Ammoniomethacrylate-Based Barrier Membranes in a Radial Defect Model. BioMed Research International [Internet]. 2020;2020. Available from:


Idelson M, Alper R, Obolensky A, Yachimovich-Cohen N, Rachmilewitz J, Ejzenberg A, et al. Immunological Properties of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells. Stem Cell Reports [Internet]. 2018;11(3):681–95. Available from:


Guedj A, Geiger-Maor A, Benyamini H, Nevo Y, Elgavish S, Galun E, et al. Correction: Early age decline in DNA repair capacity in the liver: In depth profile of differential gene expression [Aging (Albany NY), 8, 11, (2017) (3131-3141)] DOI: 10.18632/aging.101120. Aging [Internet]. 2017;9(6):1640. Available from:


Guedj A, Geiger-Maor A, Galun E, Amsalem H, Rachmilewitz J. Early age decline in DNA repair capacity in the liver: In depth profile of differential gene expression. Aging [Internet]. 2016;8(11):3131–46. Available from:


Geiger-Maor A, Guedj A, Even-Ram S, Smith Y, Galun E, Rachmilewitz J. Macrophages regulate the systemic response to DNA damage by a cell nonautonomous mechanism. Cancer Research [Internet]. 2015;75(13):2663–73. Available from:


Levi I, Amsalem H, Nissan A, Darash-Yahana M, Peretz T, Mandelboim O, et al. Characterization of tumor infiltrating Natural Killer cell subset. Oncotarget [Internet]. 2015;6(15):1–9. Available from:


Aronin A, Amsili S, Prigozhina TB, Tzdaka K, Rachmilewitz J, Shani N, et al. Fn14•Trail Effectively Inhibits Hepatocellular Carcinoma Growth. PLoS ONE [Internet]. 2013;8(10). Available from:


Toledano N, Gur-Wahnon D, Ben-Yehuda A, Rachmilewitz J. Novel CD47: SIRPα Dependent Mechanism for the Activation of STAT3 in Antigen-Presenting Cell. PLoS ONE [Internet]. 2013;8(9). Available from:


Geiger-Maor A, Levi I, Even-Ram S, Smith Y, Bowdish DM, Nussbaum G, et al. Cells exposed to sublethal oxidative stress selectively attract monocytes/macrophages via scavenger receptors and MyD88-mediated signaling. Journal of Immunology [Internet]. 2012;188(3):1234–44. Available from:


Ochanuna Z, Geiger-Maor A, Dembinsky-Vaknin A, Karussis D, Tykocinski ML, Rachmilewitz J. Inhibition of effector function but not T cell activation and increase in FoxP3 expression in T cells differentiated in the presence of PP14. PLoS ONE [Internet]. 2010;5(9):1–10. Available from:


Rachmilewitz J. Glycosylation: An intrinsic sign of “danger.” Self/Nonself - Immune Recognition and Signaling [Internet]. 2010;1(3):250–4. Available from:


Yachimovich-Cohen N, Even-Ram S, Shufaro Y, Rachmilewitz J, Reubinoff B. Human embryonic stem cells suppress T cell responses via arginase I-dependent mechanism. Journal of Immunology [Internet]. 2010;184(3):1300–8. Available from:


Orbach A, Rachmilewitz J, Shani N, Isenberg Y, Parnas M, Huang JH, et al. CD40·FasL and CTLA-4·FasL fusion proteins induce apoptosis in malignant cell lines by dual signaling. American Journal of Pathology [Internet]. 2010;177(6):3159–68. Available from:


Zorde-Khvalevsky E, Abramovitch R, Barash H, Spivak-Pohis I, Rivkin L, Rachmilewitz J, et al. Toll-like receptor 3 signaling attenuates liver regeneration. Hepatology [Internet]. 2009;50(1):198–206. Available from:


Gur-Wahnon D, Borovsky Z, Liebergall M, Rachmilewitz J. The induction of APC with a distinct tolerogenic phenotype via contact-dependent STAT3 activation. PLoS ONE [Internet]. 2009;4(8). Available from:


Grin A, Sasson Y, Beyth S, Mosheiff R, Rachmilewitz J, Friedman M. In vitro study of a novel polymeric mesenchymal stem-cell coated membrane. Journal of Drug Delivery Science and Technology [Internet]. 2009;19(4):241–6. Available from:


Rachmilewitz J. Serial triggering model. Advances in Experimental Medicine and Biology [Internet]. 2008;640:95–102. Available from:


Amsalem H, Gaiger A, Mizrahi S, Yagel S, Rachmilewitz J. Characterization of a lymphocyte subset displaying a unique regulatory activity in human decidua. International Immunology [Internet]. 2008;20(9):1147–54. Available from:


Orbach A, Rachmilewitz J, Parnas M, Huang JH, Tykocinski ML, Dranitzki-Elhalel M. CTLA-4·FasL induces early apoptosis of activated T cells by interfering with anti-apoptotic signals. Journal of Immunology [Internet]. 2007;179(11):7287–94. Available from:


Dranitzki-Elhalel M, Huang JH, Sasson M, Rachmilewitz J, Parnas M, Tykocinski ML. CD40·FasL inhibits human T cells: Evidence for an auto-inhibitory loop-back mechanism. International Immunology [Internet]. 2007;19(4):355–63. Available from:


Khvalevsky E, Rivkin L, Rachmilewitz J, Galun E, Giladi H. TLR3 signaling in a hepatoma cell line is skewed towards apoptosis. Journal of Cellular Biochemistry [Internet]. 2007;100(5):1301–12. Available from:


Gur-Wahnon D, Borovsky Z, Beyth S, Liebergall M, Rachmilewitz J. Contact-dependent induction of regulatory antigen-presenting cells by human mesenchymal stem cells is mediated via STAT3 signaling. Experimental Hematology [Internet]. 2007;35(3):426–33. Available from:


Ish-Shalom E, Gargir A, André S, Borovsky Z, Ochanuna Z, Gabius HJ, et al. α2,6-Sialylation promotes binding of placental protein 14 via its Ca2+-dependent lectin activity: Insights into differential effects on CD45RO and CD45RA T cells. Glycobiology [Internet]. 2006;16(3):173–83. Available from:


Dranitzki-Elhalel M, Huang JH, Rachmilewitz J, Pappo O, Parnas M, Schmidt W, et al. CTLA-4·FasL inhibits allogeneic responses in vivo. Cellular Immunology [Internet]. 2006;239(2):129–35. Available from:


Beyth S, Borovsky Z, Mevorach D, Liebergall M, Gazit Z, Aslan H, et al. Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood [Internet]. 2005;105(5):2214–9. Available from:


Mishan-Eisenberg G, Borovsky Z, Weber MC, Gazit R, Tykocinski ML, Rachmilewitz J. Differential regulation of Th1/Th2 cytokine responses by placental protein 14. Journal of Immunology [Internet]. 2004;173(9):5524–30. Available from:


Elhalel MD, Huang JH, Schmidt W, Rachmilewitz J, Tykocinski ML. CTLA-4 · FasL induces alloantigen-specific hyporesponsiveness. Journal of Immunology [Internet]. 2003;170(12):5842–50. Available from:


Rachmilewitz J, Borovsky Z, Riely GJ, Miller R, Tykocinski ML. Negative regulation of T cell activation by placental protein 14 is mediated by the tyrosine phosphatase receptor CD45. Journal of Biological Chemistry [Internet]. 2003;278(16):14059–65. Available from:


Yaniv E, Borovsky Z, Mishan-Eisenberg G, Rachmilewitz J. Placental protein 14 regulates selective B cell responses. Cellular Immunology [Internet]. 2003;222(2):156–63. Available from:


Rachmilewitz J, Lanzavecchia A. A temporal and spatial summation model for T-cell activation: Signal integration and antigen decoding. Trends in Immunology [Internet]. 2002;23(12):592–5. Available from:


Borovsky Z, Mishan-Eisenberg G, Yaniv E, Rachmilewitz J. Serial triggering of T cell receptors results in incremental accumulation of signaling intermediates. Journal of Biological Chemistry [Internet]. 2002;277(24):21529–36. Available from:


Rachmilewitz J, Borovsky Z, Mishan-Eisenberg G, Yaniv E, Riely GJ, Tykocinski ML. Focal localization of placental protein 14 toward sites of TCR engagement. Journal of Immunology [Internet]. 2002;168(6):2745–50. Available from:


Rachmilewitz J, Riely GJ, Huang JH, Chen A, Tykocinski ML. A rheostatic mechanism for T-cell inhibition based on elevation of activation thresholds. Blood [Internet]. 2001;98(13):3727–32. Available from:


Rachmilewitz J, Riely GJ, Tykocinski ML. Placental protein 14 functions as a direct T-cell inhibitor. Cellular Immunology [Internet]. 1999;191(1):26–33. Available from:


Rachmilewitz J, Tykocinski ML. Differential effects of chondroitin sulfates A and B on monocyte and B- cell activation: Evidence for B-cell activation via a CD44-dependent pathway. Blood [Internet]. 1998;92(1):223–9. Available from:


Rachmilewitz J, Tykocinski ML. Human PP14: A unique immunosuppressive protein that targets early events in T-cell activation. FASEB Journal [Internet]. 1998;12(5). Available from:


Rachmilewitz J, Elkin M, Looijenga LHJ, Verkerk AJMH, Gonik B, Lustig O, et al. Characterization of the imprinted IPW gene: Allelic expression in normal and tumorigenic human tissues. Oncogene [Internet]. 1996;13(8):1687–92. Available from:


Rachmilewitz J, Elkin M, Rosensaft J, Gelman-Kohan Z, Ariel I, Lustig O, et al. H19 expression and tumorigenicity of choriocarcinoma derived cell lines. Oncogene [Internet]. 1995;11(5):863–70. Available from:


Rachmilewitz J, Goshen R, Elkin M, Gonik B, Neaman Z, Giloh H, et al. The interaction between cytotrophoblasts and their derived tumor cells. Gynecologic Oncology [Internet]. 1995;57(3):356–65. Available from:


Lorberboum-Galski H, Yarkoni S, Nechushtan A, Rachmilewitz J, De Groot N, Hochberg A. ABL and BCR Genes are not imprinted in androgenetic and gynogenetic human tissues. Biochemical and Biophysical Research Communications [Internet]. 1994;204(2):621–7. Available from:


Ne’eman Z, Gonik B, Goshen R, Rachmilewitz J, Ariel I, Rosenmann E, et al. Ultrastructural characteristics of cytotrophoblast cells during stages of differentiation. JSUBMICROSCCYTOLPATHOL [Internet]. 1994;26(3):341–6. Available from:


de Groot N, Rachmilewitz J, Ariel I, Goshen R, Lustig O, Hochberg A. Genetic imprinting in human embryogenesis H19 and IGF2 gene expression. Placenta [Internet]. 1994;15:285–302. Available from:


Gonik B, Rachmilewitz J, Hochberg A, Goshen R, de Groot N, Gonik B, et al. Induction of Tumor Necrosis Factor and lnterleukin-6 cmRNA in Human Cytotrophoblast Cells Exposedc to Lipopolysaccharide. Infectious Diseases in Obstetrics and Gynecology [Internet]. 1994;2(1):3–9. Available from:


Voutilainen R, Ilvesmäki V, Ariel I, Rachmilewitz J, De-Groot N, Hochberg A. Parallel regulation of parentally imprinted H19 and insulin-like growth factor-II genes in cultured human fetal adrenal cells. Endocrinology [Internet]. 1994;134(5):2051–6. Available from:


Ariel I, Lustig O, Oyer CE, Elkin M, Gonik B, Rachmilewitz J, et al. Relaxation of Imprinting in Trophoblastic Disease. Gynecologic Oncology [Internet]. 1994;53(2):212–9. Available from:


Rachmilewitz J, Gonik B, Goshen R, Ariel I, Schneider T, Degroot N, et al. Use of a novel system for defining a gene imprinting region. Biochemical and Biophysical Research Communications [Internet]. 1993;196(2):659–64. Available from:


De Groot N, Goshen R, Rachmilewitz J, Gonik B, Ben‐Hur H, Hochberg A. Genomic imprinting and b‐chorionic gonadotropin. Prenatal Diagnosis [Internet]. 1993;13(12):1159–60. Available from:


Rachmilewitz J, Gonik B, Goshen R, Ariel I, Schneider T, Eldar-Geva T, et al. Intermediate cells during cytotrophoblast differentiation in vitro. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research [Internet]. 1993;4(5):395–402. Available from:


Goshen R, Rachmilewitz J, Schneider T, de‐Groot N, Ariel I, Palti Z, et al. The expression of the H‐19 and IGF‐2 genes during human embryogenesis and placental development. Molecular Reproduction and Development [Internet]. 1993;34(4):374–9. Available from:


Hochberg A, DeGroot N, Rachmilewitz J, Gonik B. Genetic imprinting in human evolution: The decisive role of maternal lineage. Medical Hypotheses [Internet]. 1993;41(4):355–7. Available from:


Eldar-Geva T, Rachmilewitz J, de Groot N, Hochberg A. Interaction between choriocarcinoma cell line (JAr) and human cytotrophoblasts in vitro. Placenta [Internet]. 1993;14(2):217–23. Available from:


Rachmilewitz J, Goshen R, Ariel I, Schneider T, de Groot N, Hochberg A. Parental imprinting of the human H19 gene. FEBS Letters [Internet]. 1992;309(1):25–8. Available from:


Rachmilewitz J, Gileadi O, Eldar‐Geva T, Schneider T, De‐Groot N, Hochberg A. Transcription of the H19 gene in differentiating cytotrophoblasts from human placenta. Molecular Reproduction and Development [Internet]. 1992;32(3):196–202. Available from:


Hochberg A, Rachmilewitz J, Eldar-Geva T, Salant T, Schneider T, de Groot N. Differentiation of Choriocarcinoma Cell Line (JAr). Cancer Research [Internet]. 1992;52(13):3713–7. Available from: