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Hadassah Medical Center - Gene Therapy: Rachmilewitz Jacob


Last updated December 2021 - Gene Therapy

List of Publications

(1) Guedj A, Volman Y, Geiger-Maor A, Bolik J, Schumacher N, Künzel S, et al. Gut microbiota shape 'inflamm-ageing' cytokines and account for age-dependent decline in DNA damage repair. Gut 2020;69(6):1064-1075.

(2) Kirmayer D, Grin A, Gefter J, Friedman M, Rachmilewitz J, Mosheiff R, et al. Guided Bone Regeneration with Ammoniomethacrylate-Based Barrier Membranes in a Radial Defect Model. BioMed Res Int 2020;2020.

(3) Idelson M, Alper R, Obolensky A, Yachimovich-Cohen N, Rachmilewitz J, Ejzenberg A, et al. Immunological Properties of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells. Stem Cell Rep 2018;11(3):681-695.

(4) Guedj A, Geiger-Maor A, Benyamini H, Nevo Y, Elgavish S, Galun E, et al. Correction: Early age decline in DNA repair capacity in the liver: In depth profile of differential gene expression [Aging (Albany NY), 8, 11, (2017) (3131-3141)] DOI: 10.18632/aging.101120. Aging 2017;9(6):1640.

(5) Guedj A, Geiger-Maor A, Galun E, Amsalem H, Rachmilewitz J. Early age decline in DNA repair capacity in the liver: In depth profile of differential gene expression. Aging 2016;8(11):3131-3146.

(6) Geiger-Maor A, Guedj A, Even-Ram S, Smith Y, Galun E, Rachmilewitz J. Macrophages regulate the systemic response to DNA damage by a cell nonautonomous mechanism. Cancer Res 2015;75(13):2663-2673.

(7) Levi I, Amsalem H, Nissan A, Darash-Yahana M, Peretz T, Mandelboim O, et al. Characterization of tumor infiltrating Natural Killer cell subset. Oncotarget 2015;6(15):1-9.

(8) Aronin A, Amsili S, Prigozhina TB, Tzdaka K, Rachmilewitz J, Shani N, et al. Fn14•Trail Effectively Inhibits Hepatocellular Carcinoma Growth. PLoS ONE 2013;8(10).

(9) Toledano N, Gur-Wahnon D, Ben-Yehuda A, Rachmilewitz J. Novel CD47: SIRPα Dependent Mechanism for the Activation of STAT3 in Antigen-Presenting Cell. PLoS ONE 2013;8(9).

(10) Geiger-Maor A, Levi I, Even-Ram S, Smith Y, Bowdish DM, Nussbaum G, et al. Cells exposed to sublethal oxidative stress selectively attract monocytes/macrophages via scavenger receptors and MyD88-mediated signaling. J Immunol 2012;188(3):1234-1244.

(11) Ochanuna Z, Geiger-Maor A, Dembinsky-Vaknin A, Karussis D, Tykocinski ML, Rachmilewitz J. Inhibition of effector function but not T cell activation and increase in FoxP3 expression in T cells differentiated in the presence of PP14. PLoS ONE 2010;5(9):1-10.

(12) Rachmilewitz J. Glycosylation: An intrinsic sign of "danger". Self/Nonself - Immune Recogn Signal 2010;1(3):250-254.

(13) Yachimovich-Cohen N, Even-Ram S, Shufaro Y, Rachmilewitz J, Reubinoff B. Human embryonic stem cells suppress T cell responses via arginase I-dependent mechanism. J Immunol 2010;184(3):1300-1308.

(14) Orbach A, Rachmilewitz J, Shani N, Isenberg Y, Parnas M, Huang J-, et al. CD40·FasL and CTLA-4·FasL fusion proteins induce apoptosis in malignant cell lines by dual signaling. Am J Pathol 2010;177(6):3159-3168.

(15) Zorde-Khvalevsky E, Abramovitch R, Barash H, Spivak-Pohis I, Rivkin L, Rachmilewitz J, et al. Toll-like receptor 3 signaling attenuates liver regeneration. Hepatology 2009;50(1):198-206.

(16) Gur-Wahnon D, Borovsky Z, Liebergall M, Rachmilewitz J. The induction of APC with a distinct tolerogenic phenotype via contact-dependent STAT3 activation. PLoS ONE 2009;4(8).

(17) Grin A, Sasson Y, Beyth S, Mosheiff R, Rachmilewitz J, Friedman M. In vitro study of a novel polymeric mesenchymal stem-cell coated membrane. J Drug Deliv Sci Technol 2009;19(4):241-246.

(18) Rachmilewitz J. Serial triggering model. Adv Exp Med Biol 2008;640:95-102.

(19) Amsalem H, Gaiger A, Mizrahi S, Yagel S, Rachmilewitz J. Characterization of a lymphocyte subset displaying a unique regulatory activity in human decidua. Int Immunol 2008;20(9):1147-1154.

(20) Orbach A, Rachmilewitz J, Parnas M, Huang J-, Tykocinski ML, Dranitzki-Elhalel M. CTLA-4·FasL induces early apoptosis of activated T cells by interfering with anti-apoptotic signals. J Immunol 2007;179(11):7287-7294.

(21) Dranitzki-Elhalel M, Huang JH, Sasson M, Rachmilewitz J, Parnas M, Tykocinski ML. CD40·FasL inhibits human T cells: Evidence for an auto-inhibitory loop-back mechanism. Int Immunol 2007;19(4):355-363.

(22) Khvalevsky E, Rivkin L, Rachmilewitz J, Galun E, Giladi H. TLR3 signaling in a hepatoma cell line is skewed towards apoptosis. J Cell Biochem 2007;100(5):1301-1312.

(23) Gur-Wahnon D, Borovsky Z, Beyth S, Liebergall M, Rachmilewitz J. Contact-dependent induction of regulatory antigen-presenting cells by human mesenchymal stem cells is mediated via STAT3 signaling. Exp Hematol 2007;35(3):426-433.

(24) Ish-Shalom E, Gargir A, André S, Borovsky Z, Ochanuna Z, Gabius H-, et al. α2,6-Sialylation promotes binding of placental protein 14 via its Ca2+-dependent lectin activity: Insights into differential effects on CD45RO and CD45RA T cells. Glycobiology 2006;16(3):173-183.

(25) Dranitzki-Elhalel M, Huang J-, Rachmilewitz J, Pappo O, Parnas M, Schmidt W, et al. CTLA-4·FasL inhibits allogeneic responses in vivo. Cell Immunol 2006;239(2):129-135.

(26) Beyth S, Borovsky Z, Mevorach D, Liebergall M, Gazit Z, Aslan H, et al. Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood 2005;105(5):2214-2219.

(27) Mishan-Eisenberg G, Borovsky Z, Weber MC, Gazit R, Tykocinski ML, Rachmilewitz J. Differential regulation of Th1/Th2 cytokine responses by placental protein 14. J Immunol 2004;173(9):5524-5530.

(28) Elhalel MD, Huang J-, Schmidt W, Rachmilewitz J, Tykocinski ML. CTLA-4 · FasL induces alloantigen-specific hyporesponsiveness. J Immunol 2003;170(12):5842-5850.

(29) Rachmilewitz J, Borovsky Z, Riely GJ, Miller R, Tykocinski ML. Negative regulation of T cell activation by placental protein 14 is mediated by the tyrosine phosphatase receptor CD45. J Biol Chem 2003;278(16):14059-14065.

(30) Yaniv E, Borovsky Z, Mishan-Eisenberg G, Rachmilewitz J. Placental protein 14 regulates selective B cell responses. Cell Immunol 2003;222(2):156-163.

(31) Rachmilewitz J, Lanzavecchia A. A temporal and spatial summation model for T-cell activation: Signal integration and antigen decoding. Trends Immunol 2002;23(12):592-595.

(32) Borovsky Z, Mishan-Eisenberg G, Yaniv E, Rachmilewitz J. Serial triggering of T cell receptors results in incremental accumulation of signaling intermediates. J Biol Chem 2002;277(24):21529-21536.

(33) Rachmilewitz J, Borovsky Z, Mishan-Eisenberg G, Yaniv E, Riely GJ, Tykocinski ML. Focal localization of placental protein 14 toward sites of TCR engagement. J Immunol 2002;168(6):2745-2750.

(34) Rachmilewitz J, Riely GJ, Huang J-, Chen A, Tykocinski ML. A rheostatic mechanism for T-cell inhibition based on elevation of activation thresholds. Blood 2001;98(13):3727-3732.

(35) Rachmilewitz J, Riely GJ, Tykocinski ML. Placental protein 14 functions as a direct T-cell inhibitor. Cell Immunol 1999;191(1):26-33.

(36) Rachmilewitz J, Tykocinski ML. Differential effects of chondroitin sulfates A and B on monocyte and B- cell activation: Evidence for B-cell activation via a CD44-dependent pathway. Blood 1998;92(1):223-229.

(37) Rachmilewitz J, Tykocinski ML. Human PP14: A unique immunosuppressive protein that targets early events in T-cell activation. FASEB J 1998;12(5).

(38) Rachmilewitz J, Elkin M, Looijenga LHJ, Verkerk AJMH, Gonik B, Lustig O, et al. Characterization of the imprinted IPW gene: Allelic expression in normal and tumorigenic human tissues. Oncogene 1996;13(8):1687-1692.

(39) Rachmilewitz J, Elkin M, Rosensaft J, Gelman-Kohan Z, Ariel I, Lustig O, et al. H19 expression and tumorigenicity of choriocarcinoma derived cell lines. Oncogene 1995;11(5):863-870.

(40) Rachmilewitz J, Goshen R, Elkin M, Gonik B, Neaman Z, Giloh H, et al. The interaction between cytotrophoblasts and their derived tumor cells. Gynecol Oncol 1995;57(3):356-365.

(41) Lorberboum-Galski H, Yarkoni S, Nechushtan A, Rachmilewitz J, De Groot N, Hochberg A. ABL and BCR Genes are not imprinted in androgenetic and gynogenetic human tissues. Biochem Biophys Res Commun 1994;204(2):621-627.

(42) Ne'eman Z, Gonik B, Goshen R, Rachmilewitz J, Ariel I, Rosenmann E, et al. Ultrastructural characteristics of cytotrophoblast cells during stages of differentiation. J Submicrosc Cytol Pathol 1994;26(3):341-346.

(43) de Groot N, Rachmilewitz J, Ariel I, Goshen R, Lustig O, Hochberg A. Genetic imprinting in human embryogenesis H19 and IGF2 gene expression. Placenta 1994;15:285-302.

(44) Gonik B, Rachmilewitz J, Hochberg A, Goshen R, de-Groot N, Gonik B, et al. Induction of Tumor Necrosis Factor and lnterleukin-6 cmRNA in Human Cytotrophoblast Cells Exposedc to Lipopolysaccharide. Infect Dis Obstet Gynecol 1994;2(1):3-9.

(45) Voutilainen R, Ilvesmäki V, Ariel I, Rachmilewitz J, De-Groot N, Hochberg A. Parallel regulation of parentally imprinted H19 and insulin-like growth factor-II genes in cultured human fetal adrenal cells. Endocrinology 1994;134(5):2051-2056.

(46) Ariel I, Lustig O, Oyer CE, Elkin M, Gonik B, Rachmilewitz J, et al. Relaxation of Imprinting in Trophoblastic Disease. Gynecol Oncol 1994;53(2):212-219.

(47) Rachmilewitz J, Gonik B, Goshen R, Ariel I, Schneider T, Degroot N, et al. Use of a novel system for defining a gene imprinting region. Biochem Biophys Res Commun 1993;196(2):659-664.

(48) De Groot N, Goshen R, Rachmilewitz J, Gonik B, Ben‐Hur H, Hochberg A. Genomic imprinting and b‐chorionic gonadotropin. Prenat Diagn 1993;13(12):1159-1160.

(49) Rachmilewitz J, Gonik B, Goshen R, Ariel I, Schneider T, Eldar-Geva T, et al. Intermediate cells during cytotrophoblast differentiation in vitro. Cell Growth Differ 1993;4(5):395-402.

(50) Goshen R, Rachmilewitz J, Schneider T, de‐Groot N, Ariel I, Palti Z, et al. The expression of the H‐19 and IGF‐2 genes during human embryogenesis and placental development. Mol Reprod Dev 1993;34(4):374-379.

(51) Hochberg A, DeGroot N, Rachmilewitz J, Gonik B. Genetic imprinting in human evolution: The decisive role of maternal lineage. Med Hypotheses 1993;41(4):355-357.

(52) Eldar-Geva T, Rachmilewitz J, de Groot N, Hochberg A. Interaction between choriocarcinoma cell line (JAr) and human cytotrophoblasts in vitro. Placenta 1993;14(2):217-223.

(53) Rachmilewitz J, Goshen R, Ariel I, Schneider T, de Groot N, Hochberg A. Parental imprinting of the human H19 gene. FEBS Lett 1992;309(1):25-28.

(54) Rachmilewitz J, Gileadi O, Eldar‐Geva T, Schneider T, De‐Groot N, Hochberg A. Transcription of the H19 gene in differentiating cytotrophoblasts from human placenta. Mol Reprod Dev 1992;32(3):196-202.

(55) Hochberg A, Rachmilewitz J, Eldar-Geva T, Salant T, Schneider T, de Groot N. Differentiation of Choriocarcinoma Cell Line (JAr). Cancer Res 1992;52(13):3713-3717.