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The Faculty of Medicine - Biochemistry and Molecular Biology: Barshavit Zvi


 Last updated September 2023 - Biochemistry and Molecular Biology 

List of Publications


Bar-Shavit Z, Goldman R. Modulation of phagocyte activity by substance P and neurotensin [Internet]. The Neuroendocrine Immune Network. 2018. Available from:


Krisher T, Bar-Shavit Z. Regulation of osteoclastogenesis by integrated signals from toll-like receptors. Journal of Cellular Biochemistry [Internet]. 2014;115(12):2146–54. Available from:


Aker M, Rouvinski A, Hashavia S, Ta-Shma A, Shaag A, Zenvirt S, et al. An SNX10 mutation causes malignant osteopetrosis of infancy. Journal of Medical Genetics [Internet]. 2012;49(4):221–6. Available from:


Bar-Shavit Z. Erratum: The osteoclast: A multinucleated, hematopoietic-origin, bone-resorbing osteoimmune cell(J Cell Biochem (2007) 102, (1130-1139)). Journal of Cellular Biochemistry [Internet]. 2008;104(5):1946–7. Available from:


Bar-Shavit Z. Taking a Toll on the bones: Regulation of bone metabolism by innate immune regulators. Autoimmunity [Internet]. 2008;41(3):195–203. Available from:


Bar-Shavit Z. The osteoclast: A multinucleated, hematopoietic-origin, bone-resorbing osteoimmune cell. Journal of Cellular Biochemistry [Internet]. 2007;102(5):1130–9. Available from:


Amcheslavsky A, Bar-Shavit Z. Toll-like receptor 9 ligand blocks osteoclast differentiation through induction of phosphatase. Journal of Bone and Mineral Research [Internet]. 2007;22(8):1301–10. Available from:


Aharon R, Bar-Shavit Z. Involvement of aquaporin 9 in osteoclast differentiation. Journal of Biological Chemistry [Internet]. 2006;281(28):19305–9. Available from:


Amcheslavsky A, Bar-Shavit Z. Interleukin (IL)-12 mediates the anti-osteoclastogenic activity of CpG-oligodeoxynucleotides. Journal of Cellular Physiology [Internet]. 2006;207(1):244–50. Available from:


Amcheslavsky A, Hemmi H, Akira S, Bar-Shavit Z. Differential contribution of osteoclast- and osteoblast-lineage cells to CpG-oligodeoxynucleotide (CpG-ODN) modulation of osteoclastogenesis. Journal of Bone and Mineral Research [Internet]. 2005;20(9):1692–9. Available from:


Saltman LH, Javed A, Ribadeneyra J, Hussain S, Young DW, Osdoby P, et al. Organization of transcriptional regulatory machinery in osteoclast nuclei: Compartmentalization of Runx1. Journal of Cellular Physiology [Internet]. 2005;204(3):871–80. Available from:


Zou W, Amcheslavsky A, Takeshita S, Drissi H, Bar-Shavit Z. TNF-α expression is transcriptionally regulated by RANK ligand. Journal of Cellular Physiology [Internet]. 2005;202(2):371–8. Available from:


Amcheslavsky A, Zou W, Bar-Shavit Z. Toll-like receptor 9 regulates tumor necrosis factor-α expression by different mechanisms: Implications for osteoclastogenesis. Journal of Biological Chemistry [Internet]. 2004;279(52):54039–45. Available from:


Zou W, Amcheslavsky A, Bar-Shavit Z. CpG oligodeoxynucleotides modulate the osteoclastogenic activity of osteoblasts via toll-like receptor 9. Journal of Biological Chemistry [Internet]. 2003;278(19):16732–40. Available from:


Hakim I, Bar-Shavit Z. Modulation of TNF-α expression in bone marrow macrophages: Involvement of vitamin D response element. Journal of Cellular Biochemistry [Internet]. 2003;88(5):986–98. Available from:


Zou WEI, Schwartz H, Endres S, Hartmann G, Bar-Shavit ZVI. CpG oligonucleotides: Novel regulators of osteoclast differentiation. FASEB Journal [Internet]. 2002;16(3):274–82. Available from:


Zou W, Bar-Shavit Z. Dual modulation of osteoclast differentiation by lipopolysaccharide. Journal of Bone and Mineral Research [Internet]. 2002;17(7):1211–8. Available from:


Zou W, Hakim I, Tschoep K, Endres S, Bar-Shavit Z. G protein β2 subunit antisense oligonucleotides inhibit cell proliferation and disorganize microtubule and mitotic spindle organization. Journal of Cellular Biochemistry [Internet]. 2001;83(1):136–46. Available from:


Zou W, Hakim I, Tschoep K, Endres S, Bar-Shavit Z. Tumor necrosis factor-α mediates RANK ligand stimulation of osteoclast differentiation by an autocrine mechanism. Journal of Cellular Biochemistry [Internet]. 2001;83(1):70–83. Available from:


Rosen H, Krichevsky A, Bar-Shavit Z. The enkephalinergic osteoblast. Journal of Bone and Mineral Research [Internet]. 1998;13(10):1515–20. Available from:


Rosen H, Krichevsky A, Polakiewicz RD, Benzakine S, Bar-Shavit Z. Developmental regulation of proenkephalin gene expression in osteoblasts. Molecular Endocrinology [Internet]. 1995;9(11):1621–31. Available from:


Abu-Amer Y, Bar-Shavit Z. Erratum: Regulation of TNF-α release from bone marrow-derived macrophages by vitamin D. (Journal of Cellular Biochemistry 55: (1994) (435-444). Journal of Cellular Biochemistry [Internet]. 1994;56(3):426. Available from:


Abu-Amer Y, Bar-Shavit Z. Modulation of vitamin D increased H2O2 production and MAC-2 expression in the bone marrow-derived macrophages by estrogen. Calcified Tissue International [Internet]. 1994;55(1):29–32. Available from:


Rosen H, Bar‐Shavit Z. Dual role of osteoblastic proenkephalin derived peptides in skeletal tissues. Journal of Cellular Biochemistry [Internet]. 1994;55(3):334–9. Available from:


Abu‐Amer Y, Bar‐Shavit Z. Regulation of TNF‐α release from bone marrow–derived macrophages by vitamin D. Journal of Cellular Biochemistry [Internet]. 1994;55(4):435–44. Available from:


Abu-Amer Y, Bar-Shavit Z. Impaired bone marrow-derived macrophage differentiation in vitamin D deficiency. Cellular Immunology [Internet]. 1993;151(2):356–68. Available from:


Rosen H, Polakiewicz RD, Benzakine S, Bar-Shavit Z. Proenkephalin A in bone-derived cells. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 1991;88(9):3705–9. Available from:


Levi-Schaffer F, Bar-Shavit Z. Osteoblast-like cell line maintains in vitro rat peritoneal mast cell viability and functional activity. Immunology [Internet]. 1990;69(1):145–9. Available from:


Schlesinger M, Bar-Shavit Z, Hadar R, Rabinowitz R. Modulation of the expression of CD4 on HL-60 cells by exposure to 1,25-dihydroxyvitamin D3. Immunology Letters [Internet]. 1989;22(4):307–11. Available from:


Gavison R, Bar-Shavit Z. Impaired macrophage activation in vitamin D3 deficiency: Differential in vitro effects of 1,25-dihydroxyvitamin D3 on mouse peritoneal macrophage functions. Journal of Immunology [Internet]. 1989;143(11):3686–90. Available from:


Hruska KA, Bar-Shavit Z, Malone JD, Teitelbaum S. Ca2+ priming during vitamin D-induced monocytic differentiation of a human leukemia cell line. Journal of Biological Chemistry [Internet]. 1988;263(31):16039–44. Available from:


Stenson WF, Teitelbaum SL, Bar‐Shavit Z. Arachidonic acid metabolism by a vitamin D3‐differentiated human leukemic cell line. Journal of Bone and Mineral Research [Internet]. 1988;3(5):561–71. Available from:


Clohisy DR, Bar-Shavit Z, Chappel JC, Teitelbaum SL. 1,25-Dihydroxyvitamin D3 modulates bone marrow macrophage precursor proliferation and differentiation: Up-regulation of the mannose receptor. Journal of Biological Chemistry [Internet]. 1987;262(33):15922–9. Available from:


Rodan SB, Imai Y, Thiede MA, Wesolowski G, Thompson D, Bar-Shavit Z, et al. Characterization of a Human Osteosarcoma Cell Line (Saos-2) with Osteoblastic Properties. Cancer Research [Internet]. 1987;47(18):4961–6. Available from:


Bar-Shavit Z, Horst RL, Chappel JC, Ross FP, Gray RW, Teitelbaum SL. 25-Hydroxyvitamin D3 metabolism in a human leukemia cell line. Calcified Tissue International [Internet]. 1986;39(5):328–33. Available from:


Bar-Shavit Z, Goldman R. Substance P and neurotensin. Methods in Enzymology [Internet]. 1986;132(C):326–34. Available from:


Welgus HG, Campbell EJ, Bar-Shavit Z. Human alveolar macrophages produce a fibroblast-like collagenase and collagenase inhibitor. Chest [Internet]. 1986;89(3 SUPPL.):128S. Available from:


Bar-Shavit Z, Kahn AJ, Stone KR, Trial J, Hilliard T, Reitsma PH, et al. Reversibility of vitamin D-induced human leukemia cell-line maturation. Endocrinology [Internet]. 1986;118(2):679–86. Available from:


Bar-Shavit Z, Teitelbaum SL, Stricklin GP, Eisen AZ, Kahn AJ, Welgus HG. Differentiation of a human leukemia cell line and expression of collagenase inhibitor. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 1985;82(16):5380–4. Available from:


Welgus HG, Campbell EJ, Bar-Shavit Z, Senior RM, Teitelbaum SL. Human alveolar macrophages produce a fibroblast-like collagenase and collagenase inhibitor. Journal of Clinical Investigation [Internet]. 1985;76(1):219–24. Available from:


Key L, Carnes D, Cole S, Holtrop M, Bar-Shavit Z, Shapiro F, et al. Treatment of Congenital Osteopetrosis with High-Dose Calcitriol. New England Journal of Medicine [Internet]. 1984;310(7):409–15. Available from:


Bar-Shavit Z, Kahn AJ, Pegg LE. Glucocorticoids modulate macrophage surface oligosaccharides and their bone binding activity. Journal of Clinical Investigation [Internet]. 1984;73(5):1277–83. Available from:


Teitelbaum SL, Bar-Shavit Z, Fallon MD, Imbimbo C, Malone JD, Kahn AJ. Glucocorticoids and bone resorption. Advances in Experimental Medicine and Biology [Internet]. 1984;171:121–9. Available from:


Reitsma PH, Rothberg PG, Astrin SM, Trial J, Bar-shavit Z, Hall A, et al. Regulation of myc gene expression in HL-60 leukaemia cells by a vitamin D metabolite. Nature [Internet]. 1983;306(5942):492–4. Available from:


Goldman R, Bar-Shavit Z, Romeo D. Neurotensin modulates human neutrophil locomotion and phagocytic capability. FEBS Letters [Internet]. 1983;159(1–2):63–7. Available from:


GOLDMAN R, BAR‐SHAVIT Z. On the Mechanism of the Augmentation of the Phagocytic Capability of Phagocytic Cells by Tuftsin, Substance P, Neurotensin, and Kentsin and the Interrelationship between Their Receptors. Annals of the New York Academy of Sciences [Internet]. 1983;419(1):143–55. Available from:


Bar-Shavit Z, Teitelbaum SL, Kahn AJ. Saccharides mediate the attachment of rat macrophages to bone in vitro. Journal of Clinical Investigation [Internet]. 1983;72(2):516–25. Available from:


Bar-Shavit Z, Kahn AJ, Teitelbaum SL. Defective binding of macrophages to bone in rodent osteomalacia and vitamin D deficiency. In vitro evidence for a cellular defect and altered saccharides in the bone matrix. Journal of Clinical Investigation [Internet]. 1983;72(2):526–34. Available from:


Goldman R, Bar-Shavit Z, Shezen E, Terry S, Blumberg S. Enhancement of phagocytosis by neurotensin, a newly found biological activity of the neuropeptide. Advances in experimental medicine and biology [Internet]. 1982;155:133–41. Available from:


Bar-Shavit Z, Terry S, Blumberg S, Goldman R. Neurotensin - macrophage interaction: Specific binding and augmentation of phagocytosis. Neuropeptides [Internet]. 1982;2(6):325–35. Available from:


Bar-Shavit Z, Goldman R. Tuftsin and substance P as modulators of phagocyte functions. Advances in experimental medicine and biology [Internet]. 1982;141:549–58. Available from:


Bar-Shavit Z, Noff D, Edelstein S, Meyer M, Shibolet S, Goldman R. 1,25-Dihydroxyvitamin D3 and the regulation of macrophage function. Calcified Tissue International [Internet]. 1981;33(1):673–6. Available from:


Bar-Shavit Z, Goldman R, Stabinsky Y. Enhancement of phagocytosis by substance P and its N-terminal tetrapeptide. Israel Journal of Medical Sciences [Internet]. 1981;17(5):392. Available from:


Bar-Shavit Z, Goldman R, Ofek I, Sharon N, Mirelman D. Mannose-binding activity of Escherichia coli: A determinant of attachment and ingestion of the bacteria by macrophages. Infection and Immunity [Internet]. 1980;29(2):417–24. Available from:


Bar-Shavit Z, Goldman R, Stabinsky Y, Gottlieb P, Fridkin M, Teichberg VI, et al. Enhancement of phagocytosis - A newly found activity of Substance P residing in its N-terminal tetrapeptide sequence. Biochemical and Biophysical Research Communications [Internet]. 1980;94(4):1445–51. Available from:


Mantovani A, Bar Shavit Z, Peri G, Polentarutti N, Bordignon C, Sessa C, et al. Natural cytotoxicity on tumour cells of human macrophages obtained from diverse anatomical sites. Clinical and Experimental Immunology [Internet]. 1980;39(3):776–84. Available from:


Bar-Shavit Z, Bursuker I, Goldman R. Functional tuftsin binding sites on macrophage-like tumor line P388DI and on bone marrow cells differentiated in vitro into mononuclear phagocytes. Molecular and Cellular Biochemistry [Internet]. 1980;30(3):151–5. Available from:


Stabinsky Y, Bar-Shavit Z, Fridkin M, Goldman R. On the mechanism of action of the phagocytosis-stimulating peptide tuftsin. Molecular and Cellular Biochemistry [Internet]. 1980;30(2):71–7. Available from:


Goldman R, Bar-Shavit Z, Raz A. Functional similarity and diversity in peritoneal macrophage populations induced in vivo by various stimuli. Advances in Experimental Medicine and Biology [Internet]. 1979;121(A):323–32. Available from:


Bar‐Shavit Z, Raz A, Goldman R. Complement and Fc receptor‐mediated phagocytosis of normal and stimulated mouse peritoneal macrophages. European Journal of Immunology [Internet]. 1979;9(5):385–91. Available from:


Bar‐Shavit Z, Stabinsky Y, Fridkin M, Goldman R. Tuftsin‐macrophage interaction: Specific binding and augmentation of phagocytosis. Journal of Cellular Physiology [Internet]. 1979;100(1):55–62. Available from:


Goldman R, Bar-Shavit Z, Bar-Shavit Z. Dual effect of normal and stimulated macrophages and their conditioned media on target cell proliferation. Journal of the National Cancer Institute [Internet]. 1979;63(4):1009–16. Available from:


Bar-Shavit Z, Ofek I, Goldman R, Mirelman D, Sharon N. Mannose residues on phagocytes as receptors for the attachment of Escherichia coli and Salmonella typhi. Biochemical and Biophysical Research Communications [Internet]. 1977;78(1):455–60. Available from:


Bar-Shavit Z, Goldman R. Concanavalin A-mediated attachment and ingestion of yeast cells by macrophages. Experimental Cell Research [Internet]. 1976;99(2):221–36. Available from: