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The Faculty of Medicine - Biochemistry and Molecular Biology: Barenholz Chezy


 Last updated September 2023 - Biochemistry and Molecular Biology 

List of Publications


Szebeni J, Kiss B, Bozó T, Turjeman K, Levi-Kalisman Y, Barenholz Y, et al. Insights into the Structure of Comirnaty Covid-19 Vaccine: A Theory on Soft, Partially Bilayer-Covered Nanoparticles with Hydrogen Bond-Stabilized mRNA-Lipid Complexes. ACS Nano [Internet]. 2023;17(14):13147–57. Available from:


Chen WA, Chang DY, Chen BM, Lin YC, Barenholz Y, Roffler SR. Antibodies against Poly(ethylene glycol) Activate Innate Immune Cells and Induce Hypersensitivity Reactions to PEGylated Nanomedicines. ACS Nano [Internet]. 2023;17(6):5757–72. Available from:


Bavli Y, Chen BM, Gross G, Hershko A, Turjeman K, Roffler S, et al. Anti-PEG antibodies before and after a first dose of Comirnaty® (mRNA-LNP-based SARS-CoV-2 vaccine). Journal of Controlled Release [Internet]. 2023;354:316–22. Available from:


Shilo-Benjamini Y, Lavy E, Yair N, Milgram J, Zilbersheid D, Hod A, et al. Therapeutic efficacy and pharmacokinetics of liposomal-cannabidiol injection: a pilot clinical study in dogs with naturally-occurring osteoarthritis. Frontiers in Veterinary Science [Internet]. 2023;10. Available from:


Pinto N, Klein Y, David E, Polak D, Steinberg D, Mizrahi G, et al. Resolvin D1 improves allograft osteointegration and directly enhances osteoblasts differentiation. Frontiers in Immunology [Internet]. 2023;14. Available from:


Klein Y, Levin-Talmor O, Berkstein JG, Wald S, Meirow Y, Maimon A, et al. Resolvin D1 shows osseous-protection via RANK reduction on monocytes during orthodontic tooth movement. Frontiers in Immunology [Internet]. 2022;13. Available from:


Shilo-Benjamini Y, Cern A, Zilbersheid D, Hod A, Lavy E, Barasch D, et al. A Case Report of Subcutaneously Injected Liposomal Cannabidiol Formulation Used as a Compassion Therapy for Pain Management in a Dog. Frontiers in Veterinary Science [Internet]. 2022;9. Available from:


Saragovi A, Zilberman T, Yasur G, Turjeman K, Abramovich I, Kuchersky M, et al. Analysis of cellular water content in T cells reveals a switch from slow metabolic water gain to rapid water influx prior to cell division. Journal of Biological Chemistry [Internet]. 2022;298(4). Available from:


Szebeni J, Storm G, Ljubimova JY, Castells M, Phillips EJ, Turjeman K, et al. Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines. Nature Nanotechnology [Internet]. 2022;17(4):337–46. Available from:


Chaushu S, Klein Y, Mandelboim O, Barenholz Y, Fleissig O. Immune Changes Induced by Orthodontic Forces: A Critical Review. Journal of Dental Research [Internet]. 2022;101(1):11–20. Available from:


Cern A, Bavli Y, Hod A, Zilbersheid D, Mushtaq S, Michael-Gayego A, et al. Therapeutic potential of injectable nano-mupirocin liposomes for infections involving multidrug-resistant bacteria. Pharmaceutics [Internet]. 2021;13(12). Available from:


Portnoy EG, Andriyanov AV, Han H, Eyal S, Barenholz Y. Pegylated liposomes remotely loaded with the combination of doxorubicin, quinine, and indocyanine green enable successful treatment of multidrug-resistant tumors. Pharmaceutics [Internet]. 2021;13(12). Available from:


Goldstein Y, Spitz S, Turjeman K, Selinger F, Barenholz Y, Ertl P, et al. Breaking the third wall: Implementing 3d-printing technics to expand the complexity and abilities of multi-organ-on-a-chip devices. Micromachines [Internet]. 2021;12(6). Available from:


Schilt Y, Berman T, Wei X, Nativ-Roth E, Barenholz Y, Raviv U. Effect of the ammonium salt anion on the structure of doxorubicin complex and PEGylated liposomal doxorubicin nanodrugs. Biochimica et Biophysica Acta - General Subjects [Internet]. 2021;1865(5). Available from:


Szebeni J, Barenholz YC. Complement Activation, Immunogenicity, and Immune Suppression as Potential Side Effects of Liposomes [Internet]. Advances in Clinical Immunology, Medical Microbiology, COVID-19, and Big Data. 2021. Available from:


Bavli Y, Rabie M, Fellig Y, Nevo Y, Barenholz Y. Liposomal bupivacaine (Bupigel) demonstrates minimal local nerve toxicity in a rabbit functional model. Pharmaceutics [Internet]. 2021;13(2):1–17. Available from:


Nordström R, Zhu L, Härmark J, Levi-Kalisman Y, Koren E, Barenholz Y, et al. Quantitative cryo-tem reveals new structural details of doxil-like pegylated liposomal doxorubicin formulation. Pharmaceutics [Internet]. 2021;13(1):1–19. Available from:


Klein Y, Fleissig O, Polak D, Barenholz Y, Mandelboim O, Chaushu S. Immunorthodontics: in vivo gene expression of orthodontic tooth movement. Scientific Reports [Internet]. 2020;10(1). Available from:


Chen E, Chen BM, Su YC, Chang YC, Cheng TL, Barenholz Y, et al. Premature Drug Release from Polyethylene Glycol (PEG)-Coated Liposomal Doxorubicin via Formation of the Membrane Attack Complex. ACS Nano [Internet]. 2020;14(7):7808–22. Available from:


Bavli Y, Chen BM, Roffler SR, Dobrovolskaia MA, Elnekave E, Ash S, et al. PEGylated Liposomal Methyl Prednisolone Succinate does not Induce Infusion Reactions in Patients: A correlation between in vitro immunological and in vivo clinical studies. Molecules [Internet]. 2020;25(3). Available from:


Singh MS, Goldsmith M, Thakur K, Chatterjee S, Landesman-Milo D, Levy T, et al. An ovarian spheroid based tumor model that represents vascularized tumors and enables the investigation of nanomedicine therapeutics. Nanoscale [Internet]. 2020;12(3):1894–903. Available from:


Silverman L, Barenholz Y. Effect of major tumor metabolites on the release of doxorubicin from Doxil – implications for precision nanomedicine. Precision Nanomedicine [Internet]. 2020;3(4):699–708. Available from:


Even-Or O, Avniel-Polak S, Barenholz Y, Nussbaum G. The cationic liposome CCS/C adjuvant induces immunity to influenza independently of the adaptor protein MyD88. Human Vaccines and Immunotherapeutics [Internet]. 2020;16(12):3146–54. Available from:


Gawne PJ, Clarke F, Turjeman K, Cope AP, Long NJ, Barenholz Y, et al. PET imaging of liposomal glucocorticoids using 89Zr-oxine: Theranostic applications in inflammatory arthritis. Theranostics [Internet]. 2020;10(9):3867–79. Available from:


Goldmann O, Cern A, Muesken M, Rohde M, Weiss W, Barenholz Y, et al. Liposomal mupirocin holds promise for systemic treatment of invasive Staphylococcus aureus infections. Journal of Controlled Release [Internet]. 2019;316:292–301. Available from:


Shaltiel L, Shemesh A, Raviv U, Barenholz Y, Levi-Kalisman Y. Synthesis and Characterization of Thiolate-Protected Gold Nanoparticles of Controlled Diameter. Journal of Physical Chemistry C [Internet]. 2019;123(46):28486–93. Available from:


Kozma GT, Mészáros T, Vashegyi I, Fülöp T, Örfi E, Dézsi L, et al. Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions. ACS Nano [Internet]. 2019;13(8):9315–24. Available from:


Bavli Y, Winkler I, Chen BM, Roffler S, Cohen R, Szebeni J, et al. Doxebo (doxorubicin-free Doxil-like liposomes) is safe to use as a pre-treatment to prevent infusion reactions to PEGylated nanodrugs. Journal of Controlled Release [Internet]. 2019;306:138–48. Available from:


Abdelrehim A, Shaltiel L, Zhang L, Barenholz Y, High S, Harris LK. The use of tail-anchored protein chimeras to enhance liposomal cargo delivery. PLoS ONE [Internet]. 2019;14(2). Available from:


Turjeman K, Yanay N, Elbaz M, Bavli Y, Gross M, Rabie M, et al. Liposomal steroid nano-drug is superior to steroids as-is in mdx mouse model of Duchenne muscular dystrophy. Nanomedicine: Nanotechnology, Biology, and Medicine [Internet]. 2019;16:34–44. Available from:


Szebeni J, Simberg D, González-Fernández Á, Barenholz Y, Dobrovolskaia MA. Roadmap and strategy for overcoming infusion reactions to nanomedicines. Nature Nanotechnology [Internet]. 2018;13(12):1100–8. Available from:


Peretz Damari S, Shamrakov D, Varenik M, Koren E, Nativ-Roth E, Barenholz Y, et al. Practical aspects in size and morphology characterization of drug-loaded nano-liposomes. International Journal of Pharmaceutics [Internet]. 2018;547(1–2):648–55. Available from:


Cern A, Connolly KL, Jerse AE, Barenholz Y. In vitro susceptibility of neisseria gonorrhoeae strains to mupirocin, an antibiotic reformulated for parenteral administration in nanoliposomes. Antimicrobial Agents and Chemotherapy [Internet]. 2018;62(4). Available from:


Wei X, Shamrakov D, Nudelman S, Peretz-Damari S, Nativ-Roth E, Regev O, et al. Cardinal Role of Intraliposome Doxorubicin-Sulfate Nanorod Crystal in Doxil Properties and Performance. ACS Omega [Internet]. 2018;3(3):2508–17. Available from:


Neun BW, Barenholz Y, Szebeni J, Dobrovolskaia MA. Understanding the role of anti-PEG antibodies in the complement activation by Doxil in vitro. Molecules [Internet]. 2018;23(7). Available from:


Mészáros T, Kozma GT, Shimizu T, Miyahara K, Turjeman K, Ishida T, et al. Involvement of complement activation in the pulmonary vasoactivity of polystyrene nanoparticles in pigs: Unique surface properties underlying alternative pathway activation and instant opsonization. International Journal of Nanomedicine [Internet]. 2018;13:6345–57. Available from:


Barenholz Y, Lasic DD. General preface [Internet]. Handbook of Nonmedical Applications of Liposomes: Volume III: From Design to Microreactors. 2018. Available from:


Barenholz Y, Lasic DD. Introduction to volume III [Internet]. Handbook of Nonmedical Applications of Liposomes: Volume III: From Design to Microreactors. 2018. Available from:


Lasic DD, Barenholz Y. Liposomes in catalysis [Internet]. Handbook of Nonmedical Applications of Liposomes: Volume III: From Design to Microreactors. 2018. Available from:


Lasic DD, Barenholz Y. Nonlipid llposomes and nonliposomal lipid particles [Internet]. Handbook of Nonmedical Applications of Liposomes: Volume III: From Design to Microreactors. 2018. Available from:


Barenholz Y. Optimization of amphiphile-based colloidal carriers [Internet]. Handbook of Nonmedical Applications of Liposomes: Volume III: From Design to Microreactors. 2018. Available from:


Cedrone E, Neun BW, Rodriguez J, Vermilya A, Clogston JD, McNeil SE, et al. Anticoagulants influence the performance of in vitro assays intended for characterization of nanotechnology-based formulations. Molecules [Internet]. 2018;23(1). Available from:


Barenholz Y, Lasic DD. An overview of liposome scaled-up production and quality control [Internet]. Handbook of Nonmedical Applications of Liposomes: Volume III: From Design to Microreactors. 2018. Available from:


Wei X, Patil Y, Ohana P, Amitay Y, Shmeeda H, Gabizon A, et al. Characterization of Pegylated Liposomal Mitomycin C Lipid-Based Prodrug (Promitil) by High Sensitivity Differential Scanning Calorimetry and Cryogenic Transmission Electron Microscopy. Molecular Pharmaceutics [Internet]. 2017;14(12):4339–45. Available from:


Andriyanov AV, Portnoy E, Koren E, Semenenko I, Eyal S, Goldberg SN, et al. Therapeutic efficacy of combined PEGylated liposomal doxorubicin and radiofrequency ablation: Comparing single and combined therapy in young and old mice. Journal of Controlled Release [Internet]. 2017;257:2–9. Available from:


Cern A, Marcus D, Tropsha A, Barenholz Y, Goldblum A. New drug candidates for liposomal delivery identified by computer modeling of liposomes’ remote loading and leakage. Journal of Controlled Release [Internet]. 2017;252:18–27. Available from:


Anchordoquy TJ, Barenholz Y, Boraschi D, Chorny M, Decuzzi P, Dobrovolskaia MA, et al. Mechanisms and Barriers in Cancer Nanomedicine: Addressing Challenges, Looking for Solutions. ACS Nano [Internet]. 2017;11(1):12–8. Available from:


Turjeman K, Barenholz Y. Liposomal nano-drugs based on amphipathic weak acid steroid prodrugs for treatment of inflammatory diseases. Journal of Drug Targeting [Internet]. 2016;24(9):805–20. Available from:


Shmeeda H, Amitay Y, Gorin J, Tzemach D, Mak L, Stern ST, et al. Coencapsulation of alendronate and doxorubicin in pegylated liposomes: a novel formulation for chemoimmunotherapy of cancer. Journal of Drug Targeting [Internet]. 2016;24(9):878–89. Available from:


Moallem E, Koren E, Ulmansky R, Pizov G, Barlev M, Barenholz Y, et al. A liposomal steroid nano-drug for treating systemic lupus erythematosus. Lupus [Internet]. 2016;25(11):1209–16. Available from:


Cern A, Michael-Gayego A, Bavli Y, Koren E, Goldblum A, Moses AE, et al. Nano-mupirocin: Enabling the parenteral activity of mupirocin. European Journal of Nanomedicine [Internet]. 2016;8(3):139–49. Available from:


Wei X, Cohen R, Barenholz Y. Insights into composition/structure/function relationships of Doxil® gained from “high-sensitivity” differential scanning calorimetry. European Journal of Pharmaceutics and Biopharmaceutics [Internet]. 2016;104:260–70. Available from:


Tinkle S, McNeil SE, Mühlebach S, Bawa R, Borchard G, Barenholz Y, et al. Nanomedicines: Addressing the scientific and regulatory gap [Internet]. Vol. 2, Handbook of Clinical Nanomedicine: Law, Business, Regulation, Safety, and Risk. 2016. Available from:


Barenholz Y. Amphipathic weak base loading into preformed liposomes having a transmembrane ammonium ion gradient: From the bench to approved doxil [Internet]. Vol. 2, Liposome Technology: Third Edition. 2016. Available from:


Szebeni J, Muggia F, Barenholz Y. Case study: complement activation related hypersensitivity reactions to pegylated liposomal doxorubicin - experimental and clinical evidence, mechanisms and approaches to inhibition [Internet]. Vol. 2, Handbook of Immunological Properties of Engineered Nanomaterials: Second Edition. 2016. Available from:


Barenholz Y. Doxil®: The first fda-approved nanodrug-from an idea to a product (January 2015 update) [Internet]. Vol. 1, Handbook of Clinical Nanomedicine: Nanoparticles, Imaging, Therapy and Clinical Applications. 2016. Available from:


Bawa R, Barenholz Y, Owen A. The challenge of regulating nanomedicine: Key issues. RSC Drug Discovery Series [Internet]. 2016;2016-January(51):290–314. Available from:


Barenholz YC. Doxils - the first fda-approved nano-drug: From basics via cmc, cell culture and animal studies to clinical use. RSC Drug Discovery Series [Internet]. 2016;2016-January(51):315–45. Available from:


Schilt Y, Berman T, Wei X, Barenholz Y, Raviv U. Using solution X-ray scattering to determine the high-resolution structure and morphology of PEGylated liposomal doxorubicin nanodrugs. Biochimica et Biophysica Acta - General Subjects [Internet]. 2016;1860(1):108–19. Available from:


Perlstein H, Turovsky T, Gimeson P, Cohen R, Rubinstein A, Danino D, et al. Thermotropic behavior of celecoxib-loaded beta-casein micelles: Relevance to the improved bioavailability. European Journal of Nanomedicine [Internet]. 2015;7(4):303–12. Available from:


Silverman L, Barenholz Y. In vitro experiments showing enhanced release of doxorubicin from Doxil® in the presence of ammonia may explain drug release at tumor site. Nanomedicine: Nanotechnology, Biology, and Medicine [Internet]. 2015;11(7):1841–50. Available from:


Turovsky T, Khalfin R, Kababya S, Schmidt A, Barenholz Y, Danino D. Celecoxib Encapsulation in β-Casein Micelles: Structure, Interactions, and Conformation. Langmuir [Internet]. 2015;31(26):7183–92. Available from:


Turjeman K, Bavli Y, Kizelsztein P, Schilt Y, Allon N, Katzir TB, et al. Nano-drugs based on nano sterically stabilized liposomes for the treatment of inflammatory neurodegenerative diseases. PLoS ONE [Internet]. 2015;10(7). Available from:


Shemi A, Khvalevsky EZ, Gabai RM, Domb A, Barenholz Y. Multistep, effective drug distribution within solid tumors. Oncotarget [Internet]. 2015;6(37):39564–77. Available from:


Perlstein H, Bavli Y, Turovsky T, Rubinstein A, Danino D, Stepensky D, et al. Beta-casein nanocarriers of celecoxib for improved oral bioavailability. European Journal of Nanomedicine [Internet]. 2014;6(4):217–26. Available from:


Andriyanov AV, Koren E, Barenholz Y, Goldberg SN. Therapeutic efficacy of combining PEGylated liposomal doxorubicin and radiofrequency (RF) ablation: Comparison between slow-drug-releasing, non-thermosensitive and fast-drug-releasing, thermosensitive nano-liposomes. PLoS ONE [Internet]. 2014;9(5). Available from:


Bavli D, Emanuel N, Barenholz Y. Real-time monitoring of E. coli O157 and Salmonella enterica serovar Typhimurium in water using ultrasound and latex-based immunoassay. Analytical Methods [Internet]. 2014;6(2):395–403. Available from:


Guo J, Waknine-Grinberg JH, Mitchell AJ, Barenholz Y, Golenser J. Reduction of experimental cerebral malaria and its related proinflammatory responses by the novel liposome-based β -methasone nanodrug. BioMed Research International [Internet]. 2014;2014. Available from:


Cern A, Nativ-Roth E, Goldblum A, Barenholz Y. Effect of solubilizing agents on mupirocin loading into and release from PEGylated nanoliposomes. Journal of Pharmaceutical Sciences [Internet]. 2014;103(7):2131–8. Available from:


Tinkle S, Mcneil SE, Mühlebach S, Bawa R, Borchard G, Barenholz YC, et al. Nanomedicines: Addressing the scientific and regulatory gap. Annals of the New York Academy of Sciences [Internet]. 2014;1313(1):35–56. Available from:


Cern A, Barenholz Y, Tropsha A, Goldblum A. Computer-aided design of liposomal drugs: In silico prediction and experimental validation of drug candidates for liposomal remote loading. Journal of Controlled Release [Internet]. 2014;173(1):125–31. Available from:


Cohen R, Steiner A, Kanaan H, Barenholz Y. Chemical and physical characterization of remotely loaded bupivacaine liposomes: Comparison between large multivesicular vesicles and small unilamellar vesicles. Journal of Materials Chemistry B [Internet]. 2013;1(36):4619–27. Available from:


Waknine-Grinberg JH, Even-Chen S, Avichzer J, Turjeman K, Bentura-Marciano A, Haynes RK, et al. Glucocorticosteroids in Nano-Sterically Stabilized Liposomes Are Efficacious for Elimination of the Acute Symptoms of Experimental Cerebral Malaria. PLoS ONE [Internet]. 2013;8(8). Available from:


Regev O, Barenholz Y, Peretz S, Zucker D, Bavli-Felsen Y. Can carbon nanotube-liposome conjugates address the issues associated with carbon nanotubes in drug delivery? Future Medicinal Chemistry [Internet]. 2013;5(5):503–5. Available from:


Even-or O, Samira S, Ellis R, Kedar E, Barenholz Y. Adjuvanted influenza vaccines. Expert Review of Vaccines [Internet]. 2013;12(9):1095–108. Available from:


Cern A, Golbraikh A, Sedykh A, Tropsha A, Barenholz Y, Goldblum A. Quantitative structure - Property relationship modeling of remote liposome loading of drugs. Journal of Controlled Release [Internet]. 2012;160(2):147–57. Available from:


Bachar M, Mandelbaum A, Portnaya I, Perlstein H, Even-Chen S, Barenholz Y, et al. Development and characterization of a novel drug nanocarrier for oral delivery, based on self-assembled β-casein micelles. Journal of Controlled Release [Internet]. 2012;160(2):164–71. Available from:


Karchemski F, Zucker D, Barenholz Y, Regev O. Carbon nanotubes-liposomes conjugate as a platform for drug delivery into cells. Journal of Controlled Release [Internet]. 2012;160(2):339–45. Available from:


Barenholz Y, Peer D. Liposomes and other assemblies as drugs and nano-drugs: From basic and translational research to the clinics. Journal of Controlled Release [Internet]. 2012;160(2):115–6. Available from:


Zucker D, Andriyanov AV, Steiner A, Raviv U, Barenholz Y. Characterization of PEGylated nanoliposomes co-remotely loaded with topotecan and vincristine: Relating structure and pharmacokinetics to therapeutic efficacy. Journal of Controlled Release [Internet]. 2012;160(2):281–9. Available from:


Cohen R, Kanaan H, Grant GJ, Barenholz Y. Prolonged analgesia from Bupisome and Bupigel formulations: From design and fabrication to improved stability. Journal of Controlled Release [Internet]. 2012;160(2):346–52. Available from:


Emanuel N, Rosenfeld Y, Cohen O, Applbaum YH, Segal D, Barenholz Y. A lipid-and-polymer-based novel local drug delivery system - BonyPid TM: From physicochemical aspects to therapy of bacterially infected bones. Journal of Controlled Release [Internet]. 2012;160(2):353–61. Available from:


Szebeni J, Bedocs P, Urbanics R, Bünger R, Rosivall L, Tóth M, et al. Prevention of infusion reactions to PEGylated liposomal doxorubicin via tachyphylaxis induction by placebo vesicles: A porcine model. Journal of Controlled Release [Internet]. 2012;160(2):382–7. Available from:


Barenholz Y. Doxil® - The first FDA-approved nano-drug: Lessons learned. Journal of Controlled Release [Internet]. 2012;160(2):117–34. Available from:


Ulmansky R, Turjeman K, Baru M, Katzavian G, Harel M, Sigal A, et al. Glucocorticoids in nano-liposomes administered intravenously and subcutaneously to adjuvant arthritis rats are superior to the free drugs in suppressing arthritis and inflammatory cytokines. Journal of Controlled Release [Internet]. 2012;160(2):299–305. Available from:


Barenholz Y, Peer D. Liposomes, lipid biophysics, and sphingolipid research: From basic to translation research. Chemistry and Physics of Lipids [Internet]. 2012;165(4):363–4. Available from:


Even-Chen S, Cohen R, Barenholz Y. Factors affecting DNA binding and stability of association to cationic liposomes. Chemistry and Physics of Lipids [Internet]. 2012;165(4):414–23. Available from:


Szebeni J, Bedocs P, Rozsnyay Z, Weiszhár Z, Urbanics R, Rosivall L, et al. Liposome-induced complement activation and related cardiopulmonary distress in pigs: Factors promoting reactogenicity of Doxil and AmBisome. Nanomedicine: Nanotechnology, Biology, and Medicine [Internet]. 2012;8(2):176–84. Available from:


Szebeni J, Barenholz YC. Complement activation, immunogenicity, and immune suppression as potential side effects of liposomes [Internet]. Handbook of Harnessing Biomaterials in Nanomedicine. 2012. Available from:


Barenholz YC. Doxil® - The first FDA-approved nano-drug: From an idea to a product [Internet]. Handbook of Harnessing Biomaterials in Nanomedicine. 2012. Available from:


Emanuel N, Segal D, Rosenfeld Y, Cohen O, Applbaum YH, Barenholz Y. BonyPidTM: A lipid-and-polymer-based novel local drug delivery system Physicochemical aspects and therapy. European Cells and Materials [Internet]. 2012;24(SUPPL. 1):42. Available from:


Barenholz Y, Barenholz C. Nanomedicine: Shake up the drug containers. Nature Nanotechnology [Internet]. 2012;7(8):483–4. Available from:


Ostrovsky LA, Priev A, Ponomarev V, Barenholz Y. Acoustic radiation force for rapid detection of particles in biological liquids. In: Proceedings of Meetings on Acoustics [Internet]. 2011. Available from:


Nadler-Milbauer M, Apter L, Haupt Y, Haupt S, Barenholz Y, Minko T, et al. Synchronized release of Doxil and Nutlin-3 by remote degradation of polysaccharide matrices and its possible use in the local treatment of colorectal cancer. Journal of Drug Targeting [Internet]. 2011;19(10):859–73. Available from:


Avnir Y, Turjeman K, Tulchinsky D, Sigal A, Kizelsztein P, Tzemach D, et al. Fabrication principles and their contribution to the superior in vivo therapeutic efficacy of nano-liposomes remote loaded with glucocorticoids. PLoS ONE [Internet]. 2011;6(10). Available from:


Szebeni J, Muggia F, Gabizon A, Barenholz Y. Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: Prediction and prevention. Advanced Drug Delivery Reviews [Internet]. 2011;63(12):1020–30. Available from:


Harel E, Rubinstein A, Nissan A, Khazanov E, Milbauer M, Barenholz Y, et al. Enhanced transferrin receptor expression by proinflammatory cytokines in enterocytes as a means for local delivery of drugs to inflamed gut mucosa. PLoS ONE [Internet]. 2011;6(9). Available from:


Goldberg R, Schroeder A, Silbert G, Turjeman K, Barenholz Y, Klein J. Boundary lubricants with exceptionally low friction coefficients based on 2D close-packed phosphatidylcholine liposomes. Advanced Materials [Internet]. 2011;23(31):3517–21. Available from:


Goldberg R, Schroeder A, Barenholz Y, Klein J. Interactions between adsorbed hydrogenated soy phosphatidylcholine (HSPC) vesicles at physiologically high pressures and salt concentrations. Biophysical Journal [Internet]. 2011;100(10):2403–11. Available from:


Barenholz Y, Bombelli C, Bonicelli MG, Profio PD, Giansanti L, Mancini G, et al. Influence of lipid composition on the thermotropic behavior and size distribution of mixed cationic liposomes. Journal of Colloid and Interface Science [Internet]. 2011;356(1):46–53. Available from:


Even-Or O, Joseph A, Itskovitz-Cooper N, Samira S, Rochlin E, Eliyahu H, et al. A new intranasal influenza vaccine based on a novel polycationic lipid-ceramide carbamoyl-spermine (CCS). II. Studies in mice and ferrets and mechanism of adjuvanticity. Vaccine [Internet]. 2011;29(13):2474–86. Available from:


Emanuel N, Segal D, Rosenfeld Y, Cohen O, Barenholz Y. The PolyPid - A novel local delivery system: From the physic-chemical aspects to innovative and superior therapeutic potential. European Cells and Materials [Internet]. 2011;21(SUPPL.2):17. Available from:


Lahav J, Herzberg M, Barenholz YC, Cabilly S, Kotler Y. Vision in venture: angels of innovation. Interviewed by Catarina Wylie. Cell cycle (Georgetown, Tex) [Internet]. 2011;10(10):1505–11. Available from:


Priev A, Barenholz Y. Ultrasonic food quality analyzer based on cylindrical standing waves. In: 20th International Congress on Acoustics 2010, ICA 2010 - Incorporating Proceedings of the 2010 Annual Conference of the Australian Acoustical Society [Internet]. 2010. p. 2708–11. Available from:


Schroeder A, Turjeman K, Schroeder JE, Leibergall M, Barenholz Y. Using liposomes to target infection and inflammation induced by foreign body injuries or medical implants. Expert Opinion on Drug Delivery [Internet]. 2010;7(10):1175–89. Available from:


Even-Or O, Samira S, Rochlin E, Balasingam S, Mann AJ, Lambkin-Williams R, et al. Immunogenicity, protective efficacy and mechanism of novel CCS adjuvanted influenza vaccine. Vaccine [Internet]. 2010;28(39):6527–41. Available from:


Zucker D, Barenholz Y. Optimization of vincristine-topotecan combination - Paving the way for improved chemotherapy regimens by nanoliposomes. Journal of Controlled Release [Internet]. 2010;146(3):326–33. Available from:


Waknine-Grinberg JH, Hunt N, Bentura-Marciano A, McQuillan JA, Chan HW, Chan WC, et al. Artemisone effective against murine cerebral malaria. Malaria Journal [Internet]. 2010;9(1). Available from:


Khazanov E, Emmanuel N, Azab AK, Barenholz Y, Yavin E, Rubinstein A. Specific detection of gastric α-antitrypsin by immobilized trypsin on PolyHEMA films. Molecular Pharmaceutics [Internet]. 2010;7(4):944–52. Available from:


Verberne G, Schroeder A, Halperin G, Barenholz Y, Etsion I. Liposomes as potential biolubricant additives for wear reduction in human synovial joints. Wear [Internet]. 2010;268(7–8):1037–42. Available from:


Sivan S, Schroeder A, Verberne G, Merkher Y, Diminsky D, Priev A, et al. Liposomes act as effective biolubricants for friction reduction in human synovial joints. Langmuir [Internet]. 2010;26(2):1107–16. Available from:


Davidson EM, Barenholz Y, Cohen R, Haroutiunian S, Kagan L, Ginosar Y. High-dose bupivacaine remotely loaded into multivesicular liposomes demonstrates slow drug release without systemic toxic plasma concentrations after subcutaneous administration in humans. Anesthesia and Analgesia [Internet]. 2010;110(4):1018–23. Available from:


Schroeder A, Kost J, Barenholz Y. Ultrasound, liposomes, and drug delivery: principles for using ultrasound to control the release of drugs from liposomes. Chemistry and Physics of Lipids [Internet]. 2009;162(1–2):1–16. Available from:


Zucker D, Marcus D, Barenholz Y, Goldblum A. Liposome drugs’ loading efficiency: A working model based on loading conditions and drug’s physicochemical properties. Journal of Controlled Release [Internet]. 2009;139(1):73–80. Available from:


Schroedera A, Verberne G, Merkherc Y, Diminsky D, Maroudes A, Halperin G, et al. Surface active phospholipids as cartilage lubricants. In: 2008 Proceedings of the 9th Biennial Conference on Engineering Systems Design and Analysis [Internet]. 2009. p. 549–53. Available from:


Kizelsztein P, Ovadia H, Garbuzenko O, Sigal A, Barenholz Y. Pegylated nanoliposomes remote-loaded with the antioxidant tempamine ameliorate experimental autoimmune encephalomyelitis. Journal of Neuroimmunology [Internet]. 2009;213(1–2):20–5. Available from:


Tirosh B, Khatib N, Barenholz Y, Nissan A, Rubinstein A. Transferrin as a luminal target for negatively charged liposomes in the inflamed colonic mucosa. Molecular Pharmaceutics [Internet]. 2009;6(4):1083–91. Available from:


Schroeder A, Honen R, Turjeman K, Gabizon A, Kost J, Barenholz Y. Ultrasound triggered release of cisplatin from liposomes in murine tumors. Journal of Controlled Release [Internet]. 2009;137(1):63–8. Available from:


Waknine-Grinberg JH, El-On J, Barak V, Barenholz Y, Golenser J. The immunomodulatory effect of Sambucol on leishmanial and malarial infections. Planta Medica [Internet]. 2009;75(6):581–6. Available from:


Nadler-Milbauer M, Azab AK, Kleinstern J, Barenholz Y, Rubinstein A. In vitro and in vivo analysis of pulsatile biodegradation of mucoadhesive hydrogels. Journal of Drug Delivery Science and Technology [Internet]. 2009;19(4):247–55. Available from:


Schroeder A, Sigal A, Turjeman K, Barenholz Y. Using PEGylated nano-liposomes to target tissue invaded by a foreign body. Journal of Drug Targeting [Internet]. 2008;16(7–8):591–5. Available from:


Khazanov E, Priev A, Shillemans JP, Barenholz Y. Physicochemical and biological characterization of ceramide-containing liposomes: Paving the way to ceramide therapeutic application. Langmuir [Internet]. 2008;24(13):6965–80. Available from:


Shmeeda HR, Golden EB, Barenholz Y. Membrane Lipids and Aging [Internet]. Biomembranes, Biomembranes: Structural and Functional Aspects. 2008. Available from:


Avnir Y, Ulmansky R, Wasserman V, Even-Chen S, Broyer M, Barenholz Y, et al. Amphipathic weak acid glucocorticoid prodrugs remote-loaded into sterically stabilized nanoliposomes evaluated in arthritic rats and in a Beagle dog: A novel approach to treating autoimmune arthritis. Arthritis and Rheumatism [Internet]. 2008;58(1):119–29. Available from:


Boktov J, Hirsch-Lerner D, Barenholz Y. Characterization of the interplay between the main factors contributing to lipoplex-mediated transfection in cell cultures. Journal of Gene Medicine [Internet]. 2007;9(10):884–93. Available from:


Eliyahu H, Joseph A, Schillemans JP, Azzam T, Domb AJ, Barenholz Y. Characterization and in vivo performance of dextran-spermine polyplexes and DOTAP/cholesterol lipoplexes administered locally and systemically. Biomaterials [Internet]. 2007;28(14):2339–49. Available from:


Szebeni J, Alving CR, Rosivall L, Bünger R, Baranyi L, Bedöcs P, et al. Animal models of complement-mediated hypersensitivity reactions to liposomes and other lipid-based nanoparticles. Journal of Liposome Research [Internet]. 2007;17(2):107–17. Available from:


Schroeder A, Avnir Y, Weisman S, Najajreh Y, Gabizon A, Talmon Y, et al. Controlling liposomal drug release with low frequency ultrasound: Mechanism and feasibility. Langmuir [Internet]. 2007;23(7):4019–25. Available from:


Wasserman V, Kizelsztein P, Garbuzenko O, Kohen R, Ovadia H, Tabakman R, et al. The antioxidant tempamine: In vitro antitumor and neuroprotective effects and optimization of liposomal encapsulation and release. Langmuir [Internet]. 2007;23(4):1937–47. Available from:


Lichtenberg D, Barenholz Y. Liposomes: Preparation, characterization, and preservation [Internet]. Vol. 33, Methods of Biochemical Analysis. 2006. Available from:


Khazanov E, Simberg D, Barenholz Y. Lipoplexes prepared from cationic liposomes and mammalian DNA induce CpG-independent, direct cytotoxic effects in cell cultures and in mice. Journal of Gene Medicine [Internet]. 2006;8(8):998–1007. Available from:


Najajreh Y, Khazanov E, Jawbry S, Ardeli-Tzaraf Y, Perez JM, Kasparkova J, et al. Cationic nonsymmetric transplatinum complexes with piperidinopiperidine ligands. Preparation, characterization, in vitro cytotoxicity, in vivo toxicity, and anticancer efficacy studies. Journal of Medicinal Chemistry [Internet]. 2006;49(15):4665–73. Available from:


Najajreh Y, Ardeli-Tzaraf Y, Kasparkova J, Heringova P, Prilutski D, Balter L, et al. Interactions of platinum complexes containing cationic, bicyclic, nonplanar piperidinopiperidine ligands with biological nucleophiles. Journal of Medicinal Chemistry [Internet]. 2006;49(15):4674–83. Available from:


Mitchell LA, Joseph A, Kedar E, Barenholz Y, Galun E. Mucosal immunization against hepatitis A: Antibody responses are enhanced by co-administration of synthetic oligodeoxynucleotides and a novel cationic lipid. Vaccine [Internet]. 2006;24(25):5300–10. Available from:


Joseph A, Itskovitz-Cooper N, Samira S, Flasterstein O, Eliyahu H, Simberg D, et al. A new intranasal influenza vaccine based on a novel polycationic lipid-ceramide carbamoyl-spermine (CCS). I. Immunogenicity and efficacy studies in mice. Vaccine [Internet]. 2006;24(18):3990–4006. Available from:


Avnir Y, Barenholz Y. Erratum: pH determination by pyranine: Medium-related artifacts and their correction (Analytical Biochemistry (2005) 347 (34-41) DOI: 10.1016/j.ab.2005. 09.026). Analytical Biochemistry [Internet]. 2006;351(2):317. Available from:


Jubeh TT, Nadler-Milbauer M, Barenholz Y, Rubinstein A. Local treatment of experimental colitis in the rat by negatively charged liposomes of catalase, TMN and SOD. Journal of Drug Targeting [Internet]. 2006;14(3):155–63. Available from:


Eliyahu H, Joseph A, Azzam T, Barenholz Y, Domb AJ. Dextran-spermine-based polyplexes - Evaluation of transgene expression and of local and systemic toxicity in mice. Biomaterials [Internet]. 2006;27(8):1636–45. Available from:


Eliyahu H, Siani S, Azzam T, Domb AJ, Barenholz Y. Relationships between chemical composition, physical properties and transfection efficiency of polysaccharide-spermine conjugates. Biomaterials [Internet]. 2006;27(8):1646–55. Available from:


Meidan VM, Glezer J, Salomon S, Sidi Y, Barenholz Y, Cohen JS, et al. Specific lipoplex-mediated antisense against Bcl-2 in breast cancer cells: A comparison between different formulations. Journal of Liposome Research [Internet]. 2006;16(1):27–43. Available from:


Avnir Y, Barenholz Y. pH determination by pyranine: Medium-related artifacts and their correction. Analytical Biochemistry [Internet]. 2005;347(1):34–41. Available from:


Simberg D, Weiss A, Barenholz Y. Reversible mode of binding of serum proteins to DOTAP/cholesterol lipoplexes: A possible explanation for intravenous lipofection efficiency. Human Gene Therapy [Internet]. 2005;16(9):1087–96. Available from:


Barenholz Y, Yarmut Y. Enzymatic phospholipid transesterification. Industrial Bioprocessing [Internet]. 2005;27(9):8–9. Available from:


Hirsch-Lerner D, Zhang M, Eliyahu H, Ferrari ME, Wheeler CJ, Barenholz Y. Effect of “helper lipid” on lipoplex electrostatics. Biochimica et Biophysica Acta - Biomembranes [Internet]. 2005;1714(2):71–84. Available from:


Baru M, Carmel-Goren L, Barenholz Y, Dayan I, Ostropolets S, Slepoy I, et al. Factor VIII efficient and specific non-covalent binding to PEGylated liposomes enables prolongation of its circulation time and haemostatic efficacy. Thrombosis and Haemostasis [Internet]. 2005;93(6):1061–8. Available from:


Garbuzenko O, Barenholz Y, Priev A. Effect of grafted PEG on liposome size and on compressibility and packing of lipid bilayer. Chemistry and Physics of Lipids [Internet]. 2005;135(2):117–29. Available from:


Najajreh Y, Prilutski D, Ardeli-Tzaraf Y, Perez JM, Khazanov E, Barenholz Y, et al. Structure and unique interactions with DNA of a cationic Trans-platinum complex with the nonplanar bicyclic piperidinopiperidine ligand. Angewandte Chemie - International Edition [Internet]. 2005;44(19):2885–7. Available from:


Garbuzenko O, Zalipsky S, Qazen M, Barenholz Y. Electrostatics of PEGylated micelles and liposomes containing charged and neutral lipopolymers. Langmuir [Internet]. 2005;21(6):2560–8. Available from:


Eliyahu H, Makovitzki A, Azzam T, Zlotkin A, Joseph A, Gazit D, et al. Novel dextran - Spermine conjugates as transfecting agents: Comparing water-soluble and micellar polymers. Gene Therapy [Internet]. 2005;12(6):494–503. Available from:


Eliyahu H, Barenholz Y, Domb AJ. Polymers for DNA delivery. Molecules [Internet]. 2005;10(1):34–64. Available from:


Jubeh TT, Antler S, Haupt S, Barenholz Y, Rubinstein A. Local prevention of oxidative stress in the intestinal epithelium of the rat by adhesive liposomes of superoxide dismutase and tempamine. Molecular Pharmaceutics [Internet]. 2005;2(1):2–11. Available from:


Kalmanzon E, Rahamim Y, Carmeli S, Barenholz Y, Zlotkin E. Endogenous regulation of the functional duality of pahutoxin, a marine trunkfish surfactant. Toxicon [Internet]. 2004;44(8):939–42. Available from:


Simberg D, Weisman S, Talmon Y, Barenholz Y. DOTAP (and other cationic lipids): Chemistry, biophysics, and transfection. Critical Reviews in Therapeutic Drug Carrier Systems [Internet]. 2004;21(4):257–317. Available from:


Grant GJ, Barenholz Y, Bolotin EM, Bansinath M, Turndorf H, Piskoun B, et al. A novel liposomal bupivacaine formulation to produce ultralong-acting analgesia. Anesthesiology [Internet]. 2004;101(1):133–7. Available from:


Jubeh TT, Barenholz Y, Rubinstein A. Differential adhesion of normal and inflamed rat colonic mucosa by charged liposomes. Pharmaceutical Research [Internet]. 2004;21(3):447–53. Available from:


Barenholz Y. Sphingomyelin and cholesterol: from membrane biophysics and rafts to potential medical applications. Sub-cellular biochemistry [Internet]. 2004;37:167–215. Available from:


Samuni AM, Barenholz Y. Use of nitroxides to protect liposomes against oxidative damage. Methods in enzymology [Internet]. 2004;387:299–314. Available from:


Weisman S, Hirsch-Lerner D, Barenholz Y, Talmon Y. Nanostructure of cationic lipid-oligonucleotide complexes. Biophysical Journal [Internet]. 2004;87(1):609–14. Available from:


Simberg D, Weisman S, Talmon Y, Faerman A, Shoshani T, Barenholz Y. The role of organ vascularization and lipoplex-serum initial contact in intravenous murine lipofection. Journal of Biological Chemistry [Internet]. 2003;278(41):39858–65. Available from:


Ben-Yehuda A, Joseph A, Barenholz Y, Zeira E, Even-Chen S, Louria-Hayon I, et al. Immunogenicity and safety of a novel IL-2-supplemented liposomal influenza vaccine (INFLUSOME-VAC) in nursing-home residents. Vaccine [Internet]. 2003;21(23):3169–78. Available from:


Gabizon A, Shmeeda H, Barenholz Y. Pharmacokinetics of pegylated liposomal doxorubicin: Review of animal and human studies. Clinical Pharmacokinetics [Internet]. 2003;42(5):419–36. Available from:


Zvulunov A, Cagnano E, Frankenburg S, Barenholz Y, Vardy D. Topical treatment of persistent cutaneous leishmaniasis with ethanolic lipid amphotericin B. Pediatric Infectious Disease Journal [Internet]. 2003;22(6):567–9. Available from:


Barenholz A, Fishel F, Yakir E, Gatt S, Barenholz Y, Bercovier H. Liposomes enhance bioremediation of oil-contaminated soil. Journal of Liposome Research [Internet]. 2003;13(2):173–86. Available from:


Barenholz Y. Relevancy of drug loading to liposomal formulation therapeutic efficacy. Journal of Liposome Research [Internet]. 2003;13(1):1–8. Available from:


Ben-Yehuda A, Joseph A, Zeira E, Even-Chen S, Louria-Hayon I, Babai I, et al. Immunogenicity and safety of a novel liposomal influenza subunit vaccine (INFLUSOME-VAC) in young adults. Journal of Medical Virology [Internet]. 2003;69(4):560–7. Available from:


Samuni AM, Barenholz Y. Site-activity relationship of nitroxide radical’s antioxidative effect. Free Radical Biology and Medicine [Internet]. 2003;34(2):177–85. Available from:


Shmeeda H, Even-Chen S, Honen R, Cohen R, Weintraub C, Barenholz Y. Enzymatic Assays for Quality Control and Pharmacokinetics of Liposome Formulations: Comparison with Nonenzymatic Conventional Methodologies. Methods in Enzymology [Internet]. 2003;367:272–92. Available from:


Kalmanzon E, Rahamim Y, Barenholz Y, Carmeli S, Zlotkin E. Receptor-mediated toxicity of pahutoxin, a marine trunkfish surfactant. Toxicon [Internet]. 2003;42(1):63–71. Available from:


Khazanov E, Barenholz Y, Gibson D, Najajreh Y. Novel apoptosis-inducing trans-platinum piperidine derivatives: Synthesis and biological characterization. Journal of Medicinal Chemistry [Internet]. 2002;45(24):5196–204. Available from:


Joseph A, Louria-Hayon I, Plis-Finarov A, Zeira E, Zakay-Rones Z, Raz E, et al. Liposomal immunostimulatory DNA sequence (ISS-ODN): An efficient parenteral and mucosal adjuvant for influenza and hepatitis B vaccines. Vaccine [Internet]. 2002;20(27–28):3342–54. Available from:


Szebeni J, Baranyi L, Savay S, Milosevits J, Bunger R, Laverman P, et al. Role of complement activation in hypersensitivity reactions to Doxil and HYNIC PEG liposomes: Experimental and clinical studies. Journal of Liposome Research [Internet]. 2002;12(1–2):165–72. Available from:


Azzam T, Eliyahu H, Shapira L, Linial M, Barenholz Y, Domb AJ. Polysaccharide-oligoamine based conjugates for gene delivery. Journal of Medicinal Chemistry [Internet]. 2002;45(9):1817–24. Available from:


Priev A, Zalipsky S, Cohen R, Barenholz Y. Determination of critical micelle concentration of lipopolymers and other amphiphiles: Comparison of sound velocity and fluorescent measurements. Langmuir [Internet]. 2002;18(3):612–7. Available from:


Azzam T, Eliyahu H, Raskin A, Makovitzki A, Barenholz Y, Lineal M, et al. Cationic polysaccharides as vectors for gene delivery. In: American Chemical Society, Polymer Preprints, Division of Polymer Chemistry [Internet]. 2002. p. 671–2. Available from:


Eliyahu N, Servel N, Domb AJ, Barenholz Y. Magnetic properties of iron-containing particles in a quartz matrix after mechanochemical processing. Inorganic Materials [Internet]. 2002;38(2):132–6. Available from:


Shmeeda H, Kaspler P, Shleyer J, Honen R, Horowitz M, Barenholz Y. Heat acclimation in rats: Modulation via lipid polyunsaturation. American Journal of Physiology - Regulatory Integrative and Comparative Physiology [Internet]. 2002;283(2 52-2):R389–99. Available from:


Eliyahu N, Servel N, Domb AJ, Barenholz Y. Lipoplex-induced hemagglutination: Potential involvement in intravenous gene delivery. Gene Therapy [Internet]. 2002;9(13):850–8. Available from:


Barenholz Y. Cholesterol and other membrane active sterols: from membrane evolution to “rafts.” Progress in Lipid Research [Internet]. 2002;41(1):1–5. Available from:


Meidan VM, Glezer J, Amariglio N, Cohen JS, Barenholz Y. Oligonucleotide lipoplexes: The influence of oligonucleotide composition on complexation. Biochimica et Biophysica Acta - General Subjects [Internet]. 2001;1568(3):177–82. Available from:


Simberg D, Danino D, Talmon Y, Minsky A, Ferrari ME, Wheeler CJ, et al. Phase behavior, DNA ordering, and size instability of cationic lipoplexes: Relevance to optimal transfection activity. Journal of Biological Chemistry [Internet]. 2001;276(50):47453–9. Available from:


Babai I, Barenholz Y, Zakay-Rones Z, Greenbaum E, Samira S, Hayon I, et al. A novel liposomal influenza vaccine (INFLUSOME-VAC) containing hemagglutinin-neuraminidase and IL-2 or GM-CSF induces protective anti-neuraminidase antibodies cross-reacting with a wide spectrum of influenza A viral strains. Vaccine [Internet]. 2001;20(3–4):505–15. Available from:


Grant GJ, Barenholz Y, Piskoun B, Bansinath M, Turndorf H, Bolotin EM. DRV liposomal bupivacaine: Preparation, characterization, and in vivo evaluation in mice. Pharmaceutical Research [Internet]. 2001;18(3):336–43. Available from:


Kerner M, Meyuhas O, Hirsch-Lerner D, Rosen LJ, Min Z, Barenholz Y. Interplay in lipoplexes between type of pDNA promoter and lipid composition determines transfection efficiency of human growth hormone in NIH3T3 cells in culture. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids [Internet]. 2001;1532(1–2):128–36. Available from:


Barenholz Y. Liposome application: Problems and prospects. Current Opinion in Colloid and Interface Science [Internet]. 2001;6(1):66–77. Available from:


Szebeni J, Alving CR, Savay S, Barenholz Y, Priev A, Danino D, et al. Formation of complement-activating particles in aqueous solutions of Taxol: Possible role in hypersensitivity reactions. International Immunopharmacology [Internet]. 2001;1(4):721–35. Available from:


Peleg-Shulman T, Gibson D, Cohen R, Abra R, Barenholz Y. Characterization of sterically stabilized cisplatin liposomes by nuclear magnetic resonance. Biochimica et Biophysica Acta - Biomembranes [Internet]. 2001;1510(1–2):278–91. Available from:


Kalmanzon E, Aknin-Herrman R, Rahamim Y, Carmeli S, Barenholz Y, Zlotkin E. Cooperative cocktail in a chemical defence mechanism of a trunkfish. Cellular and Molecular Biology Letters [Internet]. 2001;6(4):971–84. Available from:


Vardy D, Barenholz Y, Naftoliev N, Klaus S, Gilead L, Frankenburg S. Efficacious topical treatment for human cutaneous leishmaniasis with ethanolic lipid amphotericin B. Transactions of the Royal Society of Tropical Medicine and Hygiene [Internet]. 2001;95(2):184–6. Available from:


Even-Chen S, Barenholz Y. DOTAP cationic liposomes prefer relaxed over supercoiled plasmids. Biochimica et Biophysica Acta - Biomembranes [Internet]. 2000;1509(1–2):176–88. Available from:


Meidan VM, Cohen JS, Amariglio N, Hirsch-Lerner D, Barenholz Y. Interaction of oligonucleotides with cationic lipids: The relationship between electrostatics, hydration and state of aggregation. Biochimica et Biophysica Acta - Biomembranes [Internet]. 2000;1464(2):251–61. Available from:


Samuni AM, Lipman A, Barenholz Y. Damage to liposomal lipids: Protection by antioxidants and cholesterol- mediated dehydration. Chemistry and Physics of Lipids [Internet]. 2000;105(2):121–34. Available from:


Kedar E, Gur H, Babai I, Samira S, Even-Chen S, Barenholz Y. Delivery of cytokines by liposomes: Hematopoietic and immunomodulatory activity of interleukin-2 encapsulated in conventional liposomes and in long- circulating liposomes. Journal of Immunotherapy [Internet]. 2000;23(1):131–45. Available from:


Kedar E, Gur H, Babai I, Samira S, Even-Chen S, Barenholz Y. Delivery of cytokines by liposomes: hematopoietic and immunomodulatory activity of interleukin-2 encapsulated in conventional liposomes and in long-circulating liposomes. Journal of Immunotherapy [Internet]. 2000;23(1):4759. Available from:


Barenholz Y. Liposomology. Progress in Lipid Research [Internet]. 2000;39(1):1–2. Available from:


Simberg D, Hirsch-Lerner D, Nissim R, Barenholz Y. Comparison of different commercially available cationic lipid-based transfection kits. Journal of Liposome Research [Internet]. 2000;10(1):1–13. Available from:


Hirsch-Lerner D, Barenholz Y. Hydration of lipoplexes commonly used in gene delivery: Follow-up by laurdan fluorescence changes and quantification by differential scanning calorimetry. Biochimica et Biophysica Acta - Biomembranes [Internet]. 1999;1461(1):47–57. Available from:


Samet D, Barenholz Y. Characterization of acidic and neutral sphingomyelinase activities in crude extracts of HL-60 cells. Chemistry and Physics of Lipids [Internet]. 1999;102(1–2):65–77. Available from:


Zuidam NJ, Barenholz Y, Minsky A. Chiral DNA packaging in DNA-cationic liposome assemblies. FEBS Letters [Internet]. 1999;457(3):419–22. Available from:


Diminsky D, Moav N, Gorecki M, Barenholz Y. Physical, chemical and immunological stability of CHO-derived hepatitis B surface antigen (HBsAg) particles. Vaccine [Internet]. 1999;18(1–2):3–17. Available from:


Naslavsky N, Shmeeda H, Friedlander G, Yanai A, Futerman AH, Barenholz Y, et al. Sphingolipid depletion increases formation of the scrapie prion protein in neuroblastoma cells infected with prions. Journal of Biological Chemistry [Internet]. 1999;274(30):20763–71. Available from:


Zuidam NJ, Hirsch-Lerner D, Margulies S, Barenholz Y. Lamellarity of cationic liposomes and mode of preparation of lipoplexes affect transfection efficiency. Biochimica et Biophysica Acta - Biomembranes [Internet]. 1999;1419(2):207–20. Available from:


Vardy D, Barenholz Y, Cohen R, Zvulunov A, Biton A, Klaus S, et al. Topical amphotericin B for cutaneous leishmaniasis [8]. Archives of Dermatology [Internet]. 1999;135(7):856–7. Available from:


Bandak S, Ramu A, Barenholz Y, Gabizon A. Reduced UV-induced degradation of doxorubicin encapsulated in polyethyleneglycol-coated liposomes. Pharmaceutical Research [Internet]. 1999;16(6):841–6. Available from:


Zuidam NJ, Barenholz Y. Characterization of DNA-lipid complexes commonly used for gene delivery. International Journal of Pharmaceutics [Internet]. 1999;183(1):43–6. Available from:


Babai I, Samira S, Barenholz Y, Zakay-Rones Z, Kedar E. A novel influenza subunit vaccine composed of liposome-encapsulated haemagglutinin/neuraminidase and IL-2 or GM-CSF. II. Induction of TH1 and TH2 responses in mice. Vaccine [Internet]. 1999;17(9–10):1239–50. Available from:


Babai I, Samira S, Barenholz Y, Zakay-Rones Z, Kedar E. A novel influenza subunit vaccine composed of liposome-encapsulated haemagglutinin/neuraminidase and IL-2 or GM-CSF. I. Vaccine characterization and efficacy studies in mice. Vaccine [Internet]. 1999;17(9–10):1223–38. Available from:


Cabanes A, Even-Chen S, Zimberoff J, Barenholz Y, Kedar E, Gabizon A. Enhancement of antitumor activity of polyethylene glycol-coated liposomal doxorubicin with soluble and liposomal interleukin 2. Clinical Cancer Research [Internet]. 1999;5(3):687–93. Available from:


Grant GJ, Barenholz Y, Piskoun B, Bolotin EM, Turndorf H. A novel liposomal bupivacaine formulation using an ammonium sulfate gradient. Regional Anesthesia and Pain Medicine [Internet]. 1999;24(3 SUPPL.):42. Available from:


Tirosh O, Katzhendler J, Barenholz Y, Kohen R. Low-Density Lipoprotein Oxidation and Its Prevention by Amidothionophosphate Antioxidants. Antioxidants and Redox Signaling [Internet]. 1999;1(3):325–38. Available from:


Korablyov V, Zimran A, Barenholz Y. Cerebroside-β-glucosidase encapsulation in liposomes for Gaucher’s disease treatment revisited. Pharmaceutical Research [Internet]. 1999;16(3):466–9. Available from:


Bangham AD, Nicolau C, Alving CR, Nir S, Barenholz Y, Gabizon A, et al. Letter to the editor (multiple letters). Journal of Liposome Research [Internet]. 1999;9(1):155–79. Available from:


Barenholz Y, Gatt S. Preface. Chemistry and Physics of Lipids [Internet]. 1999;102(1–2):1–2. Available from:


Barenholz Y, Thompson TE. Sphingomyelin: Biophysical aspects. Chemistry and Physics of Lipids [Internet]. 1999;102(1–2):29–34. Available from:


Tirosh O, Katzhendler Y, Barenholz Y, Kohen R. Antioxidant activity of amidothionophosphates. Methods in Enzymology [Internet]. 1999;299:293–300. Available from:


Clerc S, Barenholz Y. A quantitative model for using acridine orange as a transmembrane pH gradient probe. Analytical Biochemistry [Internet]. 1998;259(1):104–11. Available from:


Gabizon A, Goren D, Cohen R, Barenholz Y. Development of liposomal anthracyclines: From basics to clinical applications. Journal of Controlled Release [Internet]. 1998;53(1–3):275–9. Available from:


Hirsch-Lerner D, Barenholz Y. Probing DNA-cationic lipid interactions with the fluorophore trimethylammonium diphenyl-hexatriene (TMADPH). Biochimica et Biophysica Acta - Biomembranes [Internet]. 1998;1370(1):17–30. Available from:


Zuidam NJ, Barenholz Y. Electrostatic and structural properties of complexes involving plasmid DNA and cationic lipids commonly used for gene delivery. Biochimica et Biophysica Acta - Biomembranes [Internet]. 1998;1368(1):115–28. Available from:


Samuni AM, Crommelin DJA, Zuidam NJ, Barenholz Y. Differential scanning calorimetry. A tool to assess physical and chemical alterations in liposomes. Journal of Thermal Analysis and Calorimetry [Internet]. 1998;51(1):37–48. Available from:


Tirosh O, Barenholz Y, Katzhendler J, Priev A. Hydration of polyethylene glycol-grafted liposomes. Biophysical Journal [Internet]. 1998;74(3):1371–9. Available from:


Moses AE, Rahav G, Barenholz Y, Elidan J, Azaz B, Gillis S, et al. Rhinocerebral mucormycosis treated with amphotericin B colloidal dispersion in three patients. Clinical Infectious Diseases [Internet]. 1998;26(6):1430–3. Available from:


Zuidam NJ, Barenholz Y. Erratum: Electrostatic parameters of cationic liposomes commonly used for gene delivery as determined by 4-heptadecyl-7-hydroxycoumarin’ (Biochim. Biophys. Acta 1329 (1997) (211-222) PII: 20005273697001107). Biochimica et Biophysica Acta - Biomembranes [Internet]. 1998;1372(1):151–151. Available from:


Frankenburg S, Glick D, Klaus S, Barenholz Y. Efficacious topical treatment for murine cutaneous leishmaniasis with ethanolic formulations of amphotericin B. Antimicrobial Agents and Chemotherapy [Internet]. 1998;42(12):3092–6. Available from:


Kedar E, Palgi O, Golod G, Babai I, Barenholz Y. Delivery of cytokines by liposomes. III. Liposome-encapsulated GM-CSF and TNF-α show improved pharmacokinetics and biological activity and reduced toxicity in mice. Journal of Immunotherapy [Internet]. 1997;20(3):180–93. Available from:


Samuni AM, Barenholz Y, Crommelin DJA, Zuidam NJ. γ-irradiation damage to liposomes differing in composition and their protection by nitroxides. Free Radical Biology and Medicine [Internet]. 1997;23(7):972–9. Available from:


Zuidam NJ, Barenholz Y. Electrostatic parameters of cationic liposomes commonly used for gene delivery as determined by 4-heptadecyl-7-hydroxycoumarin. Biochimica et Biophysica Acta - Biomembranes [Internet]. 1997;1329(2):211–22. Available from:


Tirosh O, Kohen R, Katzhendler J, Alon A, Barenholz Y. Oxidative stress effect on the integrity of lipid bilayers is modulated by cholesterol level of bilayers. Chemistry and Physics of Lipids [Internet]. 1997;87(1):17–22. Available from:


Diminsky D, Schirmbeck R, Reimann J, Barenholz Y. Comparison between hepatitis B surface antigen (HBsAg) particles derived from mammalian cells (CHO) and yeast cells (Hansenula polymorpha): Composition, structure and immunogenicity. Vaccine [Internet]. 1997;15(6–7):637–47. Available from:


Bar LK, Barenholz Y, Thompson TE. Effect of sphingomyelin composition on the phase structure of phosphatidylcholine- phingomyelin bilayers. Biochemistry [Internet]. 1997;36(9):2507–16. Available from:


Eckstein M, Barenholz Y, Bar LK, Segal E. Liposomes containing Candida albicans ribosomes as a prophylactic vaccine against disseminated candidiasis in mice. Vaccine [Internet]. 1997;15(2):220–4. Available from:


Felgner PL, Barenholz Y, Behr JP, Cheng SH, Cullis P, Huang L, et al. Nomenclature for synthetic gene delivery systems. Human Gene Therapy [Internet]. 1997;8(5):511–2. Available from:


Samuni AM, Barenholz Y. Stable nitroxide radicals protect lipid acyl chains from radiation damage. Free Radical Biology and Medicine [Internet]. 1997;22(7):1165–74. Available from:


Tirosh O, Kohen R, Katzhendler J, Gorodetsky R, Barenholz Y. Novel synthetic phospholipid protects lipid bilayers against oxidation damage: Role of hydration layer and bound water. Journal of the Chemical Society Perkin Transactions 2 [Internet]. 1997;(2):383–9. Available from:


Glick D, Barenholz Y. IgG immunoglobulins induce activation of the sphingomyelin cycle in HL-60 cells. FEBS Letters [Internet]. 1996;394(3):237–40. Available from:


Emanuel N, Kedar E, Bolotin EM, Smorodinsky NI, Barenholz Y. Targeted delivery of doxorubicin via sterically stabilized immunoliposomes: Pharmacokinetics and biodistribution in tumor-bearing mice. Pharmaceutical Research [Internet]. 1996;13(6):861–8. Available from:


Emanuel N, Kedar E, Bolotin EM, Smorodinsky NI, Barenholz Y. Preparation and characterization of doxorubicin-loaded sterically stabilized immunoliposomes. Pharmaceutical Research [Internet]. 1996;13(3):352–9. Available from:


Pop E, Soti F, Brewster ME, Barenholz Y, Korablyov V, Mechoulam R, et al. Derivatives of dexanabinol. II. Salts of amino acid esters containing tertiary and quaternary heterocyclic nitrogen with increased water-solubility. Pharmaceutical Research [Internet]. 1996;13(3):469–75. Available from:


Pop E, Liu ZZ, Brewster ME, Barenholz Y, Korablyov V, Mechoulam R, et al. Derivatives of dexanabinol. I. Water-soluble salts of glycinate esters. Pharmaceutical Research [Internet]. 1996;13(1):62–9. Available from:


Barenholz Y, Cohen T, Haas E, Ottolenghi M. Lateral organization of pyrene-labeled lipids in bilayers as determined from the deviation from equilibrium between pyrene monomers and excimers. Journal of Biological Chemistry [Internet]. 1996;271(6):3085–90. Available from:


Barenholz Y, Bolotin E, Cohen R, Gabizon A. Sterically stabilized doxorubicin loaded liposomes (DOX-SLTM): From basics to the clinics. Phosphorus, Sulfur and Silicon and Related Elements [Internet]. 1996;109(1–4):293–6. Available from:


Tirosh O, Katzhendler Y, Barenholz Y, Ginsburg I, Kohen R. Antioxidant properties of amidothionophosphates: Novel antioxidant molecules. Free Radical Biology and Medicine [Internet]. 1996;20(3):421–32. Available from:


Zomber G, Bogin E, Barenholz Y. Effect of I.V. injection of small unilamellar liposomes of egg phosphatidylcholine on cholesterol in plasma and erythrocytes, serum enzymes and liver function in dogs. Journal of Liposome Research [Internet]. 1996;6(2):455–77. Available from:


Diminsky D, Reimann ZJ, Schirmbeck R, Barenholz Y. Structural and functional characterization of liposomal recombinant hepatitis B vaccine. Journal of Liposome Research [Internet]. 1996;6(2):289–304. Available from:


Clerc S, Barenholz Y. Loading of amphipathic weak acids into liposomes in response to transmembrane calcium acetate gradients. BBA - Biomembranes [Internet]. 1995;1240(2):257–65. Available from:


Zuidam NJ, Gouw HKME, Barenholz Y, Crommelin DJA. Physical (in) stability of liposomes upon chemical hydrolysis: the role of lysophospholipids and fatty acids. BBA - Biomembranes [Internet]. 1995;1240(1):101–10. Available from:


Lasic DD, Čeh B, Stuart MCA, Guo L, Frederik PM, Barenholz Y. Transmembrane gradient driven phase transitions within vesicles: lessons for drug delivery. BBA - Biomembranes [Internet]. 1995;1239(2):145–56. Available from:


Böhm W, Schirmbeck R, Elbe A, Melber K, Diminky D, Kraal G, et al. Exogenous hepatitis B surface antigen particles processed by dendritic cells or macrophages prime murine MHC class I-restricted cytotoxic T lymphocytes in vivo. Journal of Immunology [Internet]. 1995;155(7):3313–21. Available from:


Levy MY, Polacheck I, Barenholz Y, Benita S. Efficacy Evaluation of a Novel Submicron Miconazole Emulsion in a Murine Cryptococcosis Model. Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists [Internet]. 1995;12(2):223–30. Available from:


Bergers JJ, Bloois LV, Barenholz Y, Crommelin DJA. Conformational changes of myoglobin upon interaction with negatively-charged phospholipid vesicles. Journal of Liposome Research [Internet]. 1995;5(2):311–26. Available from:


Shmeeda H, Petkova D, Barenholz Y. Cholesterol distribution in rat heart myocytes. American Journal of Physiology - Heart and Circulatory Physiology [Internet]. 1995;268(2 37-2):H759–66. Available from:


Barenholz Y, Cohen R. Rational design of amphiphile-based drug carriers and sterically stabilized carriers. Journal of Liposome Research [Internet]. 1995;5(4):905–32. Available from:


Adler A, Schachter J, Barenholz Y, Bar LK, Klein T, Korytnaya R, et al. Allogeneic human liposomal melanoma vaccine with or without IL-2 in metastatic melanoma patients: Clinical and immunobiological effects. Cancer Biotherapy [Internet]. 1995;10(4):293–306. Available from:


Haran G, Cohen R, Bar LK, Barenholz Y. Erratum: Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases (Biochim. Biophys. Acta 1151 (1993) 201-215 (BBAMEM 76069)). Biochimica et Biophysica Acta - Biomembranes [Internet]. 1994;1190(1):197. Available from:


Bolotin EM, Cohen R, Bar LK, Emanuel N, Ninio S, Barenholz Y, et al. Ammonium sulfate gradients for efficient and stable remote loading of amphipathic weak bases into liposomes and ligandoliposomes. Journal of Liposome Research [Internet]. 1994;4(1):455–79. Available from:


Caplan S, Gallily R, Barenholz Y. Characterization and purification of a mycoplasma membrane-derived macrophage-activating factor. Cancer Immunology Immunotherapy [Internet]. 1994;39(1):27–33. Available from:


Kedar E, Rutkowski Y, Braun E, Emanuel N, Barenholz Y. Delivery of Cytokines by Liposomes. I. Preparation and Characterization of Interleukin-2 Encapsulated in Long-Circulating Sterically Stabilized Liposomes. Journal of Immunotherapy [Internet]. 1994;16(1):47–59. Available from:


Shmeeda H, Petkova D, Barenholz Y. Cholesterol homeostasis in cultures of rat heart myocytes: Relationship to cellular hypertrophy. American Journal of Physiology - Heart and Circulatory Physiology [Internet]. 1994;267(5 36-5):H1689–97. Available from:


Kedar E, Braun E, Rutkowski Y, Emanuel N, Barenholz Y. Delivery of Cytokines by Liposomes. II. Interleukin-2 Encapsulated in Long-Circulating Sterically Stabilized Liposomes: Immunomodulatory and Anti-Tumor Activity in Mice. Journal of Immunotherapy [Internet]. 1994;16(2):115–24. Available from:


Gabizon A, Isacson R, Libson E, Kaufman B, Uziely B, Catane R, et al. Clinical studies of liposome-encapsulated doxorubicin. Acta Oncologica [Internet]. 1994;33(7):779–86. Available from:


Eldor A, Maclouf J, Lellouche F, Ben-Yashar V, Barenholz Y, Durst R, et al. A chronic hypercoagulable state and life-long platelet activation in beta thalassemia major. The Southeast Asian journal of tropical medicine and public health [Internet]. 1993;24 Suppl 1:92–5. Available from:


Haran G, Cohen R, Bar LK, Barenholz Y. Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases. BBA - Biomembranes [Internet]. 1993;1151(2):201–15. Available from:


Levy MY, Polacheck I, Barenholz Y, Benita S. Efficacy evaluation of a novel submicron amphotericin b emulsion in murine candidiasis. Medical Mycology [Internet]. 1993;31(3):207–18. Available from:


Gorodetsky R, Amselem S, Barenholz Y. Trace element analysis of liposomal formulations by diagnostic X-ray fluorescence spectrometry (DXS). Chemistry and Physics of Lipids [Internet]. 1993;64(1–3):31–4. Available from:


Borenstain V, Barenholz Y. Characterization of liposomes and other lipid assemblies by multiprobe fluorescence polarization. Chemistry and Physics of Lipids [Internet]. 1993;64(1–3):117–27. Available from:


Amselem S, Cohen R, Barenholz Y. In vitro tests to predict in vivo performance of liposomal dosage forms. Chemistry and Physics of Lipids [Internet]. 1993;64(1–3):219–37. Available from:


Barenholz Y. Preface. Chemistry and Physics of Lipids [Internet]. 1993;64(1–3):1–2. Available from:


Bach D, Miller IR, Barenholz Y. Thermotropic behavior of phosphatidylcholine-glucosyl ceramide mixtures: Effects of phospholipid acyl chain composition and interaction with water. Biophysical Chemistry [Internet]. 1993;47(1):77–86. Available from:


Engelhard D, Eldor A, Polacheck I, Hardan I, Ben-yehuda D, Amselem S, et al. Disseminated visceral fusariosis treated with amphotericin b-phospholipid complex. Leukemia and Lymphoma [Internet]. 1993;9(4–5):385–92. Available from:


Barenholz Y, Pal R, Wagner RR. [22] Metabolic Labeling of Viral Membrane Lipids by Fluorescent Fatty Acids: Studying Virus Fusion with Target Membranes. Methods in Enzymology [Internet]. 1993;220(C):288–312. Available from:


Barenholz Y, Amselem S, Goren D, Cohen R, Gelvan D, Samuni A, et al. Stability of liposomal doxorubicin formulations: Problems and prospects. Medicinal Research Reviews [Internet]. 1993;13(4):449–91. Available from:


Gabizon AA, Barenholz Y, Bialer M. Prolongation of the Circulation Time of Doxorubicin Encapsulated in Liposomes Containing a Polyethylene Glycol-Derivatized Phospholipid: Pharmacokinetic Studies in Rodents and Dogs. Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists [Internet]. 1993;10(5):703–8. Available from:


Yashar VB, Barenholz Y, Hy‐Am E, Rachmilewitz EA, Eldor A. Phosphatidylserine in the outer leaflet of red blood cells from β‐thalassemia patients may explain the chronic hypercoagulable state and thrombotic episodes. American Journal of Hematology [Internet]. 1993;44(1):63–5. Available from:


Gregoriadis G, Wang Z, Barenholz Y, Francis MJ. Liposome-entrapped T-cell peptide provides help for a co-entrapped B-cell peptide to overcome genetic restriction in mice and induce immunological memory. Immunology [Internet]. 1993;80(4):535–40. Available from:


Lasic DD, Frederik PM, Stuart MCA, Barenholz Y, McIntosh TJ. Gelation of liposome interior A novel method for drug encapsulation. FEBS Letters [Internet]. 1992;312(2–3):255–8. Available from:


Horowitz AT, Barenholz Y, Gabizon AA. In vitro cytotoxicity of liposome-encapsulated doxorubicin: dependence on liposome composition and drug release. BBA - Biomembranes [Internet]. 1992;1109(2):203–9. Available from:


Kalmanzon E, Zlotkin E, Cohen R, Barenholz Y. Liposomes as a model for the study of the mechanism of fish toxicity of sodium dodecyl sulfate in sea water. BBA - Biomembranes [Internet]. 1992;1103(1):148–56. Available from:


Goetschel R, Barenholz Y, Bar R. Microbial conversions in a liposomal medium. Part 2: Cholesterol oxidation by Rhodococcus erythropolis. Enzyme and Microbial Technology [Internet]. 1992;14(5):390–5. Available from:


Amselem S, Cohen R, Druckmann S, Gabizon A, Goren D, Abra RM, et al. Preparation and characterization of liposomal doxorubicin for human use. Journal of Liposome Research [Internet]. 1992;2(1):93–123. Available from:


Gabizon A, Chisin R, Amselem S, Druckmann S, Cohen R, Goren D, et al. Pharmacokinetic and imaging studies in patients receiving a formulation of liposome-associated adriamycin. British Journal of Cancer [Internet]. 1991;64(6):1125–32. Available from:


Ben-Yashar V, Barenholz Y. Characterization of the core and surface of human plasma lipoproteins. A study based on the use of five fluorophores. Chemistry and Physics of Lipids [Internet]. 1991;60(1):1–14. Available from:


Barenholz Y, Cohen T, Korenstein R, Ottolenghi M. Organization and dynamics of pyrene and pyrene lipids in intact lipid bilayers. Photo-induced charge transfer processes. Biophysical Journal [Internet]. 1991;60(1):110–24. Available from:


Goren D, Gabizon A, Barenholz Y. The influence of physical characteristics of liposomes containing doxorubicin on their pharmacological behavior. BBA - Biomembranes [Internet]. 1990;1029(2):285–94. Available from:


Almog S, Litman BJ, Wimley W, Cohen J, Wachtel EJ, Barenholz Y, et al. States of Aggregation and Phase Transformations in Mixtures of Phosphatidylcholine and Octyl Glucoside. Biochemistry [Internet]. 1990;29(19):4582–92. Available from:


Gabizon A, Amselem S, Goren D, Cohen R, Druckmann S, Fromer I, et al. Preclinical and clinical experience with a doxorubicin-liposome preparation. Journal of Liposome Research [Internet]. 1990;1(4):491–502. Available from:


Amselem S, Gabizon A, Barenholz Y. Optimization and upscaling of doxorubicin‐containing liposomes for clinical use. Journal of Pharmaceutical Sciences [Internet]. 1990;79(12):1045–52. Available from:


Ben-Yashar V, Barenholz Y. The interaction of cholesterol and cholest-4-en-3-one with dipalmitoylphosphatidylcholine. Comparison based on the use of three fluorophores. BBA - Biomembranes [Internet]. 1989;985(3):271–8. Available from:


Barenholz Y, Bach D, Thompson TE, Freire E, Correa-Freire M, Miller LR. The metastability of glucosyl ceramide in aqueous phase: effect of hydration and phosphatidylcholines of various chain length. Thermochimica Acta [Internet]. 1989;148(C):355–63. Available from:


Bar LK, Chong PLG, Barenholz Y, Thompson TE. Spontaneous transfer between phospholipid bilayers of dehydroergosterol, a fluorescent cholesterol analog. BBA - Biomembranes [Internet]. 1989;983(1):109–12. Available from:


Druckmann S, Gabizon A, Barenholz Y. Separation of liposome-associated doxorubicin from non-liposome-associated doxorubicin in human plasma: Implications for pharmacokinetic studies. BBA - Biomembranes [Internet]. 1989;980(3):381–4. Available from:


Gabizon A, Peretz T, Sulkes A, Amselem S, Ben-Yosef R, Ben-Baruch N, et al. Systemic administration of doxorubicin-containing liposomes in cancer patients: a phase I study. European Journal of Cancer and Clinical Oncology [Internet]. 1989;25(12):1795–803. Available from:


Amselem S, Gabizon A, Barenholz Y. Evaluation of a new extrusion device for the production of stable oligolamellar liposomes in a liter scale. Journal of Liposome Research [Internet]. 1989;1(3):287–301. Available from:


Gabizon A, Goren D, Barenholz Y. Investigations on the antitumor efficacy of liposome-associated doxorubicin in murine tumor models. Israel Journal of Medical Sciences [Internet]. 1988;24(9–10):512–7. Available from:


Schroeder F, Nemecz G, Barenholz Y, Gratton E, Thompson TE. Cholestatrienol time resolved fluorescence in phosphatidylcholine bilayers. In: Proceedings of SPIE - The International Society for Optical Engineering [Internet]. 1988. p. 457–65. Available from:


Pal R, Barenholz Y, Wagner RR. Pyrene Phospholipid as a Biological Fluorescent Probe for Studying Fusion of Virus Membrane with Liposomes. Biochemistry [Internet]. 1988;27(1):30–6. Available from:


Schroeder F, Nemecz G, Gratton E, Barenholz Y, Thompson TE. Fluorescence properties of cholestatrienol in phosphatidylcholine bilayer vesicles. Biophysical Chemistry [Internet]. 1988;32(1):57–72. Available from:


Yashar VB, Menashe M, Biltonen RL, Johnson ML, Barenholz Y. Interaction of trans-parinaric acid with phosphatidylcholine bilayers: comparison with the effect of other fluorophores. BBA - Biomembranes [Internet]. 1987;904(1):117–24. Available from:


Pal R, Barenholz Y, Wagner RR. Vesicular stomatitis virus membrane proteins and their interactions with lipid bilayers. BBA - Reviews on Biomembranes [Internet]. 1987;906(2):175–93. Available from:


Bar LK, Barenholz Y, Thompson TE. Dependence on Phospholipid Composition of the Fraction of Cholesterol Undergoing Spontaneous Exchange between Small Unilamellar Vesicles. Biochemistry [Internet]. 1987;26(17):5460–5. Available from:


Hresko RC, Sugár IP, Barenholz Y, Thompson TE. The lateral distribution of pyrene-labeled sphingomyelin and glucosylceramide in phosphatidylcholine bilayers. Biophysical Journal [Internet]. 1987;51(5):725–33. Available from:


Schroeder F, Barenholz Y, Gratton E, Thompson TE. A Fluorescence Study of Dehydroergosterol in Phosphatidylcholine Bilayer Vesicles. Biochemistry [Internet]. 1987;26(9):2441–8. Available from:


Amselem S, Barenholz Y, Loyter A, Nir S, Lichtenberg D. Fusion of Sendai virus with negatively charged liposomes as studied by pyrene-labelled phospholipid liposomes. BBA - Biomembranes [Internet]. 1986;860(2):301–13. Available from:


Yechiel E, Henis YI, Barenholz Y. Aging of rat heart fibroblasts: relationship between lipid composition, membrane organization and biological properties. BBA - Biomembranes [Internet]. 1986;859(1):95–104. Available from:


Yechiel E, Barenholz Y. Cultured heart cell reaggregates: a model for studying relationships between aging and lipid composition. BBA - Biomembranes [Internet]. 1986;859(1):105–9. Available from:


Samuni A, Chong PLG, Barenholz Y, Thompson TE. Physical and Chemical Modifications of Adriamycin:Lron Complex by Phospholipid Bilayers. Cancer Research [Internet]. 1986;46(2):594–9. Available from:


Bar LK, Barenholz Y, Thompson TE. Fraction of Cholesterol Undergoing Spontaneous Exchange between Small Unilamellar Phosphatidylcholine Vesicles. Biochemistry [Internet]. 1986;25(21):6701–5. Available from:


Moscona-Amir E, Henis YI, Sokolovsky M, Yechiel E, Barenholz Y. Role of Lipids in Age-Related Changes in the Properties of Muscarinic Receptors in Cultured Rat Heart Myocytes. Biochemistry [Internet]. 1986;25(24):8118–24. Available from:


Hresko RC, Sugár IP, Barenholz Y, Thompson TE. Lateral Distribution of a Pyrene-Labeled Phosphatidylcholine in Phosphatidylcholine Bilayers: Fluorescence Phase and Modulation Study. Biochemistry [Internet]. 1986;25(13):3813–23. Available from:


Chejanovsky N, Zakai N, Loyter A, Amselem S, Barenholz Y. Membrane Vesicles Containing the Sendai Virus Binding Glycoprotein, but Not the Viral Fusion Protein, Fuse with Phosphatidylserine Liposomes at Low pH. Biochemistry [Internet]. 1986;25(17):4810–7. Available from:


Gabizon A, Meshorer A, Barenholz Y. Comparative long-term study of the toxicities of free and liposome-associated doxorubicin in mice after intravenous administration. Journal of the National Cancer Institute [Internet]. 1986;77(2):459–69. Available from:


Wiener JR, Pal R, Barenholz Y, Wagner RR. Effect of the Vesicular Stomatitis Virus Matrix Protein on the Lateral Organization of Lipid Bilayers Containing Phosphatidylglycerol: Use of Fluorescent Phospholipid Analogues†. Biochemistry [Internet]. 1985;24(26):7651–8. Available from:


Yechiel E, Barenholz Y, Henis YI. Lateral mobility and organization of phospholipids and proteins in rat myocyte membranes. Journal of Biological Chemistry [Internet]. 1985;260(16):9132–6. Available from:


Yechiel E, Barenholz Y. Relationships between membrane lipid composition and biological properties of rat myocytes. Journal of Biological Chemistry [Internet]. 1985;260(16):9123–31. Available from:


Amselem S, Loyter A, Lichtenberg D, Barenholz Y. The interaction of Sendai virus with negatively charged liposomes: virus-induced lysis of carboxyfluorescein-loaded small unilamellar vesicles. BBA - Biomembranes [Internet]. 1985;820(1):1–10. Available from:


Levin IW, Thompson TE, Barenholz Y, Huang C. Two Types of Hydrocarbon Chain Interdigitation in Sphingomyelin Bilayers. Biochemistry [Internet]. 1985;24(22):6282–6. Available from:


Brown RE, Stephenson FA, Markello T, Barenholz Y, Thompson TE. Properties of a specific glycolipid transfer protein from bovine brain. Chemistry and Physics of Lipids [Internet]. 1985;38(1–2):79–93. Available from:


Reizer J, Grossowicz N, Barenholz Y. The effect of growth temperature on the thermotropic behavior of the membranes of a thermophilic Bacillus. Composition-structure-function relationships. BBA - Biomembranes [Internet]. 1985;815(2):268–80. Available from:


Gabizon A, Meshorer A, Barenholz Y. A comparative study of toxicities of free and liposome-associated adriamycin (ADM). Proceedings of the American Association for Cancer Research [Internet]. 1985;VOL. 26:No. 1468. Available from:


Pal R, Petri Jr WA, Ben-Yashar V, Barenholz Y, Wagner RR. Characterization of the Fluorophore 4-Heptadecyl-7-hydroxycoumarin: A Probe for the Head-Group Region of Lipid Bilayers and Biological Membranes. Biochemistry [Internet]. 1985;24(3):573–81. Available from:


Hresko RC, Markello TC, Barenholz Y, Thompson TE. Purification and spectroscopic properties of pyrene fatty acids. Chemistry and Physics of Lipids [Internet]. 1985;38(3):263–73. Available from:


Gabizon A, Goren D, Fuks Z, Meshorer A, Barenholz Y. Superior therapeutic activity of liposome-associated adriamycin in a murine metastatic tumour model. British Journal of Cancer [Internet]. 1985;51(5):681–9. Available from:


Cohen R, Barenholz Y. Characterization of the association of Electrophorus electricus acetylcholinesterase with sphingomyelin liposomes. Relevance to collagen-sphingomyelin interactions. BBA - Biomembranes [Internet]. 1984;778(1):94–104. Available from:


Wong M, Brown RE, Thompson TE, Barenholz Y. Glycolipid Transfer Protein from Bovine Brain. Biochemistry [Internet]. 1984;23(26):6498–505. Available from:


Cohen R, Barenholz Y, Gatt S, Dagan A. Preparation and characterization of well defined d-erythro sphingomyelins. Chemistry and Physics of Lipids [Internet]. 1984;35(4):371–84. Available from:


Wong M, Brown R, Barenholz Y, Thompson TE. Glycolipid transfer protein from bovine brain. Federation Proceedings [Internet]. 1984;43(6):no. 864. Available from:


Gabizon A, Goren D, Fuks Z, Barenholz Y, Dagan A, Meshorer A. Enhancement of Adriamycin Delivery to Liver Metastatic Cells with Increased Tumoricidal Effect Using Liposomes as Drug Carriers. Cancer Research [Internet]. 1983;43(10):4730–5. Available from:


Pal R, Petri Jr. WA, Barenholz Y, Wagner RR. Lipid and protein contributions to the membrane surface potential of vesicular stomatitis virus probed by a fluorescent pH indicator, 4-heptadecyl-7-hydroxycoumarin. BBA - Biomembranes [Internet]. 1983;729(2):185–92. Available from:


Frank A, Lichtenberg D, Thompson TE, Barenholz Y. Spontaneous Transfer of Sphingomyelin between Phospholipid Bilayers. Biochemistry [Internet]. 1983;22(24):5647–51. Available from:


Felgner PL, Thompson TE, Barenholz Y, Lichtenberg D. Kinetics of Transfer of Gangliosides from Their Micelles to Dipalmitoylphosphatidylcholine Vesicles. Biochemistry [Internet]. 1983;22(7):1670–4. Available from:


Pal R, Wiener JR, Barenholz Y, Wagner RR. Influence of the Membrane Glycoprotein and Cholesterol of Vesicular Stomatitis Virus on the Dynamics of Viral and Model Membranes: Fluorescence Studies. Biochemistry [Internet]. 1983;22(15):3624–30. Available from:


Bkaily G, Sperelakis N, Elishalom Y, Barenholz Y. Effect of Na+- or Ca2+-filled liposomes on electrical activity of cultured heart cells. American Journal of Physiology - Heart and Circulatory Physiology [Internet]. 1983;14(5):H756–61. Available from:


Michaelson DM, Barkai G, Barenholz Y. Asymmetry of lipid organization in cholinergic synaptic vesicle membranes. The Biochemical journal [Internet]. 1983;211(1):155–62. Available from:


Wiener JR, Pal R, Barenholz Y, Wagner RR. Influence of the Peripheral Matrix Protein of Vesicular Stomatitis Virus on the Membrane Dynamics of Mixed Phospholipid Vesicles: Fluorescence Studies. Biochemistry [Internet]. 1983;22(9):2162–70. Available from:


Barenholz Y, Thompson TE, Freire E, Correa-Freire MC, Bach D, Miller IR. Thermotropic Behavior of Aqueous Dispersions of Glucosylceramide-Dipalmitoylphosphatidylcholine Mixtures. Biochemistry [Internet]. 1983;22(14):3497–501. Available from:


Correa-Freire MC, Barenholz Y, Thompson TE. Glucocerebroside Transfer between Phosphatidylcholine Bilayers. Biochemistry [Internet]. 1982;21(6):1244–8. Available from:


Neumann S, Korenstein R, Barenholz Y, Ottolenghi M. Photoinduced Charge Separation and Recombination in Exciplex Systems in Lipid Bilayer Vesicles. Israel Journal of Chemistry [Internet]. 1982;22(2):125–32. Available from:


Barenholz Y, Gatt S. Sphingomyelin: Metabolism, chemical synthesis, chemical and physical properties. New Comprehensive Biochemistry [Internet]. 1982;4(C):129–77. Available from:


Goll J, Carlson FD, Barenholz Y, Litman BJ, Thompson TE. Photon correlation spectroscopic study of the size distribution of phospholipid vesicles. Biophysical Journal [Internet]. 1982;38(1):7–13. Available from:


Yedgar S, Cohen R, Gatt S, Barenholz Y. Hydrolysis of monomolecular layers of synthetic sphingomyelins by sphingomyelinase of staphylococcus aureus. Biochemical Journal [Internet]. 1982;201(3):597–603. Available from:


Litman BJ, Barenholz Y. Fluorescent Probe: Diphenylhexatriene. Methods in Enzymology [Internet]. 1982;81(C):678–85. Available from:


Dagan A, Barenholz Y, Gatt S. Synthesis of fluorescent derivatives of lipids and their potential pharmacological application. Israel Journal of Medical Sciences [Internet]. 1982;18(4):558. Available from:


Pal R, Barenholz Y, Wagner RR. Pardaxin, a hydrophobic toxin of the red sea flatfish, disassembles the intact membrane of vesicular stomatitis virus. Journal of Biological Chemistry [Internet]. 1981;256(20):10209–12. Available from:


Barenholz Y, Yechiel E, Cohen R, Deckelbaum RJ. Importance of cholesterol-phospholipid interaction in determining dynamics of normal and abetalipoproteinemia red blood cell membrane. Cell Biophysics [Internet]. 1981;3(2):115–26. Available from:


Lentz BR, Hoechli M, Barenholz Y. Acyl Chain Order and Lateral Domain Formation in Mixed Phosphatidylcholine-Sphingomyelin Multilamellar and Unilamellar Vesicles. Biochemistry [Internet]. 1981;20(24):6803–9. Available from:


Feigner PL, Freire E, Barenholz Y, Thompson TE. Asymmetric Incorporation of Trisialoganglioside into Dipalmitoylphosphatidylcholine Vesicles. Biochemistry [Internet]. 1981;20(8):2168–72. Available from:


Freire E, Schmidt CF, Feigner PL, Thompson TE, Lichtenberg D, Barenholz Y. Effect of Surface Curvature on Stability, Thermodynamic Behavior, and Osmotic Activity of Dipalmitoylphosphatidylcholine Single Lamellar Vesicles. Biochemistry [Internet]. 1981;20(12):3462–7. Available from:


Estep TN, Freire E, Anthony F, Barenholz Y, Biltonen RL, Thompson TE. Thermal Behavior of Stearoylsphingomyelin-Cholesterol Dispersions. Biochemistry [Internet]. 1981;20(25):7115–8. Available from:


Gatt S, Barenholz Y, Goldberg R, Dinur T, Besley G, Gershon ZLB, et al. Assay of Enzymes of Lipid Metabolism with Colored and Fluorescent Derivatives of Natural Lipids. Methods in Enzymology [Internet]. 1981;72(C):351–75. Available from:


Petri WA, Pal R, Wagner RR, Barenholz Y. Fluorescence Studies of Dipalmitoylphosphatidylcholine Vesicles Reconstituted with the Glycoprotein of Vesicular Stomatitis Virus. Biochemistry [Internet]. 1981;20(10):2796–800. Available from:


Petri Jr. W, Pal R, Barenholz Y, Wagner RR. Fluorescence anisotropy of a fatty acid covalently linked in vivo to the glycoprotein of vesicular stomatitis virus. Journal of Biological Chemistry [Internet]. 1981;256(6):2625–7. Available from:


Pal R, Barenholz Y, Wagner RR. Transcription of vesicular stomatitis virus activated by Pardaxin, a fish toxin that permeabilizes the virion membrane. Journal of Virology [Internet]. 1981;39(2):641–5. Available from:


Pal R, Barenholz Y, Wagner RR. Depletion and Exchange of Cholesterol from the Membrane of Vesicular Stomatitis Virus by Interaction with Serum Lipoproteins or Poly(vinylpyrrolidone) Complexed with Bovine Serum Albumin. Biochemistry [Internet]. 1981;20(3):530–9. Available from:


Gatt S, Gazit B, Barenholz Y. Effect of bile salts on the hydrolysis of gangliosides, glycoproteins and neuraminyl-lactose by the neuraminidase of Clostridium perfringens. Biochemical Journal [Internet]. 1981;193(1):267–73. Available from:


Freire E, Bach D, Correa-Freire M, Miller I, Barenholz Y. Calorimetric Investigation of the Complex Phase Behavior of Glucocerebroside Dispersions. Biochemistry [Internet]. 1980;19(16):3662–5. Available from:


Pal R, Barenholz Y, Wagner RR. Effect of cholesterol concentration on organization of viral and vesicle membranes. Probed by accessibility to cholesterol oxidase. Journal of Biological Chemistry [Internet]. 1980;255(12):5802–6. Available from:


Cestaro B, Barenholz Y, Gatt S. Hydrolysis of Di-and Trisialo Gangliosides in Micellar and Liposomal Dispersion by Bacterial Neuraminidases. Biochemistry [Internet]. 1980;19(4):615–9. Available from:


Barenholz Y, Thompson TE. Sphingomyelins in bilayers and biological membranes. Biochimica et Biophysica Acta - Biomembranes [Internet]. 1980;604(2):129–58. Available from:


Estep TN, Thompson TE, Biltonen RL, Calhoun WI, Shipley GG, Barenholz Y. Evidence for metastability in stearoylphingomyelin bilayers. Biochemistry [Internet]. 1980;19(1):20–4. Available from:


Gatt S, Gazit B, Cestaro B, Barenholz Y. Hydrolysis of gangliosides in micellar and liposomal dispersion by bacterial neuraminidases. Advances in experimental medicine and biology [Internet]. 1980;125:137–46. Available from:


Gatt S, Dinur T, Barenholz Y. A fluorometric determination of sphingomyelinase by use of fluorescent derivatives of sphingomyelin, and its application to diagnosis of Niemann-Pick disease. Clinical Chemistry [Internet]. 1980;26(1):93–6. Available from:


Barenholz Y, Ceastaro B, Lichtenberg D, Freire E, Thompson TE, Gatt S. Characterization of micellar and liposomal dispersions of gangliosides and phospholipids. Advances in experimental medicine and biology [Internet]. 1980;125:105–23. Available from:


Deckelbaum RJ, Eisenberg S, Fainaru M, Barenholz Y, Olivecrona T. In vitro production of human plasma low density lipoprotein-like particles. A model for very low density lipoprotein catabolism. Journal of Biological Chemistry [Internet]. 1979;254(13):6079–87. Available from:


Borochov H, Shinitzky M, Barenholz Y. Sphingomyelin phase transition in the sheep erythrocyte membrane. Cell Biochemistry and Biophysics [Internet]. 1979;1(3):219–28. Available from:


Estep TN, Mountcastle DB, Barenholz Y, Biltonen RL, Thompson TE. Thermal Behavior of Synthetic Sphingomyelin-Cholesterol Dispersions. Biochemistry [Internet]. 1979;18(10):2112–7. Available from:


Correa-Freire MC, Freire E, Barenholz Y, Biltonen RL, Thompson TE. Thermotropic Behavior of Monoglucocerebroside-Dipalmitoylphosphatidylcholine Multilamellar Liposomes. Biochemistry [Internet]. 1979;18(3):442–5. Available from:


Kapitulnik J, Tshershedsky M, Barenholz Y. Fluidity of the rat liver microsomal membrane: Increase at birth. Science [Internet]. 1979;206(4420):843–4. Available from:


Shinitzky M, Barenholz Y. Fluidity parameters of lipid regions determined by fluorescence polarization. BBA - Reviews on Biomembranes [Internet]. 1978;515(4):367–94. Available from:


Patzer EJ, Moore NF, Barenholz Y, Shaw JM, Wagner RR. Lipid organization of the membrane of vesicular stomatitis virus. Journal of Biological Chemistry [Internet]. 1978;253(13):4544–50. Available from:


Schmidt CF, Barenholz Y, Huang C, Thompson TE. Monolayer coupling in sphingomyelin bilayer systems. Nature [Internet]. 1978;271(5647):775–7. Available from:


Patzer EJ, Wagner RR, Barenholz Y. Cholesterol oxidase as a probe for studying membrane organisation [32]. Nature [Internet]. 1978;274(5669):394–5. Available from:


Goldberg R, Barenholz Y, Gatt S. Synthesis of trinitrophenylaminolauric acid and the use of its glyceryl esters for assaying lipase by a spectrophotometric procedure. Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism [Internet]. 1978;531(2):237–41. Available from:


Barenholz Y, Erulkar SD, Meiri H, Rahamimoff R. Increase in quantal transmitter release by calcium- and sodium-containing phosphatidylcholine liposomes [proceedings]. Journal of Physiology [Internet]. 1978;284:65P-66P. Available from:


Gatt S, Dinur T, Barenholz Y. A spectrophotometric method for determination of sphingomyelinase. Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism [Internet]. 1978;530(3):503–7. Available from:


Cohen R, Barenholz Y. Correlation between the thermotropic behavior of sphingomyelin liposomes and sphingomyelin hydrolysis by sphingomyelinase of Staphylococcus aureus. BBA - Biomembranes [Internet]. 1978;509(1):181–7. Available from:


Rahamimoff R, Meiri H, Erulkar SD, Barenholz Y. Changes in transmitter release induced by ion-containing liposomes. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 1978;75(10):5214–6. Available from:


Barenholz Y, Gafni A, Eisenberg S. Apparent microviscosity of intact and post-lipolysis (“remnant”) very low density lipoprotein particles. Chemistry and Physics of Lipids [Internet]. 1978;21(3):179–85. Available from:


Cestaro B, Barenholz Y, Gatt S. Hydrolysis by bacterial neuraminidases of gangliosides in form of micelle or liposome. Italian Journal of Biochemistry [Internet]. 1978;27(1):64–5. Available from:


Barenholz Y, Patzer EJ, Moore NF, Wagner RR. Cholesterol oxidase as a probe for studying membrane composition and organization. Advances in experimental medicine and biology [Internet]. 1978;101:45–56. Available from:


Moore NF, Patzer EJ, Wagner RR, Barenholz Y. Effect of Phospholipase C and Cholesterol Oxidase on Membrane Integrity, Microviscosity, and Infectivity of Vesicular Stomatitis Virus. Biochemistry [Internet]. 1977;16(21):4708–15. Available from:


Schmidt CF, Barenholz Y, Huang C, Thompson TE. Phosphatidylcholine 13C-Labeled Carbonyls as a Probe of Bilayer Structure. Biochemistry [Internet]. 1977;16(18):3948–54. Available from:


Barenholz Y, Gibbes D, Litman BJ, Goll J, Thompson TE, Carlson FD. A Simple Method for the Preparation of Homogeneous Phospholipid Vesicles. Biochemistry [Internet]. 1977;16(12):2806–10. Available from:


Schmidt CF, Barenholz Y, Thompson TE. A Nuclear Magnetic Resonance Study of Sphingomyelin in Bilayer Systems. Biochemistry [Internet]. 1977;16(12):2649–56. Available from:


Hertz R, Barenholz Y. The relations between the composition of liposomes and their interaction with triton X-100. Journal of Colloid And Interface Science [Internet]. 1977;60(1):188–200. Available from:


Lentz BR, Barenholz Y, Thompson TE. Fluorescence Depolarization Studies of Phase Transitions and Fluidity in Phospholipid Bilayers. 1. Single Component Phosphatidylcholine Liposomes. Biochemistry [Internet]. 1976;15(20):4521–8. Available from:


Lentz BR, Barenholz Y, Thompson TE. Fluorescence Depolarization Studies of Phase Transitions and Fluidity in Phospholipid Bilayers. 2. Two-Component Phosphatidylcholine Liposomes. Biochemistry [Internet]. 1976;15(20):4529–37. Available from:


Barenholz Y, Moore NF, Wagner RR. Enveloped Viruses as Model Membrane Systems: Microviscosity of Vesicular Stomatitis Virus and Host Cell Membranes. Biochemistry [Internet]. 1976;15(16):3563–70. Available from:


Kutchai H, Barenholz Y, Ross TF, Wermer DE. Developmental changes in plasma membrane fluidity in chick embryo heart. BBA - Biomembranes [Internet]. 1976;436(1):101–12. Available from:


Stubbs GW, Litman BJ, Barenholz Y. Microviscosity of the Hydrocarbon Region of the Bovine Retinal Rod Outer Segment Disk Membrane Determined by Fluorescent Probe Measurements. Biochemistry [Internet]. 1976;15(13):2766–72. Available from:


Barenholz Y, Suurkuusk J, Mountcastle D, Thompson TE, Biltonen RL. A Calorimetric Study of the Thermotropic Behavior of Aqueous Dispersions of Natural and Synthetic Sphingomyelins. Biochemistry [Internet]. 1976;15(11):2441–7. Available from:


Suurkuusk J, Lentz BR, Barenholz Y, Biltonen RL, Thompson TE. A Calorimetric and Fluorescent Probe Study of the Gel-Liquid Crystalline Phase Transition in Small, Single-Lamellar Dipalmitoylphosphatidylcholine Vesicles. Biochemistry [Internet]. 1976;15(7):1393–401. Available from:


Moore NF, Barenholz Y, McAllister PE, Wagner RR. Comparative membrane microviscosity of fish and mammalian rhabdoviruses studied by fluorescence depolarization. Journal of Virology [Internet]. 1976;19(1):275–8. Available from:


Moore NF, Barenholz Y, Wagner RR. Microviscosity of togavirus membranes studied by fluorescence depolarization: influence of envelope proteins and the host cell. Journal of Virology [Internet]. 1976;19(1):126–35. Available from:


Litman BJ, Barenholz Y. The optical activity of d-erythro-sphingomyelin and its contribution to the circular dichroism of sphingomyelin-containing systems. BBA - Biomembranes [Internet]. 1975;394(2):166–72. Available from:


Quinn PJ, Barenholz Y. A comparison of the activity of phosphatidylinositol phosphodiesterase against substrate in dispersions and as monolayers at the air water interface. Biochemical Journal [Internet]. 1975;149(1):199–208. Available from:


Hertz R, Barenholz Y. Permeability and integrity properties of lecithin-sphingomyelin liposomes. Chemistry and Physics of Lipids [Internet]. 1975;15(2):138–56. Available from:


Lentz BR, Barenholz Y, Thompson TE. A simple method for the synthesis of cholesterol esters in high yield. Chemistry and Physics of Lipids [Internet]. 1975;15(2):216–21. Available from:


Barenholz Y, Gatt S. [49] Separation of Sphingosine Bases by Chromatography on Columns of Silica Gel. Methods in Enzymology [Internet]. 1975;35(C):529–33. Available from:


Barenholz Y, Gatt S. [29] Acetyl coenzyme A: Long-chain base acetyltransferase from the microsomes of Hansenula ciferri. Methods in Enzymology [Internet]. 1975;35(C):242–7. Available from:


Barenholz Y, Gatt S. [30] Acetyl coenzyme A: Amine acetyltransferase from the soluble fraction of Hansenula ciferri. Methods in Enzymology [Internet]. 1975;35(C):247–53. Available from:


Shinitzky M, Barenholz Y. Dynamics of the hydrocarbon layer in liposomes of lecithin and sphingomyelin containing dicetylphosphate. Journal of Biological Chemistry [Internet]. 1974;249(8):2652–7. Available from:


Barenholz Y, Edelman I, Shimon G. Amine:acetyl coenzyme A acetyltransferase from the soluble fraction of Hansenula ciferri: Isolation and properties. BBA - Enzymology [Internet]. 1974;358(2):262–74. Available from:


Yedgar S, Barenholz Y, Cooper VG. Molecular weight, shape and structure of mixed micelles of Triton X-100 and sphingomyelin. BBA - Biomembranes [Internet]. 1974;363(1):98–111. Available from:


Cooper VG, Yedgar S, Barenholz Y. Diffusion coefficients of mixed micelles of Triton X-100 and sphingomyelin and of sonicated sphingomyelin liposomes, measured by autocorrelation spectroscopy of Rayleigh scattered light. BBA - Biomembranes [Internet]. 1974;363(1):86–97. Available from:


Barenholz Y, Leffler JN, Lefer AM. Detection by chemical methods of a myocardial depressant factor in plasma of animals in circulatory shock. Israel Journal of Medical Sciences [Internet]. 1973;9(5):640–7. Available from:


Hertz R, Barenholz Y. Glucose release measurements from liposomes with an oxygen electrode. BBA - Biomembranes [Internet]. 1973;330(1):1–7. Available from:


Barenholz Y, Gadot N, Valk E, Gatt S. Identification of the enzymatic lesions responsible for the accumulation of acetylated sphingosine bases in the yeast Hansenula ciferri. Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism [Internet]. 1973;306(2):341–5. Available from:


Gatt S, Herzl A, Barenholz Y. Hydrolysis of sphingomyelin liposomes by sphingomyelinase. FEBS Letters [Internet]. 1973;30(3):281–5. Available from:


Gatt S, Barenholz Y. Enzymes of complex lipid metabolism. Annual review of biochemistry [Internet]. 1973;42:61–90. Available from:


Litvin Y, Leffler JN, Barenholz Y, Lefer AM. Factors influencing the in vitro production of a myocardial depressant factor. Biochemical medicine [Internet]. 1973;8(2):199–212. Available from:


Leffler JN, Litvin Y, Barenholz Y, Lefer AM. Proteolysis in formation of a myocardial depressant factor during shock. The American journal of physiology [Internet]. 1973;224(4):824–31. Available from:


Barenholz Y, Gatt S. Long chain base-acetyl coenzyme A acetyltransferase from the microsomes of Hansenula ciferri. II. Kinetic properties. Journal of Biological Chemistry [Internet]. 1972;247(21):6834–9. Available from:


Barenholz Y, Gatt S. Long chain base-acetyl coenzyme A acetyltransferase from the microsomes of Hansenula ciferri. I. Isolation and properties. Journal of Biological Chemistry [Internet]. 1972;247(21):6827–33. Available from:


Lefer AM, Barenholz Y. Pancreatic hydrolases and the formation of a myocardial depressant factor in shock. The American journal of physiology [Internet]. 1972;223(5):1103–9. Available from:


Barenholz Y, Edelman I, Gatt S. The metabolic basis for the accumulation of acetylated sphingosine bases in the yeast Hansenula ciferri. Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism [Internet]. 1971;248(3):458–65. Available from:


Gatt S, Barenholz Y. [26] Sphingomyelinase from rat brain. Methods in Enzymology [Internet]. 1969;14(C):144–9. Available from:


Gatt S, Barenholz Y. [31] Phospholipase A1 from rat brain, specific for α′ position of lecithin. EC Phosphatide acyl-hydrolase. Methods in Enzymology [Internet]. 1969;14(C):167–70. Available from:


Barenholz Y, Gatt S. Acetylation of sphingosine bases and long-chain amines by cell-free preparations of Hansenula ciferri. Biochemical and Biophysical Research Communications [Internet]. 1969;35(5):676–80. Available from:


Gatt S, Barenholz Y. Degradation of sphingosine bases by cell-free preparations. α-hydroxy palmitic acid, an intermediate of phytosphingosine degradation. Biochemical and Biophysical Research Communications [Internet]. 1968;32(4):588–94. Available from:


Barenholz Y, Gatt S. Degradation of Sphingosine, Dihydrosphingosine, and Phytosphingosine in Rats. Biochemistry [Internet]. 1968;7(7):2603–9. Available from:


Barenholz Y, Gatt S. Separation of sphingosine, dihydrosphingosine and phytosphingosine by chromatography on columns of silica gel. Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism [Internet]. 1968;152(4):790–3. Available from:


Barenholz Y, Gatt S. The utilization and degradation of phytosphingosine by rat liver. Biochemical and Biophysical Research Communications [Internet]. 1967;27(3):319–24. Available from:


Gatt S, Barenholz Y, Roitman A. Isolation of rat brain lecithinase-A, specific for the α↑-position of lecithin. Biochemical and Biophysical Research Communications [Internet]. 1966;24(2):169–72. Available from: